YNL301C	23.6731	SWI6	YNL301C|RPL18B|S000005245|Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YPL256C	20.2282	SWI6	YPL256C|CLN2|S000006177|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YDL055C	19.4031	SWI6	YDL055C|PSA1|S000002213|GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YNL289W	19.0601	SWI6	YNL289W|PCL1|S000005233|Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YNL300W	18.2074	SWI6	YNL300W||S000005244|Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YER070W	16.2773	SWI6	YER070W|RNR1|S000000872|One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YJL158C	15.5084	SWI6	YJL158C|CIS3|S000003694|Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YGR108W	15.383	SWI6	YGR108W|CLB1|S000003340|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGL179C	14.9009	SWI6	YGL179C|TOS3|S000003147|Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YKL096W-A	14.6913	SWI6	YKL096W-A|CWP2|S000001956|Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YIR021W	13.9712	SWI6	YIR021W|MRS1|S000001460|Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YKR092C	12.9247	SWI6	YKR092C|SRP40|S000001800|Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YFR055W	12.5915	SWI6	YFR055W|IRC7|S000001952|Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YDR509W	11.4806	SWI6	YDR509W||S000002917|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR508C	11.2908	SWI6	YDR508C|GNP1|S000002916|High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YPR119W	11.1906	SWI6	YPR119W|CLB2|S000006323|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YOR226C	11.0916	SWI6	YOR226C|ISU2|S000005752|Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YFR056C	10.949	SWI6	YFR056C||S000001951|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YKR013W	10.2884	SWI6	YKR013W|PRY2|S000001721|Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YMR199W	10.1053	SWI6	YMR199W|CLN1|S000004812|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGR148C	9.6063	SWI6	YGR148C|RPL24B|S000003380|Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YDR044W	9.57886	SWI6	YDR044W|HEM13|S000002451|Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YGL147C	8.5996	SWI6	YGL147C|RPL9A|S000003115|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YPL163C	8.59414	SWI6	YPL163C|SVS1|S000006084|Cell wall and vacuolar protein, required for wild-type resistance to vanadate
YCL063W	8.41161	SWI6	YCL063W|VAC17|S000000568|Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YFL045C	8.39724	SWI6	YFL045C|SEC53|S000001849|Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YKR012C	8.34628	SWI6	YKR012C||S000001720|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YGL225W	8.15144	SWI6	YGL225W|VRG4|S000003193|Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YLR183C	8.07864	SWI6	YLR183C|TOS4|S000004173|Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YEL053W-A	7.99056	SWI6	YEL053W-A||S000028744|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YEL040W	7.80245	SWI6	YEL040W|UTR2|S000000766|Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YLR185W	7.77381	SWI6	YLR185W|RPL37A|S000004175|Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YDL211C	7.72965	SWI6	YDL211C||S000002370|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YOR342C	7.45669	SWI6	YOR342C||S000005869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YMR307W	7.39231	SWI6	YMR307W|GAS1|S000004924|Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YOL101C	7.34658	SWI6	YOL101C|IZH4|S000005461|Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YOL007C	7.22275	SWI6	YOL007C|CSI2|S000005367|Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
YIL069C	7.13621	SWI6	YIL069C|RPS24B|S000001331|Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YER001W	7.0832	SWI6	YER001W|MNN1|S000000803|Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YIL118W	6.9946	SWI6	YIL118W|RHO3|S000001380|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YNL030W	6.81694	SWI6	YNL030W|HHF2|S000004975|One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YGL039W	6.70748	SWI6	YGL039W||S000003007|Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YMR049C	6.64142	SWI6	YMR049C|ERB1|S000004652|Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YLR110C	6.62876	SWI6	YLR110C|CCW12|S000004100|Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YOL015W	6.49887	SWI6	YOL015W|IRC10|S000005375|Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YGL031C	6.44826	SWI6	YGL031C|RPL24A|S000002999|Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YKL218C	6.44006	SWI6	YKL218C|SRY1|S000001701|3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YCL064C	6.27781	SWI6	YCL064C|CHA1|S000000569|Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YKL122C	6.22449	SWI6	YKL122C|SRP21|S000001605|Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YEL001C	6.13269	SWI6	YEL001C|IRC22|S000000727|Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YBR143C	6.09309	SWI6	YBR143C|SUP45|S000000347|Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YGR152C	6.08422	SWI6	YGR152C|RSR1|S000003384|GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YHR141C	5.91827	SWI6	YHR141C|RPL42B|S000001183|Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YLL045C	5.73933	SWI6	YLL045C|RPL8B|S000003968|Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YGL030W	5.68751	SWI6	YGL030W|RPL30|S000002998|Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YOR315W	5.67896	SWI6	YOR315W|SFG1|S000005842|Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YCR034W	5.65656	SWI6	YCR034W|FEN1|S000000630|Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YBR210W	5.60096	SWI6	YBR210W|ERV15|S000000414|Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YBR088C	5.50119	SWI6	YBR088C|POL30|S000000292|Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YDL191W	5.48092	SWI6	YDL191W|RPL35A|S000002350|Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YDR309C	5.47937	SWI6	YDR309C|GIC2|S000002717|Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YGR187C	5.41743	SWI6	YGR187C|HGH1|S000003419|Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YDL003W	5.31101	SWI6	YDL003W|MCD1|S000002161|Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YDR002W	5.24308	SWI6	YDR002W|YRB1|S000002409|Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YDR224C	5.23895	SWI6	YDR224C|HTB1|S000002632|One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YJR094W-A	5.15097	SWI6	YJR094W-A|RPL43B|S000003855|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YKL165C	5.15041	SWI6	YKL165C|MCD4|S000001648|Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YLR154C	5.12903	SWI6	YLR154C|RNH203|S000004144|Ribonuclease H2 subunit, required for RNase H2 activity
YOL016C	4.90583	SWI6	YOL016C|CMK2|S000005376|Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YLR339C	4.89932	SWI6	YLR339C||S000004331|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YCL024W	4.78656	SWI6	YCL024W|KCC4|S000000529|Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YGL201C	4.78312	SWI6	YGL201C|MCM6|S000003169|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YBR162C	4.77802	SWI6	YBR162C|TOS1|S000000366|Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YLR340W	4.7022	SWI6	YLR340W|RPP0|S000004332|Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
YKL110C	4.68106	SWI6	YKL110C|KTI12|S000001593|Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YKR093W	4.66731	SWI6	YKR093W|PTR2|S000001801|Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YJL115W	4.66551	SWI6	YJL115W|ASF1|S000003651|Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YHL033C	4.64613	SWI6	YHL033C|RPL8A|S000001025|Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YDR225W	4.59646	SWI6	YDR225W|HTA1|S000002633|One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YGR214W	4.52414	SWI6	YGR214W|RPS0A|S000003446|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YPL255W	4.52239	SWI6	YPL255W|BBP1|S000006176|Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YCR065W	4.52106	SWI6	YCR065W|HCM1|S000000661|Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
YDL219W	4.4833	SWI6	YDL219W|DTD1|S000002378|D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
YDL192W	4.47382	SWI6	YDL192W|ARF1|S000002351|ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YNL231C	4.43775	SWI6	YNL231C|PDR16|S000005175|Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YGL040C	4.43772	SWI6	YGL040C|HEM2|S000003008|Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YOR247W	4.43604	SWI6	YOR247W|SRL1|S000005773|Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YLR137W	4.41365	SWI6	YLR137W||S000004127|Putative protein of unknown function
YGL097W	4.39887	SWI6	YGL097W|SRM1|S000003065|Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YPR170W-B	4.39128	SWI6	YPR170W-B||S000028515|Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YGR090W	4.37893	SWI6	YGR090W|UTP22|S000003322|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YGR159C	4.35436	SWI6	YGR159C|NSR1|S000003391|Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YJL080C	4.34476	SWI6	YJL080C|SCP160|S000003616|Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YLR154W-A	4.32485	SWI6	YLR154W-A||S000028675|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B	4.28829	SWI6	YLR154W-B||S000028563|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOL039W	4.233	SWI6	YOL039W|RPP2A|S000005399|Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YDL145C	4.23288	SWI6	YDL145C|COP1|S000002304|Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YGR040W	4.22849	SWI6	YGR040W|KSS1|S000003272|Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YPL263C	4.17123	SWI6	YPL263C|KEL3|S000006184|Cytoplasmic protein of unknown function
YOL103W	4.16528	SWI6	YOL103W|ITR2|S000005463|Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YOR222W	4.12114	SWI6	YOR222W|ODC2|S000005748|Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YFL015W-A	4.09514	SWI6	YFL015W-A||S000028765|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR381W	4.06768	SWI6	YDR381W|YRA1|S000002789|Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YIL133C	4.06013	SWI6	YIL133C|RPL16A|S000001395|N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YCL023C	4.05244	SWI6	YCL023C||S000000528|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YIL123W	4.04948	SWI6	YIL123W|SIM1|S000001385|Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YLR186W	4.04313	SWI6	YLR186W|EMG1|S000004176|Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers
YOR376W-A	4.02849	SWI6	YOR376W-A||S000028586|Putative protein of unknown function; identified by fungal homology and RT-PCR
YFL015C	3.99293	SWI6	YFL015C||S000001879|Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YPR157W	3.98727	SWI6	YPR157W||S000006361|Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR189C	3.97862	SWI6	YGR189C|CRH1|S000003421|Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YLR372W	3.90745	SWI6	YLR372W|SUR4|S000004364|Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YDL227C	3.89559	SWI6	YDL227C|HO|S000002386|Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
YLR109W	3.83384	SWI6	YLR109W|AHP1|S000004099|Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YHR181W	3.82029	SWI6	YHR181W|SVP26|S000001224|Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YKL128C	3.78031	SWI6	YKL128C|PMU1|S000001611|Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YER156C	3.76997	SWI6	YER156C||S000000958|Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDR399W	3.75766	SWI6	YDR399W|HPT1|S000002807|Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YOL040C	3.75156	SWI6	YOL040C|RPS15|S000005400|Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YBL085W	3.72341	SWI6	YBL085W|BOI1|S000000181|Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YMR131C	3.72132	SWI6	YMR131C|RRB1|S000004738|Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YFL037W	3.70567	SWI6	YFL037W|TUB2|S000001857|Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
YGR138C	3.63573	SWI6	YGR138C|TPO2|S000003370|Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YNL031C	3.62712	SWI6	YNL031C|HHT2|S000004976|One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YOL005C	3.62121	SWI6	YOL005C|RPB11|S000005365|RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YBL092W	3.61249	SWI6	YBL092W|RPL32|S000000188|Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YPR170W-A	3.60623	SWI6	YPR170W-A||S000028861|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YMR305C	3.6055	SWI6	YMR305C|SCW10|S000004921|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YPL227C	3.57541	SWI6	YPL227C|ALG5|S000006148|UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YDR345C	3.57376	SWI6	YDR345C|HXT3|S000002753|Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDR033W	3.54909	SWI6	YDR033W|MRH1|S000002440|Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YDR098C	3.53039	SWI6	YDR098C|GRX3|S000002505|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YLR180W	3.48911	SWI6	YLR180W|SAM1|S000004170|S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YHR216W	3.47277	SWI6	YHR216W|IMD2|S000001259|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YKL068W-A	3.46911	SWI6	YKL068W-A||S000028524|Putative protein of unknown function; identified by homology to Ashbya gossypii
YFL022C	3.45226	SWI6	YFL022C|FRS2|S000001872|Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YDR037W	3.44057	SWI6	YDR037W|KRS1|S000002444|Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YBL009W	3.42992	SWI6	YBL009W|ALK2|S000000105|Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins
YDR500C	3.413	SWI6	YDR500C|RPL37B|S000002908|Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YCR099C	3.39868	SWI6	YCR099C||S000000696|Putative protein of unknown function
YIL169C	3.35201	SWI6	YIL169C||S000001431|Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YMR083W	3.34904	SWI6	YMR083W|ADH3|S000004688|Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YDL136W	3.34859	SWI6	YDL136W|RPL35B|S000002295|Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
YLR406C	3.34172	SWI6	YLR406C|RPL31B|S000004398|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YDR510W	3.32275	SWI6	YDR510W|SMT3|S000002918|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YER134C	3.31668	SWI6	YER134C||S000000936|Putative protein of unknown function; non-essential gene
YMR144W	3.29342	SWI6	YMR144W||S000004752|Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YBR112C	3.27976	SWI6	YBR112C|CYC8|S000000316|General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YLR388W	3.24937	SWI6	YLR388W|RPS29A|S000004380|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YKL182W	3.22362	SWI6	YKL182W|FAS1|S000001665|Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YBR244W	3.21331	SWI6	YBR244W|GPX2|S000000448|Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YCR018C	3.19226	SWI6	YCR018C|SRD1|S000000611|Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YER136W	3.18849	SWI6	YER136W|GDI1|S000000938|GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YOL049W	3.18452	SWI6	YOL049W|GSH2|S000005409|Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
YOR375C	3.17533	SWI6	YOR375C|GDH1|S000005902|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YGL012W	3.16013	SWI6	YGL012W|ERG4|S000002980|C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YDR382W	3.15913	SWI6	YDR382W|RPP2B|S000002790|Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YJR123W	3.14675	SWI6	YJR123W|RPS5|S000003884|Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YKL212W	3.14114	SWI6	YKL212W|SAC1|S000001695|Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism
YDL014W	3.13185	SWI6	YDL014W|NOP1|S000002172|Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YGL178W	3.12668	SWI6	YGL178W|MPT5|S000003146|Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
YGR106C	3.12161	SWI6	YGR106C|VOA1|S000003338|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YHR149C	3.10904	SWI6	YHR149C|SKG6|S000001192|Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YDR385W	3.06407	SWI6	YDR385W|EFT2|S000002793|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YJL167W	3.03972	SWI6	YJL167W|ERG20|S000003703|Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YPL183C	3.03286	SWI6	YPL183C|RTT10|S000006104|Cytoplasmic protein with a role in regulation of Ty1 transposition
YFR031C-A	3.01386	SWI6	YFR031C-A|RPL2A|S000002104|Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YNL016W	3.01023	SWI6	YNL016W|PUB1|S000004961|Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YMR215W	3.00318	SWI6	YMR215W|GAS3|S000004828|Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YGR251W	2.99414	SWI6	YGR251W||S000003483|Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YBL077W	2.98967	SWI6	YBL077W||S000000173|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YMR108W	2.98465	SWI6	YMR108W|ILV2|S000004714|Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YLR355C	2.97669	SWI6	YLR355C|ILV5|S000004347|Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YCL058C	2.92857	SWI6	YCL058C|FYV5|S000000563|Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YLR042C	2.91868	SWI6	YLR042C||S000004032|Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YIL056W	2.91309	SWI6	YIL056W|VHR1|S000001318|Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YNL066W	2.87822	SWI6	YNL066W|SUN4|S000005010|Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YHR007C	2.8607	SWI6	YHR007C|ERG11|S000001049|Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YBR106W	2.85338	SWI6	YBR106W|PHO88|S000000310|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YLR084C	2.84467	SWI6	YLR084C|RAX2|S000004074|N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p
YAL033W	2.84299	SWI6	YAL033W|POP5|S000000031|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YJR043C	2.82524	SWI6	YJR043C|POL32|S000003804|Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YGR140W	2.8013	SWI6	YGR140W|CBF2|S000003372|Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YGR229C	2.78726	SWI6	YGR229C|SMI1|S000003461|Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YMR303C	2.78108	SWI6	YMR303C|ADH2|S000004918|Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YOR361C	2.77337	SWI6	YOR361C|PRT1|S000005888|Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YPL267W	2.77037	SWI6	YPL267W|ACM1|S000006188|Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
YLR150W	2.75621	SWI6	YLR150W|STM1|S000004140|Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YBL031W	2.75613	SWI6	YBL031W|SHE1|S000000127|Cytoskeletal protein of unknown function; overexpression causes growth arrest
YLR108C	2.74593	SWI6	YLR108C||S000004098|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YIR013C	2.71587	SWI6	YIR013C|GAT4|S000001452|Protein containing GATA family zinc finger motifs
YNL111C	2.71273	SWI6	YNL111C|CYB5|S000005055|Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YDR450W	2.69956	SWI6	YDR450W|RPS18A|S000002858|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YGL123C-A	2.68623	SWI6	YGL123C-A||S000028634|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGL123W	2.68027	SWI6	YGL123W|RPS2|S000003091|Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YCR006C	2.66739	SWI6	YCR006C||S000000599|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR013C	2.65842	SWI6	YHR013C|ARD1|S000001055|Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YER073W	2.59249	SWI6	YER073W|ALD5|S000000875|Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YJL035C	2.58698	SWI6	YJL035C|TAD2|S000003572|Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
YJR143C	2.57101	SWI6	YJR143C|PMT4|S000003904|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals
YBR113W	2.55672	SWI6	YBR113W||S000000317|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YLR325C	2.54331	SWI6	YLR325C|RPL38|S000004317|Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YHL001W	2.54266	SWI6	YHL001W|RPL14B|S000000993|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein
YJR118C	2.54142	SWI6	YJR118C|ILM1|S000003879|Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth
YJL090C	2.54048	SWI6	YJL090C|DPB11|S000003626|Subunit of DNA Polymerase II Epsilon complex; has BRCT domain, required on the prereplicative complex at replication origins for loading DNA polymerases to initiate DNA synthesis, also required for S/M checkpoint control
YAL007C	2.53223	SWI6	YAL007C|ERP2|S000000005|Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YHR180W-A	2.52959	SWI6	YHR180W-A||S000028555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YDL201W	2.52576	SWI6	YDL201W|TRM8|S000002360|Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YJL200C	2.50977	SWI6	YJL200C|ACO2|S000003736|Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YKL042W	2.5072	SWI6	YKL042W|SPC42|S000001525|Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YFR054C	2.50546	SWI6	YFR054C||S000001950|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML088W	2.49166	SWI6	YML088W|UFO1|S000004553|F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YLR411W	2.49035	SWI6	YLR411W|CTR3|S000004403|High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YIL127C	2.4855	SWI6	YIL127C||S000001389|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YOR198C	2.4787	SWI6	YOR198C|BFR1|S000005724|Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
YLR154W-C	2.47229	SWI6	YLR154W-C|TAR1|S000028422|Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YKL096W	2.46871	SWI6	YKL096W|CWP1|S000001579|Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YER086W	2.4529	SWI6	YER086W|ILV1|S000000888|Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YGL038C	2.44525	SWI6	YGL038C|OCH1|S000003006|Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
YHR010W	2.42525	SWI6	YHR010W|RPL27A|S000001052|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YKL127W	2.42106	SWI6	YKL127W|PGM1|S000001610|Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YBR232C	2.41697	SWI6	YBR232C||S000000436|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR170C	2.40858	SWI6	YPR170C||S000006374|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YGL034C	2.40784	SWI6	YGL034C||S000003002|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR139W	2.4059	SWI6	YGR139W||S000003371|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR064W	2.39426	SWI6	YDR064W|RPS13|S000002471|Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
YJL162C	2.38552	SWI6	YJL162C|JJJ2|S000003698|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YMR296C	2.37519	SWI6	YMR296C|LCB1|S000004911|Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YDR072C	2.36843	SWI6	YDR072C|IPT1|S000002479|Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YIR020W-A	2.35144	SWI6	YIR020W-A||S000007241|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOL161C	2.34472	SWI6	YOL161C|PAU20|S000005521|Hypothetical protein
YDL166C	2.34161	SWI6	YDL166C|FAP7|S000002325|Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
YGR036C	2.34055	SWI6	YGR036C|CAX4|S000003268|Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YER159C	2.33554	SWI6	YER159C|BUR6|S000000961|Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YIR033W	2.33093	SWI6	YIR033W|MGA2|S000001472|ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting
YIR020C	2.32928	SWI6	YIR020C||S000001459|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR233W	2.32895	SWI6	YBR233W|PBP2|S000000437|RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
YPR171W	2.32853	SWI6	YPR171W|BSP1|S000006375|Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YGR107W	2.29684	SWI6	YGR107W||S000003339|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR209C	2.29606	SWI6	YMR209C||S000004822|Putative protein of unknown function; YMR209C is not an essential gene
YER137C	2.28135	SWI6	YER137C||S000000939|Putative protein of unknown function
YGL148W	2.27685	SWI6	YGL148W|ARO2|S000003116|Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YKL014C	2.26329	SWI6	YKL014C|URB1|S000001497|Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YNL162W	2.26148	SWI6	YNL162W|RPL42A|S000005106|Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YHR196W	2.26116	SWI6	YHR196W|UTP9|S000001239|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YKL164C	2.25389	SWI6	YKL164C|PIR1|S000001647|O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YOR216C	2.25136	SWI6	YOR216C|RUD3|S000005742|Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1
YLR314C	2.24886	SWI6	YLR314C|CDC3|S000004306|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YOL031C	2.24655	SWI6	YOL031C|SIL1|S000005391|Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YHR127W	2.24461	SWI6	YHR127W||S000001169|Protein of unknown function; localizes to the nucleus
YMR037C	2.24173	SWI6	YMR037C|MSN2|S000004640|Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YDR279W	2.24123	SWI6	YDR279W|RNH202|S000002687|Ribonuclease H2 subunit, required for RNase H2 activity
YJR022W	2.24065	SWI6	YJR022W|LSM8|S000003783|Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
YIL009W	2.21046	SWI6	YIL009W|FAA3|S000001271|Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YBR195C	2.20442	SWI6	YBR195C|MSI1|S000000399|Subunit of chromatin assembly factor I (CAF-1), negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase; localizes to the nucleus and cytoplasm; homologous to human retinoblastoma binding proteins RbAp48 and RbAp46
YLR249W	2.19639	SWI6	YLR249W|YEF3|S000004239|Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YEL055C	2.14217	SWI6	YEL055C|POL5|S000000781|DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
YMR119W	2.12301	SWI6	YMR119W|ASI1|S000004725|Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YBR023C	2.10941	SWI6	YBR023C|CHS3|S000000227|Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YGL027C	2.10569	SWI6	YGL027C|CWH41|S000002995|Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
YCL018W	2.1013	SWI6	YCL018W|LEU2|S000000523|Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YLL002W	2.08443	SWI6	YLL002W|RTT109|S000003925|Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase, acetylates H3-K56; plays a role in regulation of Ty1 transposition
YLR349W	2.08374	SWI6	YLR349W||S000004341|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YDR344C	2.07921	SWI6	YDR344C||S000002752|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL168C	2.07915	SWI6	YJL168C|SET2|S000003704|Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YGL206C	2.07652	SWI6	YGL206C|CHC1|S000003174|Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function
YML021C	2.0732	SWI6	YML021C|UNG1|S000004483|Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus
YDL213C	2.06254	SWI6	YDL213C|NOP6|S000002372|Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YPL226W	2.05369	SWI6	YPL226W|NEW1|S000006147|ATP binding cassette family member; Asn/Gln-rich rich region supports [NU+] prion formation, susceptibility to [PSI+] prion induction and aggregation of a fragment of the human Machado-Joseph Disease protein
YGR253C	2.04724	SWI6	YGR253C|PUP2|S000003485|Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YJL187C	2.03871	SWI6	YJL187C|SWE1|S000003723|Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YGR192C	2.03701	SWI6	YGR192C|TDH3|S000003424|Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YDL179W	2.03607	SWI6	YDL179W|PCL9|S000002338|Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
YLR432W	2.01679	SWI6	YLR432W|IMD3|S000004424|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YLR348C	2.01035	SWI6	YLR348C|DIC1|S000004340|Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YPL128C	2.00228	SWI6	YPL128C|TBF1|S000006049|Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation
YNL065W	1.99125	SWI6	YNL065W|AQR1|S000005009|Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YOR314W	1.97136	SWI6	YOR314W||S000005841|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL022W	1.97126	SWI6	YGL022W|STT3|S000002990|Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis
YHR172W	1.96625	SWI6	YHR172W|SPC97|S000001215|Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YJR054W	1.96514	SWI6	YJR054W||S000003815|Vacuolar protein of unknown function; potential Cdc28p substrate
YDR297W	1.95798	SWI6	YDR297W|SUR2|S000002705|Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YPL254W	1.95584	SWI6	YPL254W|HFI1|S000006175|Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
YGL135W	1.95533	SWI6	YGL135W|RPL1B|S000003103|N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YDR489W	1.94899	SWI6	YDR489W|SLD5|S000002897|Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YML065W	1.93825	SWI6	YML065W|ORC1|S000004530|Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
YIR019C	1.93244	SWI6	YIR019C|MUC1|S000001458|GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
YKL063C	1.93047	SWI6	YKL063C||S000001546|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YHR153C	1.92703	SWI6	YHR153C|SPO16|S000001196|Protein of unknown function, required for spore formation
YEL054C	1.92548	SWI6	YEL054C|RPL12A|S000000780|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YDR075W	1.91986	SWI6	YDR075W|PPH3|S000002482|Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
YML038C	1.91187	SWI6	YML038C|YMD8|S000004502|Putative nucleotide sugar transporter, has similarity to Vrg4p
YFL016C	1.90956	SWI6	YFL016C|MDJ1|S000001878|Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YDL205C	1.90596	SWI6	YDL205C|HEM3|S000002364|Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YDL023C	1.90455	SWI6	YDL023C||S000002181|Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YJL097W	1.89253	SWI6	YJL097W|PHS1|S000003633|Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking
YER110C	1.88915	SWI6	YER110C|KAP123|S000000912|Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
YOR313C	1.88792	SWI6	YOR313C|SPS4|S000005840|Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YEL068C	1.87942	SWI6	YEL068C||S000000794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL008C	1.87653	SWI6	YKL008C|LAC1|S000001491|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YDL163W	1.85636	SWI6	YDL163W||S000002322|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
YGR180C	1.84342	SWI6	YGR180C|RNR4|S000003412|Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YDR384C	1.8412	SWI6	YDR384C|ATO3|S000002792|Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YER135C	1.83981	SWI6	YER135C||S000000937|Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
YDR488C	1.83769	SWI6	YDR488C|PAC11|S000002896|Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8
YOR153W	1.83639	SWI6	YOR153W|PDR5|S000005679|Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YPR137W	1.83487	SWI6	YPR137W|RRP9|S000006341|Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YBR202W	1.83145	SWI6	YBR202W|MCM7|S000000406|Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YGL076C	1.81788	SWI6	YGL076C|RPL7A|S000003044|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YIL138C	1.8145	SWI6	YIL138C|TPM2|S000001400|Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p
YMR015C	1.81296	SWI6	YMR015C|ERG5|S000004617|C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YBR118W	1.80974	SWI6	YBR118W|TEF2|S000000322|Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YDR133C	1.80471	SWI6	YDR133C||S000002540|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YDR110W	1.80313	SWI6	YDR110W|FOB1|S000002517|Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases
YGR255C	1.79243	SWI6	YGR255C|COQ6|S000003487|Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YGL055W	1.78486	SWI6	YGL055W|OLE1|S000003023|Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YHR064C	1.77586	SWI6	YHR064C|SSZ1|S000001106|Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
YPR136C	1.76665	SWI6	YPR136C||S000006340|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
YJL198W	1.76569	SWI6	YJL198W|PHO90|S000003734|Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YOL109W	1.76159	SWI6	YOL109W|ZEO1|S000005469|Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
YNR001W-A	1.74996	SWI6	YNR001W-A||S000007625|Dubious open reading frame unlikely to encode a functional protein; identified by homology
YBR011C	1.7471	SWI6	YBR011C|IPP1|S000000215|Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YDL037C	1.74622	SWI6	YDL037C|BSC1|S000002195|Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YNL290W	1.74547	SWI6	YNL290W|RFC3|S000005234|Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YDR507C	1.74484	SWI6	YDR507C|GIN4|S000002915|Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
YHR154W	1.74063	SWI6	YHR154W|RTT107|S000001197|Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
YMR205C	1.7333	SWI6	YMR205C|PFK2|S000004818|Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YKL097C	1.7314	SWI6	YKL097C||S000001580|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YIL009C-A	1.72175	SWI6	YIL009C-A|EST3|S000006432|Component of the telomerase holoenzyme, involved in telomere replication
YLR455W	1.72053	SWI6	YLR455W||S000004447|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YKL101W	1.71607	SWI6	YKL101W|HSL1|S000001584|Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YER003C	1.71582	SWI6	YER003C|PMI40|S000000805|Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation
YER011W	1.70718	SWI6	YER011W|TIR1|S000000813|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YIL159W	1.69987	SWI6	YIL159W|BNR1|S000001421|Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
YGL200C	1.68418	SWI6	YGL200C|EMP24|S000003168|Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YDR240C	1.68016	SWI6	YDR240C|SNU56|S000002648|Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YER049W	1.67889	SWI6	YER049W|TPA1|S000000851|Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YDL164C	1.66993	SWI6	YDL164C|CDC9|S000002323|DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
YFR028C	1.65526	SWI6	YFR028C|CDC14|S000001924|Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
YPL112C	1.65422	SWI6	YPL112C|PEX25|S000006033|Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YGR014W	1.65406	SWI6	YGR014W|MSB2|S000003246|Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
YPR175W	1.63949	SWI6	YPR175W|DPB2|S000006379|Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
YAL023C	1.6322	SWI6	YAL023C|PMT2|S000000021|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YDL022W	1.62727	SWI6	YDL022W|GPD1|S000002180|NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YFL017C	1.62185	SWI6	YFL017C|GNA1|S000001877|Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA
YBR249C	1.62173	SWI6	YBR249C|ARO4|S000000453|3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YML085C	1.61522	SWI6	YML085C|TUB1|S000004550|Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
YGL116W	1.6094	SWI6	YGL116W|CDC20|S000003084|Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate
YOL136C	1.60738	SWI6	YOL136C|PFK27|S000005496|6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YHR123W	1.60192	SWI6	YHR123W|EPT1|S000001165|sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YLR179C	1.59113	SWI6	YLR179C||S000004169|Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YER023C-A	1.58871	SWI6	YER023C-A||S000028622|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YBL010C	1.58729	SWI6	YBL010C||S000000106|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
YBR121C	1.58287	SWI6	YBR121C|GRS1|S000000325|Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation
YOR163W	1.57727	SWI6	YOR163W|DDP1|S000005689|Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YDL240W	1.56725	SWI6	YDL240W|LRG1|S000002399|Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YGL202W	1.55613	SWI6	YGL202W|ARO8|S000003170|Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YGR158C	1.55175	SWI6	YGR158C|MTR3|S000003390|3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH
YKR075C	1.54857	SWI6	YKR075C||S000001783|Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YML036W	1.5459	SWI6	YML036W|CGI121|S000004500|Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121
YBL083C	1.54441	SWI6	YBL083C||S000000179|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3
YCR016W	1.53825	SWI6	YCR016W||S000000609|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YOR212W	1.53707	SWI6	YOR212W|STE4|S000005738|G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YER131W	1.53305	SWI6	YER131W|RPS26B|S000000933|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YNL302C	1.5323	SWI6	YNL302C|RPS19B|S000005246|Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap
YGL035C	1.53093	SWI6	YGL035C|MIG1|S000003003|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YOL012C	1.53086	SWI6	YOL012C|HTZ1|S000005372|Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YHR005C	1.52908	SWI6	YHR005C|GPA1|S000001047|GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
YNL248C	1.52377	SWI6	YNL248C|RPA49|S000005192|RNA polymerase I subunit A49
YLR257W	1.52024	SWI6	YLR257W||S000004247|Putative protein of unknown function
YGR031C-A	1.51922	SWI6	YGR031C-A|NAG1|S000028636|Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; null is hypersensitive to calcofluor white; overlaps the uncharacterized ORF YGR031W
YML069W	1.51393	SWI6	YML069W|POB3|S000004534|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)
YOR385W	1.50465	SWI6	YOR385W||S000005912|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
YPL160W	1.49335	SWI6	YPL160W|CDC60|S000006081|Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YPL030W	1.48607	SWI6	YPL030W|TRM44|S000005951|tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
YDR073W	1.48272	SWI6	YDR073W|SNF11|S000002480|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YMR082C	1.48185	SWI6	YMR082C||S000004687|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR094W	1.48102	SWI6	YOR094W|ARF3|S000005620|Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity
YEL066W	1.48006	SWI6	YEL066W|HPA3|S000000792|D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YER118C	1.474	SWI6	YER118C|SHO1|S000000920|Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YNL043C	1.47353	SWI6	YNL043C||S000004988|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YNR009W	1.47263	SWI6	YNR009W|NRM1|S000005292|Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YIL111W	1.47071	SWI6	YIL111W|COX5B|S000001373|Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
YBR252W	1.46773	SWI6	YBR252W|DUT1|S000000456|dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability
YHR071C-A	1.46153	SWI6	YHR071C-A||S000028781|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W
YNL169C	1.45931	SWI6	YNL169C|PSD1|S000005113|Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YDL084W	1.45815	SWI6	YDL084W|SUB2|S000002242|Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56
YDR023W	1.45378	SWI6	YDR023W|SES1|S000002430|Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YDL071C	1.44554	SWI6	YDL071C||S000002229|Hypothetical protein
YGR275W	1.42938	SWI6	YGR275W|RTT102|S000003507|Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition
YIL018W	1.42637	SWI6	YIL018W|RPL2B|S000001280|Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
YHR142W	1.42417	SWI6	YHR142W|CHS7|S000001184|Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER
YLL035W	1.42231	SWI6	YLL035W|GRC3|S000003958|Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated
YKL213C	1.41671	SWI6	YKL213C|DOA1|S000001696|WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
YKL081W	1.41593	SWI6	YKL081W|TEF4|S000001564|Translation elongation factor EF-1 gamma
YBR162W-A	1.41548	SWI6	YBR162W-A|YSY6|S000002158|Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
YDL228C	1.40883	SWI6	YDL228C||S000002387|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1
YPR063C	1.40662	SWI6	YPR063C||S000006267|ER-localized protein of unknown function
YPL081W	1.40655	SWI6	YPL081W|RPS9A|S000006002|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YLR112W	1.38512	SWI6	YLR112W||S000004102|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR062W	1.37733	SWI6	YDR062W|LCB2|S000002469|Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YNR013C	1.37483	SWI6	YNR013C|PHO91|S000005296|Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YPL243W	1.37094	SWI6	YPL243W|SRP68|S000006164|Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YAR008W	1.3704	SWI6	YAR008W|SEN34|S000000066|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YBL063W	1.36788	SWI6	YBL063W|KIP1|S000000159|Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YJL208C	1.36628	SWI6	YJL208C|NUC1|S000003744|Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
YKR043C	1.36319	SWI6	YKR043C||S000001751|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR177C	1.35916	SWI6	YGR177C|ATF2|S000003409|Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YBR069C	1.35805	SWI6	YBR069C|TAT1|S000000273|Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YKL116C	1.35747	SWI6	YKL116C|PRR1|S000001599|Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YJL107C	1.35636	SWI6	YJL107C||S000003643|Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YKL166C	1.34769	SWI6	YKL166C|TPK3|S000001649|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YPL143W	1.34028	SWI6	YPL143W|RPL33A|S000006064|N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YBR243C	1.33815	SWI6	YBR243C|ALG7|S000000447|UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YBR087W	1.33218	SWI6	YBR087W|RFC5|S000000291|Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YOL090W	1.3257	SWI6	YOL090W|MSH2|S000005450|Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP
YEL056W	1.32381	SWI6	YEL056W|HAT2|S000000782|Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YDR502C	1.3233	SWI6	YDR502C|SAM2|S000002910|S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YDL022C-A	1.32321	SWI6	YDL022C-A||S000028537|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YBL003C	1.32081	SWI6	YBL003C|HTA2|S000000099|One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YML001W	1.31595	SWI6	YML001W|YPT7|S000004460|GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7
YAL019W	1.31065	SWI6	YAL019W|FUN30|S000000017|Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL253C	1.30817	SWI6	YPL253C|VIK1|S000006174|Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
YMR146C	1.2986	SWI6	YMR146C|TIF34|S000004754|Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YCR044C	1.29085	SWI6	YCR044C|PER1|S000000640|Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1
YDR013W	1.27651	SWI6	YDR013W|PSF1|S000002420|Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YDR407C	1.27598	SWI6	YDR407C|TRS120|S000002815|One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YAR071W	1.27218	SWI6	YAR071W|PHO11|S000000094|One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YGR181W	1.26959	SWI6	YGR181W|TIM13|S000003413|Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YLR056W	1.26032	SWI6	YLR056W|ERG3|S000004046|C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YPL124W	1.25731	SWI6	YPL124W|SPC29|S000006045|Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication
YBR288C	1.25619	SWI6	YBR288C|APM3|S000000492|Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
YMR173W	1.25574	SWI6	YMR173W|DDR48|S000004784|DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS
YHR152W	1.25318	SWI6	YHR152W|SPO12|S000001195|Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
YOR166C	1.25135	SWI6	YOR166C|SWT1|S000005692|Protein of unknown function; involved in transcription associated process; interacts genetically and physically with the TREX complex and RNA polymerase II; contains a PINc domain (PilT N terminus); localizes in the nucleus
YOL017W	1.24995	SWI6	YOL017W|ESC8|S000005377|Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex
YHR098C	1.24761	SWI6	YHR098C|SFB3|S000001140|Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate
YMR183C	1.23595	SWI6	YMR183C|SSO2|S000004795|Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YCR031C	1.2275	SWI6	YCR031C|RPS14A|S000000627|Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YDR047W	1.22422	SWI6	YDR047W|HEM12|S000002454|Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YLR351C	1.22296	SWI6	YLR351C|NIT3|S000004343|Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YOL011W	1.22284	SWI6	YOL011W|PLB3|S000005371|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YLL064C	1.21435	SWI6	YLL064C|PAU18|S000003987|Hypothetical protein
YLR045C	1.20311	SWI6	YLR045C|STU2|S000004035|Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
YPL042C	1.203	SWI6	YPL042C|SSN3|S000005963|Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
YBR281C	1.20179	SWI6	YBR281C|DUG2|S000000485|Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YMR309C	1.19459	SWI6	YMR309C|NIP1|S000004926|Subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
YLR029C	1.19186	SWI6	YLR029C|RPL15A|S000004019|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YNR054C	1.18919	SWI6	YNR054C|ESF2|S000005337|Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YDL157C	1.1876	SWI6	YDL157C||S000002316|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR052C	1.1869	SWI6	YPR052C|NHP6A|S000006256|High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YGL009C	1.18206	SWI6	YGL009C|LEU1|S000002977|Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YMR173W-A	1.17674	SWI6	YMR173W-A||S000004785|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W
YER057C	1.17463	SWI6	YER057C|HMF1|S000000859|Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
YBR041W	1.17448	SWI6	YBR041W|FAT1|S000000245|Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids
YIL011W	1.17269	SWI6	YIL011W|TIR3|S000001273|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YML026C	1.17202	SWI6	YML026C|RPS18B|S000004488|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YDL103C	1.16837	SWI6	YDL103C|QRI1|S000002261|UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis
YHL003C	1.16745	SWI6	YHL003C|LAG1|S000000995|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YKL113C	1.16539	SWI6	YKL113C|RAD27|S000001596|5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
YLR413W	1.16137	SWI6	YLR413W||S000004405|Putative protein of unknown function; YLR413W is not an essential gene
YDR016C	1.15994	SWI6	YDR016C|DAD1|S000002423|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YMR290C	1.15738	SWI6	YMR290C|HAS1|S000004903|ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YFL008W	1.15685	SWI6	YFL008W|SMC1|S000001886|Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YBL076C	1.15612	SWI6	YBL076C|ILS1|S000000172|Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
YDR112W	1.15238	SWI6	YDR112W|IRC2|S000002519|Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YER074W	1.15192	SWI6	YER074W|RPS24A|S000000876|Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YGR155W	1.15163	SWI6	YGR155W|CYS4|S000003387|Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YMR290W-A	1.13972	SWI6	YMR290W-A||S000004904|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YOR217W	1.13472	SWI6	YOR217W|RFC1|S000005743|Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YBR042C	1.13136	SWI6	YBR042C|CST26|S000000246|Protein of unknown function, affects chromosome stability when overexpressed
YLR049C	1.12484	SWI6	YLR049C||S000004039|Putative protein of unknown function
YHR072W	1.12391	SWI6	YHR072W|ERG7|S000001114|Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YDR189W	1.11984	SWI6	YDR189W|SLY1|S000002597|Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
YKL219W	1.11919	SWI6	YKL219W|COS9|S000001702|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGL226C-A	1.1184	SWI6	YGL226C-A|OST5|S000003194|Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YOR029W	1.1147	SWI6	YOR029W||S000005555|Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YAR002C-A	1.11461	SWI6	YAR002C-A|ERP1|S000002129|Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YGR173W	1.10871	SWI6	YGR173W|RBG2|S000003405|Protein with similarity to mammalian developmentally regulated GTP-binding protein
YLL021W	1.10722	SWI6	YLL021W|SPA2|S000003944|Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YML060W	1.09827	SWI6	YML060W|OGG1|S000004525|Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA
YOR011W	1.09446	SWI6	YOR011W|AUS1|S000005537|Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YML005W	1.0936	SWI6	YML005W|TRM12|S000004464|S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YEL067C	1.09262	SWI6	YEL067C||S000000793|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR398W	1.08311	SWI6	YDR398W|UTP5|S000002806|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDL040C	1.08302	SWI6	YDL040C|NAT1|S000002198|Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YOR108W	1.08053	SWI6	YOR108W|LEU9|S000005634|Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YLL043W	1.07667	SWI6	YLL043W|FPS1|S000003966|Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
YDR012W	1.07601	SWI6	YDR012W|RPL4B|S000002419|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
YOL113W	1.06766	SWI6	YOL113W|SKM1|S000005473|Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth
YIL039W	1.05458	SWI6	YIL039W|TED1|S000001301|Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDL019C	1.05425	SWI6	YDL019C|OSH2|S000002177|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YLL022C	1.05258	SWI6	YLL022C|HIF1|S000003945|Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing
YBL002W	1.05237	SWI6	YBL002W|HTB2|S000000098|One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YOR039W	1.05123	SWI6	YOR039W|CKB2|S000005565|Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
YMR128W	1.04952	SWI6	YMR128W|ECM16|S000004735|Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
YOL086C	1.03888	SWI6	YOL086C|ADH1|S000005446|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YDL212W	1.03391	SWI6	YDL212W|SHR3|S000002371|Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YNL338W	1.03331	SWI6	YNL338W||S000005282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YMR121C	1.03329	SWI6	YMR121C|RPL15B|S000004728|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YNL255C	1.03108	SWI6	YNL255C|GIS2|S000005199|Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway
YAL034W-A	1.03	SWI6	YAL034W-A|MTW1|S000000032|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
YBR104W	1.0277	SWI6	YBR104W|YMC2|S000000308|Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YDR363W-A	1.02664	SWI6	YDR363W-A|SEM1|S000007235|Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
YIL119C	1.01979	SWI6	YIL119C|RPI1|S000001381|Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YHR029C	1.01715	SWI6	YHR029C|YHI9|S000001071|Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
YLR274W	1.01048	SWI6	YLR274W|MCM5|S000004264|Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YBR029C	1.00555	SWI6	YBR029C|CDS1|S000000233|Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
YGL253W	1.00417	SWI6	YGL253W|HXK2|S000003222|Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YKL180W	1.0029	SWI6	YKL180W|RPL17A|S000001663|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YLR222C	0.999955	SWI6	YLR222C|UTP13|S000004212|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YCR098C	0.998207	SWI6	YCR098C|GIT1|S000000695|Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YLR313C	0.997398	SWI6	YLR313C|SPH1|S000004305|Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p
YPL231W	0.993623	SWI6	YPL231W|FAS2|S000006152|Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated
YCR087C-A	0.986012	SWI6	YCR087C-A|LUG1|S000007223|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YML063W	0.984564	SWI6	YML063W|RPS1B|S000004528|Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YLR341W	0.981628	SWI6	YLR341W|SPO77|S000004333|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YIL016W	0.980223	SWI6	YIL016W|SNL1|S000001278|Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
YOR028C	0.973163	SWI6	YOR028C|CIN5|S000005554|Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YMR076C	0.969096	SWI6	YMR076C|PDS5|S000004681|Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes in an interdependent manner, may function as a protein-protein interaction scaffold
YDR276C	0.967051	SWI6	YDR276C|PMP3|S000002684|Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YFR041C	0.96425	SWI6	YFR041C|ERJ5|S000001937|Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
YPL241C	0.961362	SWI6	YPL241C|CIN2|S000006162|GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
YOR276W	0.95999	SWI6	YOR276W|CAF20|S000005802|Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
YDR074W	0.956159	SWI6	YDR074W|TPS2|S000002481|Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YPR033C	0.954691	SWI6	YPR033C|HTS1|S000006237|Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YMR079W	0.953975	SWI6	YMR079W|SEC14|S000004684|Phosphatidylinositol/phosphatidylcholine transfer protein involved in coordinate regulation of PtdIns and PtdCho metabolism, products of which are regulators in Golgi to plasma membrane transport; functionally homologous to mammalian PITPs
YDR412W	0.941552	SWI6	YDR412W|RRP17|S000002820|Component of the pre-60S pre-ribosomal particle; required for cell viability
YPL014W	0.933909	SWI6	YPL014W||S000005935|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YBR007C	0.930586	SWI6	YBR007C|DSF2|S000000211|Deletion suppressor of mpt5 mutation
YGR018C	0.926179	SWI6	YGR018C||S000003250|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W
YDR144C	0.926031	SWI6	YDR144C|MKC7|S000002551|GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YER177W	0.925569	SWI6	YER177W|BMH1|S000000979|14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YJL039C	0.918546	SWI6	YJL039C|NUP192|S000003576|Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
YDR451C	0.917047	SWI6	YDR451C|YHP1|S000002859|One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YAR029W	0.915984	SWI6	YAR029W||S000000077|Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL007W	0.911928	SWI6	YKL007W|CAP1|S000001490|Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YML027W	0.910754	SWI6	YML027W|YOX1|S000004489|Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate
YBR158W	0.910259	SWI6	YBR158W|AMN1|S000000362|Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YNL251C	0.909672	SWI6	YNL251C|NRD1|S000005195|RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
YDR278C	0.904868	SWI6	YDR278C||S000002686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR094C	0.902277	SWI6	YHR094C|HXT1|S000001136|Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YJL061W	0.900083	SWI6	YJL061W|NUP82|S000003597|Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup159p and Nsp1p, interacts with Nup116p and is required for proper localization of Nup116p in the NPC
YCR022C	0.898743	SWI6	YCR022C||S000000616|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YDR449C	0.891736	SWI6	YDR449C|UTP6|S000002857|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YOR241W	0.889046	SWI6	YOR241W|MET7|S000005767|Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA
YDR063W	0.889027	SWI6	YDR063W|AIM7|S000002470|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation)
YJL106W	0.875573	SWI6	YJL106W|IME2|S000003642|Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YBL046W	0.874228	SWI6	YBL046W|PSY4|S000000142|Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus
YLR328W	0.873733	SWI6	YLR328W|NMA1|S000004320|Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YOR277C	0.871319	SWI6	YOR277C||S000005803|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YBR163W	0.871212	SWI6	YBR163W|DEM1|S000000367|Mitochondrial protein of unknown function; null mutant has defects in cell morphology and in response to air drying; may be regulated by the transcription factor Ace2
YOL124C	0.87098	SWI6	YOL124C|TRM11|S000005484|Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YOR143C	0.870221	SWI6	YOR143C|THI80|S000005669|Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YLR065C	0.864274	SWI6	YLR065C||S000004055|Putative protein of unknown function; YLR065C is not an essential gene
YLR085C	0.859436	SWI6	YLR085C|ARP6|S000004075|Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YDR471W	0.857194	SWI6	YDR471W|RPL27B|S000002879|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YNL247W	0.855546	SWI6	YNL247W||S000005191|Essential protein of unknown function; may interact with ribosomes, based on co-purification experiments
YAL040C	0.853921	SWI6	YAL040C|CLN3|S000000038|G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
YJR014W	0.851125	SWI6	YJR014W|TMA22|S000003775|Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1
YCL050C	0.850182	SWI6	YCL050C|APA1|S000000555|Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YMR010W	0.848542	SWI6	YMR010W||S000004612|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1
YGL067W	0.848344	SWI6	YGL067W|NPY1|S000003035|NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
YNL327W	0.843875	SWI6	YNL327W|EGT2|S000005271|Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YDR111C	0.843576	SWI6	YDR111C|ALT2|S000002518|Putative alanine transaminase (glutamic pyruvic transaminase)
YGR280C	0.842288	SWI6	YGR280C|PXR1|S000003512|Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YEL036C	0.839679	SWI6	YEL036C|ANP1|S000000762|Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
YBR038W	0.838682	SWI6	YBR038W|CHS2|S000000242|Chitin synthase II, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for the synthesis of chitin in the primary septum during cytokinesis
YML127W	0.837344	SWI6	YML127W|RSC9|S000004596|Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YCL022C	0.836998	SWI6	YCL022C||S000000527|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
YDR060W	0.831787	SWI6	YDR060W|MAK21|S000002467|Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YNL188W	0.83165	SWI6	YNL188W|KAR1|S000005132|Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
YDL189W	0.830118	SWI6	YDL189W|RBS1|S000002348|Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YDL135C	0.829844	SWI6	YDL135C|RDI1|S000002294|Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p
YOR224C	0.82764	SWI6	YOR224C|RPB8|S000005750|RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YHR046C	0.827093	SWI6	YHR046C|INM1|S000001088|Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YIL132C	0.826902	SWI6	YIL132C|CSM2|S000001394|Protein required for accurate chromosome segregation during meiosis
YNR025C	0.82638	SWI6	YNR025C||S000005308|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase
YGR052W	0.825776	SWI6	YGR052W|FMP48|S000003284|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPR053C	0.820483	SWI6	YPR053C||S000006257|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
YPL141C	0.818567	SWI6	YPL141C||S000006062|Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YPL178W	0.813526	SWI6	YPL178W|CBC2|S000006099|Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YDR346C	0.805515	SWI6	YDR346C|SVF1|S000002754|Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YNR030W	0.802707	SWI6	YNR030W|ALG12|S000005313|Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
YPR156C	0.796916	SWI6	YPR156C|TPO3|S000006360|Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YOL022C	0.796802	SWI6	YOL022C|TSR4|S000005382|Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA
YBR211C	0.793715	SWI6	YBR211C|AME1|S000000415|Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance
YHR089C	0.793529	SWI6	YHR089C|GAR1|S000001131|Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YNL090W	0.789788	SWI6	YNL090W|RHO2|S000005034|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YDR304C	0.783975	SWI6	YDR304C|CPR5|S000002712|Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER
YOR047C	0.783318	SWI6	YOR047C|STD1|S000005573|Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YJR144W	0.783014	SWI6	YJR144W|MGM101|S000003905|Protein involved in mitochondrial genome maintenance; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage
YGL080W	0.782502	SWI6	YGL080W|FMP37|S000003048|Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR227C	0.778758	SWI6	YLR227C|ADY4|S000004217|Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YJL125C	0.776981	SWI6	YJL125C|GCD14|S000003661|Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YOL104C	0.775618	SWI6	YOL104C|NDJ1|S000005464|Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes
YPL062W	0.768713	SWI6	YPL062W||S000005983|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YNL304W	0.768639	SWI6	YNL304W|YPT11|S000005248|Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells
YML043C	0.766263	SWI6	YML043C|RRN11|S000004507|Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YOR096W	0.762435	SWI6	YOR096W|RPS7A|S000005622|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YFL004W	0.761524	SWI6	YFL004W|VTC2|S000001890|Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in protein localization and non-autophagic vacuolar fusion
YLL036C	0.760179	SWI6	YLL036C|PRP19|S000003959|Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases
YMR011W	0.75805	SWI6	YMR011W|HXT2|S000004613|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YGL172W	0.756622	SWI6	YGL172W|NUP49|S000003140|Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes
YCL027W	0.755757	SWI6	YCL027W|FUS1|S000000532|Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
YIL163C	0.755354	SWI6	YIL163C||S000001425|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR142C	0.752267	SWI6	YPR142C||S000006346|Hypothetical protein; open reading frame overlaps 5' end of essential RRP15 gene required for ribosomal RNA processing
YMR172C-A	0.744656	SWI6	YMR172C-A||S000004782|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL291C	0.743832	SWI6	YNL291C|MID1|S000005235|N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
YPR014C	0.743421	SWI6	YPR014C||S000006218|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YBR061C	0.74316	SWI6	YBR061C|TRM7|S000000265|2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
YLR437C	0.742093	SWI6	YLR437C||S000004429|Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YKL065C	0.741486	SWI6	YKL065C|YET1|S000001548|Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YDR206W	0.736696	SWI6	YDR206W|EBS1|S000002614|Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
YPR035W	0.733284	SWI6	YPR035W|GLN1|S000006239|Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
YKR010C	0.731247	SWI6	YKR010C|TOF2|S000001718|Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1
YOR288C	0.728208	SWI6	YOR288C|MPD1|S000005814|Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
YMR208W	0.725487	SWI6	YMR208W|ERG12|S000004821|Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YMR177W	0.723491	SWI6	YMR177W|MMT1|S000004789|Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YOL030W	0.713597	SWI6	YOL030W|GAS5|S000005390|1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YPL221W	0.713141	SWI6	YPL221W|FLC1|S000006142|Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YJR092W	0.708043	SWI6	YJR092W|BUD4|S000003852|Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate
YFR018C	0.706913	SWI6	YFR018C||S000001914|Putative protein of unknown function
YGR050C	0.706469	SWI6	YGR050C||S000003282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL220W	0.704715	SWI6	YPL220W|RPL1A|S000006141|N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YBR078W	0.696991	SWI6	YBR078W|ECM33|S000000282|GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YOR106W	0.696755	SWI6	YOR106W|VAM3|S000005632|Syntaxin-related protein required for vacuolar assembly; functions with Vam7p in vacuolar protein trafficking; member of the syntaxin family of proteins
YMR270C	0.695453	SWI6	YMR270C|RRN9|S000004883|Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
YMR106C	0.694071	SWI6	YMR106C|YKU80|S000004712|Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YIR008C	0.693272	SWI6	YIR008C|PRI1|S000001447|Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YMR125W	0.691131	SWI6	YMR125W|STO1|S000004732|Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
YKR083C	0.682996	SWI6	YKR083C|DAD2|S000001791|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YLR083C	0.682044	SWI6	YLR083C|EMP70|S000004073|Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions
YFL014W	0.680361	SWI6	YFL014W|HSP12|S000001880|Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YLR068W	0.679338	SWI6	YLR068W|FYV7|S000004058|Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
YBR030W	0.678075	SWI6	YBR030W||S000000234|Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold)
YJL060W	0.676255	SWI6	YJL060W|BNA3|S000003596|Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
YOR272W	0.676024	SWI6	YOR272W|YTM1|S000005798|Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YHR143W	0.674444	SWI6	YHR143W|DSE2|S000001186|Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YER113C	0.669831	SWI6	YER113C|TMN3|S000000915|Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
YLR120C	0.665721	SWI6	YLR120C|YPS1|S000004110|Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YLR298C	0.665705	SWI6	YLR298C|YHC1|S000004289|Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YLR380W	0.664253	SWI6	YLR380W|CSR1|S000004372|Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
YMR105W-A	0.662941	SWI6	YMR105W-A||S000028692|Putative protein of unknown function
YOL114C	0.659197	SWI6	YOL114C||S000005474|Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene
YBR160W	0.658874	SWI6	YBR160W|CDC28|S000000364|Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates
YOR105W	0.657043	SWI6	YOR105W||S000005631|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDL085C-A	0.656819	SWI6	YDL085C-A||S000007588|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YMR043W	0.651639	SWI6	YMR043W|MCM1|S000004646|Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
YPL157W	0.64902	SWI6	YPL157W|TGS1|S000006078|Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology
YKL138C-A	0.643428	SWI6	YKL138C-A|HSK3|S000028421|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YIR032C	0.643391	SWI6	YIR032C|DAL3|S000001471|Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YNL292W	0.640717	SWI6	YNL292W|PUS4|S000005236|Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
YMR320W	0.639622	SWI6	YMR320W||S000004939|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR012C	0.638556	SWI6	YBR012C||S000000216|Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YER087C-B	0.6355	SWI6	YER087C-B|SBH1|S000002128|Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p
YIL164C	0.632854	SWI6	YIL164C|NIT1|S000001426|Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YGR162W	0.632827	SWI6	YGR162W|TIF4631|S000003394|Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
YMR016C	0.632413	SWI6	YMR016C|SOK2|S000004618|Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YBR263W	0.63121	SWI6	YBR263W|SHM1|S000000467|Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
YPR129W	0.631199	SWI6	YPR129W|SCD6|S000006333|Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin
YER016W	0.629126	SWI6	YER016W|BIM1|S000000818|Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YEL058W	0.62819	SWI6	YEL058W|PCM1|S000000784|Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YHL009C	0.625541	SWI6	YHL009C|YAP3|S000001001|Basic leucine zipper (bZIP) transcription factor
YPR143W	0.625212	SWI6	YPR143W|RRP15|S000006347|Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
YKR037C	0.624581	SWI6	YKR037C|SPC34|S000001745|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YHR021C	0.618426	SWI6	YHR021C|RPS27B|S000001063|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YGR279C	0.617886	SWI6	YGR279C|SCW4|S000003511|Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YJL186W	0.617723	SWI6	YJL186W|MNN5|S000003722|Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YER027C	0.616258	SWI6	YER027C|GAL83|S000000829|One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain
YOR038C	0.616208	SWI6	YOR038C|HIR2|S000005564|Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
YGR097W	0.615018	SWI6	YGR097W|ASK10|S000003329|Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YJL002C	0.614975	SWI6	YJL002C|OST1|S000003539|Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YDL096C	0.610917	SWI6	YDL096C|OPI6|S000002254|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
YDR046C	0.610638	SWI6	YDR046C|BAP3|S000002453|Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YGR060W	0.610619	SWI6	YGR060W|ERG25|S000003292|C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YCR019W	0.607018	SWI6	YCR019W|MAK32|S000000612|Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YDR371W	0.604739	SWI6	YDR371W|CTS2|S000002779|Sporulation-specific chitinase
YMR184W	0.603563	SWI6	YMR184W|ADD37|S000004796|Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
YOR355W	0.598733	SWI6	YOR355W|GDS1|S000005882|Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YML058W-A	0.598618	SWI6	YML058W-A|HUG1|S000007472|Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage
YKR095W-A	0.598609	SWI6	YKR095W-A|PCC1|S000028512|Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens
YBR022W	0.59707	SWI6	YBR022W|POA1|S000000226|Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
YDR025W	0.597068	SWI6	YDR025W|RPS11A|S000002432|Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YJR076C	0.593985	SWI6	YJR076C|CDC11|S000003837|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YDL095W	0.593764	SWI6	YDL095W|PMT1|S000002253|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt2p, can instead interact with Pmt3p in some conditions; target for new antifungals
YOR025W	0.592661	SWI6	YOR025W|HST3|S000005551|Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YGR287C	0.591567	SWI6	YGR287C||S000003519|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YOL130W	0.590523	SWI6	YOL130W|ALR1|S000005490|Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YOR130C	0.587715	SWI6	YOR130C|ORT1|S000005656|Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YDL028C	0.587339	SWI6	YDL028C|MPS1|S000002186|Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
YEL051W	0.587229	SWI6	YEL051W|VMA8|S000000777|Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YOR317W	0.58719	SWI6	YOR317W|FAA1|S000005844|Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YIL145C	0.586658	SWI6	YIL145C|PAN6|S000001407|Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
YJL138C	0.5859	SWI6	YJL138C|TIF2|S000003674|Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YOR046C	0.585226	SWI6	YOR046C|DBP5|S000005572|Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination
YJR141W	0.583748	SWI6	YJR141W||S000003902|Putative protein of unknown function; may be involved in mRNA processing; YJR141W is an essential gene
YLR442C	0.583275	SWI6	YLR442C|SIR3|S000004434|Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p
YKL119C	0.582051	SWI6	YKL119C|VPH2|S000001602|Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YJL025W	0.581525	SWI6	YJL025W|RRN7|S000003562|Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein
YOL086W-A	0.580685	SWI6	YOL086W-A||S000007626|Putative protein of unknown function; identified by homology
YGL137W	0.579399	SWI6	YGL137W|SEC27|S000003105|Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP
YOR083W	0.579103	SWI6	YOR083W|WHI5|S000005609|Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
YKL190W	0.577053	SWI6	YKL190W|CNB1|S000001673|Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
YOL123W	0.57529	SWI6	YOL123W|HRP1|S000005483|Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YHR081W	0.575243	SWI6	YHR081W|LRP1|S000001123|Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YGR113W	0.574731	SWI6	YGR113W|DAM1|S000003345|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
YDR370C	0.574077	SWI6	YDR370C||S000002778|Putative protein of unknown function
YNL148C	0.57362	SWI6	YNL148C|ALF1|S000005092|Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
YER146W	0.573125	SWI6	YER146W|LSM5|S000000948|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YLR175W	0.572925	SWI6	YLR175W|CBF5|S000004165|Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2
YDR447C	0.571705	SWI6	YDR447C|RPS17B|S000002855|Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YGR017W	0.564666	SWI6	YGR017W||S000003249|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YDL068W	0.56238	SWI6	YDL068W||S000002226|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YOR294W	0.560703	SWI6	YOR294W|RRS1|S000005820|Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice
YGR270C-A	0.557139	SWI6	YGR270C-A||S000028641|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W
YDR185C	0.555312	SWI6	YDR185C||S000002593|Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YLR300W	0.552938	SWI6	YLR300W|EXG1|S000004291|Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YLR404W	0.551254	SWI6	YLR404W|FLD1|S000004396|Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
YDR215C	0.55124	SWI6	YDR215C||S000002623|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YLR194C	0.549322	SWI6	YLR194C||S000004184|Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress
YCL001W	0.549211	SWI6	YCL001W|RER1|S000000507|Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
YLR254C	0.548506	SWI6	YLR254C|NDL1|S000004244|Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
YHR041C	0.546853	SWI6	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YCR004C	0.546755	SWI6	YCR004C|YCP4|S000000597|Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR128C	0.544616	SWI6	YPR128C|ANT1|S000006332|Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation
YJL026C-A	0.543523	SWI6	YJL026C-A||S000028660|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2
YFR039C	0.542365	SWI6	YFR039C||S000001935|Putative protein of unknown function; may be involved in response to high salt and changes in carbon source
YFR009W	0.541654	SWI6	YFR009W|GCN20|S000001905|Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YOR271C	0.541616	SWI6	YOR271C|FSF1|S000005797|Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YML024W	0.541023	SWI6	YML024W|RPS17A|S000004486|Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
YCR052W	0.540476	SWI6	YCR052W|RSC6|S000000648|Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
YJR040W	0.53761	SWI6	YJR040W|GEF1|S000003801|Chloride channel localized to late- or post-Golgi vesicles, involved in iron metabolism; highly homologous to voltage-gated chloride channels in vertebrates
YLR066W	0.536702	SWI6	YLR066W|SPC3|S000004056|Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
YEL037C	0.534896	SWI6	YEL037C|RAD23|S000000763|Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
YPL204W	0.5339	SWI6	YPL204W|HRR25|S000006125|Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
YNR029C	0.533304	SWI6	YNR029C||S000005312|Putative protein of unknown function, deletion confers reduced fitness in saline
YML123C	0.532867	SWI6	YML123C|PHO84|S000004592|High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YGR291C	0.528977	SWI6	YGR291C||S000003523|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR097W	0.528152	SWI6	YJR097W|JJJ3|S000003858|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR032W	0.52774	SWI6	YLR032W|RAD5|S000004022|DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; contains RING finger domain
YKL209C	0.527688	SWI6	YKL209C|STE6|S000001692|Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YMR122W-A	0.526538	SWI6	YMR122W-A||S000007524|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YLR096W	0.52538	SWI6	YLR096W|KIN2|S000004086|Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p
YLR293C	0.524299	SWI6	YLR293C|GSP1|S000004284|GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog
YPR008W	0.523794	SWI6	YPR008W|HAA1|S000006212|Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; involved in adaptation to weak acid stress
YGR293C	0.520038	SWI6	YGR293C||S000003525|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YNR061C	0.520021	SWI6	YNR061C||S000005344|Putative protein of unknown function
YOR368W	0.518822	SWI6	YOR368W|RAD17|S000005895|Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins
YMR006C	0.518083	SWI6	YMR006C|PLB2|S000004608|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YDR534C	0.510999	SWI6	YDR534C|FIT1|S000002942|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YGR047C	0.509578	SWI6	YGR047C|TFC4|S000003279|One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
YDR188W	0.50623	SWI6	YDR188W|CCT6|S000002596|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YDR390C	0.505331	SWI6	YDR390C|UBA2|S000002798|Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YML121W	0.504188	SWI6	YML121W|GTR1|S000004590|Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YIL029C	0.500856	SWI6	YIL029C||S000001291|Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YER028C	0.499233	SWI6	YER028C|MIG3|S000000830|Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
YFL038C	0.494596	SWI6	YFL038C|YPT1|S000001856|Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
YML006C	0.494096	SWI6	YML006C|GIS4|S000004465|CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YDR308C	0.493648	SWI6	YDR308C|SRB7|S000002716|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p
YLR044C	0.491565	SWI6	YLR044C|PDC1|S000004034|Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
YOR058C	0.490427	SWI6	YOR058C|ASE1|S000005584|Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
YGR051C	0.489702	SWI6	YGR051C||S000003283|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YBR096W	0.489481	SWI6	YBR096W||S000000300|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YCR090C	0.487336	SWI6	YCR090C||S000000686|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
YFL026W	0.486436	SWI6	YFL026W|STE2|S000001868|Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YER130C	0.485727	SWI6	YER130C||S000000932|Hypothetical protein
YGL209W	0.485341	SWI6	YGL209W|MIG2|S000003177|Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YOR099W	0.480586	SWI6	YOR099W|KTR1|S000005625|Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YGL111W	0.477555	SWI6	YGL111W|NSA1|S000003079|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YNL316C	0.477141	SWI6	YNL316C|PHA2|S000005260|Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway
YEL042W	0.47705	SWI6	YEL042W|GDA1|S000000768|Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
YHR201C	0.475602	SWI6	YHR201C|PPX1|S000001244|Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YDL069C	0.471163	SWI6	YDL069C|CBS1|S000002227|Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
YBR282W	0.471083	SWI6	YBR282W|MRPL27|S000000486|Mitochondrial ribosomal protein of the large subunit
YMR211W	0.470612	SWI6	YMR211W|DML1|S000004824|Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YOR030W	0.469355	SWI6	YOR030W|DFG16|S000005556|Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YPR163C	0.468431	SWI6	YPR163C|TIF3|S000006367|Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YML097C	0.467451	SWI6	YML097C|VPS9|S000004563|A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
YDR123C	0.467348	SWI6	YDR123C|INO2|S000002530|Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
YJL024C	0.466521	SWI6	YJL024C|APS3|S000003561|Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function
YGL126W	0.463643	SWI6	YGL126W|SCS3|S000003094|Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol
YIR042C	0.462191	SWI6	YIR042C||S000001481|Putative protein of unknown function; YIR042C is a non-essential gene
YOR300W	0.460474	SWI6	YOR300W||S000005826|Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
YPR074C	0.459564	SWI6	YPR074C|TKL1|S000006278|Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YER055C	0.459222	SWI6	YER055C|HIS1|S000000857|ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YHR088W	0.458598	SWI6	YHR088W|RPF1|S000001130|Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
YJR007W	0.45855	SWI6	YJR007W|SUI2|S000003767|Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP
YKL062W	0.457515	SWI6	YKL062W|MSN4|S000001545|Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YML096W	0.457472	SWI6	YML096W||S000004562|Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
YEL047C	0.457012	SWI6	YEL047C||S000000773|Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YMR283C	0.456473	SWI6	YMR283C|RIT1|S000004896|2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
YNR067C	0.455752	SWI6	YNR067C|DSE4|S000005350|Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YDR284C	0.455023	SWI6	YDR284C|DPP1|S000002692|Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YLR353W	0.454843	SWI6	YLR353W|BUD8|S000004345|Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
YOR225W	0.452789	SWI6	YOR225W||S000005751|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGL029W	0.452393	SWI6	YGL029W|CGR1|S000002997|Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YLR265C	0.451922	SWI6	YLR265C|NEJ1|S000004255|Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p
YPL075W	0.451271	SWI6	YPL075W|GCR1|S000005996|Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YBR283C	0.445162	SWI6	YBR283C|SSH1|S000000487|Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YKL118W	0.445136	SWI6	YKL118W||S000001601|Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YER145C-A	0.443492	SWI6	YER145C-A||S000028758|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF LSM5/YER146W
YDR088C	0.440376	SWI6	YDR088C|SLU7|S000002495|RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YML072C	0.439607	SWI6	YML072C|TCB3|S000004537|Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YHR195W	0.438397	SWI6	YHR195W|NVJ1|S000001238|Nuclear envelope protein that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
YNR018W	0.437737	SWI6	YNR018W|AIM38|S000005301|Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YPL019C	0.437178	SWI6	YPL019C|VTC3|S000005940|Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YMR194C-A	0.436923	SWI6	YMR194C-A||S000007250|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL085C	0.43597	SWI6	YOL085C||S000005445|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YJL081C	0.435306	SWI6	YJL081C|ARP4|S000003617|Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YAL029C	0.428941	SWI6	YAL029C|MYO4|S000000027|One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YDR187C	0.428586	SWI6	YDR187C||S000002595|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YIL041W	0.428414	SWI6	YIL041W|GVP36|S000001303|BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
YMR009W	0.428165	SWI6	YMR009W|ADI1|S000004611|Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YAL034C-B	0.426059	SWI6	YAL034C-B||S000002137|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR132C	0.426025	SWI6	YMR132C|JLP2|S000004739|Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
YGR020C	0.425388	SWI6	YGR020C|VMA7|S000003252|Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YER120W	0.424281	SWI6	YER120W|SCS2|S000000922|Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog
YLR286C	0.424185	SWI6	YLR286C|CTS1|S000004276|Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YHR129C	0.423155	SWI6	YHR129C|ARP1|S000001171|Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin
YHL002C-A	0.422371	SWI6	YHL002C-A||S000028770|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL108W	0.420381	SWI6	YPL108W||S000006029|Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YJR047C	0.420045	SWI6	YJR047C|ANB1|S000003808|Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YGR025W	0.418387	SWI6	YGR025W||S000003257|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL021W-A	0.417543	SWI6	YCL021W-A||S000007549|Putative protein of unknown function
YDR288W	0.416155	SWI6	YDR288W|NSE3|S000002696|Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth
YNL323W	0.415389	SWI6	YNL323W|LEM3|S000005267|Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
YLR389C	0.413928	SWI6	YLR389C|STE23|S000004381|Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family
YBR153W	0.411913	SWI6	YBR153W|RIB7|S000000357|Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
YBR066C	0.411261	SWI6	YBR066C|NRG2|S000000270|Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YKR001C	0.410919	SWI6	YKR001C|VPS1|S000001709|Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
YJL218W	0.410586	SWI6	YJL218W||S000003754|Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
YBR081C	0.409737	SWI6	YBR081C|SPT7|S000000285|Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex
YPL244C	0.407877	SWI6	YPL244C|HUT1|S000006165|Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
YKL140W	0.407579	SWI6	YKL140W|TGL1|S000001623|Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YHR025W	0.406845	SWI6	YHR025W|THR1|S000001067|Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YOR127W	0.406696	SWI6	YOR127W|RGA1|S000005653|GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth
YIL094C	0.404937	SWI6	YIL094C|LYS12|S000001356|Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
YLR449W	0.404865	SWI6	YLR449W|FPR4|S000004441|Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YMR319C	0.403925	SWI6	YMR319C|FET4|S000004938|Low-affinity Fe(II) transporter of the plasma membrane
YNR072W	0.401508	SWI6	YNR072W|HXT17|S000005355|Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YFR001W	0.396806	SWI6	YFR001W|LOC1|S000001897|Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YHR032W-A	0.396625	SWI6	YHR032W-A||S000028831|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YNL168C	0.395351	SWI6	YNL168C|FMP41|S000005112|Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR022C	0.392814	SWI6	YLR022C|SDO1|S000004012|Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes
YBR086C	0.389722	SWI6	YBR086C|IST2|S000000290|Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
YDR348C	0.389068	SWI6	YDR348C||S000002756|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate
YGL069C	0.387101	SWI6	YGL069C||S000003037|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
YJL006C	0.386203	SWI6	YJL006C|CTK2|S000003543|Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins
YPL007C	0.385227	SWI6	YPL007C|TFC8|S000005928|One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90
YDR261C	0.384669	SWI6	YDR261C|EXG2|S000002669|Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YNL035C	0.382819	SWI6	YNL035C||S000004980|Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YDR506C	0.379781	SWI6	YDR506C||S000002914|Possible membrane-localized protein
YGR249W	0.379074	SWI6	YGR249W|MGA1|S000003481|Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YLR272C	0.377936	SWI6	YLR272C|YCS4|S000004262|Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin and silencing at the mating type locus
YKL216W	0.377368	SWI6	YKL216W|URA1|S000001699|Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YML054C-A	0.376025	SWI6	YML054C-A||S000028573|Putative protein of unknown function
YGL008C	0.375912	SWI6	YGL008C|PMA1|S000002976|Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; part of the P2 subgroup of cation-transporting ATPases
YBR233W-A	0.375622	SWI6	YBR233W-A|DAD3|S000007595|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YDR355C	0.37322	SWI6	YDR355C||S000002763|Hypothetical protein; open reading frame overlaps 5' end of essential SPC110 gene encoding an inner plaque spindle pole body component
YLR018C	0.373125	SWI6	YLR018C|POM34|S000004008|Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex
YPR114W	0.372872	SWI6	YPR114W||S000006318|Putative protein of unknown function
YGR007W	0.372379	SWI6	YGR007W|MUQ1|S000003239|Choline phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases
YJR124C	0.371247	SWI6	YJR124C||S000003885|Putative protein of unknown function; expression induced under calcium shortage
YDR274C	0.371239	SWI6	YDR274C||S000002682|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR162C	0.371203	SWI6	YOR162C|YRR1|S000005688|Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes
YLR020C	0.370879	SWI6	YLR020C|YEH2|S000004010|Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
YKR026C	0.370569	SWI6	YKR026C|GCN3|S000001734|Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YNL022C	0.369406	SWI6	YNL022C||S000004967|Putative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene
YOR102W	0.368239	SWI6	YOR102W||S000005628|Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex
YOR252W	0.367721	SWI6	YOR252W|TMA16|S000005778|Protein of unknown function that associates with ribosomes
YHL002W	0.367707	SWI6	YHL002W|HSE1|S000000994|Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YIL074C	0.366146	SWI6	YIL074C|SER33|S000001336|3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YOR001W	0.365629	SWI6	YOR001W|RRP6|S000005527|Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
YBR130C	0.362968	SWI6	YBR130C|SHE3|S000000334|Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YPR195C	0.362414	SWI6	YPR195C||S000006399|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR196W	0.361659	SWI6	YLR196W|PWP1|S000004186|Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YMR012W	0.359837	SWI6	YMR012W|CLU1|S000004614|eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YHR183W	0.35797	SWI6	YHR183W|GND1|S000001226|6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress
YKR003W	0.357466	SWI6	YKR003W|OSH6|S000001711|Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YIL139C	0.357385	SWI6	YIL139C|REV7|S000001401|Processivity subunit of DNA polymerase zeta, which is involved in DNA repair and translesion synthesis; required for mutagenesis induced by DNA damage
YLR177W	0.357171	SWI6	YLR177W||S000004167|Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene
YDL047W	0.355255	SWI6	YDL047W|SIT4|S000002205|Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YLR256W	0.355134	SWI6	YLR256W|HAP1|S000004246|Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YER091C	0.354294	SWI6	YER091C|MET6|S000000893|Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YPR148C	0.35394	SWI6	YPR148C||S000006352|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR316C-A	0.351715	SWI6	YOR316C-A||S000028584|Putative protein of unknown function; identified by fungal homology and RT-PCR
YER119C-A	0.351692	SWI6	YER119C-A||S000002961|Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2
YBR276C	0.351065	SWI6	YBR276C|PPS1|S000000480|Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle
YKL117W	0.350922	SWI6	YKL117W|SBA1|S000001600|Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YBR300C	0.350725	SWI6	YBR300C||S000000504|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YHR203C	0.350214	SWI6	YHR203C|RPS4B|S000001246|Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YJR002W	0.350078	SWI6	YJR002W|MPP10|S000003762|Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
YHR182C-A	0.349753	SWI6	YHR182C-A||S000028784|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML059C	0.349134	SWI6	YML059C|NTE1|S000004524|Serine esterase that deacylates exogenous lysophospholipids, homolog of human neuropathy target esterase (NTE); mammalian NTE1 deacylates phosphatidylcholine to glycerophosphocholine
YPL239W	0.348788	SWI6	YPL239W|YAR1|S000006160|Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YOL028C	0.344424	SWI6	YOL028C|YAP7|S000005388|Putative basic leucine zipper (bZIP) transcription factor
YOL087C	0.343467	SWI6	YOL087C||S000005447|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
YPR034W	0.343336	SWI6	YPR034W|ARP7|S000006238|Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YJL140W	0.341721	SWI6	YJL140W|RPB4|S000003676|RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions
YGL065C	0.341472	SWI6	YGL065C|ALG2|S000003033|Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
YGL092W	0.339118	SWI6	YGL092W|NUP145|S000003060|Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p
YOR280C	0.338673	SWI6	YOR280C|FSH3|S000005806|Serine hydrolase; sequence is similar to Fsh1p and Fsh2p
YDR208W	0.338295	SWI6	YDR208W|MSS4|S000002616|Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
YBL016W	0.33787	SWI6	YBL016W|FUS3|S000000112|Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
YDR210W	0.336837	SWI6	YDR210W||S000002618|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YFL056C	0.336808	SWI6	YFL056C|AAD6|S000001838|Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YNR075W	0.336719	SWI6	YNR075W|COS10|S000005358|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YBR182C-A	0.335835	SWI6	YBR182C-A||S000028603|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJL034W	0.334831	SWI6	YJL034W|KAR2|S000003571|ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
YDR414C	0.330231	SWI6	YDR414C|ERD1|S000002822|Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
YML064C	0.329985	SWI6	YML064C|TEM1|S000004529|GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
YOR126C	0.32996	SWI6	YOR126C|IAH1|S000005652|Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing
YLR025W	0.329723	SWI6	YLR025W|SNF7|S000004015|One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
YAR020C	0.325638	SWI6	YAR020C|PAU7|S000000073|Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YDL134C	0.324882	SWI6	YDL134C|PPH21|S000002292|Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YKL064W	0.324712	SWI6	YKL064W|MNR2|S000001547|Putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations
YLR099W-A	0.320333	SWI6	YLR099W-A||S000007618|Putative protein of unknown function
YDR027C	0.319936	SWI6	YDR027C|VPS54|S000002434|Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p
YDR241W	0.319873	SWI6	YDR241W|BUD26|S000002649|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YER048C	0.318524	SWI6	YER048C|CAJ1|S000000850|Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YNL147W	0.317828	SWI6	YNL147W|LSM7|S000005091|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YDR162C	0.316866	SWI6	YDR162C|NBP2|S000002569|Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
YMR198W	0.316239	SWI6	YMR198W|CIK1|S000004811|Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
YJL029C	0.315051	SWI6	YJL029C|VPS53|S000003566|Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YER046W	0.313895	SWI6	YER046W|SPO73|S000000848|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YJR114W	0.311172	SWI6	YJR114W||S000003875|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YOR050C	0.310126	SWI6	YOR050C||S000005576|Hypothetical protein
YML111W	0.309808	SWI6	YML111W|BUL2|S000004579|Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YER058W	0.309648	SWI6	YER058W|PET117|S000000860|Protein required for assembly of cytochrome c oxidase
YKR070W	0.309123	SWI6	YKR070W||S000001778|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR294W	0.308351	SWI6	YGR294W|PAU12|S000003526|Hypothetical protein
YEL061C	0.307448	SWI6	YEL061C|CIN8|S000000787|Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
YDR395W	0.307336	SWI6	YDR395W|SXM1|S000002803|Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
YOR354C	0.307211	SWI6	YOR354C|MSC6|S000005881|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL229C	0.305217	SWI6	YNL229C|URE2|S000005173|Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
YER170W	0.304113	SWI6	YER170W|ADK2|S000000972|Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background
YHR023W	0.304083	SWI6	YHR023W|MYO1|S000001065|Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
YML012W	0.304041	SWI6	YML012W|ERV25|S000004473|Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
YML009C	0.303358	SWI6	YML009C|MRPL39|S000004468|Mitochondrial ribosomal protein of the large subunit
YDL102W	0.301083	SWI6	YDL102W|POL3|S000002260|Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YLR453C	0.300534	SWI6	YLR453C|RIF2|S000004445|Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YHR001W	0.299105	SWI6	YHR001W|OSH7|S000001043|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YCR092C	0.298888	SWI6	YCR092C|MSH3|S000000688|Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability
YCR077C	0.298745	SWI6	YCR077C|PAT1|S000000673|Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
YOR112W	0.29862	SWI6	YOR112W|CEX1|S000005638|Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p
YJR110W	0.296259	SWI6	YJR110W|YMR1|S000003871|Phosphatidylinositol 3-phosphate [PI(3)P] phosphatase, regulates the localization and levels of PI(3)P; involved in cytoplasm to vacuole (CVT) transport; has similarity to the conserved myotubularin dual specificity phosphatase family
YGL158W	0.295638	SWI6	YGL158W|RCK1|S000003126|Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YER133W-A	0.292956	SWI6	YER133W-A||S000028756|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YNL238W	0.288011	SWI6	YNL238W|KEX2|S000005182|Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
YJL160C	0.286802	SWI6	YJL160C||S000003696|Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis
YMR285C	0.285639	SWI6	YMR285C|NGL2|S000004898|Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p
YFL032W	0.283772	SWI6	YFL032W||S000001862|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene
YDR045C	0.28372	SWI6	YDR045C|RPC11|S000002452|RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YBL007C	0.282855	SWI6	YBL007C|SLA1|S000000103|Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
YNL087W	0.281093	SWI6	YNL087W|TCB2|S000005031|Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud
YJR094C	0.280665	SWI6	YJR094C|IME1|S000003854|Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YNL089C	0.279694	SWI6	YNL089C||S000005033|Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
YAR007C	0.278258	SWI6	YAR007C|RFA1|S000000065|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YIL035C	0.278138	SWI6	YIL035C|CKA1|S000001297|Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases
YHR093W	0.278069	SWI6	YHR093W|AHT1|S000001135|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YBR074W	0.27774	SWI6	YBR074W||S000000278|Putative metalloprotease
YML080W	0.27679	SWI6	YML080W|DUS1|S000004545|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
YER048W-A	0.276788	SWI6	YER048W-A|ISD11|S000007237|Protein required for mitochondrial iron-sulfur cluster biosynthesis
YMR098C	0.276787	SWI6	YMR098C|ATP25|S000004704|Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YLL031C	0.276767	SWI6	YLL031C|GPI13|S000003954|ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
YDR535C	0.274499	SWI6	YDR535C||S000002943|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YBR053C	0.271842	SWI6	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YDL077C	0.27081	SWI6	YDL077C|VAM6|S000002235|Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
YJL202C	0.270682	SWI6	YJL202C||S000003738|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex
YNR074C	0.268285	SWI6	YNR074C|AIF1|S000005357|Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
YGR026W	0.268127	SWI6	YGR026W||S000003258|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YJR140C	0.268017	SWI6	YJR140C|HIR3|S000003901|Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly
YLR229C	0.267657	SWI6	YLR229C|CDC42|S000004219|Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YGR001C	0.264304	SWI6	YGR001C|AML1|S000003233|Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
YPL205C	0.263648	SWI6	YPL205C||S000006126|Hypothetical protein; deletion of locus affects telomere length
YDR517W	0.262735	SWI6	YDR517W|GRH1|S000002925|Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YJR113C	0.262014	SWI6	YJR113C|RSM7|S000003874|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YPR021C	0.261857	SWI6	YPR021C|AGC1|S000006225|Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis
YGR120C	0.260745	SWI6	YGR120C|COG2|S000003352|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDL080C	0.260239	SWI6	YDL080C|THI3|S000002238|Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
YER045C	0.25989	SWI6	YER045C|ACA1|S000000847|Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
YER063W	0.25973	SWI6	YER063W|THO1|S000000865|Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
YKR051W	0.259193	SWI6	YKR051W||S000001759|Putative protein of unknown function
YDR172W	0.258464	SWI6	YDR172W|SUP35|S000002579|Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype
YOR269W	0.257842	SWI6	YOR269W|PAC1|S000005795|Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
YIL091C	0.257345	SWI6	YIL091C||S000001353|Protein required for cell viability
YLR221C	0.256552	SWI6	YLR221C|RSA3|S000004211|Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
YLR443W	0.255524	SWI6	YLR443W|ECM7|S000004435|Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency
YHR083W	0.254997	SWI6	YHR083W|SAM35|S000001125|Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YLR321C	0.25306	SWI6	YLR321C|SFH1|S000004313|Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YNL102W	0.252933	SWI6	YNL102W|POL1|S000005046|Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
YML125C	0.251958	SWI6	YML125C|PGA3|S000004594|Essential protein required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect
YOR260W	0.247589	SWI6	YOR260W|GCD1|S000005786|Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YOL112W	0.246981	SWI6	YOL112W|MSB4|S000005472|GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
YPL170W	0.245487	SWI6	YPL170W|DAP1|S000006091|Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
YKL114C	0.245098	SWI6	YKL114C|APN1|S000001597|Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
YLR230W	0.243974	SWI6	YLR230W||S000004220|Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
YDR109C	0.242586	SWI6	YDR109C||S000002516|Putative kinase
YLR421C	0.241124	SWI6	YLR421C|RPN13|S000004413|Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome
YDR434W	0.240803	SWI6	YDR434W|GPI17|S000002842|Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
YCR015C	0.238083	SWI6	YCR015C||S000000608|Putative protein of unknown function; YCR015C is not an essential gene
YPL130W	0.23602	SWI6	YPL130W|SPO19|S000006051|Meiosis-specific protein of unknown function, involved in completion of nuclear divisions; identified as a weak high-copy suppressor of the spo1-1 ts mutation; putative GPI-dependent cell-wall protein
YCR002C	0.235703	SWI6	YCR002C|CDC10|S000000595|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YKL033W-A	0.235126	SWI6	YKL033W-A||S000007242|Putative protein of unknown function; similar to uncharacterized proteins from other fungi
YBL079W	0.233706	SWI6	YBL079W|NUP170|S000000175|Abundant subunit of the nuclear pore complex (NPC), required for proper localization of specific nucleoporins within the NPC, involved in nuclear envelope permeability and in chromosome segregation, has similarity to Nup157p
YBL041W	0.232159	SWI6	YBL041W|PRE7|S000000137|Beta 6 subunit of the 20S proteasome
YML071C	0.231232	SWI6	YML071C|COG8|S000004536|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YKL049C	0.231011	SWI6	YKL049C|CSE4|S000001532|Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A
YOR013W	0.230761	SWI6	YOR013W|IRC11|S000005539|Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YNL253W	0.229626	SWI6	YNL253W|TEX1|S000005197|Protein involved in mRNA export, component of the transcription export (TREX) complex
YLR401C	0.228438	SWI6	YLR401C|DUS3|S000004393|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YHR121W	0.227914	SWI6	YHR121W|LSM12|S000001163|Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS
YBL004W	0.225971	SWI6	YBL004W|UTP20|S000000100|Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
YER183C	0.224889	SWI6	YER183C|FAU1|S000000985|5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YLR238W	0.22404	SWI6	YLR238W|FAR10|S000004228|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
YLR302C	0.223675	SWI6	YLR302C||S000004293|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL043C	0.223477	SWI6	YIL043C|CBR1|S000001305|Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
YBL097W	0.222391	SWI6	YBL097W|BRN1|S000000193|Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics
YEL014C	0.222349	SWI6	YEL014C||S000000740|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL143W	0.221965	SWI6	YKL143W|LTV1|S000001626|Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
YLR424W	0.220211	SWI6	YLR424W|SPP382|S000004416|Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
YEL013W	0.217555	SWI6	YEL013W|VAC8|S000000739|Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
YGL088W	0.216479	SWI6	YGL088W||S000003056|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YHR084W	0.215678	SWI6	YHR084W|STE12|S000001126|Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
YOR082C	0.214973	SWI6	YOR082C||S000005608|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
YKL144C	0.214761	SWI6	YKL144C|RPC25|S000001627|RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
YER168C	0.214465	SWI6	YER168C|CCA1|S000000970|ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
YPR194C	0.214423	SWI6	YPR194C|OPT2|S000006398|Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans
YBR149W	0.214283	SWI6	YBR149W|ARA1|S000000353|NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product
YDR089W	0.21418	SWI6	YDR089W||S000002496|Protein of unknown function; deletion confers resistance to Nickel
YDR207C	0.213337	SWI6	YDR207C|UME6|S000002615|Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
YAL026C	0.212684	SWI6	YAL026C|DRS2|S000000024|Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
YHL013C	0.211909	SWI6	YHL013C|OTU2|S000001005|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
YCR009C	0.210247	SWI6	YCR009C|RVS161|S000000602|Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
YDR005C	0.209178	SWI6	YDR005C|MAF1|S000002412|Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB
YBL006C	0.207773	SWI6	YBL006C|LDB7|S000000102|Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YGL085W	0.207607	SWI6	YGL085W||S000003053|Putative protein of unknown function, has homology to Staphylococcus aureus nuclease; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS
YFL027C	0.205162	SWI6	YFL027C|GYP8|S000001867|GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YOL091W	0.204215	SWI6	YOL091W|SPO21|S000005451|Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YNL236W	0.203433	SWI6	YNL236W|SIN4|S000005180|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription
YKR099W	0.202416	SWI6	YKR099W|BAS1|S000001807|Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YOR298W	0.199205	SWI6	YOR298W|MUM3|S000005824|Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases
YOR251C	0.19841	SWI6	YOR251C||S000005777|Putative protein of unknown function with similarity to human thiosulfate sulfurtransferase, an enzyme that catalyzes the transfer of sulfur from thiosulfate to cyanide, forming sulfite and thiocyanate; YOR251C is a non-essential gene
YMR245W	0.197469	SWI6	YMR245W||S000004859|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR192W	0.196589	SWI6	YBR192W|RIM2|S000000396|Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YPL146C	0.19588	SWI6	YPL146C|NOP53|S000006067|Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YBR177C	0.195416	SWI6	YBR177C|EHT1|S000000381|Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YEL034C-A	0.195124	SWI6	YEL034C-A||S000028743|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YDL002C	0.195046	SWI6	YDL002C|NHP10|S000002160|Protein related to mammalian high mobility group proteins; likely component of the INO80 complex, which is an ATP-dependent chromatin-remodeling complex
YOR085W	0.194253	SWI6	YOR085W|OST3|S000005611|Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
YLR322W	0.194032	SWI6	YLR322W|VPS65|S000004314|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect
YDL078C	0.193101	SWI6	YDL078C|MDH3|S000002236|Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YLR400W	0.19304	SWI6	YLR400W||S000004392|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL134C	0.191992	SWI6	YOL134C||S000005494|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
YOR122C	0.189365	SWI6	YOR122C|PFY1|S000005648|Profilin, actin- and phosphatidylinositol 4,5-bisphosphate-binding protein, involved in cytoskeleton organization, required for normal timing of actin polymerization in response to thermal stress; localizes to plasma membrane and cytosol
YDL165W	0.188029	SWI6	YDL165W|CDC36|S000002324|Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YGR240C	0.187362	SWI6	YGR240C|PFK1|S000003472|Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YER133W	0.186563	SWI6	YER133W|GLC7|S000000935|Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
YPR074W-A	0.186205	SWI6	YPR074W-A||S000007631|Hypothetical protein identified by homology
YIR007W	0.184102	SWI6	YIR007W||S000001446|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
YAL009W	0.183905	SWI6	YAL009W|SPO7|S000000007|Regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation
YNL273W	0.183295	SWI6	YNL273W|TOF1|S000005217|Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
YDR180W	0.182938	SWI6	YDR180W|SCC2|S000002588|Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin
YHR027C	0.182848	SWI6	YHR027C|RPN1|S000001069|Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions
YLR099C	0.181315	SWI6	YLR099C|ICT1|S000004089|Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress
YLL018C	0.181291	SWI6	YLL018C|DPS1|S000003941|Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YPR122W	0.17972	SWI6	YPR122W|AXL1|S000006326|Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
YCR008W	0.178249	SWI6	YCR008W|SAT4|S000000601|Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YBL098W	0.177021	SWI6	YBL098W|BNA4|S000000194|Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease
YER165W	0.176154	SWI6	YER165W|PAB1|S000000967|Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
YOR335C	0.176005	SWI6	YOR335C|ALA1|S000005862|Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
YGR247W	0.175299	SWI6	YGR247W|CPD1|S000003479|Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression
YLR088W	0.173898	SWI6	YLR088W|GAA1|S000004078|Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER
YLR081W	0.173044	SWI6	YLR081W|GAL2|S000004071|Galactose permease, required for utilization of galactose; also able to transport glucose
YLR019W	0.172889	SWI6	YLR019W|PSR2|S000004009|Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YPR173C	0.17223	SWI6	YPR173C|VPS4|S000006377|AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism
YHR076W	0.171635	SWI6	YHR076W|PTC7|S000001118|Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YER088C-A	0.170327	SWI6	YER088C-A||S000028754|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL184W	0.169734	SWI6	YKL184W|SPE1|S000001667|Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines
YJR011C	0.168522	SWI6	YJR011C||S000003772|Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YDL090C	0.166349	SWI6	YDL090C|RAM1|S000002248|Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
YDR179W-A	0.165777	SWI6	YDR179W-A||S000002587|Putative protein of unknown function
YDL048C	0.165686	SWI6	YDL048C|STP4|S000002206|Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YBR268W	0.164806	SWI6	YBR268W|MRPL37|S000000472|Mitochondrial ribosomal protein of the large subunit
YFL010W-A	0.164651	SWI6	YFL010W-A|AUA1|S000001955|Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
YOR367W	0.164414	SWI6	YOR367W|SCP1|S000005894|Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin
YDR302W	0.162551	SWI6	YDR302W|GPI11|S000002710|ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YOR144C	0.160086	SWI6	YOR144C|ELG1|S000005670|Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
YOR118W	0.15666	SWI6	YOR118W|RTC5|S000005644|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
YNL207W	0.155881	SWI6	YNL207W|RIO2|S000005151|Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YKR027W	0.155175	SWI6	YKR027W|BCH2|S000001735|Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YBL036C	0.154244	SWI6	YBL036C||S000000132|Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YDR503C	0.153834	SWI6	YDR503C|LPP1|S000002911|Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA
YDL171C	0.153434	SWI6	YDL171C|GLT1|S000002330|NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YDR433W	0.153332	SWI6	YDR433W||S000002841|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML062C	0.153052	SWI6	YML062C|MFT1|S000004527|Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance
YJL201W	0.153015	SWI6	YJL201W|ECM25|S000003737|Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p
YOR352W	0.152424	SWI6	YOR352W||S000005879|Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YBR156C	0.151836	SWI6	YBR156C|SLI15|S000000360|Subunit of the Ipl1p-Sli15p-Bir1p complex that regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; regulates the activity and localization of the Ipl1p aurora kinase
YPR108W	0.149836	SWI6	YPR108W|RPN7|S000006312|Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
YFR048W	0.149684	SWI6	YFR048W|RMD8|S000001944|Cytosolic protein required for sporulation
YLR244C	0.14759	SWI6	YLR244C|MAP1|S000004234|Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p
YNL275W	0.147359	SWI6	YNL275W|BOR1|S000005219|Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1
YMR029C	0.147352	SWI6	YMR029C|FAR8|S000004631|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
YAL010C	0.147105	SWI6	YAL010C|MDM10|S000000008|Subunit of both the Mdm10-Mdm12-Mmm1 complex and the mitochondrial sorting and assembly machinery (SAM complex); functions in both the general and Tom40p-specific pathways for import and assembly of outer membrane beta-barrel proteins
YCR003W	0.146014	SWI6	YCR003W|MRPL32|S000000596|Mitochondrial ribosomal protein of the large subunit
YLR407W	0.145641	SWI6	YLR407W||S000004399|Putative protein of unknown function; YLR407W is not an essential gene
YOR043W	0.145123	SWI6	YOR043W|WHI2|S000005569|Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YNR014W	0.144405	SWI6	YNR014W||S000005297|Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YGL149W	0.144374	SWI6	YGL149W||S000003117|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
YHR140W	0.143982	SWI6	YHR140W||S000001182|Putative integral membrane protein of unknown function
YLR021W	0.143534	SWI6	YLR021W|IRC25|S000004011|Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YNL061W	0.143232	SWI6	YNL061W|NOP2|S000005005|Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
YEL015W	0.142697	SWI6	YEL015W|EDC3|S000000741|Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies
YEL022W	0.141535	SWI6	YEL022W|GEA2|S000000748|Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p
YGL100W	0.141381	SWI6	YGL100W|SEH1|S000003068|Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p
YMR218C	0.141064	SWI6	YMR218C|TRS130|S000004831|One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1
YBR014C	0.139852	SWI6	YBR014C|GRX7|S000000218|Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6
YDR337W	0.138132	SWI6	YDR337W|MRPS28|S000002745|Mitochondrial ribosomal protein of the small subunit
YGR146C-A	0.135426	SWI6	YGR146C-A||S000028638|Putative protein of unknown function
YER112W	0.13458	SWI6	YER112W|LSM4|S000000914|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YJR025C	0.134468	SWI6	YJR025C|BNA1|S000003786|3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YMR247C	0.134369	SWI6	YMR247C|RKR1|S000004861|Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene
YDR498C	0.134242	SWI6	YDR498C|SEC20|S000002906|Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p
YLL024C	0.131847	SWI6	YLL024C|SSA2|S000003947|ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall
YHR017W	0.131768	SWI6	YHR017W|YSC83|S000001059|Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
YPL047W	0.130807	SWI6	YPL047W|SGF11|S000005968|Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
YGR168C	0.130742	SWI6	YGR168C||S000003400|Putative protein of unknown function; YGR168C is not an essential gene
YLR027C	0.1302	SWI6	YLR027C|AAT2|S000004017|Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YHR120W	0.129911	SWI6	YHR120W|MSH1|S000001162|DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
YJL164C	0.129536	SWI6	YJL164C|TPK1|S000003700|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
YMR149W	0.127846	SWI6	YMR149W|SWP1|S000004757|Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
YGL113W	0.127484	SWI6	YGL113W|SLD3|S000003081|Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p
YER081W	0.12727	SWI6	YER081W|SER3|S000000883|3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p
YBR279W	0.126802	SWI6	YBR279W|PAF1|S000000483|RNAP II-associated protein; defines large complex biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme; required for full expression of a subset of cell cycle-regulated genes; homolog of human PD2/hPAF1
YJL030W	0.125421	SWI6	YJL030W|MAD2|S000003567|Component of the spindle-assembly checkpoint complex, which delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p
YDL161W	0.12474	SWI6	YDL161W|ENT1|S000002320|Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus
YPL259C	0.124582	SWI6	YPL259C|APM1|S000006180|Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
YKL015W	0.124236	SWI6	YKL015W|PUT3|S000001498|Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain
YDR008C	0.123672	SWI6	YDR008C||S000002415|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR394C-A	0.123565	SWI6	YOR394C-A||S000028718|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJL095W	0.121749	SWI6	YJL095W|BCK1|S000003631|Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
YLR067C	0.121665	SWI6	YLR067C|PET309|S000004057|Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane
YNL208W	0.120708	SWI6	YNL208W||S000005152|Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi
YJL001W	0.119675	SWI6	YJL001W|PRE3|S000003538|Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
YDR491C	0.119266	SWI6	YDR491C||S000002899|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL006C	0.118867	SWI6	YOL006C|TOP1|S000005366|Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YNL062C	0.117804	SWI6	YNL062C|GCD10|S000005006|Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YFL031W	0.117109	SWI6	YFL031W|HAC1|S000001863|bZIP transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway utilizing Ire1p, Trl1p and Ada5p facilitates efficient Hac1p synthesis
YDL108W	0.116408	SWI6	YDL108W|KIN28|S000002266|Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
YML019W	0.116303	SWI6	YML019W|OST6|S000004481|Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
YNL064C	0.116206	SWI6	YNL064C|YDJ1|S000005008|Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
YJL216C	0.116168	SWI6	YJL216C||S000003752|Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YGR024C	0.115384	SWI6	YGR024C|THG1|S000003256|tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
YBR201W	0.115275	SWI6	YBR201W|DER1|S000000405|Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
YEL033W	0.115153	SWI6	YEL033W|MTC7|S000000759|Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YJL028W	0.114751	SWI6	YJL028W||S000003565|Protein of unknown function; may interact with ribosomes, based on co-purification experiments
YOL054W	0.11449	SWI6	YOL054W|PSH1|S000005415|Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein
YKL185W	0.114415	SWI6	YKL185W|ASH1|S000001668|Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
YDR448W	0.114268	SWI6	YDR448W|ADA2|S000002856|Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
YPR185W	0.113445	SWI6	YPR185W|ATG13|S000006389|Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
YKL201C	0.112487	SWI6	YKL201C|MNN4|S000001684|Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
YML086C	0.110901	SWI6	YML086C|ALO1|S000004551|D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of D-erythroascorbic acid, which is protective against oxidative stress
YOL102C	0.110479	SWI6	YOL102C|TPT1|S000005462|tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
YML031C-A	0.110035	SWI6	YML031C-A||S000028809|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS
YGL194C-A	0.108212	SWI6	YGL194C-A||S000087160|Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
YER068W	0.107935	SWI6	YER068W|MOT2|S000000870|Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
YBR289W	0.107582	SWI6	YBR289W|SNF5|S000000493|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p
YLR079W	0.107555	SWI6	YLR079W|SIC1|S000004069|Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1
YOR267C	0.107023	SWI6	YOR267C|HRK1|S000005793|Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
YGL177W	0.106394	SWI6	YGL177W||S000003145|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL043C	0.10541	SWI6	YCL043C|PDI1|S000000548|Protein disulfide isomerase, multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds
YOR174W	0.105063	SWI6	YOR174W|MED4|S000005700|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YGR049W	0.104417	SWI6	YGR049W|SCM4|S000003281|Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
YLR412C-A	0.103802	SWI6	YLR412C-A||S000028572|Putative protein of unknown function
YIR010W	0.103766	SWI6	YIR010W|DSN1|S000001449|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
YBR044C	0.101917	SWI6	YBR044C|TCM62|S000000248|Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YNL263C	0.101725	SWI6	YNL263C|YIF1|S000005207|Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles
YGR223C	0.101502	SWI6	YGR223C|HSV2|S000003455|Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
YKL186C	0.101207	SWI6	YKL186C|MTR2|S000001669|mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
YIL066W-A	0.101063	SWI6	YIL066W-A||S000028791|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL116W	0.100493	SWI6	YDL116W|NUP84|S000002274|Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis
YDR228C	0.0998917	SWI6	YDR228C|PCF11|S000002636|mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
YPR080W	0.0985669	SWI6	YPR080W|TEF1|S000006284|Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YOR018W	0.0977359	SWI6	YOR018W|ROD1|S000005544|Membrane protein; overexpression confers resistance to the GST substrate o-dinitrobenzene as well as to zinc and calcium; contains 2 PY motifs, which are required for Rod1p interaction with Rsp5p, a hect-type ubiquitin ligase
YML031W	0.0977157	SWI6	YML031W|NDC1|S000004493|Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II
YOR048C	0.0970638	SWI6	YOR048C|RAT1|S000005574|Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination
YPL049C	0.0958495	SWI6	YPL049C|DIG1|S000005970|Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YIL063C	0.0947073	SWI6	YIL063C|YRB2|S000001325|Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential
YOR266W	0.0944408	SWI6	YOR266W|PNT1|S000005792|Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine
YER014W	0.0942005	SWI6	YER014W|HEM14|S000000816|Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX
YFR031C	0.0937833	SWI6	YFR031C|SMC2|S000001927|Component of the condensin complex, essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA, possibly in the cleft formed by the coiled-coil of the folded dimer
YDR356W	0.0937514	SWI6	YDR356W|SPC110|S000002764|Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
YMR316C-A	0.0936675	SWI6	YMR316C-A||S000004933|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene DIA1/YMR316W
YAR003W	0.0933382	SWI6	YAR003W|SWD1|S000000064|Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7
YOR008C	0.0921847	SWI6	YOR008C|SLG1|S000005534|Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway involved in maintenance of cell wall integrity; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
YFL017W-A	0.0915616	SWI6	YFL017W-A|SMX2|S000002965|Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
YOR370C	0.0912666	SWI6	YOR370C|MRS6|S000005897|Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
YGR270W	0.0905436	SWI6	YGR270W|YTA7|S000003502|Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p
YEL048C	0.0897867	SWI6	YEL048C||S000000774|Putative protein of unknown function; synthetic lethal with gcs1delta
YFL010C	0.0897074	SWI6	YFL010C|WWM1|S000001884|WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1
YCR020W-B	0.0895793	SWI6	YCR020W-B|HTL1|S000006439|Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
YMR135W-A	0.0893364	SWI6	YMR135W-A||S000004743|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL028W	0.0891205	SWI6	YIL028W||S000001290|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL121C	0.0885133	SWI6	YPL121C|MEI5|S000006042|Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p
YJR072C	0.0884039	SWI6	YJR072C|NPA3|S000003833|Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex
YDR349C	0.0882496	SWI6	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YPL217C	0.088183	SWI6	YPL217C|BMS1|S000006138|Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p
YJL104W	0.0874903	SWI6	YJL104W|PAM16|S000003640|Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain
YHL031C	0.0873903	SWI6	YHL031C|GOS1|S000001023|v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YAL022C	0.0860439	SWI6	YAL022C|FUN26|S000000020|Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes
YPR058W	0.0853228	SWI6	YPR058W|YMC1|S000006262|Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p
YDR145W	0.0853025	SWI6	YDR145W|TAF12|S000002552|Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YDR492W	0.0848925	SWI6	YDR492W|IZH1|S000002900|Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YDR197W	0.0839183	SWI6	YDR197W|CBS2|S000002605|Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
YBL029W	0.0833297	SWI6	YBL029W||S000000125|Non-essential protein of unknown function
YNR051C	0.0830624	SWI6	YNR051C|BRE5|S000005334|Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
YBR073W	0.082198	SWI6	YBR073W|RDH54|S000000277|DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference
YKL068W	0.0819759	SWI6	YKL068W|NUP100|S000001551|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
YJL143W	0.081706	SWI6	YJL143W|TIM17|S000003679|Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import
YIL126W	0.0798596	SWI6	YIL126W|STH1|S000001388|ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YDL117W	0.0781336	SWI6	YDL117W|CYK3|S000002275|SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
YGL125W	0.0779301	SWI6	YGL125W|MET13|S000003093|Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YJL004C	0.0767262	SWI6	YJL004C|SYS1|S000003541|Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
YMR197C	0.0752871	SWI6	YMR197C|VTI1|S000004810|Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways
YBR024W	0.0751124	SWI6	YBR024W|SCO2|S000000228|Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YJR099W	0.073946	SWI6	YJR099W|YUH1|S000003860|Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YOR014W	0.0735755	SWI6	YOR014W|RTS1|S000005540|B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
YCR093W	0.072586	SWI6	YCR093W|CDC39|S000000689|Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YPL016W	0.0718616	SWI6	YPL016W|SWI1|S000005937|Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can become prion [SWI+]
YEL032W	0.0717917	SWI6	YEL032W|MCM3|S000000758|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YLR078C	0.0703913	SWI6	YLR078C|BOS1|S000004068|v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YBR072C-A	0.0701922	SWI6	YBR072C-A||S000028532|Putative protein of unknown function; identified by fungal homology and RT-PCR
YMR036C	0.0691508	SWI6	YMR036C|MIH1|S000004639|Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
YBL104C	0.0688606	SWI6	YBL104C||S000000200|Putative protein of unknown function, promoter contains multiple GCN4 binding sites
YNL085W	0.0685966	SWI6	YNL085W|MKT1|S000005029|Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO endonuclease; involved in propagation of M2 dsRNA satellite of L-A virus; contains a DTG signature typical of retroviral proteases
YHR086W-A	0.0677265	SWI6	YHR086W-A||S000028552|Putative protein of unknown function; identified by fungal homology and RT-PCR
YBL021C	0.0675513	SWI6	YBL021C|HAP3|S000000117|Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
YJL031C	0.0675353	SWI6	YJL031C|BET4|S000003568|Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p
YOR203W	0.0666424	SWI6	YOR203W||S000005729|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation
YNL224C	0.0653363	SWI6	YNL224C|SQS1|S000005168|Protein of unknown function; overexpression antagonizes the suppression of splicing defects by spp382 mutants; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YJL129C	0.0652377	SWI6	YJL129C|TRK1|S000003665|Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation
YNL315C	0.0645027	SWI6	YNL315C|ATP11|S000005259|Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YGL047W	0.0644948	SWI6	YGL047W|ALG13|S000003015|Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases
YGR005C	0.0625562	SWI6	YGR005C|TFG2|S000003237|TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30
YJR086W	0.0624457	SWI6	YJR086W|STE18|S000003846|G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling
YER092W	0.0615334	SWI6	YER092W|IES5|S000000894|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YCL061C	0.0613849	SWI6	YCL061C|MRC1|S000000566|S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
YLR171W	0.0604571	SWI6	YLR171W||S000004161|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR072W-B	0.0594694	SWI6	YOR072W-B||S000028516|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YNL186W	0.0589048	SWI6	YNL186W|UBP10|S000005130|Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
YMR086C-A	0.0583438	SWI6	YMR086C-A||S000004691|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL225C	0.0576168	SWI6	YNL225C|CNM67|S000005169|Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration
YOR095C	0.0570137	SWI6	YOR095C|RKI1|S000005621|Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YKL045W	0.0569568	SWI6	YKL045W|PRI2|S000001528|Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YEL031W	0.0569296	SWI6	YEL031W|SPF1|S000000757|P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
YPL153C	0.0568273	SWI6	YPL153C|RAD53|S000006074|Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
YHL038C	0.0566337	SWI6	YHL038C|CBP2|S000001030|Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
YNL076W	0.0557929	SWI6	YNL076W|MKS1|S000005020|Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
YDL185C-A	0.0555109	SWI6	YDL185C-A||S000007600|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species
YGL228W	0.0548914	SWI6	YGL228W|SHE10|S000003197|Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest
YDR499W	0.0536998	SWI6	YDR499W|LCD1|S000002907|Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP
YLR168C	0.0536368	SWI6	YLR168C|AIM30|S000004158|Putative protein of unknown function that may be involved in intramitochondrial sorting; similar to Ups1p and to human PRELI; GFP-tagged protein localizes to mitochondria; required for wild-type respiratory growth
YER155C	0.0535665	SWI6	YER155C|BEM2|S000000957|Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence
YMR207C	0.0532605	SWI6	YMR207C|HFA1|S000004820|Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis
YKL135C	0.052894	SWI6	YKL135C|APL2|S000001618|Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting
YJL128C	0.0513566	SWI6	YJL128C|PBS2|S000003664|MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition
YBL052C	0.0513213	SWI6	YBL052C|SAS3|S000000148|Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality
YOR301W	0.0512426	SWI6	YOR301W|RAX1|S000005827|Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
YDR051C	0.0511267	SWI6	YDR051C||S000002458|Protein of unknown function; interacts with Hsp82p in two-hybrid assay; deletion confers sensitivity to Nickel
YIL071C	0.0505596	SWI6	YIL071C|PCI8|S000001333|Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
YDR195W	0.0503127	SWI6	YDR195W|REF2|S000002603|RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
YHR004C	0.0499847	SWI6	YHR004C|NEM1|S000001046|Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation
YGL048C	0.0495221	SWI6	YGL048C|RPT6|S000003016|One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle
YEL057C	0.0493	SWI6	YEL057C||S000000783|Protein of unknown function involved in telomere maintenance; target of UME6 regulation
YMR316W	0.0463747	SWI6	YMR316W|DIA1|S000004935|Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL262W	0.0463519	SWI6	YGL262W||S000003231|Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
YBR271W	0.0458767	SWI6	YBR271W||S000000475|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene
YLR195C	0.0457739	SWI6	YLR195C|NMT1|S000004185|N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
YDR129C	0.0445526	SWI6	YDR129C|SAC6|S000002536|Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YOR033C	0.0439523	SWI6	YOR033C|EXO1|S000005559|5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
YHL030W	0.0437908	SWI6	YHL030W|ECM29|S000001022|Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
YER019W	0.0427211	SWI6	YER019W|ISC1|S000000821|Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance
YJL159W	0.0426434	SWI6	YJL159W|HSP150|S000003695|O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation
YLR329W	0.0414722	SWI6	YLR329W|REC102|S000004321|Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
YER188W	0.0414279	SWI6	YER188W||S000000990|Hypothetical protein
YDL185W	0.0392178	SWI6	YDL185W|TFP1|S000002344|Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
YOR306C	0.0381277	SWI6	YOR306C|MCH5|S000005833|Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
YGR231C	0.0378335	SWI6	YGR231C|PHB2|S000003463|Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YMR136W	0.037585	SWI6	YMR136W|GAT2|S000004744|Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
YPR121W	0.0375222	SWI6	YPR121W|THI22|S000006325|Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YER062C	0.0371388	SWI6	YER062C|HOR2|S000000864|One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
YPR149W	0.0362096	SWI6	YPR149W|NCE102|S000006353|Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YOL142W	0.0362081	SWI6	YOL142W|RRP40|S000005502|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YMR008C	0.0361605	SWI6	YMR008C|PLB1|S000004610|Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YML108W	0.0360301	SWI6	YML108W||S000004576|Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene
YOR297C	0.0358089	SWI6	YOR297C|TIM18|S000005823|Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane; may function to stabilize the complex
YFR042W	0.0355226	SWI6	YFR042W|KEG1|S000001938|Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
YPL120W	0.0354608	SWI6	YPL120W|VPS30|S000006041|Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1
YDL198C	0.0348858	SWI6	YDL198C|GGC1|S000002357|Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family
YDR174W	0.0344348	SWI6	YDR174W|HMO1|S000002581|Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
YIL005W	0.0343091	SWI6	YIL005W|EPS1|S000001267|ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family
YGR111W	0.0342719	SWI6	YGR111W||S000003343|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YBR301W	0.0337229	SWI6	YBR301W|DAN3|S000000505|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YGR252W	0.0325527	SWI6	YGR252W|GCN5|S000003484|Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily
YDR137W	0.0323374	SWI6	YDR137W|RGP1|S000002544|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
YNL259C	0.0311894	SWI6	YNL259C|ATX1|S000005203|Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
YJL215C	0.030843	SWI6	YJL215C||S000003751|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIR006C	0.0308281	SWI6	YIR006C|PAN1|S000001445|Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease
YGR021W	0.0305765	SWI6	YGR021W||S000003253|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR161W-C	0.0305572	SWI6	YGR161W-C||S000029726|Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YLR024C	0.0295407	SWI6	YLR024C|UBR2|S000004014|Cytoplasmic ubiquitin-protein ligase (E3)
YEL016C	0.027884	SWI6	YEL016C|NPP2|S000000742|Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation
YPL045W	0.0275236	SWI6	YPL045W|VPS16|S000005966|Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
YLR376C	0.0271296	SWI6	YLR376C|PSY3|S000004368|Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
YJR135W-A	0.0266262	SWI6	YJR135W-A|TIM8|S000007348|Mitochondrial intermembrane space protein mediating import and insertion of polytopic inner membrane proteins; homolog of human DDP1 (deafness dystonia peptide 1) which is mutated in the X-linked Mohr-Tranebjaerg syndrome
YLL063C	0.0230688	SWI6	YLL063C|AYT1|S000003986|Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
YGR198W	0.0223157	SWI6	YGR198W|YPP1|S000003430|Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
YNL021W	0.0220493	SWI6	YNL021W|HDA1|S000004966|Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation
YOR032W-A	0.0216616	SWI6	YOR032W-A||S000028710|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YJR098C	0.02166	SWI6	YJR098C||S000003859|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR157C	0.0214985	SWI6	YBR157C|ICS2|S000000361|Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YBR025C	0.019777	SWI6	YBR025C|OLA1|S000000229|P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide
YCL057W	0.0196046	SWI6	YCL057W|PRD1|S000000562|Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins
YCR084C	0.0194992	SWI6	YCR084C|TUP1|S000000680|General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
YBL035C	0.0189778	SWI6	YBL035C|POL12|S000000131|B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation
YMR122C	0.0185078	SWI6	YMR122C||S000004729|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL080C	0.0180653	SWI6	YBL080C|PET112|S000000176|Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis ortholog
YNL160W	0.0179569	SWI6	YNL160W|YGP1|S000005104|Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YGL025C	0.0173121	SWI6	YGL025C|PGD1|S000002993|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
YDR081C	0.0172686	SWI6	YDR081C|PDC2|S000002488|Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes
YKR052C	0.0159306	SWI6	YKR052C|MRS4|S000001760|Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YNR071C	0.0157369	SWI6	YNR071C||S000005354|Putative protein of unknown function
YER169W	0.0156613	SWI6	YER169W|RPH1|S000000971|JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
YNR032W	0.0147378	SWI6	YNR032W|PPG1|S000005315|Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
YML070W	0.0129546	SWI6	YML070W|DAK1|S000004535|Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YIL067C	0.0124784	SWI6	YIL067C||S000001329|Uncharacterized protein of unknown function
YMR119W-A	0.011881	SWI6	YMR119W-A||S000004726|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR318W	0.0114017	SWI6	YDR318W|MCM21|S000002726|Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules
YHR124W	0.0107027	SWI6	YHR124W|NDT80|S000001166|Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YKL208W	0.0103766	SWI6	YKL208W|CBT1|S000001691|Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
YDR196C	0.00909508	SWI6	YDR196C||S000002604|Putative dephospho-CoA kinase (DPCK) that catalyzes the final step in Coenzyme A biosynthesis; essential for viability; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR058W	0.00877156	SWI6	YMR058W|FET3|S000004662|Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases
YNL003C	0.00786134	SWI6	YNL003C|PET8|S000004948|S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth
YHR014W	0.00638594	SWI6	YHR014W|SPO13|S000001056|Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
YML130C	0.00583935	SWI6	YML130C|ERO1|S000004599|Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
YIR009W	0.00533588	SWI6	YIR009W|MSL1|S000001448|U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro; does not contain the conserved C-terminal RNA binding domain found in other family members
YML041C	0.00322517	SWI6	YML041C|VPS71|S000004505|Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YDL195W	0.00120934	SWI6	YDL195W|SEC31|S000002354|Essential phosphoprotein component (p150) of the COPII coat of secretory pathway vesicles, in complex with Sec13p; required for ER-derived transport vesicle formation
YLR082C	0.000625025	SWI6	YLR082C|SRL2|S000004072|Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
YFR011C	0.000197987	SWI6	YFR011C|AIM13|S000001907|Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and reduced growth rate in minimal glycerol media
