Motif ID: ARNT

Z-value: 1.239


Transcription factors associated with ARNT:

Gene SymbolEntrez IDGene Name
ARNT ENSG00000143437.16 ARNT

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
ARNThg19_v2_chr1_-_150849174_150849200,
hg19_v2_chr1_-_150849047_150849085		0.795.3e-06Click!


Activity profile for motif ARNT.

activity profile for motif ARNT


Sorted Z-values histogram for motif ARNT

Sorted Z-values for motif ARNT



Network of associatons between targets according to the STRING database.



First level regulatory network of ARNT

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_173420697 6.302 ENST00000282077.3
ENST00000392571.2
ENST00000410055.1
 PDK1


pyruvate dehydrogenase kinase, isozyme 1


chr1_-_113498616 4.599 ENST00000433570.4
ENST00000538576.1
ENST00000458229.1
 SLC16A1


solute carrier family 16 (monocarboxylate transporter), member 1


chr6_+_151561506 3.803 ENST00000253332.1
 AKAP12
A kinase (PRKA) anchor protein 12
chr18_-_33077556 3.801 ENST00000589273.1
ENST00000586489.1
 INO80C

INO80 complex subunit C

chr15_+_40453204 3.713 ENST00000287598.6
ENST00000412359.3
 BUB1B

BUB1 mitotic checkpoint serine/threonine kinase B

chr1_-_113498943 3.638 ENST00000369626.3
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr7_-_128045984 3.603 ENST00000470772.1
ENST00000480861.1
ENST00000496200.1
 IMPDH1


IMP (inosine 5'-monophosphate) dehydrogenase 1


chrX_+_77359671 3.442 ENST00000373316.4
 PGK1
phosphoglycerate kinase 1
chrX_+_69509927 3.315 ENST00000374403.3
 KIF4A
kinesin family member 4A
chr15_+_45722727 3.291 ENST00000396650.2
ENST00000558435.1
ENST00000344300.3
 C15orf48


chromosome 15 open reading frame 48


chr11_+_72929319 3.230 ENST00000393597.2
ENST00000311131.2
 P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr22_+_40390930 3.223 ENST00000333407.6
 FAM83F
family with sequence similarity 83, member F
chr11_+_72929402 3.139 ENST00000393596.2
 P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr2_+_192543153 3.066 ENST00000425611.2
 NABP1
nucleic acid binding protein 1
chr19_+_1407733 3.045 ENST00000592453.1
 DAZAP1
DAZ associated protein 1
chr3_+_5020801 3.016 ENST00000256495.3
 BHLHE40
basic helix-loop-helix family, member e40
chr11_-_6341724 3.013 ENST00000530979.1
 PRKCDBP
protein kinase C, delta binding protein
chr9_-_123638633 2.918 ENST00000456291.1
 PHF19
PHD finger protein 19
chr9_+_35673853 2.889 ENST00000378357.4
 CA9
carbonic anhydrase IX
chr9_-_123639304 2.831 ENST00000436309.1
 PHF19
PHD finger protein 19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 8.2 GO:0051780 mevalonate transport(GO:0015728) behavioral response to nutrient(GO:0051780)
0.7 7.9 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.3 7.6 GO:0031639 plasminogen activation(GO:0031639)
0.5 7.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
1.0 7.2 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0 6.6 GO:0006338 chromatin remodeling(GO:0006338)
0.5 6.4 GO:0070257 positive regulation of mucus secretion(GO:0070257)
1.1 5.7 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1 5.3 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.7 4.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.2 3.9 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.9 3.7 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 3.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 3.4 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.2 3.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.5 3.2 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.8 3.1 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.0 3.1 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
1.0 3.0 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.4 3.0 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.4 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 6.9 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
1.6 6.3 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1 5.9 GO:0045171 intercellular bridge(GO:0045171)
0.0 5.3 GO:0005938 cell cortex(GO:0005938)
0.0 4.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 4.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 3.7 GO:0045121 membrane raft(GO:0045121)
0.0 3.5 GO:0001726 ruffle(GO:0001726)
0.5 3.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 3.3 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
1.1 3.2 GO:0005900 oncostatin-M receptor complex(GO:0005900)
0.0 3.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.6 3.1 GO:0070876 SOSS complex(GO:0070876)
0.1 3.1 GO:0036020 endolysosome membrane(GO:0036020)
0.1 3.1 GO:0031528 microvillus membrane(GO:0031528)
0.0 2.9 GO:0005811 lipid particle(GO:0005811)
0.1 2.8 GO:0005652 nuclear lamina(GO:0005652)
0.3 2.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 2.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 172 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 8.2 GO:0015130 mevalonate transmembrane transporter activity(GO:0015130)
1.8 7.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.4 6.5 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 6.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
2.0 6.0 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
0.1 5.3 GO:0035064 methylated histone binding(GO:0035064)
0.2 4.9 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 4.8 GO:0045296 cadherin binding(GO:0045296)
0.0 4.4 GO:0015631 tubulin binding(GO:0015631)
1.0 4.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.5 3.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 3.2 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.8 3.1 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.1 3.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
1.0 3.0 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.3 3.0 GO:0043426 MRF binding(GO:0043426)
0.3 3.0 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 2.8 GO:0004089 carbonate dehydratase activity(GO:0004089)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.4 7.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 5.5 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 4.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.6 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.9 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.9 PID_LKB1_PATHWAY LKB1 signaling events
0.0 2.7 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 2.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.4 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 2.1 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 2.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 1.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 1.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.7 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.1 1.4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.4 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 1.3 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.2 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 16.0 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.2 11.7 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 6.6 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.3 6.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 4.8 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 4.5 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 4.1 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 3.4 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 3.1 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.9 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 2.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.9 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 2.8 REACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 2.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.1 2.5 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 2.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 2.3 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.1 2.1 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 2.0 REACTOME_PLATELET_AGGREGATION_PLUG_FORMATION Genes involved in Platelet Aggregation (Plug Formation)
0.1 1.8 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin