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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for HOXD1

Z-value: 0.37

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
ENSG00000128645.11 HOXD1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg19_v2_chr2_+_177053307_1770534020.295.8e-01Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_+_67535647 0.34 ENST00000520675.1
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr4_-_19458597 0.26 ENST00000505347.1
RP11-3J1.1
RP11-3J1.1
chr22_-_28490123 0.26 ENST00000442232.1
TTC28
tetratricopeptide repeat domain 28
chr7_-_99716914 0.25 ENST00000431404.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr3_-_191000172 0.20 ENST00000427544.2
UTS2B
urotensin 2B
chr7_+_37723450 0.17 ENST00000447769.1
GPR141
G protein-coupled receptor 141
chr11_+_71900703 0.16 ENST00000393681.2
FOLR1
folate receptor 1 (adult)
chr11_+_71900572 0.14 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr4_+_71019903 0.14 ENST00000344526.5
C4orf40
chromosome 4 open reading frame 40
chr12_-_52761262 0.13 ENST00000257901.3
KRT85
keratin 85
chr20_-_50418947 0.13 ENST00000371539.3
SALL4
spalt-like transcription factor 4
chr22_-_24951888 0.13 ENST00000404664.3
GUCD1
guanylyl cyclase domain containing 1
chr17_-_57229155 0.12 ENST00000584089.1
SKA2
spindle and kinetochore associated complex subunit 2
chr3_-_126327398 0.11 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr2_+_228736335 0.11 ENST00000440997.1
ENST00000545118.1
DAW1
dynein assembly factor with WDR repeat domains 1
chrX_+_107288239 0.11 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_71823796 0.11 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr5_+_148737562 0.10 ENST00000274569.4
PCYOX1L
prenylcysteine oxidase 1 like
chr15_-_55562479 0.10 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr12_+_64798826 0.10 ENST00000540203.1
XPOT
exportin, tRNA
chr4_+_144354644 0.10 ENST00000512843.1
GAB1
GRB2-associated binding protein 1
chr11_-_71823715 0.10 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr2_+_191221240 0.10 ENST00000409027.1
ENST00000458193.1
INPP1
inositol polyphosphate-1-phosphatase
chr7_-_55620433 0.09 ENST00000418904.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr7_+_99717230 0.09 ENST00000262932.3
CNPY4
canopy FGF signaling regulator 4
chrX_+_107288197 0.09 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr15_+_63050785 0.09 ENST00000472902.1
TLN2
talin 2
chr7_-_99717463 0.09 ENST00000437822.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr22_-_24951814 0.09 ENST00000407973.2
GUCD1
guanylyl cyclase domain containing 1
chr1_-_232651312 0.08 ENST00000262861.4
SIPA1L2
signal-induced proliferation-associated 1 like 2
chr2_+_135596180 0.08 ENST00000283054.4
ENST00000392928.1
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr7_-_99716940 0.08 ENST00000440225.1
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr7_-_99716952 0.08 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chrX_-_19504642 0.08 ENST00000469203.2
MAP3K15
mitogen-activated protein kinase kinase kinase 15
chr4_-_119759795 0.07 ENST00000419654.2
SEC24D
SEC24 family member D
chr19_-_3557570 0.07 ENST00000355415.2
MFSD12
major facilitator superfamily domain containing 12
chr12_+_15699286 0.07 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr12_-_118797475 0.07 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr5_+_66300464 0.06 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr9_+_124329336 0.06 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2IP
DAB2 interacting protein
chr11_-_71823266 0.06 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr10_+_99205894 0.06 ENST00000370854.3
ENST00000393760.1
ENST00000414567.1
ENST00000370846.4
ZDHHC16
zinc finger, DHHC-type containing 16
chr11_+_73498898 0.06 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr20_+_43990576 0.06 ENST00000372727.1
ENST00000414310.1
SYS1
SYS1 Golgi-localized integral membrane protein homolog (S. cerevisiae)
chr15_+_58702742 0.06 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr1_+_117544366 0.06 ENST00000256652.4
ENST00000369470.1
CD101
CD101 molecule
chr20_-_50419055 0.06 ENST00000217086.4
SALL4
spalt-like transcription factor 4
chr14_+_32798462 0.05 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr1_-_151431674 0.05 ENST00000531094.1
POGZ
pogo transposable element with ZNF domain
chr10_-_72142345 0.05 ENST00000373224.1
ENST00000446961.1
ENST00000358141.2
ENST00000357631.2
LRRC20
leucine rich repeat containing 20
chr10_+_99205959 0.05 ENST00000352634.4
ENST00000353979.3
ENST00000370842.2
ENST00000345745.5
ZDHHC16
zinc finger, DHHC-type containing 16
chr10_+_18549645 0.05 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr14_+_32798547 0.05 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chrX_+_43515467 0.05 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr1_-_151431647 0.05 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr5_+_66300446 0.04 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_+_18086392 0.04 ENST00000541285.1
ALKBH5
alkB, alkylation repair homolog 5 (E. coli)
chr19_-_36001113 0.04 ENST00000434389.1
DMKN
dermokine
chr11_-_26593649 0.04 ENST00000455601.2
MUC15
mucin 15, cell surface associated
chr12_+_29376592 0.04 ENST00000182377.4
FAR2
fatty acyl CoA reductase 2
chr1_-_151431909 0.04 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr4_-_150736962 0.04 ENST00000502345.1
ENST00000510975.1
ENST00000511993.1
RP11-526A4.1
RP11-526A4.1
chr12_+_29376673 0.03 ENST00000547116.1
FAR2
fatty acyl CoA reductase 2
chr2_+_135596106 0.03 ENST00000356140.5
ACMSD
aminocarboxymuconate semialdehyde decarboxylase
chr4_-_74486347 0.03 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr1_-_92952433 0.03 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr15_-_55562582 0.03 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr12_+_109577202 0.03 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr14_+_56584414 0.02 ENST00000559044.1
PELI2
pellino E3 ubiquitin protein ligase family member 2
chr15_-_37393406 0.01 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chrX_+_77154935 0.01 ENST00000481445.1
COX7B
cytochrome c oxidase subunit VIIb
chr3_-_99569821 0.01 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr13_-_36050819 0.01 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr15_-_55563072 0.01 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr7_-_81399438 0.01 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr4_+_158493642 0.01 ENST00000507108.1
ENST00000455598.1
ENST00000509450.1
RP11-364P22.1
RP11-364P22.1
chr2_-_99871570 0.01 ENST00000333017.2
ENST00000409679.1
ENST00000423306.1
LYG2
lysozyme G-like 2
chr1_-_201140673 0.01 ENST00000367333.2
TMEM9
transmembrane protein 9
chr11_-_102709441 0.01 ENST00000434103.1
MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr17_-_27418537 0.01 ENST00000408971.2
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr8_+_55528627 0.01 ENST00000220676.1
RP1
retinitis pigmentosa 1 (autosomal dominant)
chr16_+_53133070 0.01 ENST00000565832.1
CHD9
chromodomain helicase DNA binding protein 9
chr8_-_49833978 0.01 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr5_+_63802109 0.01 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr5_-_20575959 0.01 ENST00000507958.1
CDH18
cadherin 18, type 2
chr1_-_190446759 0.00 ENST00000367462.3
BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr4_-_139051839 0.00 ENST00000514600.1
ENST00000513895.1
ENST00000512536.1
LINC00616
long intergenic non-protein coding RNA 616

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061713 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713) cellular response to folic acid(GO:0071231)
0.0 0.1 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.0 0.1 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.0 0.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.4 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0010166 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)
0.0 0.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0061714 folic acid receptor activity(GO:0061714)
0.0 0.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829)
0.0 0.1 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.0 0.1 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling