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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SP1
Z-value: 2.68
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Transcription factors associated with SP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP1 | hg19_v2_chr12_+_53773944_53773993 | -0.84 | 3.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_129987488 Show fit | 3.97 |
ENST00000446764.1
|
GTPase activating Rap/RanGAP domain-like 3 |
|
| chr9_+_96717821 Show fit | 3.64 |
ENST00000454594.1
|
RP11-231K24.2 |
|
| chr8_-_99837856 Show fit | 3.53 |
ENST00000518165.1
ENST00000419617.2 |
serine/threonine kinase 3 |
|
| chr13_-_52027134 Show fit | 3.34 |
ENST00000311234.4
ENST00000425000.1 ENST00000463928.1 ENST00000442263.3 ENST00000398119.2 |
integrator complex subunit 6 |
|
| chr21_+_42792442 Show fit | 2.92 |
ENST00000398600.2
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr17_-_7197881 Show fit | 2.85 |
ENST00000007699.5
|
Y box binding protein 2 |
|
| chr17_+_41177220 Show fit | 2.84 |
ENST00000587250.2
ENST00000544533.1 |
Rho family GTPase 2 |
|
| chr17_-_53499310 Show fit | 2.64 |
ENST00000262065.3
|
monocyte to macrophage differentiation-associated |
|
| chr19_+_55795493 Show fit | 2.62 |
ENST00000309383.1
|
BR serine/threonine kinase 1 |
|
| chr19_-_39832563 Show fit | 2.50 |
ENST00000599274.1
|
CTC-246B18.10 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.7 | GO:0035735 | intraciliary transport involved in cilium morphogenesis(GO:0035735) |
| 0.2 | 6.3 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 6.1 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.1 | 6.0 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.3 | 5.4 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.0 | 5.1 | GO:1990823 | response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830) |
| 0.1 | 4.7 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 0.5 | 4.6 | GO:0046940 | nucleoside monophosphate phosphorylation(GO:0046940) |
| 0.2 | 4.5 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 0.1 | 4.5 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.3 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.3 | 8.5 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.7 | 7.4 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.3 | 6.6 | GO:0097227 | sperm annulus(GO:0097227) |
| 0.1 | 6.2 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 6.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 6.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 5.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 4.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 4.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.6 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.1 | 9.4 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 8.2 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 7.9 | GO:0061659 | ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.2 | 6.7 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.1 | 6.4 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 6.1 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.1 | 5.8 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
| 0.1 | 5.6 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.3 | 5.0 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.8 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.1 | 8.4 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 7.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 5.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 5.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 4.9 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 4.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 4.3 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 4.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.1 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 7.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 7.2 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 6.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 6.2 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 6.2 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.1 | 6.1 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.1 | 5.2 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 5.2 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.3 | 4.3 | REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX | Genes involved in CDC6 association with the ORC:origin complex |