Motif ID: CUX2

Z-value: 1.104


Transcription factors associated with CUX2:

Gene SymbolEntrez IDGene Name
CUX2 ENSG00000111249.9 CUX2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CUX2hg19_v2_chr12_+_111471828_1114719750.029.2e-01Click!


Activity profile for motif CUX2.

activity profile for motif CUX2


Sorted Z-values histogram for motif CUX2

Sorted Z-values for motif CUX2



Network of associatons between targets according to the STRING database.



First level regulatory network of CUX2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_100354442 2.459 ENST00000475887.1
GPR128
G protein-coupled receptor 128
chr7_-_23510086 2.151 ENST00000258729.3
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr2_-_216257849 2.011 ENST00000456923.1
FN1
fibronectin 1
chr1_-_109618566 1.854 ENST00000338366.5
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr19_-_22379753 1.624 ENST00000397121.2
ZNF676
zinc finger protein 676
chr9_+_105757590 1.390 ENST00000374798.3
ENST00000487798.1
CYLC2

cylicin, basic protein of sperm head cytoskeleton 2

chr9_+_35673853 1.326 ENST00000378357.4
CA9
carbonic anhydrase IX
chrX_+_55246818 1.321 ENST00000374952.1
PAGE5
P antigen family, member 5 (prostate associated)
chr22_+_38071615 1.310 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr4_+_69681710 1.210 ENST00000265403.7
ENST00000458688.2
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr6_+_151561085 1.203 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr16_+_30064411 1.195 ENST00000338110.5
ALDOA
aldolase A, fructose-bisphosphate
chr12_-_10978957 1.124 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr8_-_62559366 1.116 ENST00000522919.1
ASPH
aspartate beta-hydroxylase
chr17_+_7942335 1.097 ENST00000380183.4
ENST00000572022.1
ENST00000380173.2
ALOX15B


arachidonate 15-lipoxygenase, type B


chr8_-_91095099 1.089 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr4_+_69962185 1.083 ENST00000305231.7
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr4_+_69962212 1.067 ENST00000508661.1
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr16_+_30064444 1.028 ENST00000395248.1
ENST00000566897.1
ENST00000568435.1
ALDOA


aldolase A, fructose-bisphosphate


chr19_+_45409011 0.975 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
APOE


apolipoprotein E



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 175 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 2.4 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 2.2 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 2.1 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.7 2.0 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.6 1.7 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.0 1.7 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 1.6 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 1.6 GO:0036315 cellular response to sterol(GO:0036315)
0.4 1.5 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.3 1.3 GO:0071400 cellular response to oleic acid(GO:0071400)
0.3 1.3 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.3 1.3 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 1.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.3 1.2 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 1.2 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 1.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.2 1.1 GO:0051122 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.1 1.1 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.1 1.1 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.2 2.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 2.0 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.8 GO:0005901 caveola(GO:0005901)
0.6 1.7 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.0 1.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.5 1.4 GO:0033150 cytoskeletal calyx(GO:0033150)
0.0 1.4 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.3 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 1.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.3 GO:0043195 terminal bouton(GO:0043195)
0.1 1.1 GO:0008091 spectrin(GO:0008091)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.3 1.0 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.2 1.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 1.0 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 1.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.9 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.9 GO:0043679 axon terminus(GO:0043679)
0.0 0.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 2.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 2.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 2.0 GO:0016504 peptidase activator activity(GO:0016504)
0.4 1.7 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.7 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 1.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 1.4 GO:0033038 bitter taste receptor activity(GO:0033038)
0.4 1.3 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.4 1.3 GO:0004597 peptide-aspartate beta-dioxygenase activity(GO:0004597)
0.3 1.3 GO:0030395 lactose binding(GO:0030395)
0.2 1.3 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 1.2 GO:0008142 oxysterol binding(GO:0008142)
0.1 1.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.2 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.2 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 1.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.2 1.1 GO:0005499 vitamin D binding(GO:0005499)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.0 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 1.5 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 1.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.0 1.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.9 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.8 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.8 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.0 0.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.7 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.6 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.6 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.6 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.5 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.4 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.4 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 2.6 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.1 2.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 2.4 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 2.2 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 2.1 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 1.9 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.7 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 1.3 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 1.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.3 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.2 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.2 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 1.0 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.0 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.0 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.9 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.0 0.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.6 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle