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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for MXI1_MYC_MYCN
Z-value: 2.64
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Transcription factors associated with MXI1_MYC_MYCN
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000119950.16 | MAX interactor 1, dimerization protein | |
| ENSG00000136997.10 | MYC proto-oncogene, bHLH transcription factor | |
| ENSG00000134323.10 | MYCN proto-oncogene, bHLH transcription factor |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MXI1 | hg19_v2_chr10_+_111985713_111985774 | -0.83 | 4.2e-02 | Click! |
| MYC | hg19_v2_chr8_+_128747661_128747703 | 0.62 | 1.9e-01 | Click! |
| MYCN | hg19_v2_chr2_+_16080659_16080686 | -0.43 | 4.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_58145889 Show fit | 9.36 |
ENST00000547853.1
|
cyclin-dependent kinase 4 |
|
| chr2_+_74212073 Show fit | 4.41 |
ENST00000441217.1
|
AC073046.25 |
|
| chr18_+_20715416 Show fit | 2.81 |
ENST00000580153.1
|
Cdk5 and Abl enzyme substrate 1 |
|
| chr3_-_126076264 Show fit | 2.45 |
ENST00000296233.3
|
Kruppel-like factor 15 |
|
| chr2_-_232328867 Show fit | 2.39 |
ENST00000453992.1
ENST00000417652.1 ENST00000454824.1 |
nucleolin |
|
| chr2_+_232575168 Show fit | 1.92 |
ENST00000440384.1
|
prothymosin, alpha |
|
| chr16_+_2570340 Show fit | 1.87 |
ENST00000568263.1
ENST00000293971.6 ENST00000302956.4 ENST00000413459.3 ENST00000566706.1 ENST00000569879.1 |
amidohydrolase domain containing 2 |
|
| chr19_-_5720248 Show fit | 1.70 |
ENST00000360614.3
|
lon peptidase 1, mitochondrial |
|
| chr1_+_110162448 Show fit | 1.69 |
ENST00000342115.4
ENST00000469039.2 ENST00000474459.1 ENST00000528667.1 |
adenosine monophosphate deaminase 2 |
|
| chr19_+_54135310 Show fit | 1.68 |
ENST00000376650.1
|
divergent-paired related homeobox |
Network of associatons between targets according to the STRING database.
First level regulatory network of MXI1_MYC_MYCN
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 11.8 | GO:1904636 | response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637) |
| 0.5 | 4.2 | GO:0019262 | N-acetylneuraminate catabolic process(GO:0019262) |
| 0.4 | 4.2 | GO:0019264 | glycine biosynthetic process from serine(GO:0019264) |
| 0.4 | 3.9 | GO:0072592 | oxygen metabolic process(GO:0072592) |
| 0.0 | 3.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.2 | 3.5 | GO:0070407 | oxidation-dependent protein catabolic process(GO:0070407) |
| 0.2 | 3.0 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
| 0.0 | 2.8 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.0 | 2.8 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.1 | 2.7 | GO:0000338 | protein deneddylation(GO:0000338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 11.8 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.1 | 8.0 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.4 | 4.9 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 4.5 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 4.0 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.1 | 3.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.0 | 3.7 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 3.6 | GO:0034709 | methylosome(GO:0034709) |
| 0.3 | 3.0 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 2.7 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 5.5 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.4 | 4.2 | GO:0004793 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
| 0.1 | 4.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.2 | 4.0 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.6 | 3.9 | GO:0004473 | malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
| 0.0 | 3.9 | GO:0005507 | copper ion binding(GO:0005507) |
| 1.2 | 3.5 | GO:0070364 | mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364) |
| 0.1 | 3.2 | GO:0008187 | poly-pyrimidine tract binding(GO:0008187) |
| 0.1 | 3.1 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.7 | 11.7 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 5.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 4.5 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 2.5 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 2.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 2.1 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 2.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 1.8 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.8 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 5.3 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.1 | 4.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 4.0 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.1 | 4.0 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.1 | 3.1 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 3.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 2.7 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.0 | 2.7 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.1 | 2.6 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |