Motif ID: BRCA1

Z-value: 0.392


Transcription factors associated with BRCA1:

Gene SymbolEntrez IDGene Name
BRCA1 ENSG00000012048.15 BRCA1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277317_41277348-0.405.5e-02Click!


Activity profile for motif BRCA1.

activity profile for motif BRCA1


Sorted Z-values histogram for motif BRCA1

Sorted Z-values for motif BRCA1



Network of associatons between targets according to the STRING database.



First level regulatory network of BRCA1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_+_55888186 1.505 ENST00000291934.3
 TMEM190
transmembrane protein 190
chr20_+_9049682 1.361 ENST00000334005.3
ENST00000378473.3
 PLCB4

phospholipase C, beta 4

chr20_+_31749574 0.808 ENST00000253362.2
 BPIFA2
BPI fold containing family A, member 2
chr7_-_6010263 0.667 ENST00000455618.2
ENST00000405415.1
ENST00000404406.1
ENST00000542644.1
 RSPH10B



radial spoke head 10 homolog B (Chlamydomonas)



chr1_-_160232312 0.650 ENST00000440682.1
 DCAF8
DDB1 and CUL4 associated factor 8
chr8_+_37553261 0.634 ENST00000331569.4
 ZNF703
zinc finger protein 703
chr17_-_42019836 0.609 ENST00000225992.3
 PPY
pancreatic polypeptide
chr5_+_140186647 0.607 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4


protocadherin alpha 4


chr6_+_16129308 0.606 ENST00000356840.3
ENST00000349606.4
 MYLIP

myosin regulatory light chain interacting protein

chr1_-_227505289 0.486 ENST00000366765.3
 CDC42BPA
CDC42 binding protein kinase alpha (DMPK-like)
chr20_+_52105495 0.473 ENST00000439873.2
 AL354993.1
Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr9_-_124976154 0.457 ENST00000482062.1
 LHX6
LIM homeobox 6
chr6_+_12717892 0.429 ENST00000379350.1
 PHACTR1
phosphatase and actin regulator 1
chr8_-_72459885 0.382 ENST00000523987.1
 RP11-1102P16.1
Uncharacterized protein
chr13_-_99910673 0.364 ENST00000397473.2
ENST00000397470.2
 GPR18

G protein-coupled receptor 18

chr11_-_119234876 0.335 ENST00000525735.1
 USP2
ubiquitin specific peptidase 2
chr10_-_61900762 0.314 ENST00000355288.2
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr5_+_139027877 0.279 ENST00000302517.3
 CXXC5
CXXC finger protein 5
chrX_-_10851762 0.278 ENST00000380785.1
ENST00000380787.1
 MID1

midline 1 (Opitz/BBB syndrome)

chr12_-_49449107 0.261 ENST00000301067.7
 KMT2D
lysine (K)-specific methyltransferase 2D
chr3_-_27410847 0.258 ENST00000429845.2
ENST00000341435.5
ENST00000435750.1
 NEK10


NIMA-related kinase 10


chr3_+_184056614 0.257 ENST00000453072.1
 FAM131A
family with sequence similarity 131, member A
chr12_-_122879969 0.244 ENST00000540304.1
 CLIP1
CAP-GLY domain containing linker protein 1
chr7_-_121944491 0.244 ENST00000331178.4
ENST00000427185.2
ENST00000442488.2
 FEZF1


FEZ family zinc finger 1


chr17_-_56296580 0.234 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
 MKS1



Meckel syndrome, type 1



chr17_-_27230035 0.231 ENST00000378895.4
ENST00000394901.3
 DHRS13

dehydrogenase/reductase (SDR family) member 13

chr1_-_160232291 0.226 ENST00000368074.1
ENST00000447377.1
 DCAF8

DDB1 and CUL4 associated factor 8

chr1_-_217250231 0.225 ENST00000493748.1
ENST00000463665.1
 ESRRG

estrogen-related receptor gamma

chrX_+_10124977 0.220 ENST00000380833.4
 CLCN4
chloride channel, voltage-sensitive 4
chr5_+_145583107 0.215 ENST00000506502.1
 RBM27
RNA binding motif protein 27
chr1_-_160232197 0.211 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
 DCAF8





DDB1 and CUL4 associated factor 8





chr10_-_69597810 0.207 ENST00000483798.2
 DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr4_+_619347 0.204 ENST00000255622.6
 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr5_+_145583156 0.203 ENST00000265271.5
 RBM27
RNA binding motif protein 27
chr1_+_159141397 0.193 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
 CADM3


cell adhesion molecule 3


chr11_-_27722021 0.190 ENST00000356660.4
ENST00000418212.1
ENST00000533246.1
 BDNF


brain-derived neurotrophic factor


chr1_-_170043709 0.163 ENST00000367767.1
ENST00000361580.2
ENST00000538366.1
 KIFAP3


kinesin-associated protein 3


chr17_-_8702667 0.153 ENST00000329805.4
 MFSD6L
major facilitator superfamily domain containing 6-like
chrX_-_46187069 0.147 ENST00000446884.1
 RP1-30G7.2
RP1-30G7.2
chr18_-_49557 0.147 ENST00000308911.6
 RP11-683L23.1
Tubulin beta-8 chain-like protein LOC260334
chr14_-_75179774 0.146 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
 AREL1


AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1


Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr12_+_510742 0.142 ENST00000239830.4
 CCDC77
coiled-coil domain containing 77
chr12_+_510795 0.140 ENST00000412006.2
 CCDC77
coiled-coil domain containing 77
chr10_+_93683519 0.139 ENST00000265990.6
 BTAF1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
chr2_-_152118352 0.139 ENST00000331426.5
 RBM43
RNA binding motif protein 43
chrX_+_49644470 0.137 ENST00000508866.2
 USP27X
ubiquitin specific peptidase 27, X-linked
chr20_-_48530230 0.132 ENST00000422556.1
 SPATA2
spermatogenesis associated 2
chr7_+_99717230 0.132 ENST00000262932.3
 CNPY4
canopy FGF signaling regulator 4
chr5_+_140079919 0.130 ENST00000274712.3
 ZMAT2
zinc finger, matrin-type 2
chr11_-_110583912 0.130 ENST00000533353.1
ENST00000527598.1
 ARHGAP20

Rho GTPase activating protein 20

chr13_-_50018140 0.128 ENST00000410043.1
ENST00000347776.5
 CAB39L

calcium binding protein 39-like

chr13_+_103046954 0.127 ENST00000606448.1
 FGF14-AS2
FGF14 antisense RNA 2
chr11_+_47291645 0.122 ENST00000395336.3
ENST00000402192.2
 MADD

MAP-kinase activating death domain

chr4_-_140005443 0.120 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
 ELF2


E74-like factor 2 (ets domain transcription factor)


chr13_+_30002846 0.120 ENST00000542829.1
 MTUS2
microtubule associated tumor suppressor candidate 2
chr17_-_60142609 0.120 ENST00000397786.2
 MED13
mediator complex subunit 13
chr10_+_102295616 0.117 ENST00000299163.6
 HIF1AN
hypoxia inducible factor 1, alpha subunit inhibitor
chr1_-_232598163 0.115 ENST00000308942.4
 SIPA1L2
signal-induced proliferation-associated 1 like 2
chr2_-_158182410 0.113 ENST00000419116.2
ENST00000410096.1
 ERMN

ermin, ERM-like protein

chr2_-_25194476 0.111 ENST00000534855.1
 DNAJC27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr6_+_33172407 0.110 ENST00000374662.3
 HSD17B8
hydroxysteroid (17-beta) dehydrogenase 8
chr17_+_21730180 0.109 ENST00000584398.1
 UBBP4
ubiquitin B pseudogene 4
chr4_+_619386 0.108 ENST00000496514.1
 PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr10_+_104404644 0.103 ENST00000462202.2
 TRIM8
tripartite motif containing 8
chr8_-_116681221 0.100 ENST00000395715.3
 TRPS1
trichorhinophalangeal syndrome I
chr11_+_47291193 0.096 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
 MADD







MAP-kinase activating death domain







chr6_+_123100620 0.096 ENST00000368444.3
 FABP7
fatty acid binding protein 7, brain
chr2_-_179914760 0.090 ENST00000420890.2
ENST00000409284.1
ENST00000443758.1
ENST00000446116.1
 CCDC141



coiled-coil domain containing 141



chr16_-_790887 0.089 ENST00000540986.1
 NARFL
nuclear prelamin A recognition factor-like
chr5_+_139493665 0.087 ENST00000331327.3
 PURA
purine-rich element binding protein A
chr16_-_790982 0.087 ENST00000301694.5
ENST00000251588.2
 NARFL

nuclear prelamin A recognition factor-like

chr19_-_37663332 0.078 ENST00000392157.2
 ZNF585A
zinc finger protein 585A
chr1_+_161736072 0.075 ENST00000367942.3
 ATF6
activating transcription factor 6
chr10_-_69597828 0.067 ENST00000339758.7
 DNAJC12
DnaJ (Hsp40) homolog, subfamily C, member 12
chr7_+_73868439 0.066 ENST00000424337.2
 GTF2IRD1
GTF2I repeat domain containing 1
chr14_-_60097524 0.054 ENST00000342503.4
 RTN1
reticulon 1
chr9_+_35792151 0.052 ENST00000342694.2
 NPR2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr10_+_92631709 0.048 ENST00000413330.1
ENST00000277882.3
 RPP30

ribonuclease P/MRP 30kDa subunit

chr5_-_68665296 0.046 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
 TAF9



TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa



chr13_+_27825706 0.046 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
 RPL21


ribosomal protein L21


chr19_-_37663572 0.043 ENST00000588354.1
ENST00000292841.5
ENST00000355533.2
ENST00000356958.4
 ZNF585A



zinc finger protein 585A



chr14_-_60097297 0.041 ENST00000395090.1
 RTN1
reticulon 1
chr13_+_30002741 0.036 ENST00000380808.2
 MTUS2
microtubule associated tumor suppressor candidate 2
chr10_-_102289611 0.030 ENST00000535773.1
ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
 SEC31B
NDUFB8



SEC31 homolog B (S. cerevisiae)
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa



chr12_+_122880045 0.029 ENST00000539034.1
ENST00000535976.1
 RP11-450K4.1

RP11-450K4.1

chr18_-_23671139 0.028 ENST00000579061.1
ENST00000542420.2
 SS18

synovial sarcoma translocation, chromosome 18

chr17_-_7082861 0.028 ENST00000269299.3
 ASGR1
asialoglycoprotein receptor 1
chr15_-_58358607 0.023 ENST00000249750.4
 ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr1_+_10271674 0.022 ENST00000377086.1
 KIF1B
kinesin family member 1B
chr8_-_16859690 0.020 ENST00000180166.5
 FGF20
fibroblast growth factor 20
chr18_+_55888767 0.020 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
 NEDD4L


neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase


chr3_+_185303962 0.019 ENST00000296257.5
 SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr1_+_160147176 0.011 ENST00000470705.1
 ATP1A4
ATPase, Na+/K+ transporting, alpha 4 polypeptide
chrX_-_77150985 0.011 ENST00000358075.6
 MAGT1
magnesium transporter 1
chr6_-_137314371 0.009 ENST00000432330.1
ENST00000418699.1
 RP11-55K22.5

RP11-55K22.5

chr6_+_42981922 0.005 ENST00000326974.4
ENST00000244670.8
 KLHDC3

kelch domain containing 3

chrX_-_77150911 0.000 ENST00000373336.3
 MAGT1
magnesium transporter 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.1 0.3 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.2 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.1 0.2 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.0 0.2 GO:0044861 protein transport into plasma membrane raft(GO:0044861)
0.0 0.6 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 0.2 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.2 GO:0061009 common bile duct development(GO:0061009)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.2 GO:0001555 oocyte growth(GO:0001555)
0.0 0.4 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.1 GO:0045204 MAPK export from nucleus(GO:0045204)
0.0 0.3 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.6 GO:0032098 regulation of appetite(GO:0032098)
0.0 0.1 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.2 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 1.4 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0002079 inner acrosomal membrane(GO:0002079)
0.0 0.2 GO:1990075 kinesin II complex(GO:0016939) periciliary membrane compartment(GO:1990075)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 1.4 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 1.1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0097361 CIA complex(GO:0097361)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.3 GO:0097381 photoreceptor disc membrane(GO:0097381)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.0 1.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0070404 NADH binding(GO:0070404)
0.0 1.5 GO:0043621 protein self-association(GO:0043621)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.7 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.1 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.0 0.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events