YFR055W	38.6425	CAT8	YFR055W|IRC7|S000001952|Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C	32.2756	CAT8	YFR056C||S000001951|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YLR154W-A	28.2942	CAT8	YLR154W-A||S000028675|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B	27.2186	CAT8	YLR154W-B||S000028563|Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154C	26.63	CAT8	YLR154C|RNH203|S000004144|Ribonuclease H2 subunit, required for RNase H2 activity
YNL178W	20.7941	CAT8	YNL178W|RPS3|S000005122|Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YLR154W-C	18.9504	CAT8	YLR154W-C|TAR1|S000028422|Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YDR098C	16.0304	CAT8	YDR098C|GRX3|S000002505|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YER131W	13.4417	CAT8	YER131W|RPS26B|S000000933|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YDR345C	11.096	CAT8	YDR345C|HXT3|S000002753|Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YOL086C	10.5275	CAT8	YOL086C|ADH1|S000005446|Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YPL250W-A	10.4631	CAT8	YPL250W-A||S000028589|Identified by fungal homology and RT-PCR
YDL047W	10.1926	CAT8	YDL047W|SIT4|S000002205|Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YFL022C	9.7332	CAT8	YFL022C|FRS2|S000001872|Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YFR054C	9.23763	CAT8	YFR054C||S000001950|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR226C	8.27912	CAT8	YOR226C|ISU2|S000005752|Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YGR251W	8.0245	CAT8	YGR251W||S000003483|Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YHR208W	7.78695	CAT8	YHR208W|BAT1|S000001251|Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YBL063W	7.77028	CAT8	YBL063W|KIP1|S000000159|Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YBR158W	7.69458	CAT8	YBR158W|AMN1|S000000362|Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YJL153C	7.60717	CAT8	YJL153C|INO1|S000003689|Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YDR344C	7.57463	CAT8	YDR344C||S000002752|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL055W	7.31669	CAT8	YGL055W|OLE1|S000003023|Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YER146W	7.08382	CAT8	YER146W|LSM5|S000000948|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YFL015C	7.05095	CAT8	YFL015C||S000001879|Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YFL015W-A	6.98055	CAT8	YFL015W-A||S000028765|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL124C	6.77732	CAT8	YOL124C|TRM11|S000005484|Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YGR138C	6.75572	CAT8	YGR138C|TPO2|S000003370|Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YMR290C	6.72493	CAT8	YMR290C|HAS1|S000004903|ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YNR001W-A	6.71834	CAT8	YNR001W-A||S000007625|Dubious open reading frame unlikely to encode a functional protein; identified by homology
YMR290W-A	6.57351	CAT8	YMR290W-A||S000004904|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YMR001C-A	6.4219	CAT8	YMR001C-A||S000028691|Putative protein of unknown function
YNR016C	6.35614	CAT8	YNR016C|ACC1|S000005299|Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YNL065W	6.34317	CAT8	YNL065W|AQR1|S000005009|Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YPL075W	6.31769	CAT8	YPL075W|GCR1|S000005996|Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YDR033W	6.17651	CAT8	YDR033W|MRH1|S000002440|Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YKL110C	6.13658	CAT8	YKL110C|KTI12|S000001593|Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YOR272W	6.04655	CAT8	YOR272W|YTM1|S000005798|Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YDR133C	5.79916	CAT8	YDR133C||S000002540|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YDL023C	5.68531	CAT8	YDL023C||S000002181|Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YAL038W	5.67001	CAT8	YAL038W|CDC19|S000000036|Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YOR376W-A	5.53389	CAT8	YOR376W-A||S000028586|Putative protein of unknown function; identified by fungal homology and RT-PCR
YLL045C	5.45368	CAT8	YLL045C|RPL8B|S000003968|Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YGR140W	5.41204	CAT8	YGR140W|CBF2|S000003372|Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YDR095C	5.38404	CAT8	YDR095C||S000002502|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL096W-A	5.37623	CAT8	YKL096W-A|CWP2|S000001956|Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YGR052W	5.36906	CAT8	YGR052W|FMP48|S000003284|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YJR094W-A	5.35441	CAT8	YJR094W-A|RPL43B|S000003855|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YIL118W	5.3057	CAT8	YIL118W|RHO3|S000001380|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YDL022C-A	5.25478	CAT8	YDL022C-A||S000028537|Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YIL009W	5.18663	CAT8	YIL009W|FAA3|S000001271|Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YOR271C	5.09063	CAT8	YOR271C|FSF1|S000005797|Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YDL007W	4.98746	CAT8	YDL007W|RPT2|S000002165|One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YKR041W	4.93652	CAT8	YKR041W||S000001749|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDR094W	4.90768	CAT8	YDR094W||S000002501|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YMR205C	4.84781	CAT8	YMR205C|PFK2|S000004818|Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YDL048C	4.83584	CAT8	YDL048C|STP4|S000002206|Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YKR038C	4.82661	CAT8	YKR038C|KAE1|S000001746|Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YMR011W	4.7925	CAT8	YMR011W|HXT2|S000004613|High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YDL022W	4.74405	CAT8	YDL022W|GPD1|S000002180|NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YKR075C	4.71021	CAT8	YKR075C||S000001783|Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDL241W	4.61216	CAT8	YDL241W||S000002400|Putative protein of unknown function; YDL241W is not an essential gene
YDR279W	4.58873	CAT8	YDR279W|RNH202|S000002687|Ribonuclease H2 subunit, required for RNase H2 activity
YOR375C	4.58764	CAT8	YOR375C|GDH1|S000005902|NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YOR063W	4.57991	CAT8	YOR063W|RPL3|S000005589|Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YGR050C	4.5637	CAT8	YGR050C||S000003282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL063C	4.479	CAT8	YKL063C||S000001546|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YER130C	4.45693	CAT8	YER130C||S000000932|Hypothetical protein
YIR021W	4.40213	CAT8	YIR021W|MRS1|S000001460|Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YOL085C	4.35134	CAT8	YOL085C||S000005445|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YHR128W	4.33225	CAT8	YHR128W|FUR1|S000001170|Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway
YGL031C	4.29178	CAT8	YGL031C|RPL24A|S000002999|Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YPR157W	4.25774	CAT8	YPR157W||S000006361|Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YHR094C	4.248	CAT8	YHR094C|HXT1|S000001136|Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YDL085C-A	4.20178	CAT8	YDL085C-A||S000007588|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR139W	4.12386	CAT8	YGR139W||S000003371|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL211C	4.11586	CAT8	YDL211C||S000002370|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YOL123W	4.08891	CAT8	YOL123W|HRP1|S000005483|Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YNL118C	4.02705	CAT8	YNL118C|DCP2|S000005062|Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family
YEL053W-A	4.01873	CAT8	YEL053W-A||S000028744|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YCR031C	4.0072	CAT8	YCR031C|RPS14A|S000000627|Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YIL009C-A	3.98469	CAT8	YIL009C-A|EST3|S000006432|Component of the telomerase holoenzyme, involved in telomere replication
YER012W	3.96291	CAT8	YER012W|PRE1|S000000814|Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YHR216W	3.89372	CAT8	YHR216W|IMD2|S000001259|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YIL148W	3.86271	CAT8	YIL148W|RPL40A|S000001410|Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YPL263C	3.84299	CAT8	YPL263C|KEL3|S000006184|Cytoplasmic protein of unknown function
YMR108W	3.83761	CAT8	YMR108W|ILV2|S000004714|Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YGL030W	3.81706	CAT8	YGL030W|RPL30|S000002998|Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YJL158C	3.8002	CAT8	YJL158C|CIS3|S000003694|Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YBR106W	3.7843	CAT8	YBR106W|PHO88|S000000310|Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YGL009C	3.73657	CAT8	YGL009C|LEU1|S000002977|Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YNR054C	3.73015	CAT8	YNR054C|ESF2|S000005337|Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YEL054C	3.69137	CAT8	YEL054C|RPL12A|S000000780|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YBL077W	3.67847	CAT8	YBL077W||S000000173|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YDL075W	3.64451	CAT8	YDL075W|RPL31A|S000002233|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YDR144C	3.63048	CAT8	YDR144C|MKC7|S000002551|GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YGR051C	3.60942	CAT8	YGR051C||S000003283|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YOR096W	3.53387	CAT8	YOR096W|RPS7A|S000005622|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YJL145W	3.51118	CAT8	YJL145W|SFH5|S000003681|Putative phosphatidylinositol transfer protein (PITP), exhibits phosphatidylinositol- but not phosphatidylcholine-transfer activity, localized to cytosol and microsomes, similar to Sec14p; may be PITP regulator rather than actual PITP
YPR074C	3.50146	CAT8	YPR074C|TKL1|S000006278|Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YDR146C	3.48347	CAT8	YDR146C|SWI5|S000002553|Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YLR325C	3.43117	CAT8	YLR325C|RPL38|S000004317|Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YFR025C	3.42086	CAT8	YFR025C|HIS2|S000001921|Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YMR123W	3.41204	CAT8	YMR123W|PKR1|S000004730|V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YLR355C	3.40949	CAT8	YLR355C|ILV5|S000004347|Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YJR016C	3.39828	CAT8	YJR016C|ILV3|S000003777|Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
YMR217W	3.36436	CAT8	YMR217W|GUA1|S000004830|GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YNL289W	3.34794	CAT8	YNL289W|PCL1|S000005233|Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YLR257W	3.34258	CAT8	YLR257W||S000004247|Putative protein of unknown function
YFL016C	3.33854	CAT8	YFL016C|MDJ1|S000001878|Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YGL097W	3.28746	CAT8	YGL097W|SRM1|S000003065|Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YPL062W	3.27157	CAT8	YPL062W||S000005983|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YLR328W	3.2651	CAT8	YLR328W|NMA1|S000004320|Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YMR102C	3.26154	CAT8	YMR102C||S000004708|Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YHR163W	3.25809	CAT8	YHR163W|SOL3|S000001206|6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p
YNL162W	3.25569	CAT8	YNL162W|RPL42A|S000005106|Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein
YGR060W	3.2288	CAT8	YGR060W|ERG25|S000003292|C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
YMR183C	3.22298	CAT8	YMR183C|SSO2|S000004795|Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YEL068C	3.21343	CAT8	YEL068C||S000000794|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL119C	3.21009	CAT8	YKL119C|VPH2|S000001602|Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER)
YDR385W	3.19431	CAT8	YDR385W|EFT2|S000002793|Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YDR044W	3.19196	CAT8	YDR044W|HEM13|S000002451|Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YJR145C	3.18141	CAT8	YJR145C|RPS4A|S000003906|Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YER055C	3.15952	CAT8	YER055C|HIS1|S000000857|ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YKL008C	3.15775	CAT8	YKL008C|LAC1|S000001491|Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YNL111C	3.14266	CAT8	YNL111C|CYB5|S000005055|Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YHR181W	3.13142	CAT8	YHR181W|SVP26|S000001224|Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YOL101C	3.1305	CAT8	YOL101C|IZH4|S000005461|Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YBR032W	3.11775	CAT8	YBR032W||S000000236|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YGR218W	3.10417	CAT8	YGR218W|CRM1|S000003450|Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
YLR344W	3.03628	CAT8	YLR344W|RPL26A|S000004336|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YOL038W	2.94209	CAT8	YOL038W|PRE6|S000005398|Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YGL202W	2.93376	CAT8	YGL202W|ARO8|S000003170|Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YPR043W	2.93163	CAT8	YPR043W|RPL43A|S000006247|Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YLR109W	2.93153	CAT8	YLR109W|AHP1|S000004099|Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YDR215C	2.91617	CAT8	YDR215C||S000002623|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein
YEL020C-B	2.89629	CAT8	YEL020C-B||S000028544|Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YPR102C	2.89361	CAT8	YPR102C|RPL11A|S000006306|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YKL218C	2.88211	CAT8	YKL218C|SRY1|S000001701|3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YOR293W	2.84684	CAT8	YOR293W|RPS10A|S000005819|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YLR312W-A	2.83124	CAT8	YLR312W-A|MRPL15|S000004304|Mitochondrial ribosomal protein of the large subunit
YDR037W	2.80197	CAT8	YDR037W|KRS1|S000002444|Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YGL120C	2.78769	CAT8	YGL120C|PRP43|S000003088|RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YPL197C	2.77914	CAT8	YPL197C||S000006118|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B
YER091C	2.74336	CAT8	YER091C|MET6|S000000893|Cobalamin-independent methionine synthase, involved in amino acid biosynthesis; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
YMR263W	2.71609	CAT8	YMR263W|SAP30|S000004876|Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
YMR012W	2.6982	CAT8	YMR012W|CLU1|S000004614|eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
YJR105W	2.68621	CAT8	YJR105W|ADO1|S000003866|Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YKL182W	2.68423	CAT8	YKL182W|FAS1|S000001665|Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YBL085W	2.65771	CAT8	YBL085W|BOI1|S000000181|Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YKL120W	2.64018	CAT8	YKL120W|OAC1|S000001603|Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YKL081W	2.62171	CAT8	YKL081W|TEF4|S000001564|Translation elongation factor EF-1 gamma
YML127W	2.6123	CAT8	YML127W|RSC9|S000004596|Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
YER177W	2.57584	CAT8	YER177W|BMH1|S000000979|14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YOR029W	2.57229	CAT8	YOR029W||S000005555|Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YBR182C-A	2.57044	CAT8	YBR182C-A||S000028603|Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLL008W	2.56361	CAT8	YLL008W|DRS1|S000003931|Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles
YBR257W	2.55438	CAT8	YBR257W|POP4|S000000461|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P
YDR047W	2.53144	CAT8	YDR047W|HEM12|S000002454|Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents
YLR249W	2.52627	CAT8	YLR249W|YEF3|S000004239|Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YNR017W	2.5238	CAT8	YNR017W|TIM23|S000005300|Essential protein of the mitochondrial inner membrane, component of the mitochondrial import system
YGL209W	2.51813	CAT8	YGL209W|MIG2|S000003177|Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YEL066W	2.50782	CAT8	YEL066W|HPA3|S000000792|D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YMR303C	2.5068	CAT8	YMR303C|ADH2|S000004918|Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YPR029C	2.4835	CAT8	YPR029C|APL4|S000006233|Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YOR320C	2.48281	CAT8	YOR320C|GNT1|S000005847|N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus
YMR106C	2.48141	CAT8	YMR106C|YKU80|S000004712|Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YGR108W	2.4805	CAT8	YGR108W|CLB1|S000003340|B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YPR063C	2.47881	CAT8	YPR063C||S000006267|ER-localized protein of unknown function
YLR212C	2.4608	CAT8	YLR212C|TUB4|S000004202|Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body
YDR101C	2.43179	CAT8	YDR101C|ARX1|S000002508|Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YBR206W	2.42404	CAT8	YBR206W||S000000410|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3
YJR047C	2.42286	CAT8	YJR047C|ANB1|S000003808|Translation initiation factor eIF-5A, promotes formation of the first peptide bond; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions
YER137C	2.40535	CAT8	YER137C||S000000939|Putative protein of unknown function
YGR264C	2.40053	CAT8	YGR264C|MES1|S000003496|Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YDR450W	2.40005	CAT8	YDR450W|RPS18A|S000002858|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YOR273C	2.39891	CAT8	YOR273C|TPO4|S000005799|Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily
YBL070C	2.38796	CAT8	YBL070C||S000000166|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCL018W	2.38318	CAT8	YCL018W|LEU2|S000000523|Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YLR132C	2.36177	CAT8	YLR132C||S000004122|Protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to mitochondria and nucleus; YLR132C is an essential gene
YDL134C	2.33461	CAT8	YDL134C|PPH21|S000002292|Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YGR265W	2.32428	CAT8	YGR265W||S000003497|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YBR210W	2.32424	CAT8	YBR210W|ERV15|S000000414|Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YOR269W	2.31681	CAT8	YOR269W|PAC1|S000005795|Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
YMR037C	2.30665	CAT8	YMR037C|MSN2|S000004640|Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YOR342C	2.30382	CAT8	YOR342C||S000005869|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YKL009W	2.29865	CAT8	YKL009W|MRT4|S000001492|Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus
YOR108W	2.29706	CAT8	YOR108W|LEU9|S000005634|Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YGR020C	2.27881	CAT8	YGR020C|VMA7|S000003252|Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YGL158W	2.2725	CAT8	YGL158W|RCK1|S000003126|Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YKL219W	2.24055	CAT8	YKL219W|COS9|S000001702|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YLR262C	2.2351	CAT8	YLR262C|YPT6|S000004252|GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6
YHR007C	2.23179	CAT8	YHR007C|ERG11|S000001049|Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YOR028C	2.2169	CAT8	YOR028C|CIN5|S000005554|Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YHR180W-A	2.21276	CAT8	YHR180W-A||S000028555|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YIL133C	2.21183	CAT8	YIL133C|RPL16A|S000001395|N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YPL090C	2.19858	CAT8	YPL090C|RPS6A|S000006011|Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YKR092C	2.18736	CAT8	YKR092C|SRP40|S000001800|Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YLR108C	2.16465	CAT8	YLR108C||S000004098|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YKL118W	2.16301	CAT8	YKL118W||S000001601|Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2
YDR384C	2.16281	CAT8	YDR384C|ATO3|S000002792|Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YOR277C	2.13452	CAT8	YOR277C||S000005803|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YGR151C	2.12908	CAT8	YGR151C||S000003383|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YER001W	2.12314	CAT8	YER001W|MNN1|S000000803|Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YPL131W	2.12071	CAT8	YPL131W|RPL5|S000006052|Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YJL024C	2.11426	CAT8	YJL024C|APS3|S000003561|Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function
YIL169C	2.10447	CAT8	YIL169C||S000001431|Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YDR170C	2.10256	CAT8	YDR170C|SEC7|S000002577|Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YKL166C	2.09555	CAT8	YKL166C|TPK3|S000001649|cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk1p and Tpk2p
YIL053W	2.09236	CAT8	YIL053W|RHR2|S000001315|Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YBR096W	2.08866	CAT8	YBR096W||S000000300|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER
YOL125W	2.08698	CAT8	YOL125W|TRM13|S000005485|2'-O-methyltransferase responsible for modification of tRNA at position 4; exhibits no obvious similarity to other known methyltransferases
YOR349W	2.05768	CAT8	YOR349W|CIN1|S000005876|Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
YEL027W	2.05095	CAT8	YEL027W|CUP5|S000000753|Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YBL044W	2.04708	CAT8	YBL044W||S000000140|Putative protein of unknown function; YBL044W is not an essential protein
YBL069W	2.04201	CAT8	YBL069W|AST1|S000000165|Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts
YCR004C	2.04158	CAT8	YCR004C|YCP4|S000000597|Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIR013C	2.0189	CAT8	YIR013C|GAT4|S000001452|Protein containing GATA family zinc finger motifs
YDL191W	2.00822	CAT8	YDL191W|RPL35A|S000002350|Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YGL039W	2.00486	CAT8	YGL039W||S000003007|Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YPL178W	2.00466	CAT8	YPL178W|CBC2|S000006099|Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YEL067C	1.99311	CAT8	YEL067C||S000000793|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR018W	1.98793	CAT8	YNR018W|AIM38|S000005301|Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YER048C	1.96226	CAT8	YER048C|CAJ1|S000000850|Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YGL058W	1.95762	CAT8	YGL058W|RAD6|S000003026|Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (with Rad18p), sporulation, telomere silencing, and ubiquitin-mediated N-end rule protein degradation (with Ubr1p)
YGL145W	1.95506	CAT8	YGL145W|TIP20|S000003113|Peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane; interacts with Sec20p
YEL001C	1.94757	CAT8	YEL001C|IRC22|S000000727|Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YOL049W	1.94594	CAT8	YOL049W|GSH2|S000005409|Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
YGR242W	1.93256	CAT8	YGR242W||S000003474|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YLR333C	1.92934	CAT8	YLR333C|RPS25B|S000004325|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YGR180C	1.92357	CAT8	YGR180C|RNR4|S000003412|Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YML121W	1.91142	CAT8	YML121W|GTR1|S000004590|Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YOL039W	1.90829	CAT8	YOL039W|RPP2A|S000005399|Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YML043C	1.90388	CAT8	YML043C|RRN11|S000004507|Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YDR278C	1.90162	CAT8	YDR278C||S000002686|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR256C	1.88933	CAT8	YBR256C|RIB5|S000000460|Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YKR013W	1.88593	CAT8	YKR013W|PRY2|S000001721|Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YIL056W	1.87112	CAT8	YIL056W|VHR1|S000001318|Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YJL162C	1.86742	CAT8	YJL162C|JJJ2|S000003698|Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YFL037W	1.85559	CAT8	YFL037W|TUB2|S000001857|Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
YML123C	1.84301	CAT8	YML123C|PHO84|S000004592|High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YEL034C-A	1.83585	CAT8	YEL034C-A||S000028743|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A
YOL022C	1.82623	CAT8	YOL022C|TSR4|S000005382|Cytoplasmic protein of unknown function; essential gene in S288C, and non-essential with reduced growth rate in CEN.PK2; Null mutant accumulates 20S pre-rRNA
YMR083W	1.82203	CAT8	YMR083W|ADH3|S000004688|Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YPL256C	1.81513	CAT8	YPL256C|CLN2|S000006177|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YML088W	1.79148	CAT8	YML088W|UFO1|S000004553|F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YNL304W	1.77235	CAT8	YNL304W|YPT11|S000005248|Rab-type small GTPase that interacts with the C-terminal tail domain of Myo2p to mediate distribution of mitochondria to daughter cells
YOL040C	1.75685	CAT8	YOL040C|RPS15|S000005400|Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YGR181W	1.73806	CAT8	YGR181W|TIM13|S000003413|Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YGR287C	1.72783	CAT8	YGR287C||S000003519|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to alpha-D-glucosidase (maltase); authentic, non-tagged protein detected in purified mitochondria in high-throughput studies
YBR244W	1.72645	CAT8	YBR244W|GPX2|S000000448|Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YEL029C	1.72358	CAT8	YEL029C|BUD16|S000000755|Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YLL028W	1.72079	CAT8	YLL028W|TPO1|S000003951|Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YKR099W	1.70603	CAT8	YKR099W|BAS1|S000001807|Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YKL117W	1.70567	CAT8	YKL117W|SBA1|S000001600|Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity
YIL074C	1.70524	CAT8	YIL074C|SER33|S000001336|3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YLR367W	1.67666	CAT8	YLR367W|RPS22B|S000004359|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YGR241C	1.67007	CAT8	YGR241C|YAP1802|S000003473|Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YMR024W	1.66889	CAT8	YMR024W|MRPL3|S000004626|Mitochondrial ribosomal protein of the large subunit
YDR240C	1.66226	CAT8	YDR240C|SNU56|S000002648|Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex
YER088C-A	1.6561	CAT8	YER088C-A||S000028754|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR147W	1.64399	CAT8	YDR147W|EKI1|S000002554|Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway
YDR072C	1.64226	CAT8	YDR072C|IPT1|S000002479|Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YFL014W	1.63861	CAT8	YFL014W|HSP12|S000001880|Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways
YOL005C	1.60245	CAT8	YOL005C|RPB11|S000005365|RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YMR184W	1.60154	CAT8	YMR184W|ADD37|S000004796|Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene
YCR006C	1.59514	CAT8	YCR006C||S000000599|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL033W	1.58104	CAT8	YEL033W|MTC7|S000000759|Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant
YPL014W	1.57926	CAT8	YPL014W||S000005935|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YDR496C	1.57819	CAT8	YDR496C|PUF6|S000002904|Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA
YER025W	1.57188	CAT8	YER025W|GCD11|S000000827|Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met
YML071C	1.56476	CAT8	YML071C|COG8|S000004536|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDR075W	1.5624	CAT8	YDR075W|PPH3|S000002482|Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p
YFR031C-A	1.55587	CAT8	YFR031C-A|RPL2A|S000002104|Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YAL029C	1.55574	CAT8	YAL029C|MYO4|S000000027|One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YPL177C	1.55484	CAT8	YPL177C|CUP9|S000006098|Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YGL123C-A	1.54974	CAT8	YGL123C-A||S000028634|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YOR013W	1.53634	CAT8	YOR013W|IRC11|S000005539|Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci
YMR214W	1.53619	CAT8	YMR214W|SCJ1|S000004827|One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
YOR274W	1.5258	CAT8	YOR274W|MOD5|S000005800|Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms
YML103C	1.52313	CAT8	YML103C|NUP188|S000004571|Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p
YBR069C	1.51763	CAT8	YBR069C|TAT1|S000000273|Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YMR121C	1.51647	CAT8	YMR121C|RPL15B|S000004728|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YBR017C	1.51442	CAT8	YBR017C|KAP104|S000000221|Transportin, cytosolic karyopherin beta 2 involved in delivery of heterogeneous nuclear ribonucleoproteins to the nucleoplasm, binds rg-nuclear localization signals on Nab2p and Hrp1p, plays a role in cell-cycle progression
YGL123W	1.51366	CAT8	YGL123W|RPS2|S000003091|Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YPL112C	1.50831	CAT8	YPL112C|PEX25|S000006033|Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YGR280C	1.50614	CAT8	YGR280C|PXR1|S000003512|Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
YGR113W	1.50413	CAT8	YGR113W|DAM1|S000003345|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments
YOR107W	1.50324	CAT8	YOR107W|RGS2|S000005633|Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YKR012C	1.48542	CAT8	YKR012C||S000001720|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YMR142C	1.47808	CAT8	YMR142C|RPL13B|S000004750|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YMR143W	1.47692	CAT8	YMR143W|RPS16A|S000004751|Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YGR040W	1.45978	CAT8	YGR040W|KSS1|S000003272|Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YPL144W	1.45862	CAT8	YPL144W|POC4|S000006065|Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YGL034C	1.45237	CAT8	YGL034C||S000003002|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR015C	1.44624	CAT8	YMR015C|ERG5|S000004617|C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YPR170W-B	1.44593	CAT8	YPR170W-B||S000028515|Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YOL127W	1.42609	CAT8	YOL127W|RPL25|S000005487|Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YDR012W	1.41688	CAT8	YDR012W|RPL4B|S000002419|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins
YER048W-A	1.41489	CAT8	YER048W-A|ISD11|S000007237|Protein required for mitochondrial iron-sulfur cluster biosynthesis
YKL180W	1.41392	CAT8	YKL180W|RPL17A|S000001663|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YDR046C	1.41033	CAT8	YDR046C|BAP3|S000002453|Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
YPR074W-A	1.39926	CAT8	YPR074W-A||S000007631|Hypothetical protein identified by homology
YJL008C	1.39889	CAT8	YJL008C|CCT8|S000003545|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YDR041W	1.38892	CAT8	YDR041W|RSM10|S000002448|Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YNL043C	1.38166	CAT8	YNL043C||S000004988|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YGR253C	1.37946	CAT8	YGR253C|PUP2|S000003485|Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
YFR028C	1.37733	CAT8	YFR028C|CDC14|S000001924|Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
YKR074W	1.37566	CAT8	YKR074W|AIM29|S000001782|Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YGL040C	1.37038	CAT8	YGL040C|HEM2|S000003008|Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YKL007W	1.36451	CAT8	YKL007W|CAP1|S000001490|Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches
YDR112W	1.35899	CAT8	YDR112W|IRC2|S000002519|Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YDL213C	1.35771	CAT8	YDL213C|NOP6|S000002372|Putative RNA-binding protein implicated in ribosome biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes
YAR071W	1.35388	CAT8	YAR071W|PHO11|S000000094|One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YJL111W	1.34799	CAT8	YJL111W|CCT7|S000003647|Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YNL280C	1.34018	CAT8	YNL280C|ERG24|S000005224|C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YER009W	1.33971	CAT8	YER009W|NTF2|S000000811|Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
YLR026C	1.32938	CAT8	YLR026C|SED5|S000004016|cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins
YHR013C	1.31685	CAT8	YHR013C|ARD1|S000001055|Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YKL165C	1.31396	CAT8	YKL165C|MCD4|S000001648|Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YDR274C	1.30788	CAT8	YDR274C||S000002682|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML022W	1.30783	CAT8	YML022W|APT1|S000004484|Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis
YPR008W	1.3036	CAT8	YPR008W|HAA1|S000006212|Transcriptional activator involved in the transcription of TPO2, HSP30 and other genes encoding membrane stress proteins; involved in adaptation to weak acid stress
YBL092W	1.2933	CAT8	YBL092W|RPL32|S000000188|Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YKL052C	1.27322	CAT8	YKL052C|ASK1|S000001535|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases
YOR230W	1.26717	CAT8	YOR230W|WTM1|S000005756|Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
YJL188C	1.26471	CAT8	YJL188C|BUD19|S000003724|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YML115C	1.26368	CAT8	YML115C|VAN1|S000004583|Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
YGR094W	1.26145	CAT8	YGR094W|VAS1|S000003326|Mitochondrial and cytoplasmic valyl-tRNA synthetase
YPR035W	1.25592	CAT8	YPR035W|GLN1|S000006239|Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation
YDR023W	1.25514	CAT8	YDR023W|SES1|S000002430|Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YLR406C	1.254	CAT8	YLR406C|RPL31B|S000004398|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YER117W	1.2501	CAT8	YER117W|RPL23B|S000000919|Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins
YBL029W	1.24545	CAT8	YBL029W||S000000125|Non-essential protein of unknown function
YOL103W	1.23542	CAT8	YOL103W|ITR2|S000005463|Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YGR130C	1.22358	CAT8	YGR130C||S000003362|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)
YFL001W	1.22232	CAT8	YFL001W|DEG1|S000001895|Non-essential tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm
YIL163C	1.2189	CAT8	YIL163C||S000001425|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR135W-A	1.20801	CAT8	YMR135W-A||S000004743|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YML085C	1.20264	CAT8	YML085C|TUB1|S000004550|Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
YDR040C	1.20217	CAT8	YDR040C|ENA1|S000002447|P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YOR039W	1.19378	CAT8	YOR039W|CKB2|S000005565|Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
YBR009C	1.18972	CAT8	YBR009C|HHF1|S000000213|One of two identical histone H4 proteins (see also HHF2); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YMR177W	1.18658	CAT8	YMR177W|MMT1|S000004789|Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YKL051W	1.17529	CAT8	YKL051W|SFK1|S000001534|Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
YGR266W	1.17013	CAT8	YGR266W||S000003498|Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YFR009W	1.16889	CAT8	YFR009W|GCN20|S000001905|Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA
YEL055C	1.16737	CAT8	YEL055C|POL5|S000000781|DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA
YPL028W	1.16501	CAT8	YPL028W|ERG10|S000005949|Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
YDR390C	1.14415	CAT8	YDR390C|UBA2|S000002798|Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YGR293C	1.13339	CAT8	YGR293C||S000003525|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YPR062W	1.12741	CAT8	YPR062W|FCY1|S000006266|Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YEL038W	1.1219	CAT8	YEL038W|UTR4|S000000764|Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus
YDR016C	1.12167	CAT8	YDR016C|DAD1|S000002423|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis
YLR349W	1.12116	CAT8	YLR349W||S000004341|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YLR197W	1.11887	CAT8	YLR197W|SIK1|S000004187|Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YDR331W	1.11047	CAT8	YDR331W|GPI8|S000002739|ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog
YLL043W	1.10306	CAT8	YLL043W|FPS1|S000003966|Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
YBL040C	1.09777	CAT8	YBL040C|ERD2|S000000136|HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
YLR348C	1.07386	CAT8	YLR348C|DIC1|S000004340|Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YOR119C	1.07343	CAT8	YOR119C|RIO1|S000005645|Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
YHL020C	1.07078	CAT8	YHL020C|OPI1|S000001012|Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
YEL053C	1.06299	CAT8	YEL053C|MAK10|S000000779|Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible
YOR133W	1.05609	CAT8	YOR133W|EFT1|S000005659|Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YGR034W	1.05582	CAT8	YGR034W|RPL26B|S000003266|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YPR038W	1.04768	CAT8	YPR038W|IRC16|S000006242|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci
YJL107C	1.04764	CAT8	YJL107C||S000003643|Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YIL164C	1.04421	CAT8	YIL164C|NIT1|S000001426|Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene
YER021W	1.04153	CAT8	YER021W|RPN3|S000000823|Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
YER063W	1.04038	CAT8	YER063W|THO1|S000000865|Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation
YDR073W	1.036	CAT8	YDR073W|SNF11|S000002480|Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p
YJR065C	1.03253	CAT8	YJR065C|ARP3|S000003826|Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
YKL190W	1.03122	CAT8	YKL190W|CNB1|S000001673|Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1
YFR002W	1.03093	CAT8	YFR002W|NIC96|S000001898|Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p
YBR137W	1.03001	CAT8	YBR137W||S000000341|Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); YBR137W is not an essential gene
YDR091C	1.02824	CAT8	YDR091C|RLI1|S000002498|Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YJL138C	1.02518	CAT8	YJL138C|TIF2|S000003674|Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G
YOR030W	1.02362	CAT8	YOR030W|DFG16|S000005556|Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YDR153C	1.02263	CAT8	YDR153C|ENT5|S000002560|Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
YGL182C	1.02033	CAT8	YGL182C||S000003150|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C
YDL135C	1.02008	CAT8	YDL135C|RDI1|S000002294|Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p
YJL190C	1.02002	CAT8	YJL190C|RPS22A|S000003726|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YOR110W	1.01877	CAT8	YOR110W|TFC7|S000005636|One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes
YPR037C	1.01463	CAT8	YPR037C|ERV2|S000006241|Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
YPR025C	1.0125	CAT8	YPR025C|CCL1|S000006229|Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
YML063W	1.00886	CAT8	YML063W|RPS1B|S000004528|Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YDR451C	1.00858	CAT8	YDR451C|YHP1|S000002859|One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval
YLR301W	1.0044	CAT8	YLR301W||S000004292|Protein of unknown function that interacts with Sec72p
YBR078W	1.0014	CAT8	YBR078W|ECM33|S000000282|GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p
YDR417C	1.00127	CAT8	YDR417C||S000002825|Hypothetical protein
YDL082W	0.993923	CAT8	YDL082W|RPL13A|S000002240|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein
YDR111C	0.993407	CAT8	YDR111C|ALT2|S000002518|Putative alanine transaminase (glutamic pyruvic transaminase)
YNL079C	0.989859	CAT8	YNL079C|TPM1|S000005023|Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YPL239W	0.988986	CAT8	YPL239W|YAR1|S000006160|Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YDL083C	0.982581	CAT8	YDL083C|RPS16B|S000002241|Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins
YPR010C	0.981129	CAT8	YPR010C|RPA135|S000006214|RNA polymerase I subunit A135
YMR221C	0.979342	CAT8	YMR221C|FMP42|S000004834|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy
YGL012W	0.978965	CAT8	YGL012W|ERG4|S000002980|C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YGR131W	0.971818	CAT8	YGR131W||S000003363|Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YPR148C	0.969515	CAT8	YPR148C||S000006352|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR157C	0.965843	CAT8	YOR157C|PUP1|S000005683|Endopeptidase with trypsin-like activity that cleaves after basic residues; beta 2 subunit of 20S proteasome, synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YJR126C	0.945451	CAT8	YJR126C|VPS70|S000003887|Protein of unknown function involved in vacuolar protein sorting
YPL143W	0.944365	CAT8	YPL143W|RPL33A|S000006064|N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YGR214W	0.937371	CAT8	YGR214W|RPS0A|S000003446|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YNL131W	0.927341	CAT8	YNL131W|TOM22|S000005075|Component of the TOM (translocase of outer membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between the TOM and TIM complexes
YGR128C	0.924018	CAT8	YGR128C|UTP8|S000003360|Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YOR321W	0.923681	CAT8	YOR321W|PMT3|S000005848|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals
YPR156C	0.922962	CAT8	YPR156C|TPO3|S000006360|Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily
YNR013C	0.922929	CAT8	YNR013C|PHO91|S000005296|Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YDL078C	0.922028	CAT8	YDL078C|MDH3|S000002236|Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YML069W	0.914592	CAT8	YML069W|POB3|S000004534|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which facilitates RNA Pol II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure; interacts with DNA polymerase alpha (Pol1p)
YPL215W	0.913284	CAT8	YPL215W|CBP3|S000006136|Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p
YNL078W	0.912287	CAT8	YNL078W|NIS1|S000005022|Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
YPR170W-A	0.910086	CAT8	YPR170W-A||S000028861|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YER073W	0.909975	CAT8	YER073W|ALD5|S000000875|Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YLR453C	0.908779	CAT8	YLR453C|RIF2|S000004445|Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation
YMR251W-A	0.906599	CAT8	YMR251W-A|HOR7|S000004864|Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YDL240W	0.905746	CAT8	YDL240W|LRG1|S000002399|Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YPR195C	0.901975	CAT8	YPR195C||S000006399|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL056W	0.900873	CAT8	YEL056W|HAT2|S000000782|Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing
YGL207W	0.899356	CAT8	YGL207W|SPT16|S000003175|Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structure
YIL123W	0.894982	CAT8	YIL123W|SIM1|S000001385|Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YKL122C	0.887466	CAT8	YKL122C|SRP21|S000001605|Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YPR118W	0.884747	CAT8	YPR118W|MRI1|S000006322|Methylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
YPL145C	0.882229	CAT8	YPL145C|KES1|S000006066|Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
YLL021W	0.873052	CAT8	YLL021W|SPA2|S000003944|Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
YML126C	0.870103	CAT8	YML126C|ERG13|S000004595|3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis
YDR449C	0.867583	CAT8	YDR449C|UTP6|S000002857|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YCL022C	0.86337	CAT8	YCL022C||S000000527|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
YDL242W	0.853896	CAT8	YDL242W||S000002401|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR320W	0.852763	CAT8	YMR320W||S000004939|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR357W	0.850522	CAT8	YLR357W|RSC2|S000004349|Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
YBR268W	0.846871	CAT8	YBR268W|MRPL37|S000000472|Mitochondrial ribosomal protein of the large subunit
YNL229C	0.83952	CAT8	YNL229C|URE2|S000005173|Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; altered form of Ure2p creates [URE3] prion
YER019C-A	0.833125	CAT8	YER019C-A|SBH2|S000002127|Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YDR088C	0.83168	CAT8	YDR088C|SLU7|S000002495|RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YNL098C	0.831529	CAT8	YNL098C|RAS2|S000005042|GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
YPL207W	0.831318	CAT8	YPL207W|TYW1|S000006128|Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YGL200C	0.825222	CAT8	YGL200C|EMP24|S000003168|Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YNR061C	0.824908	CAT8	YNR061C||S000005344|Putative protein of unknown function
YOL092W	0.82128	CAT8	YOL092W||S000005452|Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W; deletion mutant has no detectable phenotype
YPL198W	0.818894	CAT8	YPL198W|RPL7B|S000006119|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YDL031W	0.818497	CAT8	YDL031W|DBP10|S000002189|Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis
YBR198C	0.815697	CAT8	YBR198C|TAF5|S000000402|Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
YKL145W	0.807008	CAT8	YKL145W|RPT1|S000001628|One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1p
YKL062W	0.804997	CAT8	YKL062W|MSN4|S000001545|Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression
YML119W	0.796019	CAT8	YML119W||S000004588|Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YGR097W	0.79295	CAT8	YGR097W|ASK10|S000003329|Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes
YOR038C	0.788371	CAT8	YOR038C|HIR2|S000005564|Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
YPR171W	0.787435	CAT8	YPR171W|BSP1|S000006375|Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YGL035C	0.786708	CAT8	YGL035C|MIG1|S000003003|Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YML102W	0.784736	CAT8	YML102W|CAC2|S000004570|Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
YEL032W	0.783734	CAT8	YEL032W|MCM3|S000000758|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGL111W	0.782527	CAT8	YGL111W|NSA1|S000003079|Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YLR083C	0.780777	CAT8	YLR083C|EMP70|S000004073|Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions
YBR243C	0.780218	CAT8	YBR243C|ALG7|S000000447|UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YBR010W	0.779683	CAT8	YBR010W|HHT1|S000000214|One of two identical histone H3 proteins (see also HHT2); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YHR136C	0.777275	CAT8	YHR136C|SPL2|S000001178|Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YDR427W	0.771184	CAT8	YDR427W|RPN9|S000002835|Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects
YDR028C	0.766126	CAT8	YDR028C|REG1|S000002435|Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes
YGL054C	0.753995	CAT8	YGL054C|ERV14|S000003022|Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon
YJL106W	0.750347	CAT8	YJL106W|IME2|S000003642|Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YKR093W	0.744029	CAT8	YKR093W|PTR2|S000001801|Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YML024W	0.74312	CAT8	YML024W|RPS17A|S000004486|Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein
YGR148C	0.739365	CAT8	YGR148C|RPL24B|S000003380|Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YMR144W	0.736727	CAT8	YMR144W||S000004752|Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YNL191W	0.731495	CAT8	YNL191W|DUG3|S000005135|Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
YLR081W	0.729798	CAT8	YLR081W|GAL2|S000004071|Galactose permease, required for utilization of galactose; also able to transport glucose
YHR005C-A	0.728324	CAT8	YHR005C-A|MRS11|S000003530|Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YBR023C	0.726601	CAT8	YBR023C|CHS3|S000000227|Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YIL124W	0.721075	CAT8	YIL124W|AYR1|S000001386|NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones
YGR255C	0.720016	CAT8	YGR255C|COQ6|S000003487|Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
YMR212C	0.719652	CAT8	YMR212C|EFR3|S000004825|Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies and is phosphorylated
YDL076C	0.719558	CAT8	YDL076C|RXT3|S000002234|Subunit of the RPD3L complex; involved in histone deacetylation
YOL121C	0.716415	CAT8	YOL121C|RPS19A|S000005481|Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
YGR294W	0.715029	CAT8	YGR294W|PAU12|S000003526|Hypothetical protein
YPR170C	0.714746	CAT8	YPR170C||S000006374|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YGL161C	0.714139	CAT8	YGL161C|YIP5|S000003129|Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
YLR133W	0.709773	CAT8	YLR133W|CKI1|S000004123|Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway
YLL050C	0.708126	CAT8	YLL050C|COF1|S000003973|Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YMR099C	0.70591	CAT8	YMR099C||S000004705|Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS
YMR277W	0.70492	CAT8	YMR277W|FCP1|S000004890|Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YLR341W	0.702247	CAT8	YLR341W|SPO77|S000004333|Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YOL122C	0.698185	CAT8	YOL122C|SMF1|S000005482|Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins
YNL287W	0.698017	CAT8	YNL287W|SEC21|S000005231|Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
YKL097C	0.697725	CAT8	YKL097C||S000001580|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YEL014C	0.689703	CAT8	YEL014C||S000000740|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR015W	0.686605	CAT8	YJR015W||S000003776|Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene
YDL137W	0.684631	CAT8	YDL137W|ARF2|S000002296|ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p
YMR247C	0.682435	CAT8	YMR247C|RKR1|S000004861|Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene
YGL100W	0.67722	CAT8	YGL100W|SEH1|S000003068|Nuclear pore protein that is part of the evolutionarily conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); homologous to Sec13p
YKR026C	0.675153	CAT8	YKR026C|GCN3|S000001734|Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YEL062W	0.674171	CAT8	YEL062W|NPR2|S000000788|Protein with a possible role in regulating expression of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequences; null mutant is resistant to cisplatin and doxorubicin
YNL075W	0.670321	CAT8	YNL075W|IMP4|S000005019|Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YOR101W	0.668838	CAT8	YOR101W|RAS1|S000005627|GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YLR227C	0.666748	CAT8	YLR227C|ADY4|S000004217|Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane
YOR315W	0.66589	CAT8	YOR315W|SFG1|S000005842|Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YNR075W	0.66527	CAT8	YNR075W|COS10|S000005358|Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YCL058C	0.665137	CAT8	YCL058C|FYV5|S000000563|Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YIL149C	0.663581	CAT8	YIL149C|MLP2|S000001411|Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
YGL038C	0.661178	CAT8	YGL038C|OCH1|S000003006|Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
YIR020W-A	0.659356	CAT8	YIR020W-A||S000007241|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YOR352W	0.658324	CAT8	YOR352W||S000005879|Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR031C-A	0.653382	CAT8	YGR031C-A|NAG1|S000028636|Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; null is hypersensitive to calcofluor white; overlaps the uncharacterized ORF YGR031W
YDR008C	0.651912	CAT8	YDR008C||S000002415|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR122W-A	0.649448	CAT8	YMR122W-A||S000007524|Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum
YLL022C	0.646519	CAT8	YLL022C|HIF1|S000003945|Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing
YGR017W	0.646056	CAT8	YGR017W||S000003249|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YEL063C	0.64422	CAT8	YEL063C|CAN1|S000000789|Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance
YHR083W	0.643218	CAT8	YHR083W|SAM35|S000001125|Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane
YGL252C	0.641087	CAT8	YGL252C|RTG2|S000003221|Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p
YDL145C	0.640581	CAT8	YDL145C|COP1|S000002304|Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YMR076C	0.640542	CAT8	YMR076C|PDS5|S000004681|Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes in an interdependent manner, may function as a protein-protein interaction scaffold
YMR082C	0.636874	CAT8	YMR082C||S000004687|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL266W	0.635728	CAT8	YPL266W|DIM1|S000006187|Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing
YDR276C	0.631974	CAT8	YDR276C|PMP3|S000002684|Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YJL041W	0.631574	CAT8	YJL041W|NSP1|S000003577|Essential component of the nuclear pore complex, which mediates nuclear import and export
YBL012C	0.626099	CAT8	YBL012C||S000000108|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER092W	0.62333	CAT8	YER092W|IES5|S000000894|Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
YPR051W	0.619459	CAT8	YPR051W|MAK3|S000006255|Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus
YBL039C	0.619443	CAT8	YBL039C|URA7|S000000135|Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis
YPR181C	0.616914	CAT8	YPR181C|SEC23|S000006385|GTPase-activating protein; component of the Sec23p-Sec24p heterodimeric complex of the COPII vesicle coat, involved in ER to Golgi transport and autophagy; stimulates the GDP-bound form of Sar1p
YLR048W	0.612765	CAT8	YLR048W|RPS0B|S000004038|Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YLR056W	0.611215	CAT8	YLR056W|ERG3|S000004046|C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources
YDR365C	0.608331	CAT8	YDR365C|ESF1|S000002773|Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YHL004W	0.608269	CAT8	YHL004W|MRP4|S000000996|Mitochondrial ribosomal protein of the small subunit
YGR025W	0.607674	CAT8	YGR025W||S000003257|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL200C	0.607442	CAT8	YJL200C|ACO2|S000003736|Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YBL027W	0.607362	CAT8	YBL027W|RPL19B|S000000123|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YMR029C	0.605757	CAT8	YMR029C|FAR8|S000004631|Protein involved in G1 cell cycle arrest in response to pheromone, in a pathway different from the Far1p-dependent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
YDR498C	0.601639	CAT8	YDR498C|SEC20|S000002906|Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; forms a complex with the cytosolic Tip20p
YAR029W	0.600579	CAT8	YAR029W||S000000077|Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBL028C	0.599273	CAT8	YBL028C||S000000124|Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
YPR126C	0.595562	CAT8	YPR126C||S000006330|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR093C	0.594661	CAT8	YLR093C|NYV1|S000004083|v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane
YGL179C	0.590891	CAT8	YGL179C|TOS3|S000003147|Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YOR051C	0.587132	CAT8	YOR051C||S000005577|Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YDR208W	0.586733	CAT8	YDR208W|MSS4|S000002616|Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
YGL258W	0.585892	CAT8	YGL258W|VEL1|S000003227|Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YHR081W	0.580783	CAT8	YHR081W|LRP1|S000001123|Substrate-specific nuclear cofactor for exosome activity in the processing of stable RNAs; required for telomere length maintenance; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination
YNR074C	0.578728	CAT8	YNR074C|AIF1|S000005357|Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
YAR020C	0.577181	CAT8	YAR020C|PAU7|S000000073|Part of 23-member seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme
YLR335W	0.575638	CAT8	YLR335W|NUP2|S000004327|Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
YGL088W	0.574073	CAT8	YGL088W||S000003056|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
YDR534C	0.572788	CAT8	YDR534C|FIT1|S000002942|Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YEL013W	0.572511	CAT8	YEL013W|VAC8|S000000739|Phosphorylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
YDR297W	0.569257	CAT8	YDR297W|SUR2|S000002705|Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis
YER109C	0.568654	CAT8	YER109C|FLO8|S000000911|Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YCR101C	0.567417	CAT8	YCR101C||S000000698|Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
YGL247W	0.567413	CAT8	YGL247W|BRR6|S000003216|Essential nuclear envelope integral membrane protein required for nuclear transport; depletion alters nucleoporin distribution and nuclear envelope morphology, suggesting a role in the spatial organization of nuclear pores
YKL128C	0.566122	CAT8	YKL128C|PMU1|S000001611|Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YDL212W	0.564653	CAT8	YDL212W|SHR3|S000002371|Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
YDR207C	0.563583	CAT8	YDR207C|UME6|S000002615|Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p
YMR039C	0.562661	CAT8	YMR039C|SUB1|S000004642|Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations
YGR090W	0.561998	CAT8	YGR090W|UTP22|S000003322|Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YIR019C	0.557707	CAT8	YIR019C|MUC1|S000001458|GPI-anchored cell surface glycoprotein (flocculin) required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p)
YOL086W-A	0.555858	CAT8	YOL086W-A||S000007626|Putative protein of unknown function; identified by homology
YDR025W	0.553746	CAT8	YDR025W|RPS11A|S000002432|Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YKL113C	0.545596	CAT8	YKL113C|RAD27|S000001596|5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family
YMR049C	0.544682	CAT8	YMR049C|ERB1|S000004652|Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YJL039C	0.542542	CAT8	YJL039C|NUP192|S000003576|Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205
YJL187C	0.540104	CAT8	YJL187C|SWE1|S000003723|Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate
YLR110C	0.538584	CAT8	YLR110C|CCW12|S000004100|Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YPR194C	0.534788	CAT8	YPR194C|OPT2|S000006398|Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans
YLR437C	0.5299	CAT8	YLR437C||S000004429|Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YLR401C	0.527503	CAT8	YLR401C|DUS3|S000004393|Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region
YMR119W	0.52296	CAT8	YMR119W|ASI1|S000004725|Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YDR172W	0.52133	CAT8	YDR172W|SUP35|S000002579|Translation termination factor eRF3; altered protein conformation creates the [PSI(+)] prion, a dominant cytoplasmically inherited protein aggregate that alters translational fidelity and creates a nonsense suppressor phenotype
YMR215W	0.518943	CAT8	YMR215W|GAS3|S000004828|Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YMR208W	0.518383	CAT8	YMR208W|ERG12|S000004821|Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YCR024C-B	0.515902	CAT8	YCR024C-B||S000028818|Putative protein of unknown function; identified by expression profiling and mass spectrometry
YNL234W	0.514036	CAT8	YNL234W||S000005178|Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YOR050C	0.513841	CAT8	YOR050C||S000005576|Hypothetical protein
YDL058W	0.513787	CAT8	YDL058W|USO1|S000002216|Essential protein involved in intracellular protein transport, coiled-coil protein necessary for transport from ER to Golgi; required for assembly of the ER-to-Golgi SNARE complex
YOR077W	0.507516	CAT8	YOR077W|RTS2|S000005603|Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
YDL112W	0.50316	CAT8	YDL112W|TRM3|S000002270|2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs
YLR099W-A	0.503037	CAT8	YLR099W-A||S000007618|Putative protein of unknown function
YKL164C	0.50258	CAT8	YKL164C|PIR1|S000001647|O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YBL024W	0.502075	CAT8	YBL024W|NCL1|S000000120|S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120
YGR271C-A	0.500283	CAT8	YGR271C-A|EFG1|S000007608|Protein of unknown function; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YHR021C	0.497634	CAT8	YHR021C|RPS27B|S000001063|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YGR179C	0.494623	CAT8	YGR179C|OKP1|S000003411|Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YDL228C	0.490416	CAT8	YDL228C||S000002387|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1
YJL007C	0.486023	CAT8	YJL007C||S000003544|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR229C	0.482634	CAT8	YLR229C|CDC42|S000004219|Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
YPR182W	0.478302	CAT8	YPR182W|SMX3|S000006386|Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F
YDR292C	0.477586	CAT8	YDR292C|SRP101|S000002700|Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
YDL121C	0.477031	CAT8	YDL121C||S000002279|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic retiuculum; YDL121C is not an essential protein
YBL004W	0.475139	CAT8	YBL004W|UTP20|S000000100|Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
YJL198W	0.473883	CAT8	YJL198W|PHO90|S000003734|Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YOR234C	0.473142	CAT8	YOR234C|RPL33B|S000005760|Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YNL016W	0.472871	CAT8	YNL016W|PUB1|S000004961|Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YJR001W	0.472547	CAT8	YJR001W|AVT1|S000003761|Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YER178W	0.47238	CAT8	YER178W|PDA1|S000000980|E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
YBR300C	0.470818	CAT8	YBR300C||S000000504|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YLR432W	0.468667	CAT8	YLR432W|IMD3|S000004424|Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YDR145W	0.466456	CAT8	YDR145W|TAF12|S000002552|Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YNL148C	0.466229	CAT8	YNL148C|ALF1|S000005092|Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
YOR012W	0.465488	CAT8	YOR012W||S000005538|Putative protein of unknown function
YKL201C	0.461147	CAT8	YKL201C|MNN4|S000001684|Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases
YER064C	0.460731	CAT8	YER064C||S000000866|Non-essential nuclear protein; null mutation has global effects on transcription
YGR267C	0.460159	CAT8	YGR267C|FOL2|S000003499|GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
YIL051C	0.45995	CAT8	YIL051C|MMF1|S000001313|Mitochondrial protein involved in maintenance of the mitochondrial genome
YDR201W	0.459556	CAT8	YDR201W|SPC19|S000002609|Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body
YJL136C	0.457806	CAT8	YJL136C|RPS21B|S000003672|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YGR106C	0.456109	CAT8	YGR106C|VOA1|S000003338|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YMR016C	0.455881	CAT8	YMR016C|SOK2|S000004618|Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors
YDR099W	0.454967	CAT8	YDR099W|BMH2|S000002506|14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YGR083C	0.454726	CAT8	YGR083C|GCD2|S000003315|Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YOR369C	0.452306	CAT8	YOR369C|RPS12|S000005896|Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YOR014W	0.451903	CAT8	YOR014W|RTS1|S000005540|B-type regulatory subunit of protein phosphatase 2A (PP2A); homolog of the mammalian B' subunit of PP2A
YMR100W	0.449714	CAT8	YMR100W|MUB1|S000004706|Protein of unknown function, deletion causes multi-budding phenotype; has similarity to Aspergillus nidulans samB gene
YML065W	0.449448	CAT8	YML065W|ORC1|S000004530|Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
YDR007W	0.447056	CAT8	YDR007W|TRP1|S000002414|Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA)
YMR315W	0.443123	CAT8	YMR315W||S000004932|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YMR315W is not an essential gene
YBR049C	0.442812	CAT8	YBR049C|REB1|S000000253|RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription
YMR319C	0.442365	CAT8	YMR319C|FET4|S000004938|Low-affinity Fe(II) transporter of the plasma membrane
YDR454C	0.441683	CAT8	YDR454C|GUK1|S000002862|Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YBR154C	0.441011	CAT8	YBR154C|RPB5|S000000358|RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
YOR158W	0.440985	CAT8	YOR158W|PET123|S000005684|Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
YLL027W	0.440204	CAT8	YLL027W|ISA1|S000003950|Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources
YMR173W	0.439433	CAT8	YMR173W|DDR48|S000004784|DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS
YCR102W-A	0.437246	CAT8	YCR102W-A||S000007231|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR004W	0.43655	CAT8	YGR004W|PEX31|S000003236|Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p
YIL121W	0.436107	CAT8	YIL121W|QDR2|S000001383|Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
YJL004C	0.435243	CAT8	YJL004C|SYS1|S000003541|Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
YFR051C	0.432857	CAT8	YFR051C|RET2|S000001947|Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YFL010W-A	0.432817	CAT8	YFL010W-A|AUA1|S000001955|Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
YOL104C	0.431386	CAT8	YOL104C|NDJ1|S000005464|Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution (interference), sister chromatid cohesion at meiotic telomeres, and segregation of small chromosomes
YEL021W	0.430949	CAT8	YEL021W|URA3|S000000747|Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound
YLR230W	0.428307	CAT8	YLR230W||S000004220|Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
YMR283C	0.427743	CAT8	YMR283C|RIT1|S000004896|2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
YJR099W	0.424297	CAT8	YJR099W|YUH1|S000003860|Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p
YGR107W	0.423067	CAT8	YGR107W||S000003339|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL125W	0.421174	CAT8	YGL125W|MET13|S000003093|Isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway
YAL023C	0.419	CAT8	YAL023C|PMT2|S000000021|Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YFR048W	0.418764	CAT8	YFR048W|RMD8|S000001944|Cytosolic protein required for sporulation
YOL054W	0.416247	CAT8	YOL054W|PSH1|S000005415|Nuclear protein, putative RNA polymerase II elongation factor; isolated as Pob3p/Spt16p-binding protein
YAL053W	0.415472	CAT8	YAL053W|FLC2|S000000049|Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YKR001C	0.415352	CAT8	YKR001C|VPS1|S000001709|Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, late Golgi-retention of some proteins, regulating peroxisome biogenesis
YHR143W-A	0.41432	CAT8	YHR143W-A|RPC10|S000001185|RNA polymerase subunit, found in RNA polymerase complexes I, II, and III
YPR033C	0.413232	CAT8	YPR033C|HTS1|S000006237|Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence
YBR112C	0.41197	CAT8	YBR112C|CYC8|S000000316|General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YBR202W	0.411901	CAT8	YBR202W|MCM7|S000000406|Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YOR011W	0.410588	CAT8	YOR011W|AUS1|S000005537|Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YIL119C	0.410094	CAT8	YIL119C|RPI1|S000001381|Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation
YLR171W	0.410015	CAT8	YLR171W||S000004161|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR066W	0.408991	CAT8	YJR066W|TOR1|S000003827|PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis
YBR066C	0.408806	CAT8	YBR066C|NRG2|S000000270|Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YFL010C	0.408713	CAT8	YFL010C|WWM1|S000001884|WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes Gi phase growth arrest and clonal death that is suppressed by overexpression of MCA1
YMR173W-A	0.407627	CAT8	YMR173W-A||S000004785|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W
YIR020C	0.406171	CAT8	YIR020C||S000001459|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL100C	0.405271	CAT8	YBL100C||S000000196|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1
YMR172C-A	0.40265	CAT8	YMR172C-A||S000004782|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL105W	0.402195	CAT8	YJL105W|SET4|S000003641|Protein of unknown function, contains a SET domain
YGL262W	0.398684	CAT8	YGL262W||S000003231|Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene
YJR057W	0.39838	CAT8	YJR057W|CDC8|S000003818|Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
YCR016W	0.398308	CAT8	YCR016W||S000000609|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; YCR016W is not an essential gene
YER133W	0.397295	CAT8	YER133W|GLC7|S000000935|Catalytic subunit of type 1 serine/threonine protein phosphatase, involved in many processes including glycogen metabolism, sporulation, and mitosis; interacts with multiple regulatory subunits; predominantly isolated with Sds22p
YIL137C	0.395194	CAT8	YIL137C|TMA108|S000001399|Protein that associates with ribosomes; putative metalloprotease
YNL040W	0.394218	CAT8	YNL040W||S000004985|Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene
YMR067C	0.393889	CAT8	YMR067C|UBX4|S000004671|UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p
YBR118W	0.389582	CAT8	YBR118W|TEF2|S000000322|Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YBL011W	0.389238	CAT8	YBL011W|SCT1|S000000107|Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed
YJL143W	0.38851	CAT8	YJL143W|TIM17|S000003679|Essential constituent of the mitochondrial inner membrane presequence translocase; interacts with Pam18p to recruit the presequence translocase-associated motor (PAM complex) and also required for protein sorting during import
YNL090W	0.388451	CAT8	YNL090W|RHO2|S000005034|Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
YKL127W	0.38499	CAT8	YKL127W|PGM1|S000001610|Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism
YDR165W	0.384546	CAT8	YDR165W|TRM82|S000002572|Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNA
YHL006C	0.383763	CAT8	YHL006C|SHU1|S000000998|Protein of unassigned function involved in mutation suppression, important for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation; associates with Shu2p, Psy3p, and Csm2p
YCR008W	0.383174	CAT8	YCR008W|SAT4|S000000601|Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p
YOR025W	0.38144	CAT8	YOR025W|HST3|S000005551|Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YCR095C	0.380196	CAT8	YCR095C|OCA4|S000000691|Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YGL253W	0.380043	CAT8	YGL253W|HXK2|S000003222|Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YML093W	0.380038	CAT8	YML093W|UTP14|S000004558|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YIR010W	0.378407	CAT8	YIR010W|DSN1|S000001449|Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
YHL009C	0.377606	CAT8	YHL009C|YAP3|S000001001|Basic leucine zipper (bZIP) transcription factor
YOR043W	0.370819	CAT8	YOR043W|WHI2|S000005569|Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YDR089W	0.368673	CAT8	YDR089W||S000002496|Protein of unknown function; deletion confers resistance to Nickel
YGR156W	0.368656	CAT8	YGR156W|PTI1|S000003388|Pta1p Interacting protein
YER034W	0.366988	CAT8	YER034W||S000000836|Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage
YHR137W	0.364694	CAT8	YHR137W|ARO9|S000001179|Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YDL043C	0.36458	CAT8	YDL043C|PRP11|S000002201|Subunit of the SF3a splicing factor complex, required for spliceosome assembly
YER174C	0.363709	CAT8	YER174C|GRX4|S000000976|Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage
YBR143C	0.363195	CAT8	YBR143C|SUP45|S000000347|Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YJL173C	0.363006	CAT8	YJL173C|RFA3|S000003709|Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
YJL216C	0.361948	CAT8	YJL216C||S000003752|Protein of unknown function, similar to alpha-D-glucosidases; transcriptionally activated by both Pdr8p and Yrm1p, along with transporters and other genes involved in the pleiotropic drug resistance (PDR) phenomenon
YMR006C	0.361649	CAT8	YMR006C|PLB2|S000004608|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine
YNL266W	0.360856	CAT8	YNL266W||S000005210|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C
YKL030W	0.359588	CAT8	YKL030W||S000001513|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
YJL222W	0.358023	CAT8	YJL222W|VTH2|S000003758|Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting
YLR206W	0.357323	CAT8	YLR206W|ENT2|S000004196|Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YHR031C	0.35446	CAT8	YHR031C|RRM3|S000001073|DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YDR535C	0.353006	CAT8	YDR535C||S000002943|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YJL157C	0.351741	CAT8	YJL157C|FAR1|S000003693|Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YBR093C	0.351623	CAT8	YBR093C|PHO5|S000000297|Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YNL251C	0.348647	CAT8	YNL251C|NRD1|S000005195|RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
YJL218W	0.345271	CAT8	YJL218W||S000003754|Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
YJL115W	0.343656	CAT8	YJL115W|ASF1|S000003651|Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YLR168C	0.34354	CAT8	YLR168C|AIM30|S000004158|Putative protein of unknown function that may be involved in intramitochondrial sorting; similar to Ups1p and to human PRELI; GFP-tagged protein localizes to mitochondria; required for wild-type respiratory growth
YML064C	0.341846	CAT8	YML064C|TEM1|S000004529|GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
YBR084C-A	0.341838	CAT8	YBR084C-A|RPL19A|S000002156|Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal
YPL030W	0.339136	CAT8	YPL030W|TRM44|S000005951|tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
YDL163W	0.338303	CAT8	YDL163W||S000002322|Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
YDR174W	0.338186	CAT8	YDR174W|HMO1|S000002581|Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase
YDR158W	0.337863	CAT8	YDR158W|HOM2|S000002565|Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YKR072C	0.333519	CAT8	YKR072C|SIS2|S000001780|Negative regulatory subunit of the protein phosphatase 1 Ppz1p; involved in ion homeostasis and cell cycle progression
YOR076C	0.332729	CAT8	YOR076C|SKI7|S000005602|Putative GTPase that mediates interactions via its N-terminus between the exosome and Ski complex (Ski2p, Ski3p, Ski8p) which operate in the 3'-to-5' mRNA-decay pathway; cytoplasmic protein required for degrading nonstop mRNAs
YGR026W	0.332228	CAT8	YGR026W||S000003258|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YER016W	0.331779	CAT8	YER016W|BIM1|S000000818|Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YBL036C	0.331621	CAT8	YBL036C||S000000132|Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS
YLR282C	0.331017	CAT8	YLR282C||S000004272|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition
YOL087C	0.326237	CAT8	YOL087C||S000005447|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
YBR079C	0.325648	CAT8	YBR079C|RPG1|S000000283|Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YOL012C	0.325027	CAT8	YOL012C|HTZ1|S000005372|Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YBR113W	0.322816	CAT8	YBR113W||S000000317|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8
YML075C	0.320132	CAT8	YML075C|HMG1|S000004540|One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YFL005W	0.316252	CAT8	YFL005W|SEC4|S000001889|Secretory vesicle-associated Rab GTPase essential for exocytosis; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YGR249W	0.316029	CAT8	YGR249W|MGA1|S000003481|Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YDR150W	0.312549	CAT8	YDR150W|NUM1|S000002557|Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
YKR023W	0.312017	CAT8	YKR023W||S000001731|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR104C	0.311407	CAT8	YJR104C|SOD1|S000003865|Cytosolic superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans
YBR068C	0.310701	CAT8	YBR068C|BAP2|S000000272|High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains
YGR021W	0.310592	CAT8	YGR021W||S000003253|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL235C	0.308703	CAT8	YNL235C||S000005179|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex
YDL164C	0.308589	CAT8	YDL164C|CDC9|S000002323|DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
YMR136W	0.30724	CAT8	YMR136W|GAT2|S000004744|Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
YMR003W	0.306712	CAT8	YMR003W|AIM34|S000004605|Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YGR259C	0.306458	CAT8	YGR259C||S000003491|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W
YKL091C	0.303645	CAT8	YKL091C||S000001574|Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YLR420W	0.300844	CAT8	YLR420W|URA4|S000004412|Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate
YIL064W	0.300269	CAT8	YIL064W||S000001326|Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
YIL008W	0.300264	CAT8	YIL008W|URM1|S000001270|Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YDR346C	0.300182	CAT8	YDR346C|SVF1|S000002754|Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis
YLR011W	0.3001	CAT8	YLR011W|LOT6|S000004001|FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YBR058C-A	0.297012	CAT8	YBR058C-A|TSC3|S000007521|Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis
YMR043W	0.294417	CAT8	YMR043W|MCM1|S000004646|Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes
YPL084W	0.294398	CAT8	YPL084W|BRO1|S000006005|Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes
YOR095C	0.293548	CAT8	YOR095C|RKI1|S000005621|Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
YMR237W	0.293526	CAT8	YMR237W|BCH1|S000004850|Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes
YIR007W	0.289469	CAT8	YIR007W||S000001446|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene
YNR038W	0.287972	CAT8	YNR038W|DBP6|S000005321|Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family
YOL161C	0.287933	CAT8	YOL161C|PAU20|S000005521|Hypothetical protein
YCR047C	0.284918	CAT8	YCR047C|BUD23|S000000643|Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YCR102C	0.284375	CAT8	YCR102C||S000000699|Putative protein of unknown function; involved in copper metabolism; similar to C.carbonum toxD gene; YCR102C is not an essential gene
YPL225W	0.284121	CAT8	YPL225W||S000006146|Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLL064C	0.283796	CAT8	YLL064C|PAU18|S000003987|Hypothetical protein
YNL099C	0.283361	CAT8	YNL099C|OCA1|S000005043|Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA
YGR279C	0.280721	CAT8	YGR279C|SCW4|S000003511|Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YKL090W	0.279372	CAT8	YKL090W|CUE2|S000001573|Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YOR335C	0.279202	CAT8	YOR335C|ALA1|S000005862|Cytoplasmic alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
YLR099C	0.277896	CAT8	YLR099C|ICT1|S000004089|Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress
YNL147W	0.276036	CAT8	YNL147W|LSM7|S000005091|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YJL222W-A	0.273845	CAT8	YJL222W-A||S000028663|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL223C	0.272712	CAT8	YJL223C|PAU1|S000003759|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YPR142C	0.272174	CAT8	YPR142C||S000006346|Hypothetical protein; open reading frame overlaps 5' end of essential RRP15 gene required for ribosomal RNA processing
YBR085W	0.27072	CAT8	YBR085W|AAC3|S000000289|Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration
YCL021W-A	0.268774	CAT8	YCL021W-A||S000007549|Putative protein of unknown function
YJR098C	0.26764	CAT8	YJR098C||S000003859|Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL059C	0.265542	CAT8	YDL059C|RAD59|S000002217|Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p
YDL187C	0.264344	CAT8	YDL187C||S000002346|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL272C	0.262132	CAT8	YNL272C|SEC2|S000005216|Guanyl-nucleotide exchange factor for the small G-protein Sec4p, located on cytoplasmic vesicles; essential for post-Golgi vesicle transport
YDR228C	0.259811	CAT8	YDR228C|PCF11|S000002636|mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)
YDL003W	0.259464	CAT8	YDL003W|MCD1|S000002161|Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YMR307W	0.258857	CAT8	YMR307W|GAS1|S000004924|Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YNL132W	0.258761	CAT8	YNL132W|KRE33|S000005076|Essential protein of unknown function; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
YPR091C	0.257809	CAT8	YPR091C||S000006295|Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YPR091C is not an essential gene
YKR027W	0.256978	CAT8	YKR027W|BCH2|S000001735|Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane
YPR039W	0.256589	CAT8	YPR039W||S000006243|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W
YIL076W	0.25581	CAT8	YIL076W|SEC28|S000001338|Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YFL002C	0.254865	CAT8	YFL002C|SPB4|S000001894|Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
YDR499W	0.254004	CAT8	YDR499W|LCD1|S000002907|Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP
YEL026W	0.253119	CAT8	YEL026W|SNU13|S000000752|RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
YDR309C	0.25082	CAT8	YDR309C|GIC2|S000002717|Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YER062C	0.250621	CAT8	YER062C|HOR2|S000000864|One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
YML005W	0.249677	CAT8	YML005W|TRM12|S000004464|S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YOR179C	0.249343	CAT8	YOR179C|SYC1|S000005705|Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs
YBL026W	0.244843	CAT8	YBL026W|LSM2|S000000122|Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YPR092W	0.244148	CAT8	YPR092W||S000006296|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR314W	0.242364	CAT8	YOR314W||S000005841|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR146C-A	0.24232	CAT8	YGR146C-A||S000028638|Putative protein of unknown function
YMR194C-A	0.24034	CAT8	YMR194C-A||S000007250|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR157W	0.239742	CAT8	YDR157W||S000002564|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR199W	0.239679	CAT8	YBR199W|KTR4|S000000403|Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YMR230W	0.238901	CAT8	YMR230W|RPS10B|S000004843|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10
YOL006C	0.237709	CAT8	YOL006C|TOP1|S000005366|Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination
YDR305C	0.234384	CAT8	YDR305C|HNT2|S000002713|Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins
YNL239W	0.233534	CAT8	YNL239W|LAP3|S000005183|Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
YNR012W	0.233357	CAT8	YNR012W|URK1|S000005295|Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
YGR237C	0.233207	CAT8	YGR237C||S000003469|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YDR054C	0.232877	CAT8	YDR054C|CDC34|S000002461|Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation
YDR477W	0.232684	CAT8	YDR477W|SNF1|S000002885|AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
YKL173W	0.232123	CAT8	YKL173W|SNU114|S000001656|GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2
YNL338W	0.230638	CAT8	YNL338W||S000005282|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YGL116W	0.230423	CAT8	YGL116W|CDC20|S000003084|Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate
YOL011W	0.229752	CAT8	YOL011W|PLB3|S000005371|Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro
YCL049C	0.228314	CAT8	YCL049C||S000000554|Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene;
YDL186W	0.227653	CAT8	YDL186W||S000002345|Putative protein of unknown function; YDL186W is not an essential gene
YBR055C	0.227528	CAT8	YBR055C|PRP6|S000000259|Splicing factor, component of the U4/U6-U5 snRNP complex
YLR411W	0.226588	CAT8	YLR411W|CTR3|S000004403|High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YER057C	0.22626	CAT8	YER057C|HMF1|S000000859|Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro
YPR143W	0.222257	CAT8	YPR143W|RRP15|S000006347|Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs
YHR038W	0.222185	CAT8	YHR038W|RRF1|S000001080|Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
YOR189W	0.219755	CAT8	YOR189W|IES4|S000005715|Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses
YBR283C	0.218991	CAT8	YBR283C|SSH1|S000000487|Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YER107W-A	0.217062	CAT8	YER107W-A||S000028755|Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C
YCR047W-A	0.21697	CAT8	YCR047W-A||S000028608|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YHR047C	0.215655	CAT8	YHR047C|AAP1|S000001089|Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
YER183C	0.215374	CAT8	YER183C|FAU1|S000000985|5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YER036C	0.214922	CAT8	YER036C|ARB1|S000000838|ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p
YGL169W	0.211136	CAT8	YGL169W|SUA5|S000003137|Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct start
YNL189W	0.21105	CAT8	YNL189W|SRP1|S000005133|Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YLR446W	0.210783	CAT8	YLR446W||S000004438|Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
YDR363W-A	0.209495	CAT8	YDR363W-A|SEM1|S000007235|Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1
YML030W	0.208701	CAT8	YML030W|AIM31|S000004492|Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth rate in minimal glycerol media
YNL290W	0.207525	CAT8	YNL290W|RFC3|S000005234|Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YBR177C	0.206814	CAT8	YBR177C|EHT1|S000000381|Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YER107C	0.206735	CAT8	YER107C|GLE2|S000000909|Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p
YIL011W	0.206168	CAT8	YIL011W|TIR3|S000001273|Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YHR127W	0.206087	CAT8	YHR127W||S000001169|Protein of unknown function; localizes to the nucleus
YCR104W	0.204886	CAT8	YCR104W|PAU3|S000000701|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YNR030W	0.20486	CAT8	YNR030W|ALG12|S000005313|Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
YBR253W	0.203645	CAT8	YBR253W|SRB6|S000000457|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
YOL136C	0.203127	CAT8	YOL136C|PFK27|S000005496|6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YOR313C	0.202453	CAT8	YOR313C|SPS4|S000005840|Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YGL234W	0.201543	CAT8	YGL234W|ADE5,7|S000003203|Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities
YGR161W-C	0.201325	CAT8	YGR161W-C||S000029726|Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YBR034C	0.20129	CAT8	YBR034C|HMT1|S000000238|Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, thus facilitating nuclear export of these proteins; required for viability of npl3 mutants
YER082C	0.197557	CAT8	YER082C|UTP7|S000000884|Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YHR029C	0.1961	CAT8	YHR029C|YHI9|S000001071|Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production
YLR177W	0.195936	CAT8	YLR177W||S000004167|Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene
YFL038C	0.194853	CAT8	YFL038C|YPT1|S000001856|Ras-like small GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
YMR122C	0.194213	CAT8	YMR122C||S000004729|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR295C	0.19289	CAT8	YDR295C|HDA2|S000002703|Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance
YER052C	0.191523	CAT8	YER052C|HOM3|S000000854|Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YGR091W	0.189764	CAT8	YGR091W|PRP31|S000003323|Splicing factor, component of the U4/U6-U5 snRNP complex
YER159C	0.186465	CAT8	YER159C|BUR6|S000000961|Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YFL017W-A	0.18534	CAT8	YFL017W-A|SMX2|S000002965|Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
YIL116W	0.184973	CAT8	YIL116W|HIS5|S000001378|Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YOL142W	0.182252	CAT8	YOL142W|RRP40|S000005502|Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex
YGL225W	0.181877	CAT8	YGL225W|VRG4|S000003193|Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YBR085C-A	0.180246	CAT8	YBR085C-A||S000007522|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YBR007C	0.178632	CAT8	YBR007C|DSF2|S000000211|Deletion suppressor of mpt5 mutation
YNL268W	0.178468	CAT8	YNL268W|LYP1|S000005212|Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids
YGR024C	0.176977	CAT8	YGR024C|THG1|S000003256|tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes
YDR517W	0.176726	CAT8	YDR517W|GRH1|S000002925|Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YPL019C	0.175714	CAT8	YPL019C|VTC3|S000005940|Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YLR407W	0.174624	CAT8	YLR407W||S000004399|Putative protein of unknown function; YLR407W is not an essential gene
YPL049C	0.173883	CAT8	YPL049C|DIG1|S000005970|Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YEL048C	0.171603	CAT8	YEL048C||S000000774|Putative protein of unknown function; synthetic lethal with gcs1delta
YLR191W	0.167942	CAT8	YLR191W|PEX13|S000004181|Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YGL151W	0.166672	CAT8	YGL151W|NUT1|S000003119|Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription
YFL056C	0.166187	CAT8	YFL056C|AAD6|S000001838|Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response
YPR167C	0.165423	CAT8	YPR167C|MET16|S000006371|3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism
YGL181W	0.165401	CAT8	YGL181W|GTS1|S000003149|Protein that localizes to the nucleus and is involved in transcription regulation; also localizes to actin patches and plays a role in endocytosis; N-terminus contains an ARF-GAP domain and C-terminus contains a Gln-rich domain
YBL108W	0.163554	CAT8	YBL108W||S000000204|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML054C-A	0.162124	CAT8	YML054C-A||S000028573|Putative protein of unknown function
YJR056C	0.162068	CAT8	YJR056C||S000003817|Hypothetical protein
YGL244W	0.161302	CAT8	YGL244W|RTF1|S000003213|Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance
YOR091W	0.160087	CAT8	YOR091W|TMA46|S000005617|Protein of unknown function that associates with ribosomes; interacts with GTPase Rbg1p
YBR157C	0.159976	CAT8	YBR157C|ICS2|S000000361|Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YDL126C	0.159057	CAT8	YDL126C|CDC48|S000002284|ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome
YBR027C	0.15845	CAT8	YBR027C||S000000231|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR163W	0.157972	CAT8	YGR163W|GTR2|S000003395|Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
YPR034W	0.156944	CAT8	YPR034W|ARP7|S000006238|Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YKL001C	0.156753	CAT8	YKL001C|MET14|S000001484|Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YKL165C-A	0.15635	CAT8	YKL165C-A||S000007617|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL255W	0.156272	CAT8	YPL255W|BBP1|S000006176|Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YPR185W	0.155544	CAT8	YPR185W|ATG13|S000006389|Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling
YDL173W	0.153978	CAT8	YDL173W||S000002332|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDL173W is not an essential gene
YGR291C	0.153803	CAT8	YGR291C||S000003523|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL221W	0.150055	CAT8	YPL221W|FLC1|S000006142|Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance
YNR032W	0.149867	CAT8	YNR032W|PPG1|S000005315|Putative serine/threonine protein phosphatase, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases
YJR086W	0.149863	CAT8	YJR086W|STE18|S000003846|G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling
YER126C	0.149248	CAT8	YER126C|NSA2|S000000928|Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA
YEL036C	0.14864	CAT8	YEL036C|ANP1|S000000762|Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol
YNL284C	0.148417	CAT8	YNL284C|MRPL10|S000005228|Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels
YJR094C	0.147202	CAT8	YJR094C|IME1|S000003854|Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YNR029C	0.143582	CAT8	YNR029C||S000005312|Putative protein of unknown function, deletion confers reduced fitness in saline
YMR036C	0.142246	CAT8	YMR036C|MIH1|S000004639|Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25
YDR123C	0.140192	CAT8	YDR123C|INO2|S000002530|Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion
YKL082C	0.1384	CAT8	YKL082C|RRP14|S000001565|Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
YHR032W	0.138117	CAT8	YHR032W||S000001074|Putative protein of unknown function; putative substrate of the cAMP-dependent protein kinase (PKA)
YPR014C	0.136624	CAT8	YPR014C||S000006218|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YKR073C	0.136339	CAT8	YKR073C||S000001781|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR112W	0.13582	CAT8	YLR112W||S000004102|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL021C	0.135123	CAT8	YOL021C|DIS3|S000005381|Catalytic component of the exosome, involved in RNA processing and degradation; binds Gsp1p/Ran and enhances the GEF activity of Srm1p; implicated in mitotic control; homologous to the E. coli RNase R of the RNase II family
YGR178C	0.134329	CAT8	YGR178C|PBP1|S000003410|Protein interacting with poly(A)-binding protein Pab1p; likely involved in controlling the extent of mRNA polyadenylation; forms a complex with Mkt1p that may regulate HO translation; interacts with Lsm12p in a copurification assay
YOR197W	0.133788	CAT8	YOR197W|MCA1|S000005723|Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment
YKL101W	0.132536	CAT8	YKL101W|HSL1|S000001584|Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YGL042C	0.131426	CAT8	YGL042C||S000003010|Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1
YNL241C	0.130183	CAT8	YNL241C|ZWF1|S000005185|Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia
YJL215C	0.124543	CAT8	YJL215C||S000003751|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIR006C	0.124537	CAT8	YIR006C|PAN1|S000001445|Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease
YBR142W	0.123752	CAT8	YBR142W|MAK5|S000000346|Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
YNL155W	0.12305	CAT8	YNL155W||S000005099|Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site
YHR056W-A	0.122628	CAT8	YHR056W-A||S000028777|Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR355W	0.121786	CAT8	YOR355W|GDS1|S000005882|Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER188W	0.120113	CAT8	YER188W||S000000990|Hypothetical protein
YEL022W	0.119574	CAT8	YEL022W|GEA2|S000000748|Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p
YHL034C	0.118604	CAT8	YHL034C|SBP1|S000001026|Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11
YLL031C	0.118571	CAT8	YLL031C|GPI13|S000003954|ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein
YER068W	0.117594	CAT8	YER068W|MOT2|S000000870|Component of the CCR4-NOT complex, which has multiple roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitylates subunits of the nascent polypeptide-associated complex (NAC)
YDR299W	0.117028	CAT8	YDR299W|BFR2|S000002707|Essential protein possibly involved in secretion; multicopy suppressor of sensitivity to Brefeldin A
YAR028W	0.117	CAT8	YAR028W||S000000076|Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YOR356W	0.116896	CAT8	YOR356W||S000005883|Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases
YDR241W	0.116327	CAT8	YDR241W|BUD26|S000002649|Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YML006C	0.114473	CAT8	YML006C|GIS4|S000004465|CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YIL029C	0.11309	CAT8	YIL029C||S000001291|Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YGL050W	0.113044	CAT8	YGL050W|TYW3|S000003018|tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YPR088C	0.110985	CAT8	YPR088C|SRP54|S000006292|Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
YMR044W	0.110341	CAT8	YMR044W|IOC4|S000004647|Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif
YNL186W	0.1094	CAT8	YNL186W|UBP10|S000005130|Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus
YCL007C	0.109398	CAT8	YCL007C||S000000513|Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A
YGR092W	0.108932	CAT8	YGR092W|DBF2|S000003324|Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis
YDR138W	0.108349	CAT8	YDR138W|HPR1|S000002545|Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
YNL279W	0.108305	CAT8	YNL279W|PRM1|S000005223|Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p
YMR005W	0.107583	CAT8	YMR005W|TAF4|S000004607|TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
YLR283W	0.105059	CAT8	YLR283W||S000004273|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene
YJL186W	0.104821	CAT8	YJL186W|MNN5|S000003722|Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YGR262C	0.104593	CAT8	YGR262C|BUD32|S000003494|Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p
YCR077C	0.103329	CAT8	YCR077C|PAT1|S000000673|Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p
YER058W	0.102829	CAT8	YER058W|PET117|S000000860|Protein required for assembly of cytochrome c oxidase
YMR010W	0.10122	CAT8	YMR010W||S000004612|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1
YOR196C	0.0992698	CAT8	YOR196C|LIP5|S000005722|Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase
YNR070W	0.0982549	CAT8	YNR070W||S000005353|Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR122W	0.09668	CAT8	YDR122W|KIN1|S000002529|Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
YGR189C	0.0966641	CAT8	YGR189C|CRH1|S000003421|Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YMR066W	0.0963375	CAT8	YMR066W|SOV1|S000004670|Mitochondrial protein of unknown function
YLR460C	0.0954026	CAT8	YLR460C||S000004452|Putative protein of unknown function, possibly up-regulated by iodine
YPL081W	0.0953242	CAT8	YPL081W|RPS9A|S000006002|Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YOR099W	0.0952621	CAT8	YOR099W|KTR1|S000005625|Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family
YJL076W	0.0945179	CAT8	YJL076W|NET1|S000003612|Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure
YDR349C	0.0939992	CAT8	YDR349C|YPS7|S000002757|Putative GPI-anchored aspartic protease, located in the cytoplasm and endoplasmic reticulum
YML060W	0.0913324	CAT8	YML060W|OGG1|S000004525|Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA
YBL023C	0.0909512	CAT8	YBL023C|MCM2|S000000119|Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGL178W	0.0907532	CAT8	YGL178W|MPT5|S000003146|Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
YHR140W	0.0893959	CAT8	YHR140W||S000001182|Putative integral membrane protein of unknown function
YNL032W	0.0882507	CAT8	YNL032W|SIW14|S000004977|Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
YPR122W	0.0869766	CAT8	YPR122W|AXL1|S000006326|Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells
YEL045C	0.0866782	CAT8	YEL045C||S000000771|Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YNL068C	0.0850667	CAT8	YNL068C|FKH2|S000005012|Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase
YDL006W	0.0845574	CAT8	YDL006W|PTC1|S000002164|Type 2C protein phosphatase (PP2C); inactivates the osmosensing MAPK cascade by dephosphorylating Hog1p; mutation delays mitochondrial inheritance; deletion reveals defects in precursor tRNA splicing, sporulation and cell separation
YNL291C	0.0844773	CAT8	YNL291C|MID1|S000005235|N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
YPL066W	0.0836621	CAT8	YPL066W||S000005987|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
YBR301W	0.0834168	CAT8	YBR301W|DAN3|S000000505|Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YBL016W	0.0822868	CAT8	YBL016W|FUS3|S000000112|Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
YHR073W	0.0800625	CAT8	YHR073W|OSH3|S000001115|Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability
YDR154C	0.079762	CAT8	YDR154C||S000002561|Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein
YOR267C	0.0793545	CAT8	YOR267C|HRK1|S000005793|Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis
YPL072W	0.0791714	CAT8	YPL072W|UBP16|S000005993|Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria
YML041C	0.0791689	CAT8	YML041C|VPS71|S000004505|Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YIL061C	0.0777792	CAT8	YIL061C|SNP1|S000001323|Component of U1 snRNP required for mRNA splicing via spliceosome; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein
YJR058C	0.0775123	CAT8	YJR058C|APS2|S000003819|Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex
YNL208W	0.0774214	CAT8	YNL208W||S000005152|Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi
YPL065W	0.0773286	CAT8	YPL065W|VPS28|S000005986|Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
YHR041C	0.0759413	CAT8	YHR041C|SRB2|S000001083|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
YHL038C	0.0752563	CAT8	YHL038C|CBP2|S000001030|Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
YDL037C	0.0749403	CAT8	YDL037C|BSC1|S000002195|Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression
YML097C	0.0746472	CAT8	YML097C|VPS9|S000004563|A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
YDL025C	0.0742054	CAT8	YDL025C||S000002183|Putative protein kinase, potentially phosphorylated by Cdc28p; YDL025C is not an essential gene
YNR014W	0.072347	CAT8	YNR014W||S000005297|Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YOR048C	0.070461	CAT8	YOR048C|RAT1|S000005574|Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription termination
YDR480W	0.0701393	CAT8	YDR480W|DIG2|S000002888|Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription
YFR011C	0.0700985	CAT8	YFR011C|AIM13|S000001907|Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria; null mutant displays increased frequency of mitochondrial genome loss (petite formation) and reduced growth rate in minimal glycerol media
YPL073C	0.0681779	CAT8	YPL073C||S000005994|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments
YER133W-A	0.0677062	CAT8	YER133W-A||S000028756|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YDL175C	0.0676855	CAT8	YDL175C|AIR2|S000002334|RING finger protein that interacts with the arginine methyltransferase Hmt1p; may regulate methylation of Npl3p, which modulates Npl3p function in mRNA processing and export; has similarity to Air1p
YOL020W	0.0672085	CAT8	YOL020W|TAT2|S000005380|High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance
YEL046C	0.0672013	CAT8	YEL046C|GLY1|S000000772|Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis
YDR407C	0.0658141	CAT8	YDR407C|TRS120|S000002815|One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
YOR354C	0.0657912	CAT8	YOR354C|MSC6|S000005881|Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFR052W	0.0646062	CAT8	YFR052W|RPN12|S000001948|Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p
YLL063C	0.064235	CAT8	YLL063C|AYT1|S000003986|Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis
YHR076W	0.064044	CAT8	YHR076W|PTC7|S000001118|Mitochondrially localized type 2C protein phosphatase; expression induced by growth on ethanol and by sustained osmotic stress; possible role in carbon source utilization in low oxygen environments
YNL228W	0.0638872	CAT8	YNL228W||S000005172|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1
YMR229C	0.0636325	CAT8	YMR229C|RRP5|S000004842|RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome
YML096W	0.0632971	CAT8	YML096W||S000004562|Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10
YNL137C	0.0626179	CAT8	YNL137C|NAM9|S000005081|Mitochondrial ribosomal component of the small subunit
YLR442C	0.0613775	CAT8	YLR442C|SIR3|S000004434|Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p
YPR168W	0.0600839	CAT8	YPR168W|NUT2|S000006372|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription
YBR217W	0.058517	CAT8	YBR217W|ATG12|S000000421|Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
YDL108W	0.0582862	CAT8	YDL108W|KIN28|S000002266|Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
YNL136W	0.0576274	CAT8	YNL136W|EAF7|S000005080|Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A
YMR207C	0.0568803	CAT8	YMR207C|HFA1|S000004820|Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis
YLR461W	0.0567927	CAT8	YLR461W|PAU4|S000004453|Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YJL129C	0.0557242	CAT8	YJL129C|TRK1|S000003665|Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation
YLR329W	0.0557189	CAT8	YLR329W|REC102|S000004321|Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination
YLR039C	0.0553656	CAT8	YLR039C|RIC1|S000004029|Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes
YHR179W	0.0546621	CAT8	YHR179W|OYE2|S000001222|Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YBR209W	0.0546069	CAT8	YBR209W||S000000413|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YNL135C	0.0538452	CAT8	YNL135C|FPR1|S000005079|Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function
YGR134W	0.0513864	CAT8	YGR134W|CAF130|S000003366|Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation
YMR062C	0.0486321	CAT8	YMR062C|ECM40|S000004666|Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YCR081C-A	0.0477853	CAT8	YCR081C-A||S000028609|Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
YOR118W	0.0476995	CAT8	YOR118W|RTC5|S000005644|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity
YDL024C	0.0466657	CAT8	YDL024C|DIA3|S000002182|Protein of unknown function, involved in invasive and pseudohyphal growth
YBR026C	0.0461628	CAT8	YBR026C|ETR1|S000000230|2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis
YGR231C	0.044714	CAT8	YGR231C|PHB2|S000003463|Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation
YDR195W	0.0446977	CAT8	YDR195W|REF2|S000002603|RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes
YIL002C	0.0446639	CAT8	YIL002C|INP51|S000001264|Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth
YOL152W	0.0425154	CAT8	YOL152W|FRE7|S000005512|Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
YMR141W-A	0.0383677	CAT8	YMR141W-A||S000028575|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C
YPR149W	0.0373146	CAT8	YPR149W|NCE102|S000006353|Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs)
YEL069C	0.0357428	CAT8	YEL069C|HXT13|S000000795|Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose
YIL145C	0.0346607	CAT8	YIL145C|PAN6|S000001407|Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
YOR002W	0.0346528	CAT8	YOR002W|ALG6|S000005528|Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
YKL002W	0.0346091	CAT8	YKL002W|DID4|S000001485|Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis
YFL039C	0.0335095	CAT8	YFL039C|ACT1|S000001855|Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions
YKL053W	0.033352	CAT8	YKL053W||S000001536|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1
YNL041C	0.0315043	CAT8	YNL041C|COG6|S000004986|Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDR066C	0.0291712	CAT8	YDR066C|RTR2|S000002473|Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene
YKL045W	0.0290775	CAT8	YKL045W|PRI2|S000001528|Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
YER037W	0.0290493	CAT8	YER037W|PHM8|S000000839|Protein of unknown function, expression is induced by low phosphate levels and by inactivation of Pho85p
YDL188C	0.0282403	CAT8	YDL188C|PPH22|S000002347|Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YMR316C-A	0.0275675	CAT8	YMR316C-A||S000004933|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene DIA1/YMR316W
YLR380W	0.0271745	CAT8	YLR380W|CSR1|S000004372|Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance
YHR014W	0.0260865	CAT8	YHR014W|SPO13|S000001056|Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II
YDL034W	0.0258382	CAT8	YDL034W||S000002192|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene
YLR443W	0.0249986	CAT8	YLR443W|ECM7|S000004435|Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency
YIR023C-A	0.0247955	CAT8	YIR023C-A||S000028801|Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR082C	0.0237756	CAT8	YLR082C|SRL2|S000004072|Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
YJL134W	0.0235286	CAT8	YJL134W|LCB3|S000003670|Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids
YIL028W	0.0227991	CAT8	YIL028W||S000001290|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL218W	0.0226359	CAT8	YNL218W|MGS1|S000005162|Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP)
YGR196C	0.0220654	CAT8	YGR196C|FYV8|S000003428|Protein of unknown function, required for survival upon exposure to K1 killer toxin
YBR024W	0.0216006	CAT8	YBR024W|SCO2|S000000228|Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p
YGL190C	0.0215047	CAT8	YGL190C|CDC55|S000003158|Non-essential regulatory subunit B of protein phosphatase 2A, which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at the bud neck and at the bud tip
YER127W	0.0197952	CAT8	YER127W|LCP5|S000000929|Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
YDL161W	0.019192	CAT8	YDL161W|ENT1|S000002320|Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus
YNL042W-B	0.018199	CAT8	YNL042W-B||S000028850|Putative protein of unknown function
YDL217C	0.0171885	CAT8	YDL217C|TIM22|S000002376|Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane
YLR027C	0.016694	CAT8	YLR027C|AAT2|S000004017|Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
YGL025C	0.0164294	CAT8	YGL025C|PGD1|S000002993|Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
YML099W-A	0.0161698	CAT8	YML099W-A||S000004567|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C
YCR015C	0.0160641	CAT8	YCR015C||S000000608|Putative protein of unknown function; YCR015C is not an essential gene
YGR111W	0.0132845	CAT8	YGR111W||S000003343|Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YLR010C	0.0128937	CAT8	YLR010C|TEN1|S000004000|Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YOR144C	0.0120135	CAT8	YOR144C|ELG1|S000005670|Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair
YFR013W	0.0114788	CAT8	YFR013W|IOC3|S000001909|Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing
YML130C	0.0108767	CAT8	YML130C|ERO1|S000004599|Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
YMR019W	0.0108666	CAT8	YMR019W|STB4|S000004621|Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins
YKR052C	0.0104555	CAT8	YKR052C|MRS4|S000001760|Mitochondrial iron transporter of the mitochondrial carrier family (MCF), very similar to and functionally redundant with Mrs3p; functions under low-iron conditions; may transport other cations in addition to iron
YCL073C	0.00964324	CAT8	YCL073C||S000000575|Protein of unconfirmed function; displays a topology characteristic of the Major Facilitators Superfamily of membrane proteins; coding sequence 98% identical to that of YKR106W
YCR027C	0.00911861	CAT8	YCR027C|RHB1|S000000622|Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
YKR004C	0.00902491	CAT8	YKR004C|ECM9|S000001712|Non-essential protein of unknown function
YPL153C	0.00896045	CAT8	YPL153C|RAD53|S000006074|Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
YJL172W	0.00880605	CAT8	YJL172W|CPS1|S000003708|Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YML094C-A	0.00741861	CAT8	YML094C-A||S000004561|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
YBR216C	0.00628479	CAT8	YBR216C|YBP1|S000000420|Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress
YBR053C	0.00624263	CAT8	YBR053C||S000000257|Putative protein of unknown function; induced by cell wall perturbation
YIL050W	0.00600884	CAT8	YIL050W|PCL7|S000001312|Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YML122C	0.00566643	CAT8	YML122C||S000004591|Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR017C	0.00468256	CAT8	YPR017C|DSS4|S000006221|Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YNL221C	0.00264083	CAT8	YNL221C|POP1|S000005165|Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in RNase P
YNL160W	0.00143511	CAT8	YNL160W|YGP1|S000005104|Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YPL016W	0.000464956	CAT8	YPL016W|SWI1|S000005937|Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can become prion [SWI+]
