YFR055W	27.8353	PBF1	YFR055W|IRC7|S000001952|Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YOR101W	25.7974	PBF1	YOR101W|RAS1|S000005627|GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YFR056C	24.0481	PBF1	YFR056C||S000001951|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YER073W	21.0946	PBF1	YER073W|ALD5|S000000875|Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YOR096W	19.0634	PBF1	YOR096W|RPS7A|S000005622|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YKR092C	18.8103	PBF1	YKR092C|SRP40|S000001800|Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YOR340C	17.1302	PBF1	YOR340C|RPA43|S000005867|RNA polymerase I subunit A43
YGR251W	16.95	PBF1	YGR251W||S000003483|Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YIR021W	15.4202	PBF1	YIR021W|MRS1|S000001460|Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YDL148C	15.3043	PBF1	YDL148C|NOP14|S000002307|Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YLR196W	14.7364	PBF1	YLR196W|PWP1|S000004186|Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily
YLR009W	14.7126	PBF1	YLR009W|RLP24|S000003999|Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis
YDL208W	14.3975	PBF1	YDL208W|NHP2|S000002367|Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing
YML043C	14.2925	PBF1	YML043C|RRN11|S000004507|Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YPL211W	13.7076	PBF1	YPL211W|NIP7|S000006132|Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p
YPR148C	13.6323	PBF1	YPR148C||S000006352|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YLR062C	13.4702	PBF1	YLR062C|BUD28|S000004052|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YER137C	13.4375	PBF1	YER137C||S000000939|Putative protein of unknown function
YPL143W	12.8575	PBF1	YPL143W|RPL33A|S000006064|N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YGR128C	12.7102	PBF1	YGR128C|UTP8|S000003360|Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YLR355C	12.4674	PBF1	YLR355C|ILV5|S000004347|Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YNL112W	12.2424	PBF1	YNL112W|DBP2|S000005056|Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
YHR128W	12.1845	PBF1	YHR128W|FUR1|S000001170|Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YNL248C	11.9393	PBF1	YNL248C|RPA49|S000005192|RNA polymerase I subunit A49
YJL010C	11.7256	PBF1	YJL010C|NOP9|S000003547|Essential component of pre-40S ribosomes that is required for early cleavages of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats
YML123C	11.5558	PBF1	YML123C|PHO84|S000004592|High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YDL023C	11.462	PBF1	YDL023C||S000002181|Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YER146W	11.183	PBF1	YER146W|LSM5|S000000948|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YDL051W	11.1559	PBF1	YDL051W|LHP1|S000002209|RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YDL055C	11.1508	PBF1	YDL055C|PSA1|S000002213|GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YDL022C-A	11.1217	PBF1	YDL022C-A||S000028537|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YIL118W	11.0852	PBF1	YIL118W|RHO3|S000001380|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YNL141W	10.9742	PBF1	YNL141W|AAH1|S000005085|Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YOR004W	10.8901	PBF1	YOR004W|UTP23|S000005530|Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YGR086C	10.8894	PBF1	YGR086C|PIL1|S000003318|Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YER074W	10.699	PBF1	YER074W|RPS24A|S000000876|Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YGR123C	10.6848	PBF1	YGR123C|PPT1|S000003355|Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YMR290C	10.6376	PBF1	YMR290C|HAS1|S000004903|ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YLR432W	10.5238	PBF1	YLR432W|IMD3|S000004424|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YMR290W-A	10.421	PBF1	YMR290W-A||S000004904|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YNL178W	10.4209	PBF1	YNL178W|RPS3|S000005122|Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YJL122W	10.3065	PBF1	YJL122W|ALB1|S000003658|Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YBL027W	10.1524	PBF1	YBL027W|RPL19B|S000000123|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YBR126W-A	10.1266	PBF1	YBR126W-A||S000028600|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YBR154C	10.1013	PBF1	YBR154C|RPB5|S000000358|RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YBL039C	10.0449	PBF1	YBL039C|URA7|S000000135|Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YKL078W	9.98019	PBF1	YKL078W|DHR2|S000001561|Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
YPL012W	9.97508	PBF1	YPL012W|RRP12|S000005933|Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats
YNL113W	9.9627	PBF1	YNL113W|RPC19|S000005057|RNA polymerase subunit, common to RNA polymerases I and III
YCR018C	9.89228	PBF1	YCR018C|SRD1|S000000611|Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YBL028C	9.81461	PBF1	YBL028C||S000000124|Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YNL110C	9.70532	PBF1	YNL110C|NOP15|S000005054|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YDL022W	9.62986	PBF1	YDL022W|GPD1|S000002180|NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YDL014W	9.55849	PBF1	YDL014W|NOP1|S000002172|Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YOR153W	9.50417	PBF1	YOR153W|PDR5|S000005679|Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YOR272W	9.4974	PBF1	YOR272W|YTM1|S000005798|Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YCL036W	9.43616	PBF1	YCL036W|GFD2|S000000541|Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YOL077C	9.43373	PBF1	YOL077C|BRX1|S000005437|Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif
YKL081W	9.23544	PBF1	YKL081W|TEF4|S000001564|Translation elongation factor EF-1 gamma
YMR131C	9.23093	PBF1	YMR131C|RRB1|S000004738|Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YKR081C	9.20515	PBF1	YKR081C|RPF2|S000001789|Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
YMR049C	9.19478	PBF1	YMR049C|ERB1|S000004652|Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YMR217W	9.14876	PBF1	YMR217W|GUA1|S000004830|GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YPR010C	9.08093	PBF1	YPR010C|RPA135|S000006214|RNA polymerase I subunit A135
YKL009W	9.06422	PBF1	YKL009W|MRT4|S000001492|Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YGR151C	9.05468	PBF1	YGR151C||S000003383|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YJR070C	9.03098	PBF1	YJR070C|LIA1|S000003831|Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YDR465C	8.94031	PBF1	YDR465C|RMT2|S000002873|Arginine methyltransferase; ribosomal protein L12 is a substrate
YML121W	8.93778	PBF1	YML121W|GTR1|S000004590|Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YHR066W	8.80678	PBF1	YHR066W|SSF1|S000001108|Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family
YPL212C	8.78866	PBF1	YPL212C|PUS1|S000006133|tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA
YNL175C	8.76618	PBF1	YNL175C|NOP13|S000005119|Protein of unknown function, localizes to the nucleolus and nucleoplasm; contains an RNA recognition motif (RRM) and has similarity to Nop12p, which is required for processing of pre-18S rRNA
YLR075W	8.6821	PBF1	YLR075W|RPL10|S000004065|Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YOL086C	8.59688	PBF1	YOL086C|ADH1|S000005446|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YOL127W	8.55617	PBF1	YOL127W|RPL25|S000005487|Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YLR413W	8.54139	PBF1	YLR413W||S000004405|Putative protein of unknown function; YLR413W is not an essential gene
YJR071W	8.52439	PBF1	YJR071W||S000003832|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL053W-A	8.48461	PBF1	YEL053W-A||S000028744|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YKL164C	8.38629	PBF1	YKL164C|PIR1|S000001647|O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YFR001W	8.37907	PBF1	YFR001W|LOC1|S000001897|Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YGR124W	8.34808	PBF1	YGR124W|ASN2|S000003356|Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YOR310C	8.33407	PBF1	YOR310C|NOP58|S000005837|Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YIR026C	8.33065	PBF1	YIR026C|YVH1|S000001465|Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatases
YLR068W	8.26946	PBF1	YLR068W|FYV7|S000004058|Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
YNR053C	8.25733	PBF1	YNR053C|NOG2|S000005336|Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
YAL059W	8.24263	PBF1	YAL059W|ECM1|S000000055|Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YOR226C	8.22624	PBF1	YOR226C|ISU2|S000005752|Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YDR087C	8.18788	PBF1	YDR087C|RRP1|S000002494|Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YNL089C	8.07613	PBF1	YNL089C||S000005033|Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins
YGL029W	8.01399	PBF1	YGL029W|CGR1|S000002997|Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress
YLR180W	7.97464	PBF1	YLR180W|SAM1|S000004170|S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YDR399W	7.94853	PBF1	YDR399W|HPT1|S000002807|Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YGR145W	7.92656	PBF1	YGR145W|ENP2|S000003377|Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YJL148W	7.89061	PBF1	YJL148W|RPA34|S000003684|RNA polymerase I subunit A34.5
YGR159C	7.87385	PBF1	YGR159C|NSR1|S000003391|Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YGL055W	7.8465	PBF1	YGL055W|OLE1|S000003023|Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YPL093W	7.81965	PBF1	YPL093W|NOG1|S000006014|Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
YOR108W	7.7628	PBF1	YOR108W|LEU9|S000005634|Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YKL172W	7.75553	PBF1	YKL172W|EBP2|S000001655|Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles
YDR398W	7.74377	PBF1	YDR398W|UTP5|S000002806|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YLR154C	7.69457	PBF1	YLR154C|RNH203|S000004144|Ribonuclease H2 subunit, required for RNase H2 activity
YIL096C	7.64546	PBF1	YIL096C||S000001358|Putative protein of unknown function; associates with precursors of the 60S ribosomal subunit
YOR271C	7.58886	PBF1	YOR271C|FSF1|S000005797|Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YDL150W	7.57937	PBF1	YDL150W|RPC53|S000002309|RNA polymerase III subunit C53
YOL041C	7.5573	PBF1	YOL041C|NOP12|S000005401|Nucleolar protein, required for pre-25S rRNA processing; contains an RNA recognition motif (RRM) and has similarity to Nop13p, Nsr1p, and putative orthologs in Drosophila and S. pombe
YGL078C	7.53473	PBF1	YGL078C|DBP3|S000003046|Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YFL015W-A	7.52416	PBF1	YFL015W-A||S000028765|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR249C	7.52354	PBF1	YBR249C|ARO4|S000000453|3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YHR148W	7.51179	PBF1	YHR148W|IMP3|S000001191|Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA
YGR280C	7.49441	PBF1	YGR280C|PXR1|S000003512|Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YIL091C	7.45096	PBF1	YIL091C||S000001353|Protein required for cell viability
YER102W	7.41525	PBF1	YER102W|RPS8B|S000000904|Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YOR342C	7.38309	PBF1	YOR342C||S000005869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YPL108W	7.37861	PBF1	YPL108W||S000006029|Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDR385W	7.32395	PBF1	YDR385W|EFT2|S000002793|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YOR234C	7.25756	PBF1	YOR234C|RPL33B|S000005760|Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YFL015C	7.25372	PBF1	YFL015C||S000001879|Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YGR103W	7.23381	PBF1	YGR103W|NOP7|S000003335|Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of cell proliferation
YOL124C	7.20566	PBF1	YOL124C|TRM11|S000005484|Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YPL037C	7.08544	PBF1	YPL037C|EGD1|S000005958|Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YKR024C	7.03054	PBF1	YKR024C|DBP7|S000001732|Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis
YCL059C	6.99833	PBF1	YCL059C|KRR1|S000000564|Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
YGL120C	6.99743	PBF1	YGL120C|PRP43|S000003088|RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YOL080C	6.98528	PBF1	YOL080C|REX4|S000005440|Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly
YDR060W	6.96475	PBF1	YDR060W|MAK21|S000002467|Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein
YBL092W	6.92235	PBF1	YBL092W|RPL32|S000000188|Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YJL200C	6.92209	PBF1	YJL200C|ACO2|S000003736|Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YBR126C	6.90882	PBF1	YBR126C|TPS1|S000000330|Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YDL112W	6.88137	PBF1	YDL112W|TRM3|S000002270|2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YBR142W	6.88094	PBF1	YBR142W|MAK5|S000000346|Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YLR409C	6.871	PBF1	YLR409C|UTP21|S000004401|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLR276C	6.86907	PBF1	YLR276C|DBP9|S000004266|ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit
YAL025C	6.85049	PBF1	YAL025C|MAK16|S000000023|Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YGR245C	6.81801	PBF1	YGR245C|SDA1|S000003477|Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YOL079W	6.75505	PBF1	YOL079W||S000005439|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDL062W	6.74241	PBF1	YDL062W||S000002220|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential
YHR089C	6.7277	PBF1	YHR089C|GAR1|S000001131|Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YER126C	6.71432	PBF1	YER126C|NSA2|S000000928|Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YMR123W	6.71395	PBF1	YMR123W|PKR1|S000004730|V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YJL050W	6.68364	PBF1	YJL050W|MTR4|S000003586|Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA
YDR279W	6.65162	PBF1	YDR279W|RNH202|S000002687|Ribonuclease H2 subunit, required for RNase H2 activity
YFR054C	6.65123	PBF1	YFR054C||S000001950|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR120C	6.62614	PBF1	YDR120C|TRM1|S000002527|tRNA methyltransferase, localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments
YLR154W-A	6.62008	PBF1	YLR154W-A||S000028675|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YKL099C	6.61797	PBF1	YKL099C|UTP11|S000001582|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YER001W	6.61769	PBF1	YER001W|MNN1|S000000803|Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YKL096W-A	6.61734	PBF1	YKL096W-A|CWP2|S000001956|Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YKR093W	6.61707	PBF1	YKR093W|PTR2|S000001801|Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YNL247W	6.56172	PBF1	YNL247W||S000005191|Essential protein of unknown function; may interact with ribosomes, based on co-purification experiments
YLR154W-B	6.55767	PBF1	YLR154W-B||S000028563|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YML056C	6.54596	PBF1	YML056C|IMD4|S000004520|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YKR043C	6.50585	PBF1	YKR043C||S000001751|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YNL114C	6.49405	PBF1	YNL114C||S000005058|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
YLL008W	6.45587	PBF1	YLL008W|DRS1|S000003931|Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YDL063C	6.39528	PBF1	YDL063C||S000002221|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL063C is not an essential gene
YKL014C	6.36729	PBF1	YKL014C|URB1|S000001497|Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YNR003C	6.36595	PBF1	YNR003C|RPC34|S000005286|RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YLR129W	6.36431	PBF1	YLR129W|DIP2|S000004119|Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex
YNL002C	6.34651	PBF1	YNL002C|RLP7|S000004947|Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs
YPL086C	6.34234	PBF1	YPL086C|ELP3|S000006007|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
YGR155W	6.33758	PBF1	YGR155W|CYS4|S000003387|Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YJL009W	6.29039	PBF1	YJL009W||S000003546|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
YDL153C	6.28432	PBF1	YDL153C|SAS10|S000002312|Component of the small (ribosomal) subunit (SSU) processosome required for pre-18S rRNa processing; essential nucleolar protein that, when overproduced, disrupts silencing
YOR243C	6.27463	PBF1	YOR243C|PUS7|S000005769|Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates
YLL011W	6.22728	PBF1	YLL011W|SOF1|S000003934|Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
YBR244W	6.22074	PBF1	YBR244W|GPX2|S000000448|Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YHR070C-A	6.20832	PBF1	YHR070C-A||S000028780|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W
YNL130C	6.20717	PBF1	YNL130C|CPT1|S000005074|Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
YCL063W	6.20111	PBF1	YCL063W|VAC17|S000000568|Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YHR052W	6.18564	PBF1	YHR052W|CIC1|S000001094|Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles
YIL056W	6.17047	PBF1	YIL056W|VHR1|S000001318|Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YPR163C	6.1645	PBF1	YPR163C|TIF3|S000006367|Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YOR206W	6.11853	PBF1	YOR206W|NOC2|S000005732|Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YJR097W	6.11339	PBF1	YJR097W|JJJ3|S000003858|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YLR363W-A	6.04321	PBF1	YLR363W-A||S000007620|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YPL239W	6.02726	PBF1	YPL239W|YAR1|S000006160|Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YOR341W	6.02488	PBF1	YOR341W|RPA190|S000005868|RNA polymerase I subunit; largest subunit of RNA polymerase I
YDR101C	6.02201	PBF1	YDR101C|ARX1|S000002508|Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YEL001C	6.01752	PBF1	YEL001C|IRC22|S000000727|Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YHR197W	5.99042	PBF1	YHR197W|RIX1|S000001240|Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YDR450W	5.9677	PBF1	YDR450W|RPS18A|S000002858|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YER049W	5.95604	PBF1	YER049W|TPA1|S000000851|Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YOR026W	5.9379	PBF1	YOR026W|BUB3|S000005552|Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p
YPR074C	5.88146	PBF1	YPR074C|TKL1|S000006278|Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YDR021W	5.87817	PBF1	YDR021W|FAL1|S000002428|Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases
YKL218C	5.86719	PBF1	YKL218C|SRY1|S000001701|3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YHR169W	5.7921	PBF1	YHR169W|DBP8|S000001212|Putative ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 40S ribosomal subunit
YDR361C	5.74688	PBF1	YDR361C|BCP1|S000002769|Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
YDR083W	5.73862	PBF1	YDR083W|RRP8|S000002490|Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation
YGR200C	5.73048	PBF1	YGR200C|ELP2|S000003432|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YFR039C	5.69665	PBF1	YFR039C||S000001935|Putative protein of unknown function; may be involved in response to high salt and changes in carbon source
YBL070C	5.67166	PBF1	YBL070C||S000000166|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL076W	5.64921	PBF1	YOL076W|MDM20|S000005436|Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly
YOR369C	5.63023	PBF1	YOR369C|RPS12|S000005896|Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YCR016W	5.6188	PBF1	YCR016W||S000000609|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YHR144C	5.60377	PBF1	YHR144C|DCD1|S000001187|Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YGL171W	5.60075	PBF1	YGL171W|ROK1|S000003139|ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis
YHR149C	5.59437	PBF1	YHR149C|SKG6|S000001192|Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YGR271C-A	5.58404	PBF1	YGR271C-A|EFG1|S000007608|Protein of unknown function; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YPL266W	5.57538	PBF1	YPL266W|DIM1|S000006187|Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YCL037C	5.55912	PBF1	YCL037C|SRO9|S000000542|Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif
YPL043W	5.54241	PBF1	YPL043W|NOP4|S000005964|Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)
YDR454C	5.53013	PBF1	YDR454C|GUK1|S000002862|Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YER006W	5.51717	PBF1	YER006W|NUG1|S000000808|GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
YLR406C	5.50285	PBF1	YLR406C|RPL31B|S000004398|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YMR113W	5.43351	PBF1	YMR113W|FOL3|S000004719|Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis
YMR112C	5.42661	PBF1	YMR112C|MED11|S000004718|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein
YNL075W	5.42071	PBF1	YNL075W|IMP4|S000005019|Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YIR012W	5.41357	PBF1	YIR012W|SQT1|S000001451|Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay
YBR118W	5.36267	PBF1	YBR118W|TEF2|S000000322|Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YDR447C	5.35558	PBF1	YDR447C|RPS17B|S000002855|Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YLR312W-A	5.35536	PBF1	YLR312W-A|MRPL15|S000004304|Mitochondrial ribosomal protein of the large subunit
YDR384C	5.35172	PBF1	YDR384C|ATO3|S000002792|Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YHR170W	5.34953	PBF1	YHR170W|NMD3|S000001213|Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YKL181W	5.33418	PBF1	YKL181W|PRS1|S000001664|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YDL121C	5.33009	PBF1	YDL121C||S000002279|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YLL034C	5.32839	PBF1	YLL034C|RIX7|S000003957|Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions
YLR435W	5.32433	PBF1	YLR435W|TSR2|S000004427|Protein with a potential role in pre-rRNA processing
YHR181W	5.31738	PBF1	YHR181W|SVP26|S000001224|Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YPR112C	5.31208	PBF1	YPR112C|MRD1|S000006316|Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains
YCR057C	5.31002	PBF1	YCR057C|PWP2|S000000653|Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis
YJL069C	5.29491	PBF1	YJL069C|UTP18|S000003605|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YGR180C	5.28776	PBF1	YGR180C|RNR4|S000003412|Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YIL127C	5.28775	PBF1	YIL127C||S000001389|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YLR349W	5.24951	PBF1	YLR349W||S000004341|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YDL031W	5.22402	PBF1	YDL031W|DBP10|S000002189|Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
YER156C	5.19728	PBF1	YER156C||S000000958|Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR294W	5.19301	PBF1	YOR294W|RRS1|S000005820|Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model mice
YBR104W	5.16765	PBF1	YBR104W|YMC2|S000000308|Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YLR348C	5.06853	PBF1	YLR348C|DIC1|S000004340|Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YJL198W	5.06836	PBF1	YJL198W|PHO90|S000003734|Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YOR287C	5.06469	PBF1	YOR287C||S000005813|Putative protein of unknown function; may play a role in the ribosome and rRNA biosynthesis based on expression profiles and mutant phenotype
YBL031W	5.0437	PBF1	YBL031W|SHE1|S000000127|Cytoskeletal protein of unknown function; overexpression causes growth arrest
YNL065W	5.02605	PBF1	YNL065W|AQR1|S000005009|Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YIL053W	5.02205	PBF1	YIL053W|RHR2|S000001315|Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YOR224C	5.0062	PBF1	YOR224C|RPB8|S000005750|RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III
YIL078W	5.00618	PBF1	YIL078W|THS1|S000001340|Threonyl-tRNA synthetase, essential cytoplasmic protein
YDL229W	4.99935	PBF1	YDL229W|SSB1|S000002388|Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p
YCL064C	4.98033	PBF1	YCL064C|CHA1|S000000569|Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YEL056W	4.9494	PBF1	YEL056W|HAT2|S000000782|Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YJR094W-A	4.93849	PBF1	YJR094W-A|RPL43B|S000003855|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YHR196W	4.9326	PBF1	YHR196W|UTP9|S000001239|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YOL103W	4.88671	PBF1	YOL103W|ITR2|S000005463|Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YGR285C	4.81241	PBF1	YGR285C|ZUO1|S000003517|Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YPR144C	4.78893	PBF1	YPR144C|NOC4|S000006348|Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YKL110C	4.76377	PBF1	YKL110C|KTI12|S000001593|Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YBL069W	4.71207	PBF1	YBL069W|AST1|S000000165|Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts
YLR162W-A	4.706	PBF1	YLR162W-A||S000028567|Putative protein of unknown function identified by fungal homology comparisons and RT-PCR
YBR011C	4.69457	PBF1	YBR011C|IPP1|S000000215|Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YMR246W	4.69069	PBF1	YMR246W|FAA4|S000004860|Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YDL213C	4.67593	PBF1	YDL213C|NOP6|S000002372|Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YPR051W	4.67237	PBF1	YPR051W|MAK3|S000006255|Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
YGR040W	4.66336	PBF1	YGR040W|KSS1|S000003272|Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YOR376W-A	4.63557	PBF1	YOR376W-A||S000028586|Putative protein of unknown function; identified by fungal homology and RT-PCR
YBR069C	4.62662	PBF1	YBR069C|TAT1|S000000273|Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YLR221C	4.59091	PBF1	YLR221C|RSA3|S000004211|Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus
YLR197W	4.58891	PBF1	YLR197W|SIK1|S000004187|Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YCR087C-A	4.58557	PBF1	YCR087C-A|LUG1|S000007223|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YNL132W	4.55756	PBF1	YNL132W|KRE33|S000005076|Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YER131W	4.55205	PBF1	YER131W|RPS26B|S000000933|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YBR034C	4.55164	PBF1	YBR034C|HMT1|S000000238|Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants
YPR137W	4.53885	PBF1	YPR137W|RRP9|S000006341|Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
YOR078W	4.5298	PBF1	YOR078W|BUD21|S000005604|Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern
YPR136C	4.50636	PBF1	YPR136C||S000006340|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
YOL109W	4.49994	PBF1	YOL109W|ZEO1|S000005469|Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
YBL024W	4.47371	PBF1	YBL024W|NCL1|S000000120|S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YPL090C	4.4456	PBF1	YPL090C|RPS6A|S000006011|Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YLR249W	4.42095	PBF1	YLR249W|YEF3|S000004239|Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YOL123W	4.38786	PBF1	YOL123W|HRP1|S000005483|Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YDR161W	4.37257	PBF1	YDR161W||S000002568|Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation
YGL009C	4.36794	PBF1	YGL009C|LEU1|S000002977|Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YCR072C	4.3664	PBF1	YCR072C|RSA4|S000000668|WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
YHR065C	4.36513	PBF1	YHR065C|RRP3|S000001107|Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity
YNL256W	4.35019	PBF1	YNL256W|FOL1|S000005200|Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YLR172C	4.3247	PBF1	YLR172C|DPH5|S000004162|Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm
YGL097W	4.27518	PBF1	YGL097W|SRM1|S000003065|Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YLR301W	4.26832	PBF1	YLR301W||S000004292|Protein of unknown function that interacts with Sec72p
YNL255C	4.2598	PBF1	YNL255C|GIS2|S000005199|Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway
YDL152W	4.25859	PBF1	YDL152W||S000002311|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
YLR222C	4.22544	PBF1	YLR222C|UTP13|S000004212|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YAL036C	4.22372	PBF1	YAL036C|RBG1|S000000034|Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p
YKR099W	4.21626	PBF1	YKR099W|BAS1|S000001807|Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YGR060W	4.21111	PBF1	YGR060W|ERG25|S000003292|C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YER036C	4.17639	PBF1	YER036C|ARB1|S000000838|ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YMR199W	4.16145	PBF1	YMR199W|CLN1|S000004812|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YDR110W	4.14019	PBF1	YDR110W|FOB1|S000002517|Nucleolar protein required for DNA replication fork blocking and recombinational hotspot activities; binds to the replication fork barrier site in the rDNA region; related to retroviral integrases
YCR035C	4.13272	PBF1	YCR035C|RRP43|S000000631|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp4p and Dis3p; required for efficient maturation of 5.8S, 18S and 25S rRNA
YDR346C	4.12302	PBF1	YDR346C|SVF1|S000002754|Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YDR365C	4.09625	PBF1	YDR365C|ESF1|S000002773|Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YGR181W	4.09411	PBF1	YGR181W|TIM13|S000003413|Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YDL241W	4.08756	PBF1	YDL241W||S000002400|Putative protein of unknown function; YDL241W is not an essential gene
YMR116C	4.07087	PBF1	YMR116C|ASC1|S000004722|G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YER168C	4.06405	PBF1	YER168C|CCA1|S000000970|ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites
YLR287C	4.03949	PBF1	YLR287C||S000004277|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene
YPL183C	4.03583	PBF1	YPL183C|RTT10|S000006104|Cytoplasmic protein with a role in regulation of Ty1 transposition
YHR039C-A	4.01981	PBF1	YHR039C-A|VMA10|S000002100|Vacuolar H+ ATPase subunit G of the catalytic (V1) sector, involved in vacuolar acidification
YJL169W	3.98922	PBF1	YJL169W||S000003705|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
YDR184C	3.98621	PBF1	YDR184C|ATC1|S000002592|Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern
YJL109C	3.97253	PBF1	YJL109C|UTP10|S000003645|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YPL141C	3.96337	PBF1	YPL141C||S000006062|Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YKR094C	3.95571	PBF1	YKR094C|RPL40B|S000001802|Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YOR375C	3.93985	PBF1	YOR375C|GDH1|S000005902|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YBR247C	3.92566	PBF1	YBR247C|ENP1|S000000451|Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YOR025W	3.91404	PBF1	YOR025W|HST3|S000005551|Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YOR021C	3.87318	PBF1	YOR021C||S000005547|Putative protein of unknown function; YOR021C is not an essential gene
YML093W	3.86558	PBF1	YML093W|UTP14|S000004558|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YPR110C	3.84984	PBF1	YPR110C|RPC40|S000006314|RNA polymerase subunit, common to RNA polymerase I and III
YLR351C	3.84527	PBF1	YLR351C|NIT3|S000004343|Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YLR154W-C	3.84304	PBF1	YLR154W-C|TAR1|S000028422|Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YER082C	3.84122	PBF1	YER082C|UTP7|S000000884|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YJR105W	3.82287	PBF1	YJR105W|ADO1|S000003866|Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YGL169W	3.81804	PBF1	YGL169W|SUA5|S000003137|Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start
YLR397C	3.78718	PBF1	YLR397C|AFG2|S000004389|ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAs
YJR041C	3.7818	PBF1	YJR041C|URB2|S000003802|Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
YGR138C	3.77736	PBF1	YGR138C|TPO2|S000003370|Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YGR158C	3.77092	PBF1	YGR158C|MTR3|S000003390|3'5' exoribonuclease, exosome subunit; nucleolar protein involved in export of mRNA and ribosomal subunits; homologous to the E. coli exonuclease RNase PH
YPR048W	3.76936	PBF1	YPR048W|TAH18|S000006252|Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta
YJL033W	3.76532	PBF1	YJL033W|HCA4|S000003570|Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
YGL258W	3.75772	PBF1	YGL258W|VEL1|S000003227|Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YFL016C	3.74256	PBF1	YFL016C|MDJ1|S000001878|Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YPL030W	3.72981	PBF1	YPL030W|TRM44|S000005951|tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
YML060W	3.72435	PBF1	YML060W|OGG1|S000004525|Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA
YDR211W	3.71858	PBF1	YDR211W|GCD6|S000002619|Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YCL024W	3.70753	PBF1	YCL024W|KCC4|S000000529|Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YJL011C	3.70087	PBF1	YJL011C|RPC17|S000003548|RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YOR260W	3.68798	PBF1	YOR260W|GCD1|S000005786|Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YDR165W	3.67676	PBF1	YDR165W|TRM82|S000002572|Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YOR359W	3.66673	PBF1	YOR359W|VTS1|S000005886|Post-transcriptional gene regulator, RNA-binding protein containing a SAM domain; shows genetic interactions with Vti1p, which is a v-SNARE involved in cis-Golgi membrane traffic
YGL209W	3.65568	PBF1	YGL209W|MIG2|S000003177|Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YLL064C	3.64478	PBF1	YLL064C|PAU18|S000003987|Hypothetical protein
YBR023C	3.63395	PBF1	YBR023C|CHS3|S000000227|Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YDL201W	3.62392	PBF1	YDL201W|TRM8|S000002360|Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YDR037W	3.61105	PBF1	YDR037W|KRS1|S000002444|Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YMR230W	3.61061	PBF1	YMR230W|RPS10B|S000004843|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
YHR072W-A	3.60998	PBF1	YHR072W-A|NOP10|S000007455|Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA
YOR273C	3.59145	PBF1	YOR273C|TPO4|S000005799|Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YML018C	3.58239	PBF1	YML018C||S000004480|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene
YHR180W-A	3.57282	PBF1	YHR180W-A||S000028555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YML014W	3.56934	PBF1	YML014W|TRM9|S000004476|tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNAs, creating 5-methylcarbonylmethyluridine in tRNA(Arg3) and 5-methylcarbonylmethyl-2-thiouridine in tRNA(Glu); deletion confers resistance to zymocin
YOL125W	3.56161	PBF1	YOL125W|TRM13|S000005485|2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases
YLR268W	3.55681	PBF1	YLR268W|SEC22|S000004258|R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YKL143W	3.52789	PBF1	YKL143W|LTV1|S000001626|Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature
YLR179C	3.50697	PBF1	YLR179C||S000004169|Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YDR261C	3.50513	PBF1	YDR261C|EXG2|S000002669|Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YBR267W	3.50243	PBF1	YBR267W|REI1|S000000471|Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
YLL035W	3.49521	PBF1	YLL035W|GRC3|S000003958|Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated
YLR212C	3.47613	PBF1	YLR212C|TUB4|S000004202|Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YOL085C	3.47334	PBF1	YOL085C||S000005445|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YKL144C	3.46401	PBF1	YKL144C|RPC25|S000001627|RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p
YNL280C	3.43524	PBF1	YNL280C|ERG24|S000005224|C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YBR130C	3.41631	PBF1	YBR130C|SHE3|S000000334|Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
YER183C	3.39142	PBF1	YER183C|FAU1|S000000985|5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YGR121W-A	3.3828	PBF1	YGR121W-A||S000028550|Putative protein of unknown function
YIL131C	3.37932	PBF1	YIL131C|FKH1|S000001393|Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching
YNL251C	3.37444	PBF1	YNL251C|NRD1|S000005195|RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
YPL112C	3.355	PBF1	YPL112C|PEX25|S000006033|Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YMR239C	3.35435	PBF1	YMR239C|RNT1|S000004852|RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end
YML022W	3.35156	PBF1	YML022W|APT1|S000004484|Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YGR140W	3.33263	PBF1	YGR140W|CBF2|S000003372|Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YKR060W	3.30131	PBF1	YKR060W|UTP30|S000001768|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YBR257W	3.28766	PBF1	YBR257W|POP4|S000000461|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
YPR195C	3.27238	PBF1	YPR195C||S000006399|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL022C	3.25319	PBF1	YOL022C|TSR4|S000005382|Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA
YER083C	3.25273	PBF1	YER083C|GET2|S000000885|Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
YDR033W	3.2451	PBF1	YDR033W|MRH1|S000002440|Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YMR093W	3.24105	PBF1	YMR093W|UTP15|S000004699|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YKR038C	3.23359	PBF1	YKR038C|KAE1|S000001746|Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YNL119W	3.19073	PBF1	YNL119W|NCS2|S000005063|Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YBL040C	3.18548	PBF1	YBL040C|ERD2|S000000136|HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
YLR367W	3.16738	PBF1	YLR367W|RPS22B|S000004359|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YDR123C	3.16655	PBF1	YDR123C|INO2|S000002530|Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
YGL099W	3.1471	PBF1	YGL099W|LSG1|S000003067|Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YDR098C	3.13559	PBF1	YDR098C|GRX3|S000002505|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YLR002C	3.13507	PBF1	YLR002C|NOC3|S000003992|Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YOR091W	3.12894	PBF1	YOR091W|TMA46|S000005617|Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p
YJL025W	3.12286	PBF1	YJL025W|RRN7|S000003562|Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn6p and TATA-binding protein
YOR029W	3.12089	PBF1	YOR029W||S000005555|Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGR108W	3.12052	PBF1	YGR108W|CLB1|S000003340|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YHR069C	3.11682	PBF1	YHR069C|RRP4|S000001111|3'-5' exoribonuclease involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3p
YHR172W	3.10715	PBF1	YHR172W|SPC97|S000001215|Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque
YCL023C	3.08712	PBF1	YCL023C||S000000528|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YNL022C	3.08536	PBF1	YNL022C||S000004967|Putative protein of unknown function with seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to a single spot in the nucleus; YNL022C is not an essential gene
YDR280W	3.0782	PBF1	YDR280W|RRP45|S000002688|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YBL044W	3.07818	PBF1	YBL044W||S000000140|Putative protein of unknown function; YBL044W is not an essential protein
YLR183C	3.07714	PBF1	YLR183C|TOS4|S000004173|Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YER133W	3.07337	PBF1	YER133W|GLC7|S000000935|Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
YNL061W	3.05582	PBF1	YNL061W|NOP2|S000005005|Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
YLR063W	3.05392	PBF1	YLR063W||S000004053|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
YPR175W	3.05275	PBF1	YPR175W|DPB2|S000006379|Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
YJL208C	3.04838	PBF1	YJL208C|NUC1|S000003744|Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy
YFR021W	3.03996	PBF1	YFR021W|ATG18|S000001917|Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein
YOR119C	3.02937	PBF1	YOR119C|RIO1|S000005645|Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
YPL081W	3.02662	PBF1	YPL081W|RPS9A|S000006002|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YCR022C	3.0224	PBF1	YCR022C||S000000616|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YLR185W	3.01043	PBF1	YLR185W|RPL37A|S000004175|Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YGR081C	2.98585	PBF1	YGR081C|SLX9|S000003313|Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant
YPL062W	2.98165	PBF1	YPL062W||S000005983|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YER149C	2.97269	PBF1	YER149C|PEA2|S000000951|Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
YML126C	2.97242	PBF1	YML126C|ERG13|S000004595|3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YKL179C	2.97009	PBF1	YKL179C|COY1|S000001662|Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
YGR173W	2.96314	PBF1	YGR173W|RBG2|S000003405|Protein with similarity to mammalian developmentally regulated GTP-binding protein
YER090W	2.96	PBF1	YER090W|TRP2|S000000892|Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YHR070W	2.95535	PBF1	YHR070W|TRM5|S000001112|tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya
YKL125W	2.94338	PBF1	YKL125W|RRN3|S000001608|Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA
YLR195C	2.93799	PBF1	YLR195C|NMT1|S000004185|N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
YER110C	2.92937	PBF1	YER110C|KAP123|S000000912|Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1
YOR225W	2.928	PBF1	YOR225W||S000005751|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPR043W	2.89251	PBF1	YPR043W|RPL43A|S000006247|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YDL047W	2.88549	PBF1	YDL047W|SIT4|S000002205|Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YLR257W	2.88535	PBF1	YLR257W||S000004247|Putative protein of unknown function
YNL301C	2.87651	PBF1	YNL301C|RPL18B|S000005245|Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YKL056C	2.87122	PBF1	YKL056C|TMA19|S000001539|Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
YNL207W	2.86638	PBF1	YNL207W|RIO2|S000005151|Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YDR091C	2.86255	PBF1	YDR091C|RLI1|S000002498|Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YJL125C	2.86105	PBF1	YJL125C|GCD14|S000003661|Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YER091C	2.85546	PBF1	YER091C|MET6|S000000893|Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YIL004C	2.84796	PBF1	YIL004C|BET1|S000001266|Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YJL162C	2.81382	PBF1	YJL162C|JJJ2|S000003698|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YOR185C	2.81145	PBF1	YOR185C|GSP2|S000005711|GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability
YKL120W	2.81104	PBF1	YKL120W|OAC1|S000001603|Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YKL209C	2.806	PBF1	YKL209C|STE6|S000001692|Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YNL253W	2.80596	PBF1	YNL253W|TEX1|S000005197|Protein involved in mRNA export, component of the transcription export (TREX) complex
YJL026C-A	2.75598	PBF1	YJL026C-A||S000028660|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2
YHR088W	2.73946	PBF1	YHR088W|RPF1|S000001130|Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA
YDR278C	2.73805	PBF1	YDR278C||S000002686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR214W	2.73486	PBF1	YGR214W|RPS0A|S000003446|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YPR074W-A	2.73483	PBF1	YPR074W-A||S000007631|Hypothetical protein identified by homology
YPR170W-B	2.72648	PBF1	YPR170W-B||S000028515|Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YHL011C	2.72326	PBF1	YHL011C|PRS3|S000001003|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YOR028C	2.71596	PBF1	YOR028C|CIN5|S000005554|Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YFL026W	2.71142	PBF1	YFL026W|STE2|S000001868|Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YIR013C	2.70617	PBF1	YIR013C|GAT4|S000001452|Protein containing GATA family zinc finger motifs
YCL001W	2.70405	PBF1	YCL001W|RER1|S000000507|Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
YDR534C	2.687	PBF1	YDR534C|FIT1|S000002942|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YCL049C	2.67408	PBF1	YCL049C||S000000554|Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YIL019W	2.66506	PBF1	YIL019W|FAF1|S000001281|Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
YMR259C	2.66143	PBF1	YMR259C||S000004872|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene
YNL120C	2.6401	PBF1	YNL120C||S000005064|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
YNL151C	2.63899	PBF1	YNL151C|RPC31|S000005095|RNA polymerase III subunit C31; contains HMG-like C-terminal domain
YDR449C	2.62466	PBF1	YDR449C|UTP6|S000002857|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YNR008W	2.61576	PBF1	YNR008W|LRO1|S000005291|Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
YBR256C	2.61487	PBF1	YBR256C|RIB5|S000000460|Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YPR014C	2.61312	PBF1	YPR014C||S000006218|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YPL053C	2.59844	PBF1	YPL053C|KTR6|S000005974|Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family
YHR085W	2.5726	PBF1	YHR085W|IPI1|S000001127|Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YLL021W	2.57243	PBF1	YLL021W|SPA2|S000003944|Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YNL001W	2.56092	PBF1	YNL001W|DOM34|S000004946|Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota
YLR074C	2.55608	PBF1	YLR074C|BUD20|S000004064|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YOR274W	2.55541	PBF1	YOR274W|MOD5|S000005800|Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YNL123W	2.54922	PBF1	YNL123W|NMA111|S000005067|Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YML080W	2.53275	PBF1	YML080W|DUS1|S000004545|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17
YNR024W	2.53064	PBF1	YNR024W||S000005307|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YDR041W	2.50391	PBF1	YDR041W|RSM10|S000002448|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YHR081W	2.48478	PBF1	YHR081W|LRP1|S000001123|Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YDR156W	2.48267	PBF1	YDR156W|RPA14|S000002563|RNA polymerase I subunit A14
YDL052C	2.47538	PBF1	YDL052C|SLC1|S000002210|1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
YKR095W-A	2.4718	PBF1	YKR095W-A|PCC1|S000028512|Proposed transcription factor involved in the expression of genes regulated by alpha-factor and galactose; component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; related to human cancer-testis antigens
YGR283C	2.46833	PBF1	YGR283C||S000003515|Protein of unknown function; may interact with ribosomes, based on co-purification experiments; deletion mutant is resistant to fluconazole; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YNL313C	2.46771	PBF1	YNL313C||S000005257|Putative protein of unknown function; identified as interacting with Kar2p, Grs1p, and Tub3p in high-throughput TAP-tagging experiments; YNL313C is an essential gene
YAL053W	2.462	PBF1	YAL053W|FLC2|S000000049|Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YOR095C	2.46168	PBF1	YOR095C|RKI1|S000005621|Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YPL146C	2.45964	PBF1	YPL146C|NOP53|S000006067|Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YJR112W	2.45371	PBF1	YJR112W|NNF1|S000003873|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YMR128W	2.44917	PBF1	YMR128W|ECM16|S000004735|Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis
YLR243W	2.44497	PBF1	YLR243W||S000004233|Putative protein of unknown function; YLR243W is an essential gene
YDR309C	2.44153	PBF1	YDR309C|GIC2|S000002717|Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YBL018C	2.43733	PBF1	YBL018C|POP8|S000000114|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YKR013W	2.43183	PBF1	YKR013W|PRY2|S000001721|Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YER088C-A	2.42332	PBF1	YER088C-A||S000028754|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR058C-A	2.4211	PBF1	YBR058C-A|TSC3|S000007521|Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YOR355W	2.41792	PBF1	YOR355W|GDS1|S000005882|Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR243C	2.41554	PBF1	YBR243C|ALG7|S000000447|UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YJL026W	2.40923	PBF1	YJL026W|RNR2|S000003563|Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YLR449W	2.40034	PBF1	YLR449W|FPR4|S000004441|Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YDR321W	2.38887	PBF1	YDR321W|ASP1|S000002729|Cytosolic L-asparaginase, involved in asparagine catabolism
YLR017W	2.38638	PBF1	YLR017W|MEU1|S000004007|Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
YIR020W-A	2.38225	PBF1	YIR020W-A||S000007241|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YER147C-A	2.38136	PBF1	YER147C-A||S000028759|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL205C	2.36376	PBF1	YDL205C|HEM3|S000002364|Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YOR146W	2.35536	PBF1	YOR146W||S000005672|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YPR080W	2.35036	PBF1	YPR080W|TEF1|S000006284|Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YGR148C	2.34355	PBF1	YGR148C|RPL24B|S000003380|Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YGL245W	2.334	PBF1	YGL245W|GUS1|S000003214|Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm
YGR139W	2.33223	PBF1	YGR139W||S000003371|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL163C	2.31891	PBF1	YNL163C|RIA1|S000005107|Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p)
YBR106W	2.31389	PBF1	YBR106W|PHO88|S000000310|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YCR054C	2.30941	PBF1	YCR054C|CTR86|S000000650|Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis
YLR224W	2.28708	PBF1	YLR224W||S000004214|F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
YBR066C	2.28181	PBF1	YBR066C|NRG2|S000000270|Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YIR019C	2.27821	PBF1	YIR019C|MUC1|S000001458|GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
YNL062C	2.26092	PBF1	YNL062C|GCD10|S000005006|Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YEL055C	2.24107	PBF1	YEL055C|POL5|S000000781|DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
YLR150W	2.24084	PBF1	YLR150W|STM1|S000004140|Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YHR069C-A	2.2279	PBF1	YHR069C-A||S000028779|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL020C	2.21166	PBF1	YIL020C|HIS6|S000001282|Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YDL212W	2.20536	PBF1	YDL212W|SHR3|S000002371|Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YMR269W	2.19427	PBF1	YMR269W|TMA23|S000004882|Nucleolar protein of unknown function implicated in ribosome biogenesis; TMA23 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YKL182W	2.18921	PBF1	YKL182W|FAS1|S000001665|Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YER034W	2.1847	PBF1	YER034W||S000000836|Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
YHR039C	2.17865	PBF1	YHR039C|MSC7|S000001081|Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids
YLR083C	2.17857	PBF1	YLR083C|EMP70|S000004073|Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions
YGR130C	2.17658	PBF1	YGR130C||S000003362|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YKR079C	2.16282	PBF1	YKR079C|TRZ1|S000001787|tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YCR019W	2.15554	PBF1	YCR019W|MAK32|S000000612|Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YDR040C	2.14774	PBF1	YDR040C|ENA1|S000002447|P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YDR496C	2.14685	PBF1	YDR496C|PUF6|S000002904|Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA
YHR041C	2.13683	PBF1	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YLL022C	2.12867	PBF1	YLL022C|HIF1|S000003945|Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing
YAR071W	2.12679	PBF1	YAR071W|PHO11|S000000094|One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YNL209W	2.12623	PBF1	YNL209W|SSB2|S000005153|Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1
YJL124C	2.10037	PBF1	YJL124C|LSM1|S000003660|Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs
YPL217C	2.10004	PBF1	YPL217C|BMS1|S000006138|Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p
YLR336C	2.09828	PBF1	YLR336C|SGD1|S000004328|Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia
YOR001W	2.09803	PBF1	YOR001W|RRP6|S000005527|Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
YML031C-A	2.0923	PBF1	YML031C-A||S000028809|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS
YEL042W	2.08323	PBF1	YEL042W|GDA1|S000000768|Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
YPR170W-A	2.07842	PBF1	YPR170W-A||S000028861|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YOL054W	2.07809	PBF1	YOL054W|PSH1|S000005415|Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein
YGR017W	2.06274	PBF1	YGR017W||S000003249|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YEL026W	2.05168	PBF1	YEL026W|SNU13|S000000752|RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YHR140W	2.05098	PBF1	YHR140W||S000001182|Putative integral membrane protein of unknown function
YOR319W	2.05023	PBF1	YOR319W|HSH49|S000005846|U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YLR146C	2.04448	PBF1	YLR146C|SPE4|S000004136|Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid
YPR190C	2.02377	PBF1	YPR190C|RPC82|S000006394|RNA polymerase III subunit C82
YHL039W	2.02311	PBF1	YHL039W||S000001031|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDL019C	2.02262	PBF1	YDL019C|OSH2|S000002177|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YBL068W-A	2.01847	PBF1	YBL068W-A||S000028530|Dubious open reading frame unlikely to encode a protein; identified by fungal homology and RT-PCR
YOL130W	2.00138	PBF1	YOL130W|ALR1|S000005490|Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YML125C	1.99763	PBF1	YML125C|PGA3|S000004594|Essential protein required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; GFP-fusion protein localizes to the endoplasmic reticulum; null mutants have a cell separation defect
YCR006C	1.99356	PBF1	YCR006C||S000000599|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR240C	1.99036	PBF1	YDR240C|SNU56|S000002648|Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YOR252W	1.98817	PBF1	YOR252W|TMA16|S000005778|Protein of unknown function that associates with ribosomes
YOL136C	1.97983	PBF1	YOL136C|PFK27|S000005496|6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YPL068C	1.96787	PBF1	YPL068C||S000005989|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS
YNL162W-A	1.95506	PBF1	YNL162W-A||S000007624|Putative protein of unknown function, identified by homology
YJR124C	1.95452	PBF1	YJR124C||S000003885|Putative protein of unknown function; expression induced under calcium shortage
YDR531W	1.95253	PBF1	YDR531W||S000002939|Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YGR095C	1.95202	PBF1	YGR095C|RRP46|S000003327|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YKR012C	1.9517	PBF1	YKR012C||S000001720|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YIR020C	1.94663	PBF1	YIR020C||S000001459|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR042W	1.9382	PBF1	YJR042W|NUP85|S000003803|Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking
YEL048C	1.92351	PBF1	YEL048C||S000000774|Putative protein of unknown function; synthetic lethal with gcs1delta
YLR049C	1.91225	PBF1	YLR049C||S000004039|Putative protein of unknown function
YJR145C	1.89243	PBF1	YJR145C|RPS4A|S000003906|Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YBR012C	1.88964	PBF1	YBR012C||S000000216|Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YPL207W	1.88939	PBF1	YPL207W|TYW1|S000006128|Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YOR145C	1.88333	PBF1	YOR145C|PNO1|S000005671|Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain
YGR131W	1.88079	PBF1	YGR131W||S000003363|Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YPR194C	1.87598	PBF1	YPR194C|OPT2|S000006398|Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans
YEL068C	1.8712	PBF1	YEL068C||S000000794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL300W	1.86358	PBF1	YNL300W||S000005244|Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YOL144W	1.85033	PBF1	YOL144W|NOP8|S000005504|Nucleolar protein required for 60S ribosomal subunit biogenesis
YNL084C	1.84244	PBF1	YNL084C|END3|S000005028|EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p
YOR212W	1.84167	PBF1	YOR212W|STE4|S000005738|G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YDR354W	1.8339	PBF1	YDR354W|TRP4|S000002762|Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YAL038W	1.83176	PBF1	YAL038W|CDC19|S000000036|Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YLR293C	1.81779	PBF1	YLR293C|GSP1|S000004284|GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Prp20p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog
YDR344C	1.81249	PBF1	YDR344C||S000002752|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL246C	1.81093	PBF1	YGL246C|RAI1|S000003215|Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processing
YLL036C	1.80976	PBF1	YLL036C|PRP19|S000003959|Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases
YIL119C	1.79532	PBF1	YIL119C|RPI1|S000001381|Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YOR207C	1.78551	PBF1	YOR207C|RET1|S000005733|Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
YDR072C	1.78401	PBF1	YDR072C|IPT1|S000002479|Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YPL118W	1.77446	PBF1	YPL118W|MRP51|S000006039|Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences
YLR067C	1.77373	PBF1	YLR067C|PET309|S000004057|Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; located in the mitochondrial inner membrane
YMR011W	1.76974	PBF1	YMR011W|HXT2|S000004613|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YPR052C	1.76587	PBF1	YPR052C|NHP6A|S000006256|High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to certain promoters
YLR051C	1.75681	PBF1	YLR051C|FCF2|S000004041|Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon
YMR105W-A	1.75021	PBF1	YMR105W-A||S000028692|Putative protein of unknown function
YLR341W	1.74332	PBF1	YLR341W|SPO77|S000004333|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YER127W	1.73105	PBF1	YER127W|LCP5|S000000929|Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
YGL111W	1.7241	PBF1	YGL111W|NSA1|S000003079|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YJL012C	1.72402	PBF1	YJL012C|VTC4|S000003549|Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YFL014W	1.71466	PBF1	YFL014W|HSP12|S000001880|Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YDR509W	1.71292	PBF1	YDR509W||S000002917|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL257C	1.68694	PBF1	YGL257C|MNT2|S000003226|Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
YGL234W	1.67946	PBF1	YGL234W|ADE5,7|S000003203|Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
YGR177C	1.67721	PBF1	YGR177C|ATF2|S000003409|Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YDR508C	1.67561	PBF1	YDR508C|GNP1|S000002916|High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YDR302W	1.67041	PBF1	YDR302W|GPI11|S000002710|ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
YJL105W	1.66997	PBF1	YJL105W|SET4|S000003641|Protein of unknown function, contains a SET domain
YFR051C	1.6588	PBF1	YFR051C|RET2|S000001947|Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YKL191W	1.65786	PBF1	YKL191W|DPH2|S000001674|Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p
YBR227C	1.65748	PBF1	YBR227C|MCX1|S000000431|Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins
YER148W	1.65555	PBF1	YER148W|SPT15|S000000950|TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability
YGL012W	1.65288	PBF1	YGL012W|ERG4|S000002980|C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YOR099W	1.64985	PBF1	YOR099W|KTR1|S000005625|Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YNL229C	1.64781	PBF1	YNL229C|URE2|S000005173|Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
YML031W	1.64022	PBF1	YML031W|NDC1|S000004493|Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II
YDR017C	1.63863	PBF1	YDR017C|KCS1|S000002424|Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance
YML082W	1.62818	PBF1	YML082W||S000004547|Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YPR171W	1.62536	PBF1	YPR171W|BSP1|S000006375|Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YDL100C	1.6185	PBF1	YDL100C|GET3|S000002258|Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking; has low-level ATPase activity and is involved in resistance to heat and metal stress
YCR099C	1.61556	PBF1	YCR099C||S000000696|Putative protein of unknown function
YMR205C	1.6029	PBF1	YMR205C|PFK2|S000004818|Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YJR002W	1.59317	PBF1	YJR002W|MPP10|S000003762|Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p
YKR036C	1.5858	PBF1	YKR036C|CAF4|S000001744|WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission
YBR242W	1.57558	PBF1	YBR242W||S000000446|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YKL128C	1.56851	PBF1	YKL128C|PMU1|S000001611|Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YHL003C	1.56417	PBF1	YHL003C|LAG1|S000000995|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YIL003W	1.54858	PBF1	YIL003W|CFD1|S000001265|Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
YGR162W	1.54535	PBF1	YGR162W|TIF4631|S000003394|Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4632p
YGL034C	1.54386	PBF1	YGL034C||S000003002|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR104C	1.52919	PBF1	YPR104C|FHL1|S000006308|Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4
YDR535C	1.52693	PBF1	YDR535C||S000002943|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YPR149W	1.52555	PBF1	YPR149W|NCE102|S000006353|Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YLR401C	1.51587	PBF1	YLR401C|DUS3|S000004393|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YJL173C	1.50289	PBF1	YJL173C|RFA3|S000003709|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YBR029C	1.49983	PBF1	YBR029C|CDS1|S000000233|Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
YGR146C-A	1.49062	PBF1	YGR146C-A||S000028638|Putative protein of unknown function
YDL167C	1.48829	PBF1	YDL167C|NRP1|S000002326|Protein of unknown function, rich in asparagine residues
YNL299W	1.48398	PBF1	YNL299W|TRF5|S000005243|Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase
YPR058W	1.47755	PBF1	YPR058W|YMC1|S000006262|Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p
YDR345C	1.45864	PBF1	YDR345C|HXT3|S000002753|Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YER130C	1.45454	PBF1	YER130C||S000000932|Hypothetical protein
YHR060W	1.44705	PBF1	YHR060W|VMA22|S000001102|Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YOR030W	1.4372	PBF1	YOR030W|DFG16|S000005556|Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YDR243C	1.43484	PBF1	YDR243C|PRP28|S000002651|RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site
YJR064W	1.43323	PBF1	YJR064W|CCT5|S000003825|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDL048C	1.43024	PBF1	YDL048C|STP4|S000002206|Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YDL030W	1.40933	PBF1	YDL030W|PRP9|S000002188|Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex
YLR003C	1.4057	PBF1	YLR003C||S000003993|Putative protein of unknown function that may participate in DNA replication; green fluorescent protein (GFP)-fusion protein is localized to the nucleus; YLR003C is not an essential gene
YBL004W	1.39072	PBF1	YBL004W|UTP20|S000000100|Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
YOL102C	1.38468	PBF1	YOL102C|TPT1|S000005462|tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide
YER159C	1.38394	PBF1	YER159C|BUR6|S000000961|Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YML015C	1.38255	PBF1	YML015C|TAF11|S000004477|TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YNR015W	1.37696	PBF1	YNR015W|SMM1|S000005298|Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs
YOR354C	1.37456	PBF1	YOR354C|MSC6|S000005881|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YEL066W	1.37165	PBF1	YEL066W|HPA3|S000000792|D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YOR318C	1.36637	PBF1	YOR318C||S000005845|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo
YDR276C	1.36345	PBF1	YDR276C|PMP3|S000002684|Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YPL010W	1.35941	PBF1	YPL010W|RET3|S000005931|Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YJL188C	1.35759	PBF1	YJL188C|BUD19|S000003724|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YPR170C	1.35651	PBF1	YPR170C||S000006374|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YAR008W	1.35504	PBF1	YAR008W|SEN34|S000000066|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YLR011W	1.35256	PBF1	YLR011W|LOT6|S000004001|FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YBL026W	1.35233	PBF1	YBL026W|LSM2|S000000122|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YGL102C	1.34809	PBF1	YGL102C||S000003070|Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YGL028C	1.34106	PBF1	YGL028C|SCW11|S000002996|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YLR028C	1.33088	PBF1	YLR028C|ADE16|S000004018|Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine
YPR146C	1.32744	PBF1	YPR146C||S000006350|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL257C	1.32411	PBF1	YNL257C|SIP3|S000005201|Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate
YGL172W	1.31797	PBF1	YGL172W|NUP49|S000003140|Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes
YKL083W	1.31568	PBF1	YKL083W||S000001566|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
YIL104C	1.3123	PBF1	YIL104C|SHQ1|S000001366|Essential nuclear protein, required for accumulation of box H/ACA snoRNAs and for rRNA processing; interacts with Naf1p
YFL027C	1.29271	PBF1	YFL027C|GYP8|S000001867|GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YBR061C	1.2736	PBF1	YBR061C|TRM7|S000000265|2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
YCR047C	1.27117	PBF1	YCR047C|BUD23|S000000643|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YBR049C	1.2679	PBF1	YBR049C|REB1|S000000253|RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription
YER037W	1.26562	PBF1	YER037W|PHM8|S000000839|Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p
YGR083C	1.26228	PBF1	YGR083C|GCD2|S000003315|Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YML122C	1.23993	PBF1	YML122C||S000004591|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR099W	1.23693	PBF1	YJR099W|YUH1|S000003860|Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YPL041C	1.22949	PBF1	YPL041C||S000005962|Protein of unknown function involved in maintenance of proper telomere length
YDR206W	1.22547	PBF1	YDR206W|EBS1|S000002614|Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
YPR053C	1.21086	PBF1	YPR053C||S000006257|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
YGL035C	1.20234	PBF1	YGL035C|MIG1|S000003003|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YDR020C	1.19869	PBF1	YDR020C|DAS2|S000002427|Predicted protein shares weak similarity with uridine kinases and with phosphoribokinases; null mutant suppresses dst1delta sensitivity for 6-azauracil
YHR162W	1.19689	PBF1	YHR162W||S000001205|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YDR448W	1.18489	PBF1	YDR448W|ADA2|S000002856|Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes
YIL079C	1.18427	PBF1	YIL079C|AIR1|S000001341|RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p
YBR093C	1.17886	PBF1	YBR093C|PHO5|S000000297|Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YLR285C-A	1.17229	PBF1	YLR285C-A||S000028569|Putative protein of unknown function; identified by fungal homology and RT-PCR
YGL016W	1.17028	PBF1	YGL016W|KAP122|S000002984|Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance
YIL169C	1.16027	PBF1	YIL169C||S000001431|Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YMR153W	1.15984	PBF1	YMR153W|NUP53|S000004762|Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex
YPR035W	1.15889	PBF1	YPR035W|GLN1|S000006239|Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
YEL067C	1.1583	PBF1	YEL067C||S000000793|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL003C	1.15514	PBF1	YBL003C|HTA2|S000000099|One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YDR121W	1.15246	PBF1	YDR121W|DPB4|S000002528|Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing
YMR228W	1.14895	PBF1	YMR228W|MTF1|S000004841|Mitochondrial RNA polymerase specificity factor with structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors, interacts with mitochondrial core polymerase Rpo41p
YLR215C	1.14735	PBF1	YLR215C|CDC123|S000004205|Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
YOL092W	1.14688	PBF1	YOL092W||S000005452|Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype
YOL013W-A	1.14528	PBF1	YOL013W-A||S000028811|Putative protein of unknown function; identified by SAGE
YJL072C	1.14322	PBF1	YJL072C|PSF2|S000003608|Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YDR073W	1.12085	PBF1	YDR073W|SNF11|S000002480|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YDR491C	1.12053	PBF1	YDR491C||S000002899|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL137C	1.11989	PBF1	YPL137C|GIP3|S000006058|Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YOR063W	1.1175	PBF1	YOR063W|RPL3|S000005589|Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YDR274C	1.10917	PBF1	YDR274C||S000002682|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR008W	1.10344	PBF1	YCR008W|SAT4|S000000601|Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YNR067C	1.10159	PBF1	YNR067C|DSE4|S000005350|Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YBR030W	1.09764	PBF1	YBR030W||S000000234|Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold)
YKL216W	1.09756	PBF1	YKL216W|URA1|S000001699|Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid
YNL043C	1.09145	PBF1	YNL043C||S000004988|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YCL050C	1.0898	PBF1	YCL050C|APA1|S000000555|Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YOL010W	1.08731	PBF1	YOL010W|RCL1|S000005370|RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity
YOR337W	1.06896	PBF1	YOR337W|TEA1|S000005864|Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein
YMR285C	1.06442	PBF1	YMR285C|NGL2|S000004898|Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p
YDL171C	1.05003	PBF1	YDL171C|GLT1|S000002330|NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source
YJR111C	1.04839	PBF1	YJR111C||S000003872|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
YHR064C	1.04822	PBF1	YHR064C|SSZ1|S000001106|Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
YPL028W	1.04691	PBF1	YPL028W|ERG10|S000005949|Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YOR074C	1.04519	PBF1	YOR074C|CDC21|S000005600|Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YKL127W	1.04179	PBF1	YKL127W|PGM1|S000001610|Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YNR038W	1.04137	PBF1	YNR038W|DBP6|S000005321|Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YOR251C	1.0409	PBF1	YOR251C||S000005777|Putative protein of unknown function with similarity to human thiosulfate sulfurtransferase, an enzyme that catalyzes the transfer of sulfur from thiosulfate to cyanide, forming sulfite and thiocyanate; YOR251C is a non-essential gene
YNR054C	1.04008	PBF1	YNR054C|ESF2|S000005337|Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YER169W	1.03437	PBF1	YER169W|RPH1|S000000971|JmjC domain-containing histone demethylase which can specifically demethylate H3K36 tri- and dimethyl modification states; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway
YNR012W	1.0317	PBF1	YNR012W|URK1|S000005295|Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
YDR341C	1.02523	PBF1	YDR341C||S000002749|Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCR047W-A	1.02401	PBF1	YCR047W-A||S000028608|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YJR133W	1.02001	PBF1	YJR133W|XPT1|S000003894|Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine
YMR121C	1.01788	PBF1	YMR121C|RPL15B|S000004728|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YOR092W	1.01775	PBF1	YOR092W|ECM3|S000005618|Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YDL024C	1.00594	PBF1	YDL024C|DIA3|S000002182|Protein of unknown function, involved in invasive and pseudohyphal growth
YNL231C	0.995283	PBF1	YNL231C|PDR16|S000005175|Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YOR073W-A	0.992376	PBF1	YOR073W-A||S000028583|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR
YHR127W	0.99023	PBF1	YHR127W||S000001169|Protein of unknown function; localizes to the nucleus
YMR296C	0.986423	PBF1	YMR296C|LCB1|S000004911|Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YNL189W	0.985559	PBF1	YNL189W|SRP1|S000005133|Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YNR075W	0.984742	PBF1	YNR075W|COS10|S000005358|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YKL122C	0.979723	PBF1	YKL122C|SRP21|S000001605|Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YIL110W	0.978955	PBF1	YIL110W|MNI1|S000001372|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion mutant exhibits a weak vacuolar protein sorting defect, enhanced resistance to caspofungin, and is synthetically lethal with MEN mutants
YOL014W	0.977806	PBF1	YOL014W||S000005374|Putative protein of unknown function
YGR090W	0.973764	PBF1	YGR090W|UTP22|S000003322|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YCR090C	0.97335	PBF1	YCR090C||S000000686|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
YGR253C	0.972865	PBF1	YGR253C|PUP2|S000003485|Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YOL031C	0.972743	PBF1	YOL031C|SIL1|S000005391|Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YBR009C	0.972088	PBF1	YBR009C|HHF1|S000000213|One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YKL001C	0.970762	PBF1	YKL001C|MET14|S000001484|Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YGL088W	0.962315	PBF1	YGL088W||S000003056|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YER064C	0.961987	PBF1	YER064C||S000000866|Non-essential nuclear protein; null mutation has global effects on transcription
YGR187C	0.960961	PBF1	YGR187C|HGH1|S000003419|Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YMR229C	0.960078	PBF1	YMR229C|RRP5|S000004842|RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome
YLR220W	0.960021	PBF1	YLR220W|CCC1|S000004210|Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation
YGL101W	0.950541	PBF1	YGL101W||S000003069|Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
YBR042C	0.946857	PBF1	YBR042C|CST26|S000000246|Protein of unknown function, affects chromosome stability when overexpressed
YHR136C	0.937556	PBF1	YHR136C|SPL2|S000001178|Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YML005W	0.936758	PBF1	YML005W|TRM12|S000004464|S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YLR163C	0.933193	PBF1	YLR163C|MAS1|S000004153|Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YER016W	0.932577	PBF1	YER016W|BIM1|S000000818|Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YOL061W	0.931713	PBF1	YOL061W|PRS5|S000005422|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YIL130W	0.930623	PBF1	YIL130W|ASG1|S000001392|Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins
YBR125C	0.929641	PBF1	YBR125C|PTC4|S000000329|Cytoplasmic type 2C protein phosphatase; identified as a high-copy number suppressor of the synthetic lethality of a cnb1 mpk1 double deletion; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
YGL067W	0.926021	PBF1	YGL067W|NPY1|S000003035|NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes
YNL312W	0.920458	PBF1	YNL312W|RFA2|S000005256|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YOR233W	0.918607	PBF1	YOR233W|KIN4|S000005759|Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck
YGL158W	0.91709	PBF1	YGL158W|RCK1|S000003126|Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YNR074C	0.916205	PBF1	YNR074C|AIF1|S000005357|Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
YIL051C	0.912938	PBF1	YIL051C|MMF1|S000001313|Mitochondrial protein involved in maintenance of the mitochondrial genome
YDR012W	0.912813	PBF1	YDR012W|RPL4B|S000002419|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
YCL058W-A	0.911482	PBF1	YCL058W-A||S000028518|Protein of unknown function; identified by homology to Ashbya gossypii
YLR254C	0.911395	PBF1	YLR254C|NDL1|S000004244|Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends
YJL179W	0.910817	PBF1	YJL179W|PFD1|S000003715|Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin
YBL002W	0.910734	PBF1	YBL002W|HTB2|S000000098|One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YER011W	0.899437	PBF1	YER011W|TIR1|S000000813|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YNL182C	0.885782	PBF1	YNL182C|IPI3|S000005126|Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YIL021W	0.881428	PBF1	YIL021W|RPB3|S000001283|RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YMR211W	0.878711	PBF1	YMR211W|DML1|S000004824|Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YLR344W	0.861861	PBF1	YLR344W|RPL26A|S000004336|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YLR109W	0.843877	PBF1	YLR109W|AHP1|S000004099|Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YNL066W	0.843335	PBF1	YNL066W|SUN4|S000005010|Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YDL240W	0.821376	PBF1	YDL240W|LRG1|S000002399|Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YOR048C	0.821029	PBF1	YOR048C|RAT1|S000005574|Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination
YGL050W	0.819357	PBF1	YGL050W|TYW3|S000003018|tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YMR108W	0.81865	PBF1	YMR108W|ILV2|S000004714|Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YHR179W	0.815707	PBF1	YHR179W|OYE2|S000001222|Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YIL046W-A	0.813785	PBF1	YIL046W-A||S000028836|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YEL062W	0.806547	PBF1	YEL062W|NPR2|S000000788|Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin
YLR089C	0.805285	PBF1	YLR089C|ALT1|S000004079|Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL014C	0.802409	PBF1	YBL014C|RRN6|S000000110|Protein involved in the transcription of 35S rRNA genes by RNA polymerase I; component of the core factor (CF) complex also composed of Rrn11p, Rrn7p and TATA-binding protein
YDR412W	0.798076	PBF1	YDR412W|RRP17|S000002820|Component of the pre-60S pre-ribosomal particle; required for cell viability
YLR384C	0.791601	PBF1	YLR384C|IKI3|S000004376|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
YKL013C	0.790452	PBF1	YKL013C|ARC19|S000001496|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YCR015C	0.778555	PBF1	YCR015C||S000000608|Putative protein of unknown function; YCR015C is not an essential gene
YER114C	0.768188	PBF1	YER114C|BOI2|S000000916|Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YGR259C	0.765905	PBF1	YGR259C||S000003491|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YER002W	0.765251	PBF1	YER002W|NOP16|S000000804|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YKL082C	0.75991	PBF1	YKL082C|RRP14|S000001565|Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
YPR041W	0.758643	PBF1	YPR041W|TIF5|S000006245|Translation initiation factor eIF-5; N-terminal domain functions as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP; C-terminal domain is the core of ribosomal preinitiation complex formation
YBR084C-A	0.747497	PBF1	YBR084C-A|RPL19A|S000002156|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YIR010W	0.746728	PBF1	YIR010W|DSN1|S000001449|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
YIL159W	0.745299	PBF1	YIL159W|BNR1|S000001421|Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1
YGL092W	0.738873	PBF1	YGL092W|NUP145|S000003060|Essential nucleoporin, catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that is homologous to Nup100p
YGL060W	0.735352	PBF1	YGL060W|YBP2|S000003028|Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p
YGR262C	0.734465	PBF1	YGR262C|BUD32|S000003494|Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p
YLR404W	0.733502	PBF1	YLR404W|FLD1|S000004396|Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy
YML028W	0.732247	PBF1	YML028W|TSA1|S000004490|Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype
YDR303C	0.726083	PBF1	YDR303C|RSC3|S000002711|Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
YNL193W	0.7257	PBF1	YNL193W||S000005137|Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis
YDL242W	0.725177	PBF1	YDL242W||S000002401|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL063C	0.723426	PBF1	YEL063C|CAN1|S000000789|Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
YLL028W	0.721471	PBF1	YLL028W|TPO1|S000003951|Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YGL253W	0.721374	PBF1	YGL253W|HXK2|S000003222|Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YAL019W	0.720413	PBF1	YAL019W|FUN30|S000000017|Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL098W	0.717345	PBF1	YJL098W|SAP185|S000003634|Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
YML071C	0.717115	PBF1	YML071C|COG8|S000004536|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDR492W	0.714763	PBF1	YDR492W|IZH1|S000002900|Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YDR088C	0.710429	PBF1	YDR088C|SLU7|S000002495|RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YFR020W	0.704421	PBF1	YFR020W||S000001916|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR102C	0.700837	PBF1	YJR102C|VPS25|S000003863|Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YKL097C	0.698567	PBF1	YKL097C||S000001580|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YLR412C-A	0.698122	PBF1	YLR412C-A||S000028572|Putative protein of unknown function
YEL025C	0.69491	PBF1	YEL025C||S000000751|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YOR335C	0.694795	PBF1	YOR335C|ALA1|S000005862|Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
YJL006C	0.690301	PBF1	YJL006C|CTK2|S000003543|Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing; has similarity to cyclins
YHR120W	0.690015	PBF1	YHR120W|MSH1|S000001162|DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis
YNL226W	0.680379	PBF1	YNL226W||S000005170|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C
YNR072W	0.6795	PBF1	YNR072W|HXT17|S000005355|Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YEL020C-B	0.675605	PBF1	YEL020C-B||S000028544|Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YMR268C	0.675411	PBF1	YMR268C|PRP24|S000004881|Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
YJL138C	0.675409	PBF1	YJL138C|TIF2|S000003674|Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YPR062W	0.675386	PBF1	YPR062W|FCY1|S000006266|Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YMR288W	0.675274	PBF1	YMR288W|HSH155|S000004901|U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155
YDR155C	0.674854	PBF1	YDR155C|CPR1|S000002562|Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YDR245W	0.673098	PBF1	YDR245W|MNN10|S000002653|Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family
YLR108C	0.671986	PBF1	YLR108C||S000004098|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YJL041W	0.671933	PBF1	YJL041W|NSP1|S000003577|Essential component of the nuclear pore complex, which mediates nuclear import and export
YMR062C	0.671439	PBF1	YMR062C|ECM40|S000004666|Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YPL136W	0.663712	PBF1	YPL136W||S000006057|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C
YOR107W	0.663383	PBF1	YOR107W|RGS2|S000005633|Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YKL047W	0.659514	PBF1	YKL047W||S000001530|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKR031C	0.654582	PBF1	YKR031C|SPO14|S000001739|Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis
YLR306W	0.653799	PBF1	YLR306W|UBC12|S000004297|Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes
YDR152W	0.653675	PBF1	YDR152W|GIR2|S000002559|Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)
YDR371W	0.650016	PBF1	YDR371W|CTS2|S000002779|Sporulation-specific chitinase
YBL068W	0.648828	PBF1	YBL068W|PRS4|S000000164|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YER089C	0.647879	PBF1	YER089C|PTC2|S000000891|Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; role in DNA checkpoint inactivation
YJR076C	0.643968	PBF1	YJR076C|CDC11|S000003837|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YHR005C-A	0.642288	PBF1	YHR005C-A|MRS11|S000003530|Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YOR218C	0.641999	PBF1	YOR218C||S000005744|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W
YDR179W-A	0.641738	PBF1	YDR179W-A||S000002587|Putative protein of unknown function
YHR018C	0.641057	PBF1	YHR018C|ARG4|S000001060|Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
YGL061C	0.6409	PBF1	YGL061C|DUO1|S000003029|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YBR010W	0.64068	PBF1	YBR010W|HHT1|S000000214|One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YGR106C	0.637524	PBF1	YGR106C|VOA1|S000003338|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YMR059W	0.635134	PBF1	YMR059W|SEN15|S000004663|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p
YLR145W	0.629538	PBF1	YLR145W|RMP1|S000004135|Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
YDR370C	0.62441	PBF1	YDR370C||S000002778|Putative protein of unknown function
YFL001W	0.618653	PBF1	YFL001W|DEG1|S000001895|Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm
YIR042C	0.618298	PBF1	YIR042C||S000001481|Putative protein of unknown function; YIR042C is a non-essential gene
YOL021C	0.615295	PBF1	YOL021C|DIS3|S000005381|Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family
YBR187W	0.61489	PBF1	YBR187W|GDT1|S000000391|Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis
YDR076W	0.610355	PBF1	YDR076W|RAD55|S000002483|Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
YBL006C	0.609887	PBF1	YBL006C|LDB7|S000000102|Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YHL013C	0.60736	PBF1	YHL013C|OTU2|S000001005|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
YHR026W	0.606576	PBF1	YHR026W|PPA1|S000001068|Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
YHR049W	0.605146	PBF1	YHR049W|FSH1|S000001091|Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p
YGR179C	0.595204	PBF1	YGR179C|OKP1|S000003411|Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YIR031C	0.594465	PBF1	YIR031C|DAL7|S000001470|Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YBR263W	0.59374	PBF1	YBR263W|SHM1|S000000467|Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine
YLR006C	0.581136	PBF1	YLR006C|SSK1|S000003996|Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
YER118C	0.580796	PBF1	YER118C|SHO1|S000000920|Transmembrane osmosensor, participates in activation of both the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway
YOL142W	0.580662	PBF1	YOL142W|RRP40|S000005502|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YPR173C	0.578497	PBF1	YPR173C|VPS4|S000006377|AAA-type ATPase that is regulated by Vta1p; required for late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism
YJL091C	0.577767	PBF1	YJL091C|GWT1|S000003627|Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YJL008C	0.571954	PBF1	YJL008C|CCT8|S000003545|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YHR098C	0.566007	PBF1	YHR098C|SFB3|S000001140|Member of the Sec24p family; forms a complex, with Sec23p, that is involved in sorting of Pma1p into COPII vesicles; peripheral ER membrane protein; potential Cdc28p substrate
YER092W	0.565456	PBF1	YER092W|IES5|S000000894|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YHL002C-A	0.56545	PBF1	YHL002C-A||S000028770|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR109C	0.562243	PBF1	YDR109C||S000002516|Putative kinase
YDR414C	0.5616	PBF1	YDR414C|ERD1|S000002822|Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
YGL115W	0.561382	PBF1	YGL115W|SNF4|S000003083|Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
YLR442C	0.559139	PBF1	YLR442C|SIR3|S000004434|Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p
YJL222W	0.556233	PBF1	YJL222W|VTH2|S000003758|Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
YAL035W	0.552192	PBF1	YAL035W|FUN12|S000000033|GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2
YOR115C	0.551176	PBF1	YOR115C|TRS33|S000005641|One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YML036W	0.547075	PBF1	YML036W|CGI121|S000004500|Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121
YML094C-A	0.544382	PBF1	YML094C-A||S000004561|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
YJR072C	0.54309	PBF1	YJR072C|NPA3|S000003833|Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex
YGL069C	0.541212	PBF1	YGL069C||S000003037|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance
YLR411W	0.537491	PBF1	YLR411W|CTR3|S000004403|High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YLR319C	0.537288	PBF1	YLR319C|BUD6|S000004311|Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate
YPL011C	0.534192	PBF1	YPL011C|TAF3|S000005932|TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
YJR098C	0.533955	PBF1	YJR098C||S000003859|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR071C-A	0.533099	PBF1	YHR071C-A||S000028781|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W
YEL031W	0.531877	PBF1	YEL031W|SPF1|S000000757|P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1
YGR116W	0.529232	PBF1	YGR116W|SPT6|S000003348|Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
YMR129W	0.526117	PBF1	YMR129W|POM152|S000004736|Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase;
YKL211C	0.524268	PBF1	YKL211C|TRP3|S000001694|Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YGR217W	0.522945	PBF1	YGR217W|CCH1|S000003449|Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
YBR085W	0.51799	PBF1	YBR085W|AAC3|S000000289|Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YDR299W	0.516687	PBF1	YDR299W|BFR2|S000002707|Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A
YNL279W	0.509676	PBF1	YNL279W|PRM1|S000005223|Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
YMR320W	0.506541	PBF1	YMR320W||S000004939|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL126W	0.504447	PBF1	YIL126W|STH1|S000001388|ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YEL036C	0.50424	PBF1	YEL036C|ANP1|S000000762|Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
YGR107W	0.500179	PBF1	YGR107W||S000003339|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL018W	0.499364	PBF1	YCL018W|LEU2|S000000523|Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YDR095C	0.497048	PBF1	YDR095C||S000002502|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR094W	0.49322	PBF1	YDR094W||S000002501|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YHR143W-A	0.491966	PBF1	YHR143W-A|RPC10|S000001185|RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
YDR434W	0.488007	PBF1	YDR434W|GPI17|S000002842|Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
YHL002W	0.485471	PBF1	YHL002W|HSE1|S000000994|Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes
YPR142C	0.477786	PBF1	YPR142C||S000006346|Hypothetical protein; open reading frame overlaps 5' end of essential RRP15 gene required for ribosomal RNA processing
YDR510W	0.469146	PBF1	YDR510W|SMT3|S000002918|Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YBR219C	0.468493	PBF1	YBR219C||S000000423|Putative protein of unknown function; YBR219C is not an essential gene
YKL015W	0.463795	PBF1	YKL015W|PUT3|S000001498|Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binuclear cluster domain
YCR002C	0.455471	PBF1	YCR002C|CDC10|S000000595|Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YJL223C	0.45091	PBF1	YJL223C|PAU1|S000003759|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR349C	0.44964	PBF1	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YJL222W-A	0.443248	PBF1	YJL222W-A||S000028663|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR241W	0.439419	PBF1	YDR241W|BUD26|S000002649|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YAR014C	0.431907	PBF1	YAR014C|BUD14|S000000069|Protein involved in bud-site selection, Bud14p-Glc7p complex functions as a cortical regulator of dynein; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YDR292C	0.430469	PBF1	YDR292C|SRP101|S000002700|Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
YLL031C	0.428624	PBF1	YLL031C|GPI13|S000003954|ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
YML006C	0.427323	PBF1	YML006C|GIS4|S000004465|CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YOR176W	0.425171	PBF1	YOR176W|HEM15|S000005702|Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YER048C	0.42192	PBF1	YER048C|CAJ1|S000000850|Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YBR271W	0.421476	PBF1	YBR271W||S000000475|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene
YLR256W	0.420807	PBF1	YLR256W|HAP1|S000004246|Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus
YDL058W	0.41887	PBF1	YDL058W|USO1|S000002216|Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex
YPR143W	0.411995	PBF1	YPR143W|RRP15|S000006347|Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
YOR056C	0.411347	PBF1	YOR056C|NOB1|S000005582|Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA
YJR104C	0.409201	PBF1	YJR104C|SOD1|S000003865|Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YMR308C	0.40695	PBF1	YMR308C|PSE1|S000004925|Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p
YEL057C	0.405203	PBF1	YEL057C||S000000783|Protein of unknown function involved in telomere maintenance; target of UME6 regulation
YHR187W	0.405171	PBF1	YHR187W|IKI1|S000001230|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin
YHL038C	0.403407	PBF1	YHL038C|CBP2|S000001030|Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
YHR072W	0.402887	PBF1	YHR072W|ERG7|S000001114|Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis
YGR234W	0.400539	PBF1	YGR234W|YHB1|S000003466|Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YBL041W	0.400263	PBF1	YBL041W|PRE7|S000000137|Beta 6 subunit of the 20S proteasome
YPR073C	0.400041	PBF1	YPR073C|LTP1|S000006277|Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine
YDL099W	0.39993	PBF1	YDL099W|BUG1|S000002257|Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YGL113W	0.397607	PBF1	YGL113W|SLD3|S000003081|Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p
YNL221C	0.397212	PBF1	YNL221C|POP1|S000005165|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P
YLR421C	0.39544	PBF1	YLR421C|RPN13|S000004413|Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome
YHR137W	0.392778	PBF1	YHR137W|ARO9|S000001179|Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YOR175C	0.391187	PBF1	YOR175C|ALE1|S000005701|Lysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
YLR056W	0.390369	PBF1	YLR056W|ERG3|S000004046|C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YMR036C	0.389989	PBF1	YMR036C|MIH1|S000004639|Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
YER109C	0.388873	PBF1	YER109C|FLO8|S000000911|Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YDR364C	0.386365	PBF1	YDR364C|CDC40|S000002772|Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats
YML108W	0.386187	PBF1	YML108W||S000004576|Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene
YOL145C	0.381695	PBF1	YOL145C|CTR9|S000005505|Component of the Paf1p complex, which is a large complex that binds to and modulates the activity of RNA polymerase II and is required for expression of a subset of genes, including cyclin genes; contains TPR repeats
YLL048C	0.380726	PBF1	YLL048C|YBT1|S000003971|Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters
YCR098C	0.379871	PBF1	YCR098C|GIT1|S000000695|Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YAL056C-A	0.379768	PBF1	YAL056C-A||S000002139|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL157W	0.374903	PBF1	YPL157W|TGS1|S000006078|Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology
YIL008W	0.370342	PBF1	YIL008W|URM1|S000001270|Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YBR275C	0.36599	PBF1	YBR275C|RIF1|S000000479|Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YPR183W	0.363926	PBF1	YPR183W|DPM1|S000006387|Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation
YDR100W	0.363034	PBF1	YDR100W|TVP15|S000002507|Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p
YLR044C	0.36285	PBF1	YLR044C|PDC1|S000004034|Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism
YMR122W-A	0.360997	PBF1	YMR122W-A||S000007524|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YDR089W	0.35528	PBF1	YDR089W||S000002496|Protein of unknown function; deletion confers resistance to Nickel
YNL108C	0.354155	PBF1	YNL108C||S000005052|Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus
YBR072C-A	0.346045	PBF1	YBR072C-A||S000028532|Putative protein of unknown function; identified by fungal homology and RT-PCR
YMR086C-A	0.343258	PBF1	YMR086C-A||S000004691|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL242C	0.343032	PBF1	YPL242C|IQG1|S000006163|Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family
YER048W-A	0.342255	PBF1	YER048W-A|ISD11|S000007237|Protein required for mitochondrial iron-sulfur cluster biosynthesis
YMR043W	0.339103	PBF1	YMR043W|MCM1|S000004646|Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
YBR073W	0.335662	PBF1	YBR073W|RDH54|S000000277|DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference
YBR176W	0.327852	PBF1	YBR176W|ECM31|S000000380|Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate
YCL010C	0.321131	PBF1	YCL010C|SGF29|S000000516|SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex
YDR300C	0.316834	PBF1	YDR300C|PRO1|S000002708|Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis
YLR090W	0.314361	PBF1	YLR090W|XDJ1|S000004080|Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL014W	0.311799	PBF1	YIL014W|MNT3|S000001276|Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
YFR052W	0.310389	PBF1	YFR052W|RPN12|S000001948|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
YLR039C	0.31023	PBF1	YLR039C|RIC1|S000004029|Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
YHR103W	0.309547	PBF1	YHR103W|SBE22|S000001145|Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
YMR319C	0.304648	PBF1	YMR319C|FET4|S000004938|Low-affinity Fe(II) transporter of the plasma membrane
YJL058C	0.302529	PBF1	YJL058C|BIT61|S000003594|Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity
YMR067C	0.299916	PBF1	YMR067C|UBX4|S000004671|UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YCR003W	0.296977	PBF1	YCR003W|MRPL32|S000000596|Mitochondrial ribosomal protein of the large subunit
YDL125C	0.295661	PBF1	YDL125C|HNT1|S000002283|Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
YHR152W	0.294767	PBF1	YHR152W|SPO12|S000001195|Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
YPL101W	0.293754	PBF1	YPL101W|ELP4|S000006022|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
YBR201W	0.292471	PBF1	YBR201W|DER1|S000000405|Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p
YNL323W	0.29134	PBF1	YNL323W|LEM3|S000005267|Membrane protein of the plasma membrane and ER, involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane
YGR114C	0.289593	PBF1	YGR114C||S000003346|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YGL125W	0.285668	PBF1	YGL125W|MET13|S000003093|Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YOL152W	0.285156	PBF1	YOL152W|FRE7|S000005512|Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YNL218W	0.282311	PBF1	YNL218W|MGS1|S000005162|Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)
YAR007C	0.277627	PBF1	YAR007C|RFA1|S000000065|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YAL044C	0.277023	PBF1	YAL044C|GCV3|S000000042|H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YDR433W	0.276835	PBF1	YDR433W||S000002841|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL201C	0.276101	PBF1	YKL201C|MNN4|S000001684|Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
YDR478W	0.273737	PBF1	YDR478W|SNM1|S000002886|Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YOL020W	0.273526	PBF1	YOL020W|TAT2|S000005380|High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
YER046W	0.272714	PBF1	YER046W|SPO73|S000000848|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis
YLR238W	0.272379	PBF1	YLR238W|FAR10|S000004228|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
YJR141W	0.267988	PBF1	YJR141W||S000003902|Putative protein of unknown function; may be involved in mRNA processing; YJR141W is an essential gene
YAL022C	0.264685	PBF1	YAL022C|FUN26|S000000020|Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes
YBR053C	0.262822	PBF1	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YDL059C	0.260074	PBF1	YDL059C|RAD59|S000002217|Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
YKL012W	0.259233	PBF1	YKL012W|PRP40|S000001495|U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex
YBR024W	0.259164	PBF1	YBR024W|SCO2|S000000228|Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YNL338W	0.25836	PBF1	YNL338W||S000005282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YPL175W	0.258277	PBF1	YPL175W|SPT14|S000006096|UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins
YER045C	0.250417	PBF1	YER045C|ACA1|S000000847|Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources
YPL047W	0.246053	PBF1	YPL047W|SGF11|S000005968|Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation
YDR008C	0.243103	PBF1	YDR008C||S000002415|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR139C	0.242796	PBF1	YJR139C|HOM6|S000003900|Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
YNL239W	0.241644	PBF1	YNL239W|LAP3|S000005183|Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
YLR443W	0.240332	PBF1	YLR443W|ECM7|S000004435|Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency
YKL145W	0.237916	PBF1	YKL145W|RPT1|S000001628|One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p
YNL021W	0.231231	PBF1	YNL021W|HDA1|S000004966|Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation
YLR223C	0.229159	PBF1	YLR223C|IFH1|S000004213|Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate
YBL046W	0.228287	PBF1	YBL046W|PSY4|S000000142|Putative regulatory subunit of an evolutionarily conserved protein phosphatase complex containing the catalytic subunit Pph3p and a third subunit Psy2p; required for cisplatin resistance; GFP-fusion protein localizes to the nucleus
YJL007C	0.225014	PBF1	YJL007C||S000003544|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR244C-A	0.221504	PBF1	YMR244C-A||S000004857|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
YLR305C	0.217351	PBF1	YLR305C|STT4|S000004296|Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
YGR189C	0.214601	PBF1	YGR189C|CRH1|S000003421|Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YIR023W	0.20899	PBF1	YIR023W|DAL81|S000001462|Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YJR094C	0.206253	PBF1	YJR094C|IME1|S000003854|Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YJL216C	0.204762	PBF1	YJL216C||S000003752|Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YOL030W	0.203427	PBF1	YOL030W|GAS5|S000005390|1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YHR076W	0.199737	PBF1	YHR076W|PTC7|S000001118|Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YPR105C	0.198227	PBF1	YPR105C|COG4|S000006309|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YJR055W	0.19752	PBF1	YJR055W|HIT1|S000003816|Protein of unknown function, required for growth at high temperature
YEL046C	0.19297	PBF1	YEL046C|GLY1|S000000772|Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YGL194C-A	0.190652	PBF1	YGL194C-A||S000087160|Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species
YOR052C	0.184506	PBF1	YOR052C||S000005578|Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid
YKR052C	0.182967	PBF1	YKR052C|MRS4|S000001760|Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YPR121W	0.180712	PBF1	YPR121W|THI22|S000006325|Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YML113W	0.176075	PBF1	YML113W|DAT1|S000004581|DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
YBR153W	0.174625	PBF1	YBR153W|RIB7|S000000357|Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
YIL025C	0.173013	PBF1	YIL025C||S000001287|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKR080W	0.172841	PBF1	YKR080W|MTD1|S000001788|NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
YEL045C	0.169951	PBF1	YEL045C||S000000771|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YBR119W	0.169352	PBF1	YBR119W|MUD1|S000000323|U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing
YIR038C	0.167641	PBF1	YIR038C|GTT1|S000001477|ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
YKL048C	0.16522	PBF1	YKL048C|ELM1|S000001531|Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring
YNL191W	0.162763	PBF1	YNL191W|DUG3|S000005135|Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YKL173W	0.160341	PBF1	YKL173W|SNU114|S000001656|GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
YOL059W	0.159101	PBF1	YOL059W|GPD2|S000005420|NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria
YIL030C	0.157384	PBF1	YIL030C|SSM4|S000001292|Ubiquitin-protein ligase of the ER/nuclear envelope, required for degradation of Alpha2p and other proteins containing a Deg1 degradation signal; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
YKL116C	0.154249	PBF1	YKL116C|PRR1|S000001599|Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YGR097W	0.152275	PBF1	YGR097W|ASK10|S000003329|Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YBL104C	0.149456	PBF1	YBL104C||S000000200|Putative protein of unknown function, promoter contains multiple GCN4 binding sites
YJL150W	0.148943	PBF1	YJL150W||S000003686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL254C	0.14391	PBF1	YNL254C|RTC4|S000005198|Hypothetical protein; null mutation suppresses cdc13-1 temperature sensitivity
YFL002C	0.14368	PBF1	YFL002C|SPB4|S000001894|Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YNR051C	0.142549	PBF1	YNR051C|BRE5|S000005334|Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A
YCR081C-A	0.137743	PBF1	YCR081C-A||S000028609|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YKL186C	0.137138	PBF1	YKL186C|MTR2|S000001669|mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA
YJL164C	0.13612	PBF1	YJL164C|TPK1|S000003700|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p
YJL180C	0.135243	PBF1	YJL180C|ATP12|S000003716|Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency
YNL049C	0.134941	PBF1	YNL049C|SFB2|S000004994|Probable component of COPII coated vesicles that binds to Sec23p; similar to and functionally redundant with Sec24p, but expressed at low levels; involved in ER to Golgi transport and in autophagy
YAR015W	0.131892	PBF1	YAR015W|ADE1|S000000070|N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine
YBL108W	0.128175	PBF1	YBL108W||S000000204|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR394C-A	0.12733	PBF1	YOR394C-A||S000028718|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR363C	0.121711	PBF1	YLR363C|NMD4|S000004355|Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway
YPL132W	0.120784	PBF1	YPL132W|COX11|S000006053|Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
YLR266C	0.118375	PBF1	YLR266C|PDR8|S000004256|Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YBR015C	0.11194	PBF1	YBR015C|MNN2|S000000219|Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YCL026C-A	0.110055	PBF1	YCL026C-A|FRM2|S000000589|Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; similar to bacterial nitroreductases
YDR521W	0.108528	PBF1	YDR521W||S000002929|Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
YNR070W	0.108489	PBF1	YNR070W||S000005353|Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR267C	0.107288	PBF1	YOR267C|HRK1|S000005793|Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
YKL101W	0.100958	PBF1	YKL101W|HSL1|S000001584|Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YJR140C	0.0994438	PBF1	YJR140C|HIR3|S000003901|Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly
YOL141W	0.0947634	PBF1	YOL141W|PPM2|S000005501|tRNA methyltransferase required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similar to Ppm1p carboxymethyltransferase
YLR010C	0.0938624	PBF1	YLR010C|TEN1|S000004000|Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YJR116W	0.0930812	PBF1	YJR116W||S000003877|Putative protein of unknown function
YGR178C	0.0920872	PBF1	YGR178C|PBP1|S000003410|Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
YDR150W	0.0916362	PBF1	YDR150W|NUM1|S000002557|Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
YPR145W	0.0851218	PBF1	YPR145W|ASN1|S000006349|Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YCR024C-B	0.082104	PBF1	YCR024C-B||S000028818|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YMR301C	0.0811878	PBF1	YMR301C|ATM1|S000004916|Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
YKL208W	0.0799274	PBF1	YKL208W|CBT1|S000001691|Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
YNL097C	0.0798326	PBF1	YNL097C|PHO23|S000005041|Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)
YBR220C	0.0780516	PBF1	YBR220C||S000000424|Putative protein of unknown function; YBR220C is not an essential gene
YJL215C	0.0734039	PBF1	YJL215C||S000003751|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR122W	0.0701219	PBF1	YDR122W|KIN1|S000002529|Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
YNL068C	0.0677779	PBF1	YNL068C|FKH2|S000005012|Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
YLR414C	0.0637812	PBF1	YLR414C||S000004406|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud and cytoplasm; Hog1p is required for transcriptional induction in response to cell wall damage; YLR414C is not an essential gene
YKL185W	0.0564902	PBF1	YKL185W|ASH1|S000001668|Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate
YJR103W	0.0538974	PBF1	YJR103W|URA8|S000003864|Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YIL029W-A	0.0498976	PBF1	YIL029W-A||S000028788|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL128C	0.0496311	PBF1	YJL128C|PBS2|S000003664|MAP kinase kinase that plays a pivotal role in the osmosensing signal-transduction pathway, activated under severe osmotic stress; plays a role in regulating Ty1 transposition
YNL186W	0.0495689	PBF1	YNL186W|UBP10|S000005130|Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
YML007W	0.0487234	PBF1	YML007W|YAP1|S000004466|Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium
YER188W	0.0474397	PBF1	YER188W||S000000990|Hypothetical protein
YDL185C-A	0.0455998	PBF1	YDL185C-A||S000007600|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species
YFL039C	0.0451939	PBF1	YFL039C|ACT1|S000001855|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YIL095W	0.043785	PBF1	YIL095W|PRK1|S000001357|Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
YER042W	0.0435237	PBF1	YER042W|MXR1|S000000844|Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan
YLR272C	0.0430625	PBF1	YLR272C|YCS4|S000004262|Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin and silencing at the mating type locus
YMR016C	0.0426889	PBF1	YMR016C|SOK2|S000004618|Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YLR007W	0.0423271	PBF1	YLR007W|NSE1|S000003997|Essential subunit of the Mms21-Smc5-Smc6 complex; nuclear protein required for DNA repair and growth; has a nonstructural role in the maintenance of chromosomes
YGR154C	0.0417329	PBF1	YGR154C|GTO1|S000003386|Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
YDL025C	0.0364825	PBF1	YDL025C||S000002183|Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene
YKL068W	0.0328594	PBF1	YKL068W|NUP100|S000001551|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
YBL061C	0.0326629	PBF1	YBL061C|SKT5|S000000157|Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation
YNR005C	0.0322402	PBF1	YNR005C||S000005288|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR376C	0.0300902	PBF1	YLR376C|PSY3|S000004368|Protein of unknown function; deletion results in a mutator phenotype suggesting a role for this protein as a mutational suppressor; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C
YNL107W	0.0272598	PBF1	YNL107W|YAF9|S000005051|Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain
YGR216C	0.0255029	PBF1	YGR216C|GPI1|S000003448|Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
YLR398C	0.0243269	PBF1	YLR398C|SKI2|S000004390|Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA viruses
YHR027C	0.0234302	PBF1	YHR027C|RPN1|S000001069|Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein?protein interactions
YGL098W	0.0194548	PBF1	YGL098W|USE1|S000003066|Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
YIL026C	0.017433	PBF1	YIL026C|IRR1|S000001288|Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YOR196C	0.017317	PBF1	YOR196C|LIP5|S000005722|Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
YLR036C	0.0171772	PBF1	YLR036C||S000004026|Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein
YOR197W	0.0167924	PBF1	YOR197W|MCA1|S000005723|Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment
YNL073W	0.0144373	PBF1	YNL073W|MSK1|S000005017|Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria
YJR132W	0.0141992	PBF1	YJR132W|NMD5|S000003893|Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog
YHR122W	0.0110998	PBF1	YHR122W||S000001164|Protein of unknown function required for establishment of sister chromatid cohesion; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; may be involved in transcription; YHR122W is an essential gene
YDL117W	0.010228	PBF1	YDL117W|CYK3|S000002275|SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis
YHR059W	0.00890621	PBF1	YHR059W|FYV4|S000001101|Protein of unknown function, required for survival upon exposure to K1 killer toxin
YDL185W	0.00802085	PBF1	YDL185W|TFP1|S000002344|Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
YKR039W	0.00716119	PBF1	YKR039W|GAP1|S000001747|General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YCR064C	0.00490492	PBF1	YCR064C||S000000660|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
YNL181W	0.00428305	PBF1	YNL181W||S000005125|Putative oxidoreductase; required for cell viability
YNL048W	0.00381847	PBF1	YNL048W|ALG11|S000004993|Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER
YAR028W	0.00310785	PBF1	YAR028W||S000000076|Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YNR071C	0.00218099	PBF1	YNR071C||S000005354|Putative protein of unknown function
YNL232W	0.000313504	PBF1	YNL232W|CSL4|S000005176|Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation
