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Results for YPR022C

Z-value: 2.04

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Transcription factors associated with YPR022C

Gene Symbol Gene ID Gene Info
S000006226 Putative transcription factor, as suggested by computational analysis

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YPR022C0.758.6e-06Click!

Activity profile of YPR022C motif

Sorted Z-values of YPR022C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YHR217C 34.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YFL063W 23.12 Dubious open reading frame, based on available experimental and comparative sequence data
YKL217W 22.80
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YHR218W 22.00 Helicase-like protein encoded within the telomeric Y' element
YFL064C 18.78 Putative protein of unknown function
YBR117C 18.10
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YFL052W 17.23 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YGR067C 14.82 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YDR536W 14.77
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YNL337W 14.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL133C-A 14.69 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL057C 14.12 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YFL062W 13.77
COS4
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YKR097W 13.57
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YPR030W 13.44
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YMR107W 13.36
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLR327C 13.32
TMA10
Protein of unknown function that associates with ribosomes
YNL339C 13.29
YRF1-6
Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p
YLR023C 13.23
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YNL336W 13.22
COS1
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YPR184W 12.72
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YHR096C 12.02
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YGL062W 11.72
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YFR053C 11.68
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YDR342C 11.48
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YOR343C 11.27 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOR235W 11.24
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YNR073C 10.36 Putative mannitol dehydrogenase
YAR053W 10.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR296C 10.04
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YHR212C 9.90 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR277C 9.62
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YER065C 9.59
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YGR144W 9.28
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YHR212W-A 9.24 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLR377C 9.18
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YMR081C 8.88
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YFR017C 8.54 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YMR017W 8.48
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YML089C 8.41 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YNL144C 8.25 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YNL194C 8.24 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YHR092C 8.22
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YAR050W 7.97
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YOR382W 7.96
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YEL070W 7.95
DSF1
Deletion suppressor of mpt5 mutation
YAR060C 7.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL008W 7.78 Hypothetical protein predicted to be involved in metabolism
YDR343C 7.36
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YGL191W 7.13
COX13
Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP
YKL026C 7.09
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YBR230C 6.96
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YEL009C 6.94
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YFL051C 6.85 Putative protein of unknown function; YFL051C is not an essential gene
YEL039C 6.72
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YAR047C 6.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR035W 6.56
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YOR376W 6.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YNL142W 6.45
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YKL109W 6.44
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YBR051W 6.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YDL174C 6.16
DLD1
D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
YBR050C 6.04
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YOR178C 6.02
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YHR138C 6.02 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YPR013C 5.99 Putative zinc finger protein; YPR013C is not an essential gene
YJL116C 5.97
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YIL162W 5.89
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YHR033W 5.74 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YFL011W 5.72
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YPR151C 5.69
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YBR250W 5.63
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YGL033W 5.60
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YDL130W-A 5.56
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YPL186C 5.53
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YCL025C 5.49
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YIL045W 5.46
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YER103W 5.40
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YEL011W 5.39
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YML133C 5.38 Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron
YIL055C 5.33 Putative protein of unknown function
YPR160W 5.30
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YGR045C 5.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL031W 5.28 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YBR105C 5.25
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YML090W 5.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YMR013C 5.11
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YLR438W 5.10
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YKR034W 5.05
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YGR289C 5.01
MAL11
Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; broad substrate specificity that includes maltotriose
YGL146C 4.95 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YJR115W 4.95 Putative protein of unknown function
YAL039C 4.89
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YGL163C 4.88
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YPL185W 4.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YCL001W-B 4.81 Putative protein of unknown function; identified by homology
YIL136W 4.81
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YGR087C 4.74
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YLR279W 4.71 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR174W 4.70
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YDR186C 4.60 Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YEL069C 4.60
HXT13
Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose
YFL030W 4.60
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YDR259C 4.48
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YOL084W 4.48
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YPL250C 4.46
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YGR032W 4.43
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YLR437C-A 4.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YDR043C 4.41
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YBR033W 4.40
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YLR294C 4.38 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14
YML132W 4.36
COS3
Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGR290W 4.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
YOL060C 4.30
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YGR243W 4.23
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL079C 4.17
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YHR126C 4.12 Putative protein of unknown function; transcription dependent upon Azf1p
YLR149C 4.11 Putative protein of unknown function; YLR149C is not an essential gene
YNL143C 4.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR292C 4.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YML091C 4.10
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YOR394W 4.08
PAU21
Hypothetical protein
YPR036W-A 4.04 Protein of unknown function; transcription is regulated by Pdr1p
YMR280C 4.04
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YDR096W 4.04
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YDL169C 3.97
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YBL030C 3.92
PET9
Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; required for viability in many common lab strains carrying a mutation in the polymorphic SAL1 gene
YIL107C 3.88
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YMR165C 3.87
PAH1
Mg2+-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol and Pi, responsible for de novo lipid synthesis; homologous to mammalian lipin 1
YPL024W 3.85
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YMR194C-B 3.81 Putative protein of unknown function
YMR182C 3.80
RGM1
Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth
YPL230W 3.80
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YGR292W 3.79
MAL12
Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus
YHR048W 3.76
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YML120C 3.75
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YOR236W 3.71
DFR1
Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
YKL085W 3.65
MDH1
Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated
YOR065W 3.58
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YOL047C 3.53 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER187W 3.52 Putative protein of unknown function; induced in respiratory-deficient cells
YLR278C 3.51 Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene
YKR102W 3.48
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YAR069C 3.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR250W 3.46
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YKL044W 3.44 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJR159W 3.40
SOR1
Sorbitol dehydrogenase; expression is induced in the presence of sorbitol
YKL171W 3.39 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YHR211W 3.39
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YBR203W 3.38
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR288W 3.36
MAL13
MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YBL033C 3.33
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YOR173W 3.32
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YML042W 3.29
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YCR025C 3.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YBR230W-A 3.27 Putative protein of unknown function
YGL180W 3.14
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YML054C 3.13
CYB2
Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions
YPL026C 3.12
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YHL032C 3.11
GUT1
Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YLR307C-A 3.09 Putative protein of unknown function
YMR118C 3.08 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YEL007W 3.04 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YPR106W 3.02
ISR1
Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C
YHR071W 3.02
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YGR065C 3.01
VHT1
High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YNL074C 3.01
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YFR015C 3.00
GSY1
Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase
YFL054C 2.98 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YOR192C 2.90
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YKL163W 2.90
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YDL234C 2.90
GYP7
GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking
YOR192C-C 2.88 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YOR383C 2.88
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YHR095W 2.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR070C 2.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL274C 2.83
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHR145C 2.82 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR088W 2.81
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YNR002C 2.81
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBR255C-A 2.79 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YPR192W 2.78
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YMR316C-B 2.77 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR268C 2.76 Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene
YOR374W 2.75
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YJL135W 2.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
YPL061W 2.72
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YPL054W 2.72
LEE1
Zinc-finger protein of unknown function
YPL282C 2.70
PAU22
Hypothetical protein
YIL099W 2.69
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YDR281C 2.68
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YMR317W 2.65 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YEL074W 2.61 Hypothetical protein
YDL223C 2.56
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YER066W 2.55 Putative protein of unknown function; YER066W is not an essential gene
YER167W 2.54
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YLR004C 2.52
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YER188C-A 2.49 Putative protein of unknown function
YCR021C 2.49
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YMR014W 2.48
BUD22
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern

Network of associatons between targets according to the STRING database.

First level regulatory network of YPR022C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 25.3 GO:0006848 pyruvate transport(GO:0006848)
4.1 20.7 GO:0005980 glycogen catabolic process(GO:0005980)
3.3 9.8 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
3.1 9.4 GO:0015755 fructose transport(GO:0015755)
2.9 8.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.9 14.5 GO:0015793 glycerol transport(GO:0015793)
2.8 8.5 GO:0006545 glycine biosynthetic process(GO:0006545)
2.3 7.0 GO:0072488 ammonium transmembrane transport(GO:0072488)
2.3 15.8 GO:0000023 maltose metabolic process(GO:0000023)
2.2 21.9 GO:0046487 glyoxylate metabolic process(GO:0046487)
2.1 12.7 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.0 6.0 GO:0006740 NADPH regeneration(GO:0006740)
1.9 7.6 GO:0006527 arginine catabolic process(GO:0006527)
1.9 5.6 GO:0042128 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
1.8 9.2 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
1.7 5.2 GO:0051469 vesicle fusion with vacuole(GO:0051469)
1.6 14.7 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.6 4.9 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.6 1.6 GO:0042819 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.5 31.9 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
1.5 4.5 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
1.4 11.3 GO:0015891 siderophore transport(GO:0015891)
1.4 19.8 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
1.4 14.1 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
1.4 4.2 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.4 5.5 GO:0032079 positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
1.4 23.1 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.3 5.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
1.3 4.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
1.3 3.9 GO:0006538 glutamate catabolic process(GO:0006538)
1.3 3.9 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
1.3 5.1 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.3 5.1 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
1.2 4.9 GO:0015886 heme transport(GO:0015886)
1.2 3.7 GO:0006108 malate metabolic process(GO:0006108)
1.2 32.2 GO:0006094 gluconeogenesis(GO:0006094)
1.2 11.8 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.1 4.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
1.1 4.3 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
1.0 13.6 GO:0000722 telomere maintenance via recombination(GO:0000722)
1.0 5.9 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
1.0 2.9 GO:0015888 thiamine transport(GO:0015888)
0.9 1.8 GO:2000219 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.9 2.7 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.9 11.8 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.9 0.9 GO:0046471 phosphatidylglycerol metabolic process(GO:0046471)
0.8 0.8 GO:0006559 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.8 1.7 GO:0000304 response to singlet oxygen(GO:0000304)
0.8 3.3 GO:0034389 lipid particle organization(GO:0034389)
0.8 6.4 GO:0031647 regulation of protein stability(GO:0031647)
0.8 2.3 GO:0006000 fructose metabolic process(GO:0006000)
0.7 0.7 GO:0032075 regulation of nuclease activity(GO:0032069) positive regulation of nuclease activity(GO:0032075)
0.7 0.7 GO:0046185 aldehyde catabolic process(GO:0046185)
0.7 5.0 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.7 2.8 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.7 2.1 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.7 1.4 GO:0071941 nitrogen cycle metabolic process(GO:0071941)
0.7 2.0 GO:0015847 putrescine transport(GO:0015847)
0.7 4.0 GO:0006089 lactate metabolic process(GO:0006089)
0.7 2.6 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
0.6 0.6 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.6 1.7 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.6 0.6 GO:0009190 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.6 9.4 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.5 9.7 GO:0007129 synapsis(GO:0007129)
0.5 1.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.5 26.5 GO:0009060 aerobic respiration(GO:0009060)
0.5 2.6 GO:0051180 vitamin transport(GO:0051180)
0.5 2.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.5 1.0 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.5 2.0 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.5 5.0 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.5 1.4 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.5 1.4 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.5 6.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 2.3 GO:0032048 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048)
0.4 1.3 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.4 0.4 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.4 2.7 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.4 10.5 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 0.4 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.4 3.9 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.4 1.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.4 2.5 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.4 5.9 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.4 1.9 GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238)
0.4 3.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.4 2.2 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.4 1.5 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.4 1.1 GO:0019748 secondary metabolic process(GO:0019748)
0.3 1.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.3 1.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 1.0 GO:0071456 cellular response to hypoxia(GO:0071456)
0.3 3.7 GO:0015893 drug transport(GO:0015893)
0.3 0.7 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.3 1.0 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.3 2.3 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.3 1.3 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.3 0.9 GO:0006598 polyamine catabolic process(GO:0006598)
0.3 2.5 GO:0019740 nitrogen utilization(GO:0019740)
0.3 1.5 GO:0006021 inositol biosynthetic process(GO:0006021)
0.3 2.7 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.3 1.6 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.3 8.2 GO:0098660 inorganic ion transmembrane transport(GO:0098660)
0.3 0.3 GO:0042743 hydrogen peroxide metabolic process(GO:0042743)
0.3 1.1 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.3 2.3 GO:0070987 error-free translesion synthesis(GO:0070987)
0.2 1.7 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 1.0 GO:0071322 cellular response to carbohydrate stimulus(GO:0071322)
0.2 1.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.2 5.2 GO:0016579 protein deubiquitination(GO:0016579)
0.2 0.2 GO:0070726 cell wall assembly(GO:0070726)
0.2 1.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.2 0.5 GO:0015680 intracellular copper ion transport(GO:0015680)
0.2 2.6 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.2 0.7 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.2 0.5 GO:0015691 cadmium ion transport(GO:0015691)
0.2 1.9 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 0.6 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.2 0.6 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.2 3.1 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 1.1 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.2 0.7 GO:0032973 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.2 0.9 GO:0055088 lipid homeostasis(GO:0055088)
0.2 1.6 GO:0042766 nucleosome mobilization(GO:0042766)
0.2 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.2 1.7 GO:0015802 basic amino acid transport(GO:0015802)
0.2 0.6 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.2 1.4 GO:0006826 iron ion transport(GO:0006826)
0.1 0.7 GO:0044070 regulation of anion transport(GO:0044070)
0.1 1.1 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.7 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.3 GO:0051098 regulation of binding(GO:0051098)
0.1 1.1 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.3 GO:0009310 tryptophan catabolic process(GO:0006569) amine catabolic process(GO:0009310) cellular biogenic amine catabolic process(GO:0042402) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.1 7.4 GO:0007031 peroxisome organization(GO:0007031)
0.1 1.1 GO:0000103 sulfate assimilation(GO:0000103)
0.1 2.1 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.6 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.5 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.4 GO:0031297 replication fork processing(GO:0031297)
0.1 0.1 GO:0045913 positive regulation of cellular carbohydrate metabolic process(GO:0010676) positive regulation of carbohydrate metabolic process(GO:0045913)
0.1 0.2 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 0.4 GO:0031555 transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.1 0.6 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 0.4 GO:0097271 protein localization to bud neck(GO:0097271)
0.1 0.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.8 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546)
0.1 0.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 1.0 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 0.4 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.1 0.5 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.1 0.4 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 0.7 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 1.7 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 0.2 GO:0006739 NADP metabolic process(GO:0006739)
0.1 0.6 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.1 0.2 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.1 0.3 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.1 0.4 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.1 0.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.1 0.2 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.6 GO:0090054 regulation of chromatin silencing at silent mating-type cassette(GO:0090054)
0.1 0.4 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 2.3 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 2.4 GO:0042176 regulation of protein catabolic process(GO:0042176)
0.1 0.2 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.1 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.1 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.7 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.4 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.1 GO:0015851 nucleobase transport(GO:0015851)
0.1 0.3 GO:0018065 protein-cofactor linkage(GO:0018065)
0.1 0.4 GO:0070058 tRNA gene clustering(GO:0070058)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.6 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.1 GO:0001304 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.0 0.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.0 0.1 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.0 0.7 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.2 GO:0051304 chromosome separation(GO:0051304)
0.0 0.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.0 0.3 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.4 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.3 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.4 GO:0051293 establishment of spindle localization(GO:0051293) spindle localization(GO:0051653)
0.0 0.1 GO:0034501 inositol phosphate biosynthetic process(GO:0032958) protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.1 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.0 0.9 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.2 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.2 GO:0006818 hydrogen transport(GO:0006818)
0.0 0.2 GO:0043461 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.1 GO:0017004 cytochrome complex assembly(GO:0017004)
0.0 0.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.0 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 1.8 GO:0048646 sporulation resulting in formation of a cellular spore(GO:0030435) anatomical structure formation involved in morphogenesis(GO:0048646)
0.0 0.2 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.1 GO:0010525 regulation of transposition, RNA-mediated(GO:0010525)
0.0 0.1 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.0 0.1 GO:0023058 adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion(GO:0000754) adaptation of signaling pathway(GO:0023058)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
1.7 6.6 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.6 13.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.3 3.8 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.1 4.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
1.1 3.2 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
1.0 3.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.9 7.5 GO:0042597 periplasmic space(GO:0042597)
0.9 24.7 GO:0070469 respiratory chain(GO:0070469)
0.9 6.1 GO:0034657 GID complex(GO:0034657)
0.8 14.0 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.8 2.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 8.9 GO:0045259 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.5 1.6 GO:0005796 Golgi lumen(GO:0005796)
0.5 1.8 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.4 1.6 GO:0031901 early endosome membrane(GO:0031901)
0.3 0.7 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.3 1.7 GO:0031932 TORC2 complex(GO:0031932)
0.3 6.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 1.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.3 1.3 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 1.0 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 5.9 GO:0031201 SNARE complex(GO:0031201)
0.2 0.7 GO:0030870 Mre11 complex(GO:0030870)
0.2 0.6 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 1.7 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 0.8 GO:0000817 COMA complex(GO:0000817)
0.2 5.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 9.7 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.4 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 28.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.2 1.3 GO:0016459 myosin complex(GO:0016459)
0.2 0.3 GO:0032389 MutLalpha complex(GO:0032389)
0.2 27.5 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 4.8 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 0.7 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.8 GO:0005769 early endosome(GO:0005769)
0.1 0.4 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 83.8 GO:0005739 mitochondrion(GO:0005739)
0.1 1.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 0.5 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 1.2 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.5 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.7 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 2.0 GO:0016592 mediator complex(GO:0016592)
0.1 0.3 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.2 GO:0070209 ASTRA complex(GO:0070209)
0.1 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.7 GO:0000812 Swr1 complex(GO:0000812) INO80-type complex(GO:0097346)
0.1 0.4 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.7 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.1 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.8 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.3 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.4 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.1 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.3 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 0.1 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 5.7 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 44.0 GO:0015295 solute:proton symporter activity(GO:0015295)
3.7 22.4 GO:0090599 alpha-glucosidase activity(GO:0090599)
3.7 14.8 GO:0005537 mannose binding(GO:0005537)
3.3 9.8 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.9 17.5 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
2.9 14.3 GO:0015294 solute:cation symporter activity(GO:0015294)
2.5 10.0 GO:0004396 hexokinase activity(GO:0004396)
2.4 7.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
2.4 9.4 GO:0016898 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
2.3 11.5 GO:0050308 sugar-phosphatase activity(GO:0050308)
1.9 9.3 GO:0008198 ferrous iron binding(GO:0008198)
1.8 1.8 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.7 6.6 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
1.6 4.7 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.5 4.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.5 17.5 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.4 4.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.4 1.4 GO:0004075 biotin carboxylase activity(GO:0004075)
1.3 5.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
1.3 9.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.3 4.0 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.2 3.7 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.2 16.7 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
1.2 17.3 GO:0016831 carboxy-lyase activity(GO:0016831)
1.1 6.7 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.1 14.3 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
1.1 4.3 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
1.1 2.1 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
1.1 6.3 GO:0015293 symporter activity(GO:0015293)
1.0 3.9 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.8 2.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.8 2.3 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.8 2.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.7 2.8 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.7 11.0 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.7 6.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.7 2.0 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.6 2.6 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.6 3.8 GO:0000400 four-way junction DNA binding(GO:0000400)
0.6 1.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 6.6 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.6 1.7 GO:0016208 AMP binding(GO:0016208)
0.6 2.2 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 6.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 5.3 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.5 1.6 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.5 7.6 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.5 1.5 GO:0015927 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 0.5 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.5 2.4 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.5 2.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.4 2.6 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.4 3.0 GO:0019238 cyclohydrolase activity(GO:0019238)
0.4 7.6 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.4 3.3 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 1.6 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.4 1.9 GO:0016783 sulfurtransferase activity(GO:0016783)
0.4 4.2 GO:0015297 antiporter activity(GO:0015297)
0.4 1.1 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.4 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 1.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.4 3.2 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.3 0.7 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.3 4.2 GO:0022838 substrate-specific channel activity(GO:0022838)
0.3 1.0 GO:0004629 phospholipase C activity(GO:0004629)
0.3 1.7 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 1.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.3 5.3 GO:0015616 DNA translocase activity(GO:0015616)
0.3 1.9 GO:0030145 manganese ion binding(GO:0030145)
0.3 10.3 GO:0003678 DNA helicase activity(GO:0003678)
0.3 1.4 GO:0016530 metallochaperone activity(GO:0016530)
0.3 1.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.3 5.1 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 2.2 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 1.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 1.3 GO:0000146 microfilament motor activity(GO:0000146)
0.3 7.7 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.2 1.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 5.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 0.7 GO:0097027 cyclin binding(GO:0030332) ubiquitin-protein transferase activator activity(GO:0097027)
0.2 0.7 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.2 0.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.2 0.2 GO:0015288 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.2 0.7 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.2 0.7 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 1.7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.2 1.7 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 3.7 GO:0050661 NADP binding(GO:0050661)
0.2 1.8 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 4.2 GO:0003684 damaged DNA binding(GO:0003684)
0.2 1.4 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.2 1.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.2 0.2 GO:0032451 demethylase activity(GO:0032451)
0.2 0.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.2 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.6 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.2 0.3 GO:0031072 heat shock protein binding(GO:0031072)
0.2 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 2.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 2.8 GO:0051087 chaperone binding(GO:0051087)
0.1 0.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 0.3 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 1.6 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.9 GO:0030246 carbohydrate binding(GO:0030246)
0.1 14.6 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 2.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 0.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.4 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.1 1.1 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.3 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.1 0.8 GO:0010181 FMN binding(GO:0010181)
0.1 1.0 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.6 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 1.8 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.7 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 0.2 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 1.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.6 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.3 GO:0008169 C-methyltransferase activity(GO:0008169)
0.1 0.2 GO:0032183 SUMO binding(GO:0032183)
0.1 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.4 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.1 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.0 0.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.4 GO:0004888 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.0 0.1 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.0 0.8 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 5.0 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.0 0.3 GO:0005507 copper ion binding(GO:0005507)
0.0 0.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.5 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 1.8 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.0 0.1 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.0 1.6 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 0.4 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.1 GO:0001099 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0031386 protein tag(GO:0031386)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.0 15.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.1 4.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.5 4.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.5 1.6 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.4 1.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.4 0.7 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.2 0.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.2 0.4 PID AP1 PATHWAY AP-1 transcription factor network
0.2 247.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.2 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID P73PATHWAY p73 transcription factor network
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 26.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.4 4.2 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
1.1 2.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
1.0 2.0 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.8 2.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.5 1.5 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.4 1.1 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.3 0.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 0.8 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 1.2 REACTOME MEIOSIS Genes involved in Meiosis
0.2 240.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.4 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.1 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 0.9 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.3 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.1 0.2 REACTOME HEMOSTASIS Genes involved in Hemostasis
0.1 0.4 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 0.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME TRANSCRIPTION Genes involved in Transcription