Motif ID: DLX4_HOXD8
Z-value: 0.821


Transcription factors associated with DLX4_HOXD8:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
DLX4 | ENSG00000108813.9 | DLX4 |
HOXD8 | ENSG00000175879.7 | HOXD8 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
HOXD8 | hg19_v2_chr2_+_176994408_176994641 | 0.53 | 7.3e-03 | Click! |
DLX4 | hg19_v2_chr17_+_48046538_48046575 | -0.16 | 4.5e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 309 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 7.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.3 | 6.4 | GO:0052695 | cellular glucuronidation(GO:0052695) |
0.1 | 6.0 | GO:0016266 | O-glycan processing(GO:0016266) |
1.9 | 5.6 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
0.0 | 5.4 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
0.1 | 4.7 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
0.2 | 3.8 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
0.1 | 3.8 | GO:0070286 | axonemal dynein complex assembly(GO:0070286) |
0.0 | 3.3 | GO:0007586 | digestion(GO:0007586) |
0.1 | 2.9 | GO:0010107 | potassium ion import(GO:0010107) |
0.2 | 2.6 | GO:0046541 | saliva secretion(GO:0046541) |
0.2 | 2.5 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
0.1 | 2.5 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
0.0 | 2.5 | GO:0006749 | glutathione metabolic process(GO:0006749) |
0.1 | 2.4 | GO:0010804 | negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804) |
0.6 | 2.3 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
0.1 | 1.9 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
0.5 | 1.6 | GO:0030505 | inorganic diphosphate transport(GO:0030505) |
0.1 | 1.6 | GO:1902260 | negative regulation of delayed rectifier potassium channel activity(GO:1902260) |
0.2 | 1.4 | GO:0035609 | C-terminal protein deglutamylation(GO:0035609) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 102 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 5.8 | GO:0005796 | Golgi lumen(GO:0005796) |
0.1 | 2.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
0.0 | 2.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
0.0 | 2.5 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
0.0 | 1.7 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
0.0 | 1.3 | GO:0034451 | centriolar satellite(GO:0034451) |
0.4 | 1.1 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
0.2 | 1.1 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.1 | 1.1 | GO:0070652 | HAUS complex(GO:0070652) |
0.0 | 1.1 | GO:0043194 | axon initial segment(GO:0043194) |
0.0 | 1.1 | GO:0042101 | T cell receptor complex(GO:0042101) |
0.1 | 1.0 | GO:0002177 | manchette(GO:0002177) |
0.1 | 1.0 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
0.0 | 1.0 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
0.0 | 0.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.1 | 0.8 | GO:0036157 | outer dynein arm(GO:0036157) |
0.0 | 0.8 | GO:0072559 | NLRP3 inflammasome complex(GO:0072559) |
0.0 | 0.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
0.0 | 0.8 | GO:0032982 | myosin filament(GO:0032982) |
0.0 | 0.8 | GO:0030286 | dynein complex(GO:0030286) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 188 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 8.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
0.2 | 5.2 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
1.3 | 5.0 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
0.7 | 5.0 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
0.1 | 4.5 | GO:0004364 | glutathione transferase activity(GO:0004364) |
0.2 | 4.0 | GO:0002162 | dystroglycan binding(GO:0002162) |
0.0 | 2.9 | GO:0005178 | integrin binding(GO:0005178) |
0.2 | 2.8 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.9 | 2.7 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
0.6 | 2.4 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
0.1 | 2.4 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
0.2 | 2.1 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
0.3 | 2.0 | GO:0047756 | chondroitin 4-sulfotransferase activity(GO:0047756) |
0.1 | 2.0 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
0.0 | 1.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
0.4 | 1.8 | GO:0035529 | NADH pyrophosphatase activity(GO:0035529) |
0.1 | 1.8 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
0.1 | 1.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
0.0 | 1.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.4 | 1.4 | GO:1904493 | Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 20 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 9.0 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 3.0 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
0.0 | 1.5 | PID_ECADHERIN_NASCENT_AJ_PATHWAY | E-cadherin signaling in the nascent adherens junction |
0.0 | 1.0 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
0.0 | 0.9 | PID_FRA_PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
0.0 | 0.9 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
0.0 | 0.8 | PID_P38_ALPHA_BETA_PATHWAY | Regulation of p38-alpha and p38-beta |
0.0 | 0.8 | PID_BMP_PATHWAY | BMP receptor signaling |
0.0 | 0.8 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
0.0 | 0.7 | PID_INSULIN_PATHWAY | Insulin Pathway |
0.0 | 0.6 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
0.0 | 0.6 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
0.0 | 0.5 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.0 | 0.4 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
0.0 | 0.4 | PID_WNT_SIGNALING_PATHWAY | Wnt signaling network |
0.0 | 0.3 | PID_DNA_PK_PATHWAY | DNA-PK pathway in nonhomologous end joining |
0.0 | 0.2 | PID_IL5_PATHWAY | IL5-mediated signaling events |
0.0 | 0.2 | PID_ERB_GENOMIC_PATHWAY | Validated nuclear estrogen receptor beta network |
0.0 | 0.1 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.0 | 0.1 | PID_IL27_PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 41 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 9.3 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
0.1 | 6.2 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.2 | 6.0 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.4 | 5.5 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.2 | 4.9 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
0.3 | 4.4 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
0.1 | 3.2 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
0.1 | 2.7 | REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
0.0 | 1.5 | REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX | Genes involved in Degradation of the extracellular matrix |
0.1 | 1.4 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.0 | 1.4 | REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
0.1 | 1.0 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
0.0 | 1.0 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
0.1 | 0.9 | REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
0.0 | 0.9 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
0.0 | 0.9 | REACTOME_DOWNSTREAM_TCR_SIGNALING | Genes involved in Downstream TCR signaling |
0.0 | 0.9 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 0.9 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
0.0 | 0.8 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
0.1 | 0.7 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |