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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for REST

Z-value: 0.47

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
ENSG00000084093.11 REST

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.928.9e-03Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr14_+_93389425 0.46 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr10_+_99609996 0.38 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr2_-_27531313 0.37 ENST00000296099.2
UCN
urocortin
chr22_+_31199037 0.35 ENST00000424224.1
OSBP2
oxysterol binding protein 2
chrX_-_49056635 0.31 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr15_-_32162833 0.28 ENST00000560598.1
OTUD7A
OTU domain containing 7A
chr3_+_193853927 0.27 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr16_+_3019309 0.23 ENST00000576565.1
PAQR4
progestin and adipoQ receptor family member IV
chr7_+_150748288 0.20 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr11_-_75141206 0.20 ENST00000376292.4
KLHL35
kelch-like family member 35
chrX_-_153141302 0.19 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
L1CAM
L1 cell adhesion molecule
chr19_-_11639910 0.18 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr16_+_3019246 0.18 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr11_-_72492878 0.18 ENST00000535054.1
ENST00000545082.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr12_-_24737089 0.17 ENST00000483544.1
LINC00477
long intergenic non-protein coding RNA 477
chr3_-_48700310 0.16 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chr17_+_72667239 0.16 ENST00000402449.4
RAB37
RAB37, member RAS oncogene family
chr20_-_62284766 0.15 ENST00000370053.1
STMN3
stathmin-like 3
chrX_+_153238220 0.15 ENST00000425274.1
TMEM187
transmembrane protein 187
chr11_+_64808675 0.14 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr19_-_11639931 0.14 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr17_+_30813576 0.14 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_-_3971050 0.14 ENST00000545797.2
ENST00000596311.1
DAPK3
death-associated protein kinase 3
chr19_+_39759154 0.13 ENST00000331982.5
IFNL2
interferon, lambda 2
chr7_-_65113280 0.13 ENST00000593865.1
AC104057.1
Protein LOC100996407
chr10_+_102790980 0.12 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3
chrX_-_153141434 0.12 ENST00000407935.2
ENST00000439496.1
L1CAM
L1 cell adhesion molecule
chrX_-_153237258 0.12 ENST00000310441.7
HCFC1
host cell factor C1 (VP16-accessory protein)
chr12_+_52695617 0.12 ENST00000293525.5
KRT86
keratin 86
chr16_+_335680 0.11 ENST00000435833.1
PDIA2
protein disulfide isomerase family A, member 2
chr5_+_175298487 0.11 ENST00000393745.3
CPLX2
complexin 2
chr8_-_145752390 0.11 ENST00000529415.2
ENST00000533758.1
LRRC24
leucine rich repeat containing 24
chr19_-_45927622 0.10 ENST00000300853.3
ENST00000589165.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr14_-_51562037 0.10 ENST00000338969.5
TRIM9
tripartite motif containing 9
chr5_+_175298674 0.10 ENST00000514150.1
CPLX2
complexin 2
chr19_+_9203855 0.10 ENST00000429566.3
OR1M1
olfactory receptor, family 1, subfamily M, member 1
chr20_+_36012051 0.10 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr5_-_176037105 0.10 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr1_+_171750776 0.09 ENST00000458517.1
ENST00000362019.3
ENST00000367737.5
ENST00000361735.3
METTL13
methyltransferase like 13
chr15_+_75287861 0.09 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
SCAMP5
secretory carrier membrane protein 5
chr11_+_45907177 0.09 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chr5_+_175298573 0.08 ENST00000512824.1
CPLX2
complexin 2
chr10_+_60936921 0.08 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr1_-_40105617 0.08 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr6_+_43603552 0.07 ENST00000372171.4
MAD2L1BP
MAD2L1 binding protein
chr5_-_135701164 0.07 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr4_+_96012585 0.07 ENST00000502683.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr1_+_154540246 0.07 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr12_+_113796347 0.07 ENST00000545182.2
ENST00000280800.3
PLBD2
phospholipase B domain containing 2
chr1_+_212606219 0.07 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr18_-_40857493 0.07 ENST00000255224.3
SYT4
synaptotagmin IV
chr3_-_8686479 0.07 ENST00000544814.1
ENST00000427408.1
SSUH2
ssu-2 homolog (C. elegans)
chr11_-_66115032 0.07 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr3_+_9745487 0.06 ENST00000383832.3
CPNE9
copine family member IX
chr2_+_46524537 0.06 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr19_-_45927097 0.06 ENST00000340192.7
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr2_+_226265364 0.05 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr19_-_40724246 0.05 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr12_+_113229337 0.05 ENST00000552667.1
RPH3A
rabphilin 3A homolog (mouse)
chr12_+_113229737 0.05 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr17_-_7218403 0.05 ENST00000570780.1
GPS2
G protein pathway suppressor 2
chr20_+_30555805 0.05 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr5_+_167956121 0.05 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr12_+_113229725 0.04 ENST00000551198.1
RPH3A
rabphilin 3A homolog (mouse)
chr12_-_12837423 0.04 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr10_-_79398127 0.04 ENST00000372443.1
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr6_+_25652501 0.04 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr12_+_113229708 0.04 ENST00000550901.1
RPH3A
rabphilin 3A homolog (mouse)
chr19_-_45926739 0.04 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr15_-_72612470 0.03 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr20_+_62327996 0.03 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr19_-_51845378 0.03 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr19_-_55691614 0.03 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr12_-_99288986 0.03 ENST00000552407.1
ENST00000551613.1
ENST00000548447.1
ENST00000546364.3
ENST00000552748.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr8_-_91095099 0.02 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr3_-_131753830 0.02 ENST00000429747.1
CPNE4
copine IV
chr20_+_44657807 0.02 ENST00000372315.1
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr12_+_113229452 0.02 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chrX_-_47479246 0.02 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr18_-_40857447 0.01 ENST00000590752.1
ENST00000596867.1
SYT4
synaptotagmin IV
chr10_+_89419370 0.01 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr3_+_9745510 0.01 ENST00000383831.3
CPNE9
copine family member IX
chr6_+_25652432 0.01 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr14_-_74892805 0.00 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr2_-_51259641 0.00 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr12_-_57443886 0.00 ENST00000300119.3
MYO1A
myosin IA
chr10_-_79398250 0.00 ENST00000286627.5
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr6_+_158957431 0.00 ENST00000367090.3
TMEM181
transmembrane protein 181
chr14_-_51561784 0.00 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr2_+_131513864 0.00 ENST00000458606.1
ENST00000423981.1
AMER3
APC membrane recruitment protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1900738 dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.1 0.4 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 0.3 GO:0060164 negative regulation of auditory receptor cell differentiation(GO:0045608) negative regulation of mechanoreceptor differentiation(GO:0045632) regulation of timing of neuron differentiation(GO:0060164) negative regulation of inner ear receptor cell differentiation(GO:2000981)
0.0 0.1 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.0 0.2 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.0 0.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.2 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.0 0.1 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.2 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.0 0.1 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.0 GO:0000494 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.0 0.2 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.2 GO:0032782 bile acid secretion(GO:0032782)
0.0 0.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 0.3 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 GO:0043196 varicosity(GO:0043196)
0.0 0.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.3 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.5 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.4 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.0 0.2 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.2 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.1 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.0 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)