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A549 cells infected with SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ESRRA_ESR2
Z-value: 2.60
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Transcription factors associated with ESRRA_ESR2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ESRRA | hg19_v2_chr11_+_64073699_64073918 | 0.94 | 5.6e-03 | Click! |
| ESR2 | hg19_v2_chr14_-_64804814_64804842 | 0.68 | 1.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_12679171 Show fit | 2.79 |
ENST00000606790.1
|
RP11-474O21.5 |
|
| chr11_-_45928830 Show fit | 2.26 |
ENST00000449465.1
|
chromosome 11 open reading frame 94 |
|
| chr21_-_46492927 Show fit | 1.76 |
ENST00000599569.1
|
Uncharacterized protein |
|
| chr12_-_53207842 Show fit | 1.65 |
ENST00000458244.2
|
keratin 4 |
|
| chr16_+_2880254 Show fit | 1.61 |
ENST00000570670.1
|
zymogen granule protein 16B |
|
| chr10_+_81065975 Show fit | 1.61 |
ENST00000446377.2
|
zinc finger, MIZ-type containing 1 |
|
| chr16_-_69448 Show fit | 1.60 |
ENST00000326592.9
|
WAS protein family homolog 4 pseudogene |
|
| chr16_-_2581409 Show fit | 1.58 |
ENST00000567119.1
ENST00000565480.1 ENST00000382350.1 |
cementum protein 1 |
|
| chr19_+_5914213 Show fit | 1.51 |
ENST00000222125.5
ENST00000452990.2 ENST00000588865.1 |
calcyphosine |
|
| chr17_-_77967433 Show fit | 1.49 |
ENST00000571872.1
|
TBC1 domain family, member 16 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ESRRA_ESR2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.9 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 0.1 | 4.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 3.6 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.1 | 3.3 | GO:0006007 | glucose catabolic process(GO:0006007) |
| 0.1 | 3.2 | GO:0015991 | ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.2 | 3.0 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
| 0.1 | 3.0 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 2.9 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.4 | 2.8 | GO:0061767 | negative regulation of lung blood pressure(GO:0061767) |
| 0.2 | 2.8 | GO:0019388 | galactose catabolic process(GO:0019388) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 6.8 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 6.2 | GO:0042641 | actomyosin(GO:0042641) |
| 0.1 | 5.3 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 4.1 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 3.6 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 3.5 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 3.1 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.2 | 2.7 | GO:0031931 | TORC1 complex(GO:0031931) |
| 0.0 | 2.7 | GO:0002102 | podosome(GO:0002102) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 5.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 4.6 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 4.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 3.8 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.2 | 3.4 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.1 | 3.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.4 | 2.8 | GO:0031962 | mineralocorticoid receptor binding(GO:0031962) |
| 0.0 | 2.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.3 | 2.6 | GO:0005280 | hydrogen:amino acid symporter activity(GO:0005280) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 4.6 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 4.3 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 3.7 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.1 | 3.2 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.0 | 3.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 3.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 2.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 2.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 0.1 | 5.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 5.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 4.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.1 | 3.9 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.3 | 3.1 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 3.1 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 3.0 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 2.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.1 | 2.9 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |