Motif ID: DBX2_HLX

Z-value: 0.603

Transcription factors associated with DBX2_HLX:

Gene SymbolEntrez IDGene Name
DBX2 ENSG00000185610.6 DBX2
HLX ENSG00000136630.11 HLX

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HLXhg19_v2_chr1_+_221051699_2210516990.174.2e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of DBX2_HLX

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_112564797 1.736 ENST00000398214.1
ENST00000448932.1
CD200R1L

CD200 receptor 1-like

chr20_-_7921090 1.591 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr4_-_110723194 1.336 ENST00000394635.3
CFI
complement factor I
chr22_+_23487513 1.301 ENST00000263116.2
ENST00000341989.4
RAB36

RAB36, member RAS oncogene family

chr11_-_63376013 1.243 ENST00000540943.1
PLA2G16
phospholipase A2, group XVI
chr9_+_12693336 1.225 ENST00000381137.2
ENST00000388918.5
TYRP1

tyrosinase-related protein 1

chr4_-_110723134 1.186 ENST00000510800.1
ENST00000512148.1
CFI

complement factor I

chr7_+_123241908 1.175 ENST00000434204.1
ENST00000437535.1
ENST00000451215.1
ASB15


ankyrin repeat and SOCS box containing 15


chr11_+_101918153 1.109 ENST00000434758.2
ENST00000526781.1
ENST00000534360.1
C11orf70


chromosome 11 open reading frame 70


chr1_-_197036364 1.057 ENST00000367412.1
F13B
coagulation factor XIII, B polypeptide
chr16_-_28634874 1.014 ENST00000395609.1
ENST00000350842.4
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr6_-_25874440 0.943 ENST00000361703.6
ENST00000397060.4
SLC17A3

solute carrier family 17 (organic anion transporter), member 3

chr21_+_33671264 0.935 ENST00000339944.4
MRAP
melanocortin 2 receptor accessory protein
chr9_-_34397800 0.903 ENST00000297623.2
C9orf24
chromosome 9 open reading frame 24
chr5_+_140227048 0.870 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr4_-_100356551 0.844 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr10_-_13043697 0.842 ENST00000378825.3
CCDC3
coiled-coil domain containing 3
chr10_+_32873190 0.834 ENST00000375025.4
C10orf68
Homo sapiens coiled-coil domain containing 7 (CCDC7), transcript variant 5, mRNA.
chr1_+_109256067 0.786 ENST00000271311.2
FNDC7
fibronectin type III domain containing 7
chr10_+_51549498 0.731 ENST00000358559.2
ENST00000298239.6
MSMB

microseminoprotein, beta-


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 112 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 2.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.7 GO:0016266 O-glycan processing(GO:0016266)
0.2 1.6 GO:0009441 glycolate metabolic process(GO:0009441)
0.5 1.4 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.2 1.4 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.1 1.3 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1 1.2 GO:0046485 ether lipid metabolic process(GO:0046485)
0.1 1.2 GO:0070986 left/right axis specification(GO:0070986)
0.1 1.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.1 0.9 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.9 GO:0009812 flavonoid metabolic process(GO:0009812)
0.0 0.9 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.8 GO:0044458 motile cilium assembly(GO:0044458)
0.1 0.7 GO:0019317 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.0 0.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.7 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.0 0.7 GO:0030449 regulation of complement activation(GO:0030449)
0.2 0.6 GO:0051097 negative regulation of helicase activity(GO:0051097)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.8 GO:0044439 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0 1.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 1.3 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.2 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.2 GO:0031526 brush border membrane(GO:0031526)
0.2 0.9 GO:0097224 sperm connecting piece(GO:0097224)
0.1 0.5 GO:1990131 Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.4 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.1 0.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 0.4 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.3 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.2 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.0 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 2.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 1.2 GO:0019770 IgG receptor activity(GO:0019770)
0.2 1.2 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1 1.0 GO:0050294 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 1.0 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.0 GO:0005507 copper ion binding(GO:0005507)
0.3 0.9 GO:0031783 corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783)
0.1 0.9 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.1 0.9 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.7 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 0.6 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.5 GO:1904493 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
0.0 0.5 GO:0004875 complement receptor activity(GO:0004875)
0.0 0.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.1 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.2 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.1 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.2 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.8 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 1.4 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 1.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 0.8 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.7 REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS Genes involved in Recycling of bile acids and salts
0.0 0.7 REACTOME_XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.2 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.0 0.1 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING Genes involved in GRB2 events in ERBB2 signaling