Results for YRM1
Z-value: 0.78
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Transcription factors associated with YRM1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
YRM1
|
S000005698 | Zinc-finger transcription factor involved in multidrug resistance |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 16.63 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 15.15 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YHR094C Show fit | 10.95 |
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting |
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| YER131W Show fit | 9.90 |
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein |
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| YKR075C Show fit | 8.57 |
Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
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| YDR033W Show fit | 7.69 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YMR102C Show fit | 7.56 |
Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene |
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| YDR345C Show fit | 7.24 |
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions |
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| YDR044W Show fit | 7.00 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
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| YLR154C Show fit | 6.77 |
Ribonuclease H2 subunit, required for RNase H2 activity |
Network of associatons between targets according to the STRING database.
First level regulatory network of YRM1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 57.4 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.1 | 20.4 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 5.5 | 16.5 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 1.7 | 12.0 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 9.1 | GO:0006364 | rRNA processing(GO:0006364) |
| 2.0 | 7.9 | GO:0046500 | S-adenosylmethionine metabolic process(GO:0046500) |
| 1.3 | 7.7 | GO:0046037 | GMP metabolic process(GO:0046037) |
| 1.1 | 7.4 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.7 | 6.6 | GO:0006116 | NADH oxidation(GO:0006116) |
| 0.3 | 6.1 | GO:0044108 | ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 52.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.2 | 33.7 | GO:0005933 | cellular bud(GO:0005933) |
| 0.5 | 30.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 13.0 | GO:0005730 | nucleolus(GO:0005730) |
| 3.9 | 11.7 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.6 | 8.7 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 0.1 | 5.4 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.0 | 5.4 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.1 | 5.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 4.8 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 77.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 14.0 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.3 | 13.9 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 2.9 | 11.7 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.3 | 10.0 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.6 | 8.7 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.5 | 7.8 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 1.7 | 7.0 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 1.1 | 6.4 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.3 | 6.3 | GO:0030515 | snoRNA binding(GO:0030515) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 0.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 0.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 0.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 0.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.8 | 6.2 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 1.0 | 3.1 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 1.1 | 2.2 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.5 | 2.0 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.2 | 1.8 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 0.4 | 1.6 | REACTOME POL SWITCHING | Genes involved in Polymerase switching |
| 0.3 | 0.9 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.3 | 0.9 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.1 | 0.9 | REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | Genes involved in Metabolism of lipids and lipoproteins |