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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for NR5A2
Z-value: 1.08
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Transcription factors associated with NR5A2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR5A2 | hg19_v2_chr1_+_199996702_199996732 | -0.83 | 4.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_27806117 Show fit | 1.01 |
ENST00000330180.2
|
histone cluster 1, H2ak |
|
| chr21_+_33671264 Show fit | 0.98 |
ENST00000339944.4
|
melanocortin 2 receptor accessory protein |
|
| chr6_-_26235206 Show fit | 0.93 |
ENST00000244534.5
|
histone cluster 1, H1d |
|
| chr16_-_67224002 Show fit | 0.85 |
ENST00000563889.1
ENST00000564418.1 ENST00000545725.2 ENST00000314586.6 |
exocyst complex component 3-like 1 |
|
| chr17_-_67323385 Show fit | 0.75 |
ENST00000588665.1
|
ATP-binding cassette, sub-family A (ABC1), member 5 |
|
| chr19_+_2249308 Show fit | 0.65 |
ENST00000592877.1
ENST00000221496.4 |
anti-Mullerian hormone |
|
| chr4_-_185776854 Show fit | 0.63 |
ENST00000511703.1
|
RP11-701P16.5 |
|
| chr8_+_94752349 Show fit | 0.61 |
ENST00000391680.1
|
RBM12B antisense RNA 1 |
|
| chr17_-_73844722 Show fit | 0.56 |
ENST00000586257.1
|
WW domain binding protein 2 |
|
| chr4_-_170948361 Show fit | 0.54 |
ENST00000393702.3
|
microfibrillar-associated protein 3-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR5A2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.0 | 0.9 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.0 | 0.8 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.2 | 0.6 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
| 0.1 | 0.6 | GO:0071442 | positive regulation of histone H3-K14 acetylation(GO:0071442) |
| 0.0 | 0.6 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.0 | 0.6 | GO:0097067 | cellular response to thyroid hormone stimulus(GO:0097067) |
| 0.0 | 0.6 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.2 | 0.5 | GO:0015729 | thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356) |
| 0.1 | 0.5 | GO:0006218 | uridine catabolic process(GO:0006218) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.8 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.5 | GO:1990130 | Iml1 complex(GO:1990130) |
| 0.0 | 0.5 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.0 | 0.5 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 0.4 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 0.4 | GO:0031105 | septin complex(GO:0031105) |
| 0.1 | 0.3 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.0 | 0.3 | GO:1990635 | proximal dendrite(GO:1990635) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.0 | 1.0 | GO:0043621 | protein self-association(GO:0043621) |
| 0.3 | 0.9 | GO:0031783 | corticotropin hormone receptor binding(GO:0031780) type 5 melanocortin receptor binding(GO:0031783) |
| 0.0 | 0.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 0.5 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.2 | 0.5 | GO:0015117 | thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131) |
| 0.1 | 0.5 | GO:0004850 | uridine phosphorylase activity(GO:0004850) |
| 0.1 | 0.5 | GO:0015181 | arginine transmembrane transporter activity(GO:0015181) |
| 0.0 | 0.5 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.0 | 0.5 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 0.7 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 0.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.2 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.2 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 0.1 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.1 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 1.0 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.9 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.7 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 0.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.6 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.0 | 0.5 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |