Motif ID: AAGGUGC

Z-value: 0.270


Mature miRNA associated with seed AAGGUGC:

NamemiRBase Accession
hsa-miR-18a-5p MIMAT0000072
hsa-miR-18b-5p MIMAT0001412
hsa-miR-4735-3p MIMAT0019861



Activity profile for motif AAGGUGC.

activity profile for motif AAGGUGC


Sorted Z-values histogram for motif AAGGUGC

Sorted Z-values for motif AAGGUGC



Network of associatons between targets according to the STRING database.



First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:


Showing 1 to 20 of 127 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_132272504 0.795 ENST00000367976.3
 CTGF
connective tissue growth factor
chr4_+_55524085 0.549 ENST00000412167.2
ENST00000288135.5
 KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

chr6_+_112408768 0.437 ENST00000368656.2
ENST00000604268.1
 FAM229B

family with sequence similarity 229, member B

chr12_+_104458235 0.406 ENST00000229330.4
 HCFC2
host cell factor C2
chr9_-_35563896 0.355 ENST00000399742.2
 FAM166B
family with sequence similarity 166, member B
chr6_+_39760783 0.317 ENST00000398904.2
ENST00000538976.1
 DAAM2

dishevelled associated activator of morphogenesis 2

chr15_-_61521495 0.299 ENST00000335670.6
 RORA
RAR-related orphan receptor A
chr3_-_114790179 0.291 ENST00000462705.1
 ZBTB20
zinc finger and BTB domain containing 20
chr12_+_12764773 0.276 ENST00000228865.2
 CREBL2
cAMP responsive element binding protein-like 2
chr11_-_108464321 0.235 ENST00000265843.4
 EXPH5
exophilin 5
chr9_-_74383799 0.234 ENST00000377044.4
 TMEM2
transmembrane protein 2
chr3_-_123603137 0.231 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
 MYLK



myosin light chain kinase



chr16_+_69599861 0.194 ENST00000354436.2
 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr13_-_77601282 0.158 ENST00000355619.5
 FBXL3
F-box and leucine-rich repeat protein 3
chr11_+_108093839 0.154 ENST00000452508.2
 ATM
ataxia telangiectasia mutated
chr5_+_56111361 0.141 ENST00000399503.3
 MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chrX_+_150565653 0.139 ENST00000330374.6
 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr1_+_87794150 0.138 ENST00000370544.5
 LMO4
LIM domain only 4
chr2_+_12857015 0.134 ENST00000155926.4
 TRIB2
tribbles pseudokinase 2
chr12_+_69864129 0.132 ENST00000547219.1
ENST00000299293.2
ENST00000549921.1
ENST00000550316.1
ENST00000548154.1
ENST00000547414.1
ENST00000550389.1
ENST00000550937.1
ENST00000549092.1
ENST00000550169.1
 FRS2









fibroblast growth factor receptor substrate 2










Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 0.8 GO:0034059 response to anoxia(GO:0034059)
0.2 0.5 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.0 0.3 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.2 GO:0072425 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.0 0.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.2 GO:0021527 spinal cord association neuron differentiation(GO:0021527)
0.0 0.1 GO:0045925 positive regulation of female receptivity(GO:0045925)
0.0 0.1 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.1 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.1 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0007296 vitellogenesis(GO:0007296)
0.0 0.1 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.6 GO:0042629 mast cell granule(GO:0042629)
0.1 0.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.1 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.0 GO:0005873 plus-end kinesin complex(GO:0005873)

Gene overrepresentation in molecular_function category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.3 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.2 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.2 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0090541 MIT domain binding(GO:0090541)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.1 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_AMB2_NEUTROPHILS_PATHWAY amb2 Integrin signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.3 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway