Motif ID: CBFB

Z-value: 0.383


Transcription factors associated with CBFB:

Gene SymbolEntrez IDGene Name
CBFB ENSG00000067955.9 CBFB

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67062996_670630190.377.6e-02Click!


Activity profile for motif CBFB.

activity profile for motif CBFB


Sorted Z-values histogram for motif CBFB

Sorted Z-values for motif CBFB



Network of associatons between targets according to the STRING database.



First level regulatory network of CBFB

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_44637526 0.921 ENST00000372330.3
 MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr14_+_85996471 0.640 ENST00000330753.4
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr5_-_39203093 0.484 ENST00000515010.1
 FYB
FYN binding protein
chr19_-_14049184 0.418 ENST00000339560.5
 PODNL1
podocan-like 1
chr20_+_62492566 0.415 ENST00000369916.3
 ABHD16B
abhydrolase domain containing 16B
chr19_-_14048804 0.394 ENST00000254320.3
ENST00000586075.1
 PODNL1

podocan-like 1

chr1_+_47264711 0.357 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1


cytochrome P450, family 4, subfamily B, polypeptide 1


chr2_-_158300556 0.347 ENST00000264192.3
 CYTIP
cytohesin 1 interacting protein
chr14_+_85996507 0.331 ENST00000554746.1
 FLRT2
fibronectin leucine rich transmembrane protein 2
chr6_-_34524049 0.281 ENST00000374037.3
 SPDEF
SAM pointed domain containing ETS transcription factor
chr11_-_58343319 0.268 ENST00000395074.2
 LPXN
leupaxin
chr6_-_34524093 0.260 ENST00000544425.1
 SPDEF
SAM pointed domain containing ETS transcription factor
chr3_-_99569821 0.246 ENST00000487087.1
 FILIP1L
filamin A interacting protein 1-like
chr1_-_52499443 0.233 ENST00000371614.1
 KTI12
KTI12 homolog, chromatin associated (S. cerevisiae)
chr20_+_43343886 0.214 ENST00000190983.4
 WISP2
WNT1 inducible signaling pathway protein 2
chr11_-_66103867 0.203 ENST00000424433.2
 RIN1
Ras and Rab interactor 1
chr11_+_114310164 0.200 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
 REXO2


RNA exonuclease 2


chr8_-_60031762 0.200 ENST00000361421.1
 TOX
thymocyte selection-associated high mobility group box
chr1_-_179112173 0.198 ENST00000408940.3
ENST00000504405.1
 ABL2

c-abl oncogene 2, non-receptor tyrosine kinase

chr14_-_85996332 0.184 ENST00000380722.1
 RP11-497E19.1
RP11-497E19.1
chr11_-_66104237 0.180 ENST00000530056.1
 RIN1
Ras and Rab interactor 1
chr6_+_42847649 0.178 ENST00000424341.2
ENST00000602561.1
 RPL7L1

ribosomal protein L7-like 1

chr11_+_114310102 0.165 ENST00000265881.5
 REXO2
RNA exonuclease 2
chr3_+_132843652 0.160 ENST00000508711.1
 TMEM108
transmembrane protein 108
chr11_-_66103932 0.160 ENST00000311320.4
 RIN1
Ras and Rab interactor 1
chr14_+_22748980 0.153 ENST00000390465.2
 TRAV38-2DV8
T cell receptor alpha variable 38-2/delta variable 8
chr20_+_54987305 0.152 ENST00000371336.3
ENST00000434344.1
 CASS4

Cas scaffolding protein family member 4

chrX_+_68048803 0.150 ENST00000204961.4
 EFNB1
ephrin-B1
chr12_-_52585765 0.149 ENST00000313234.5
ENST00000394815.2
 KRT80

keratin 80

chr17_-_39183452 0.148 ENST00000361883.5
 KRTAP1-5
keratin associated protein 1-5
chr12_-_14849470 0.146 ENST00000261170.3
 GUCY2C
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr11_+_114310237 0.141 ENST00000539119.1
 REXO2
RNA exonuclease 2
chr20_+_54987168 0.135 ENST00000360314.3
 CASS4
Cas scaffolding protein family member 4
chr12_-_54778471 0.125 ENST00000550120.1
ENST00000394313.2
ENST00000547210.1
 ZNF385A


zinc finger protein 385A


chrX_+_115567767 0.123 ENST00000371900.4
 SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chr6_-_75912508 0.112 ENST00000416123.2
 COL12A1
collagen, type XII, alpha 1
chr14_-_35183886 0.109 ENST00000298159.6
 CFL2
cofilin 2 (muscle)
chr10_-_29811456 0.103 ENST00000535393.1
 SVIL
supervillin
chr12_-_4754339 0.098 ENST00000228850.1
 AKAP3
A kinase (PRKA) anchor protein 3
chr15_-_64665911 0.097 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
 CTD-2116N17.1


Uncharacterized protein


chr5_+_131409476 0.093 ENST00000296871.2
 CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr22_+_42665742 0.087 ENST00000332965.3
ENST00000415205.1
ENST00000446578.1
 Z83851.3


Z83851.3


chr14_-_59950724 0.085 ENST00000481608.1
 L3HYPDH
L-3-hydroxyproline dehydratase (trans-)
chr6_+_29068386 0.083 ENST00000377171.3
 OR2J1
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr1_+_89246647 0.075 ENST00000544045.1
 PKN2
protein kinase N2
chrX_-_49041242 0.072 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
 PRICKLE3



prickle homolog 3 (Drosophila)



chr2_+_234826016 0.070 ENST00000324695.4
ENST00000433712.2
 TRPM8

transient receptor potential cation channel, subfamily M, member 8

chr2_+_68592305 0.069 ENST00000234313.7
 PLEK
pleckstrin
chr12_-_53594227 0.066 ENST00000550743.2
 ITGB7
integrin, beta 7
chr3_-_71834318 0.064 ENST00000353065.3
 PROK2
prokineticin 2
chr9_+_15422702 0.050 ENST00000380821.3
ENST00000421710.1
 SNAPC3

small nuclear RNA activating complex, polypeptide 3, 50kDa

chr1_+_39876151 0.044 ENST00000530275.1
 KIAA0754
KIAA0754
chr5_-_137878887 0.043 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
 ETF1



eukaryotic translation termination factor 1



chr3_+_156799587 0.043 ENST00000469196.1
 RP11-6F2.5
RP11-6F2.5
chr15_+_73976545 0.036 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
 CD276


CD276 molecule


chr4_+_74347400 0.035 ENST00000226355.3
 AFM
afamin
chrX_-_70838306 0.035 ENST00000373691.4
ENST00000373693.3
 CXCR3

chemokine (C-X-C motif) receptor 3

chr4_+_71091786 0.034 ENST00000317987.5
 FDCSP
follicular dendritic cell secreted protein
chr2_+_207024306 0.033 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
 EEF1B2



eukaryotic translation elongation factor 1 beta 2



chr11_+_18343800 0.033 ENST00000453096.2
 GTF2H1
general transcription factor IIH, polypeptide 1, 62kDa
chr6_+_27925019 0.032 ENST00000244623.1
 OR2B6
olfactory receptor, family 2, subfamily B, member 6
chr8_+_104384616 0.030 ENST00000520337.1
 CTHRC1
collagen triple helix repeat containing 1
chr15_+_64386261 0.027 ENST00000560829.1
 SNX1
sorting nexin 1
chr22_+_23222886 0.027 ENST00000390319.2
 IGLV3-1
immunoglobulin lambda variable 3-1
chr1_+_196621002 0.024 ENST00000367429.4
ENST00000439155.2
 CFH

complement factor H

chr14_+_72064945 0.021 ENST00000537413.1
 SIPA1L1
signal-induced proliferation-associated 1 like 1
chr1_-_157014865 0.021 ENST00000361409.2
 ARHGEF11
Rho guanine nucleotide exchange factor (GEF) 11
chr1_-_240775447 0.019 ENST00000318160.4
 GREM2
gremlin 2, DAN family BMP antagonist
chr8_-_28747424 0.018 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
 INTS9




integrator complex subunit 9




chr17_+_32582293 0.017 ENST00000580907.1
ENST00000225831.4
 CCL2

chemokine (C-C motif) ligand 2

chrX_-_153718988 0.015 ENST00000263512.4
ENST00000393587.4
ENST00000453912.1
 SLC10A3


solute carrier family 10, member 3


chr8_-_28747717 0.014 ENST00000416984.2
 INTS9
integrator complex subunit 9
chr13_+_76210448 0.013 ENST00000377499.5
 LMO7
LIM domain 7
chr1_+_17634689 0.008 ENST00000375453.1
ENST00000375448.4
 PADI4

peptidyl arginine deiminase, type IV


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.9 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.1 0.5 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.5 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.1 0.4 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 0.3 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.1 GO:1902162 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902162) positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator(GO:1902164)
0.0 0.1 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.0 0.1 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.1 GO:0050955 thermoception(GO:0050955)
0.0 0.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0070560 protein secretion by platelet(GO:0070560)
0.0 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.8 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030934 anchoring collagen complex(GO:0030934)
0.0 0.1 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.9 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 0.5 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0036361 racemase and epimerase activity, acting on amino acids and derivatives(GO:0016855) racemase activity, acting on amino acids and derivatives(GO:0036361) amino-acid racemase activity(GO:0047661)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID_AVB3_OPN_PATHWAY Osteopontin-mediated events
0.0 0.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions