Motif ID: DLX4_HOXD8

Z-value: 0.821

Transcription factors associated with DLX4_HOXD8:

Gene SymbolEntrez IDGene Name
DLX4 ENSG00000108813.9 DLX4
HOXD8 ENSG00000175879.7 HOXD8

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXD8hg19_v2_chr2_+_176994408_1769946410.537.3e-03Click!
DLX4hg19_v2_chr17_+_48046538_48046575-0.164.5e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of DLX4_HOXD8

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_16921601 3.782 ENST00000402239.3
ENST00000310398.2
ENST00000414935.1
AGR3


anterior gradient 3


chr4_-_70518941 2.866 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr4_-_100356291 2.841 ENST00000476959.1
ENST00000482593.1
ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr4_-_100356551 2.804 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr6_-_52705641 2.784 ENST00000370989.2
GSTA5
glutathione S-transferase alpha 5
chr2_+_228736321 2.663 ENST00000309931.2
DAW1
dynein assembly factor with WDR repeat domains 1
chr4_+_70861647 2.568 ENST00000246895.4
ENST00000381060.2
STATH

statherin

chr21_-_43735628 2.494 ENST00000291525.10
ENST00000518498.1
TFF3

trefoil factor 3 (intestinal)

chr11_+_27076764 2.381 ENST00000525090.1
BBOX1
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr12_-_71551652 2.278 ENST00000546561.1
TSPAN8
tetraspanin 8
chr12_+_20963647 2.220 ENST00000381545.3
SLCO1B3
solute carrier organic anion transporter family, member 1B3
chr12_+_20963632 2.193 ENST00000540853.1
ENST00000261196.2
SLCO1B3

solute carrier organic anion transporter family, member 1B3

chr18_-_24722995 1.975 ENST00000581714.1
CHST9
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9
chr4_+_69681710 1.799 ENST00000265403.7
ENST00000458688.2
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr17_+_68071389 1.744 ENST00000283936.1
ENST00000392671.1
KCNJ16

potassium inwardly-rectifying channel, subfamily J, member 16

chr2_+_228736335 1.733 ENST00000440997.1
ENST00000545118.1
DAW1

dynein assembly factor with WDR repeat domains 1

chrX_+_119029800 1.707 ENST00000371431.3
ENST00000371423.2
ENST00000371425.4
ENST00000394594.2
AKAP14



A kinase (PRKA) anchor protein 14



chr5_+_140220769 1.670 ENST00000531613.1
ENST00000378123.3
PCDHA8

protocadherin alpha 8

chr6_+_131958436 1.614 ENST00000357639.3
ENST00000543135.1
ENST00000427148.2
ENST00000358229.5
ENPP3



ectonucleotide pyrophosphatase/phosphodiesterase 3



chr16_-_28621353 1.600 ENST00000567512.1
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 309 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 6.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 6.0 GO:0016266 O-glycan processing(GO:0016266)
1.9 5.6 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.0 5.4 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 4.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 3.8 GO:0009812 flavonoid metabolic process(GO:0009812)
0.1 3.8 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 3.3 GO:0007586 digestion(GO:0007586)
0.1 2.9 GO:0010107 potassium ion import(GO:0010107)
0.2 2.6 GO:0046541 saliva secretion(GO:0046541)
0.2 2.5 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 2.5 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 2.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 2.4 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.6 2.3 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 1.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.5 1.6 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.1 1.6 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.2 1.4 GO:0035609 C-terminal protein deglutamylation(GO:0035609)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.8 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 2.8 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 2.5 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 1.3 GO:0034451 centriolar satellite(GO:0034451)
0.4 1.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.2 1.1 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.1 GO:0070652 HAUS complex(GO:0070652)
0.0 1.1 GO:0043194 axon initial segment(GO:0043194)
0.0 1.1 GO:0042101 T cell receptor complex(GO:0042101)
0.1 1.0 GO:0002177 manchette(GO:0002177)
0.1 1.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 1.0 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.0 0.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.8 GO:0036157 outer dynein arm(GO:0036157)
0.0 0.8 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.0 0.8 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 0.8 GO:0030286 dynein complex(GO:0030286)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 5.2 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
1.3 5.0 GO:0004031 aldehyde oxidase activity(GO:0004031)
0.7 5.0 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
0.1 4.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 4.0 GO:0002162 dystroglycan binding(GO:0002162)
0.0 2.9 GO:0005178 integrin binding(GO:0005178)
0.2 2.8 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.9 2.7 GO:0046848 hydroxyapatite binding(GO:0046848)
0.6 2.4 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1 2.4 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 2.1 GO:0032393 MHC class I receptor activity(GO:0032393)
0.3 2.0 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 2.0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712)
0.0 1.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 1.8 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.1 1.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.7 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.4 1.4 GO:1904493 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.0 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.5 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.0 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.9 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.6 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.6 PID_IL6_7_PATHWAY IL6-mediated signaling events
0.0 0.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.3 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.1 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 9.3 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 6.2 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.2 6.0 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.4 5.5 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.2 4.9 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 4.4 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.1 3.2 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.7 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.5 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.1 1.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 1.4 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.0 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 1.0 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 0.9 REACTOME_DIGESTION_OF_DIETARY_CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.9 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.9 REACTOME_DOWNSTREAM_TCR_SIGNALING Genes involved in Downstream TCR signaling
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.8 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 0.7 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol