YDL210W	6.89567	GZF3	YDL210W|UGA4|S000002369|Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YER065C	6.47338	GZF3	YER065C|ICL1|S000000867|Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YKR034W	4.88395	GZF3	YKR034W|DAL80|S000001742|Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YAR050W	4.60459	GZF3	YAR050W|FLO1|S000000084|Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YIR027C	3.84452	GZF3	YIR027C|DAL1|S000001466|Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YAR047C	3.69509	GZF3	YAR047C||S000000083|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR296W	3.52312	GZF3	YLR296W||S000004287|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR343C	3.37521	GZF3	YDR343C|HXT6|S000002751|High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YLR142W	3.29702	GZF3	YLR142W|PUT1|S000004132|Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YNL195C	3.24957	GZF3	YNL195C||S000005139|Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL162W	3.22481	GZF3	YIL162W|SUC2|S000001424|Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YMR107W	3.06398	GZF3	YMR107W|SPG4|S000004713|Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YEL059W	2.99673	GZF3	YEL059W||S000000785|Dubious open reading frame unlikely to encode a functional protein
YLR295C	2.91448	GZF3	YLR295C|ATP14|S000004286|Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YHR212C	2.86742	GZF3	YHR212C||S000001255|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL062W	2.85173	GZF3	YAL062W|GDH3|S000000058|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YBL049W	2.81225	GZF3	YBL049W|MOH1|S000000145|Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YNR002C	2.63927	GZF3	YNR002C|ATO2|S000005285|Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YHR212W-A	2.63473	GZF3	YHR212W-A||S000028650|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YOR348C	2.56654	GZF3	YOR348C|PUT4|S000005875|Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YGR144W	2.45917	GZF3	YGR144W|THI4|S000003376|Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YNL144C	2.32893	GZF3	YNL144C||S000005088|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YER014C-A	2.02415	GZF3	YER014C-A|BUD25|S000007590|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YKR015C	1.96505	GZF3	YKR015C||S000001723|Putative protein of unknown function
YPR026W	1.91943	GZF3	YPR026W|ATH1|S000006230|Acid trehalase required for utilization of extracellular trehalose
YLL056C	1.90159	GZF3	YLL056C||S000003979|Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YLL055W	1.86838	GZF3	YLL055W|YCT1|S000003978|High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YER066W	1.86548	GZF3	YER066W||S000000868|Putative protein of unknown function; YER066W is not an essential gene
YMR081C	1.85579	GZF3	YMR081C|ISF1|S000004686|Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YNL142W	1.83707	GZF3	YNL142W|MEP2|S000005086|Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YPR196W	1.70531	GZF3	YPR196W||S000006400|Putative maltose activator
YAR053W	1.68331	GZF3	YAR053W||S000000085|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR346W	1.66229	GZF3	YOR346W|REV1|S000005873|Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YLR297W	1.66141	GZF3	YLR297W||S000004288|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR213C	1.63802	GZF3	YGR213C|RTA1|S000003445|Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YIL146C	1.60852	GZF3	YIL146C|ECM37|S000001408|Non-essential protein of unknown function
YDL138W	1.60803	GZF3	YDL138W|RGT2|S000002297|Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YBR292C	1.58736	GZF3	YBR292C||S000000496|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YLR356W	1.56329	GZF3	YLR356W||S000004348|Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YOR178C	1.53759	GZF3	YOR178C|GAC1|S000005704|Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YJR152W	1.53564	GZF3	YJR152W|DAL5|S000003913|Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YFR053C	1.51158	GZF3	YFR053C|HXK1|S000001949|Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YBL048W	1.50555	GZF3	YBL048W||S000000144|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YLR346C	1.50494	GZF3	YLR346C||S000004338|Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YDL244W	1.50047	GZF3	YDL244W|THI13|S000002403|Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YIR029W	1.49958	GZF3	YIR029W|DAL2|S000001468|Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YOR345C	1.49663	GZF3	YOR345C||S000005872|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YFR029W	1.45459	GZF3	YFR029W|PTR3|S000001925|Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YJL213W	1.44756	GZF3	YJL213W||S000003749|Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YDR034C	1.43055	GZF3	YDR034C|LYS14|S000002441|Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YKR016W	1.42744	GZF3	YKR016W|AIM28|S000001724|Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YBR117C	1.41197	GZF3	YBR117C|TKL2|S000000321|Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YHR139C	1.35905	GZF3	YHR139C|SPS100|S000001181|Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YDR540C	1.35074	GZF3	YDR540C|IRC4|S000002948|Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDL215C	1.32244	GZF3	YDL215C|GDH2|S000002374|NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YAR060C	1.31833	GZF3	YAR060C||S000000086|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR077C	1.27096	GZF3	YBR077C|SLM4|S000000281|Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YMR311C	1.21525	GZF3	YMR311C|GLC8|S000004928|Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2
YJL067W	1.19959	GZF3	YJL067W||S000003603|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL103C	1.18995	GZF3	YKL103C|LAP4|S000001586|Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YOL047C	1.15951	GZF3	YOL047C||S000005407|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YNL125C	1.15097	GZF3	YNL125C|ESBP6|S000005069|Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YER076W-A	1.14712	GZF3	YER076W-A||S000028750|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YER150W	1.12702	GZF3	YER150W|SPI1|S000000952|GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YER084W	1.11989	GZF3	YER084W||S000000886|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR379C	1.10439	GZF3	YOR379C||S000005906|Hypothetical protein
YER076C	1.10419	GZF3	YER076C||S000000878|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YOR066W	1.09444	GZF3	YOR066W|MSA1|S000005592|Activator of G1-specific transcription factors, MBF and SBF, that regulates both the timing of G1-specific gene transcription, and cell cycle initiation; potential Cdc28p substrate
YMR118C	1.07188	GZF3	YMR118C||S000004724|Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YOR382W	1.07159	GZF3	YOR382W|FIT2|S000005909|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YKL217W	1.0699	GZF3	YKL217W|JEN1|S000001700|Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YDL170W	1.03568	GZF3	YDL170W|UGA3|S000002329|Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus
YGR087C	1.02791	GZF3	YGR087C|PDC6|S000003319|Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YIR028W	1.01314	GZF3	YIR028W|DAL4|S000001467|Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YER116C	1.00102	GZF3	YER116C|SLX8|S000000918|Subunit of the Slx5-Slx8 substrate-specific ubiquitin ligase complex; stimulated by prior attachment of SUMO to the substrate
YNL143C	0.988696	GZF3	YNL143C||S000005087|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR231C	0.986492	GZF3	YDR231C|COX20|S000002639|Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
YJR008W	0.986431	GZF3	YJR008W||S000003768|Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source.
YNR034W	0.979298	GZF3	YNR034W|SOL1|S000005317|Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YDR542W	0.978951	GZF3	YDR542W|PAU10|S000002950|Hypothetical protein
YHL046W-A	0.976414	GZF3	YHL046W-A||S000028775|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL015W	0.959387	GZF3	YBL015W|ACH1|S000000111|Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YGR043C	0.94789	GZF3	YGR043C|NQM1|S000003275|Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YJL116C	0.944822	GZF3	YJL116C|NCA3|S000003652|Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YLL039C	0.931031	GZF3	YLL039C|UBI4|S000003962|Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YEL039C	0.928017	GZF3	YEL039C|CYC7|S000000765|Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YMR170C	0.917638	GZF3	YMR170C|ALD2|S000004780|Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YOR152C	0.902413	GZF3	YOR152C||S000005678|Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YKR032W	0.897393	GZF3	YKR032W||S000001740|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL094C	0.895524	GZF3	YBL094C||S000000190|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W
YOL128C	0.895024	GZF3	YOL128C|YGK3|S000005488|Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation
YHL047C	0.892015	GZF3	YHL047C|ARN2|S000001039|Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YGR201C	0.887127	GZF3	YGR201C||S000003433|Putative protein of unknown function
YBL039W-B	0.886159	GZF3	YBL039W-B||S000028517|Putative protein of unknown function
YEL024W	0.884296	GZF3	YEL024W|RIP1|S000000750|Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YHR199C	0.882111	GZF3	YHR199C|AIM46|S000001242|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YKR097W	0.879107	GZF3	YKR097W|PCK1|S000001805|Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YML042W	0.877787	GZF3	YML042W|CAT2|S000004506|Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YNL176C	0.877647	GZF3	YNL176C||S000005120|Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p
YCR068W	0.869549	GZF3	YCR068W|ATG15|S000000664|Lipase, required for intravacuolar lysis of autophagosomes; located in the endoplasmic reticulum membrane and targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway
YOL163W	0.864552	GZF3	YOL163W||S000005523|Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YPL089C	0.856342	GZF3	YPL089C|RLM1|S000006010|MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YLR332W	0.84304	GZF3	YLR332W|MID2|S000004324|O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YOR380W	0.842257	GZF3	YOR380W|RDR1|S000005907|Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
YJL045W	0.83487	GZF3	YJL045W||S000003581|Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YCL066W	0.833012	GZF3	YCL066W|HMLALPHA1|S000000571|Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression
YKL102C	0.822421	GZF3	YKL102C||S000001585|Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YPL236C	0.81827	GZF3	YPL236C||S000006157|Putative protein kinase that exhibits Akr1p-dependent palmitoylation
YBR056W-A	0.817538	GZF3	YBR056W-A||S000028736|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YAL063C	0.815546	GZF3	YAL063C|FLO9|S000000059|Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YLL053C	0.814857	GZF3	YLL053C||S000003976|Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YLR331C	0.809058	GZF3	YLR331C|JIP3|S000004323|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YCL025C	0.800923	GZF3	YCL025C|AGP1|S000000530|Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YCR021C	0.800568	GZF3	YCR021C|HSP30|S000000615|Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YGL096W	0.798502	GZF3	YGL096W|TOS8|S000003064|Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YEL060C	0.798499	GZF3	YEL060C|PRB1|S000000786|Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation
YDR262W	0.791501	GZF3	YDR262W||S000002670|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
YNL101W	0.78272	GZF3	YNL101W|AVT4|S000005045|Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YFR017C	0.780409	GZF3	YFR017C||S000001913|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YOR003W	0.771663	GZF3	YOR003W|YSP3|S000005529|Putative precursor to the subtilisin-like protease III
YCL067C	0.771533	GZF3	YCL067C|HMLALPHA2|S000000572|Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression
YJR096W	0.768102	GZF3	YJR096W||S000003857|Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YBL078C	0.760676	GZF3	YBL078C|ATG8|S000000174|Conserved protein that is a component of autophagosomes and Cvt vesicles; undergoes C-terminal conjugation to phosphatidylethanolamine (PE), Atg8p-PE is anchored to membranes and may mediate membrane fusion during autophagosome formation
YCL048W	0.759374	GZF3	YCL048W|SPS22|S000000553|Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YLR299W	0.759146	GZF3	YLR299W|ECM38|S000004290|Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
YNL018C	0.75379	GZF3	YNL018C||S000004963|Putative protein of unknown function
YHR126C	0.752614	GZF3	YHR126C||S000001168|Putative protein of unknown function; transcription dependent upon Azf1p
YOR173W	0.752469	GZF3	YOR173W|DCS2|S000005699|Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YKR049C	0.750368	GZF3	YKR049C|FMP46|S000001757|Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR202W	0.74129	GZF3	YHR202W||S000001245|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YKR039W	0.740755	GZF3	YKR039W|GAP1|S000001747|General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YGR129W	0.737087	GZF3	YGR129W|SYF2|S000003361|Component of the spliceosome complex involved in pre-mRNA splicing; involved in regulation of cell cycle progression
YEL059C-A	0.734476	GZF3	YEL059C-A|SOM1|S000002954|Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates
YBR293W	0.733611	GZF3	YBR293W|VBA2|S000000497|Permease of basic amino acids in the vacuolar membrane
YFL051C	0.731405	GZF3	YFL051C||S000001843|Putative protein of unknown function; YFL051C is not an essential gene
YIL099W	0.728415	GZF3	YIL099W|SGA1|S000001361|Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YDR342C	0.717959	GZF3	YDR342C|HXT7|S000002750|High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YOL052C-A	0.715224	GZF3	YOL052C-A|DDR2|S000005413|Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YDR541C	0.715179	GZF3	YDR541C||S000002949|Putative dihydrokaempferol 4-reductase
YHR189W	0.712872	GZF3	YHR189W|PTH1|S000001232|One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respiration
YLL052C	0.71017	GZF3	YLL052C|AQY2|S000003975|Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YAR070C	0.709379	GZF3	YAR070C||S000000093|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR069C	0.704459	GZF3	YAR069C||S000000092|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR078W	0.700005	GZF3	YJR078W|BNA2|S000003839|Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YFL063W	0.695694	GZF3	YFL063W||S000001831|Dubious open reading frame, based on available experimental and comparative sequence data
YGR244C	0.686874	GZF3	YGR244C|LSC2|S000003476|Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate
YDR092W	0.67668	GZF3	YDR092W|UBC13|S000002499|Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus
YHL016C	0.675688	GZF3	YHL016C|DUR3|S000001008|Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
YLR164W	0.675665	GZF3	YLR164W||S000004154|Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YJL103C	0.671516	GZF3	YJL103C|GSM1|S000003639|Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YPR001W	0.661244	GZF3	YPR001W|CIT3|S000006205|Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YLL018C-A	0.660358	GZF3	YLL018C-A|COX19|S000007245|Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase
YPL088W	0.655351	GZF3	YPL088W||S000006009|Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YHR211W	0.650509	GZF3	YHR211W|FLO5|S000001254|Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YDL182W	0.650001	GZF3	YDL182W|LYS20|S000002341|Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YPL234C	0.647865	GZF3	YPL234C|TFP3|S000006155|Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen
YGR281W	0.647138	GZF3	YGR281W|YOR1|S000003513|Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin
YDL245C	0.646357	GZF3	YDL245C|HXT15|S000002404|Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR059C	0.640502	GZF3	YDR059C|UBC5|S000002466|Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YPR160W	0.633387	GZF3	YPR160W|GPH1|S000006364|Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YKR102W	0.623722	GZF3	YKR102W|FLO10|S000001810|Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YKR009C	0.61105	GZF3	YKR009C|FOX2|S000001717|Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YHR096C	0.610712	GZF3	YHR096C|HXT5|S000001138|Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YKL163W	0.610231	GZF3	YKL163W|PIR3|S000001646|O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YAR068W	0.606087	GZF3	YAR068W||S000000091|Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YDR232W	0.604444	GZF3	YDR232W|HEM1|S000002640|5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p
YPL135W	0.596424	GZF3	YPL135W|ISU1|S000006056|Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YJR128W	0.591864	GZF3	YJR128W||S000003889|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YOR387C	0.590193	GZF3	YOR387C||S000005914|Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction
YBR296C	0.586973	GZF3	YBR296C|PHO89|S000000500|Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YMR068W	0.586921	GZF3	YMR068W|AVO2|S000004672|Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YAR023C	0.58635	GZF3	YAR023C||S000000074|Putative integral membrane protein, member of DUP240 gene family
YFL021W	0.582596	GZF3	YFL021W|GAT1|S000001873|Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p
YDR528W	0.581974	GZF3	YDR528W|HLR1|S000002936|Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YLR259C	0.576593	GZF3	YLR259C|HSP60|S000004249|Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YDL139C	0.574568	GZF3	YDL139C|SCM3|S000002298|Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YAL067C	0.571033	GZF3	YAL067C|SEO1|S000000062|Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YCL054W	0.561975	GZF3	YCL054W|SPB1|S000000559|AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YGR088W	0.559425	GZF3	YGR088W|CTT1|S000003320|Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YER188C-A	0.55503	GZF3	YER188C-A||S000028764|Putative protein of unknown function
YBR291C	0.551502	GZF3	YBR291C|CTP1|S000000495|Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
YOR376W	0.548955	GZF3	YOR376W||S000005903|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YFL064C	0.547731	GZF3	YFL064C||S000001830|Putative protein of unknown function
YDL169C	0.542614	GZF3	YDL169C|UGX2|S000002328|Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YEL072W	0.540169	GZF3	YEL072W|RMD6|S000000798|Protein required for sporulation
YDR379C-A	0.538597	GZF3	YDR379C-A||S000007605|Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YJR150C	0.5384	GZF3	YJR150C|DAN1|S000003911|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YMR040W	0.534615	GZF3	YMR040W|YET2|S000004643|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YKL065W-A	0.532612	GZF3	YKL065W-A||S000113563|Putative protein of unknown function
YDR277C	0.532372	GZF3	YDR277C|MTH1|S000002685|Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YOR338W	0.53191	GZF3	YOR338W||S000005865|Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen
YDL238C	0.525643	GZF3	YDL238C|GUD1|S000002397|Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YPL054W	0.521597	GZF3	YPL054W|LEE1|S000005975|Zinc-finger protein of unknown function
YNR011C	0.517654	GZF3	YNR011C|PRP2|S000005294|RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing
YKL192C	0.517241	GZF3	YKL192C|ACP1|S000001675|Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p
YNL117W	0.513349	GZF3	YNL117W|MLS1|S000005061|Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YNL036W	0.50791	GZF3	YNL036W|NCE103|S000004981|Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YBR101C	0.504435	GZF3	YBR101C|FES1|S000000305|Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum
YGR197C	0.503757	GZF3	YGR197C|SNG1|S000003429|Protein involved in nitrosoguanidine (MNNG) resistance; expression is regulated by transcription factors involved in multidrug resistance
YNL104C	0.503728	GZF3	YNL104C|LEU4|S000005048|Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway
YGL072C	0.501936	GZF3	YGL072C||S000003040|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YDR479C	0.497846	GZF3	YDR479C|PEX29|S000002887|Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YPL147W	0.495803	GZF3	YPL147W|PXA1|S000006068|Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YER033C	0.491907	GZF3	YER033C|ZRG8|S000000835|Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YKL086W	0.491025	GZF3	YKL086W|SRX1|S000001569|Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotes
YDR406W	0.487882	GZF3	YDR406W|PDR15|S000002814|Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YIL047C	0.484884	GZF3	YIL047C|SYG1|S000001309|Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YOL081W	0.483095	GZF3	YOL081W|IRA2|S000005441|GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YDR298C	0.481958	GZF3	YDR298C|ATP5|S000002706|Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YPL031C	0.477876	GZF3	YPL031C|PHO85|S000005952|Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle
YEL009C-A	0.477644	GZF3	YEL009C-A||S000028741|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER187W	0.474168	GZF3	YER187W||S000000989|Putative protein of unknown function; induced in respiratory-deficient cells
YIL101C	0.473945	GZF3	YIL101C|XBP1|S000001363|Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YPL271W	0.473591	GZF3	YPL271W|ATP15|S000006192|Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YHR006W	0.473244	GZF3	YHR006W|STP2|S000001048|Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YDR114C	0.473192	GZF3	YDR114C||S000002521|Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
YFL062W	0.472539	GZF3	YFL062W|COS4|S000001832|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOL051W	0.469028	GZF3	YOL051W|GAL11|S000005411|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YGL191W	0.467158	GZF3	YGL191W|COX13|S000003159|Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YDR175C	0.456103	GZF3	YDR175C|RSM24|S000002582|Mitochondrial ribosomal protein of the small subunit
YJL163C	0.456012	GZF3	YJL163C||S000003699|Putative protein of unknown function
YKL038W	0.455345	GZF3	YKL038W|RGT1|S000001521|Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YOL100W	0.44725	GZF3	YOL100W|PKH2|S000005460|Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p
YIL066C	0.446877	GZF3	YIL066C|RNR3|S000001328|One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YPR111W	0.444806	GZF3	YPR111W|DBF20|S000006315|Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis
YBR021W	0.444562	GZF3	YBR021W|FUR4|S000000225|Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues
YJR112W-A	0.444327	GZF3	YJR112W-A||S000028513|Putative protein of unknown function; identified based on homology to Ashbya gossypii
YLR352W	0.441648	GZF3	YLR352W||S000004344|Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene
YCR007C	0.434419	GZF3	YCR007C||S000000600|Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YDR313C	0.431713	GZF3	YDR313C|PIB1|S000002721|RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YNL094W	0.428745	GZF3	YNL094W|APP1|S000005038|Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization
YHL036W	0.42871	GZF3	YHL036W|MUP3|S000001028|Low affinity methionine permease, similar to Mup1p
YMR135C	0.423546	GZF3	YMR135C|GID8|S000004742|Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YOL118C	0.423027	GZF3	YOL118C||S000005478|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YDL183C	0.422632	GZF3	YDL183C||S000002342|Putative protein of unknown function; YDL183C is not an essential gene
YER189W	0.421317	GZF3	YER189W||S000000991|Putative protein of unknown function
YPL023C	0.412322	GZF3	YPL023C|MET12|S000005944|Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YOR378W	0.411083	GZF3	YOR378W||S000005905|Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YER024W	0.41061	GZF3	YER024W|YAT2|S000000826|Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YMR180C	0.410225	GZF3	YMR180C|CTL1|S000004792|RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm
YNL005C	0.407243	GZF3	YNL005C|MRP7|S000004950|Mitochondrial ribosomal protein of the large subunit
YLR312C	0.406365	GZF3	YLR312C|QNQ1|S000004303|Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YGL258W-A	0.406163	GZF3	YGL258W-A||S000007607|Putative protein of unknown function
YBR083W	0.405008	GZF3	YBR083W|TEC1|S000000287|Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member
YJL155C	0.400244	GZF3	YJL155C|FBP26|S000003691|Fructose-2,6-bisphosphatase, required for glucose metabolism
YEL028W	0.398385	GZF3	YEL028W||S000000754|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL084W	0.397913	GZF3	YOL084W|PHM7|S000005444|Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YHR217C	0.39636	GZF3	YHR217C||S000001260|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YPL203W	0.391383	GZF3	YPL203W|TPK2|S000006124|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk3p
YJL102W	0.388823	GZF3	YJL102W|MEF2|S000003638|Mitochondrial elongation factor involved in translational elongation
YMR139W	0.384882	GZF3	YMR139W|RIM11|S000004747|Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta
YNL091W	0.382951	GZF3	YNL091W|NST1|S000005035|Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YKL028W	0.382427	GZF3	YKL028W|TFA1|S000001511|TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
YIL057C	0.382079	GZF3	YIL057C||S000001319|Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YCR091W	0.380542	GZF3	YCR091W|KIN82|S000000687|Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YDL194W	0.377968	GZF3	YDL194W|SNF3|S000002353|Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YBR147W	0.374836	GZF3	YBR147W|RTC2|S000000351|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays fluconazole resistance and suppresses cdc13-1 temperature sensitivity
YEL012W	0.373983	GZF3	YEL012W|UBC8|S000000738|Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YNL133C	0.370411	GZF3	YNL133C|FYV6|S000005077|Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YGR102C	0.368756	GZF3	YGR102C||S000003334|Putative protein of unknown function; transposon insertion mutant is salt sensitive and deletion mutant has growth defects; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR210C	0.3685	GZF3	YHR210C||S000001253|Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10
YPR010C-A	0.365125	GZF3	YPR010C-A||S000122558|Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YNL103W	0.363186	GZF3	YNL103W|MET4|S000005047|Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YDL088C	0.363134	GZF3	YDL088C|ASM4|S000002246|Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p
YLR377C	0.362957	GZF3	YLR377C|FBP1|S000004369|Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YDR043C	0.360829	GZF3	YDR043C|NRG1|S000002450|Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YAL056W	0.360797	GZF3	YAL056W|GPB2|S000000052|Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p
YPL262W	0.357214	GZF3	YPL262W|FUM1|S000006183|Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation; phosphorylated in mitochondria
YMR312W	0.357069	GZF3	YMR312W|ELP6|S000004929|Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
YDR115W	0.356475	GZF3	YDR115W||S000002522|Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins
YMR096W	0.356169	GZF3	YMR096W|SNZ1|S000004702|Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
YHR048W	0.35537	GZF3	YHR048W|YHK8|S000001090|Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YOR211C	0.354618	GZF3	YOR211C|MGM1|S000005737|Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YGL140C	0.354466	GZF3	YGL140C||S000003108|Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains
YIL045W	0.354241	GZF3	YIL045W|PIG2|S000001307|Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YJL068C	0.353907	GZF3	YJL068C||S000003604|Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
YIR030C	0.3527	GZF3	YIR030C|DCG1|S000001469|Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain
YCR040W	0.3516	GZF3	YCR040W|MATALPHA1|S000000636|Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette
YJR077C	0.349269	GZF3	YJR077C|MIR1|S000003838|Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YML083C	0.349137	GZF3	YML083C||S000004548|Putative protein of unknown function; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
YHR139C-A	0.347561	GZF3	YHR139C-A||S000003533|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL006W	0.345824	GZF3	YEL006W|YEA6|S000000732|Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog
YER119C	0.345113	GZF3	YER119C|AVT6|S000000921|Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YMR257C	0.344796	GZF3	YMR257C|PET111|S000004870|Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
YDL010W	0.344524	GZF3	YDL010W|GRX6|S000002168|Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YHR180W	0.341188	GZF3	YHR180W||S000001223|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL139W	0.340158	GZF3	YGL139W|FLC3|S000003107|Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER
YDR179C	0.339576	GZF3	YDR179C|CSN9|S000002586|Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
YEL010W	0.338803	GZF3	YEL010W||S000000736|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR206W	0.337235	GZF3	YMR206W||S000004819|Putative protein of unknown function; YMR206W is not an essential gene
YLR235C	0.336217	GZF3	YLR235C||S000004225|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3
YKL148C	0.335991	GZF3	YKL148C|SDH1|S000001631|Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YBR201C-A	0.335694	GZF3	YBR201C-A||S000087085|Putative protein of unknown function
YLR236C	0.3337	GZF3	YLR236C||S000004226|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR284W	0.331382	GZF3	YBR284W||S000000488|Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YGL066W	0.331165	GZF3	YGL066W|SGF73|S000003034|Subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters; null mutant displays defects in premeiotic DNA synthesis
YDL011C	0.330884	GZF3	YDL011C||S000002169|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YDR036C	0.330199	GZF3	YDR036C|EHD3|S000002443|3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YKL095W	0.32928	GZF3	YKL095W|YJU2|S000001578|Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ("nineteen complex") and acts after Prp2p to promote the first catalytic reaction of splicing
YLR237W	0.329241	GZF3	YLR237W|THI7|S000004227|Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YJR138W	0.328637	GZF3	YJR138W|IML1|S000003899|Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YPL048W	0.326106	GZF3	YPL048W|CAM1|S000005969|Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
YBR108W	0.323121	GZF3	YBR108W|AIM3|S000000312|Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YCR039C	0.32284	GZF3	YCR039C|MATALPHA2|S000000635|Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette
YDR536W	0.322719	GZF3	YDR536W|STL1|S000002944|Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YGR268C	0.318781	GZF3	YGR268C|HUA1|S000003500|Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YPR151C	0.318378	GZF3	YPR151C|SUE1|S000006355|Mitochondrial protein required for degradation of unstable forms of cytochrome c
YBR072W	0.317699	GZF3	YBR072W|HSP26|S000000276|Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YOR208W	0.316272	GZF3	YOR208W|PTP2|S000005734|Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
YKL177W	0.315843	GZF3	YKL177W||S000001660|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YPL022W	0.313321	GZF3	YPL022W|RAD1|S000005943|Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
YHL023C	0.312296	GZF3	YHL023C|RMD11|S000001015|Protein required for meiosis
YOL119C	0.308717	GZF3	YOL119C|MCH4|S000005479|Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YJL166W	0.308375	GZF3	YJL166W|QCR8|S000003702|Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
YDR171W	0.30651	GZF3	YDR171W|HSP42|S000002578|Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YJL037W	0.305079	GZF3	YJL037W|IRC18|S000003574|Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YDL067C	0.304639	GZF3	YDL067C|COX9|S000002225|Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YJL217W	0.303857	GZF3	YJL217W||S000003753|Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YBR230C	0.303484	GZF3	YBR230C|OM14|S000000434|Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YGL033W	0.302945	GZF3	YGL033W|HOP2|S000003001|Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YJR137C	0.300201	GZF3	YJR137C|ECM17|S000003898|Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YKR095W	0.297916	GZF3	YKR095W|MLP1|S000001803|Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs
YML131W	0.295936	GZF3	YML131W||S000004600|Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YMR189W	0.294587	GZF3	YMR189W|GCV2|S000004801|P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
YEL070W	0.294365	GZF3	YEL070W|DSF1|S000000796|Deletion suppressor of mpt5 mutation
YLR247C	0.293304	GZF3	YLR247C|IRC20|S000004237|Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YOR098C	0.291141	GZF3	YOR098C|NUP1|S000005624|Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate
YFL036W	0.288818	GZF3	YFL036W|RPO41|S000001858|Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YNL183C	0.288134	GZF3	YNL183C|NPR1|S000005127|Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation
YER111C	0.285322	GZF3	YER111C|SWI4|S000000913|DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YNL017C	0.285054	GZF3	YNL017C||S000004962|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2
YOR192C	0.284649	GZF3	YOR192C|THI72|S000005718|Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YOR192C-C	0.284265	GZF3	YOR192C-C||S000028857|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YHR015W	0.281642	GZF3	YHR015W|MIP6|S000001057|Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YCL001W-B	0.280129	GZF3	YCL001W-B||S000007596|Putative protein of unknown function; identified by homology
YDR476C	0.279674	GZF3	YDR476C||S000002884|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YBR082C	0.273976	GZF3	YBR082C|UBC4|S000000286|Ubiquitin-conjugating enzyme (E2), mediates degradation of short-lived and abnormal proteins; interacts with E3-CaM in ubiquitinating calmodulin; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response
YDL012C	0.273863	GZF3	YDL012C||S000002170|Plasma membrane protein of unknown function; YDL012C is not an essential gene
YDL042C	0.272895	GZF3	YDL042C|SIR2|S000002200|Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication
YOR316C	0.272675	GZF3	YOR316C|COT1|S000005843|Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium
YBL099W	0.271954	GZF3	YBL099W|ATP1|S000000195|Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YGR254W	0.271817	GZF3	YGR254W|ENO1|S000003486|Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose
YFR045W	0.271732	GZF3	YFR045W||S000001941|Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
YHR102W	0.271207	GZF3	YHR102W|KIC1|S000001144|Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body
YDL227C	0.27109	GZF3	YDL227C|HO|S000002386|Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
YBR169C	0.270941	GZF3	YBR169C|SSE2|S000000373|Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p
YGL166W	0.270681	GZF3	YGL166W|CUP2|S000003134|Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations
YMR297W	0.270318	GZF3	YMR297W|PRC1|S000004912|Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YNL095C	0.270286	GZF3	YNL095C||S000005039|Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene
YER190W	0.270101	GZF3	YER190W|YRF1-2|S000000992|Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation
YEL074W	0.267569	GZF3	YEL074W||S000000800|Hypothetical protein
YIL100W	0.265941	GZF3	YIL100W||S000001362|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YER121W	0.265275	GZF3	YER121W||S000000923|Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YPR020W	0.264991	GZF3	YPR020W|ATP20|S000006224|Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
YDR387C	0.26494	GZF3	YDR387C||S000002795|Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
YDR032C	0.264928	GZF3	YDR032C|PST2|S000002439|Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR243W	0.263805	GZF3	YGR243W|FMP43|S000003475|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL121C	0.262073	GZF3	YJL121C|RPE1|S000003657|D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YJL110C	0.261476	GZF3	YJL110C|GZF3|S000003646|GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p
YIL100C-A	0.260436	GZF3	YIL100C-A||S000028794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR208C	0.25979	GZF3	YBR208C|DUR1,2|S000000412|Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YJR038C	0.258805	GZF3	YJR038C||S000003799|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR230W	0.257709	GZF3	YGR230W|BNS1|S000003462|Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis
YNL037C	0.255595	GZF3	YNL037C|IDH1|S000004982|Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YER186C	0.253404	GZF3	YER186C||S000000988|Putative protein of unknown function
YHR218W	0.253044	GZF3	YHR218W||S000001261|Helicase-like protein encoded within the telomeric Y' element
YAL066W	0.252904	GZF3	YAL066W||S000000061|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL058C	0.251673	GZF3	YPL058C|PDR12|S000005979|Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YDL149W	0.250869	GZF3	YDL149W|ATG9|S000002308|Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes; forms a complex with Atg23p and Atg27p
YDL089W	0.25005	GZF3	YDL089W||S000002247|Protein of unknown function; interacts with meiotic division protein Csm1p; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery, potential Cdc28p substrate
YIL134C-A	0.24913	GZF3	YIL134C-A||S000028556|Putative protein of unknown function, identified by fungal homology and RT-PCR
YDR176W	0.247929	GZF3	YDR176W|NGG1|S000002583|Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
YBL042C	0.246795	GZF3	YBL042C|FUI1|S000000138|High affinity uridine permease, localized to the plasma membrane; not involved in uracil transport
YGR045C	0.246525	GZF3	YGR045C||S000003277|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJR004C	0.246005	GZF3	YJR004C|SAG1|S000003764|Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
YAL067W-A	0.245723	GZF3	YAL067W-A||S000028593|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YIL023C	0.243085	GZF3	YIL023C|YKE4|S000001285|Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family
YOR358W	0.24129	GZF3	YOR358W|HAP5|S000005885|Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
YBR054W	0.240026	GZF3	YBR054W|YRO2|S000000258|Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YPR013C	0.239331	GZF3	YPR013C||S000006217|Putative zinc finger protein; YPR013C is not an essential gene
YER185W	0.238922	GZF3	YER185W|PUG1|S000000987|Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions
YDR039C	0.238173	GZF3	YDR039C|ENA2|S000002446|P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux
YKL178C	0.238129	GZF3	YKL178C|STE3|S000001661|Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YHL024W	0.236361	GZF3	YHL024W|RIM4|S000001016|Putative RNA-binding protein required for the expression of early and middle sporulation genes
YNL160W	0.234287	GZF3	YNL160W|YGP1|S000005104|Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YJL119C	0.233864	GZF3	YJL119C||S000003655|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR040W	0.233101	GZF3	YBR040W|FIG1|S000000244|Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
YOL160W	0.229452	GZF3	YOL160W||S000005520|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR046C	0.227598	GZF3	YKR046C|PET10|S000001754|Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange
YKL098W	0.227565	GZF3	YKL098W|MTC2|S000001581|Putative protein of unknown function; YKL098W is synthetically sick with cdc13-1
YML058W	0.227151	GZF3	YML058W|SML1|S000004523|Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase
YMR017W	0.225691	GZF3	YMR017W|SPO20|S000004619|Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YNL285W	0.225526	GZF3	YNL285W||S000005229|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR188C	0.225054	GZF3	YMR188C|MRPS17|S000004800|Mitochondrial ribosomal protein of the small subunit
YFR007W	0.224158	GZF3	YFR007W|YFH7|S000001903|Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YIL108W	0.221881	GZF3	YIL108W||S000001370|Putative metalloprotease
YEL075C	0.221384	GZF3	YEL075C||S000000801|Putative protein of unknown function
YMR095C	0.220176	GZF3	YMR095C|SNO1|S000004701|Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
YBL054W	0.218664	GZF3	YBL054W||S000000150|Protein of unknown function involved in rRNA and ribosome biosynthesis
YHR112C	0.218581	GZF3	YHR112C||S000001154|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR152C	0.218098	GZF3	YLR152C||S000004142|Putative protein of unknown function; YLR152C is not an essential gene
YOR344C	0.217632	GZF3	YOR344C|TYE7|S000005871|Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YBL096C	0.217268	GZF3	YBL096C||S000000192|Non-essential protein of unknown function
YMR304W	0.216576	GZF3	YMR304W|UBP15|S000004920|Ubiquitin-specific protease that may play a role in ubiquitin precursor processing
YGL071W	0.216545	GZF3	YGL071W|AFT1|S000003039|Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability
YDL174C	0.215335	GZF3	YDL174C|DLD1|S000002333|D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YJR127C	0.21436	GZF3	YJR127C|RSF2|S000003888|Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions
YOR149C	0.213043	GZF3	YOR149C|SMP3|S000005675|Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
YBL095W	0.21159	GZF3	YBL095W||S000000191|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL055C	0.211279	GZF3	YBL055C||S000000151|3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases
YHR125W	0.210104	GZF3	YHR125W||S000001167|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR438W	0.20973	GZF3	YLR438W|CAR2|S000004430|L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YKL220C	0.208665	GZF3	YKL220C|FRE2|S000001703|Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
YDR380W	0.2085	GZF3	YDR380W|ARO10|S000002788|Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
YOR377W	0.208279	GZF3	YOR377W|ATF1|S000005904|Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation
YER158C	0.208029	GZF3	YER158C||S000000960|Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YPL233W	0.207658	GZF3	YPL233W|NSL1|S000006154|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YCR067C	0.206478	GZF3	YCR067C|SED4|S000000663|Integral endoplasmic reticulum membrane protein, functions as a positive regulator of Sar1p probably through inhibition of GTPase activation by Sec23p; binds Sec16p, participates in vesicle formation, similar to Sec12p
YOR235W	0.205721	GZF3	YOR235W|IRC13|S000005761|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YOR200W	0.205578	GZF3	YOR200W||S000005726|Hypothetical protein
YJR049C	0.204821	GZF3	YJR049C|UTR1|S000003810|ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p)
YIL097W	0.204591	GZF3	YIL097W|FYV10|S000001359|Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis
YFL019C	0.204358	GZF3	YFL019C||S000001875|Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YOR148C	0.200832	GZF3	YOR148C|SPP2|S000005674|Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction
YPR145C-A	0.20045	GZF3	YPR145C-A||S000113589|Putative protein of unknown function
YGR161C	0.20043	GZF3	YGR161C|RTS3|S000003393|Putative component of the protein phosphatase type 2A complex
YNL042W	0.199291	GZF3	YNL042W|BOP3|S000004987|Protein of unknown function, potential Cdc28p substrate; overproduction suppresses a pam1 slv3 double null mutation and confers resistance to methylmercury
YDL237W	0.198936	GZF3	YDL237W|LRC1|S000002396|Putative protein of unknown function; YDL237W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YEL073C	0.198148	GZF3	YEL073C||S000000799|Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline
YML076C	0.197562	GZF3	YML076C|WAR1|S000004541|Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
YNL006W	0.197557	GZF3	YNL006W|LST8|S000004951|Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat
YDR317W	0.197294	GZF3	YDR317W|HIM1|S000002725|Protein of unknown function involved in DNA repair
YFL012W	0.196743	GZF3	YFL012W||S000001882|Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
YBL100C	0.196337	GZF3	YBL100C||S000000196|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YER008C	0.195368	GZF3	YER008C|SEC3|S000000810|Non-essential subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion
YDR132C	0.193981	GZF3	YDR132C||S000002539|Putative protein of unknown function
YAL039C	0.193943	GZF3	YAL039C|CYC3|S000000037|Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YOL025W	0.193496	GZF3	YOL025W|LAG2|S000005385|Protein involved in determination of longevity; LAG2 gene is preferentially expressed in young cells; overexpression extends the mean and maximum life span of cells
YGR184C	0.192659	GZF3	YGR184C|UBR1|S000003416|Ubiquitin-protein ligase (E3) that interacts with Rad6p/Ubc2p to ubiquitinate substrates of the N-end rule pathway; binds to the Rpn2p, Rpt1p, and Rpt6p proteins of the 19S particle of the 26S proteasome
YJL038C	0.191538	GZF3	YJL038C|LOH1|S000003575|Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YNL009W	0.191487	GZF3	YNL009W|IDP3|S000004954|Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids
YPL150W	0.19006	GZF3	YPL150W||S000006071|Putative protein kinase of unknown cellular role
YDR421W	0.189421	GZF3	YDR421W|ARO80|S000002829|Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
YPR023C	0.187944	GZF3	YPR023C|EAF3|S000006227|Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YOR186W	0.186846	GZF3	YOR186W||S000005712|Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YNL180C	0.185421	GZF3	YNL180C|RHO5|S000005124|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YGR286C	0.18483	GZF3	YGR286C|BIO2|S000003518|Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YHR101C	0.184813	GZF3	YHR101C|BIG1|S000001143|Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan
YDR436W	0.184515	GZF3	YDR436W|PPZ2|S000002844|Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
YBR008C	0.183664	GZF3	YBR008C|FLR1|S000000212|Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs
YAL044W-A	0.183178	GZF3	YAL044W-A||S000007586|Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein
YPL076W	0.182613	GZF3	YPL076W|GPI2|S000005997|Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein
YOR053W	0.182553	GZF3	YOR053W||S000005579|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C
YPR120C	0.181751	GZF3	YPR120C|CLB5|S000006324|B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YER184C	0.181283	GZF3	YER184C||S000000986|Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source
YMR250W	0.181138	GZF3	YMR250W|GAD1|S000004862|Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YJR019C	0.180304	GZF3	YJR019C|TES1|S000003780|Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
YBR183W	0.178939	GZF3	YBR183W|YPC1|S000000387|Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance
YPR015C	0.178389	GZF3	YPR015C||S000006219|Putative protein of unknown function
YDL054C	0.177025	GZF3	YDL054C|MCH1|S000002212|Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YHR092C	0.176043	GZF3	YHR092C|HXT4|S000001134|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YHR050W	0.173489	GZF3	YHR050W|SMF2|S000001092|Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YDR293C	0.172561	GZF3	YDR293C|SSD1|S000002701|Protein with a role in maintenance of cellular integrity, interacts with components of the TOR pathway; ssd1 mutant of a clinical S. cerevisiae strain displays elevated virulence
YLR138W	0.171924	GZF3	YLR138W|NHA1|S000004128|Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH
YGR194C	0.171867	GZF3	YGR194C|XKS1|S000003426|Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains
YER163C	0.170956	GZF3	YER163C||S000000965|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDL106C	0.170695	GZF3	YDL106C|PHO2|S000002264|Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p
YGL196W	0.170551	GZF3	YGL196W|DSD1|S000003164|D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia; specifc for D-serine, unlike the bacterial enzyme which recognizes both D-serine and L-serine as substrates
YEL049W	0.170094	GZF3	YEL049W|PAU2|S000000775|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YHL044W	0.169996	GZF3	YHL044W||S000001036|Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern
YFR012W	0.169784	GZF3	YFR012W||S000001908|Putative protein of unknown function
YDR397C	0.167118	GZF3	YDR397C|NCB2|S000002805|Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
YLR437C-A	0.166945	GZF3	YLR437C-A||S000028684|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YNL328C	0.166818	GZF3	YNL328C|MDJ2|S000005272|Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
YJR039W	0.166501	GZF3	YJR039W||S000003800|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL123W	0.166448	GZF3	YDL123W|SNA4|S000002281|Protein of unknown function, localized to the vacuolar outer membrane
YBR228W	0.165616	GZF3	YBR228W|SLX1|S000000432|Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YDR281C	0.165547	GZF3	YDR281C|PHM6|S000002689|Protein of unknown function, expression is regulated by phosphate levels
YDL214C	0.164455	GZF3	YDL214C|PRR2|S000002373|Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YAR027W	0.16442	GZF3	YAR027W|UIP3|S000000075|Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family
YKL044W	0.164392	GZF3	YKL044W||S000001527|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR182C	0.164383	GZF3	YBR182C|SMP1|S000000386|Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors
YLR053C	0.163296	GZF3	YLR053C||S000004043|Putative protein of unknown function
YKL029C	0.163138	GZF3	YKL029C|MAE1|S000001512|Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids
YGL255W	0.162987	GZF3	YGL255W|ZRT1|S000003224|High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YLR205C	0.162785	GZF3	YLR205C|HMX1|S000004195|ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1
YGL205W	0.162292	GZF3	YGL205W|POX1|S000003173|Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix
YJR020W	0.162187	GZF3	YJR020W||S000003781|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL127C-B	0.16019	GZF3	YJL127C-B||S000028522|Putative protein of unknown function; identified based on homology to the filamentous fungus, Ashbya gossypii
YER035W	0.159617	GZF3	YER035W|EDC2|S000000837|RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p
YGR056W	0.15947	GZF3	YGR056W|RSC1|S000003288|Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
YLR151C	0.157974	GZF3	YLR151C|PCD1|S000004141|Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids
YOR150W	0.15705	GZF3	YOR150W|MRPL23|S000005676|Mitochondrial ribosomal protein of the large subunit
YBR103W	0.156593	GZF3	YBR103W|SIF2|S000000307|WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
YCL035C	0.154849	GZF3	YCL035C|GRX1|S000000540|Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage
YGR250C	0.154278	GZF3	YGR250C||S000003482|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR388C	0.154159	GZF3	YOR388C|FDH1|S000005915|NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YNL053W	0.153986	GZF3	YNL053W|MSG5|S000004998|Dual-specificity protein phosphatase required for maintenance of a low level of signaling through the cell integrity pathway; regulates and is regulated by Slt2p; dephosphorylates Fus3p; required for adaptive response to pheromone
YHR188C	0.15382	GZF3	YHR188C|GPI16|S000001231|Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog
YOL085W-A	0.15316	GZF3	YOL085W-A||S000028708|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YPL148C	0.152805	GZF3	YPL148C|PPT2|S000006069|Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
YOL117W	0.151406	GZF3	YOL117W|RRI2|S000005477|Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
YGL236C	0.151243	GZF3	YGL236C|MTO1|S000003205|Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants
YOR237W	0.149916	GZF3	YOR237W|HES1|S000005763|Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)
YPR106W	0.149812	GZF3	YPR106W|ISR1|S000006310|Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
YNR004W	0.149432	GZF3	YNR004W||S000005287|Putative protein of unknown function; haploid disruptant exhibits slow growth rate on glucose-minimal medium at 15 C
YOL164W-A	0.148517	GZF3	YOL164W-A||S000028580|Putative protein of unknown function; identified by fungal homology and RT-PCR
YNL179C	0.148402	GZF3	YNL179C||S000005123|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YBR226C	0.148367	GZF3	YBR226C||S000000430|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W
YBR230W-A	0.148196	GZF3	YBR230W-A||S000029722|Putative protein of unknown function
YMR063W	0.147528	GZF3	YMR063W|RIM9|S000004667|Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein
YHR049C-A	0.145846	GZF3	YHR049C-A||S000003532|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR262C	0.145721	GZF3	YBR262C|AIM5|S000000466|Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and reduced growth rate in minimal glycerol media
YDR058C	0.145591	GZF3	YDR058C|TGL2|S000002465|Protein with lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; role in yeast lipid degradation is unclear
YNL278W	0.145423	GZF3	YNL278W|CAF120|S000005222|Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YOL159C-A	0.145	GZF3	YOL159C-A||S000007627|Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YPL151C	0.144807	GZF3	YPL151C|PRP46|S000006072|Splicing factor that is found in the Cef1p subcomplex of the spliceosome
YBR179C	0.144547	GZF3	YBR179C|FZO1|S000000383|Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YAL001C	0.141515	GZF3	YAL001C|TFC3|S000000001|Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YDR217C	0.141502	GZF3	YDR217C|RAD9|S000002625|DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate
YML133C	0.140734	GZF3	YML133C||S000004602|Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
YNL019C	0.140719	GZF3	YNL019C||S000004964|Putative protein of unknown function
YDL041W	0.140397	GZF3	YDL041W||S000002199|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C
YNL298W	0.13947	GZF3	YNL298W|CLA4|S000005242|Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
YML132W	0.139031	GZF3	YML132W|COS3|S000004601|Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YKL109W	0.137904	GZF3	YKL109W|HAP4|S000001592|Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YOR389W	0.137842	GZF3	YOR389W||S000005916|Putative protein of unknown function; expression regulated by copper levels
YLR425W	0.137818	GZF3	YLR425W|TUS1|S000004417|Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YNL088W	0.137648	GZF3	YNL088W|TOP2|S000005032|Essential type II topoisomerase, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis
YJL210W	0.136936	GZF3	YJL210W|PEX2|S000003746|RING-finger peroxin, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
YLR366W	0.136064	GZF3	YLR366W||S000004358|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YNR019W	0.135292	GZF3	YNR019W|ARE2|S000005302|Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen
YKR096W	0.135289	GZF3	YKR096W||S000001804|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain
YPL114W	0.135	GZF3	YPL114W||S000006035|Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index
YEL069C	0.13372	GZF3	YEL069C|HXT13|S000000795|Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose
YBR136W	0.133161	GZF3	YBR136W|MEC1|S000000340|Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination
YOL001W	0.131266	GZF3	YOL001W|PHO80|S000005361|Cyclin, negatively regulates phosphate metabolism; Pho80p-Pho85p (cyclin-CDK complex) phosphorylates Pho4p and Swi5p; deletion of PHO80 leads to aminoglycoside supersensitivity; truncated form of PHO80 affects vacuole inheritance
YDL105W	0.130991	GZF3	YDL105W|NSE4|S000002263|Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex
YDL057W	0.130841	GZF3	YDL057W||S000002215|Putative protein of unknown function; YDL057W is not an essential gene
YBL029C-A	0.130422	GZF3	YBL029C-A||S000007591|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica
YKL146W	0.13033	GZF3	YKL146W|AVT3|S000001629|Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YFL020C	0.130304	GZF3	YFL020C|PAU5|S000001874|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YCL033C	0.1297	GZF3	YCL033C||S000000538|Putative protein-methionine-R-oxide reductase; involved in response to oxidative stress; similar to mouse Sepx1p and fly SelRp; YCL033C is not an essential gene
YDR090C	0.12923	GZF3	YDR090C||S000002497|Putative protein of unknown function
YJR050W	0.128634	GZF3	YJR050W|ISY1|S000003811|Component of the spliceosome complex involved in pre-mRNA splicing, auxiliary splicing factor that may modulate Syf1p activity and help optimize splicing; isy1 syf2 double mutation activates the spindle checkpoint, causing cell cycle arrest
YBR035C	0.128067	GZF3	YBR035C|PDX3|S000000239|Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YLR189C	0.127287	GZF3	YLR189C|ATG26|S000004179|UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
YOR011W-A	0.127143	GZF3	YOR011W-A||S000028581|Putative protein of unknown function
YAL049C	0.126881	GZF3	YAL049C|AIM2|S000000047|Cytoplasmic protein of unknown function, potential Hsp82p interactor; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YPL219W	0.126817	GZF3	YPL219W|PCL8|S000006140|Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation
YMR194C-B	0.126481	GZF3	YMR194C-B||S000028514|Putative protein of unknown function
YNR050C	0.125107	GZF3	YNR050C|LYS9|S000005333|Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YPR009W	0.124078	GZF3	YPR009W|SUT2|S000006213|Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
YJL120W	0.122301	GZF3	YJL120W||S000003656|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO
YPL216W	0.121461	GZF3	YPL216W||S000006137|Putative protein of unknown function; YPL216W is not an essential gene
YGL117W	0.121202	GZF3	YGL117W||S000003085|Putative protein of unknown function
YPL006W	0.121087	GZF3	YPL006W|NCR1|S000005927|Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YKL147C	0.120903	GZF3	YKL147C||S000001630|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YIL122W	0.120368	GZF3	YIL122W|POG1|S000001384|Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YBR062C	0.119681	GZF3	YBR062C||S000000266|Hypothetical protein
YFL007W	0.119673	GZF3	YFL007W|BLM10|S000001887|Proteosome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200
YKL161C	0.1192	GZF3	YKL161C||S000001644|Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YDL168W	0.119076	GZF3	YDL168W|SFA1|S000002327|Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p
YOL052C	0.118619	GZF3	YOL052C|SPE2|S000005412|S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YOR199W	0.118237	GZF3	YOR199W||S000005725|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR438W	0.118004	GZF3	YDR438W|THI74|S000002846|Mitochondrial transporter repressible by thiamine
YGL167C	0.117632	GZF3	YGL167C|PMR1|S000003135|High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease
YOL045W	0.117531	GZF3	YOL045W|PSK2|S000005405|One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)
YGL007W	0.117271	GZF3	YGL007W|BRP1|S000002975|Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1
YKR091W	0.116823	GZF3	YKR091W|SRL3|S000001799|Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate
YPL272C	0.115991	GZF3	YPL272C||S000006193|Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene
YER061C	0.114937	GZF3	YER061C|CEM1|S000000863|Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration
YDL128W	0.114474	GZF3	YDL128W|VCX1|S000002286|Vacuolar H+/Ca2+ exchanger involved in control of cytosolic Ca2+ concentration; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
YLR342W	0.113484	GZF3	YLR342W|FKS1|S000004334|Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
YOL154W	0.112939	GZF3	YOL154W|ZPS1|S000005514|Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YAL037W	0.112884	GZF3	YAL037W||S000000035|Putative protein of unknown function
YNR063W	0.112152	GZF3	YNR063W||S000005346|Putative zinc-cluster protein of unknown function
YLR248W	0.112001	GZF3	YLR248W|RCK2|S000004238|Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YJL112W	0.111891	GZF3	YJL112W|MDV1|S000003648|Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
YBR018C	0.111213	GZF3	YBR018C|GAL7|S000000222|Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism
YGR121C	0.11072	GZF3	YGR121C|MEP1|S000003353|Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YPL190C	0.110357	GZF3	YPL190C|NAB3|S000006111|Single stranded RNA binding protein; acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing; interacts with Nrd1p
YNL267W	0.109958	GZF3	YNL267W|PIK1|S000005211|Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton
YKL043W	0.109462	GZF3	YKL043W|PHD1|S000001526|Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate
YJR036C	0.109365	GZF3	YJR036C|HUL4|S000003797|Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability
YLR146W-A	0.109235	GZF3	YLR146W-A||S000113566|Putative protein of unknown function
YFL042C	0.109204	GZF3	YFL042C||S000001852|Putative protein of unknown function; YFL042C is not an essential gene
YBR180W	0.108946	GZF3	YBR180W|DTR1|S000000384|Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YLR260W	0.108879	GZF3	YLR260W|LCB5|S000004250|Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
YDL230W	0.108831	GZF3	YDL230W|PTP1|S000002389|Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria
YPL106C	0.108813	GZF3	YPL106C|SSE1|S000006027|ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YJL199C	0.108514	GZF3	YJL199C|MBB1|S000003735|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YER075C	0.108315	GZF3	YER075C|PTP3|S000000877|Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
YLR070C	0.108235	GZF3	YLR070C|XYL2|S000004060|Xylitol dehydrogenase, converts xylitol to D-xylulose in the endogenous xylose utilization pathway
YNL271C	0.108004	GZF3	YNL271C|BNI1|S000005215|Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1
YGR258C	0.107802	GZF3	YGR258C|RAD2|S000003490|Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YPL202C	0.107381	GZF3	YPL202C|AFT2|S000006123|Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p
YDL231C	0.10496	GZF3	YDL231C|BRE4|S000002390|Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
YKL066W	0.104183	GZF3	YKL066W||S000001549|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
YBL082C	0.103562	GZF3	YBL082C|ALG3|S000000178|Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
YPL077C	0.103294	GZF3	YPL077C||S000005998|Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene
YHL025W	0.103109	GZF3	YHL025W|SNF6|S000001017|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p
YPR149W	0.100912	GZF3	YPR149W|NCE102|S000006353|Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YFL013C	0.100344	GZF3	YFL013C|IES1|S000001881|Subunit of the INO80 chromatin remodeling complex
YNL187W	0.100338	GZF3	YNL187W||S000005131|Putative protein of unknown function; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; may interact with or be fuctionally redundant with Prp40p
YIL048W	0.0999668	GZF3	YIL048W|NEO1|S000001310|Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
YLL005C	0.0999279	GZF3	YLL005C|SPO75|S000003928|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YBR295W	0.0995729	GZF3	YBR295W|PCA1|S000000499|Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; S288C and most other lab strains contain a G970R mutation which eliminates normal cadmium transport function
YGR269W	0.0991365	GZF3	YGR269W||S000003501|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C
YLR365W	0.0988063	GZF3	YLR365W||S000004357|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YDR511W	0.0987049	GZF3	YDR511W|ACN9|S000002919|Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes
YOL116W	0.0981272	GZF3	YOL116W|MSN1|S000005476|Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus
YLL033W	0.0981206	GZF3	YLL033W|IRC19|S000003956|Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci
YFL012W-A	0.0974283	GZF3	YFL012W-A||S000002964|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C
YLR203C	0.0969014	GZF3	YLR203C|MSS51|S000004193|Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein
YGR046W	0.0968041	GZF3	YGR046W|TAM41|S000003278|Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud
YDR441C	0.096323	GZF3	YDR441C|APT2|S000002849|Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YJR037W	0.0961928	GZF3	YJR037W||S000003798|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; YJR037W is not an essential gene.
YIR035C	0.0961824	GZF3	YIR035C||S000001474|Putative cytoplasmic protein of unknown function
YHR079C	0.0953814	GZF3	YHR079C|IRE1|S000001121|Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress
YMR084W	0.0950294	GZF3	YMR084W||S000004689|Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains
YML070W	0.0949342	GZF3	YML070W|DAK1|S000004535|Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YGR039W	0.0942273	GZF3	YGR039W||S000003271|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YGL256W	0.0936799	GZF3	YGL256W|ADH4|S000003225|Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YGL056C	0.0936429	GZF3	YGL056C|SDS23|S000003024|One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation
YDR358W	0.0935896	GZF3	YDR358W|GGA1|S000002766|Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi
YMR075W	0.0931959	GZF3	YMR075W|RCO1|S000004680|Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
YER053C	0.0930283	GZF3	YER053C|PIC2|S000000855|Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YHR177W	0.0926397	GZF3	YHR177W||S000001220|Putative protein of unknown function
YDR096W	0.0924033	GZF3	YDR096W|GIS1|S000002503|JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YJR160C	0.0923478	GZF3	YJR160C|MPH3|S000003921|Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YIL088C	0.0921715	GZF3	YIL088C|AVT7|S000001350|Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YHR155W	0.0917393	GZF3	YHR155W|YSP1|S000001198|Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone
YIL089W	0.0911844	GZF3	YIL089W||S000001351|Putative protein of unknown function
YIL135C	0.0904319	GZF3	YIL135C|VHS2|S000001397|Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
YHR082C	0.0902055	GZF3	YHR082C|KSP1|S000001124|Nonessential putative serine/threonine protein kinase of unknown cellular role; overproduction causes allele-specific suppression of the prp20-10 mutation
YIL046W-A	0.0898838	GZF3	YIL046W-A||S000028836|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YBR240C	0.0893325	GZF3	YBR240C|THI2|S000000444|Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
YOL026C	0.0892702	GZF3	YOL026C|MIM1|S000005386|Mitochondrial outer membrane protein, required for assembly of the translocase of the outer membrane (TOM) complex and thereby for mitochondrial protein import; N terminus is exposed to the cytosol: transmembrane segment is highly conserved
YDR024W	0.0881431	GZF3	YDR024W|FYV1|S000002431|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin
YLR393W	0.0879777	GZF3	YLR393W|ATP10|S000004385|Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YGR044C	0.0878245	GZF3	YGR044C|RME1|S000003276|Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-a2 regulator; mediates cell type control of sporulation
YER060W-A	0.0874778	GZF3	YER060W-A|FCY22|S000002958|Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YLL013C	0.0864452	GZF3	YLL013C|PUF3|S000003936|Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YIR005W	0.0860605	GZF3	YIR005W|IST3|S000001444|Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing
YER145C	0.084864	GZF3	YER145C|FTR1|S000000947|High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron
YDR220C	0.0845371	GZF3	YDR220C||S000002628|Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YJL149W	0.0842051	GZF3	YJL149W|DAS1|S000003685|Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; null mutant suppresses dst1delta sensitivity for 6-azauracil
YJR005W	0.0839016	GZF3	YJR005W|APL1|S000003765|Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex
YBR235W	0.083893	GZF3	YBR235W||S000000439|Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene
YJL027C	0.0837038	GZF3	YJL027C||S000003564|Putative protein of unknown function
YFL039C	0.0836891	GZF3	YFL039C|ACT1|S000001855|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YHL046C	0.0832809	GZF3	YHL046C|PAU13|S000001038|Putative protein of unknown function; not an essential gene
YOR365C	0.0817899	GZF3	YOR365C||S000005892|Putative protein of unknown function; YOR365C is not an essential protein
YOL053W	0.08175	GZF3	YOL053W|AIM39|S000005414|Putative protein of unknown function; YOL053W is not an essential gene; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YNR059W	0.0815811	GZF3	YNR059W|MNT4|S000005342|Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation
YPL099C	0.0815354	GZF3	YPL099C|AIM43|S000006020|Protein of unknown function;non-tagged protein detected in purified mitochondria in high-throughput studies; null mutant displays increased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YER080W	0.0814561	GZF3	YER080W|AIM9|S000000882|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YER060W	0.0809307	GZF3	YER060W|FCY21|S000000862|Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
YKL087C	0.0802606	GZF3	YKL087C|CYT2|S000001570|Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
YGR028W	0.0798492	GZF3	YGR028W|MSP1|S000003260|Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase
YPL067C	0.0789909	GZF3	YPL067C||S000005988|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene
YHL019W-A	0.0788186	GZF3	YHL019W-A||S000028772|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C
YHL037C	0.0786753	GZF3	YHL037C||S000001029|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR156C	0.0786547	GZF3	YHR156C|LIN1|S000001199|Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
YDL176W	0.0779299	GZF3	YDL176W||S000002335|Putative protein of unknown function; YDL176W is not an essential gene
YER017C	0.0775826	GZF3	YER017C|AFG3|S000000819|Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YLR095C	0.0767823	GZF3	YLR095C|IOC2|S000004085|Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif
YGL173C	0.0757642	GZF3	YGL173C|KEM1|S000003141|Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance
YLR035C	0.0757095	GZF3	YLR035C|MLH2|S000004025|Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p
YNL124W	0.0755046	GZF3	YNL124W|NAF1|S000005068|Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteins
YPR070W	0.0754602	GZF3	YPR070W|MED1|S000006274|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YPR024W	0.0753949	GZF3	YPR024W|YME1|S000006228|Subunit, with Mgr1p, of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover
YPL095C	0.0746511	GZF3	YPL095C|EEB1|S000006016|Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification
YOL126C	0.0743236	GZF3	YOL126C|MDH2|S000005486|Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1
YLR281C	0.0741943	GZF3	YLR281C||S000004271|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
YER084W-A	0.0738879	GZF3	YER084W-A||S000028752|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR010C	0.0734587	GZF3	YOR010C|TIR2|S000005536|Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
YDR485C	0.0733324	GZF3	YDR485C|VPS72|S000002893|Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YDR442W	0.0731312	GZF3	YDR442W||S000002850|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL102W	0.0727215	GZF3	YBL102W|SFT2|S000000198|Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YGL203C	0.072687	GZF3	YGL203C|KEX1|S000003171|Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
YDR229W	0.0724593	GZF3	YDR229W|IVY1|S000002637|Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase
YFL050C	0.071968	GZF3	YFL050C|ALR2|S000001844|Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition
YHR028W-A	0.0718357	GZF3	YHR028W-A||S000028776|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR335W	0.0716833	GZF3	YDR335W|MSN5|S000002743|Karyopherin involved in nuclear import and export; shown to be responsible for nuclear import of replication protein A and for export of several proteins including Swi6p, Far1p, and Pho4p; cargo dissociation involves binding to RanGTP
YHL026C	0.0714696	GZF3	YHL026C||S000001018|Putative protein of unknown function; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YGL134W	0.0714436	GZF3	YGL134W|PCL10|S000003102|Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate
YNL173C	0.0711729	GZF3	YNL173C|MDG1|S000005117|Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations
YDR532C	0.071154	GZF3	YDR532C||S000002940|Protein of unknown function that localizes to the nuclear side of the spindle pole body and along short spindles; deletion mutants have short telomeres; forms a complex with Spc105p
YPR065W	0.0709446	GZF3	YPR065W|ROX1|S000006269|Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YGR257C	0.0709396	GZF3	YGR257C|MTM1|S000003489|Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor
YGL163C	0.0695956	GZF3	YGL163C|RAD54|S000003131|DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YDR388W	0.0695455	GZF3	YDR388W|RVS167|S000002796|Actin-associated protein, subunit of a complex (Rvs161p-Rvs167p) involved in regulation of actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; homolog of mammalian amphiphysin
YAL046C	0.0691214	GZF3	YAL046C|AIM1|S000000044|Putative protein of unknown function; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YML122C	0.0688156	GZF3	YML122C||S000004591|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR233C	0.0676039	GZF3	YGR233C|PHO81|S000003465|Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p
YLR280C	0.0673744	GZF3	YLR280C||S000004270|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR120C	0.0667607	GZF3	YMR120C|ADE17|S000004727|Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine
YNL007C	0.0667256	GZF3	YNL007C|SIS1|S000004952|Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins
YMR195W	0.0665709	GZF3	YMR195W|ICY1|S000004808|Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YPL191C	0.0662979	GZF3	YPL191C||S000006112|Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR351C	0.0658569	GZF3	YOR351C|MEK1|S000005878|Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids
YPL046C	0.064593	GZF3	YPL046C|ELC1|S000005967|Elongin C, forms heterodimer with Ela1p that participates in transcription elongation; required for ubiquitin-dependent degradation of the RNA Polymerase II subunit RPO21; expression dramatically upregulated during sporulation
YIL109C	0.064416	GZF3	YIL109C|SEC24|S000001371|Component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat; involved in ER to Golgi transport, cargo selection and autophagy; required for the binding of the Sec13 complex to ER membranes; homologous to Lst1p and Lss1p
YLR144C	0.0642976	GZF3	YLR144C|ACF2|S000004134|Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly
YKR055W	0.0635299	GZF3	YKR055W|RHO4|S000001763|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity
YDL190C	0.0635036	GZF3	YDL190C|UFD2|S000002349|Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3
YOR236W	0.0634063	GZF3	YOR236W|DFR1|S000005762|Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
YDR104C	0.062671	GZF3	YDR104C|SPO71|S000002511|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YBR102C	0.0622126	GZF3	YBR102C|EXO84|S000000306|Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis
YJL174W	0.0617805	GZF3	YJL174W|KRE9|S000003710|Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
YER158W-A	0.0616304	GZF3	YER158W-A||S000028624|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGL064C	0.0611905	GZF3	YGL064C|MRH4|S000003032|Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function
YFL041W-A	0.0607077	GZF3	YFL041W-A||S000028547|Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL162C	0.0601774	GZF3	YDL162C||S000002321|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly
YHR113W	0.0594374	GZF3	YHR113W||S000001155|Cytoplasmic aspartyl aminopeptidase; cleaves unblocked N-terminal acidic amino acid residues from peptide substrates; forms a 12 subunit homo-oligomeric complex; M18 metalloprotease family member; may interact with ribosomes
YLR387C	0.0586563	GZF3	YLR387C|REH1|S000004379|Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains
YKL039W	0.0585671	GZF3	YKL039W|PTM1|S000001522|Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p
YDR440W	0.0583949	GZF3	YDR440W|DOT1|S000002848|Nucleosomal histone H3-Lys79 methylase, associates with transcriptionally active genes, functions in gene silencing at telomeres, most likely by directly modulating chromatin structure and Sir protein localization
YGL089C	0.0573485	GZF3	YGL089C|MF(ALPHA)2|S000003057|Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YOR366W	0.0573138	GZF3	YOR366W||S000005893|Hypothetical protein
YNR055C	0.057194	GZF3	YNR055C|HOL1|S000005338|Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake
YOR049C	0.0570907	GZF3	YOR049C|RSB1|S000005575|Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YKR018C	0.0570681	GZF3	YKR018C||S000001726|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YMR156C	0.0566259	GZF3	YMR156C|TPP1|S000004765|DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily
YCR097W-A	0.0566233	GZF3	YCR097W-A||S000007632|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein
YHL012W	0.0566181	GZF3	YHL012W||S000001004|Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase
YNL336W	0.0564186	GZF3	YNL336W|COS1|S000005280|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YHR028C	0.0562469	GZF3	YHR028C|DAP2|S000001070|Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p
YIL117C	0.0553133	GZF3	YIL117C|PRM5|S000001379|Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling
YPL061W	0.0552491	GZF3	YPL061W|ALD6|S000005982|Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YPL080C	0.0546515	GZF3	YPL080C||S000006001|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL167C	0.0546285	GZF3	YNL167C|SKO1|S000005111|Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, forms a complex with Tup1p and Ssn6p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses
YGR101W	0.0537662	GZF3	YGR101W|PCP1|S000003333|Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases
YMR275C	0.0537543	GZF3	YMR275C|BUL1|S000004888|Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases
YNL161W	0.0530645	GZF3	YNL161W|CBK1|S000005105|Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation
YPL257W	0.053029	GZF3	YPL257W||S000006178|Putative protein of unknown function;; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene
YIL022W	0.0528721	GZF3	YIL022W|TIM44|S000001284|Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membrane
YJL151C	0.0527633	GZF3	YJL151C|SNA3|S000003687|Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting
YLR436C	0.0525409	GZF3	YLR436C|ECM30|S000004428|Non-essential protein of unknown function
YHL045W	0.0524854	GZF3	YHL045W||S000001037|Putative protein of unknown function; not an essential gene
YDR136C	0.0523949	GZF3	YDR136C|VPS61|S000002543|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect
YMR018W	0.0517452	GZF3	YMR018W||S000004620|Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene
YDR160W	0.0514281	GZF3	YDR160W|SSY1|S000002567|Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YBL093C	0.0513365	GZF3	YBL093C|ROX3|S000000189|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
YER188W	0.051219	GZF3	YER188W||S000000990|Hypothetical protein
YKL139W	0.0511697	GZF3	YKL139W|CTK1|S000001622|Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates the C-terminal repeated domain of the RNA polymerase II large subunit (Rpo21p) to affect both transcription and pre-mRNA 3' end processing
YLR289W	0.0503674	GZF3	YLR289W|GUF1|S000004280|Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegans
YPL071C	0.0503602	GZF3	YPL071C||S000005992|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YKR054C	0.0501181	GZF3	YKR054C|DYN1|S000001762|Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p
YDL216C	0.0500724	GZF3	YDL216C|RRI1|S000002375|Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling
YBR060C	0.0500486	GZF3	YBR060C|ORC2|S000000264|Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
YCR018C-A	0.0498091	GZF3	YCR018C-A||S000007230|Putative protein of unknown function; encoded opposite a Ty1 LTR
YBL022C	0.0496119	GZF3	YBL022C|PIM1|S000000118|ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
YPR064W	0.0491602	GZF3	YPR064W||S000006268|Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOR183W	0.0486074	GZF3	YOR183W|FYV12|S000005709|Protein of unknown function, required for survival upon exposure to K1 killer toxin
YLR040C	0.0485553	GZF3	YLR040C||S000004030|Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential
YPL174C	0.0485485	GZF3	YPL174C|NIP100|S000006095|Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
YER125W	0.048332	GZF3	YER125W|RSP5|S000000927|Ubiquitin-protein ligase involved in ubiquitin-mediated protein degradation; functions in multivesicular body sorting, heat shock response and ubiquitylation of arrested RNAPII; contains a hect (homologous to E6-AP carboxyl terminus) domain
YKL071W	0.0477938	GZF3	YKL071W||S000001554|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YKL170W	0.047317	GZF3	YKL170W|MRPL38|S000001653|Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels
YEL050C	0.0467891	GZF3	YEL050C|RML2|S000000776|Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YER164W	0.0457087	GZF3	YER164W|CHD1|S000000966|Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes
YLR126C	0.0456284	GZF3	YLR126C||S000004116|Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein
YDL146W	0.0455205	GZF3	YDL146W|LDB17|S000002305|Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; null mutant shows a reduced affinity for the alcian blue dye suggesting a decreased net negative charge of the cell surface
YFR016C	0.0443244	GZF3	YFR016C||S000001912|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene
YJR130C	0.044032	GZF3	YJR130C|STR2|S000003891|Cystathionine gamma-synthase, converts cysteine into cystathionine
YKL160W	0.0433888	GZF3	YKL160W|ELF1|S000001643|Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression
YDL066W	0.0431814	GZF3	YDL066W|IDP1|S000002224|Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YGL018C	0.0428447	GZF3	YGL018C|JAC1|S000002986|Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
YNL054W	0.0422739	GZF3	YNL054W|VAC7|S000004999|Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock
YBL050W	0.0421245	GZF3	YBL050W|SEC17|S000000146|Peripheral membrane protein required for vesicular transport between ER and Golgi and for the 'priming' step in homotypic vacuole fusion, part of the cis-SNARE complex; has similarity to alpha-SNAP
YGL041C	0.041888	GZF3	YGL041C||S000003009|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR085C-A	0.0405038	GZF3	YBR085C-A||S000007522|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YMR134W	0.0401374	GZF3	YMR134W|ERG29|S000004741|Protein that binds to and regulates Erg25p; localized to the ER; null mutant is viable in a respiratory defective background; synthetic lethal with mmt1 and mmt2 mutations; highly conserved in ascomycetes
YOL164W	0.0401211	GZF3	YOL164W|BDS1|S000005524|Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources
YPL135C-A	0.0395315	GZF3	YPL135C-A||S000028720|Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGL041C-B	0.0389525	GZF3	YGL041C-B||S000028548|Putative protein of unknown function; identified by fungal homology and RT-PCR
YPR138C	0.0382017	GZF3	YPR138C|MEP3|S000006342|Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease
YKR071C	0.0376924	GZF3	YKR071C|DRE2|S000001779|Protein of unknown function required for sister chromatid cohesion; mutation displays synthetic lethal interaction with the pol3-13 allele of CDC2
YDR097C	0.0376242	GZF3	YDR097C|MSH6|S000002504|Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p
YDR135C	0.0370548	GZF3	YDR135C|YCF1|S000002542|Vacuolar glutathione S-conjugate transporter of the ATP-binding cassette family, has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin; similar to human cystic fibrosis protein CFTR
YBR234C	0.0369645	GZF3	YBR234C|ARC40|S000000438|Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YHR118C	0.0366721	GZF3	YHR118C|ORC6|S000001160|Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p
YNL339C	0.0366543	GZF3	YNL339C|YRF1-6|S000005283|Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YDR294C	0.0357423	GZF3	YDR294C|DPL1|S000002702|Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
YNL164C	0.0357111	GZF3	YNL164C|IBD2|S000005108|Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p
YLR041W	0.0347512	GZF3	YLR041W||S000004031|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C
YMR193W	0.0344396	GZF3	YMR193W|MRPL24|S000004806|Mitochondrial ribosomal protein of the large subunit
YGL150C	0.0337634	GZF3	YGL150C|INO80|S000003118|ATPase that forms a large complex, containing actin and several actin-related proteins, that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; shows similarity to the Snf2p family of ATPases
YMR007W	0.0333955	GZF3	YMR007W||S000004609|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL063W	0.0329694	GZF3	YGL063W|PUS2|S000003031|Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification
YBL103C	0.0319102	GZF3	YBL103C|RTG3|S000000199|Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways
YCR001W	0.0316654	GZF3	YCR001W||S000000594|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
YAL021C	0.0312269	GZF3	YAL021C|CCR4|S000000019|Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
YPL154C	0.0309933	GZF3	YPL154C|PEP4|S000006075|Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates
YBL081W	0.0309846	GZF3	YBL081W||S000000177|Non-essential protein of unknown function
YMR074C	0.030679	GZF3	YMR074C||S000004678|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR074C is not an essential gene
YKL079W	0.029975	GZF3	YKL079W|SMY1|S000001562|Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins
YLR255C	0.0296097	GZF3	YLR255C||S000004245|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR114W	0.0283796	GZF3	YHR114W|BZZ1|S000001156|SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins
YJL034W	0.0274993	GZF3	YJL034W|KAR2|S000003571|ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
YMR276W	0.0272662	GZF3	YMR276W|DSK2|S000004889|Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome
YER099C	0.0267627	GZF3	YER099C|PRS2|S000000901|5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YGL041W-A	0.0264917	GZF3	YGL041W-A||S000028826|Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry
YOL058W	0.0264672	GZF3	YOL058W|ARG1|S000005419|Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate
YOL062C	0.0264591	GZF3	YOL062C|APM4|S000005423|Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
YKL002W	0.0256348	GZF3	YKL002W|DID4|S000001485|Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
YNL004W	0.0255113	GZF3	YNL004W|HRB1|S000004949|Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p
YBL051C	0.0252494	GZF3	YBL051C|PIN4|S000000147|Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage
YKL101W	0.0251007	GZF3	YKL101W|HSL1|S000001584|Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YHR119W	0.0247149	GZF3	YHR119W|SET1|S000001161|Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain
YGL162W	0.0238747	GZF3	YGL162W|SUT1|S000003130|Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression
YJL186W	0.0237775	GZF3	YJL186W|MNN5|S000003722|Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YCR081W	0.0235161	GZF3	YCR081W|SRB8|S000000677|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
YBR220C	0.0233917	GZF3	YBR220C||S000000424|Putative protein of unknown function; YBR220C is not an essential gene
YBL025W	0.0225995	GZF3	YBL025W|RRN10|S000000121|Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
YNL337W	0.0216182	GZF3	YNL337W||S000005281|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR285W	0.0215154	GZF3	YDR285W|ZIP1|S000002693|Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate
YBR016W	0.0205007	GZF3	YBR016W||S000000220|Plasma membrane protein of unknown function; has similarity to hydrophilins, which are hydrophilic, glycine-rich proteins involved in the adaptive response to hyperosmotic conditions
YDR168W	0.0203823	GZF3	YDR168W|CDC37|S000002575|Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding
YMR316W	0.0194564	GZF3	YMR316W|DIA1|S000004935|Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YFR057W	0.0192468	GZF3	YFR057W||S000001953|Putative protein of unknown function
YLL032C	0.0191299	GZF3	YLL032C||S000003955|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
YLR204W	0.0189072	GZF3	YLR204W|QRI5|S000004194|Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
YER010C	0.0185382	GZF3	YER010C||S000000812|Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YKL003C	0.018086	GZF3	YKL003C|MRP17|S000001486|Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator
YDR523C	0.0179924	GZF3	YDR523C|SPS1|S000002931|Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
YER071C	0.0178346	GZF3	YER071C||S000000873|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR052C	0.0177775	GZF3	YOR052C||S000005578|Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid
YNL306W	0.0175247	GZF3	YNL306W|MRPS18|S000005250|Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins
YJL176C	0.0175001	GZF3	YJL176C|SWI3|S000003712|Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2
YBR107C	0.0163168	GZF3	YBR107C|IML3|S000000311|Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p
YGR260W	0.0160186	GZF3	YGR260W|TNA1|S000003492|High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YJL214W	0.0158912	GZF3	YJL214W|HXT8|S000003750|Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YDR068W	0.015526	GZF3	YDR068W|DOS2|S000002475|Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR150C	0.0154022	GZF3	YGR150C|DMR1|S000003382|Protein of unknown function, contains PPR motifs; mutant has growth defects on both non-fermentable carbon sources and rich medium; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL098C	0.015063	GZF3	YIL098C|FMC1|S000001360|Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p
YJL146W	0.0146758	GZF3	YJL146W|IDS2|S000003682|Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation
YPL070W	0.0143412	GZF3	YPL070W|MUK1|S000005991|Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation
YPL115C	0.0138153	GZF3	YPL115C|BEM3|S000006036|Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
YLR392C	0.0136684	GZF3	YLR392C||S000004384|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR392C is not an essential gene
YPL125W	0.0131527	GZF3	YPL125W|KAP120|S000006046|Karyopherin with a role in the assembly or export of 60S ribosomal subunits
YNL219C	0.0120236	GZF3	YNL219C|ALG9|S000005163|Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
YDR219C	0.0119689	GZF3	YDR219C|MFB1|S000002627|Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding
YIR006C	0.011895	GZF3	YIR006C|PAN1|S000001445|Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease
YNR048W	0.0116914	GZF3	YNR048W||S000005331|Protein proposed to interact with phospholipid translocases, shares similarity to Cdc50p
YNR060W	0.0114081	GZF3	YNR060W|FRE4|S000005343|Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YDR221W	0.0108307	GZF3	YDR221W|GTB1|S000002629|Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER
YOR261C	0.01062	GZF3	YOR261C|RPN8|S000005787|Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p
YJL118W	0.010452	GZF3	YJL118W||S000003654|Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein
YER133W-A	0.00930473	GZF3	YER133W-A||S000028756|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YBR114W	0.00929931	GZF3	YBR114W|RAD16|S000000318|Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex
YLR360W	0.00915177	GZF3	YLR360W|VPS38|S000004352|Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity
YGL118C	0.00905834	GZF3	YGL118C||S000003086|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR053C	0.00884062	GZF3	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YOR279C	0.00799149	GZF3	YOR279C|RFM1|S000005805|DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance
YFL049W	0.00778448	GZF3	YFL049W|SWP82|S000001845|Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p
YER042W	0.00720012	GZF3	YER042W|MXR1|S000000844|Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan
YDR141C	0.0070351	GZF3	YDR141C|DOP1|S000002548|Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR262W	0.00634901	GZF3	YOR262W||S000005788|Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B
YDL007C-A	0.00620643	GZF3	YDL007C-A||S000113557|Putative protein of unknown function
YJL175W	0.00569946	GZF3	YJL175W||S000003711|Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
YJL098W	0.00566343	GZF3	YJL098W|SAP185|S000003634|Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p
YDR006C	0.00562116	GZF3	YDR006C|SOK1|S000002413|Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13
YCL032W	0.00503427	GZF3	YCL032W|STE50|S000000537|Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
YCR032W	0.00496253	GZF3	YCR032W|BPH1|S000000628|PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting
YPL173W	0.0047781	GZF3	YPL173W|MRPL40|S000006094|Mitochondrial ribosomal protein of the large subunit
YIL026C	0.00444117	GZF3	YIL026C|IRR1|S000001288|Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
YBR024W	0.00434112	GZF3	YBR024W|SCO2|S000000228|Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YKR076W	0.00402785	GZF3	YKR076W|ECM4|S000001784|Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YGR224W	0.00372331	GZF3	YGR224W|AZR1|S000003456|Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole
YDL045C	0.00317428	GZF3	YDL045C|FAD1|S000002203|Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
YDL025C	0.00288995	GZF3	YDL025C||S000002183|Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene
YMR244C-A	0.00288007	GZF3	YMR244C-A||S000004857|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene
YHR157W	0.00270737	GZF3	YHR157W|REC104|S000001200|Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination
YGR154C	0.00249138	GZF3	YGR154C|GTO1|S000003386|Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization
YNL286W	0.00200119	GZF3	YNL286W|CUS2|S000005230|Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)
YBR301W	0.0016985	GZF3	YBR301W|DAN3|S000000505|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YIL095W	0.00161583	GZF3	YIL095W|PRK1|S000001357|Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton through the phosphorylation of the Pan1p-Sla1p-End3p protein complex
YER100W	0.00146142	GZF3	YER100W|UBC6|S000000902|Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway
YMR294W	0.00120943	GZF3	YMR294W|JNM1|S000004908|Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
YIL025C	0.000939087	GZF3	YIL025C||S000001287|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML130C	0.000822828	GZF3	YML130C|ERO1|S000004599|Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
YDR029W	0.000445095	GZF3	YDR029W||S000002436|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YBR059C	0.000215546	GZF3	YBR059C|AKL1|S000000263|Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization
