YFR055W	35.4879	PBF2	YFR055W|IRC7|S000001952|Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C	30.5187	PBF2	YFR056C||S000001951|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YKR092C	24.8261	PBF2	YKR092C|SRP40|S000001800|Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YER074W	18.7232	PBF2	YER074W|RPS24A|S000000876|Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YER073W	18.371	PBF2	YER073W|ALD5|S000000875|Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YOR101W	17.221	PBF2	YOR101W|RAS1|S000005627|GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YOR096W	16.4272	PBF2	YOR096W|RPS7A|S000005622|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YPR148C	15.1086	PBF2	YPR148C||S000006352|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL178W	14.8946	PBF2	YNL178W|RPS3|S000005122|Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YIR021W	14.0811	PBF2	YIR021W|MRS1|S000001460|Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YMR246W	13.0415	PBF2	YMR246W|FAA4|S000004860|Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YDL055C	12.854	PBF2	YDL055C|PSA1|S000002213|GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YOR340C	12.6987	PBF2	YOR340C|RPA43|S000005867|RNA polymerase I subunit A43
YLR062C	12.44	PBF2	YLR062C|BUD28|S000004052|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YHR128W	12.3068	PBF2	YHR128W|FUR1|S000001170|Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YDL208W	12.0089	PBF2	YDL208W|NHP2|S000002367|Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YGR251W	11.9565	PBF2	YGR251W||S000003483|Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YER137C	11.9011	PBF2	YER137C||S000000939|Putative protein of unknown function
YER146W	11.4885	PBF2	YER146W|LSM5|S000000948|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YDL148C	11.395	PBF2	YDL148C|NOP14|S000002307|Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YPL211W	11.3541	PBF2	YPL211W|NIP7|S000006132|Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
YOL086C	11.2563	PBF2	YOL086C|ADH1|S000005446|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YOL077C	10.881	PBF2	YOL077C|BRX1|S000005437|Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
YOL127W	10.6813	PBF2	YOL127W|RPL25|S000005487|Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YLR432W	10.6443	PBF2	YLR432W|IMD3|S000004424|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YNL112W	10.5685	PBF2	YNL112W|DBP2|S000005056|Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
YML123C	10.4726	PBF2	YML123C|PHO84|S000004592|High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YNL248C	10.3933	PBF2	YNL248C|RPA49|S000005192|RNA polymerase I subunit A49
YJL010C	10.1388	PBF2	YJL010C|NOP9|S000003547|Essential component of pre-40S ribosomes that is required for early cleavages of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats
YBR154C	9.70422	PBF2	YBR154C|RPB5|S000000358|RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YMR290C	9.63266	PBF2	YMR290C|HAS1|S000004903|ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDL051W	9.58333	PBF2	YDL051W|LHP1|S000002209|RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YOR272W	9.54012	PBF2	YOR272W|YTM1|S000005798|Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YGR128C	9.51427	PBF2	YGR128C|UTP8|S000003360|Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YMR290W-A	9.49928	PBF2	YMR290W-A||S000004904|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YJL122W	9.46646	PBF2	YJL122W|ALB1|S000003658|Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YBL027W	9.35484	PBF2	YBL027W|RPL19B|S000000123|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YLR355C	9.30841	PBF2	YLR355C|ILV5|S000004347|Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YKL081W	9.27066	PBF2	YKL081W|TEF4|S000001564|Translation elongation factor EF-1 gamma
YBL039C	9.20927	PBF2	YBL039C|URA7|S000000135|Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YNL141W	9.11961	PBF2	YNL141W|AAH1|S000005085|Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YLR154C	9.11161	PBF2	YLR154C|RNH203|S000004144|Ribonuclease H2 subunit, required for RNase H2 activity
YEL053W-A	9.02764	PBF2	YEL053W-A||S000028744|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YBL028C	8.99922	PBF2	YBL028C||S000000124|Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YGL055W	8.74435	PBF2	YGL055W|OLE1|S000003023|Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YNL113W	8.74278	PBF2	YNL113W|RPC19|S000005057|RNA polymerase subunit, common to RNA polymerases I and III
YFR054C	8.74221	PBF2	YFR054C||S000001950|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR093W	8.68875	PBF2	YKR093W|PTR2|S000001801|Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YMR217W	8.68325	PBF2	YMR217W|GUA1|S000004830|GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YIL091C	8.61321	PBF2	YIL091C||S000001353|Protein required for cell viability
YPL143W	8.59117	PBF2	YPL143W|RPL33A|S000006064|N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YKL164C	8.58582	PBF2	YKL164C|PIR1|S000001647|O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YIL118W	8.56401	PBF2	YIL118W|RHO3|S000001380|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YML121W	8.55309	PBF2	YML121W|GTR1|S000004590|Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YLR449W	8.55153	PBF2	YLR449W|FPR4|S000004441|Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YPR010C	8.45824	PBF2	YPR010C|RPA135|S000006214|RNA polymerase I subunit A135
YPL250W-A	8.30064	PBF2	YPL250W-A||S000028589|Identified by fungal homology and RT-PCR
YKR081C	8.28288	PBF2	YKR081C|RPF2|S000001789|Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YGR151C	8.24243	PBF2	YGR151C||S000003383|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YLR154W-A	8.00513	PBF2	YLR154W-A||S000028675|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YMR131C	7.99682	PBF2	YMR131C|RRB1|S000004738|Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YLR009W	7.9592	PBF2	YLR009W|RLP24|S000003999|Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
YJR070C	7.9335	PBF2	YJR070C|LIA1|S000003831|Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YPL090C	7.80421	PBF2	YPL090C|RPS6A|S000006011|Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YLR154W-B	7.76852	PBF2	YLR154W-B||S000028563|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YKL009W	7.75813	PBF2	YKL009W|MRT4|S000001492|Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YOR271C	7.74193	PBF2	YOR271C|FSF1|S000005797|Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YLR075W	7.72636	PBF2	YLR075W|RPL10|S000004065|Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YML043C	7.65521	PBF2	YML043C|RRN11|S000004507|Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YMR049C	7.60181	PBF2	YMR049C|ERB1|S000004652|Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YHR066W	7.58776	PBF2	YHR066W|SSF1|S000001108|Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
YNL175C	7.55687	PBF2	YNL175C|NOP13|S000005119|Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YOR004W	7.48581	PBF2	YOR004W|UTP23|S000005530|Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YJR071W	7.45253	PBF2	YJR071W||S000003832|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL212C	7.45045	PBF2	YPL212C|PUS1|S000006133|tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
YDL022C-A	7.35007	PBF2	YDL022C-A||S000028537|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YDL112W	7.33102	PBF2	YDL112W|TRM3|S000002270|2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YDL023C	7.29928	PBF2	YDL023C||S000002181|Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YKL096W-A	7.20833	PBF2	YKL096W-A|CWP2|S000001956|Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YLR068W	7.20707	PBF2	YLR068W|FYV7|S000004058|Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
YIR026C	7.19819	PBF2	YIR026C|YVH1|S000001465|Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases
YDL014W	7.16789	PBF2	YDL014W|NOP1|S000002172|Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YNR053C	7.1673	PBF2	YNR053C|NOG2|S000005336|Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YAL059W	7.0986	PBF2	YAL059W|ECM1|S000000055|Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YLR406C	7.00645	PBF2	YLR406C|RPL31B|S000004398|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YDR087C	6.98147	PBF2	YDR087C|RRP1|S000002494|Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YLR349W	6.95423	PBF2	YLR349W||S000004341|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YJL148W	6.9504	PBF2	YJL148W|RPA34|S000003684|RNA polymerase I subunit A34.5
YGL029W	6.94237	PBF2	YGL029W|CGR1|S000002997|Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YPL093W	6.90773	PBF2	YPL093W|NOG1|S000006014|Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
YDR399W	6.89512	PBF2	YDR399W|HPT1|S000002807|Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YPR163C	6.8695	PBF2	YPR163C|TIF3|S000006367|Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YFR001W	6.71868	PBF2	YFR001W|LOC1|S000001897|Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YLR348C	6.69178	PBF2	YLR348C|DIC1|S000004340|Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YOL041C	6.64436	PBF2	YOL041C|NOP12|S000005401|Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
YHR148W	6.60023	PBF2	YHR148W|IMP3|S000001191|Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YDR465C	6.59698	PBF2	YDR465C|RMT2|S000002873|Arginine methyltransferase; ribosomal protein L12 is a substrate
YGL078C	6.59345	PBF2	YGL078C|DBP3|S000003046|Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YDL150W	6.57816	PBF2	YDL150W|RPC53|S000002309|RNA polymerase III subunit C53
YGR280C	6.53184	PBF2	YGR280C|PXR1|S000003512|Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YGR155W	6.42828	PBF2	YGR155W|CYS4|S000003387|Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YCR018C	6.4228	PBF2	YCR018C|SRD1|S000000611|Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YOL076W	6.42083	PBF2	YOL076W|MDM20|S000005436|Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly
YOR108W	6.41778	PBF2	YOR108W|LEU9|S000005634|Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YOR153W	6.4161	PBF2	YOR153W|PDR5|S000005679|Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YDR385W	6.36572	PBF2	YDR385W|EFT2|S000002793|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YKL172W	6.35459	PBF2	YKL172W|EBP2|S000001655|Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles
YPL108W	6.34608	PBF2	YPL108W||S000006029|Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YOR310C	6.29776	PBF2	YOR310C|NOP58|S000005837|Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YGR214W	6.29354	PBF2	YGR214W|RPS0A|S000003446|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YGR159C	6.24486	PBF2	YGR159C|NSR1|S000003391|Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YGR123C	6.24455	PBF2	YGR123C|PPT1|S000003355|Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YER102W	6.19745	PBF2	YER102W|RPS8B|S000000904|Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YLR196W	6.18397	PBF2	YLR196W|PWP1|S000004186|Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YGL120C	6.17657	PBF2	YGL120C|PRP43|S000003088|RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YKR024C	6.16525	PBF2	YKR024C|DBP7|S000001732|Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YOL080C	6.11346	PBF2	YOL080C|REX4|S000005440|Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YDR060W	6.06817	PBF2	YDR060W|MAK21|S000002467|Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YDL022W	6.06124	PBF2	YDL022W|GPD1|S000002180|NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YGR108W	6.03718	PBF2	YGR108W|CLB1|S000003340|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGR245C	6.01692	PBF2	YGR245C|SDA1|S000003477|Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YCL059C	5.99431	PBF2	YCL059C|KRR1|S000000564|Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
YGR145W	5.98516	PBF2	YGR145W|ENP2|S000003377|Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YAL025C	5.97508	PBF2	YAL025C|MAK16|S000000023|Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YLR409C	5.95548	PBF2	YLR409C|UTP21|S000004401|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLL008W	5.95352	PBF2	YLL008W|DRS1|S000003931|Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YBR249C	5.93286	PBF2	YBR249C|ARO4|S000000453|3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YLR180W	5.91165	PBF2	YLR180W|SAM1|S000004170|S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YFL015W-A	5.91004	PBF2	YFL015W-A||S000028765|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL079W	5.89035	PBF2	YOL079W||S000005439|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJL050W	5.86789	PBF2	YJL050W|MTR4|S000003586|Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA
YBR142W	5.86014	PBF2	YBR142W|MAK5|S000000346|Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YHR089C	5.81149	PBF2	YHR089C|GAR1|S000001131|Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YDR120C	5.79102	PBF2	YDR120C|TRM1|S000002527|tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
YFR031C-A	5.7624	PBF2	YFR031C-A|RPL2A|S000002104|Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YFL015C	5.74725	PBF2	YFL015C||S000001879|Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YKL099C	5.72971	PBF2	YKL099C|UTP11|S000001582|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNL247W	5.68325	PBF2	YNL247W||S000005191|Essential protein of unknown function; may interact with ribosomes, based on co-purification experiments
YGR103W	5.68073	PBF2	YGR103W|NOP7|S000003335|Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of cell proliferation
YJL200C	5.63625	PBF2	YJL200C|ACO2|S000003736|Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YER126C	5.63103	PBF2	YER126C|NSA2|S000000928|Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YNL114C	5.62824	PBF2	YNL114C||S000005058|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YNR003C	5.55841	PBF2	YNR003C|RPC34|S000005286|RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YPL012W	5.54911	PBF2	YPL012W|RRP12|S000005933|Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats
YNL002C	5.54483	PBF2	YNL002C|RLP7|S000004947|Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
YNL065W	5.53358	PBF2	YNL065W|AQR1|S000005009|Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YLR129W	5.52123	PBF2	YLR129W|DIP2|S000004119|Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YDR398W	5.50732	PBF2	YDR398W|UTP5|S000002806|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YIR012W	5.50553	PBF2	YIR012W|SQT1|S000001451|Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
YDR033W	5.49362	PBF2	YDR033W|MRH1|S000002440|Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YHR070C-A	5.47685	PBF2	YHR070C-A||S000028780|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YCL036W	5.44702	PBF2	YCL036W|GFD2|S000000541|Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YKL014C	5.44683	PBF2	YKL014C|URB1|S000001497|Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YOR243C	5.44527	PBF2	YOR243C|PUS7|S000005769|Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates
YNL089C	5.42423	PBF2	YNL089C||S000005033|Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
YIL056W	5.40986	PBF2	YIL056W|VHR1|S000001318|Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YER001W	5.39837	PBF2	YER001W|MNN1|S000000803|Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YJL009W	5.34778	PBF2	YJL009W||S000003546|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
YBR244W	5.3475	PBF2	YBR244W|GPX2|S000000448|Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YHR052W	5.34652	PBF2	YHR052W|CIC1|S000001094|Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YDL153C	5.33299	PBF2	YDL153C|SAS10|S000002312|Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing
YLL011W	5.32366	PBF2	YLL011W|SOF1|S000003934|Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
YBL092W	5.3082	PBF2	YBL092W|RPL32|S000000188|Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YDR279W	5.29826	PBF2	YDR279W|RNH202|S000002687|Ribonuclease H2 subunit, required for RNase H2 activity
YPL086C	5.26835	PBF2	YPL086C|ELP3|S000006007|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
YPL239W	5.25296	PBF2	YPL239W|YAR1|S000006160|Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YLR363W-A	5.21391	PBF2	YLR363W-A||S000007620|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YDR101C	5.21217	PBF2	YDR101C|ARX1|S000002508|Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YOR206W	5.19502	PBF2	YOR206W|NOC2|S000005732|Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YPL043W	5.18716	PBF2	YPL043W|NOP4|S000005964|Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
YKL078W	5.17148	PBF2	YKL078W|DHR2|S000001561|Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
YDR450W	5.15271	PBF2	YDR450W|RPS18A|S000002858|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YBR126W-A	5.14796	PBF2	YBR126W-A||S000028600|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YHR197W	5.13618	PBF2	YHR197W|RIX1|S000001240|Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YER049W	5.13475	PBF2	YER049W|TPA1|S000000851|Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YOR376W-A	5.13032	PBF2	YOR376W-A||S000028586|Putative protein of unknown function; identified by fungal homology and RT-PCR
YOR025W	5.1236	PBF2	YOR025W|HST3|S000005551|Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YHR181W	5.11968	PBF2	YHR181W|SVP26|S000001224|Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YHR169W	5.10361	PBF2	YHR169W|DBP8|S000001212|Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit
YLR413W	5.08668	PBF2	YLR413W||S000004405|Putative protein of unknown function; YLR413W is not an essential gene
YDR021W	5.08108	PBF2	YDR021W|FAL1|S000002428|Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YNL110C	5.0648	PBF2	YNL110C|NOP15|S000005054|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YGR086C	5.05808	PBF2	YGR086C|PIL1|S000003318|Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YHR196W	5.02287	PBF2	YHR196W|UTP9|S000001239|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YJR145C	5.00645	PBF2	YJR145C|RPS4A|S000003906|Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YMR123W	5.00288	PBF2	YMR123W|PKR1|S000004730|V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YBL070C	4.99273	PBF2	YBL070C||S000000166|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR118W	4.95825	PBF2	YBR118W|TEF2|S000000322|Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YJL069C	4.95425	PBF2	YJL069C|UTP18|S000003605|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YJR094W-A	4.9527	PBF2	YJR094W-A|RPL43B|S000003855|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YEL001C	4.95199	PBF2	YEL001C|IRC22|S000000727|Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YGR200C	4.92642	PBF2	YGR200C|ELP2|S000003432|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YGL171W	4.91932	PBF2	YGL171W|ROK1|S000003139|ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis
YCR016W	4.91894	PBF2	YCR016W||S000000609|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YDR083W	4.91512	PBF2	YDR083W|RRP8|S000002490|Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation
YDR361C	4.89431	PBF2	YDR361C|BCP1|S000002769|Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
YLR154W-C	4.84357	PBF2	YLR154W-C|TAR1|S000028422|Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YPL266W	4.83879	PBF2	YPL266W|DIM1|S000006187|Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YHR144C	4.82318	PBF2	YHR144C|DCD1|S000001187|Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YHR149C	4.81191	PBF2	YHR149C|SKG6|S000001192|Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YDR261C	4.80959	PBF2	YDR261C|EXG2|S000002669|Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YIL078W	4.79347	PBF2	YIL078W|THS1|S000001340|Threonyl-tRNA synthetase, essential cytoplasmic protein
YJR097W	4.75361	PBF2	YJR097W|JJJ3|S000003858|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YDR384C	4.73449	PBF2	YDR384C|ATO3|S000002792|Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YGR040W	4.73054	PBF2	YGR040W|KSS1|S000003272|Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YOR226C	4.7205	PBF2	YOR226C|ISU2|S000005752|Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YNL075W	4.71038	PBF2	YNL075W|IMP4|S000005019|Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YIL127C	4.68722	PBF2	YIL127C||S000001389|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YMR113W	4.67478	PBF2	YMR113W|FOL3|S000004719|Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
YLL034C	4.6734	PBF2	YLL034C|RIX7|S000003957|Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
YCR057C	4.66368	PBF2	YCR057C|PWP2|S000000653|Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
YDL031W	4.65975	PBF2	YDL031W|DBP10|S000002189|Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
YKL218C	4.64996	PBF2	YKL218C|SRY1|S000001701|3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YMR112C	4.64789	PBF2	YMR112C|MED11|S000004718|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
YLR435W	4.6459	PBF2	YLR435W|TSR2|S000004427|Protein with a potential role in pre-rRNA processing
YGR124W	4.64138	PBF2	YGR124W|ASN2|S000003356|Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YHR170W	4.62706	PBF2	YHR170W|NMD3|S000001213|Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YER006W	4.59732	PBF2	YER006W|NUG1|S000000808|GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
YER156C	4.58405	PBF2	YER156C||S000000958|Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YEL068C	4.55801	PBF2	YEL068C||S000000794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR105W	4.55678	PBF2	YJR105W|ADO1|S000003866|Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YCL024W	4.55276	PBF2	YCL024W|KCC4|S000000529|Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YDL121C	4.5031	PBF2	YDL121C||S000002279|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YOR287C	4.48543	PBF2	YOR287C||S000005813|Putative protein of unknown function; may play a role in the ribosome and rRNA biosynthesis based on expression profiles and mutant phenotype
YOL085C	4.45123	PBF2	YOL085C||S000005445|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YOR375C	4.44593	PBF2	YOR375C|GDH1|S000005902|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YLR276C	4.43813	PBF2	YLR276C|DBP9|S000004266|ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit
YKL120W	4.40084	PBF2	YKL120W|OAC1|S000001603|Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YOR294W	4.38512	PBF2	YOR294W|RRS1|S000005820|Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice
YMR116C	4.35921	PBF2	YMR116C|ASC1|S000004722|G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YBR104W	4.35297	PBF2	YBR104W|YMC2|S000000308|Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YOR224C	4.32733	PBF2	YOR224C|RPB8|S000005750|RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YBL031W	4.32462	PBF2	YBL031W|SHE1|S000000127|Cytoskeletal protein of unknown function; overexpression causes growth arrest
YLR212C	4.27174	PBF2	YLR212C|TUB4|S000004202|Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YKL181W	4.25488	PBF2	YKL181W|PRS1|S000001664|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YDL047W	4.25406	PBF2	YDL047W|SIT4|S000002205|Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YJL011C	4.23032	PBF2	YJL011C|RPC17|S000003548|RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YCL063W	4.22527	PBF2	YCL063W|VAC17|S000000568|Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YJL198W	4.2239	PBF2	YJL198W|PHO90|S000003734|Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YOR341W	4.20693	PBF2	YOR341W|RPA190|S000005868|RNA polymerase I subunit; largest subunit of RNA polymerase I
YKL110C	4.19996	PBF2	YKL110C|KTI12|S000001593|Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YNL301C	4.19658	PBF2	YNL301C|RPL18B|S000005245|Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YDR509W	4.11671	PBF2	YDR509W||S000002917|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR162W-A	4.10434	PBF2	YLR162W-A||S000028567|Putative protein of unknown function identified by fungal homology comparisons and RT-PCR
YDL213C	4.10241	PBF2	YDL213C|NOP6|S000002372|Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YBL069W	4.09039	PBF2	YBL069W|AST1|S000000165|Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts
YLR221C	4.08845	PBF2	YLR221C|RSA3|S000004211|Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
YDL229W	4.06232	PBF2	YDL229W|SSB1|S000002388|Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
YBR034C	4.05989	PBF2	YBR034C|HMT1|S000000238|Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants
YDR454C	4.04692	PBF2	YDR454C|GUK1|S000002862|Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YDR508C	4.02926	PBF2	YDR508C|GNP1|S000002916|High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YOR078W	4.02013	PBF2	YOR078W|BUD21|S000005604|Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
YPR137W	3.99712	PBF2	YPR137W|RRP9|S000006341|Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YNL132W	3.98817	PBF2	YNL132W|KRE33|S000005076|Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YMR142C	3.96197	PBF2	YMR142C|RPL13B|S000004750|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YPR136C	3.95645	PBF2	YPR136C||S000006340|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
YOR342C	3.94814	PBF2	YOR342C||S000005869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YGL009C	3.9344	PBF2	YGL009C|LEU1|S000002977|Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YDR447C	3.93113	PBF2	YDR447C|RPS17B|S000002855|Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YMR143W	3.93094	PBF2	YMR143W|RPS16A|S000004751|Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YCR087C-A	3.90644	PBF2	YCR087C-A|LUG1|S000007223|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YPL062W	3.90352	PBF2	YPL062W||S000005983|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YDR365C	3.83964	PBF2	YDR365C|ESF1|S000002773|Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YCR072C	3.83421	PBF2	YCR072C|RSA4|S000000668|WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YDR161W	3.83095	PBF2	YDR161W||S000002568|Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation
YCL023C	3.81628	PBF2	YCL023C||S000000528|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YBL024W	3.79485	PBF2	YBL024W|NCL1|S000000120|S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YBR069C	3.76127	PBF2	YBR069C|TAT1|S000000273|Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YKR099W	3.76061	PBF2	YKR099W|BAS1|S000001807|Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YML056C	3.72241	PBF2	YML056C|IMD4|S000004520|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YLL064C	3.71002	PBF2	YLL064C|PAU18|S000003987|Hypothetical protein
YNL256W	3.69888	PBF2	YNL256W|FOL1|S000005200|Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YNL130C	3.69877	PBF2	YNL130C|CPT1|S000005074|Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
YER036C	3.6969	PBF2	YER036C|ARB1|S000000838|ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YLL035W	3.68804	PBF2	YLL035W|GRC3|S000003958|Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated
YPL141C	3.67922	PBF2	YPL141C||S000006062|Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YOR063W	3.6764	PBF2	YOR063W|RPL3|S000005589|Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YDR346C	3.66704	PBF2	YDR346C|SVF1|S000002754|Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YGR180C	3.66067	PBF2	YGR180C|RNR4|S000003412|Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YNL255C	3.62311	PBF2	YNL255C|GIS2|S000005199|Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway
YHR039C-A	3.61624	PBF2	YHR039C-A|VMA10|S000002100|Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification
YLR197W	3.61271	PBF2	YLR197W|SIK1|S000004187|Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YDR110W	3.59072	PBF2	YDR110W|FOB1|S000002517|Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases
YDL152W	3.58918	PBF2	YDL152W||S000002311|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
YGR271C-A	3.57748	PBF2	YGR271C-A|EFG1|S000007608|Protein of unknown function; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YPL112C	3.56907	PBF2	YPL112C|PEX25|S000006033|Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YLR172C	3.55745	PBF2	YLR172C|DPH5|S000004162|Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
YOL124C	3.5548	PBF2	YOL124C|TRM11|S000005484|Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YDL240W	3.55168	PBF2	YDL240W|LRG1|S000002399|Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YMR205C	3.5365	PBF2	YMR205C|PFK2|S000004818|Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YHR065C	3.52399	PBF2	YHR065C|RRP3|S000001107|Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
YBR011C	3.51842	PBF2	YBR011C|IPP1|S000000215|Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YMR199W	3.49919	PBF2	YMR199W|CLN1|S000004812|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGR285C	3.4842	PBF2	YGR285C|ZUO1|S000003517|Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YML093W	3.47777	PBF2	YML093W|UTP14|S000004558|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YPR051W	3.46545	PBF2	YPR051W|MAK3|S000006255|Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
YKR060W	3.46189	PBF2	YKR060W|UTP30|S000001768|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YEL056W	3.44095	PBF2	YEL056W|HAT2|S000000782|Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YCL064C	3.44031	PBF2	YCL064C|CHA1|S000000569|Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YBR247C	3.41231	PBF2	YBR247C|ENP1|S000000451|Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YDR184C	3.41198	PBF2	YDR184C|ATC1|S000002592|Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern
YHR180W-A	3.40951	PBF2	YHR180W-A||S000028555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YJL109C	3.40455	PBF2	YJL109C|UTP10|S000003645|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGL097W	3.39894	PBF2	YGL097W|SRM1|S000003065|Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YOR234C	3.39664	PBF2	YOR234C|RPL33B|S000005760|Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YBR126C	3.39656	PBF2	YBR126C|TPS1|S000000330|Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YER082C	3.38795	PBF2	YER082C|UTP7|S000000884|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YPL183C	3.37305	PBF2	YPL183C|RTT10|S000006104|Cytoplasmic protein with a role in regulation of Ty1 transposition
YLR397C	3.37255	PBF2	YLR397C|AFG2|S000004389|ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs
YBR257W	3.36514	PBF2	YBR257W|POP4|S000000461|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
YGR017W	3.36004	PBF2	YGR017W||S000003249|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YGR234W	3.3518	PBF2	YGR234W|YHB1|S000003466|Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YPR110C	3.33383	PBF2	YPR110C|RPC40|S000006314|RNA polymerase subunit, common to RNA polymerase I and III
YMR230W	3.33256	PBF2	YMR230W|RPS10B|S000004843|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
YJL169W	3.33177	PBF2	YJL169W||S000003705|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
YAL036C	3.32756	PBF2	YAL036C|RBG1|S000000034|Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p
YOR260W	3.32412	PBF2	YOR260W|GCD1|S000005786|Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YML022W	3.31675	PBF2	YML022W|APT1|S000004484|Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YCL037C	3.30341	PBF2	YCL037C|SRO9|S000000542|Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif
YLR351C	3.30034	PBF2	YLR351C|NIT3|S000004343|Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YDL062W	3.29534	PBF2	YDL062W||S000002220|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential
YDR165W	3.29379	PBF2	YDR165W|TRM82|S000002572|Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YEL066W	3.29225	PBF2	YEL066W|HPA3|S000000792|D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YJR041C	3.27585	PBF2	YJR041C|URB2|S000003802|Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
YGL209W	3.26142	PBF2	YGL209W|MIG2|S000003177|Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YDR496C	3.25486	PBF2	YDR496C|PUF6|S000002904|Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA
YGL169W	3.23863	PBF2	YGL169W|SUA5|S000003137|Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start
YOR359W	3.2179	PBF2	YOR359W|VTS1|S000005886|Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic
YCR022C	3.19497	PBF2	YCR022C||S000000616|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YER168C	3.19394	PBF2	YER168C|CCA1|S000000970|ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
YOL103W	3.18472	PBF2	YOL103W|ITR2|S000005463|Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YBR023C	3.17305	PBF2	YBR023C|CHS3|S000000227|Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YER149C	3.16659	PBF2	YER149C|PEA2|S000000951|Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
YLR222C	3.1611	PBF2	YLR222C|UTP13|S000004212|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YOL125W	3.1611	PBF2	YOL125W|TRM13|S000005485|2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases
YGR158C	3.15826	PBF2	YGR158C|MTR3|S000003390|3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH
YMR011W	3.14171	PBF2	YMR011W|HXT2|S000004613|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YNL061W	3.12169	PBF2	YNL061W|NOP2|S000005005|Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
YBR267W	3.12031	PBF2	YBR267W|REI1|S000000471|Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
YML018C	3.11665	PBF2	YML018C||S000004480|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene
YDL063C	3.10604	PBF2	YDL063C||S000002221|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL063C is not an essential gene
YGR138C	3.08908	PBF2	YGR138C|TPO2|S000003370|Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YBR066C	3.06375	PBF2	YBR066C|NRG2|S000000270|Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YGL099W	3.06099	PBF2	YGL099W|LSG1|S000003067|Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YKL143W	3.05559	PBF2	YKL143W|LTV1|S000001626|Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
YIL110W	3.0513	PBF2	YIL110W|MNI1|S000001372|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants
YOR021C	3.05124	PBF2	YOR021C||S000005547|Putative protein of unknown function; YOR021C is not an essential gene
YGR060W	3.03762	PBF2	YGR060W|ERG25|S000003292|C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YDR037W	3.00229	PBF2	YDR037W|KRS1|S000002444|Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YPR014C	2.97932	PBF2	YPR014C||S000006218|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YJL162C	2.96767	PBF2	YJL162C|JJJ2|S000003698|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YFR039C	2.96288	PBF2	YFR039C||S000001935|Putative protein of unknown function; may be involved in response to high salt and changes in carbon source
YOR273C	2.95151	PBF2	YOR273C|TPO4|S000005799|Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YGR181W	2.94491	PBF2	YGR181W|TIM13|S000003413|Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YFL016C	2.93561	PBF2	YFL016C|MDJ1|S000001878|Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YMR239C	2.93348	PBF2	YMR239C|RNT1|S000004852|RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end
YKL144C	2.93047	PBF2	YKL144C|RPC25|S000001627|RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
YBL003C	2.9246	PBF2	YBL003C|HTA2|S000000099|One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YER183C	2.90238	PBF2	YER183C|FAU1|S000000985|5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YER034W	2.87975	PBF2	YER034W||S000000836|Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
YEL067C	2.87625	PBF2	YEL067C||S000000793|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR140W	2.84374	PBF2	YGR140W|CBF2|S000003372|Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YNL251C	2.83209	PBF2	YNL251C|NRD1|S000005195|RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
YOR369C	2.82991	PBF2	YOR369C|RPS12|S000005896|Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YHR072W-A	2.77732	PBF2	YHR072W-A|NOP10|S000007455|Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA
YDR098C	2.77548	PBF2	YDR098C|GRX3|S000002505|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YNL119W	2.77344	PBF2	YNL119W|NCS2|S000005063|Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YKL128C	2.75416	PBF2	YKL128C|PMU1|S000001611|Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YLR063W	2.74797	PBF2	YLR063W||S000004053|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
YOR091W	2.74474	PBF2	YOR091W|TMA46|S000005617|Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p
YDR531W	2.71657	PBF2	YDR531W||S000002939|Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YPR043W	2.70951	PBF2	YPR043W|RPL43A|S000006247|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YIL069C	2.70645	PBF2	YIL069C|RPS24B|S000001331|Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YPL081W	2.7042	PBF2	YPL081W|RPS9A|S000006002|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YJL208C	2.69421	PBF2	YJL208C|NUC1|S000003744|Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
YHR069C	2.69126	PBF2	YHR069C|RRP4|S000001111|3'-5' exoribonuclease involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3p
YJL033W	2.67353	PBF2	YJL033W|HCA4|S000003570|Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
YNL280C	2.66861	PBF2	YNL280C|ERG24|S000005224|C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YOR119C	2.63594	PBF2	YOR119C|RIO1|S000005645|Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
YNL022C	2.6263	PBF2	YNL022C||S000004967|Putative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene
YOL109W	2.61691	PBF2	YOL109W|ZEO1|S000005469|Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
YDR091C	2.61584	PBF2	YDR091C|RLI1|S000002498|Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YGR081C	2.6077	PBF2	YGR081C|SLX9|S000003313|Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
YNR008W	2.58595	PBF2	YNR008W|LRO1|S000005291|Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
YBR106W	2.58213	PBF2	YBR106W|PHO88|S000000310|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YNL300W	2.57638	PBF2	YNL300W||S000005244|Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YOL022C	2.57497	PBF2	YOL022C|TSR4|S000005382|Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA
YBR256C	2.56206	PBF2	YBR256C|RIB5|S000000460|Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YDR280W	2.55196	PBF2	YDR280W|RRP45|S000002688|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YOR225W	2.55094	PBF2	YOR225W||S000005751|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YHR070W	2.54807	PBF2	YHR070W|TRM5|S000001112|tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
YOR026W	2.53252	PBF2	YOR026W|BUB3|S000005552|Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
YLR179C	2.51387	PBF2	YLR179C||S000004169|Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YHR172W	2.4792	PBF2	YHR172W|SPC97|S000001215|Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YEL055C	2.46196	PBF2	YEL055C|POL5|S000000781|DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
YER133W	2.45945	PBF2	YER133W|GLC7|S000000935|Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
YPR170W-B	2.45865	PBF2	YPR170W-B||S000028515|Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YNL207W	2.44615	PBF2	YNL207W|RIO2|S000005151|Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YJL125C	2.44521	PBF2	YJL125C|GCD14|S000003661|Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YGR283C	2.43745	PBF2	YGR283C||S000003515|Protein of unknown function; may interact with ribosomes, based on co-purification experiments; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YLR287C	2.42153	PBF2	YLR287C||S000004277|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
YHR088W	2.42023	PBF2	YHR088W|RPF1|S000001130|Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
YER110C	2.41575	PBF2	YER110C|KAP123|S000000912|Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
YDL167C	2.40579	PBF2	YDL167C|NRP1|S000002326|Protein of unknown function, rich in asparagine residues
YIL004C	2.38626	PBF2	YIL004C|BET1|S000001266|Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YPR074C	2.384	PBF2	YPR074C|TKL1|S000006278|Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YGR162W	2.37967	PBF2	YGR162W|TIF4631|S000003394|Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
YLL021W	2.3696	PBF2	YLL021W|SPA2|S000003944|Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YDR534C	2.36575	PBF2	YDR534C|FIT1|S000002942|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YLR074C	2.36118	PBF2	YLR074C|BUD20|S000004064|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YFR021W	2.35651	PBF2	YFR021W|ATG18|S000001917|Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
YIL019W	2.34704	PBF2	YIL019W|FAF1|S000001281|Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
YPR112C	2.34021	PBF2	YPR112C|MRD1|S000006316|Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains
YDR449C	2.33861	PBF2	YDR449C|UTP6|S000002857|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YML126C	2.32783	PBF2	YML126C|ERG13|S000004595|3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YHL011C	2.32724	PBF2	YHL011C|PRS3|S000001003|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YBL002W	2.3053	PBF2	YBL002W|HTB2|S000000098|One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YNL120C	2.29829	PBF2	YNL120C||S000005064|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
YPR048W	2.29138	PBF2	YPR048W|TAH18|S000006252|Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta
YMR259C	2.2833	PBF2	YMR259C||S000004872|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene
YNL151C	2.2793	PBF2	YNL151C|RPC31|S000005095|RNA polymerase III subunit C31; contains HMG-like C-terminal domain
YNL253W	2.2789	PBF2	YNL253W|TEX1|S000005197|Protein involved in mRNA export, component of the transcription export (TREX) complex
YMR093W	2.27766	PBF2	YMR093W|UTP15|S000004699|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YDR309C	2.27091	PBF2	YDR309C|GIC2|S000002717|Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YHR140W	2.26083	PBF2	YHR140W||S000001182|Putative integral membrane protein of unknown function
YML080W	2.2588	PBF2	YML080W|DUS1|S000004545|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
YFR051C	2.25586	PBF2	YFR051C|RET2|S000001947|Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YML060W	2.24912	PBF2	YML060W|OGG1|S000004525|Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA
YGR148C	2.2484	PBF2	YGR148C|RPL24B|S000003380|Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YOR355W	2.24781	PBF2	YOR355W|GDS1|S000005882|Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR094C	2.24776	PBF2	YKR094C|RPL40B|S000001802|Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YPL030W	2.24057	PBF2	YPL030W|TRM44|S000005951|tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
YDR278C	2.23668	PBF2	YDR278C||S000002686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR144C	2.21781	PBF2	YPR144C|NOC4|S000006348|Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YMR128W	2.20345	PBF2	YMR128W|ECM16|S000004735|Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
YIR020W-A	2.20265	PBF2	YIR020W-A||S000007241|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR274W	2.19384	PBF2	YOR274W|MOD5|S000005800|Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YLR243W	2.17871	PBF2	YLR243W||S000004233|Putative protein of unknown function; YLR243W is an essential gene
YPL146C	2.17455	PBF2	YPL146C|NOP53|S000006067|Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YCR035C	2.1673	PBF2	YCR035C|RRP43|S000000631|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA
YGR173W	2.16086	PBF2	YGR173W|RBG2|S000003405|Protein with similarity to mammalian developmentally regulated GTP-binding protein
YNL001W	2.15945	PBF2	YNL001W|DOM34|S000004946|Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota
YKL125W	2.15445	PBF2	YKL125W|RRN3|S000001608|Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA
YDR156W	2.14351	PBF2	YDR156W|RPA14|S000002563|RNA polymerase I subunit A14
YLR249W	2.14282	PBF2	YLR249W|YEF3|S000004239|Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YBR130C	2.14053	PBF2	YBR130C|SHE3|S000000334|Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YOL123W	2.1349	PBF2	YOL123W|HRP1|S000005483|Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YCL049C	2.12498	PBF2	YCL049C||S000000554|Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YIR019C	2.12195	PBF2	YIR019C|MUC1|S000001458|GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
YHR081W	2.12176	PBF2	YHR081W|LRP1|S000001123|Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YPR052C	2.11069	PBF2	YPR052C|NHP6A|S000006256|High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YDL048C	2.1091	PBF2	YDL048C|STP4|S000002206|Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YLR017W	2.1057	PBF2	YLR017W|MEU1|S000004007|Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
YLR254C	2.10253	PBF2	YLR254C|NDL1|S000004244|Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
YNL313C	2.10073	PBF2	YNL313C||S000005257|Putative protein of unknown function; identified as interacting with Kar2p, Grs1p, and Tub3p in high-throughput TAP-tagging experiments; YNL313C is an essential gene
YKL209C	2.07447	PBF2	YKL209C|STE6|S000001692|Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YAR071W	2.06545	PBF2	YAR071W|PHO11|S000000094|One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YIL133C	2.06528	PBF2	YIL133C|RPL16A|S000001395|N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YBL040C	2.06314	PBF2	YBL040C|ERD2|S000000136|HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
YBR243C	2.06309	PBF2	YBR243C|ALG7|S000000447|UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YPL207W	2.05943	PBF2	YPL207W|TYW1|S000006128|Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YER083C	2.05162	PBF2	YER083C|GET2|S000000885|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
YLR314C	2.04874	PBF2	YLR314C|CDC3|S000004306|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YER088C-A	2.018	PBF2	YER088C-A||S000028754|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR257W	2.01152	PBF2	YLR257W||S000004247|Putative protein of unknown function
YNL163C	1.99471	PBF2	YNL163C|RIA1|S000005107|Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)
YIR013C	1.99026	PBF2	YIR013C|GAT4|S000001452|Protein containing GATA family zinc finger motifs
YLL027W	1.98781	PBF2	YLL027W|ISA1|S000003950|Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YJL179W	1.97425	PBF2	YJL179W|PFD1|S000003715|Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
YML031C-A	1.94989	PBF2	YML031C-A||S000028809|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS
YNL062C	1.94837	PBF2	YNL062C|GCD10|S000005006|Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YPL217C	1.92965	PBF2	YPL217C|BMS1|S000006138|Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p
YLR341W	1.92325	PBF2	YLR341W|SPO77|S000004333|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YER131W	1.92017	PBF2	YER131W|RPS26B|S000000933|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YBR029C	1.91608	PBF2	YBR029C|CDS1|S000000233|Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
YGL245W	1.91528	PBF2	YGL245W|GUS1|S000003214|Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
YKL179C	1.90481	PBF2	YKL179C|COY1|S000001662|Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
YLL036C	1.90113	PBF2	YLL036C|PRP19|S000003959|Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases
YHR069C-A	1.89979	PBF2	YHR069C-A||S000028779|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR262C	1.89977	PBF2	YGR262C|BUD32|S000003494|Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p
YIL096C	1.89776	PBF2	YIL096C||S000001358|Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YER147C-A	1.89767	PBF2	YER147C-A||S000028759|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL056C	1.89121	PBF2	YKL056C|TMA19|S000001539|Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
YCR031C	1.88933	PBF2	YCR031C|RPS14A|S000000627|Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YHL003C	1.88605	PBF2	YHL003C|LAG1|S000000995|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YDL052C	1.87504	PBF2	YDL052C|SLC1|S000002210|1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
YBL018C	1.87122	PBF2	YBL018C|POP8|S000000114|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YLR336C	1.86657	PBF2	YLR336C|SGD1|S000004328|Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia
YPL068C	1.86271	PBF2	YPL068C||S000005989|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS
YGR139W	1.86087	PBF2	YGR139W||S000003371|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL127W	1.85008	PBF2	YKL127W|PGM1|S000001610|Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YLR002C	1.8389	PBF2	YLR002C|NOC3|S000003992|Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YNR024W	1.83703	PBF2	YNR024W||S000005307|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YIL020C	1.83234	PBF2	YIL020C|HIS6|S000001282|Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YML005W	1.83185	PBF2	YML005W|TRM12|S000004464|S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YPR190C	1.82511	PBF2	YPR190C|RPC82|S000006394|RNA polymerase III subunit C82
YNL084C	1.8191	PBF2	YNL084C|END3|S000005028|EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
YJL105W	1.81617	PBF2	YJL105W|SET4|S000003641|Protein of unknown function, contains a SET domain
YMR269W	1.81151	PBF2	YMR269W|TMA23|S000004882|Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YKR079C	1.79928	PBF2	YKR079C|TRZ1|S000001787|tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YPR170W-A	1.79717	PBF2	YPR170W-A||S000028861|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YLR268W	1.78983	PBF2	YLR268W|SEC22|S000004258|R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YLL022C	1.78715	PBF2	YLL022C|HIF1|S000003945|Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing
YJL025W	1.78691	PBF2	YJL025W|RRN7|S000003562|Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein
YDL212W	1.78029	PBF2	YDL212W|SHR3|S000002371|Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YOR095C	1.77703	PBF2	YOR095C|RKI1|S000005621|Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YHR085W	1.77244	PBF2	YHR085W|IPI1|S000001127|Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YGL158W	1.76161	PBF2	YGL158W|RCK1|S000003126|Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YOR207C	1.75546	PBF2	YOR207C|RET1|S000005733|Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
YDL205C	1.75121	PBF2	YDL205C|HEM3|S000002364|Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YKL211C	1.74979	PBF2	YKL211C|TRP3|S000001694|Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YBR158W	1.74311	PBF2	YBR158W|AMN1|S000000362|Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YJL026W	1.73198	PBF2	YJL026W|RNR2|S000003563|Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YGL039W	1.72685	PBF2	YGL039W||S000003007|Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YOR319W	1.72406	PBF2	YOR319W|HSH49|S000005846|U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YIL015W	1.71013	PBF2	YIL015W|BAR1|S000001277|Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YLR146C	1.70791	PBF2	YLR146C|SPE4|S000004136|Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
YHL039W	1.70668	PBF2	YHL039W||S000001031|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YBR227C	1.69979	PBF2	YBR227C|MCX1|S000000431|Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins
YPL037C	1.69899	PBF2	YPL037C|EGD1|S000005958|Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YNL123W	1.69635	PBF2	YNL123W|NMA111|S000005067|Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YOL144W	1.69237	PBF2	YOL144W|NOP8|S000005504|Nucleolar protein required for 60S ribosomal subunit biogenesis
YDL241W	1.68702	PBF2	YDL241W||S000002400|Putative protein of unknown function; YDL241W is not an essential gene
YNL162W-A	1.68523	PBF2	YNL162W-A||S000007624|Putative protein of unknown function, identified by homology
YPR080W	1.68387	PBF2	YPR080W|TEF1|S000006284|Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YOL136C	1.68107	PBF2	YOL136C|PFK27|S000005496|6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YOL054W	1.67509	PBF2	YOL054W|PSH1|S000005415|Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein
YDR211W	1.66299	PBF2	YDR211W|GCD6|S000002619|Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YGR095C	1.65739	PBF2	YGR095C|RRP46|S000003327|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YLR183C	1.65098	PBF2	YLR183C|TOS4|S000004173|Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YLR185W	1.64895	PBF2	YLR185W|RPL37A|S000004175|Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YER127W	1.63318	PBF2	YER127W|LCP5|S000000929|Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
YLR224W	1.63228	PBF2	YLR224W||S000004214|F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
YCR054C	1.62732	PBF2	YCR054C|CTR86|S000000650|Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis
YJR042W	1.62049	PBF2	YJR042W|NUP85|S000003803|Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking
YBL068W-A	1.61303	PBF2	YBL068W-A||S000028530|Dubious open reading frame unlikely to encode a protein; identified by fungal homology and RT-PCR
YFL026W	1.61117	PBF2	YFL026W|STE2|S000001868|Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YLR049C	1.60439	PBF2	YLR049C||S000004039|Putative protein of unknown function
YGR130C	1.59313	PBF2	YGR130C||S000003362|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YGL258W	1.57707	PBF2	YGL258W|VEL1|S000003227|Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YHR039C	1.56971	PBF2	YHR039C|MSC7|S000001081|Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
YLR367W	1.56749	PBF2	YLR367W|RPS22B|S000004359|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YLR067C	1.56232	PBF2	YLR067C|PET309|S000004057|Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane
YPR171W	1.56226	PBF2	YPR171W|BSP1|S000006375|Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YML125C	1.56147	PBF2	YML125C|PGA3|S000004594|Essential protein required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect
YLR051C	1.55822	PBF2	YLR051C|FCF2|S000004041|Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon
YGL034C	1.55137	PBF2	YGL034C||S000003002|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR006C	1.54995	PBF2	YCR006C||S000000599|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL222W	1.54066	PBF2	YJL222W|VTH2|S000003758|Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
YIR020C	1.5357	PBF2	YIR020C||S000001459|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL160W	1.51801	PBF2	YPL160W|CDC60|S000006081|Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YML082W	1.51646	PBF2	YML082W||S000004547|Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YJR076C	1.50334	PBF2	YJR076C|CDC11|S000003837|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YGL028C	1.49258	PBF2	YGL028C|SCW11|S000002996|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YEL048C	1.48822	PBF2	YEL048C||S000000774|Putative protein of unknown function; synthetic lethal with gcs1delta
YJL026C-A	1.48641	PBF2	YJL026C-A||S000028660|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2
YML031W	1.48315	PBF2	YML031W|NDC1|S000004493|Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II
YGR090W	1.46235	PBF2	YGR090W|UTP22|S000003322|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YIL131C	1.45597	PBF2	YIL131C|FKH1|S000001393|Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
YBR084C-A	1.45219	PBF2	YBR084C-A|RPL19A|S000002156|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YER091C	1.44856	PBF2	YER091C|MET6|S000000893|Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YGL246C	1.44851	PBF2	YGL246C|RAI1|S000003215|Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing
YBR030W	1.44591	PBF2	YBR030W||S000000234|Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold)
YPR053C	1.4458	PBF2	YPR053C||S000006257|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
YCR019W	1.44125	PBF2	YCR019W|MAK32|S000000612|Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YLR401C	1.44079	PBF2	YLR401C|DUS3|S000004393|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YMR105W-A	1.43414	PBF2	YMR105W-A||S000028692|Putative protein of unknown function
YBR012C	1.42439	PBF2	YBR012C||S000000216|Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YPR149W	1.42198	PBF2	YPR149W|NCE102|S000006353|Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YDR302W	1.41378	PBF2	YDR302W|GPI11|S000002710|ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YOR252W	1.40262	PBF2	YOR252W|TMA16|S000005778|Protein of unknown function that associates with ribosomes
YGR121W-A	1.40059	PBF2	YGR121W-A||S000028550|Putative protein of unknown function
YDR017C	1.39914	PBF2	YDR017C|KCS1|S000002424|Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
YKL191W	1.39616	PBF2	YKL191W|DPH2|S000001674|Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
YJL124C	1.38762	PBF2	YJL124C|LSM1|S000003660|Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
YDR341C	1.36959	PBF2	YDR341C||S000002749|Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR243C	1.36716	PBF2	YDR243C|PRP28|S000002651|RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
YDR240C	1.36296	PBF2	YDR240C|SNU56|S000002648|Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YJR002W	1.35701	PBF2	YJR002W|MPP10|S000003762|Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
YER159C	1.35468	PBF2	YER159C|BUR6|S000000961|Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YPR170C	1.34251	PBF2	YPR170C||S000006374|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YHR143W-A	1.34006	PBF2	YHR143W-A|RPC10|S000001185|RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
YDR371W	1.33731	PBF2	YDR371W|CTS2|S000002779|Sporulation-specific chitinase
YER090W	1.32047	PBF2	YER090W|TRP2|S000000892|Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YOL010W	1.31904	PBF2	YOL010W|RCL1|S000005370|RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity
YER148W	1.3181	PBF2	YER148W|SPT15|S000000950|TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YFL014W	1.31573	PBF2	YFL014W|HSP12|S000001880|Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YML119W	1.31259	PBF2	YML119W||S000004588|Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YMR208W	1.31253	PBF2	YMR208W|ERG12|S000004821|Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YJL223C	1.30866	PBF2	YJL223C|PAU1|S000003759|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR345C	1.3059	PBF2	YDR345C|HXT3|S000002753|Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YJR007W	1.30215	PBF2	YJR007W|SUI2|S000003767|Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP
YDR370C	1.30109	PBF2	YDR370C||S000002778|Putative protein of unknown function
YOR001W	1.29587	PBF2	YOR001W|RRP6|S000005527|Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
YCR045C	1.29127	PBF2	YCR045C||S000000641|Putative protein of unknown function
YGL035C	1.28696	PBF2	YGL035C|MIG1|S000003003|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YGR131W	1.28636	PBF2	YGR131W||S000003363|Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YLR442C	1.28623	PBF2	YLR442C|SIR3|S000004434|Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p
YIL003W	1.28483	PBF2	YIL003W|CFD1|S000001265|Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
YER180C-A	1.28267	PBF2	YER180C-A|SLO1|S000028437|Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
YER136W	1.27585	PBF2	YER136W|GDI1|S000000938|GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YNL229C	1.27506	PBF2	YNL229C|URE2|S000005173|Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
YOL031C	1.26706	PBF2	YOL031C|SIL1|S000005391|Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YDR535C	1.25721	PBF2	YDR535C||S000002943|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YNL299W	1.25398	PBF2	YNL299W|TRF5|S000005243|Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase
YHR010W	1.24889	PBF2	YHR010W|RPL27A|S000001052|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YDL030W	1.24691	PBF2	YDL030W|PRP9|S000002188|Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
YDR276C	1.24368	PBF2	YDR276C|PMP3|S000002684|Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YER134C	1.24292	PBF2	YER134C||S000000936|Putative protein of unknown function; non-essential gene
YIL079C	1.24188	PBF2	YIL079C|AIR1|S000001341|RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p
YHR041C	1.23812	PBF2	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YIL119C	1.23151	PBF2	YIL119C|RPI1|S000001381|Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YNR015W	1.22919	PBF2	YNR015W|SMM1|S000005298|Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
YGR106C	1.22375	PBF2	YGR106C|VOA1|S000003338|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YDR491C	1.2203	PBF2	YDR491C||S000002899|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR318C	1.2176	PBF2	YOR318C||S000005845|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
YOR354C	1.21469	PBF2	YOR354C|MSC6|S000005881|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR242W	1.21433	PBF2	YBR242W||S000000446|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YCR047C	1.21161	PBF2	YCR047C|BUD23|S000000643|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YJL222W-A	1.21077	PBF2	YJL222W-A||S000028663|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR099W	1.20484	PBF2	YOR099W|KTR1|S000005625|Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YIL104C	1.20161	PBF2	YIL104C|SHQ1|S000001366|Essential nuclear protein, required for accumulation of box H/ACA snoRNAs and for rRNA processing; interacts with Naf1p
YCR101C	1.19891	PBF2	YCR101C||S000000698|Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
YLR384C	1.1972	PBF2	YLR384C|IKI3|S000004376|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
YGR195W	1.19466	PBF2	YGR195W|SKI6|S000003427|3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YLR312W-A	1.17824	PBF2	YLR312W-A|MRPL15|S000004304|Mitochondrial ribosomal protein of the large subunit
YMR244C-A	1.1761	PBF2	YMR244C-A||S000004857|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
YPR058W	1.16013	PBF2	YPR058W|YMC1|S000006262|Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p
YNL182C	1.15949	PBF2	YNL182C|IPI3|S000005126|Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YMR009W	1.15813	PBF2	YMR009W|ADI1|S000004611|Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YPL242C	1.15394	PBF2	YPL242C|IQG1|S000006163|Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family
YPR104C	1.15332	PBF2	YPR104C|FHL1|S000006308|Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4
YPL118W	1.15042	PBF2	YPL118W|MRP51|S000006039|Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YDR076W	1.14437	PBF2	YDR076W|RAD55|S000002483|Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
YDR510W	1.14412	PBF2	YDR510W|SMT3|S000002918|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YBL004W	1.14342	PBF2	YBL004W|UTP20|S000000100|Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
YIL053W	1.14337	PBF2	YIL053W|RHR2|S000001315|Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YEL020C-B	1.1409	PBF2	YEL020C-B||S000028544|Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YDR434W	1.13653	PBF2	YDR434W|GPI17|S000002842|Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
YKR036C	1.12884	PBF2	YKR036C|CAF4|S000001744|WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission
YOR212W	1.12854	PBF2	YOR212W|STE4|S000005738|G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YPR195C	1.12732	PBF2	YPR195C||S000006399|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL172W	1.12645	PBF2	YGL172W|NUP49|S000003140|Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes
YGL234W	1.12145	PBF2	YGL234W|ADE5,7|S000003203|Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
YGL040C	1.09519	PBF2	YGL040C|HEM2|S000003008|Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YPL053C	1.07751	PBF2	YPL053C|KTR6|S000005974|Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family
YHR060W	1.07687	PBF2	YHR060W|VMA22|S000001102|Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YDR497C	1.07575	PBF2	YDR497C|ITR1|S000002905|Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YPR074W-A	1.07107	PBF2	YPR074W-A||S000007631|Hypothetical protein identified by homology
YHR136C	1.06524	PBF2	YHR136C|SPL2|S000001178|Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER064C	1.04393	PBF2	YER064C||S000000866|Non-essential nuclear protein; null mutation has global effects on transcription
YML122C	1.03791	PBF2	YML122C||S000004591|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL101C	1.03237	PBF2	YOL101C|IZH4|S000005461|Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YER037W	1.03213	PBF2	YER037W|PHM8|S000000839|Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p
YOR029W	1.03126	PBF2	YOR029W||S000005555|Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKR013W	1.02378	PBF2	YKR013W|PRY2|S000001721|Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YPR146C	1.02149	PBF2	YPR146C||S000006350|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL026W	1.02008	PBF2	YEL026W|SNU13|S000000752|RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YBR085W	1.00737	PBF2	YBR085W|AAC3|S000000289|Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YDR121W	1.00721	PBF2	YDR121W|DPB4|S000002528|Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
YBL044W	1.00651	PBF2	YBL044W||S000000140|Putative protein of unknown function; YBL044W is not an essential protein
YCR008W	1.00195	PBF2	YCR008W|SAT4|S000000601|Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YIL008W	0.995403	PBF2	YIL008W|URM1|S000001270|Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YGR107W	0.986489	PBF2	YGR107W||S000003339|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL257C	0.985149	PBF2	YNL257C|SIP3|S000005201|Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate
YOR323C	0.97905	PBF2	YOR323C|PRO2|S000005850|Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YPR062W	0.978583	PBF2	YPR062W|FCY1|S000006266|Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YPL010W	0.977895	PBF2	YPL010W|RET3|S000005931|Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YNL209W	0.974969	PBF2	YNL209W|SSB2|S000005153|Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1
YKL015W	0.973117	PBF2	YKL015W|PUT3|S000001498|Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain
YLR285C-A	0.971767	PBF2	YLR285C-A||S000028569|Putative protein of unknown function; identified by fungal homology and RT-PCR
YLR026C	0.967788	PBF2	YLR026C|SED5|S000004016|cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
YLR238W	0.966239	PBF2	YLR238W|FAR10|S000004228|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
YDR020C	0.964024	PBF2	YDR020C|DAS2|S000002427|Predicted protein shares weak similarity with uridine kinases and with phosphoribokinases; null mutant suppresses dst1delta sensitivity for 6-azauracil
YOR146W	0.960121	PBF2	YOR146W||S000005672|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YJR064W	0.957295	PBF2	YJR064W|CCT5|S000003825|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YLR215C	0.94857	PBF2	YLR215C|CDC123|S000004205|Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
YKL082C	0.939723	PBF2	YKL082C|RRP14|S000001565|Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
YNL292W	0.938519	PBF2	YNL292W|PUS4|S000005236|Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)
YGR253C	0.938007	PBF2	YGR253C|PUP2|S000003485|Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YDR072C	0.937792	PBF2	YDR072C|IPT1|S000002479|Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YMR228W	0.934634	PBF2	YMR228W|MTF1|S000004841|Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p
YML014W	0.932069	PBF2	YML014W|TRM9|S000004476|tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); deletion confers resistance to zymocin
YBR164C	0.932044	PBF2	YBR164C|ARL1|S000000368|Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YJL012C	0.928523	PBF2	YJL012C|VTC4|S000003549|Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YLR195C	0.926628	PBF2	YLR195C|NMT1|S000004185|N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
YNL043C	0.925481	PBF2	YNL043C||S000004988|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YAL053W	0.925021	PBF2	YAL053W|FLC2|S000000049|Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YOL102C	0.924803	PBF2	YOL102C|TPT1|S000005462|tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
YMR229C	0.92127	PBF2	YMR229C|RRP5|S000004842|RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome
YHL013C	0.919038	PBF2	YHL013C|OTU2|S000001005|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
YNL066W	0.915986	PBF2	YNL066W|SUN4|S000005010|Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YBR275C	0.915364	PBF2	YBR275C|RIF1|S000000479|Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YOR335C	0.913885	PBF2	YOR335C|ALA1|S000005862|Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
YMR141W-A	0.909871	PBF2	YMR141W-A||S000028575|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C
YGL253W	0.90456	PBF2	YGL253W|HXK2|S000003222|Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YNR038W	0.902505	PBF2	YNR038W|DBP6|S000005321|Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YML111W	0.897043	PBF2	YML111W|BUL2|S000004579|Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YOR028C	0.893006	PBF2	YOR028C|CIN5|S000005554|Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YLR256W	0.890854	PBF2	YLR256W|HAP1|S000004246|Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YLR186W	0.883481	PBF2	YLR186W|EMG1|S000004176|Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers
YNR012W	0.883063	PBF2	YNR012W|URK1|S000005295|Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
YCR047W-A	0.883038	PBF2	YCR047W-A||S000028608|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YCL058W-A	0.873604	PBF2	YCL058W-A||S000028518|Protein of unknown function; identified by homology to Ashbya gossypii
YDR012W	0.873085	PBF2	YDR012W|RPL4B|S000002419|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
YGR187C	0.871941	PBF2	YGR187C|HGH1|S000003419|Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YJR124C	0.869719	PBF2	YJR124C||S000003885|Putative protein of unknown function; expression induced under calcium shortage
YDR448W	0.868462	PBF2	YDR448W|ADA2|S000002856|Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
YER169W	0.866987	PBF2	YER169W|RPH1|S000000971|JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
YJR114W	0.864192	PBF2	YJR114W||S000003875|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YDR326C	0.861629	PBF2	YDR326C|YSP2|S000002734|Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification
YML006C	0.857376	PBF2	YML006C|GIS4|S000004465|CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YOL013W-A	0.853844	PBF2	YOL013W-A||S000028811|Putative protein of unknown function; identified by SAGE
YNR013C	0.840046	PBF2	YNR013C|PHO91|S000005296|Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YPR069C	0.838684	PBF2	YPR069C|SPE3|S000006273|Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YGL106W	0.83739	PBF2	YGL106W|MLC1|S000003074|Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition
YNR075W	0.833148	PBF2	YNR075W|COS10|S000005358|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YML075C	0.83168	PBF2	YML075C|HMG1|S000004540|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YBR061C	0.831535	PBF2	YBR061C|TRM7|S000000265|2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
YPL157W	0.81816	PBF2	YPL157W|TGS1|S000006078|Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology
YOR218C	0.817518	PBF2	YOR218C||S000005744|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
YGL111W	0.817031	PBF2	YGL111W|NSA1|S000003079|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YGL067W	0.813194	PBF2	YGL067W|NPY1|S000003035|NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
YKR012C	0.812134	PBF2	YKR012C||S000001720|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YGL016W	0.811069	PBF2	YGL016W|KAP122|S000002984|Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
YIL016W	0.803357	PBF2	YIL016W|SNL1|S000001278|Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein
YIL021W	0.802324	PBF2	YIL021W|RPB3|S000001283|RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YGL201C	0.801346	PBF2	YGL201C|MCM6|S000003169|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YML028W	0.80065	PBF2	YML028W|TSA1|S000004490|Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype
YBR125C	0.796805	PBF2	YBR125C|PTC4|S000000329|Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
YPL137C	0.795026	PBF2	YPL137C|GIP3|S000006058|Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YKL097C	0.787431	PBF2	YKL097C||S000001580|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YBR187W	0.785893	PBF2	YBR187W|GDT1|S000000391|Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis
YNR074C	0.784732	PBF2	YNR074C|AIF1|S000005357|Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
YER016W	0.784594	PBF2	YER016W|BIM1|S000000818|Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YOR048C	0.781111	PBF2	YOR048C|RAT1|S000005574|Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination
YGR146C-A	0.778719	PBF2	YGR146C-A||S000028638|Putative protein of unknown function
YGL179C	0.77767	PBF2	YGL179C|TOS3|S000003147|Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGR259C	0.774937	PBF2	YGR259C||S000003491|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YNL166C	0.774054	PBF2	YNL166C|BNI5|S000005110|Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
YFL027C	0.771677	PBF2	YFL027C|GYP8|S000001867|GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YLR028C	0.770409	PBF2	YLR028C|ADE16|S000004018|Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YPR173C	0.765847	PBF2	YPR173C|VPS4|S000006377|AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism
YPR035W	0.76326	PBF2	YPR035W|GLN1|S000006239|Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
YBR093C	0.760924	PBF2	YBR093C|PHO5|S000000297|Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YOR145C	0.758896	PBF2	YOR145C|PNO1|S000005671|Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain
YNL226W	0.756819	PBF2	YNL226W||S000005170|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C
YDL019C	0.755052	PBF2	YDL019C|OSH2|S000002177|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YDR492W	0.747256	PBF2	YDR492W|IZH1|S000002900|Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YNR054C	0.745975	PBF2	YNR054C|ESF2|S000005337|Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YGR030C	0.73928	PBF2	YGR030C|POP6|S000003262|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YJR113C	0.738352	PBF2	YJR113C|RSM7|S000003874|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YLR011W	0.736622	PBF2	YLR011W|LOT6|S000004001|FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YGR084C	0.733554	PBF2	YGR084C|MRP13|S000003316|Mitochondrial ribosomal protein of the small subunit
YIL051C	0.732548	PBF2	YIL051C|MMF1|S000001313|Mitochondrial protein involved in maintenance of the mitochondrial genome
YNL312W	0.729838	PBF2	YNL312W|RFA2|S000005256|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YDR433W	0.727887	PBF2	YDR433W||S000002841|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL169C	0.719265	PBF2	YIL169C||S000001431|Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YMR266W	0.717634	PBF2	YMR266W|RSN1|S000004879|Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YIR010W	0.715533	PBF2	YIR010W|DSN1|S000001449|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
YER135C	0.712038	PBF2	YER135C||S000000937|Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene
YJL072C	0.710803	PBF2	YJL072C|PSF2|S000003608|Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YDR047W	0.710499	PBF2	YDR047W|HEM12|S000002454|Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YMR108W	0.704287	PBF2	YMR108W|ILV2|S000004714|Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YMR211W	0.702949	PBF2	YMR211W|DML1|S000004824|Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YGR116W	0.702751	PBF2	YGR116W|SPT6|S000003348|Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
YGR177C	0.701614	PBF2	YGR177C|ATF2|S000003409|Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YHL002C-A	0.698524	PBF2	YHL002C-A||S000028770|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL028W	0.692737	PBF2	YLL028W|TPO1|S000003951|Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YER182W	0.692601	PBF2	YER182W|FMP10|S000000984|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL026W	0.689645	PBF2	YBL026W|LSM2|S000000122|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YER002W	0.679151	PBF2	YER002W|NOP16|S000000804|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YMR036C	0.675208	PBF2	YMR036C|MIH1|S000004639|Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
YCL050C	0.674781	PBF2	YCL050C|APA1|S000000555|Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YJL098W	0.660522	PBF2	YJL098W|SAP185|S000003634|Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
YHR062C	0.657827	PBF2	YHR062C|RPP1|S000001104|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YOR251C	0.656898	PBF2	YOR251C||S000005777|Putative protein of unknown function with similarity to human thiosulfate sulfurtransferase, an enzyme that catalyzes the transfer of sulfur from thiosulfate to cyanide, forming sulfite and thiocyanate; YOR251C is a non-essential gene
YER025W	0.654722	PBF2	YER025W|GCD11|S000000827|Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
YDR088C	0.65199	PBF2	YDR088C|SLU7|S000002495|RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YLR452C	0.642835	PBF2	YLR452C|SST2|S000004444|GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
YDL201W	0.642086	PBF2	YDL201W|TRM8|S000002360|Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YHL038C	0.637076	PBF2	YHL038C|CBP2|S000001030|Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
YMR059W	0.635761	PBF2	YMR059W|SEN15|S000004663|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
YGL257C	0.632016	PBF2	YGL257C|MNT2|S000003226|Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
YGL202W	0.629939	PBF2	YGL202W|ARO8|S000003170|Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YHR179W	0.629777	PBF2	YHR179W|OYE2|S000001222|Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YOL092W	0.628396	PBF2	YOL092W||S000005452|Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype
YLR145W	0.627614	PBF2	YLR145W|RMP1|S000004135|Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
YLR083C	0.627493	PBF2	YLR083C|EMP70|S000004073|Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions
YHR005C	0.626431	PBF2	YHR005C|GPA1|S000001047|GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
YLR443W	0.625196	PBF2	YLR443W|ECM7|S000004435|Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency
YCR099C	0.624644	PBF2	YCR099C||S000000696|Putative protein of unknown function
YGR152C	0.62383	PBF2	YGR152C|RSR1|S000003384|GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YHR127W	0.621187	PBF2	YHR127W||S000001169|Protein of unknown function; localizes to the nucleus
YIL126W	0.612591	PBF2	YIL126W|STH1|S000001388|ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YMR153W	0.607397	PBF2	YMR153W|NUP53|S000004762|Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex
YMR106C	0.607312	PBF2	YMR106C|YKU80|S000004712|Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YER130C	0.601448	PBF2	YER130C||S000000932|Hypothetical protein
YDL211C	0.600716	PBF2	YDL211C||S000002370|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YLR220W	0.600366	PBF2	YLR220W|CCC1|S000004210|Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation
YHL002W	0.599157	PBF2	YHL002W|HSE1|S000000994|Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YMR298W	0.598293	PBF2	YMR298W|LIP1|S000004913|Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
YGR217W	0.597057	PBF2	YGR217W|CCH1|S000003449|Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
YBR219C	0.591222	PBF2	YBR219C||S000000423|Putative protein of unknown function; YBR219C is not an essential gene
YBL041W	0.590953	PBF2	YBL041W|PRE7|S000000137|Beta 6 subunit of the 20S proteasome
YDR073W	0.584429	PBF2	YDR073W|SNF11|S000002480|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YMR288W	0.583948	PBF2	YMR288W|HSH155|S000004901|U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
YDR321W	0.58155	PBF2	YDR321W|ASP1|S000002729|Cytosolic L-asparaginase, involved in asparagine catabolism
YKR031C	0.579181	PBF2	YKR031C|SPO14|S000001739|Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis
YEL027W	0.56914	PBF2	YEL027W|CUP5|S000000753|Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YDR206W	0.56202	PBF2	YDR206W|EBS1|S000002614|Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
YOR130C	0.561934	PBF2	YOR130C|ORT1|S000005656|Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YHR036W	0.558275	PBF2	YHR036W|BRL1|S000001078|Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
YIR042C	0.557979	PBF2	YIR042C||S000001481|Putative protein of unknown function; YIR042C is a non-essential gene
YCR015C	0.557678	PBF2	YCR015C||S000000608|Putative protein of unknown function; YCR015C is not an essential gene
YHR120W	0.557581	PBF2	YHR120W|MSH1|S000001162|DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
YLR389C	0.552563	PBF2	YLR389C|STE23|S000004381|Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family
YDR299W	0.552511	PBF2	YDR299W|BFR2|S000002707|Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A
YDR498C	0.544174	PBF2	YDR498C|SEC20|S000002906|Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p
YJL212C	0.542813	PBF2	YJL212C|OPT1|S000003748|Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YGL012W	0.540687	PBF2	YGL012W|ERG4|S000002980|C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YNL304W	0.540022	PBF2	YNL304W|YPT11|S000005248|Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells
YEL029C	0.535969	PBF2	YEL029C|BUD16|S000000755|Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YER109C	0.531092	PBF2	YER109C|FLO8|S000000911|Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YKL001C	0.530762	PBF2	YKL001C|MET14|S000001484|Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YPL028W	0.528672	PBF2	YPL028W|ERG10|S000005949|Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YLL048C	0.525549	PBF2	YLL048C|YBT1|S000003971|Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters
YGL050W	0.525541	PBF2	YGL050W|TYW3|S000003018|tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YHR162W	0.524319	PBF2	YHR162W||S000001205|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YLR056W	0.523938	PBF2	YLR056W|ERG3|S000004046|C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YEL036C	0.523698	PBF2	YEL036C|ANP1|S000000762|Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
YOL152W	0.523333	PBF2	YOL152W|FRE7|S000005512|Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YBL014C	0.5231	PBF2	YBL014C|RRN6|S000000110|Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein
YPR194C	0.521597	PBF2	YPR194C|OPT2|S000006398|Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans
YLR404W	0.520479	PBF2	YLR404W|FLD1|S000004396|Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
YJR024C	0.51971	PBF2	YJR024C|MDE1|S000003785|Putative methylthio-ribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant
YLR099W-A	0.519646	PBF2	YLR099W-A||S000007618|Putative protein of unknown function
YJR112W	0.51838	PBF2	YJR112W|NNF1|S000003873|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YAL019W	0.517925	PBF2	YAL019W|FUN30|S000000017|Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR268C	0.515519	PBF2	YMR268C|PRP24|S000004881|Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
YDR274C	0.513269	PBF2	YDR274C||S000002682|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR152W	0.510592	PBF2	YDR152W|GIR2|S000002559|Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)
YPR142C	0.510344	PBF2	YPR142C||S000006346|Hypothetical protein; open reading frame overlaps 5' end of essential RRP15 gene required for ribosomal RNA processing
YLR421C	0.508827	PBF2	YLR421C|RPN13|S000004413|Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome
YOR107W	0.508579	PBF2	YOR107W|RGS2|S000005633|Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YJR099W	0.507415	PBF2	YJR099W|YUH1|S000003860|Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YFR020W	0.506622	PBF2	YFR020W||S000001916|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL006C	0.505976	PBF2	YJL006C|CTK2|S000003543|Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins
YPL041C	0.504319	PBF2	YPL041C||S000005962|Protein of unknown function involved in maintenance of proper telomere length
YGR189C	0.500913	PBF2	YGR189C|CRH1|S000003421|Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YLR013W	0.496945	PBF2	YLR013W|GAT3|S000004003|Protein containing GATA family zinc finger motifs
YBL068W	0.494923	PBF2	YBL068W|PRS4|S000000164|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YPR063C	0.493405	PBF2	YPR063C||S000006267|ER-localized protein of unknown function
YHR187W	0.492629	PBF2	YHR187W|IKI1|S000001230|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
YGL060W	0.490607	PBF2	YGL060W|YBP2|S000003028|Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p
YGL115W	0.488334	PBF2	YGL115W|SNF4|S000003083|Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
YKL013C	0.488146	PBF2	YKL013C|ARC19|S000001496|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YLR266C	0.485545	PBF2	YLR266C|PDR8|S000004256|Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YJR104C	0.482366	PBF2	YJR104C|SOD1|S000003865|Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YGL069C	0.479951	PBF2	YGL069C||S000003037|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
YLR042C	0.476489	PBF2	YLR042C||S000004032|Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YCL001W	0.476112	PBF2	YCL001W|RER1|S000000507|Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
YNR067C	0.475395	PBF2	YNR067C|DSE4|S000005350|Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YDR414C	0.474662	PBF2	YDR414C|ERD1|S000002822|Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
YIL137C	0.474051	PBF2	YIL137C|TMA108|S000001399|Protein that associates with ribosomes; putative metalloprotease
YNL323W	0.472258	PBF2	YNL323W|LEM3|S000005267|Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
YOR030W	0.469573	PBF2	YOR030W|DFG16|S000005556|Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YDR094W	0.468796	PBF2	YDR094W||S000002501|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YEL045C	0.465682	PBF2	YEL045C||S000000771|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YDR095C	0.463839	PBF2	YDR095C||S000002502|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL038C	0.461217	PBF2	YGL038C|OCH1|S000003006|Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
YBR263W	0.460698	PBF2	YBR263W|SHM1|S000000467|Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
YJR133W	0.459364	PBF2	YJR133W|XPT1|S000003894|Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
YAL035W	0.458788	PBF2	YAL035W|FUN12|S000000033|GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
YDR155C	0.456813	PBF2	YDR155C|CPR1|S000002562|Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YOR233W	0.455317	PBF2	YOR233W|KIN4|S000005759|Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck
YGR031W	0.452573	PBF2	YGR031W||S000003263|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL136W	0.450399	PBF2	YPL136W||S000006057|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
YDR123C	0.447084	PBF2	YDR123C|INO2|S000002530|Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
YGL194C-A	0.447041	PBF2	YGL194C-A||S000087160|Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
YGL247W	0.446176	PBF2	YGL247W|BRR6|S000003216|Essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores
YDR303C	0.445119	PBF2	YDR303C|RSC3|S000002711|Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
YDR109C	0.44331	PBF2	YDR109C||S000002516|Putative kinase
YDR179W-A	0.443259	PBF2	YDR179W-A||S000002587|Putative protein of unknown function
YAR008W	0.439275	PBF2	YAR008W|SEN34|S000000066|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YHR026W	0.438803	PBF2	YHR026W|PPA1|S000001068|Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
YJL107C	0.438345	PBF2	YJL107C||S000003643|Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YLR412C-A	0.435208	PBF2	YLR412C-A||S000028572|Putative protein of unknown function
YPR143W	0.432829	PBF2	YPR143W|RRP15|S000006347|Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
YCL018W	0.432383	PBF2	YCL018W|LEU2|S000000523|Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YHR137W	0.430989	PBF2	YHR137W|ARO9|S000001179|Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YGR001C	0.430032	PBF2	YGR001C|AML1|S000003233|Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae
YML072C	0.429235	PBF2	YML072C|TCB3|S000004537|Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact
YOL142W	0.427771	PBF2	YOL142W|RRP40|S000005502|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YFR052W	0.423076	PBF2	YFR052W|RPN12|S000001948|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
YOL021C	0.417939	PBF2	YOL021C|DIS3|S000005381|Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family
YEL031W	0.415429	PBF2	YEL031W|SPF1|S000000757|P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
YIL130W	0.412103	PBF2	YIL130W|ASG1|S000001392|Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins
YGR114C	0.410129	PBF2	YGR114C||S000003346|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YNL189W	0.410114	PBF2	YNL189W|SRP1|S000005133|Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YOL161C	0.406293	PBF2	YOL161C|PAU20|S000005521|Hypothetical protein
YGL061C	0.400855	PBF2	YGL061C|DUO1|S000003029|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YPL011C	0.400271	PBF2	YPL011C|TAF3|S000005932|TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
YPL047W	0.394289	PBF2	YPL047W|SGF11|S000005968|Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
YLR089C	0.39314	PBF2	YLR089C|ALT1|S000004079|Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR008C	0.390913	PBF2	YDR008C||S000002415|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR014C	0.390273	PBF2	YAR014C|BUD14|S000000069|Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YEL046C	0.387779	PBF2	YEL046C|GLY1|S000000772|Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YKL216W	0.387002	PBF2	YKL216W|URA1|S000001699|Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YBR271W	0.381231	PBF2	YBR271W||S000000475|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene
YLR163C	0.379767	PBF2	YLR163C|MAS1|S000004153|Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YMR285C	0.376118	PBF2	YMR285C|NGL2|S000004898|Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p
YMR129W	0.370883	PBF2	YMR129W|POM152|S000004736|Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase;
YGL155W	0.36877	PBF2	YGL155W|CDC43|S000003123|Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
YNL279W	0.367865	PBF2	YNL279W|PRM1|S000005223|Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
YDL039C	0.367487	PBF2	YDL039C|PRM7|S000002197|Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
YNL221C	0.366961	PBF2	YNL221C|POP1|S000005165|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P
YDR188W	0.363741	PBF2	YDR188W|CCT6|S000002596|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
YBR058C-A	0.362963	PBF2	YBR058C-A|TSC3|S000007521|Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YOR185C	0.360258	PBF2	YOR185C|GSP2|S000005711|GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability
YDR284C	0.360146	PBF2	YDR284C|DPP1|S000002692|Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism
YML094C-A	0.359131	PBF2	YML094C-A||S000004561|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
YOR362C	0.358964	PBF2	YOR362C|PRE10|S000005889|Alpha 7 subunit of the 20S proteasome
YBR153W	0.356945	PBF2	YBR153W|RIB7|S000000357|Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
YIR031C	0.355789	PBF2	YIR031C|DAL7|S000001470|Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YDR499W	0.353888	PBF2	YDR499W|LCD1|S000002907|Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP
YAL044C	0.353464	PBF2	YAL044C|GCV3|S000000042|H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YJL180C	0.345601	PBF2	YJL180C|ATP12|S000003716|Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
YML108W	0.345399	PBF2	YML108W||S000004576|Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene
YDR046C	0.34492	PBF2	YDR046C|BAP3|S000002453|Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YDL024C	0.343087	PBF2	YDL024C|DIA3|S000002182|Protein of unknown function, involved in invasive and pseudohyphal growth
YBR049C	0.340231	PBF2	YBR049C|REB1|S000000253|RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription
YIL046W-A	0.339302	PBF2	YIL046W-A||S000028836|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YOL061W	0.336892	PBF2	YOL061W|PRS5|S000005422|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YDR089W	0.336056	PBF2	YDR089W||S000002496|Protein of unknown function; deletion confers resistance to Nickel
YJL106W	0.331249	PBF2	YJL106W|IME2|S000003642|Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YDL058W	0.330845	PBF2	YDL058W|USO1|S000002216|Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex
YBR162C	0.327941	PBF2	YBR162C|TOS1|S000000366|Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YHR049W	0.324924	PBF2	YHR049W|FSH1|S000001091|Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p
YML015C	0.324447	PBF2	YML015C|TAF11|S000004477|TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YOL145C	0.322687	PBF2	YOL145C|CTR9|S000005505|Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats
YBL046W	0.322181	PBF2	YBL046W|PSY4|S000000142|Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus
YGR083C	0.317352	PBF2	YGR083C|GCD2|S000003315|Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YBL104C	0.315593	PBF2	YBL104C||S000000200|Putative protein of unknown function, promoter contains multiple GCN4 binding sites
YOR056C	0.314078	PBF2	YOR056C|NOB1|S000005582|Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA
YKL201C	0.31362	PBF2	YKL201C|MNN4|S000001684|Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
YJR072C	0.313345	PBF2	YJR072C|NPA3|S000003833|Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex
YDR187C	0.312753	PBF2	YDR187C||S000002595|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
YEL042W	0.31134	PBF2	YEL042W|GDA1|S000000768|Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
YAL040C	0.309046	PBF2	YAL040C|CLN3|S000000038|G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis
YGR218W	0.305524	PBF2	YGR218W|CRM1|S000003450|Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
YDR292C	0.304287	PBF2	YDR292C|SRP101|S000002700|Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
YPL175W	0.299891	PBF2	YPL175W|SPT14|S000006096|UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
YBL053W	0.299702	PBF2	YBL053W||S000000149|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR198C	0.29928	PBF2	YDR198C|RKM2|S000002606|Ribosomal protein lysine methyltransferase, responsible for epsilon-trimethylation of the lysine residue at position 10 of Rpl12Ap and Rpl12Bp
YOL007C	0.293747	PBF2	YOL007C|CSI2|S000005367|Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
YNL338W	0.290946	PBF2	YNL338W||S000005282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YDL242W	0.288431	PBF2	YDL242W||S000002401|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR223C	0.286166	PBF2	YLR223C|IFH1|S000004213|Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate
YLR400W	0.284324	PBF2	YLR400W||S000004392|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL092W	0.281934	PBF2	YGL092W|NUP145|S000003060|Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p
YDR364C	0.280311	PBF2	YDR364C|CDC40|S000002772|Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats
YGR097W	0.279137	PBF2	YGR097W|ASK10|S000003329|Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YLR099C	0.271597	PBF2	YLR099C|ICT1|S000004089|Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress
YJL041W	0.269502	PBF2	YJL041W|NSP1|S000003577|Essential component of the nuclear pore complex, which mediates nuclear import and export
YDR241W	0.26804	PBF2	YDR241W|BUD26|S000002649|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YLR319C	0.266344	PBF2	YLR319C|BUD6|S000004311|Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
YER092W	0.265089	PBF2	YER092W|IES5|S000000894|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YJL074C	0.264256	PBF2	YJL074C|SMC3|S000003610|Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
YOR043W	0.263874	PBF2	YOR043W|WHI2|S000005569|Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YML007W	0.26325	PBF2	YML007W|YAP1|S000004466|Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium
YLR012C	0.262473	PBF2	YLR012C||S000004002|Putative protein of unknown function; YLR012C is not an essential gene
YPR183W	0.261218	PBF2	YPR183W|DPM1|S000006387|Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
YLR039C	0.258722	PBF2	YLR039C|RIC1|S000004029|Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
YAL056C-A	0.257956	PBF2	YAL056C-A||S000002139|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER089C	0.253743	PBF2	YER089C|PTC2|S000000891|Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation
YKR095W-A	0.25343	PBF2	YKR095W-A|PCC1|S000028512|Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens
YDR349C	0.253045	PBF2	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YLL031C	0.252916	PBF2	YLL031C|GPI13|S000003954|ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
YLR044C	0.250438	PBF2	YLR044C|PDC1|S000004034|Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
YKL101W	0.249208	PBF2	YKL101W|HSL1|S000001584|Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YJL091C	0.246088	PBF2	YJL091C|GWT1|S000003627|Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YBR300C	0.23962	PBF2	YBR300C||S000000504|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YFL056C	0.237474	PBF2	YFL056C|AAD6|S000001838|Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YBR201W	0.234396	PBF2	YBR201W|DER1|S000000405|Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
YNL218W	0.233836	PBF2	YNL218W|MGS1|S000005162|Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)
YJR094C	0.232781	PBF2	YJR094C|IME1|S000003854|Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YDR300C	0.229933	PBF2	YDR300C|PRO1|S000002708|Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis
YOL030W	0.228959	PBF2	YOL030W|GAS5|S000005390|1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YIR023W	0.228586	PBF2	YIR023W|DAL81|S000001462|Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YIL134W	0.227659	PBF2	YIL134W|FLX1|S000001396|Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane
YPL132W	0.227134	PBF2	YPL132W|COX11|S000006053|Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
YOR058C	0.226665	PBF2	YOR058C|ASE1|S000005584|Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate
YCR090C	0.224892	PBF2	YCR090C||S000000686|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
YEL025C	0.222588	PBF2	YEL025C||S000000751|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YBR024W	0.222541	PBF2	YBR024W|SCO2|S000000228|Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YLR255C	0.22155	PBF2	YLR255C||S000004245|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR478W	0.219461	PBF2	YDR478W|SNM1|S000002886|Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YMR067C	0.218572	PBF2	YMR067C|UBX4|S000004671|UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YJR111C	0.217194	PBF2	YJR111C||S000003872|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
YJR055W	0.215584	PBF2	YJR055W|HIT1|S000003816|Protein of unknown function, required for growth at high temperature
YLR227C	0.214744	PBF2	YLR227C|ADY4|S000004217|Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YJR098C	0.212846	PBF2	YJR098C||S000003859|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL057C	0.212183	PBF2	YEL057C||S000000783|Protein of unknown function involved in telomere maintenance; target of UME6 regulation
YJL073W	0.210547	PBF2	YJL073W|JEM1|S000003609|DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
YKL047W	0.20683	PBF2	YKL047W||S000001530|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YMR043W	0.205735	PBF2	YMR043W|MCM1|S000004646|Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
YHR098C	0.205628	PBF2	YHR098C|SFB3|S000001140|Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate
YKL186C	0.204894	PBF2	YKL186C|MTR2|S000001669|mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
YDL059C	0.203597	PBF2	YDL059C|RAD59|S000002217|Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
YER114C	0.203339	PBF2	YER114C|BOI2|S000000916|Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YML038C	0.202936	PBF2	YML038C|YMD8|S000004502|Putative nucleotide sugar transporter, has similarity to Vrg4p
YGL113W	0.201958	PBF2	YGL113W|SLD3|S000003081|Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p
YOR317W	0.19884	PBF2	YOR317W|FAA1|S000005844|Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YJL147C	0.195436	PBF2	YJL147C||S000003683|Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
YOR052C	0.191858	PBF2	YOR052C||S000005578|Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid
YJL058C	0.19082	PBF2	YJL058C|BIT61|S000003594|Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity
YPR092W	0.18758	PBF2	YPR092W||S000006296|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR298C	0.187413	PBF2	YLR298C|YHC1|S000004289|Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site
YIR038C	0.187176	PBF2	YIR038C|GTT1|S000001477|ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
YDR100W	0.178253	PBF2	YDR100W|TVP15|S000002507|Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YOL020W	0.177573	PBF2	YOL020W|TAT2|S000005380|High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
YJR139C	0.177378	PBF2	YJR139C|HOM6|S000003900|Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
YBL021C	0.17536	PBF2	YBL021C|HAP3|S000000117|Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
YOR316C-A	0.174931	PBF2	YOR316C-A||S000028584|Putative protein of unknown function; identified by fungal homology and RT-PCR
YKR080W	0.171033	PBF2	YKR080W|MTD1|S000001788|NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
YBR053C	0.168381	PBF2	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YKL012W	0.167981	PBF2	YKL012W|PRP40|S000001495|U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
YLR090W	0.165854	PBF2	YLR090W|XDJ1|S000004080|Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR076W	0.165323	PBF2	YHR076W|PTC7|S000001118|Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YMR016C	0.165318	PBF2	YMR016C|SOK2|S000004618|Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YIL061C	0.165034	PBF2	YIL061C|SNP1|S000001323|Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein
YPR091C	0.15917	PBF2	YPR091C||S000006295|Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene
YMR086C-A	0.158504	PBF2	YMR086C-A||S000004691|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR414C	0.156889	PBF2	YLR414C||S000004406|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud and cytoplasm; Hog1p is required for transcriptional induction in response to cell wall damage; YLR414C is not an essential gene
YIL025C	0.15634	PBF2	YIL025C||S000001287|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR072C-A	0.156011	PBF2	YBR072C-A||S000028532|Putative protein of unknown function; identified by fungal homology and RT-PCR
YMR207C	0.155972	PBF2	YMR207C|HFA1|S000004820|Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis
YLR081W	0.155751	PBF2	YLR081W|GAL2|S000004071|Galactose permease, required for utilization of galactose; also able to transport glucose
YBR073W	0.154996	PBF2	YBR073W|RDH54|S000000277|DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference
YIL030C	0.152537	PBF2	YIL030C|SSM4|S000001292|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
YBR176W	0.149976	PBF2	YBR176W|ECM31|S000000380|Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
YGR049W	0.149765	PBF2	YGR049W|SCM4|S000003281|Potential regulatory effector of CDC4 function, suppresses a temperature-sensitive allele of CDC4, tripartite protein structure in which a charged region separates two uncharged domains, not essential for mitosis or meiosis
YDL126C	0.147701	PBF2	YDL126C|CDC48|S000002284|ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
YBR068C	0.147229	PBF2	YBR068C|BAP2|S000000272|High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains
YGL125W	0.145499	PBF2	YGL125W|MET13|S000003093|Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YBL108W	0.143392	PBF2	YBL108W||S000000204|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL171C	0.139778	PBF2	YDL171C|GLT1|S000002330|NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YPL251W	0.139102	PBF2	YPL251W||S000006172|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
YNL191W	0.138829	PBF2	YNL191W|DUG3|S000005135|Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YLR120C	0.13871	PBF2	YLR120C|YPS1|S000004110|Aspartic protease, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YGL178W	0.13862	PBF2	YGL178W|MPT5|S000003146|Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
YBR119W	0.132079	PBF2	YBR119W|MUD1|S000000323|U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
YKL113C	0.131932	PBF2	YKL113C|RAD27|S000001596|5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
YMR265C	0.129836	PBF2	YMR265C||S000004878|Putative protein of unknown function
YHR059W	0.129372	PBF2	YHR059W|FYV4|S000001101|Protein of unknown function, required for survival upon exposure to K1 killer toxin
YCR098C	0.129062	PBF2	YCR098C|GIT1|S000000695|Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YBR220C	0.127087	PBF2	YBR220C||S000000424|Putative protein of unknown function; YBR220C is not an essential gene
YNL021W	0.125878	PBF2	YNL021W|HDA1|S000004966|Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation
YGL088W	0.12054	PBF2	YGL088W||S000003056|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YLR376C	0.118297	PBF2	YLR376C|PSY3|S000004368|Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
YJR116W	0.1166	PBF2	YJR116W||S000003877|Putative protein of unknown function
YOR394C-A	0.115547	PBF2	YOR394C-A||S000028718|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR162W-A	0.113904	PBF2	YBR162W-A|YSY6|S000002158|Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
YJL128C	0.112674	PBF2	YJL128C|PBS2|S000003664|MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition
YBR044C	0.112437	PBF2	YBR044C|TCM62|S000000248|Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YHR103W	0.111808	PBF2	YHR103W|SBE22|S000001145|Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
YBR155W	0.108364	PBF2	YBR155W|CNS1|S000000359|TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
YMR062C	0.106974	PBF2	YMR062C|ECM40|S000004666|Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YDR026C	0.105967	PBF2	YDR026C||S000002433|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p
YGR154C	0.105764	PBF2	YGR154C|GTO1|S000003386|Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
YCL010C	0.0964963	PBF2	YCL010C|SGF29|S000000516|SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex
YHR047C	0.0938024	PBF2	YHR047C|AAP1|S000001089|Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YOR012W	0.0895706	PBF2	YOR012W||S000005538|Putative protein of unknown function
YLR380W	0.0888416	PBF2	YLR380W|CSR1|S000004372|Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
YAR007C	0.0878599	PBF2	YAR007C|RFA1|S000000065|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YMR008C	0.0874594	PBF2	YMR008C|PLB1|S000004610|Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YBR157C	0.0863639	PBF2	YBR157C|ICS2|S000000361|Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YJR058C	0.0817801	PBF2	YJR058C|APS2|S000003819|Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
YGL025C	0.0778749	PBF2	YGL025C|PGD1|S000002993|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
YGL056C	0.077829	PBF2	YGL056C|SDS23|S000003024|One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YBL061C	0.0761994	PBF2	YBL061C|SKT5|S000000157|Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation
YNL228W	0.067658	PBF2	YNL228W||S000005172|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
YGR198W	0.0671274	PBF2	YGR198W|YPP1|S000003430|Cargo-transport protein involved in endocytosis; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene
YJL211C	0.0618421	PBF2	YJL211C||S000003747|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2
YNL049C	0.0605851	PBF2	YNL049C|SFB2|S000004994|Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy
YGL107C	0.0598834	PBF2	YGL107C|RMD9|S000003075|Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
YGR178C	0.0585546	PBF2	YGR178C|PBP1|S000003410|Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
YKL208W	0.0571011	PBF2	YKL208W|CBT1|S000001691|Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
YAR015W	0.0559923	PBF2	YAR015W|ADE1|S000000070|N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
YDR081C	0.0557776	PBF2	YDR081C|PDC2|S000002488|Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes
YKL048C	0.0552832	PBF2	YKL048C|ELM1|S000001531|Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
YOR267C	0.0544737	PBF2	YOR267C|HRK1|S000005793|Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
YDR327W	0.0544183	PBF2	YDR327W||S000002735|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1
YLR010C	0.0538341	PBF2	YLR010C|TEN1|S000004000|Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YNL227C	0.0537567	PBF2	YNL227C|JJJ1|S000005171|Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
YOR195W	0.0517227	PBF2	YOR195W|SLK19|S000005721|Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate
YKL185W	0.048327	PBF2	YKL185W|ASH1|S000001668|Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
YPR121W	0.0479972	PBF2	YPR121W|THI22|S000006325|Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YGR134W	0.0445476	PBF2	YGR134W|CAF130|S000003366|Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YBR301W	0.044456	PBF2	YBR301W|DAN3|S000000505|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YKR052C	0.0432947	PBF2	YKR052C|MRS4|S000001760|Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YNL068C	0.0418712	PBF2	YNL068C|FKH2|S000005012|Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
YNR070W	0.0416434	PBF2	YNR070W||S000005353|Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFR013W	0.0405272	PBF2	YFR013W|IOC3|S000001909|Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing
YPL252C	0.0402776	PBF2	YPL252C|YAH1|S000006173|Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
YNR005C	0.0380033	PBF2	YNR005C||S000005288|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL186W	0.03724	PBF2	YNL186W|UBP10|S000005130|Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
YIL029W-A	0.036293	PBF2	YIL029W-A||S000028788|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER068W	0.0321785	PBF2	YER068W|MOT2|S000000870|Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
YNR014W	0.0317641	PBF2	YNR014W||S000005297|Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YPR105C	0.0310189	PBF2	YPR105C|COG4|S000006309|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YML113W	0.0279259	PBF2	YML113W|DAT1|S000004581|DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
YIL026C	0.0264556	PBF2	YIL026C|IRR1|S000001288|Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YKL068W	0.0252898	PBF2	YKL068W|NUP100|S000001551|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
YHR093W	0.0241366	PBF2	YHR093W|AHT1|S000001135|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region
YHR027C	0.024133	PBF2	YHR027C|RPN1|S000001069|Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions
YGR231C	0.0240852	PBF2	YGR231C|PHB2|S000003463|Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YOR196C	0.0230132	PBF2	YOR196C|LIP5|S000005722|Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
YDR521W	0.0222787	PBF2	YDR521W||S000002929|Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
YJR132W	0.0188591	PBF2	YJR132W|NMD5|S000003893|Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog
YLR288C	0.0147107	PBF2	YLR288C|MEC3|S000004279|DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1
YGL177W	0.0146346	PBF2	YGL177W||S000003145|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR197W	0.0142593	PBF2	YOR197W|MCA1|S000005723|Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment
YNL181W	0.0134828	PBF2	YNL181W||S000005125|Putative oxidoreductase; required for cell viability
YLR390W	0.0118691	PBF2	YLR390W|ECM19|S000004382|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR028W	0.0105233	PBF2	YKR028W|SAP190|S000001736|Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p
YJL055W	0.00865922	PBF2	YJL055W||S000003591|Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU
YDL117W	0.00566636	PBF2	YDL117W|CYK3|S000002275|SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
YNL073W	0.00522095	PBF2	YNL073W|MSK1|S000005017|Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria
YHR122W	0.00347708	PBF2	YHR122W||S000001164|Protein of unknown function required for establishment of sister chromatid cohesion; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene
YJR129C	0.00196694	PBF2	YJR129C||S000003890|Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR439W	0.000879915	PBF2	YDR439W|LRS4|S000002847|Protein involved in rDNA silencing; positively charged coiled-coil protein with limited similarity to myosin
