YOR348C	6.73725	RSC30	YOR348C|PUT4|S000005875|Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YIL057C	3.51838	RSC30	YIL057C||S000001319|Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YGR067C	3.21848	RSC30	YGR067C||S000003299|Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YJR115W	2.68734	RSC30	YJR115W||S000003876|Putative protein of unknown function
YOR345C	2.68669	RSC30	YOR345C||S000005872|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YKL109W	2.68386	RSC30	YKL109W|HAP4|S000001592|Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YML089C	2.62871	RSC30	YML089C||S000004554|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YGL062W	2.57773	RSC30	YGL062W|PYC1|S000003030|Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YPL026C	2.54715	RSC30	YPL026C|SKS1|S000005947|Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YOR346W	2.5281	RSC30	YOR346W|REV1|S000005873|Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YKL031W	2.48029	RSC30	YKL031W||S000001514|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YOR072W	2.4062	RSC30	YOR072W||S000005598|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YPL024W	2.31371	RSC30	YPL024W|RMI1|S000005945|Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YAR050W	2.28504	RSC30	YAR050W|FLO1|S000000084|Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YPR036W-A	2.18473	RSC30	YPR036W-A||S000028425|Protein of unknown function; transcription is regulated by Pdr1p
YER065C	2.10174	RSC30	YER065C|ICL1|S000000867|Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YOR071C	1.99555	RSC30	YOR071C|NRT1|S000005597|High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YJL045W	1.96014	RSC30	YJL045W||S000003581|Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YER088C	1.95053	RSC30	YER088C|DOT6|S000000890|Protein of unknown function, involved in telomeric gene silencing and filamentation
YLR296W	1.91962	RSC30	YLR296W||S000004287|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR150W	1.84425	RSC30	YPR150W||S000006354|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YDL222C	1.76566	RSC30	YDL222C|FMP45|S000002381|Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YOR072W-A	1.76131	RSC30	YOR072W-A||S000028582|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YJR078W	1.74453	RSC30	YJR078W|BNA2|S000003839|Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YCR005C	1.73343	RSC30	YCR005C|CIT2|S000000598|Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YBR105C	1.70234	RSC30	YBR105C|VID24|S000000309|Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YML090W	1.69518	RSC30	YML090W||S000004555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YAR047C	1.65094	RSC30	YAR047C||S000000083|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR152C	1.638	RSC30	YOR152C||S000005678|Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YER150W	1.62785	RSC30	YER150W|SPI1|S000000952|GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YBL015W	1.62595	RSC30	YBL015W|ACH1|S000000111|Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YDR343C	1.52927	RSC30	YDR343C|HXT6|S000002751|High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YJL067W	1.51535	RSC30	YJL067W||S000003603|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR035W	1.46634	RSC30	YAR035W|YAT1|S000000080|Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YDL210W	1.44566	RSC30	YDL210W|UGA4|S000002369|Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YJR095W	1.43548	RSC30	YJR095W|SFC1|S000003856|Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YPR065W	1.43302	RSC30	YPR065W|ROX1|S000006269|Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YOR192C	1.39117	RSC30	YOR192C|THI72|S000005718|Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YMR194C-B	1.37844	RSC30	YMR194C-B||S000028514|Putative protein of unknown function
YOR120W	1.35883	RSC30	YOR120W|GCY1|S000005646|Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YLR295C	1.34969	RSC30	YLR295C|ATP14|S000004286|Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YFL030W	1.34684	RSC30	YFL030W|AGX1|S000001864|Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YML091C	1.33313	RSC30	YML091C|RPM2|S000004556|Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YBR297W	1.32226	RSC30	YBR297W|MAL33|S000000501|MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YOL084W	1.30681	RSC30	YOL084W|PHM7|S000005444|Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YLR236C	1.29233	RSC30	YLR236C||S000004226|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR033C	1.27046	RSC30	YFR033C|QCR6|S000001929|Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1
YPL230W	1.25709	RSC30	YPL230W|USV1|S000006151|Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YBR201C-A	1.24808	RSC30	YBR201C-A||S000087085|Putative protein of unknown function
YAR023C	1.24691	RSC30	YAR023C||S000000074|Putative integral membrane protein, member of DUP240 gene family
YMR103C	1.24567	RSC30	YMR103C||S000004709|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL305C	1.24539	RSC30	YNL305C||S000005249|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL305C is not an essential gene
YBL033C	1.21279	RSC30	YBL033C|RIB1|S000000129|GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YPL061W	1.19683	RSC30	YPL061W|ALD6|S000005982|Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YHR139C	1.17384	RSC30	YHR139C|SPS100|S000001181|Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YLR235C	1.1719	RSC30	YLR235C||S000004225|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YGL045W	1.16719	RSC30	YGL045W|RIM8|S000003013|Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YOL060C	1.16558	RSC30	YOL060C|MAM3|S000005421|Protein required for normal mitochondrial morphology, has similarity to hemolysins
YLR377C	1.15255	RSC30	YLR377C|FBP1|S000004369|Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YMR195W	1.1518	RSC30	YMR195W|ICY1|S000004808|Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YOR139C	1.14676	RSC30	YOR139C||S000005665|Hypothetical protein
YAL039C	1.14463	RSC30	YAL039C|CYC3|S000000037|Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YKL032C	1.11867	RSC30	YKL032C|IXR1|S000001515|Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YDR277C	1.11022	RSC30	YDR277C|MTH1|S000002685|Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YKL171W	1.10655	RSC30	YKL171W||S000001654|Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YFR029W	1.1032	RSC30	YFR029W|PTR3|S000001925|Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YIL099W	1.07977	RSC30	YIL099W|SGA1|S000001361|Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YAR070C	1.07508	RSC30	YAR070C||S000000093|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR259C	1.07243	RSC30	YDR259C|YAP6|S000002667|Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YFL024C	1.07103	RSC30	YFL024C|EPL1|S000001870|Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YPR127W	1.0698	RSC30	YPR127W||S000006331|Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YHR033W	1.06842	RSC30	YHR033W||S000001075|Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YIL125W	1.04337	RSC30	YIL125W|KGD1|S000001387|Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA
YDL067C	1.03539	RSC30	YDL067C|COX9|S000002225|Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YOR186C-A	1.02965	RSC30	YOR186C-A||S000028715|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOL085W-A	1.0121	RSC30	YOL085W-A||S000028708|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YPL250C	1.00523	RSC30	YPL250C|ICY2|S000006171|Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YDR377W	1.00307	RSC30	YDR377W|ATP17|S000002785|Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YCR025C	0.995303	RSC30	YCR025C||S000000620|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YPL262W	0.986382	RSC30	YPL262W|FUM1|S000006183|Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YMR181C	0.982655	RSC30	YMR181C||S000004793|Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YOR192C-C	0.977894	RSC30	YOR192C-C||S000028857|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YPR013C	0.972584	RSC30	YPR013C||S000006217|Putative zinc finger protein; YPR013C is not an essential gene
YNR073C	0.968497	RSC30	YNR073C||S000005356|Putative mannitol dehydrogenase
YOR140W	0.964718	RSC30	YOR140W|SFL1|S000005666|Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YBL064C	0.946073	RSC30	YBL064C|PRX1|S000000160|Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YNL091W	0.921916	RSC30	YNL091W|NST1|S000005035|Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YLR438W	0.910997	RSC30	YLR438W|CAR2|S000004430|L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YGL177W	0.884112	RSC30	YGL177W||S000003145|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR069C	0.882434	RSC30	YAR069C||S000000092|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR048W	0.873309	RSC30	YJR048W|CYC1|S000003809|Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR235W	0.860398	RSC30	YOR235W|IRC13|S000005761|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YMR306C-A	0.858191	RSC30	YMR306C-A||S000004922|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR176W	0.854805	RSC30	YHR176W|FMO1|S000001219|Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YPR192W	0.849512	RSC30	YPR192W|AQY1|S000006396|Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YDR043C	0.837952	RSC30	YDR043C|NRG1|S000002450|Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YIL101C	0.828539	RSC30	YIL101C|XBP1|S000001363|Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YKL163W	0.823323	RSC30	YKL163W|PIR3|S000001646|O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YKL085W	0.82108	RSC30	YKL085W|MDH1|S000001568|Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YLR054C	0.813087	RSC30	YLR054C|OSW2|S000004044|Protein of unknown function proposed to be involved in the assembly of the spore wall
YDR169C	0.80873	RSC30	YDR169C|STB3|S000002576|Protein that binds Sin3p in a two-hybrid assay
YHR211W	0.807881	RSC30	YHR211W|FLO5|S000001254|Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YEL049W	0.807621	RSC30	YEL049W|PAU2|S000000775|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR119W-A	0.789867	RSC30	YDR119W-A||S000113555|Putative protein of unknown function
YFL064C	0.789716	RSC30	YFL064C||S000001830|Putative protein of unknown function
YLR297W	0.788302	RSC30	YLR297W||S000004288|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YKL217W	0.78276	RSC30	YKL217W|JEN1|S000001700|Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDL181W	0.764886	RSC30	YDL181W|INH1|S000002340|Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YFR034C	0.757878	RSC30	YFR034C|PHO4|S000001930|Basic helix-loop-helix (bHLH) transcription factor of the myc-family; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability
YJR077C	0.756865	RSC30	YJR077C|MIR1|S000003838|Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YMR135C	0.753107	RSC30	YMR135C|GID8|S000004742|Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YNL033W	0.739975	RSC30	YNL033W||S000004978|Putative protein of unknown function
YLR437C-A	0.739258	RSC30	YLR437C-A||S000028684|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YOR338W	0.739062	RSC30	YOR338W||S000005865|Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YPL058C	0.723688	RSC30	YPL058C|PDR12|S000005979|Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YLR237W	0.720822	RSC30	YLR237W|THI7|S000004227|Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YIL055C	0.710673	RSC30	YIL055C||S000001317|Putative protein of unknown function
YBR240C	0.700661	RSC30	YBR240C|THI2|S000000444|Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
YCL025C	0.697625	RSC30	YCL025C|AGP1|S000000530|Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YFL059W	0.690829	RSC30	YFL059W|SNZ3|S000001835|Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3
YGR258C	0.690709	RSC30	YGR258C|RAD2|S000003490|Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YPL025C	0.690355	RSC30	YPL025C||S000005946|Hypothetical protein
YLR176C	0.689898	RSC30	YLR176C|RFX1|S000004166|Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
YMR017W	0.686942	RSC30	YMR017W|SPO20|S000004619|Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YDR242W	0.677667	RSC30	YDR242W|AMD2|S000002650|Putative amidase
YIR027C	0.677388	RSC30	YIR027C|DAL1|S000001466|Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YOR138C	0.677009	RSC30	YOR138C|RUP1|S000005664|Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; required for binding of Rsp5p to Ubp2p; contains an UBA domain
YDR452W	0.6715	RSC30	YDR452W|PPN1|S000002860|Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YPR054W	0.669926	RSC30	YPR054W|SMK1|S000006258|Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
YGL146C	0.667701	RSC30	YGL146C||S000003114|Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YDR466W	0.665366	RSC30	YDR466W|PKH3|S000002874|Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YBR284W	0.658749	RSC30	YBR284W||S000000488|Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YOR394W	0.658568	RSC30	YOR394W|PAU21|S000005921|Hypothetical protein
YHR015W	0.656836	RSC30	YHR015W|MIP6|S000001057|Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YNL104C	0.65484	RSC30	YNL104C|LEU4|S000005048|Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YGL117W	0.647183	RSC30	YGL117W||S000003085|Putative protein of unknown function
YGR121C	0.644748	RSC30	YGR121C|MEP1|S000003353|Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YIL155C	0.639735	RSC30	YIL155C|GUT2|S000001417|Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YPL015C	0.631398	RSC30	YPL015C|HST2|S000005936|Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
YOR344C	0.63061	RSC30	YOR344C|TYE7|S000005871|Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YPL164C	0.625627	RSC30	YPL164C|MLH3|S000006085|Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability
YIL100C-A	0.624537	RSC30	YIL100C-A||S000028794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR034W-A	0.62098	RSC30	YFR034W-A||S000028631|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YJL100W	0.617563	RSC30	YJL100W|LSB6|S000003636|Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YPL282C	0.61494	RSC30	YPL282C|PAU22|S000006203|Hypothetical protein
YDR231C	0.613315	RSC30	YDR231C|COX20|S000002639|Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YNL103W	0.612141	RSC30	YNL103W|MET4|S000005047|Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YBR006W	0.609019	RSC30	YBR006W|UGA2|S000000210|Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm
YNL125C	0.605613	RSC30	YNL125C|ESBP6|S000005069|Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YPL135W	0.604999	RSC30	YPL135W|ISU1|S000006056|Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YDL174C	0.600702	RSC30	YDL174C|DLD1|S000002333|D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YLR111W	0.599539	RSC30	YLR111W||S000004101|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER069W	0.589308	RSC30	YER069W|ARG5,6|S000000871|Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YHR071W	0.588721	RSC30	YHR071W|PCL5|S000001113|Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YKR097W	0.584063	RSC30	YKR097W|PCK1|S000001805|Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YDL007C-A	0.583135	RSC30	YDL007C-A||S000113557|Putative protein of unknown function
YFR012W	0.579717	RSC30	YFR012W||S000001908|Putative protein of unknown function
YDL221W	0.577026	RSC30	YDL221W||S000002380|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
YNR047W	0.57553	RSC30	YNR047W||S000005330|Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate
YNL283C	0.561484	RSC30	YNL283C|WSC2|S000005227|Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YIL045W	0.560992	RSC30	YIL045W|PIG2|S000001307|Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YJL103C	0.557433	RSC30	YJL103C|GSM1|S000003639|Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YML133C	0.556703	RSC30	YML133C||S000004602|Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
YLR399C	0.551794	RSC30	YLR399C|BDF1|S000004391|Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p
YMR069W	0.548399	RSC30	YMR069W|NAT4|S000004673|N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A
YNL019C	0.54519	RSC30	YNL019C||S000004964|Putative protein of unknown function
YPR005C	0.539589	RSC30	YPR005C|HAL1|S000006209|Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YMR063W	0.533607	RSC30	YMR063W|RIM9|S000004667|Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
YIL100W	0.53321	RSC30	YIL100W||S000001362|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YFL060C	0.527509	RSC30	YFL060C|SNO3|S000001834|Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin
YEL033W	0.525821	RSC30	YEL033W|MTC7|S000000759|Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YBR001C	0.51854	RSC30	YBR001C|NTH2|S000000205|Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses
YJL116C	0.506391	RSC30	YJL116C|NCA3|S000003652|Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YOR032C	0.49516	RSC30	YOR032C|HMS1|S000005558|Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YKR095W	0.493853	RSC30	YKR095W|MLP1|S000001803|Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
YJL005W	0.492977	RSC30	YJL005W|CYR1|S000003542|Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YHR145C	0.492216	RSC30	YHR145C||S000001188|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL243W	0.492127	RSC30	YNL243W|SLA2|S000005187|Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo
YBL084C	0.48944	RSC30	YBL084C|CDC27|S000000180|Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YER068C-A	0.488009	RSC30	YER068C-A||S000028749|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFL063W	0.487884	RSC30	YFL063W||S000001831|Dubious open reading frame, based on available experimental and comparative sequence data
YNL282W	0.485666	RSC30	YNL282W|POP3|S000005226|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YKL161C	0.477875	RSC30	YKL161C||S000001644|Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YMR306W	0.473059	RSC30	YMR306W|FKS3|S000004923|Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL028W	0.470674	RSC30	YEL028W||S000000754|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL014W	0.469464	RSC30	YNL014W|HEF3|S000004959|Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YGR144W	0.467494	RSC30	YGR144W|THI4|S000003376|Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YOR374W	0.466936	RSC30	YOR374W|ALD4|S000005901|Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YBR077C	0.463953	RSC30	YBR077C|SLM4|S000000281|Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YJL102W	0.461933	RSC30	YJL102W|MEF2|S000003638|Mitochondrial elongation factor involved in translational elongation
YBR035C	0.460786	RSC30	YBR035C|PDX3|S000000239|Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YEL009C	0.460559	RSC30	YEL009C|GCN4|S000000735|Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YNL245C	0.449175	RSC30	YNL245C|CWC25|S000005189|Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25p
YKR067W	0.439357	RSC30	YKR067W|GPT2|S000001775|Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YLR140W	0.438282	RSC30	YLR140W||S000004130|Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I
YPL054W	0.433455	RSC30	YPL054W|LEE1|S000005975|Zinc-finger protein of unknown function
YBR179C	0.43192	RSC30	YBR179C|FZO1|S000000383|Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YOR236W	0.426368	RSC30	YOR236W|DFR1|S000005762|Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
YBL100C	0.425661	RSC30	YBL100C||S000000196|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YOR285W	0.422983	RSC30	YOR285W||S000005811|Protein of unknown function, localized to the mitochondrial outer membrane
YPR026W	0.418227	RSC30	YPR026W|ATH1|S000006230|Acid trehalase required for utilization of extracellular trehalose
YDR171W	0.410547	RSC30	YDR171W|HSP42|S000002578|Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YBL045C	0.410152	RSC30	YBL045C|COR1|S000000141|Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YOR032W-A	0.406227	RSC30	YOR032W-A||S000028710|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR106W	0.401792	RSC30	YHR106W|TRR2|S000001148|Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD
YER020W	0.401769	RSC30	YER020W|GPA2|S000000822|Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YDR232W	0.396493	RSC30	YDR232W|HEM1|S000002640|5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YMR135W-A	0.393075	RSC30	YMR135W-A||S000004743|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL008W	0.393003	RSC30	YEL008W||S000000734|Hypothetical protein predicted to be involved in metabolism
YPL196W	0.389984	RSC30	YPL196W|OXR1|S000006117|Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes but not in prokaryotes
YJL084C	0.387214	RSC30	YJL084C|ALY2|S000003620|Cytoplasmic protein of unknown function that interacts with the cyclin Pcl7p; phosphorylated in vitro by the cyclin-CDK complex, Pcl7p-Pho85p; identified as a potential Cdc28p substrate; mRNA is cell cycle regulated, peaking in M phase
YMR272C	0.386561	RSC30	YMR272C|SCS7|S000004885|Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YAR068W	0.384971	RSC30	YAR068W||S000000091|Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YJL068C	0.383361	RSC30	YJL068C||S000003604|Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YCR063W	0.382847	RSC30	YCR063W|BUD31|S000000659|Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YDR275W	0.380819	RSC30	YDR275W|BSC2|S000002683|Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YOR343C	0.38047	RSC30	YOR343C||S000005870|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDR077W	0.375339	RSC30	YDR077W|SED1|S000002484|Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YER056C	0.375254	RSC30	YER056C|FCY2|S000000858|Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation
YIL113W	0.36873	RSC30	YIL113W|SDP1|S000001375|Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YBR019C	0.364284	RSC30	YBR019C|GAL10|S000000223|UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YEL071W	0.362304	RSC30	YEL071W|DLD3|S000000797|D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
YCL012C	0.35092	RSC30	YCL012C||S000029705|Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene
YBR180W	0.3502	RSC30	YBR180W|DTR1|S000000384|Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YOR298C-A	0.348499	RSC30	YOR298C-A|MBF1|S000007253|Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations
YFL023W	0.331373	RSC30	YFL023W|BUD27|S000001871|Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition
YIR028W	0.330193	RSC30	YIR028W|DAL4|S000001467|Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YBR235W	0.329197	RSC30	YBR235W||S000000439|Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
YKL160W	0.328407	RSC30	YKL160W|ELF1|S000001643|Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
YNL339C	0.327023	RSC30	YNL339C|YRF1-6|S000005283|Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YCR046C	0.324134	RSC30	YCR046C|IMG1|S000000642|Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
YHR146W	0.324122	RSC30	YHR146W|CRP1|S000001189|Protein that binds to cruciform DNA structures
YDR247W	0.320183	RSC30	YDR247W|VHS1|S000002655|Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p
YLR122C	0.318245	RSC30	YLR122C||S000004112|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YER158C	0.315132	RSC30	YER158C||S000000960|Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YKL084W	0.313907	RSC30	YKL084W|HOT13|S000001567|Mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex
YBR230C	0.31138	RSC30	YBR230C|OM14|S000000434|Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YDR216W	0.305452	RSC30	YDR216W|ADR1|S000002624|Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YML131W	0.303759	RSC30	YML131W||S000004600|Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YDR039C	0.303436	RSC30	YDR039C|ENA2|S000002446|P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux
YGL056C	0.302985	RSC30	YGL056C|SDS23|S000003024|One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YLR390W	0.3022	RSC30	YLR390W|ECM19|S000004382|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL050C	0.298794	RSC30	YEL050C|RML2|S000000776|Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YBL099W	0.298413	RSC30	YBL099W|ATP1|S000000195|Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YNL164C	0.297198	RSC30	YNL164C|IBD2|S000005108|Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p
YIR011C	0.295622	RSC30	YIR011C|STS1|S000001450|Protein that interacts with the karyopherin Srp1p; may have a role with Srp1p in ubiquitin-mediated protein degradation
YBL030C	0.293553	RSC30	YBL030C|PET9|S000000126|Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YDR036C	0.287494	RSC30	YDR036C|EHD3|S000002443|3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YGL163C	0.286447	RSC30	YGL163C|RAD54|S000003131|DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YEL006W	0.285443	RSC30	YEL006W|YEA6|S000000732|Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
YEL044W	0.282239	RSC30	YEL044W|IES6|S000000770|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YML032C	0.279747	RSC30	YML032C|RAD52|S000004494|Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis
YEL007W	0.275818	RSC30	YEL007W||S000000733|Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YLR123C	0.274682	RSC30	YLR123C||S000004113|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLL060C	0.271987	RSC30	YLL060C|GTT2|S000003983|Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YKL071W	0.267524	RSC30	YKL071W||S000001554|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR020W	0.266139	RSC30	YBR020W|GAL1|S000000224|Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p
YOL078W	0.265934	RSC30	YOL078W|AVO1|S000005438|Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YBR033W	0.261964	RSC30	YBR033W|EDS1|S000000237|Putative zinc cluster protein; YBR033W is not an essential gene
YGR260W	0.260394	RSC30	YGR260W|TNA1|S000003492|High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YJL130C	0.259696	RSC30	YJL130C|URA2|S000003666|Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YLR356W	0.257992	RSC30	YLR356W||S000004348|Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YDR389W	0.255213	RSC30	YDR389W|SAC7|S000002797|GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
YGL166W	0.25044	RSC30	YGL166W|CUP2|S000003134|Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations
YIL006W	0.245858	RSC30	YIL006W|YIA6|S000001268|Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs
YDR042C	0.244396	RSC30	YDR042C||S000002449|Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YNL244C	0.240549	RSC30	YNL244C|SUI1|S000005188|Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase
YDR255C	0.239497	RSC30	YDR255C|RMD5|S000002663|Cytosolic protein required for sporulation; also required for the ubiquitination of the gluconeogenetic enzyme fructose-1,6-bisphosphatase, which is degraded rapidly after the switch from gluconeogenesis to glycolysis
YIL136W	0.237287	RSC30	YIL136W|OM45|S000001398|Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YNL180C	0.234984	RSC30	YNL180C|RHO5|S000005124|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YNL054W	0.233753	RSC30	YNL054W|VAC7|S000004999|Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock
YMR168C	0.23174	RSC30	YMR168C|CEP3|S000004778|Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
YBL042C	0.229848	RSC30	YBL042C|FUI1|S000000138|High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport
YDR420W	0.227759	RSC30	YDR420W|HKR1|S000002828|Serine/threonine rich cell surface protein; osmosensor; involved in the regulation of cell wall beta-1,3 glucan synthesis, bud site selection and hyperosmotic response; overexpression confers resistance to Hansenula mrakii killer toxin HM-1
YOR065W	0.225086	RSC30	YOR065W|CYT1|S000005591|Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YLR124W	0.225008	RSC30	YLR124W||S000004114|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL156C	0.224998	RSC30	YNL156C|NSG2|S000005100|Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
YNL179C	0.224634	RSC30	YNL179C||S000005123|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YHR093W	0.223968	RSC30	YHR093W|AHT1|S000001135|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YFR026C	0.221349	RSC30	YFR026C||S000001922|Putative protein of unknown function
YKL095W	0.218436	RSC30	YKL095W|YJU2|S000001578|Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ("nineteen complex") and acts after Prp2p to promote the first catalytic reaction of splicing
YMR056C	0.217923	RSC30	YMR056C|AAC1|S000004660|Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YGL072C	0.214741	RSC30	YGL072C||S000003040|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YER010C	0.212908	RSC30	YER010C||S000000812|Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YLR402W	0.211588	RSC30	YLR402W||S000004394|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR178C	0.21101	RSC30	YOR178C|GAC1|S000005704|Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YOR173W	0.210148	RSC30	YOR173W|DCS2|S000005699|Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YFL062W	0.207726	RSC30	YFL062W|COS4|S000001832|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGL197W	0.200252	RSC30	YGL197W|MDS3|S000003165|Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions
YOR211C	0.196796	RSC30	YOR211C|MGM1|S000005737|Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YEL045C	0.19549	RSC30	YEL045C||S000000771|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YOR290C	0.194175	RSC30	YOR290C|SNF2|S000005816|Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
YGR259C	0.192297	RSC30	YGR259C||S000003491|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YLL056C	0.190125	RSC30	YLL056C||S000003979|Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YLR403W	0.189865	RSC30	YLR403W|SFP1|S000004395|Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YLR008C	0.189752	RSC30	YLR008C|PAM18|S000003998|J-protein co-chaperone of the mitochondrial import motor associated with the presequence translocase, with Ssc1p, Tim44p, Mge1p, and Pam16p; stimulates ATPase activity of Ssc1p to drive mitochondrial import; activity is inhibited by Pam16p
YNL144C	0.189536	RSC30	YNL144C||S000005088|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YER004W	0.189273	RSC30	YER004W|FMP52|S000000806|Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YOR113W	0.188855	RSC30	YOR113W|AZF1|S000005639|Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance
YMR030W	0.187956	RSC30	YMR030W|RSF1|S000004632|Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth
YLR407W	0.186987	RSC30	YLR407W||S000004399|Putative protein of unknown function; YLR407W is not an essential gene
YFL019C	0.179296	RSC30	YFL019C||S000001875|Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YNR036C	0.175991	RSC30	YNR036C||S000005319|Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins
YER111C	0.175568	RSC30	YER111C|SWI4|S000000913|DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YPR184W	0.174219	RSC30	YPR184W|GDB1|S000006388|Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YKR073C	0.173541	RSC30	YKR073C||S000001781|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFR027W	0.172799	RSC30	YFR027W|ECO1|S000001923|Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication and in response to double-strand breaks; also required for postreplicative double-strand break repair
YIL126W	0.172056	RSC30	YIL126W|STH1|S000001388|ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YPR117W	0.170946	RSC30	YPR117W||S000006321|Putative protein of unknown function
YKR066C	0.17064	RSC30	YKR066C|CCP1|S000001774|Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress
YGR022C	0.169477	RSC30	YGR022C||S000003254|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YMR068W	0.167321	RSC30	YMR068W|AVO2|S000004672|Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YGL156W	0.164813	RSC30	YGL156W|AMS1|S000003124|Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YGL149W	0.16284	RSC30	YGL149W||S000003117|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
YLL019C	0.162752	RSC30	YLL019C|KNS1|S000003942|Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YJL101C	0.162162	RSC30	YJL101C|GSH1|S000003637|Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
YFL021W	0.160807	RSC30	YFL021W|GAT1|S000001873|Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YMR279C	0.159381	RSC30	YMR279C||S000004892|Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YDL173W	0.156194	RSC30	YDL173W||S000002332|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene
YGR019W	0.155145	RSC30	YGR019W|UGA1|S000003251|Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization
YLR125W	0.154984	RSC30	YLR125W||S000004115|Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YGR023W	0.1549	RSC30	YGR023W|MTL1|S000003255|Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YLR378C	0.154891	RSC30	YLR378C|SEC61|S000004370|Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
YKL187C	0.153406	RSC30	YKL187C||S000001670|Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
YMR016C	0.15304	RSC30	YMR016C|SOK2|S000004618|Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YPR018W	0.15038	RSC30	YPR018W|RLF2|S000006222|Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
YBR218C	0.149139	RSC30	YBR218C|PYC2|S000000422|Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YCR021C	0.147461	RSC30	YCR021C|HSP30|S000000615|Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YJL083W	0.144414	RSC30	YJL083W|TAX4|S000003619|EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS
YDR312W	0.144022	RSC30	YDR312W|SSF2|S000002720|Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family
YNL134C	0.143074	RSC30	YNL134C||S000005078|Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YLR379W	0.142673	RSC30	YLR379W||S000004371|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C
YKL046C	0.142506	RSC30	YKL046C|DCW1|S000001529|Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p
YNL071W	0.140913	RSC30	YNL071W|LAT1|S000005015|Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
YHR210C	0.140073	RSC30	YHR210C||S000001253|Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YKL186C	0.138715	RSC30	YKL186C|MTR2|S000001669|mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
YLR095C	0.134008	RSC30	YLR095C|IOC2|S000004085|Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
YGL185C	0.133095	RSC30	YGL185C||S000003153|Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR214W	0.129838	RSC30	YBR214W|SDS24|S000000418|One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YFL020C	0.129525	RSC30	YFL020C|PAU5|S000001874|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YBR280C	0.12893	RSC30	YBR280C|SAF1|S000000484|F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YNL094W	0.127287	RSC30	YNL094W|APP1|S000005038|Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
YEL039C	0.126171	RSC30	YEL039C|CYC7|S000000765|Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YHR139C-A	0.123145	RSC30	YHR139C-A||S000003533|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR072C	0.122571	RSC30	YKR072C|SIS2|S000001780|Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression
YEL072W	0.122394	RSC30	YEL072W|RMD6|S000000798|Protein required for sporulation
YGL071W	0.122341	RSC30	YGL071W|AFT1|S000003039|Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
YMR244C-A	0.121197	RSC30	YMR244C-A||S000004857|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
YCR061W	0.120738	RSC30	YCR061W||S000000657|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation
YKR076W	0.119954	RSC30	YKR076W|ECM4|S000001784|Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBL086C	0.119657	RSC30	YBL086C||S000000182|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YMR304W	0.119568	RSC30	YMR304W|UBP15|S000004920|Ubiquitin-specific protease that may play a role in ubiquitin precursor processing
YGL035C	0.119022	RSC30	YGL035C|MIG1|S000003003|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YNL095C	0.118439	RSC30	YNL095C||S000005039|Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene
YDL244W	0.118265	RSC30	YDL244W|THI13|S000002403|Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YPL067C	0.117994	RSC30	YPL067C||S000005988|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
YKR042W	0.117603	RSC30	YKR042W|UTH1|S000001750|Mitochondrial outer membrane and cell wall localized SUN family member required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, mitochondrial biogenesis, and cell death
YIL007C	0.117454	RSC30	YIL007C|NAS2|S000001269|Protein with similarity to the p27 subunit of mammalian proteasome modulator; not essential; interacts with Rpn4p
YMR086W	0.117277	RSC30	YMR086W||S000004692|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; cAMP represses YMR086W expression
YKL198C	0.113294	RSC30	YKL198C|PTK1|S000001681|Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
YPR064W	0.112071	RSC30	YPR064W||S000006268|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YIL150C	0.110651	RSC30	YIL150C|MCM10|S000001412|Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins
YJR151C	0.108601	RSC30	YJR151C|DAN4|S000003912|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YHR080C	0.107878	RSC30	YHR080C||S000001122|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR187W	0.107586	RSC30	YLR187W|SKG3|S000004177|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p
YDR136C	0.106104	RSC30	YDR136C|VPS61|S000002543|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
YGL227W	0.105469	RSC30	YGL227W|VID30|S000003196|Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm
YDL066W	0.105458	RSC30	YDL066W|IDP1|S000002224|Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YHR050W	0.105373	RSC30	YHR050W|SMF2|S000001092|Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YGL104C	0.105035	RSC30	YGL104C|VPS73|S000003072|Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YGL150C	0.105029	RSC30	YGL150C|INO80|S000003118|ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases
YML061C	0.103635	RSC30	YML061C|PIF1|S000004526|DNA helicase involved in telomere formation and elongation; acts as a catalytic inhibitor of telomerase; also plays a role in repair and recombination of mitochondrial DNA
YCL005W	0.103111	RSC30	YCL005W|LDB16|S000000511|Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
YLR055C	0.101265	RSC30	YLR055C|SPT8|S000004045|Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
YIR018W	0.101109	RSC30	YIR018W|YAP5|S000001457|Basic leucine zipper (bZIP) transcription factor
YMR105C	0.10102	RSC30	YMR105C|PGM2|S000004711|Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YLR228C	0.100669	RSC30	YLR228C|ECM22|S000004218|Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YDR481C	0.100424	RSC30	YDR481C|PHO8|S000002889|Repressible alkaline phosphatase, a glycoprotein localized to the vacuole; regulated by levels of inorganic phosphate and by a system consisting of Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides
YBR230W-A	0.100319	RSC30	YBR230W-A||S000029722|Putative protein of unknown function
YOR084W	0.100168	RSC30	YOR084W|LPX1|S000005610|Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
YPR017C	0.0987504	RSC30	YPR017C|DSS4|S000006221|Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YLL055W	0.0979723	RSC30	YLL055W|YCT1|S000003978|High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YHR075C	0.0978446	RSC30	YHR075C|PPE1|S000001117|Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein
YDL058W	0.0967546	RSC30	YDL058W|USO1|S000002216|Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex
YNR017W	0.0965763	RSC30	YNR017W|TIM23|S000005300|Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
YPL219W	0.0940721	RSC30	YPL219W|PCL8|S000006140|Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
YGL033W	0.094015	RSC30	YGL033W|HOP2|S000003001|Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YPR196W	0.0938242	RSC30	YPR196W||S000006400|Putative maltose activator
YMR057C	0.0937444	RSC30	YMR057C||S000004661|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1
YNL142W	0.0927405	RSC30	YNL142W|MEP2|S000005086|Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YNL143C	0.0921666	RSC30	YNL143C||S000005087|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL127C	0.0911429	RSC30	YPL127C|HHO1|S000006048|Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation
YKR049C	0.0906824	RSC30	YKR049C|FMP46|S000001757|Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL160W	0.0878609	RSC30	YOL160W||S000005520|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL196W	0.0871366	RSC30	YDL196W||S000002355|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YOR246C	0.0870075	RSC30	YOR246C||S000005772|Protein with similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YHR049C-A	0.086875	RSC30	YHR049C-A||S000003532|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL124W	0.0860705	RSC30	YNL124W|NAF1|S000005068|Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins
YPR120C	0.0838515	RSC30	YPR120C|CLB5|S000006324|B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YPR125W	0.0835203	RSC30	YPR125W|YLH47|S000006329|Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
YDL245C	0.0829554	RSC30	YDL245C|HXT15|S000002404|Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YCR064C	0.0827739	RSC30	YCR064C||S000000660|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
YML054C	0.082735	RSC30	YML054C|CYB2|S000004518|Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YER158W-A	0.0827319	RSC30	YER158W-A||S000028624|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YPL048W	0.0826598	RSC30	YPL048W|CAM1|S000005969|Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
YML031C-A	0.0825725	RSC30	YML031C-A||S000028809|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS
YOR064C	0.0806917	RSC30	YOR064C|YNG1|S000005590|Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1
YLR369W	0.0803309	RSC30	YLR369W|SSQ1|S000004361|Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia
YML100W	0.0801526	RSC30	YML100W|TSL1|S000004566|Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function
YLR010C	0.0789401	RSC30	YLR010C|TEN1|S000004000|Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YLR037C	0.078061	RSC30	YLR037C|DAN2|S000004027|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YMR284W	0.0778079	RSC30	YMR284W|YKU70|S000004897|Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YDL197C	0.076881	RSC30	YDL197C|ASF2|S000002356|Anti-silencing protein that causes derepression of silent loci when overexpressed
YMR297W	0.0768278	RSC30	YMR297W|PRC1|S000004912|Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YOR291W	0.0766138	RSC30	YOR291W||S000005817|Putative protein of unknown function; shares sequence similarity with the type V P-type ATPase Spf1p; YOR291W is not an essential protein
YDR007W	0.0764378	RSC30	YDR007W|TRP1|S000002414|Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YBR157C	0.0734954	RSC30	YBR157C|ICS2|S000000361|Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YIR017C	0.0723978	RSC30	YIR017C|MET28|S000001456|Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
YBL103C	0.0706703	RSC30	YBL103C|RTG3|S000000199|Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
YGL167C	0.069638	RSC30	YGL167C|PMR1|S000003135|High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
YDL059C	0.0690703	RSC30	YDL059C|RAD59|S000002217|Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
YLL059C	0.0685461	RSC30	YLL059C||S000003982|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL079C	0.0683355	RSC30	YDL079C|MRK1|S000002237|Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YCL007C	0.067423	RSC30	YCL007C||S000000513|Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A
YIR014W	0.0663207	RSC30	YIR014W||S000001453|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
YEL046C	0.0658864	RSC30	YEL046C|GLY1|S000000772|Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YJR153W	0.0639648	RSC30	YJR153W|PGU1|S000003914|Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins
YGL036W	0.0632504	RSC30	YGL036W||S000003004|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene
YHL024W	0.0606093	RSC30	YHL024W|RIM4|S000001016|Putative RNA-binding protein required for the expression of early and middle sporulation genes
YML058W	0.0594221	RSC30	YML058W|SML1|S000004523|Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YFR053C	0.058751	RSC30	YFR053C|HXK1|S000001949|Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YBR148W	0.0586763	RSC30	YBR148W|YSW1|S000000352|Protein expressed specifically in spores
YPR115W	0.0581702	RSC30	YPR115W|GCA1|S000006319|Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YNL122C	0.0580946	RSC30	YNL122C||S000005066|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
YBL102W	0.057859	RSC30	YBL102W|SFT2|S000000198|Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YDR006C	0.0566487	RSC30	YDR006C|SOK1|S000002413|Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
YPR072W	0.0563022	RSC30	YPR072W|NOT5|S000006276|Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation
YER053C	0.055016	RSC30	YER053C|PIC2|S000000855|Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YNL181W	0.0517433	RSC30	YNL181W||S000005125|Putative oxidoreductase; required for cell viability
YGL255W	0.051722	RSC30	YGL255W|ZRT1|S000003224|High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YER066W	0.0512576	RSC30	YER066W||S000000868|Putative protein of unknown function; YER066W is not an essential gene
YPL055C	0.0489497	RSC30	YPL055C|LGE1|S000005976|Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
YEL060C	0.0475187	RSC30	YEL060C|PRB1|S000000786|Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YFR014C	0.0471338	RSC30	YFR014C|CMK1|S000001910|Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
YHR175W	0.0458885	RSC30	YHR175W|CTR2|S000001218|Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation
YJR059W	0.0443783	RSC30	YJR059W|PTK2|S000003820|Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake
YDL207W	0.0409859	RSC30	YDL207W|GLE1|S000002366|Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal
YJL174W	0.0403859	RSC30	YJL174W|KRE9|S000003710|Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
YLR139C	0.0378459	RSC30	YLR139C|SLS1|S000004129|Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery
YJL175W	0.0371033	RSC30	YJL175W||S000003711|Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
YFR008W	0.0351983	RSC30	YFR008W|FAR7|S000001904|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p
YHR042W	0.0349377	RSC30	YHR042W|NCP1|S000001084|NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
YML031W	0.0348504	RSC30	YML031W|NDC1|S000004493|Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II
YCR097W-A	0.0348219	RSC30	YCR097W-A||S000007632|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein
YOR304W	0.0315071	RSC30	YOR304W|ISW2|S000005831|Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
YPR022C	0.0314343	RSC30	YPR022C||S000006226|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
YML054C-A	0.030591	RSC30	YML054C-A||S000028573|Putative protein of unknown function
YHR177W	0.0302328	RSC30	YHR177W||S000001220|Putative protein of unknown function
YML101C	0.0298769	RSC30	YML101C|CUE4|S000004568|Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination
YNR004W	0.0297721	RSC30	YNR004W||S000005287|Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C
YLR400W	0.0294137	RSC30	YLR400W||S000004392|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR195C	0.0293628	RSC30	YPR195C||S000006399|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER169W	0.0290347	RSC30	YER169W|RPH1|S000000971|JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
YPR138C	0.0284678	RSC30	YPR138C|MEP3|S000006342|Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
YNL335W	0.02787	RSC30	YNL335W|DDI3|S000005279|Hypothetical protein
YOR316C-A	0.0278356	RSC30	YOR316C-A||S000028584|Putative protein of unknown function; identified by fungal homology and RT-PCR
YJR018W	0.0276534	RSC30	YJR018W||S000003779|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR306C	0.0266024	RSC30	YOR306C|MCH5|S000005833|Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
YDR207C	0.0243059	RSC30	YDR207C|UME6|S000002615|Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
YER058W	0.0232889	RSC30	YER058W|PET117|S000000860|Protein required for assembly of cytochrome c oxidase
YJR017C	0.0224531	RSC30	YJR017C|ESS1|S000003778|Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain
YOL148C	0.0222347	RSC30	YOL148C|SPT20|S000005508|Subunit of the SAGA transcriptional regulatory complex, involved in maintaining the integrity of the complex
YPL161C	0.0215555	RSC30	YPL161C|BEM4|S000006082|Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length
YPL049C	0.0208213	RSC30	YPL049C|DIG1|S000005970|Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YKR050W	0.0199271	RSC30	YKR050W|TRK2|S000001758|Component of the Trk1p-Trk2p potassium transport system
YDR229W	0.0198544	RSC30	YDR229W|IVY1|S000002637|Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
YBL005W	0.018624	RSC30	YBL005W|PDR3|S000000101|Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)
YOR301W	0.0183136	RSC30	YOR301W|RAX1|S000005827|Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
YLR401C	0.017754	RSC30	YLR401C|DUS3|S000004393|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YJL210W	0.0165292	RSC30	YJL210W|PEX2|S000003746|RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
YGR049W	0.0162652	RSC30	YGR049W|SCM4|S000003281|Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
YJL176C	0.0147362	RSC30	YJL176C|SWI3|S000003712|Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
YBR054W	0.0143113	RSC30	YBR054W|YRO2|S000000258|Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YOR187W	0.013727	RSC30	YOR187W|TUF1|S000005713|Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans
YPL126W	0.0135358	RSC30	YPL126W|NAN1|S000006047|U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA
YGR233C	0.0105274	RSC30	YGR233C|PHO81|S000003465|Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p
YNL155W	0.00966612	RSC30	YNL155W||S000005099|Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site
YJL117W	0.00856854	RSC30	YJL117W|PHO86|S000003653|Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles
YER112W	0.0075782	RSC30	YER112W|LSM4|S000000914|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YJL211C	0.00632564	RSC30	YJL211C||S000003747|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
YML100W-A	0.00533632	RSC30	YML100W-A||S000028688|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YER075C	0.0052971	RSC30	YER075C|PTP3|S000000877|Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
YDR057W	0.00385091	RSC30	YDR057W|YOS9|S000002464|ER quality-control lectin; integral subunit of the HRD ligase; serves as a receptor for misfolded N-glycosylated proteins, participates in their targeting to ERAD; member of the OS-9 protein family
YLR121C	0.00213534	RSC30	YLR121C|YPS3|S000004111|Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YMR070W	0.00117733	RSC30	YMR070W|MOT3|S000004674|Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes
YPR121W	0.000927114	RSC30	YPR121W|THI22|S000006325|Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YLR141W	2.31816e-05	RSC30	YLR141W|RRN5|S000004131|Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p
