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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SP4_PML
Z-value: 2.58
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Transcription factors associated with SP4_PML
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP4 | hg19_v2_chr7_+_21467642_21467671 | -0.36 | 4.8e-01 | Click! |
| PML | hg19_v2_chr15_+_74287035_74287117 | -0.36 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_74212073 Show fit | 8.80 |
ENST00000441217.1
|
AC073046.25 |
|
| chr18_+_20715416 Show fit | 5.09 |
ENST00000580153.1
|
Cdk5 and Abl enzyme substrate 1 |
|
| chr8_-_141645645 Show fit | 4.46 |
ENST00000519980.1
ENST00000220592.5 |
argonaute RISC catalytic component 2 |
|
| chr16_+_84002234 Show fit | 4.11 |
ENST00000305202.4
|
N-terminal EF-hand calcium binding protein 2 |
|
| chr12_+_104235229 Show fit | 3.64 |
ENST00000551650.1
|
Uncharacterized protein |
|
| chr8_+_61592073 Show fit | 3.57 |
ENST00000526846.1
|
chromodomain helicase DNA binding protein 7 |
|
| chr2_-_240322685 Show fit | 3.54 |
ENST00000544989.1
|
histone deacetylase 4 |
|
| chr8_-_42752418 Show fit | 3.38 |
ENST00000524954.1
|
ring finger protein 170 |
|
| chr7_+_97910962 Show fit | 3.37 |
ENST00000539286.1
|
brain protein I3 |
|
| chr8_-_1922789 Show fit | 3.30 |
ENST00000521498.1
|
RP11-439C15.4 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP4_PML
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 6.3 | GO:0090625 | mRNA cleavage involved in gene silencing by siRNA(GO:0090625) |
| 0.1 | 6.0 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 0.2 | 5.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.4 | 5.5 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
| 0.2 | 5.4 | GO:0097264 | self proteolysis(GO:0097264) |
| 1.3 | 5.3 | GO:1904020 | regulation of G-protein coupled receptor internalization(GO:1904020) |
| 0.2 | 5.1 | GO:0046339 | diacylglycerol metabolic process(GO:0046339) |
| 0.2 | 4.9 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 1.6 | 4.8 | GO:1903697 | negative regulation of microvillus assembly(GO:1903697) |
| 0.5 | 4.8 | GO:0010748 | regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.9 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 15.0 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 14.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 9.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 9.2 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 7.9 | GO:0001726 | ruffle(GO:0001726) |
| 0.5 | 7.6 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.1 | 7.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.2 | 7.5 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.1 | 7.2 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.4 | GO:0001159 | core promoter proximal region DNA binding(GO:0001159) |
| 0.1 | 14.6 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 8.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.2 | 7.0 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.3 | 6.9 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.2 | 6.8 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 6.6 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.1 | 6.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 6.3 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 6.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.3 | 12.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 11.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 11.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 10.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.2 | 10.0 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 9.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 8.1 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 6.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 6.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 9.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 9.6 | REACTOME CA DEPENDENT EVENTS | Genes involved in Ca-dependent events |
| 0.1 | 8.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 7.0 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 6.9 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 6.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.1 | 6.5 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.1 | 6.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 6.3 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |