YGR157W	10.0669	INO4	YGR157W|CHO2|S000003389|Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis
YDR502C	9.2919	INO4	YDR502C|SAM2|S000002910|S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YKL182W	8.02909	INO4	YKL182W|FAS1|S000001665|Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YDR497C	7.60358	INO4	YDR497C|ITR1|S000002905|Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YIL118W	7.55864	INO4	YIL118W|RHO3|S000001380|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YCR018C	7.33684	INO4	YCR018C|SRD1|S000000611|Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YJL153C	7.27887	INO4	YJL153C|INO1|S000003689|Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YFR055W	7.0157	INO4	YFR055W|IRC7|S000001952|Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C	6.23071	INO4	YFR056C||S000001951|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YNL178W	6.17916	INO4	YNL178W|RPS3|S000005122|Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YJR105W	6.14605	INO4	YJR105W|ADO1|S000003866|Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YAL003W	5.33391	INO4	YAL003W|EFB1|S000000003|Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YKL218C	4.89418	INO4	YKL218C|SRY1|S000001701|3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YEL040W	4.28043	INO4	YEL040W|UTR2|S000000766|Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YPR170W-B	3.87873	INO4	YPR170W-B||S000028515|Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YML026C	3.87021	INO4	YML026C|RPS18B|S000004488|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YBR029C	3.38854	INO4	YBR029C|CDS1|S000000233|Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids
YMR123W	3.1867	INO4	YMR123W|PKR1|S000004730|V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YER043C	3.18056	INO4	YER043C|SAH1|S000000845|S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
YPR170W-A	3.13439	INO4	YPR170W-A||S000028861|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YPL231W	3.12326	INO4	YPL231W|FAS2|S000006152|Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated
YGL077C	3.07965	INO4	YGL077C|HNM1|S000003045|Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol
YPR069C	3.05621	INO4	YPR069C|SPE3|S000006273|Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YPL037C	3.03264	INO4	YPL037C|EGD1|S000005958|Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YGR052W	2.96166	INO4	YGR052W|FMP48|S000003284|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER026C	2.82087	INO4	YER026C|CHO1|S000000828|Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline
YBR210W	2.81397	INO4	YBR210W|ERV15|S000000414|Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YLR154C	2.7399	INO4	YLR154C|RNH203|S000004144|Ribonuclease H2 subunit, required for RNase H2 activity
YDR044W	2.72677	INO4	YDR044W|HEM13|S000002451|Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YHR123W	2.71351	INO4	YHR123W|EPT1|S000001165|sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability
YDR033W	2.68041	INO4	YDR033W|MRH1|S000002440|Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YGR155W	2.62861	INO4	YGR155W|CYS4|S000003387|Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YDR072C	2.54578	INO4	YDR072C|IPT1|S000002479|Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YCR031C	2.45477	INO4	YCR031C|RPS14A|S000000627|Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YKL119C	2.4029	INO4	YKL119C|VPH2|S000001602|Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YMR290C	2.37042	INO4	YMR290C|HAS1|S000004903|ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YLR132C	2.36339	INO4	YLR132C||S000004122|Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YMR290W-A	2.36043	INO4	YMR290W-A||S000004904|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YER117W	2.32888	INO4	YER117W|RPL23B|S000000919|Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YPR010C	2.30443	INO4	YPR010C|RPA135|S000006214|RNA polymerase I subunit A135
YHR208W	2.24629	INO4	YHR208W|BAT1|S000001251|Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YOR108W	2.24431	INO4	YOR108W|LEU9|S000005634|Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YDR344C	2.24408	INO4	YDR344C||S000002752|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR050C	2.24026	INO4	YGR050C||S000003282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL141W	2.2369	INO4	YNL141W|AAH1|S000005085|Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YDR345C	2.23157	INO4	YDR345C|HXT3|S000002753|Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YER102W	2.21209	INO4	YER102W|RPS8B|S000000904|Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YBR030W	2.18843	INO4	YBR030W||S000000234|Putative protein of unknown function; predicted protein contains a SET domain (S-adenosyl-L-methionine-binding fold)
YLR109W	2.18045	INO4	YLR109W|AHP1|S000004099|Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YNR016C	2.17994	INO4	YNR016C|ACC1|S000005299|Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YMR318C	2.17627	INO4	YMR318C|ADH6|S000004937|NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YCR034W	2.09501	INO4	YCR034W|FEN1|S000000630|Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YDR041W	2.09454	INO4	YDR041W|RSM10|S000002448|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YLR154W-B	2.07226	INO4	YLR154W-B||S000028563|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YNL066W	2.06152	INO4	YNL066W|SUN4|S000005010|Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YDR050C	2.02877	INO4	YDR050C|TPI1|S000002457|Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region
YGR159C	2.0253	INO4	YGR159C|NSR1|S000003391|Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YLR154W-A	1.99117	INO4	YLR154W-A||S000028675|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YJR070C	1.96998	INO4	YJR070C|LIA1|S000003831|Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YBR093C	1.95201	INO4	YBR093C|PHO5|S000000297|Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YDR279W	1.94249	INO4	YDR279W|RNH202|S000002687|Ribonuclease H2 subunit, required for RNase H2 activity
YGL120C	1.92995	INO4	YGL120C|PRP43|S000003088|RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YJR071W	1.92934	INO4	YJR071W||S000003832|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR212W	1.92927	INO4	YOR212W|STE4|S000005738|G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YMR246W	1.92417	INO4	YMR246W|FAA4|S000004860|Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YMR011W	1.91917	INO4	YMR011W|HXT2|S000004613|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YNL169C	1.89949	INO4	YNL169C|PSD1|S000005113|Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine
YDR531W	1.89945	INO4	YDR531W||S000002939|Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YOL124C	1.87094	INO4	YOL124C|TRM11|S000005484|Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YLR249W	1.86181	INO4	YLR249W|YEF3|S000004239|Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YLR286C	1.85258	INO4	YLR286C|CTS1|S000004276|Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YKL118W	1.84262	INO4	YKL118W||S000001601|Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YEL053W-A	1.84221	INO4	YEL053W-A||S000028744|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YGR151C	1.81285	INO4	YGR151C||S000003383|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YNL044W	1.79823	INO4	YNL044W|YIP3|S000004989|Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
YNL069C	1.79452	INO4	YNL069C|RPL16B|S000005013|N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YDL226C	1.78166	INO4	YDL226C|GCS1|S000002385|ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YBR158W	1.75329	INO4	YBR158W|AMN1|S000000362|Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YHR032W-A	1.73522	INO4	YHR032W-A||S000028831|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YDR040C	1.71823	INO4	YDR040C|ENA1|S000002447|P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YOL013W-A	1.71712	INO4	YOL013W-A||S000028811|Putative protein of unknown function; identified by SAGE
YGR285C	1.71675	INO4	YGR285C|ZUO1|S000003517|Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YHR143W-A	1.69667	INO4	YHR143W-A|RPC10|S000001185|RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
YNL130C	1.66557	INO4	YNL130C|CPT1|S000005074|Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription
YOL107W	1.6613	INO4	YOL107W||S000005467|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
YBL085W	1.65578	INO4	YBL085W|BOI1|S000000181|Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YHR181W	1.65561	INO4	YHR181W|SVP26|S000001224|Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YJL167W	1.64183	INO4	YJL167W|ERG20|S000003703|Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YGR234W	1.63267	INO4	YGR234W|YHB1|S000003466|Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses
YGR051C	1.62052	INO4	YGR051C||S000003283|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YLR108C	1.6092	INO4	YLR108C||S000004098|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YER019C-A	1.59394	INO4	YER019C-A|SBH2|S000002127|Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YKR038C	1.58922	INO4	YKR038C|KAE1|S000001746|Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YOR272W	1.57502	INO4	YOR272W|YTM1|S000005798|Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YOR029W	1.5494	INO4	YOR029W||S000005555|Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOR234C	1.53329	INO4	YOR234C|RPL33B|S000005760|Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YPR036W	1.52625	INO4	YPR036W|VMA13|S000006240|Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase
YHL020C	1.52319	INO4	YHL020C|OPI1|S000001012|Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
YPR170C	1.50843	INO4	YPR170C||S000006374|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YFR054C	1.5081	INO4	YFR054C||S000001950|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR018W	1.50252	INO4	YNR018W|AIM38|S000005301|Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YLR257W	1.49964	INO4	YLR257W||S000004247|Putative protein of unknown function
YFL015W-A	1.49203	INO4	YFL015W-A||S000028765|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR102C	1.48494	INO4	YJR102C|VPS25|S000003863|Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
YFL015C	1.47226	INO4	YFL015C||S000001879|Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YDR073W	1.46544	INO4	YDR073W|SNF11|S000002480|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YLR011W	1.46115	INO4	YLR011W|LOT6|S000004001|FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YKL068W-A	1.45591	INO4	YKL068W-A||S000028524|Putative protein of unknown function; identified by homology to Ashbya gossypii
YGL148W	1.45161	INO4	YGL148W|ARO2|S000003116|Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YPR171W	1.4422	INO4	YPR171W|BSP1|S000006375|Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YML088W	1.44099	INO4	YML088W|UFO1|S000004553|F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YER137C	1.43531	INO4	YER137C||S000000939|Putative protein of unknown function
YOR108C-A	1.43122	INO4	YOR108C-A||S000028711|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR177C	1.41779	INO4	YGR177C|ATF2|S000003409|Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing
YHR025W	1.41586	INO4	YHR025W|THR1|S000001067|Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
YJL200C	1.38881	INO4	YJL200C|ACO2|S000003736|Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YLR372W	1.38463	INO4	YLR372W|SUR4|S000004364|Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YMR199W	1.36421	INO4	YMR199W|CLN1|S000004812|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YKL117W	1.36133	INO4	YKL117W|SBA1|S000001600|Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YBR023C	1.3595	INO4	YBR023C|CHS3|S000000227|Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YPR033C	1.35829	INO4	YPR033C|HTS1|S000006237|Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YMR194W	1.35822	INO4	YMR194W|RPL36A|S000004807|N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YER009W	1.35728	INO4	YER009W|NTF2|S000000811|Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YOR028C	1.35696	INO4	YOR028C|CIN5|S000005554|Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YHR136C	1.356	INO4	YHR136C|SPL2|S000001178|Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YAR020C	1.34002	INO4	YAR020C|PAU7|S000000073|Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YNL256W	1.33077	INO4	YNL256W|FOL1|S000005200|Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YBR182C-A	1.32916	INO4	YBR182C-A||S000028603|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR004W	1.31736	INO4	YGR004W|PEX31|S000003236|Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
YBR143C	1.30086	INO4	YBR143C|SUP45|S000000347|Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YNL028W	1.2891	INO4	YNL028W||S000004973|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR251W	1.28514	INO4	YGR251W||S000003483|Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YCR019W	1.27537	INO4	YCR019W|MAK32|S000000612|Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YHR067W	1.26592	INO4	YHR067W|HTD2|S000001109|Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
YGR018C	1.25995	INO4	YGR018C||S000003250|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W
YLR206W	1.25883	INO4	YLR206W|ENT2|S000004196|Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YGR280C	1.25659	INO4	YGR280C|PXR1|S000003512|Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YDR146C	1.24653	INO4	YDR146C|SWI5|S000002553|Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YHR018C	1.24305	INO4	YHR018C|ARG4|S000001060|Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway
YHR216W	1.24077	INO4	YHR216W|IMD2|S000001259|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YNL234W	1.23545	INO4	YNL234W||S000005178|Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YLR191W	1.21789	INO4	YLR191W|PEX13|S000004181|Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YPL163C	1.21426	INO4	YPL163C|SVS1|S000006084|Cell wall and vacuolar protein, required for wild-type resistance to vanadate
YGL032C	1.21388	INO4	YGL032C|AGA2|S000003000|Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YPL062W	1.20287	INO4	YPL062W||S000005983|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YHR180W-A	1.2017	INO4	YHR180W-A||S000028555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YER001W	1.19827	INO4	YER001W|MNN1|S000000803|Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YJR123W	1.17949	INO4	YJR123W|RPS5|S000003884|Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YJL048C	1.16346	INO4	YJL048C|UBX6|S000003584|UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline
YML075C	1.16173	INO4	YML075C|HMG1|S000004540|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YER049W	1.15923	INO4	YER049W|TPA1|S000000851|Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YNL029C	1.15864	INO4	YNL029C|KTR5|S000004974|Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YEL001C	1.15147	INO4	YEL001C|IRC22|S000000727|Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YPR157W	1.1496	INO4	YPR157W||S000006361|Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR009W	1.13989	INO4	YMR009W|ADI1|S000004611|Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YOR284W	1.13887	INO4	YOR284W|HUA2|S000005810|Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YIR013C	1.12173	INO4	YIR013C|GAT4|S000001452|Protein containing GATA family zinc finger motifs
YOR376W-A	1.1115	INO4	YOR376W-A||S000028586|Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL023C	1.11137	INO4	YDL023C||S000002181|Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YLR301W	1.1041	INO4	YLR301W||S000004292|Protein of unknown function that interacts with Sec72p
YDL022C-A	1.0965	INO4	YDL022C-A||S000028537|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YJR094W-A	1.09393	INO4	YJR094W-A|RPL43B|S000003855|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YOR247W	1.0876	INO4	YOR247W|SRL1|S000005773|Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YOR271C	1.0807	INO4	YOR271C|FSF1|S000005797|Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YMR321C	1.07828	INO4	YMR321C||S000004940|Putative protein of unknown function
YMR049C	1.06252	INO4	YMR049C|ERB1|S000004652|Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YPL256C	1.04333	INO4	YPL256C|CLN2|S000006177|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YEL056W	1.03452	INO4	YEL056W|HAT2|S000000782|Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YEL034C-A	1.03289	INO4	YEL034C-A||S000028743|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YPR014C	1.03257	INO4	YPR014C||S000006218|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YOR063W	1.02199	INO4	YOR063W|RPL3|S000005589|Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YJL198W	1.02034	INO4	YJL198W|PHO90|S000003734|Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YDL211C	1.01586	INO4	YDL211C||S000002370|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YER107W-A	1.01243	INO4	YER107W-A||S000028755|Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YIL078W	1.00838	INO4	YIL078W|THS1|S000001340|Threonyl-tRNA synthetase, essential cytoplasmic protein
YGR055W	1.00577	INO4	YGR055W|MUP1|S000003287|High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake
YOL103W	0.997997	INO4	YOL103W|ITR2|S000005463|Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YER091C	0.995863	INO4	YER091C|MET6|S000000893|Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YLR416C	0.990565	INO4	YLR416C||S000004408|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR321W	0.990244	INO4	YDR321W|ASP1|S000002729|Cytosolic L-asparaginase, involved in asparagine catabolism
YOL123W	0.985296	INO4	YOL123W|HRP1|S000005483|Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YJL188C	0.983612	INO4	YJL188C|BUD19|S000003724|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YNR072W	0.961637	INO4	YNR072W|HXT17|S000005355|Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YDR212W	0.956979	INO4	YDR212W|TCP1|S000002620|Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide
YBR171W	0.949078	INO4	YBR171W|SEC66|S000000375|Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YCL059C	0.945174	INO4	YCL059C|KRR1|S000000564|Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit
YBR106W	0.943321	INO4	YBR106W|PHO88|S000000310|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YML103C	0.939673	INO4	YML103C|NUP188|S000004571|Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YJL168C	0.938035	INO4	YJL168C|SET2|S000003704|Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YIL119C	0.937925	INO4	YIL119C|RPI1|S000001381|Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YDR211W	0.934274	INO4	YDR211W|GCD6|S000002619|Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YER107C	0.928124	INO4	YER107C|GLE2|S000000909|Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YOL127W	0.922516	INO4	YOL127W|RPL25|S000005487|Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YOR273C	0.913279	INO4	YOR273C|TPO4|S000005799|Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YDR324C	0.910222	INO4	YDR324C|UTP4|S000002732|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGR017W	0.910189	INO4	YGR017W||S000003249|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YFR025C	0.907441	INO4	YFR025C|HIS2|S000001921|Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YDL022W	0.907067	INO4	YDL022W|GPD1|S000002180|NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YLR180W	0.906544	INO4	YLR180W|SAM1|S000004170|S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YPL131W	0.898599	INO4	YPL131W|RPL5|S000006052|Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YJL091C	0.889236	INO4	YJL091C|GWT1|S000003627|Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YBL029W	0.872018	INO4	YBL029W||S000000125|Non-essential protein of unknown function
YBL072C	0.867479	INO4	YBL072C|RPS8A|S000000168|Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
YDL225W	0.862239	INO4	YDL225W|SHS1|S000002384|One of five related septins (Cdc3p, Cdc10p, Cdc11p, Cdc12p, Shs1p) that form a cortical filamentous collar at the mother-bud neck which is necessary for normal morphogenesis and cytokinesis
YGL097W	0.862139	INO4	YGL097W|SRM1|S000003065|Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YLR154W-C	0.861578	INO4	YLR154W-C|TAR1|S000028422|Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YKR074W	0.859239	INO4	YKR074W|AIM29|S000001782|Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDL189W	0.852083	INO4	YDL189W|RBS1|S000002348|Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
YOR375C	0.851797	INO4	YOR375C|GDH1|S000005902|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YPL091W	0.841414	INO4	YPL091W|GLR1|S000006012|Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione
YHR170W	0.839508	INO4	YHR170W|NMD3|S000001213|Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YPR126C	0.824176	INO4	YPR126C||S000006330|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL096W-A	0.816301	INO4	YKL096W-A|CWP2|S000001956|Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YCR102W-A	0.814839	INO4	YCR102W-A||S000007231|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL053C	0.79713	INO4	YPL053C|KTR6|S000005974|Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family
YDR184C	0.795407	INO4	YDR184C|ATC1|S000002592|Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern
YER177W	0.794263	INO4	YER177W|BMH1|S000000979|14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YLR367W	0.786702	INO4	YLR367W|RPS22B|S000004359|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YBR087W	0.78532	INO4	YBR087W|RFC5|S000000291|Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YNL138W	0.784411	INO4	YNL138W|SRV2|S000005082|CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis
YJL222W	0.783862	INO4	YJL222W|VTH2|S000003758|Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
YBR181C	0.783403	INO4	YBR181C|RPS6B|S000000385|Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YLR133W	0.782927	INO4	YLR133W|CKI1|S000004123|Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway
YGR293C	0.781131	INO4	YGR293C||S000003525|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YLR017W	0.781114	INO4	YLR017W|MEU1|S000004007|Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression
YER056C-A	0.781085	INO4	YER056C-A|RPL34A|S000002135|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YKL212W	0.778362	INO4	YKL212W|SAC1|S000001695|Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism
YPR167C	0.776507	INO4	YPR167C|MET16|S000006371|3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
YNL111C	0.767133	INO4	YNL111C|CYB5|S000005055|Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YBR232C	0.765661	INO4	YBR232C||S000000436|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL219W	0.75978	INO4	YKL219W|COS9|S000001702|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YMR029C	0.746676	INO4	YMR029C|FAR8|S000004631|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
YGR218W	0.746241	INO4	YGR218W|CRM1|S000003450|Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
YDR278C	0.744344	INO4	YDR278C||S000002686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER007C-A	0.744222	INO4	YER007C-A|TMA20|S000002957|Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1
YKR041W	0.74377	INO4	YKR041W||S000001749|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YJL222W-A	0.739619	INO4	YJL222W-A||S000028663|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR163C	0.738298	INO4	YPR163C|TIF3|S000006367|Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YLR417W	0.738056	INO4	YLR417W|VPS36|S000004409|Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
YLR190W	0.730681	INO4	YLR190W|MMR1|S000004180|Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p
YKL153W	0.728611	INO4	YKL153W||S000001636|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YKR056W	0.727339	INO4	YKR056W|TRM2|S000001764|tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair
YLR162W-A	0.726263	INO4	YLR162W-A||S000028567|Putative protein of unknown function identified by fungal homology comparisons and RT-PCR
YDR381W	0.721708	INO4	YDR381W|YRA1|S000002789|Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YBR233W	0.721254	INO4	YBR233W|PBP2|S000000437|RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length
YKL056C	0.720847	INO4	YKL056C|TMA19|S000001539|Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress
YOR317W	0.718507	INO4	YOR317W|FAA1|S000005844|Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase
YDR539W	0.715263	INO4	YDR539W||S000002947|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR539W is not an essential gene; homolog of E. coli UbiD
YBR300C	0.698552	INO4	YBR300C||S000000504|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YMR178W	0.695339	INO4	YMR178W||S000004790|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene
YER124C	0.68796	INO4	YER124C|DSE1|S000000926|Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YHR083W	0.686842	INO4	YHR083W|SAM35|S000001125|Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YDR147W	0.683272	INO4	YDR147W|EKI1|S000002554|Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway
YHR133C	0.681956	INO4	YHR133C|NSG1|S000001175|Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins
YDR201W	0.68142	INO4	YDR201W|SPC19|S000002609|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YMR320W	0.681223	INO4	YMR320W||S000004939|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR177C	0.680804	INO4	YBR177C|EHT1|S000000381|Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YNL235C	0.676994	INO4	YNL235C||S000005179|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
YER055C	0.676298	INO4	YER055C|HIS1|S000000857|ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YJR104C	0.671887	INO4	YJR104C|SOD1|S000003865|Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YMR012W	0.669815	INO4	YMR012W|CLU1|S000004614|eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YNR017W	0.669608	INO4	YNR017W|TIM23|S000005300|Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
YPL177C	0.667813	INO4	YPL177C|CUP9|S000006098|Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YJL223C	0.666937	INO4	YJL223C|PAU1|S000003759|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YHR094C	0.664081	INO4	YHR094C|HXT1|S000001136|Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YNL027W	0.661889	INO4	YNL027W|CRZ1|S000004972|Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation
YMR281W	0.655261	INO4	YMR281W|GPI12|S000004894|ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YPL075W	0.644027	INO4	YPL075W|GCR1|S000005996|Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YDR417C	0.643255	INO4	YDR417C||S000002825|Hypothetical protein
YGR148C	0.640185	INO4	YGR148C|RPL24B|S000003380|Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YFL016C	0.632054	INO4	YFL016C|MDJ1|S000001878|Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YJL158C	0.631272	INO4	YJL158C|CIS3|S000003694|Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YKL164C	0.630117	INO4	YKL164C|PIR1|S000001647|O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YHR013C	0.626246	INO4	YHR013C|ARD1|S000001055|Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YAL026C	0.625113	INO4	YAL026C|DRS2|S000000024|Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vessicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
YML046W	0.623716	INO4	YML046W|PRP39|S000004509|U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
YJL148W	0.622438	INO4	YJL148W|RPA34|S000003684|RNA polymerase I subunit A34.5
YJL193W	0.622386	INO4	YJL193W||S000003729|Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
YGL076C	0.621459	INO4	YGL076C|RPL7A|S000003044|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YOR043W	0.621443	INO4	YOR043W|WHI2|S000005569|Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YER048W-A	0.619518	INO4	YER048W-A|ISD11|S000007237|Protein required for mitochondrial iron-sulfur cluster biosynthesis
YGR156W	0.618758	INO4	YGR156W|PTI1|S000003388|Pta1p Interacting protein
YJR114W	0.617155	INO4	YJR114W||S000003875|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YMR307W	0.61499	INO4	YMR307W|GAS1|S000004924|Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YOR226C	0.613993	INO4	YOR226C|ISU2|S000005752|Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YDR099W	0.611241	INO4	YDR099W|BMH2|S000002506|14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YNL320W	0.610244	INO4	YNL320W||S000005264|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR048W	0.610243	INO4	YBR048W|RPS11B|S000000252|Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YKL128C	0.609448	INO4	YKL128C|PMU1|S000001611|Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YDR045C	0.607721	INO4	YDR045C|RPC11|S000002452|RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YHR064C	0.607572	INO4	YHR064C|SSZ1|S000001106|Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
YCR099C	0.603263	INO4	YCR099C||S000000696|Putative protein of unknown function
YJL157C	0.598807	INO4	YJL157C|FAR1|S000003693|Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YHR137W	0.59624	INO4	YHR137W|ARO9|S000001179|Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YBR066C	0.591997	INO4	YBR066C|NRG2|S000000270|Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YPL146C	0.574033	INO4	YPL146C|NOP53|S000006067|Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
YAL038W	0.572418	INO4	YAL038W|CDC19|S000000036|Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YOR030W	0.57184	INO4	YOR030W|DFG16|S000005556|Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YNL182C	0.566354	INO4	YNL182C|IPI3|S000005126|Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YOR101W	0.562619	INO4	YOR101W|RAS1|S000005627|GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YAL025C	0.562364	INO4	YAL025C|MAK16|S000000023|Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YJR113C	0.561799	INO4	YJR113C|RSM7|S000003874|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YFR009W	0.560324	INO4	YFR009W|GCN20|S000001905|Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YDR037W	0.556176	INO4	YDR037W|KRS1|S000002444|Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YGL158W	0.554508	INO4	YGL158W|RCK1|S000003126|Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YOR001W	0.552893	INO4	YOR001W|RRP6|S000005527|Exonuclease component of the nuclear exosome; contributes to the quality-control system that retains and degrades aberrant mRNAs in the nucleus
YER011W	0.552593	INO4	YER011W|TIR1|S000000813|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YER048C	0.54569	INO4	YER048C|CAJ1|S000000850|Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YBR126W-A	0.543411	INO4	YBR126W-A||S000028600|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YOR315W	0.543131	INO4	YOR315W|SFG1|S000005842|Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YMR006C	0.543009	INO4	YMR006C|PLB2|S000004608|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YML111W	0.541754	INO4	YML111W|BUL2|S000004579|Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1
YHL011C	0.541503	INO4	YHL011C|PRS3|S000001003|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YBR011C	0.537756	INO4	YBR011C|IPP1|S000000215|Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YMR194C-A	0.53347	INO4	YMR194C-A||S000007250|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR006C	0.531031	INO4	YCR006C||S000000599|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL189W	0.527223	INO4	YNL189W|SRP1|S000005133|Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YJR057W	0.525609	INO4	YJR057W|CDC8|S000003818|Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YCR102C	0.523802	INO4	YCR102C||S000000699|Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YER021W	0.523199	INO4	YER021W|RPN3|S000000823|Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
YDR008C	0.51826	INO4	YDR008C||S000002415|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL253C	0.517989	INO4	YPL253C|VIK1|S000006174|Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p
YOR230W	0.515768	INO4	YOR230W|WTM1|S000005756|Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
YMR149W	0.513933	INO4	YMR149W|SWP1|S000004757|Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum
YOR276W	0.511951	INO4	YOR276W|CAF20|S000005802|Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
YNL035C	0.506448	INO4	YNL035C||S000004980|Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YMR319C	0.505995	INO4	YMR319C|FET4|S000004938|Low-affinity Fe(II) transporter of the plasma membrane
YOL101C	0.505867	INO4	YOL101C|IZH4|S000005461|Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YEL068C	0.504422	INO4	YEL068C||S000000794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR344W	0.496742	INO4	YLR344W|RPL26A|S000004336|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YNL257C	0.496597	INO4	YNL257C|SIP3|S000005201|Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate
YLR448W	0.494881	INO4	YLR448W|RPL6B|S000004440|Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YKL091C	0.492156	INO4	YKL091C||S000001574|Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YDL148C	0.483811	INO4	YDL148C|NOP14|S000002307|Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
YCR087C-A	0.483395	INO4	YCR087C-A|LUG1|S000007223|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YDR156W	0.48148	INO4	YDR156W|RPA14|S000002563|RNA polymerase I subunit A14
YNL043C	0.48075	INO4	YNL043C||S000004988|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YDR133C	0.479644	INO4	YDR133C||S000002540|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YCR104W	0.47622	INO4	YCR104W|PAU3|S000000701|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YLR042C	0.474361	INO4	YLR042C||S000004032|Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YHL034C	0.47353	INO4	YHL034C|SBP1|S000001026|Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
YKL110C	0.468157	INO4	YKL110C|KTI12|S000001593|Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YPL142C	0.467917	INO4	YPL142C||S000006063|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YDR454C	0.465114	INO4	YDR454C|GUK1|S000002862|Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YDR091C	0.462649	INO4	YDR091C|RLI1|S000002498|Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YPL160W	0.462401	INO4	YPL160W|CDC60|S000006081|Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
YOR176W	0.462304	INO4	YOR176W|HEM15|S000005702|Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YNL265C	0.461312	INO4	YNL265C|IST1|S000005209|Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p
YOR164C	0.461237	INO4	YOR164C||S000005690|Protein of unknown function; highly conserved across species and homologous to human gene C7orf20; interacts with Mdy2p
YOR153W	0.460155	INO4	YOR153W|PDR5|S000005679|Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YBR104W	0.458109	INO4	YBR104W|YMC2|S000000308|Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p
YGL115W	0.457399	INO4	YGL115W|SNF4|S000003083|Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis
YDL167C	0.454169	INO4	YDL167C|NRP1|S000002326|Protein of unknown function, rich in asparagine residues
YEL055C	0.452336	INO4	YEL055C|POL5|S000000781|DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
YGL135W	0.448537	INO4	YGL135W|RPL1B|S000003103|N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YHR174W	0.448422	INO4	YHR174W|ENO2|S000001217|Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YER031C	0.447225	INO4	YER031C|YPT31|S000000833|GTPase of the Ypt/Rab family, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi
YHR041C	0.439698	INO4	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YER073W	0.438991	INO4	YER073W|ALD5|S000000875|Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YDR407C	0.436325	INO4	YDR407C|TRS120|S000002815|One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YPL157W	0.435797	INO4	YPL157W|TGS1|S000006078|Trimethyl guanosine synthase, conserved nucleolar methyl transferase responsible for conversion of the m(7)G cap structure of snRNAs and snoRNAs to m(2,2,7)G; also required for ribosome synthesis and nucleolar morphology
YML102W	0.435767	INO4	YML102W|CAC2|S000004570|Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
YDL003W	0.434982	INO4	YDL003W|MCD1|S000002161|Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YNR001W-A	0.434847	INO4	YNR001W-A||S000007625|Dubious open reading frame unlikely to encode a functional protein; identified by homology
YKL090W	0.434082	INO4	YKL090W|CUE2|S000001573|Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YLR168C	0.433696	INO4	YLR168C|AIM30|S000004158|Putative protein of unknown function that may be involved in intramitochondrial sorting; similar to Ups1p and to human PRELI; GFP-tagged protein localizes to mitochondria; required for wild-type respiratory growth
YNL307C	0.433666	INO4	YNL307C|MCK1|S000005251|Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family
YCR024C-B	0.433234	INO4	YCR024C-B||S000028818|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YML085C	0.43322	INO4	YML085C|TUB1|S000004550|Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
YPR029C	0.432903	INO4	YPR029C|APL4|S000006233|Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YPR034W	0.432605	INO4	YPR034W|ARP7|S000006238|Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YLR179C	0.429928	INO4	YLR179C||S000004169|Protein of unknown function, transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus; YLR179C is not essential
YKL127W	0.427388	INO4	YKL127W|PGM1|S000001610|Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YER063W	0.4171	INO4	YER063W|THO1|S000000865|Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
YOR316C-A	0.414528	INO4	YOR316C-A||S000028584|Putative protein of unknown function; identified by fungal homology and RT-PCR
YOR274W	0.412764	INO4	YOR274W|MOD5|S000005800|Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YLR253W	0.409038	INO4	YLR253W||S000004243|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene
YOR206W	0.407494	INO4	YOR206W|NOC2|S000005732|Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YLR110C	0.406977	INO4	YLR110C|CCW12|S000004100|Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YBL108W	0.406509	INO4	YBL108W||S000000204|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL125W	0.405398	INO4	YKL125W|RRN3|S000001608|Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA
YEL048C	0.40446	INO4	YEL048C||S000000774|Putative protein of unknown function; synthetic lethal with gcs1delta
YDR023W	0.401324	INO4	YDR023W|SES1|S000002430|Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YEL066W	0.401147	INO4	YEL066W|HPA3|S000000792|D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YMR083W	0.40071	INO4	YMR083W|ADH3|S000004688|Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YPL178W	0.399682	INO4	YPL178W|CBC2|S000006099|Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YOR011W	0.39881	INO4	YOR011W|AUS1|S000005537|Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YGR040W	0.398236	INO4	YGR040W|KSS1|S000003272|Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YOR008C-A	0.396823	INO4	YOR008C-A||S000006431|Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YNR054C	0.393597	INO4	YNR054C|ESF2|S000005337|Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YOR175C	0.392617	INO4	YOR175C|ALE1|S000005701|Lysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
YMR024W	0.390398	INO4	YMR024W|MRPL3|S000004626|Mitochondrial ribosomal protein of the large subunit
YMR037C	0.387179	INO4	YMR037C|MSN2|S000004640|Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YJL115W	0.386464	INO4	YJL115W|ASF1|S000003651|Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YBR126C	0.377359	INO4	YBR126C|TPS1|S000000330|Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YOR277C	0.37679	INO4	YOR277C||S000005803|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YDL080C	0.376023	INO4	YDL080C|THI3|S000002238|Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis
YAR018C	0.374997	INO4	YAR018C|KIN3|S000000071|Nonessential protein kinase with unknown cellular role
YFL056C	0.37349	INO4	YFL056C|AAD6|S000001838|Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YOR047C	0.372151	INO4	YOR047C|STD1|S000005573|Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YJL140W	0.371173	INO4	YJL140W|RPB4|S000003676|RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions
YDL240W	0.37082	INO4	YDL240W|LRG1|S000002399|Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YAR002W	0.370649	INO4	YAR002W|NUP60|S000000063|Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YOL008W	0.370383	INO4	YOL008W|COQ10|S000005368|Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes
YDR382W	0.370373	INO4	YDR382W|RPP2B|S000002790|Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YGL028C	0.368928	INO4	YGL028C|SCW11|S000002996|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YGR294W	0.367843	INO4	YGR294W|PAU12|S000003526|Hypothetical protein
YKL122C	0.365466	INO4	YKL122C|SRP21|S000001605|Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YPR132W	0.356943	INO4	YPR132W|RPS23B|S000006336|Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal
YMR183C	0.356742	INO4	YMR183C|SSO2|S000004795|Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YNL016W	0.355904	INO4	YNL016W|PUB1|S000004961|Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YDL055C	0.354094	INO4	YDL055C|PSA1|S000002213|GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YJL147C	0.353133	INO4	YJL147C||S000003683|Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene
YAL007C	0.352347	INO4	YAL007C|ERP2|S000000005|Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YPR079W	0.350428	INO4	YPR079W|MRL1|S000006283|Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases
YMR230W	0.348624	INO4	YMR230W|RPS10B|S000004843|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
YJR103W	0.346534	INO4	YJR103W|URA8|S000003864|Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YBR088C	0.346518	INO4	YBR088C|POL30|S000000292|Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YNL065W	0.345762	INO4	YNL065W|AQR1|S000005009|Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YGR138C	0.343126	INO4	YGR138C|TPO2|S000003370|Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YDR209C	0.342861	INO4	YDR209C||S000002617|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
YKL213C	0.337716	INO4	YKL213C|DOA1|S000001696|WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase
YEL026W	0.336488	INO4	YEL026W|SNU13|S000000752|RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YDL125C	0.329686	INO4	YDL125C|HNT1|S000002283|Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint
YIL074C	0.32709	INO4	YIL074C|SER33|S000001336|3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YDR432W	0.326326	INO4	YDR432W|NPL3|S000002840|RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; dissociation from mRNAs is promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm
YPR058W	0.326121	INO4	YPR058W|YMC1|S000006262|Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p
YEL067C	0.323811	INO4	YEL067C||S000000793|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR003W	0.319147	INO4	YMR003W|AIM34|S000004605|Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YGR090W	0.317185	INO4	YGR090W|UTP22|S000003322|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YLR420W	0.317054	INO4	YLR420W|URA4|S000004412|Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YDR238C	0.313495	INO4	YDR238C|SEC26|S000002646|Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YCL001W	0.313476	INO4	YCL001W|RER1|S000000507|Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER
YDL047W	0.313184	INO4	YDL047W|SIT4|S000002205|Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YJL012C	0.311809	INO4	YJL012C|VTC4|S000003549|Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YEL032W	0.307879	INO4	YEL032W|MCM3|S000000758|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGR217W	0.305675	INO4	YGR217W|CCH1|S000003449|Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
YOL012C	0.305126	INO4	YOL012C|HTZ1|S000005372|Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YDR408C	0.302929	INO4	YDR408C|ADE8|S000002816|Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
YLR171W	0.301843	INO4	YLR171W||S000004161|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL104W	0.301695	INO4	YJL104W|PAM16|S000003640|Constituent of the mitochondrial import motor associated with the presequence translocase, along with Ssc1p, Tim44p, Mge1p, and Pam18p; forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains J-like domain
YHR076W	0.301227	INO4	YHR076W|PTC7|S000001118|Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YCL007C	0.300558	INO4	YCL007C||S000000513|Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A
YMR146C	0.296968	INO4	YMR146C|TIF34|S000004754|Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation
YDR274C	0.296954	INO4	YDR274C||S000002682|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR310C	0.296365	INO4	YOR310C|NOP58|S000005837|Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA
YNL315C	0.296035	INO4	YNL315C|ATP11|S000005259|Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase
YER022W	0.293317	INO4	YER022W|SRB4|S000000824|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YDR297W	0.293312	INO4	YDR297W|SUR2|S000002705|Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YER036C	0.292815	INO4	YER036C|ARB1|S000000838|ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YGR131W	0.29237	INO4	YGR131W||S000003363|Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YDR165W	0.290483	INO4	YDR165W|TRM82|S000002572|Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YFR018C	0.289549	INO4	YFR018C||S000001914|Putative protein of unknown function
YER052C	0.288057	INO4	YER052C|HOM3|S000000854|Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YER112W	0.287568	INO4	YER112W|LSM4|S000000914|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YIL138C	0.285095	INO4	YIL138C|TPM2|S000001400|Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p
YER145C-A	0.283339	INO4	YER145C-A||S000028758|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF LSM5/YER146W
YOL028C	0.283015	INO4	YOL028C|YAP7|S000005388|Putative basic leucine zipper (bZIP) transcription factor
YMR193C-A	0.279822	INO4	YMR193C-A||S000004805|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL063C	0.278754	INO4	YKL063C||S000001546|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YGR152C	0.277763	INO4	YGR152C|RSR1|S000003384|GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YJL187C	0.277542	INO4	YJL187C|SWE1|S000003723|Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YHR117W	0.275868	INO4	YHR117W|TOM71|S000001159|Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins
YEL027W	0.274995	INO4	YEL027W|CUP5|S000000753|Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YNL132W	0.274018	INO4	YNL132W|KRE33|S000005076|Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YNR003C	0.27316	INO4	YNR003C|RPC34|S000005286|RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YLR197W	0.271737	INO4	YLR197W|SIK1|S000004187|Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YER133W-A	0.270657	INO4	YER133W-A||S000028756|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YML056C	0.270512	INO4	YML056C|IMD4|S000004520|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YER159C	0.269767	INO4	YER159C|BUR6|S000000961|Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YBR238C	0.269746	INO4	YBR238C||S000000442|Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YKL001C	0.268837	INO4	YKL001C|MET14|S000001484|Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YOR286W	0.2685	INO4	YOR286W|AIM42|S000005812|Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media
YDR303C	0.268337	INO4	YDR303C|RSC3|S000002711|Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
YOL059W	0.267845	INO4	YOL059W|GPD2|S000005420|NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria
YDR129C	0.266354	INO4	YDR129C|SAC6|S000002536|Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YGL005C	0.266282	INO4	YGL005C|COG7|S000002973|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDR012W	0.262579	INO4	YDR012W|RPL4B|S000002419|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
YOL022C	0.262024	INO4	YOL022C|TSR4|S000005382|Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA
YJR025C	0.262017	INO4	YJR025C|BNA1|S000003786|3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YJL105W	0.26059	INO4	YJL105W|SET4|S000003641|Protein of unknown function, contains a SET domain
YIL011W	0.260459	INO4	YIL011W|TIR3|S000001273|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YGR240C	0.257441	INO4	YGR240C|PFK1|S000003472|Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YER092W	0.254963	INO4	YER092W|IES5|S000000894|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YDR434W	0.254693	INO4	YDR434W|GPI17|S000002842|Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog
YLR002C	0.251095	INO4	YLR002C|NOC3|S000003992|Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YDR361C	0.250651	INO4	YDR361C|BCP1|S000002769|Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
YGL257C	0.24939	INO4	YGL257C|MNT2|S000003226|Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
YNL209W	0.248725	INO4	YNL209W|SSB2|S000005153|Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1
YMR008C	0.2485	INO4	YMR008C|PLB1|S000004610|Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YER081W	0.248115	INO4	YER081W|SER3|S000000883|3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p
YPR156C	0.246699	INO4	YPR156C|TPO3|S000006360|Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YHR085W	0.246239	INO4	YHR085W|IPI1|S000001127|Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YLR137W	0.246071	INO4	YLR137W||S000004127|Putative protein of unknown function
YKR013W	0.245057	INO4	YKR013W|PRY2|S000001721|Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YGR103W	0.244802	INO4	YGR103W|NOP7|S000003335|Nucleolar protein involved in rRNA processing and 60S ribosomal subunit biogenesis; constituent of several different pre-ribosomal particles; required for exit from G0 and the initiation of cell proliferation
YLR238W	0.24464	INO4	YLR238W|FAR10|S000004228|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate
YBR167C	0.244393	INO4	YBR167C|POP7|S000000371|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YEL051W	0.243636	INO4	YEL051W|VMA8|S000000777|Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YML005W	0.243468	INO4	YML005W|TRM12|S000004464|S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YNL188W	0.242363	INO4	YNL188W|KAR1|S000005132|Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p
YKL060C	0.242083	INO4	YKL060C|FBA1|S000001543|Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress
YDR065W	0.24051	INO4	YDR065W||S000002472|Protein of unknown function, required for vacuolar acidification; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR140W	0.239022	INO4	YHR140W||S000001182|Putative integral membrane protein of unknown function
YMR266W	0.237044	INO4	YMR266W|RSN1|S000004879|Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant
YGR140W	0.235281	INO4	YGR140W|CBF2|S000003372|Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YHR162W	0.23492	INO4	YHR162W||S000001205|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YOR163W	0.233932	INO4	YOR163W|DDP1|S000005689|Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YGR216C	0.229607	INO4	YGR216C|GPI1|S000003448|Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs
YOR103C	0.228888	INO4	YOR103C|OST2|S000005629|Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YBR012C	0.228521	INO4	YBR012C||S000000216|Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
YGR279C	0.226709	INO4	YGR279C|SCW4|S000003511|Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YBR209W	0.226043	INO4	YBR209W||S000000413|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YJL072C	0.22599	INO4	YJL072C|PSF2|S000003608|Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YEL020C-B	0.22493	INO4	YEL020C-B||S000028544|Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YLR355C	0.223468	INO4	YLR355C|ILV5|S000004347|Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YHR046C	0.22195	INO4	YHR046C|INM1|S000001088|Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YOL011W	0.221447	INO4	YOL011W|PLB3|S000005371|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YCL024W	0.221087	INO4	YCL024W|KCC4|S000000529|Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YOR179C	0.220286	INO4	YOR179C|SYC1|S000005705|Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs
YPR008W	0.217326	INO4	YPR008W|HAA1|S000006212|Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; involved in adaptation to weak acid stress
YIL066W-A	0.215862	INO4	YIL066W-A||S000028791|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL029C	0.215525	INO4	YEL029C|BUD16|S000000755|Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YJR043C	0.214607	INO4	YJR043C|POL32|S000003804|Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YGR139W	0.214531	INO4	YGR139W||S000003371|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR534C	0.21396	INO4	YDR534C|FIT1|S000002942|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOL130W	0.213022	INO4	YOL130W|ALR1|S000005490|Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YBR244W	0.211964	INO4	YBR244W|GPX2|S000000448|Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YEL033W	0.211629	INO4	YEL033W|MTC7|S000000759|Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YKR012C	0.211204	INO4	YKR012C||S000001720|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YOR109W	0.211107	INO4	YOR109W|INP53|S000005635|Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains
YOR314W	0.209855	INO4	YOR314W||S000005841|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR177W	0.208577	INO4	YDR177W|UBC1|S000002584|Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response
YNR009W	0.208538	INO4	YNR009W|NRM1|S000005292|Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YDR007W	0.208211	INO4	YDR007W|TRP1|S000002414|Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YJR086W	0.207426	INO4	YJR086W|STE18|S000003846|G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling
YLR357W	0.207413	INO4	YLR357W|RSC2|S000004349|Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
YJL111W	0.207009	INO4	YJL111W|CCT7|S000003647|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YKR003W	0.206716	INO4	YKR003W|OSH6|S000001711|Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery
YGL034C	0.206542	INO4	YGL034C||S000003002|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR276C	0.206392	INO4	YDR276C|PMP3|S000002684|Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YGR123C	0.205308	INO4	YGR123C|PPT1|S000003355|Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YIR020C-B	0.204978	INO4	YIR020C-B||S000028800|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1
YFL014W	0.204888	INO4	YFL014W|HSP12|S000001880|Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YIL051C	0.204132	INO4	YIL051C|MMF1|S000001313|Mitochondrial protein involved in maintenance of the mitochondrial genome
YDR412W	0.203951	INO4	YDR412W|RRP17|S000002820|Component of the pre-60S pre-ribosomal particle; required for cell viability
YNR061C	0.202252	INO4	YNR061C||S000005344|Putative protein of unknown function
YHR049W	0.201808	INO4	YHR049W|FSH1|S000001091|Serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to Fsh2p and Fsh3p
YDR288W	0.2011	INO4	YDR288W|NSE3|S000002696|Essential subunit of the Mms21-Smc5-Smc6 complex; protein of unknown function; required for DNA repair and growth
YDR047W	0.200377	INO4	YDR047W|HEM12|S000002454|Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YGR169C	0.200248	INO4	YGR169C|PUS6|S000003401|Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability
YKR010C	0.199135	INO4	YKR010C|TOF2|S000001718|Nonessential mitochondrial protein of unknown function with sequence similarity to Net1p; identified as a topoisomerase I (Top1p) binding protein; displays synthetic genetic interactions with TOP1 and HPR1
YLR380W	0.197345	INO4	YLR380W|CSR1|S000004372|Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
YBR042C	0.197296	INO4	YBR042C|CST26|S000000246|Protein of unknown function, affects chromosome stability when overexpressed
YBR080C	0.195637	INO4	YBR080C|SEC18|S000000284|ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF
YBR267W	0.194847	INO4	YBR267W|REI1|S000000471|Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
YML071C	0.19443	INO4	YML071C|COG8|S000004536|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YHR173C	0.192062	INO4	YHR173C||S000001216|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL124W	0.190561	INO4	YIL124W|AYR1|S000001386|NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
YOR174W	0.19034	INO4	YOR174W|MED4|S000005700|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YMR247C	0.189348	INO4	YMR247C|RKR1|S000004861|Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene
YGR124W	0.189145	INO4	YGR124W|ASN2|S000003356|Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YPL132W	0.188134	INO4	YPL132W|COX11|S000006053|Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
YER180C-A	0.187671	INO4	YER180C-A|SLO1|S000028437|Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
YEL046C	0.187049	INO4	YEL046C|GLY1|S000000772|Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YGR130C	0.186364	INO4	YGR130C||S000003362|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YLL038C	0.185757	INO4	YLL038C|ENT4|S000003961|Protein of unknown function, contains an N-terminal epsin-like domain
YCL023C	0.184643	INO4	YCL023C||S000000528|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YMR082C	0.184095	INO4	YMR082C||S000004687|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL186W	0.18335	INO4	YJL186W|MNN5|S000003722|Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YGL116W	0.182639	INO4	YGL116W|CDC20|S000003084|Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate
YCR090C	0.18226	INO4	YCR090C||S000000686|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
YBR086C	0.181289	INO4	YBR086C|IST2|S000000290|Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process
YIL123W	0.180598	INO4	YIL123W|SIM1|S000001385|Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YOR146W	0.180094	INO4	YOR146W||S000005672|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YLR351C	0.180011	INO4	YLR351C|NIT3|S000004343|Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YJR056C	0.179866	INO4	YJR056C||S000003817|Hypothetical protein
YOL155C	0.179746	INO4	YOL155C|HPF1|S000005515|Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YDL051W	0.178572	INO4	YDL051W|LHP1|S000002209|RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YIL043C	0.178357	INO4	YIL043C|CBR1|S000001305|Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia
YGR275W	0.177568	INO4	YGR275W|RTT102|S000003507|Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition
YJR032W	0.177128	INO4	YJR032W|CPR7|S000003793|Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YCR075C	0.175687	INO4	YCR075C|ERS1|S000000671|Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains
YDL092W	0.175614	INO4	YDL092W|SRP14|S000002250|Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14
YLR261C	0.174482	INO4	YLR261C|VPS63|S000004251|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YKR020W	0.172194	INO4	YKR020W|VPS51|S000001728|Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p
YER064C	0.172112	INO4	YER064C||S000000866|Non-essential nuclear protein; null mutation has global effects on transcription
YMR184W	0.170061	INO4	YMR184W|ADD37|S000004796|Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
YMR305C	0.167624	INO4	YMR305C|SCW10|S000004921|Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YOR313C	0.166933	INO4	YOR313C|SPS4|S000005840|Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YDR190C	0.166396	INO4	YDR190C|RVB1|S000002598|Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family
YGL155W	0.166389	INO4	YGL155W|CDC43|S000003123|Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
YNR025C	0.165489	INO4	YNR025C||S000005308|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase
YJL074C	0.16525	INO4	YJL074C|SMC3|S000003610|Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
YCR098C	0.164334	INO4	YCR098C|GIT1|S000000695|Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability
YFR028C	0.164331	INO4	YFR028C|CDC14|S000001924|Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
YER032W	0.163739	INO4	YER032W|FIR1|S000000834|Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate
YNL038W	0.162149	INO4	YNL038W|GPI15|S000004983|Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein
YOR009W	0.161469	INO4	YOR009W|TIR4|S000005535|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock
YBR085C-A	0.161416	INO4	YBR085C-A||S000007522|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YPR185W	0.160968	INO4	YPR185W|ATG13|S000006389|Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
YDR363W-A	0.160524	INO4	YDR363W-A|SEM1|S000007235|Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
YNR071C	0.160118	INO4	YNR071C||S000005354|Putative protein of unknown function
YOR362C	0.159579	INO4	YOR362C|PRE10|S000005889|Alpha 7 subunit of the 20S proteasome
YDL048C	0.156345	INO4	YDL048C|STP4|S000002206|Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YJL209W	0.156115	INO4	YJL209W|CBP1|S000003745|Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p
YMR125W	0.155771	INO4	YMR125W|STO1|S000004732|Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
YDR261C	0.155021	INO4	YDR261C|EXG2|S000002669|Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YJL073W	0.153911	INO4	YJL073W|JEM1|S000003609|DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
YNL208W	0.153566	INO4	YNL208W||S000005152|Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi
YLR026C	0.152311	INO4	YLR026C|SED5|S000004016|cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
YOL054W	0.15088	INO4	YOL054W|PSH1|S000005415|Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein
YGR076C	0.150468	INO4	YGR076C|MRPL25|S000003308|Mitochondrial ribosomal protein of the large subunit
YMR135W-A	0.14941	INO4	YMR135W-A||S000004743|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL116W	0.149329	INO4	YDL116W|NUP84|S000002274|Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis
YIL116W	0.147911	INO4	YIL116W|HIS5|S000001378|Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YHR047C	0.145211	INO4	YHR047C|AAP1|S000001089|Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YDL019C	0.144339	INO4	YDL019C|OSH2|S000002177|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YLR447C	0.144089	INO4	YLR447C|VMA6|S000004439|Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane
YOR145C	0.143981	INO4	YOR145C|PNO1|S000005671|Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain
YDL100C	0.141915	INO4	YDL100C|GET3|S000002258|Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking; has low-level ATPase activity and is involved in resistance to heat and metal stress
YNL259C	0.141905	INO4	YNL259C|ATX1|S000005203|Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake
YPR056W	0.141074	INO4	YPR056W|TFB4|S000006260|Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p
YOR104W	0.14019	INO4	YOR104W|PIN2|S000005630|Protein that induces appearance of [PIN+] prion when overproduced
YML006C	0.139862	INO4	YML006C|GIS4|S000004465|CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YEL047C	0.139389	INO4	YEL047C||S000000773|Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YDR046C	0.137983	INO4	YDR046C|BAP3|S000002453|Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YPR144C	0.137546	INO4	YPR144C|NOC4|S000006348|Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YIL094C	0.136484	INO4	YIL094C|LYS12|S000001356|Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
YLR050C	0.13606	INO4	YLR050C||S000004040|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene
YDR535C	0.135774	INO4	YDR535C||S000002943|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YGR247W	0.134693	INO4	YGR247W|CPD1|S000003479|Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression
YER133W	0.133047	INO4	YER133W|GLC7|S000000935|Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
YDR088C	0.131263	INO4	YDR088C|SLU7|S000002495|RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YOR165W	0.131094	INO4	YOR165W|SEY1|S000005691|Protein of unknown function, contains two predicted GTP-binding motifs GXXXXGKS and DXXG near the N-terminus, homolog of the Arabidopsis gene RHD3 (Root Hair Defective)
YDR487C	0.130376	INO4	YDR487C|RIB3|S000002895|3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration
YGL199C	0.13033	INO4	YGL199C||S000003167|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
YGR099W	0.129784	INO4	YGR099W|TEL2|S000003331|Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect
YOR013W	0.129728	INO4	YOR013W|IRC11|S000005539|Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YIL008W	0.129435	INO4	YIL008W|URM1|S000001270|Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YLR039C	0.128993	INO4	YLR039C|RIC1|S000004029|Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
YDL185C-A	0.127751	INO4	YDL185C-A||S000007600|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species
YPR112C	0.127225	INO4	YPR112C|MRD1|S000006316|Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains
YLR224W	0.125281	INO4	YLR224W||S000004214|F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene
YDR056C	0.125085	INO4	YDR056C||S000002463|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDR056C is not an essential protein
YPR035W	0.124969	INO4	YPR035W|GLN1|S000006239|Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
YBR168W	0.124743	INO4	YBR168W|PEX32|S000000372|Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
YBR022W	0.124591	INO4	YBR022W|POA1|S000000226|Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing
YBR015C	0.122596	INO4	YBR015C|MNN2|S000000219|Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YLR412W	0.122142	INO4	YLR412W|BER1|S000004404|Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
YFR002W	0.121805	INO4	YFR002W|NIC96|S000001898|Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p
YBR202W	0.120367	INO4	YBR202W|MCM7|S000000406|Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YGL161C	0.118497	INO4	YGL161C|YIP5|S000003129|Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YER182W	0.118104	INO4	YER182W|FMP10|S000000984|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER176W	0.117844	INO4	YER176W|ECM32|S000000978|DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes
YOL134C	0.116559	INO4	YOL134C||S000005494|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
YBR217W	0.115122	INO4	YBR217W|ATG12|S000000421|Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
YJR007W	0.114218	INO4	YJR007W|SUI2|S000003767|Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP
YGR259C	0.114066	INO4	YGR259C||S000003491|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YNL238W	0.112796	INO4	YNL238W|KEX2|S000005182|Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
YBR028C	0.112684	INO4	YBR028C||S000000232|Putative protein kinase, possible substrate of cAMP-dependent protein kinase (PKA)
YHL038C	0.108397	INO4	YHL038C|CBP2|S000001030|Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
YBL018C	0.108243	INO4	YBL018C|POP8|S000000114|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YML054C-A	0.108208	INO4	YML054C-A||S000028573|Putative protein of unknown function
YKL114C	0.107849	INO4	YKL114C|APN1|S000001597|Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
YEL042W	0.107368	INO4	YEL042W|GDA1|S000000768|Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate
YER113C	0.106393	INO4	YER113C|TMN3|S000000915|Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation
YPR131C	0.104276	INO4	YPR131C|NAT3|S000006335|Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met
YPL122C	0.104199	INO4	YPL122C|TFB2|S000006043|Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH
YPL049C	0.103975	INO4	YPL049C|DIG1|S000005970|Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YGR287C	0.103616	INO4	YGR287C||S000003519|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YMR043W	0.10361	INO4	YMR043W|MCM1|S000004646|Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
YOR033C	0.102744	INO4	YOR033C|EXO1|S000005559|5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains
YPL255W	0.102705	INO4	YPL255W|BBP1|S000006176|Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YLR415C	0.10242	INO4	YLR415C||S000004407|Putative protein of unknown function; YLR415C is not an essential gene
YGR146C-A	0.102114	INO4	YGR146C-A||S000028638|Putative protein of unknown function
YDR179W-A	0.102061	INO4	YDR179W-A||S000002587|Putative protein of unknown function
YDR215C	0.101617	INO4	YDR215C||S000002623|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YMR315W	0.101363	INO4	YMR315W||S000004932|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene
YBR163W	0.0994466	INO4	YBR163W|DEM1|S000000367|Mitochondrial protein of unknown function; null mutant has defects in cell morphology and in response to air drying; may be regulated by the transcription factor Ace2
YDR213W	0.0991576	INO4	YDR213W|UPC2|S000002621|Sterol regulatory element binding protein, induces transcription of sterol transport and biosynthetic genes; involved in the anaerobic induction of DAN/TIR mannoproteins and seripauperins; binucleate zinc cluster protein; Ecm22p homolog
YPR175W	0.0991481	INO4	YPR175W|DPB2|S000006379|Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate
YJR010C-A	0.0988548	INO4	YJR010C-A|SPC1|S000003770|Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex
YBL026W	0.0988267	INO4	YBL026W|LSM2|S000000122|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YML082W	0.0986416	INO4	YML082W||S000004547|Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YKR090W	0.0982121	INO4	YKR090W|PXL1|S000001798|LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin
YER109C	0.0981605	INO4	YER109C|FLO8|S000000911|Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YML012W	0.0972977	INO4	YML012W|ERV25|S000004473|Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
YGR189C	0.0969407	INO4	YGR189C|CRH1|S000003421|Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YBR243C	0.0956315	INO4	YBR243C|ALG7|S000000447|UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YHR084W	0.0952657	INO4	YHR084W|STE12|S000001126|Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
YOL152W	0.0951351	INO4	YOL152W|FRE7|S000005512|Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YHR134W	0.0948593	INO4	YHR134W|WSS1|S000001176|Sumoylated protein of unknown function, identified based on genetic interactions with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response, processing stalled or collapsed replication forks
YJR060W	0.094585	INO4	YJR060W|CBF1|S000003821|Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA
YGL088W	0.094384	INO4	YGL088W||S000003056|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YDR507C	0.0925949	INO4	YDR507C|GIN4|S000002915|Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p
YDR028C	0.0922693	INO4	YDR028C|REG1|S000002435|Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
YHR001W	0.0915617	INO4	YHR001W|OSH7|S000001043|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YMR218C	0.0915442	INO4	YMR218C|TRS130|S000004831|One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1
YLR227C	0.0908045	INO4	YLR227C|ADY4|S000004217|Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YHR017W	0.0881888	INO4	YHR017W|YSC83|S000001059|Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
YKL097C	0.0855076	INO4	YKL097C||S000001580|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YDR155C	0.0849548	INO4	YDR155C|CPR1|S000002562|Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A
YIL046W-A	0.0846827	INO4	YIL046W-A||S000028836|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YLR112W	0.0843097	INO4	YLR112W||S000004102|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL055C	0.0833681	INO4	YPL055C|LGE1|S000005976|Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
YEL073C	0.0826847	INO4	YEL073C||S000000799|Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline
YPL170W	0.0825062	INO4	YPL170W|DAP1|S000006091|Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis
YBR067C	0.0825004	INO4	YBR067C|TIP1|S000000271|Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YAL053W	0.0820351	INO4	YAL053W|FLC2|S000000049|Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YDL185W	0.0819623	INO4	YDL185W|TFP1|S000002344|Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
YER149C	0.0812611	INO4	YER149C|PEA2|S000000951|Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth
YIL020C	0.0808356	INO4	YIL020C|HIS6|S000001282|Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YPR168W	0.0801681	INO4	YPR168W|NUT2|S000006372|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription
YGL125W	0.0790379	INO4	YGL125W|MET13|S000003093|Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YMR229C	0.0789078	INO4	YMR229C|RRP5|S000004842|RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome
YHR023W	0.0784305	INO4	YHR023W|MYO1|S000001065|Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively
YBL012C	0.0781541	INO4	YBL012C||S000000108|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR076W	0.0779382	INO4	YDR076W|RAD55|S000002483|Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
YDL157C	0.077242	INO4	YDL157C||S000002316|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR295C	0.0769697	INO4	YDR295C|HDA2|S000002703|Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
YOR151C	0.0767408	INO4	YOR151C|RPB2|S000005677|RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
YGR253C	0.0761987	INO4	YGR253C|PUP2|S000003485|Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YHR179W	0.0761119	INO4	YHR179W|OYE2|S000001222|Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YDR051C	0.0759819	INO4	YDR051C||S000002458|Protein of unknown function; interacts with Hsp82p in two-hybrid assay; deletion confers sensitivity to Nickel
YKR004C	0.0753809	INO4	YKR004C|ECM9|S000001712|Non-essential protein of unknown function
YPL221W	0.0745526	INO4	YPL221W|FLC1|S000006142|Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YPR122W	0.0739692	INO4	YPR122W|AXL1|S000006326|Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
YGR168C	0.0734217	INO4	YGR168C||S000003400|Putative protein of unknown function; YGR168C is not an essential gene
YBR044C	0.0731505	INO4	YBR044C|TCM62|S000000248|Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YOR394C-A	0.0726209	INO4	YOR394C-A||S000028718|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKR051W	0.0723468	INO4	YKR051W||S000001759|Putative protein of unknown function
YMR098C	0.0723201	INO4	YMR098C|ATP25|S000004704|Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YHR004C	0.0716469	INO4	YHR004C|NEM1|S000001046|Catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme, which regulates nuclear growth by controlling recruitment of Pah1p onto promoters of phospholipid biosynthetic genes; required for normal nuclear envelope morphology and sporulation
YLL018C	0.0714551	INO4	YLL018C|DPS1|S000003941|Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YPL081W	0.0712678	INO4	YPL081W|RPS9A|S000006002|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YDR152W	0.0708751	INO4	YDR152W|GIR2|S000002559|Highly-acidic cytoplasmic RWD domain-containing protein of unknown function, sensitive to proteolysis, N-terminal region has high content of acidic amino acid residues, putative IUP (intrinsically unstructured protein)
YER037W	0.070673	INO4	YER037W|PHM8|S000000839|Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p
YHR081W	0.0702303	INO4	YHR081W|LRP1|S000001123|Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YOR119C	0.0696424	INO4	YOR119C|RIO1|S000005645|Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
YIL085C	0.0694921	INO4	YIL085C|KTR7|S000001347|Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YEL037C	0.0693955	INO4	YEL037C|RAD23|S000000763|Protein with ubiquitin-like N terminus, recognizes and binds damaged DNA (with Rad4p) during nucleotide excision repair; regulates Rad4p levels, subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human HR23A and HR23B proteins
YHL013C	0.0677671	INO4	YHL013C|OTU2|S000001005|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization
YGR263C	0.0665859	INO4	YGR263C|SAY1|S000003495|Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YNL158W	0.0640335	INO4	YNL158W|PGA1|S000005102|Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
YMR265C	0.0639103	INO4	YMR265C||S000004878|Putative protein of unknown function
YKL176C	0.0636937	INO4	YKL176C|LST4|S000001659|Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface
YLR336C	0.063297	INO4	YLR336C|SGD1|S000004328|Essential nuclear protein with a possible role in the osmoregulatory glycerol response; interacts with phospholipase C (Plc1p); putative homolog of human NOM1 which is implicated in acute myeloid leukemia
YER178W	0.0632696	INO4	YER178W|PDA1|S000000980|E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
YIL019W	0.0630568	INO4	YIL019W|FAF1|S000001281|Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
YOR002W	0.0625581	INO4	YOR002W|ALG6|S000005528|Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
YKL113C	0.0618095	INO4	YKL113C|RAD27|S000001596|5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
YIL079C	0.0617845	INO4	YIL079C|AIR1|S000001341|RING finger protein that interacts with the arginine methyltransferase Hmt1p to regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air2p
YNL085W	0.0617721	INO4	YNL085W|MKT1|S000005029|Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO endonuclease; involved in propagation of M2 dsRNA satellite of L-A virus; contains a DTG signature typical of retroviral proteases
YMR136W	0.0615204	INO4	YMR136W|GAT2|S000004744|Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
YPR021C	0.0612494	INO4	YPR021C|AGC1|S000006225|Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis
YOR032W-A	0.0607941	INO4	YOR032W-A||S000028710|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR433W	0.0594541	INO4	YDR433W||S000002841|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR053C	0.0593322	INO4	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YOR354C	0.0591399	INO4	YOR354C|MSC6|S000005881|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR089W	0.057529	INO4	YDR089W||S000002496|Protein of unknown function; deletion confers resistance to Nickel
YDL037C	0.0572287	INO4	YDL037C|BSC1|S000002195|Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YGR098C	0.0570669	INO4	YGR098C|ESP1|S000003330|Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p
YDR206W	0.0560876	INO4	YDR206W|EBS1|S000002614|Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
YPR190C	0.05574	INO4	YPR190C|RPC82|S000006394|RNA polymerase III subunit C82
YKR072C	0.0554746	INO4	YKR072C|SIS2|S000001780|Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression
YER062C	0.0553982	INO4	YER062C|HOR2|S000000864|One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
YNL239W	0.0547745	INO4	YNL239W|LAP3|S000005183|Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
YLR105C	0.0532977	INO4	YLR105C|SEN2|S000004095|Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
YDR477W	0.0531787	INO4	YDR477W|SNF1|S000002885|AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
YDR349C	0.052513	INO4	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YBR178W	0.0521165	INO4	YBR178W||S000000382|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C
YML070W	0.0518245	INO4	YML070W|DAK1|S000004535|Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YKL062W	0.0505784	INO4	YKL062W|MSN4|S000001545|Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YBR153W	0.0505231	INO4	YBR153W|RIB7|S000000357|Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway
YJL150W	0.0501831	INO4	YJL150W||S000003686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL273W	0.0501412	INO4	YNL273W|TOF1|S000005217|Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase
YDL052C	0.0499551	INO4	YDL052C|SLC1|S000002210|1-acyl-sn-gylcerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes
YPL135C-A	0.0497764	INO4	YPL135C-A||S000028720|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YML016C	0.049519	INO4	YML016C|PPZ1|S000004478|Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YEL057C	0.0493036	INO4	YEL057C||S000000783|Protein of unknown function involved in telomere maintenance; target of UME6 regulation
YBR183W	0.0488614	INO4	YBR183W|YPC1|S000000387|Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YHR124W	0.0478372	INO4	YHR124W|NDT80|S000001166|Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YKL019W	0.0477966	INO4	YKL019W|RAM2|S000001502|Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
YCR014C	0.04678	INO4	YCR014C|POL4|S000000607|DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta
YDR127W	0.0467149	INO4	YDR127W|ARO1|S000002534|Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
YOR355W	0.0463561	INO4	YOR355W|GDS1|S000005882|Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL044C	0.0462998	INO4	YAL044C|GCV3|S000000042|H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
YHR074W	0.0456115	INO4	YHR074W|QNS1|S000001116|Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide
YBR216C	0.0447296	INO4	YBR216C|YBP1|S000000420|Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress
YOR162C	0.0424352	INO4	YOR162C|YRR1|S000005688|Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes
YBR024W	0.0419195	INO4	YBR024W|SCO2|S000000228|Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YGR097W	0.0416679	INO4	YGR097W|ASK10|S000003329|Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YER016W	0.0414251	INO4	YER016W|BIM1|S000000818|Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YNL123W	0.0402541	INO4	YNL123W|NMA111|S000005067|Protein of unknown function which may contribute to lipid homeostasis and/or apoptosis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
YKR037C	0.0394809	INO4	YKR037C|SPC34|S000001745|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YDR486C	0.0375017	INO4	YDR486C|VPS60|S000002894|Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p
YPL257W	0.0368018	INO4	YPL257W||S000006178|Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YKL017C	0.036194	INO4	YKL017C|HCS1|S000001500|Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities
YPL068C	0.0350597	INO4	YPL068C||S000005989|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS
YIL061C	0.0348732	INO4	YIL061C|SNP1|S000001323|Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein
YOR014W	0.0345591	INO4	YOR014W|RTS1|S000005540|B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
YKR052C	0.0333867	INO4	YKR052C|MRS4|S000001760|Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YOR072W-B	0.0321181	INO4	YOR072W-B||S000028516|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YDR137W	0.031601	INO4	YDR137W|RGP1|S000002544|Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p
YOL003C	0.0315446	INO4	YOL003C|PFA4|S000005363|Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
YLR460C	0.0310521	INO4	YLR460C||S000004452|Putative protein of unknown function, possibly up-regulated by iodine
YJR031C	0.0305341	INO4	YJR031C|GEA1|S000003792|Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p
YPR121W	0.0299173	INO4	YPR121W|THI22|S000006325|Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis
YNL181W	0.0298293	INO4	YNL181W||S000005125|Putative oxidoreductase; required for cell viability
YNL225C	0.0280331	INO4	YNL225C|CNM67|S000005169|Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration
YDL024C	0.0277301	INO4	YDL024C|DIA3|S000002182|Protein of unknown function, involved in invasive and pseudohyphal growth
YBL011W	0.0275881	INO4	YBL011W|SCT1|S000000107|Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
YGL035C	0.0273984	INO4	YGL035C|MIG1|S000003003|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YCL026C-A	0.0261654	INO4	YCL026C-A|FRM2|S000000589|Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; similar to bacterial nitroreductases
YNL073W	0.0260399	INO4	YNL073W|MSK1|S000005017|Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria
YFR013W	0.0259072	INO4	YFR013W|IOC3|S000001909|Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing
YOL033W	0.0254982	INO4	YOL033W|MSE1|S000005393|Mitochondrial glutamyl-tRNA synthetase, encoded by a nuclear gene
YNL097C	0.024286	INO4	YNL097C|PHO23|S000005041|Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; C-terminus has similarity to human candidate tumor suppressor p33(ING1)
YCR075W-A	0.0238315	INO4	YCR075W-A||S000028519|Putative protein of unknown function; identified by homology to Ashbya gossypii
YGR161W-C	0.0226089	INO4	YGR161W-C||S000029726|Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YGR143W	0.0223182	INO4	YGR143W|SKN1|S000003375|Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p
YHL031C	0.0217409	INO4	YHL031C|GOS1|S000001023|v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
YKL068W	0.0217301	INO4	YKL068W|NUP100|S000001551|Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p
YOR076C	0.0213454	INO4	YOR076C|SKI7|S000005602|Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs
YKR031C	0.0212057	INO4	YKR031C|SPO14|S000001739|Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis
YPL095C	0.0211495	INO4	YPL095C|EEB1|S000006016|Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification
YDR162C	0.02104	INO4	YDR162C|NBP2|S000002569|Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p
YDR414C	0.0209749	INO4	YDR414C|ERD1|S000002822|Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)
YDR396W	0.0201386	INO4	YDR396W||S000002804|Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex
YHL030W	0.0200695	INO4	YHL030W|ECM29|S000001022|Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome
YJL160C	0.0191869	INO4	YJL160C||S000003696|Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis
YBR219C	0.0190467	INO4	YBR219C||S000000423|Putative protein of unknown function; YBR219C is not an essential gene
YIL067C	0.0187143	INO4	YIL067C||S000001329|Uncharacterized protein of unknown function
YKL049C	0.0181264	INO4	YKL049C|CSE4|S000001532|Centromere protein that resembles histones, required for proper kinetochore function; homolog of human CENP-A
YDR032C	0.0172931	INO4	YDR032C|PST2|S000002439|Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL064C	0.015452	INO4	YNL064C|YDJ1|S000005008|Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
YNL099C	0.0146945	INO4	YNL099C|OCA1|S000005043|Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
YBL052C	0.0145073	INO4	YBL052C|SAS3|S000000148|Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; sas3 gcn5 double mutation confers lethality
YLR461W	0.0142954	INO4	YLR461W|PAU4|S000004453|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDL059C	0.0124921	INO4	YDL059C|RAD59|S000002217|Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
YGL182C	0.0124692	INO4	YGL182C||S000003150|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C
YIR021W-A	0.0120026	INO4	YIR021W-A||S000028838|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YML130C	0.0119305	INO4	YML130C|ERO1|S000004599|Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
YPL259C	0.0118543	INO4	YPL259C|APM1|S000006180|Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
YDL193W	0.0113359	INO4	YDL193W|NUS1|S000002352|Prenyltransferase, required for cell viability; involved in protein trafficking
YDR228C	0.0101298	INO4	YDR228C|PCF11|S000002636|mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
YNL299W	0.00902124	INO4	YNL299W|TRF5|S000005243|Poly (A) polymerase involved in nuclear RNA quality control based on: homology with Trf4p, genetic interactions with TRF4 mutants, physical interaction with Mtr4p (TRAMP subunit), and by direct assay; disputed role as a sigma DNA polymerase
YIL050W	0.00840319	INO4	YIL050W|PCL7|S000001312|Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YBR079C	0.00836507	INO4	YBR079C|RPG1|S000000283|Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YHR014W	0.00781286	INO4	YHR014W|SPO13|S000001056|Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
YER188W	0.00769259	INO4	YER188W||S000000990|Hypothetical protein
YML041C	0.0068348	INO4	YML041C|VPS71|S000004505|Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YKR073C	0.00678727	INO4	YKR073C||S000001781|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR278W	0.00566719	INO4	YOR278W|HEM4|S000005804|Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway
YPL008W	0.00526378	INO4	YPL008W|CHL1|S000005929|Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p
YOR077W	0.00524118	INO4	YOR077W|RTS2|S000005603|Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
YPR105C	0.00454881	INO4	YPR105C|COG4|S000006309|Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YCL002C	0.00365303	INO4	YCL002C||S000000508|Putative protein of unknown function; YCL002C is not an essential gene
YOR048C	0.00335879	INO4	YOR048C|RAT1|S000005574|Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination
YBR043C	0.00326445	INO4	YBR043C|QDR3|S000000247|Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin
YGL098W	0.00274231	INO4	YGL098W|USE1|S000003066|Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
YDL058W	0.00268054	INO4	YDL058W|USO1|S000002216|Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex
YCL061C	0.00171547	INO4	YCL061C|MRC1|S000000566|S-phase checkpoint protein found at replication forks, required for DNA replication; also required for Rad53p activation during DNA replication stress, where it forms a replication-pausing complex with Tof1p and is phosphorylated by Mec1p
YIL071C	0.00116755	INO4	YIL071C|PCI8|S000001333|Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
YLR113W	0.000931205	INO4	YLR113W|HOG1|S000004103|Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p
YHR059W	0.000492593	INO4	YHR059W|FYV4|S000001101|Protein of unknown function, required for survival upon exposure to K1 killer toxin
