Motif ID: DBX2_HLX
Z-value: 0.603


Transcription factors associated with DBX2_HLX:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
DBX2 | ENSG00000185610.6 | DBX2 |
HLX | ENSG00000136630.11 | HLX |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
HLX | hg19_v2_chr1_+_221051699_221051699 | 0.17 | 4.2e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 112 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 3.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.0 | 2.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
0.0 | 1.7 | GO:0016266 | O-glycan processing(GO:0016266) |
0.2 | 1.6 | GO:0009441 | glycolate metabolic process(GO:0009441) |
0.5 | 1.4 | GO:0010430 | fatty acid omega-oxidation(GO:0010430) |
0.2 | 1.4 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
0.1 | 1.3 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
0.1 | 1.2 | GO:0046485 | ether lipid metabolic process(GO:0046485) |
0.1 | 1.2 | GO:0070986 | left/right axis specification(GO:0070986) |
0.1 | 1.2 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
0.1 | 0.9 | GO:0048014 | Tie signaling pathway(GO:0048014) |
0.1 | 0.9 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
0.0 | 0.9 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
0.0 | 0.9 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.0 | 0.8 | GO:0044458 | motile cilium assembly(GO:0044458) |
0.1 | 0.7 | GO:0019317 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
0.0 | 0.7 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
0.0 | 0.7 | GO:0060285 | cilium-dependent cell motility(GO:0060285) |
0.0 | 0.7 | GO:0030449 | regulation of complement activation(GO:0030449) |
0.2 | 0.6 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 36 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 2.8 | GO:0005796 | Golgi lumen(GO:0005796) |
0.0 | 1.8 | GO:0044439 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) microbody part(GO:0044438) peroxisomal part(GO:0044439) |
0.0 | 1.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
0.1 | 1.3 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
0.0 | 1.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
0.0 | 1.2 | GO:0009925 | basal plasma membrane(GO:0009925) |
0.0 | 1.2 | GO:0031526 | brush border membrane(GO:0031526) |
0.2 | 0.9 | GO:0097224 | sperm connecting piece(GO:0097224) |
0.1 | 0.5 | GO:1990131 | Gtr1-Gtr2 GTPase complex(GO:1990131) |
0.1 | 0.4 | GO:0097598 | sperm cytoplasmic droplet(GO:0097598) |
0.1 | 0.4 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
0.1 | 0.4 | GO:0036021 | endolysosome lumen(GO:0036021) |
0.0 | 0.4 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
0.0 | 0.4 | GO:0032585 | multivesicular body membrane(GO:0032585) |
0.0 | 0.3 | GO:0000439 | core TFIIH complex(GO:0000439) |
0.0 | 0.3 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
0.0 | 0.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
0.1 | 0.2 | GO:0043159 | acrosomal matrix(GO:0043159) |
0.0 | 0.2 | GO:0030485 | smooth muscle contractile fiber(GO:0030485) |
0.0 | 0.2 | GO:1990712 | HFE-transferrin receptor complex(GO:1990712) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 64 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 3.0 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
0.0 | 2.0 | GO:0005044 | scavenger receptor activity(GO:0005044) |
0.0 | 1.3 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
0.0 | 1.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
0.3 | 1.2 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.2 | 1.2 | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740) |
0.1 | 1.0 | GO:0050294 | flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294) |
0.0 | 1.0 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
0.0 | 1.0 | GO:0005507 | copper ion binding(GO:0005507) |
0.3 | 0.9 | GO:0031783 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) |
0.1 | 0.9 | GO:0015562 | efflux transmembrane transporter activity(GO:0015562) |
0.1 | 0.9 | GO:0032027 | myosin light chain binding(GO:0032027) |
0.0 | 0.9 | GO:0005035 | tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035) |
0.0 | 0.7 | GO:0008417 | fucosyltransferase activity(GO:0008417) |
0.1 | 0.6 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
0.0 | 0.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.6 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.1 | 0.5 | GO:1904493 | Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493) |
0.0 | 0.5 | GO:0004875 | complement receptor activity(GO:0004875) |
0.0 | 0.5 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
Gene overrepresentation in C2:CP category:
Showing 1 to 5 of 5 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 2.6 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
0.0 | 1.1 | PID_SHP2_PATHWAY | SHP2 signaling |
0.0 | 0.4 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.0 | 0.2 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
0.0 | 0.1 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 21 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.2 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.1 | 1.8 | REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
0.1 | 1.4 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
0.0 | 1.3 | REACTOME_GLUTATHIONE_CONJUGATION | Genes involved in Glutathione conjugation |
0.1 | 1.2 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PS | Genes involved in Acyl chain remodelling of PS |
0.1 | 0.8 | REACTOME_COMMON_PATHWAY | Genes involved in Common Pathway |
0.0 | 0.7 | REACTOME_RECYCLING_OF_BILE_ACIDS_AND_SALTS | Genes involved in Recycling of bile acids and salts |
0.0 | 0.7 | REACTOME_XENOBIOTICS | Genes involved in Xenobiotics |
0.0 | 0.6 | REACTOME_ANDROGEN_BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
0.0 | 0.6 | REACTOME_TIE2_SIGNALING | Genes involved in Tie2 Signaling |
0.0 | 0.5 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
0.0 | 0.4 | REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
0.0 | 0.4 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
0.0 | 0.4 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
0.0 | 0.4 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 0.4 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.0 | 0.2 | REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
0.0 | 0.2 | REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
0.0 | 0.2 | REACTOME_CS_DS_DEGRADATION | Genes involved in CS/DS degradation |
0.0 | 0.1 | REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING | Genes involved in GRB2 events in ERBB2 signaling |