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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for IRF6_IRF4_IRF5
Z-value: 6.08
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Transcription factors associated with IRF6_IRF4_IRF5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| IRF5 | hg19_v2_chr7_+_128577972_128578047 | -0.68 | 1.4e-01 | Click! |
| IRF6 | hg19_v2_chr1_-_209979465_209979494 | -0.21 | 6.9e-01 | Click! |
| IRF4 | hg19_v2_chr6_+_391739_391759 | 0.13 | 8.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_615942 Show fit | 44.69 |
ENST00000397562.3
ENST00000330243.5 ENST00000397570.1 ENST00000397574.2 |
interferon regulatory factor 7 |
|
| chr21_+_42798094 Show fit | 28.19 |
ENST00000398598.3
ENST00000455164.2 ENST00000424365.1 |
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr21_+_42792442 Show fit | 27.91 |
ENST00000398600.2
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr9_-_32526184 Show fit | 24.40 |
ENST00000545044.1
ENST00000379868.1 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
|
| chr9_-_32526299 Show fit | 23.54 |
ENST00000379882.1
ENST00000379883.2 |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
|
| chr1_+_948803 Show fit | 19.99 |
ENST00000379389.4
|
ISG15 ubiquitin-like modifier |
|
| chr21_+_42798124 Show fit | 17.97 |
ENST00000417963.1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr21_+_42798158 Show fit | 17.92 |
ENST00000441677.1
|
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) |
|
| chr11_-_615570 Show fit | 16.74 |
ENST00000525445.1
ENST00000348655.6 ENST00000397566.1 |
interferon regulatory factor 7 |
|
| chr12_+_113344755 Show fit | 15.63 |
ENST00000550883.1
|
2'-5'-oligoadenylate synthetase 1, 40/46kDa |
Network of associatons between targets according to the STRING database.
First level regulatory network of IRF6_IRF4_IRF5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 104.8 | GO:0003374 | dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374) |
| 6.4 | 63.7 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373) |
| 20.5 | 61.4 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 13.1 | 52.5 | GO:0034344 | type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344) |
| 0.5 | 41.3 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 3.7 | 40.6 | GO:0070212 | protein poly-ADP-ribosylation(GO:0070212) |
| 1.2 | 36.5 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 2.4 | 29.1 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 1.4 | 16.4 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.3 | 15.7 | GO:0010390 | histone monoubiquitination(GO:0010390) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 112.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 70.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 69.6 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 64.6 | GO:0045121 | membrane raft(GO:0045121) |
| 0.3 | 56.3 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 47.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.0 | 9.0 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 8.8 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.2 | 3.7 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.1 | 2.7 | GO:0016580 | Sin3 complex(GO:0016580) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 104.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.5 | 67.4 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 3.0 | 63.7 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.4 | 61.6 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 5.1 | 61.0 | GO:0001730 | 2'-5'-oligoadenylate synthetase activity(GO:0001730) |
| 1.3 | 39.9 | GO:0070403 | NAD+ binding(GO:0070403) |
| 1.2 | 15.7 | GO:0031386 | protein tag(GO:0031386) |
| 0.0 | 13.7 | GO:0042393 | histone binding(GO:0042393) |
| 1.7 | 10.5 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.9 | 9.1 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 63.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 12.8 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.9 | 11.5 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 8.1 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.1 | 3.5 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 2.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 2.7 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.1 | 2.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.0 | 2.1 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 223.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 5.6 | 116.9 | REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY | Genes involved in TRAF3-dependent IRF activation pathway |
| 0.0 | 11.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 10.5 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 9.6 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.2 | 6.6 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.0 | 5.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 2.7 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 2.5 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |
| 0.1 | 2.1 | REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Acetylcholine Neurotransmitter Release Cycle |