Motif ID: BACH1_NFE2_NFE2L2

Z-value: 0.552

Transcription factors associated with BACH1_NFE2_NFE2L2:

Gene SymbolEntrez IDGene Name
BACH1 ENSG00000156273.11 BACH1
NFE2 ENSG00000123405.9 NFE2
NFE2L2 ENSG00000116044.11 NFE2L2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
BACH1hg19_v2_chr21_+_30671690_30671762,
hg19_v2_chr21_+_30671189_30671207		-0.368.2e-02Click!
NFE2hg19_v2_chr12_-_54691668_54691725-0.193.8e-01Click!
NFE2L2hg19_v2_chr2_-_178128250_178128300,
hg19_v2_chr2_-_178128528_178128574,
hg19_v2_chr2_-_178257401_178257432		-0.174.3e-01Click!


Activity profile for motif BACH1_NFE2_NFE2L2.

activity profile for motif BACH1_NFE2_NFE2L2


Sorted Z-values histogram for motif BACH1_NFE2_NFE2L2

Sorted Z-values for motif BACH1_NFE2_NFE2L2



Network of associatons between targets according to the STRING database.



First level regulatory network of BACH1_NFE2_NFE2L2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr22_+_19466980 0.696 ENST00000407835.1
ENST00000438587.1
 CDC45

cell division cycle 45

chr12_+_56075330 0.681 ENST00000394252.3
 METTL7B
methyltransferase like 7B
chr17_+_30771279 0.647 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
 PSMD11



proteasome (prosome, macropain) 26S subunit, non-ATPase, 11



chr10_+_134901388 0.428 ENST00000392607.3
 GPR123
G protein-coupled receptor 123
chr18_+_158513 0.423 ENST00000400266.3
ENST00000580410.1
ENST00000383589.2
ENST00000261601.7
 USP14



ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)



chr10_-_6019455 0.419 ENST00000530685.1
ENST00000397255.3
ENST00000379971.1
ENST00000528354.1
ENST00000397250.2
ENST00000429135.2
 IL15RA





interleukin 15 receptor, alpha





chr5_-_137911049 0.381 ENST00000297185.3
 HSPA9
heat shock 70kDa protein 9 (mortalin)
chr14_+_58711539 0.377 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
 PSMA3


proteasome (prosome, macropain) subunit, alpha type, 3


chr3_-_170588163 0.344 ENST00000295830.8
 RPL22L1
ribosomal protein L22-like 1
chr10_-_127505167 0.332 ENST00000368786.1
 UROS
uroporphyrinogen III synthase
chr22_+_39353527 0.312 ENST00000249116.2
 APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr3_+_184038073 0.309 ENST00000428387.1
ENST00000434061.2
 EIF4G1

eukaryotic translation initiation factor 4 gamma, 1

chr19_+_50706866 0.293 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
 MYH14




myosin, heavy chain 14, non-muscle




chr14_-_23624511 0.289 ENST00000529705.2
 SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr4_+_4388245 0.283 ENST00000433139.2
 NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr2_-_220173685 0.281 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
 PTPRN


protein tyrosine phosphatase, receptor type, N


chr3_+_184037466 0.266 ENST00000441154.1
 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr3_-_170587974 0.266 ENST00000463836.1
 RPL22L1
ribosomal protein L22-like 1
chr7_+_145813453 0.263 ENST00000361727.3
 CNTNAP2
contactin associated protein-like 2
chr1_-_200992827 0.261 ENST00000332129.2
ENST00000422435.2
 KIF21B

kinesin family member 21B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.2 0.7 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.6 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 0.4 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.1 0.4 GO:0071461 cellular response to redox state(GO:0071461)
0.0 0.4 GO:1902037 negative regulation of hematopoietic stem cell differentiation(GO:1902037)
0.0 0.4 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.3 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.1 0.3 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.3 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.3 GO:0070383 DNA cytosine deamination(GO:0070383)
0.1 0.3 GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0 0.3 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.3 GO:0046826 negative regulation of protein export from nucleus(GO:0046826)
0.0 0.3 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.3 GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane(GO:0098887)
0.1 0.2 GO:0090425 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.1 0.2 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 0.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.8 GO:0000502 proteasome complex(GO:0000502)
0.2 0.7 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 0.4 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.4 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.3 GO:0097513 myosin II filament(GO:0097513)
0.0 0.3 GO:0098845 postsynaptic endosome(GO:0098845)
0.0 0.3 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.3 GO:0033010 paranodal junction(GO:0033010)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.2 GO:0044753 amphisome(GO:0044753)
0.1 0.2 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.1 0.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.0 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.4 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.4 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.1 0.3 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.3 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.3 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 0.2 GO:0002134 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) sulfonylurea receptor binding(GO:0017098) pyrimidine ribonucleoside binding(GO:0032551)
0.1 0.2 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.1 0.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.0 0.2 GO:0070026 nitric oxide binding(GO:0070026)
0.0 0.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.2 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.6 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.5 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.5 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME_SIGNALING_BY_FGFR3_MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.2 REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors