Motif ID: BHLHE40

Z-value: 0.735


Transcription factors associated with BHLHE40:

Gene SymbolEntrez IDGene Name
BHLHE40 ENSG00000134107.4 BHLHE40

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BHLHE40hg19_v2_chr3_+_5020801_50209520.471.9e-02Click!


Activity profile for motif BHLHE40.

activity profile for motif BHLHE40


Sorted Z-values histogram for motif BHLHE40

Sorted Z-values for motif BHLHE40



Network of associatons between targets according to the STRING database.



First level regulatory network of BHLHE40

PNG image of the network

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Top targets:


Showing 1 to 20 of 180 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_35645618 2.709 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
 FXYD5






FXYD domain containing ion transport regulator 5






chr12_-_25102252 2.682 ENST00000261192.7
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr19_+_35645817 2.213 ENST00000423817.3
 FXYD5
FXYD domain containing ion transport regulator 5
chr12_-_25101920 2.181 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr12_+_66217911 1.444 ENST00000403681.2
 HMGA2
high mobility group AT-hook 2
chr1_-_200589859 1.403 ENST00000367350.4
 KIF14
kinesin family member 14
chr6_+_151561085 1.278 ENST00000402676.2
 AKAP12
A kinase (PRKA) anchor protein 12
chr4_-_159094194 1.063 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
 FAM198B


family with sequence similarity 198, member B


chr7_-_107642348 1.046 ENST00000393561.1
 LAMB1
laminin, beta 1
chr8_+_99129513 1.026 ENST00000522319.1
ENST00000401707.2
 POP1

processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)

chr1_-_113498943 1.000 ENST00000369626.3
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr8_+_32405728 0.991 ENST00000523079.1
ENST00000338921.4
ENST00000356819.4
ENST00000287845.5
ENST00000341377.5
 NRG1




neuregulin 1




chr8_+_32405785 0.971 ENST00000287842.3
 NRG1
neuregulin 1
chr17_+_40811283 0.904 ENST00000251412.7
 TUBG2
tubulin, gamma 2
chr11_+_60609537 0.872 ENST00000227520.5
 CCDC86
coiled-coil domain containing 86
chr21_-_45079341 0.862 ENST00000443485.1
ENST00000291560.2
 HSF2BP

heat shock transcription factor 2 binding protein

chr7_+_141463897 0.838 ENST00000247879.2
 TAS2R3
taste receptor, type 2, member 3
chr9_+_706842 0.830 ENST00000382293.3
 KANK1
KN motif and ankyrin repeat domains 1
chr1_-_231376836 0.826 ENST00000451322.1
 C1orf131
chromosome 1 open reading frame 131
chr1_-_43638168 0.771 ENST00000431635.2
 EBNA1BP2
EBNA1 binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 4.9 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
0.8 4.9 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.3 2.3 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.2 1.8 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.3 1.5 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.4 1.4 GO:0031052 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.3 1.4 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.0 1.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 1.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 1.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 1.2 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.3 1.0 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.3 1.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.1 1.0 GO:0016078 tRNA catabolic process(GO:0016078)
0.1 1.0 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.9 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.9 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.9 GO:0015914 phospholipid transport(GO:0015914)
0.3 0.8 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2 0.8 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0030673 axolemma(GO:0030673)
0.0 1.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.5 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 1.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.4 GO:0051233 spindle midzone(GO:0051233)
0.0 1.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.3 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 1.0 GO:0005607 laminin-2 complex(GO:0005607)
0.1 1.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.1 1.0 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.9 GO:0000242 pericentriolar material(GO:0000242)
0.2 0.8 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.1 0.7 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 0.7 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.0 0.6 GO:0045180 basal cortex(GO:0045180)
0.0 0.6 GO:0005922 connexon complex(GO:0005922)
0.0 0.5 GO:0030686 90S preribosome(GO:0030686)
0.0 0.5 GO:0043034 costamere(GO:0043034)
0.0 0.4 GO:0042583 chromaffin granule(GO:0042583)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 4.9 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 4.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 2.0 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.4 1.4 GO:0035501 MH1 domain binding(GO:0035501)
0.0 1.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 1.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.3 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 1.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.3 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.3 1.0 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
0.1 1.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.9 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.2 0.8 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.2 0.8 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.8 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.8 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 0.7 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.7 GO:0031014 troponin T binding(GO:0031014)
0.0 0.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 2.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.5 PID_MYC_PATHWAY C-MYC pathway
0.0 1.0 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.5 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.3 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.9 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 2.0 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 1.8 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 1.7 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.5 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 1.3 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.0 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.9 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 0.7 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.0 0.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.3 REACTOME_FORMATION_OF_INCISION_COMPLEX_IN_GG_NER Genes involved in Formation of incision complex in GG-NER
0.0 0.2 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs