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Results for YML081W

Z-value: 0.47

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Transcription factors associated with YML081W

Gene Symbol Gene ID Gene Info
TDA9
S000004546 DNA-binding protein, putative transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
YML081W-0.563.0e-03Click!

Activity profile of YML081W motif

Sorted Z-values of YML081W motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 8.50
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 7.81 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YKR075C 4.50 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YGR242W 4.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YDR041W 4.02
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YOR101W 3.81
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YDR033W 3.78
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YMR290W-A 3.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGR241C 3.45
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YMR290C 3.45
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDR040C 3.13
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YOL086C 2.95
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YDR279W 2.77
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YGR108W 2.74
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGL209W 2.71
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YMR011W 2.65
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YLR110C 2.57
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YKL218C 2.46
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YLR328W 2.37
NMA1
Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways
YDL022C-A 2.18 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YBR158W 2.16
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YOR376W-A 2.15 Putative protein of unknown function; identified by fungal homology and RT-PCR
YCR004C 2.15
YCP4
Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR094W 2.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YBR032W 2.08 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YDR509W 2.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNR013C 2.05
PHO91
Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YLR150W 2.05
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YDR344C 2.04 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR508C 2.02
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YHR094C 1.96
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YGR138C 1.90
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YDR095C 1.85 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR044W 1.85
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YDR497C 1.80
ITR1
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p
YFR054C 1.75 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL045C 1.75
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YOR375C 1.74
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YKL164C 1.70
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YPR029C 1.68
APL4
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YDR133C 1.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YOR063W 1.60
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YKL063C 1.59 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YFL015C 1.55 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YFL015W-A 1.53 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL068C 1.46 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR083W 1.44
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YKL110C 1.40
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YLR154C 1.40
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YDR399W 1.39
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YIR021W 1.37
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YPL265W 1.35
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YNR072W 1.33
HXT17
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YMR194C-A 1.33 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL085C 1.33 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YDL085C-A 1.33 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR140W 1.30
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YMR281W 1.27
GPI12
ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp
YNL028W 1.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR032W 1.25
HOF1
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YHR181W 1.23
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YBR210W 1.23
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YDL023C 1.21 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YIL053W 1.19
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YER124C 1.18
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YGR086C 1.18
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YNL029C 1.17
KTR5
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YEL066W 1.16
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YPL263C 1.12
KEL3
Cytoplasmic protein of unknown function
YDL047W 1.10
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YBL032W 1.10
HEK2
RNA binding protein with similarity to hnRNP-K that localizes to the cytoplasm and to subtelomeric DNA; required for the proper localization of ASH1 mRNA; involved in the regulation of telomere position effect and telomere length
YLR089C 1.07
ALT1
Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR119W 1.07
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGL179C 1.06
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YER134C 1.05 Putative protein of unknown function; non-essential gene
YPL075W 1.04
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YDR098C 1.02
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YBR106W 1.02
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YLR413W 1.02 Putative protein of unknown function; YLR413W is not an essential gene
YGR139W 1.02 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL056W 1.01
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YHR201C 1.00
PPX1
Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YJL212C 1.00
OPT1
Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YJL029C 0.99
VPS53
Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YOR029W 0.99 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YJR114W 0.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C
YDR088C 0.96
SLU7
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YDR534C 0.96
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YOR028C 0.96
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YMR102C 0.95 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YMR318C 0.95
ADH6
NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
YEL067C 0.94 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR001W-A 0.93 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YJR113C 0.93
RSM7
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein
YNR014W 0.93 Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YLR349W 0.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YLR348C 0.92
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YDL022W 0.91
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YLR437C 0.91 Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YGR180C 0.90
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YER136W 0.90
GDI1
GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YKR092C 0.89
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YLR154W-B 0.89 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YPL003W 0.89
ULA1
Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
YOR021C 0.88 Putative protein of unknown function; YOR021C is not an essential gene
YIL111W 0.88
COX5B
Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
YLR154W-A 0.88 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YER056C-A 0.87
RPL34A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein
YKL219W 0.86
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YOR276W 0.86
CAF20
Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
YLR109W 0.86
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YNL069C 0.85
RPL16B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YBL077W 0.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YMR106C 0.84
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YKL096W 0.84
CWP1
Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YKL209C 0.83
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YNR016C 0.83
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YHR162W 0.82 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YGR181W 0.82
TIM13
Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YBR254C 0.81
TRS20
One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder
YOR025W 0.80
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YHR021C 0.80
RPS27B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein
YPR050C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
YJR094W-A 0.79
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YPR010C 0.79
RPA135
RNA polymerase I subunit A135
YIL118W 0.79
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YKL182W 0.79
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YOL130W 0.78
ALR1
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YHR180W-A 0.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YGR106C 0.77
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YDR072C 0.77
IPT1
Inositolphosphotransferase 1, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), which is the most abundant sphingolipid in cells, mutation confers resistance to the antifungals syringomycin E and DmAMP1 in some growth media
YOR143C 0.76
THI80
Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YPL004C 0.73
LSP1
Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YDR278C 0.73 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR074W 0.72
TPS2
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YHR149C 0.72
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YMR183C 0.71
SSO2
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YLR333C 0.71
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YIL052C 0.71
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YOR272W 0.70
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YKL096W-A 0.69
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YOR263C 0.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W
YKR099W 0.69
BAS1
Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
YJL107C 0.68 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YML106W 0.68
URA5
Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10
YJL200C 0.68
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YOR369C 0.68
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YNL066W 0.68
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YPL037C 0.67
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YOR277C 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YNL234W 0.67 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YKL181W 0.66
PRS1
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YGR264C 0.66
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YCR018C 0.66
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YKR026C 0.66
GCN3
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YML074C 0.65
FPR3
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YML005W 0.64
TRM12
S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA
YFL016C 0.64
MDJ1
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YGR265W 0.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YGR107W 0.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR126W-A 0.63 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YIL009W 0.62
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YOL136C 0.62
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YOR327C 0.62
SNC2
Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YJL158C 0.62
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YGL158W 0.61
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YOR212W 0.61
STE4
G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YOL155C 0.61
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YDR517W 0.61
GRH1
Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YJL198W 0.61
PHO90
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YOL012C 0.60
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YDL048C 0.60
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YCR031C 0.60
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YMR212C 0.60
EFR3
Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies and is phosphorylated
YPR080W 0.60
TEF1
Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YNL251C 0.59
NRD1
RNA-binding protein that interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), required for transcription termination and 3' end maturation of nonpolyadenylated RNAs
YIL009C-A 0.59
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YFR031C-A 0.59
RPL2A
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YLR449W 0.59
FPR4
Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YPR063C 0.59 ER-localized protein of unknown function
YBL092W 0.59
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YLR108C 0.58 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YGR121W-A 0.58 Putative protein of unknown function
YER083C 0.58
GET2
Subunit of the GET complex; required for meiotic nuclear division and for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion; may be involved in cell wall function
YOR332W 0.57
VMA4
Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
YHR043C 0.57
DOG2
2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
YGL145W 0.57
TIP20
Peripheral membrane protein required for fusion of COPI vesicles with the ER, prohibits back-fusion of COPII vesicles with the ER, may act as a sensor for vesicles at the ER membrane; interacts with Sec20p
YER146W 0.57
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YNL338W 0.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YOR046C 0.57
DBP5
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination
YJL106W 0.56
IME2
Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YML043C 0.56
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YML088W 0.56
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YOR011W 0.56
AUS1
Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth
YGL080W 0.55
FMP37
Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKR074W 0.55
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YGL034C 0.55 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR087W 0.55
YVC1
Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock
YGR279C 0.55
SCW4
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YOR342C 0.55 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus

Network of associatons between targets according to the STRING database.

First level regulatory network of YML081W

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
1.3 3.8 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.7 6.2 GO:0006814 sodium ion transport(GO:0006814)
0.7 2.0 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.7 2.7 GO:1900436 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.6 2.6 GO:0000752 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.6 4.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.6 2.5 GO:0000296 spermine transport(GO:0000296)
0.5 3.8 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.5 2.4 GO:0006177 GMP biosynthetic process(GO:0006177)
0.4 1.2 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.4 3.6 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.4 2.0 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.4 1.2 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.3 1.0 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.3 1.0 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.3 0.6 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.3 0.6 GO:0006110 regulation of glycolytic process(GO:0006110)
0.3 2.7 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.3 2.1 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.3 0.8 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.3 1.1 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.3 0.8 GO:0015693 magnesium ion transport(GO:0015693)
0.2 0.7 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.2 0.5 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.2 2.4 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.2 1.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.2 1.2 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.2 0.6 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.2 2.3 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 0.8 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.2 0.6 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.2 1.5 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.2 0.9 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.2 0.7 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.2 1.1 GO:0007030 Golgi organization(GO:0007030)
0.2 1.1 GO:0070941 eisosome assembly(GO:0070941)
0.2 0.5 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.2 0.5 GO:0000092 mitotic anaphase B(GO:0000092)
0.2 0.8 GO:0007535 donor selection(GO:0007535)
0.2 1.3 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.2 2.0 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.2 1.3 GO:0006857 oligopeptide transport(GO:0006857)
0.2 0.5 GO:0009847 spore germination(GO:0009847)
0.2 0.3 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.2 0.5 GO:0006567 threonine catabolic process(GO:0006567)
0.2 2.4 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.2 0.2 GO:0032233 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.2 0.5 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.9 GO:0045116 protein neddylation(GO:0045116)
0.1 0.4 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.7 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.3 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
0.1 0.7 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 0.6 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.6 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.3 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.1 0.5 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 0.5 GO:0031057 negative regulation of histone modification(GO:0031057)
0.1 0.5 GO:0018196 peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.5 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.9 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.1 0.3 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.1 0.5 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.1 0.5 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.1 0.5 GO:0015833 peptide transport(GO:0015833)
0.1 1.4 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.1 0.3 GO:0072523 purine-containing compound catabolic process(GO:0072523)
0.1 1.1 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.4 GO:0015680 intracellular copper ion transport(GO:0015680)
0.1 0.7 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.1 1.7 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.3 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.5 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 0.8 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.7 GO:0046677 response to antibiotic(GO:0046677)
0.1 1.2 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 0.4 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 0.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.5 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.1 14.4 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.8 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.1 0.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 0.4 GO:0043097 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.1 1.1 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 1.3 GO:0006415 translational termination(GO:0006415)
0.1 0.7 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 1.3 GO:0046434 organophosphate catabolic process(GO:0046434)
0.1 2.2 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.7 GO:0035376 sterol import(GO:0035376)
0.1 0.3 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.1 0.4 GO:0042435 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.1 1.6 GO:0051452 vacuolar acidification(GO:0007035) pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.1 0.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.1 0.5 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 2.5 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.1 2.7 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.7 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.2 GO:0006026 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.1 0.2 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.1 0.1 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.9 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 0.5 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 1.6 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.2 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.1 0.1 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.1 7.1 GO:0032543 mitochondrial translation(GO:0032543)
0.1 0.1 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 0.1 GO:0090153 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.1 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.1 1.1 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.9 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 0.2 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.1 0.2 GO:0015691 cadmium ion transport(GO:0015691)
0.1 0.1 GO:0032365 intracellular lipid transport(GO:0032365)
0.1 0.2 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.1 0.2 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.2 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 0.2 GO:0010822 positive regulation of mitochondrion organization(GO:0010822)
0.1 0.3 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.3 GO:0006458 'de novo' protein folding(GO:0006458)
0.1 0.5 GO:0015698 inorganic anion transport(GO:0015698)
0.1 0.6 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.1 0.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418) amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.1 1.3 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 0.3 GO:0000011 vacuole inheritance(GO:0000011)
0.0 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.1 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.0 0.2 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.9 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.0 0.0 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.0 0.5 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.0 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.0 0.2 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.0 0.1 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.0 0.6 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.2 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.2 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.0 0.3 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.2 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.0 1.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.7 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.2 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.0 1.0 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.3 GO:0006012 galactose metabolic process(GO:0006012)
0.0 0.2 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.0 0.3 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.3 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 5.5 GO:0006364 rRNA processing(GO:0006364)
0.0 0.1 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.0 0.1 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.0 0.2 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.0 0.1 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.0 0.4 GO:0030011 maintenance of cell polarity(GO:0030011)
0.0 0.1 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.4 GO:0070838 divalent metal ion transport(GO:0070838)
0.0 0.2 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.1 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.2 GO:0001301 progressive alteration of chromatin involved in cell aging(GO:0001301)
0.0 0.1 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.1 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 0.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0006885 regulation of pH(GO:0006885)
0.0 0.2 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.5 GO:0044108 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.0 0.2 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.2 GO:0006038 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.0 0.3 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.3 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.2 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.3 GO:0046785 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.0 0.4 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0006551 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098)
0.0 0.3 GO:0006469 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.0 0.3 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.3 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.0 0.0 GO:0016180 snRNA processing(GO:0016180) snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 0.1 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.1 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.0 0.1 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.0 GO:0072530 cytosine transport(GO:0015856) purine-containing compound transmembrane transport(GO:0072530)
0.0 0.2 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.7 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.0 0.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:2000278 nucleolus organization(GO:0007000) 7-methylguanosine RNA capping(GO:0009452) regulation of telomere maintenance via telomerase(GO:0032210) RNA capping(GO:0036260) regulation of telomere maintenance via telomere lengthening(GO:1904356) regulation of DNA biosynthetic process(GO:2000278)
0.0 1.1 GO:0043623 cellular protein complex assembly(GO:0043623)
0.0 0.0 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.3 GO:0006400 tRNA modification(GO:0006400)
0.0 0.0 GO:0033875 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627) mitochondrial protein processing(GO:0034982)
0.0 0.1 GO:0051666 actin cortical patch localization(GO:0051666)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.5 0.5 GO:0032156 septin ring(GO:0005940) septin cytoskeleton(GO:0032156)
0.3 1.3 GO:0031518 CBF3 complex(GO:0031518)
0.3 1.3 GO:0044697 HICS complex(GO:0044697)
0.3 1.7 GO:0032126 eisosome(GO:0032126)
0.3 0.9 GO:0005845 mRNA cap binding complex(GO:0005845)
0.3 1.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 0.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 3.8 GO:0030118 clathrin coat(GO:0030118)
0.2 1.0 GO:0000938 GARP complex(GO:0000938)
0.2 0.7 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.9 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2 0.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.2 0.7 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.2 0.9 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 1.1 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 1.5 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 0.6 GO:0035649 Nrd1 complex(GO:0035649)
0.2 0.8 GO:0030658 transport vesicle membrane(GO:0030658)
0.2 0.6 GO:0043529 GET complex(GO:0043529)
0.2 0.6 GO:0070939 Dsl1p complex(GO:0070939)
0.2 0.6 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.2 2.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 5.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 0.8 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.2 0.7 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.2 1.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 0.9 GO:0005871 kinesin complex(GO:0005871)
0.1 4.4 GO:0005844 polysome(GO:0005844)
0.1 1.1 GO:0043614 multi-eIF complex(GO:0043614)
0.1 11.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.4 GO:0070209 ASTRA complex(GO:0070209) R2TP complex(GO:0097255)
0.1 0.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.4 GO:0000814 ESCRT II complex(GO:0000814)
0.1 0.1 GO:0030428 cell septum(GO:0030428)
0.1 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.1 0.4 GO:0032160 septin filament array(GO:0032160)
0.1 0.8 GO:0031933 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 0.9 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.1 3.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 3.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 5.3 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 0.3 GO:0031415 NatA complex(GO:0031415)
0.1 15.6 GO:0005933 cellular bud(GO:0005933)
0.1 1.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 0.1 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.6 GO:0005688 U6 snRNP(GO:0005688)
0.1 0.3 GO:0044611 nuclear pore inner ring(GO:0044611)
0.1 1.0 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 0.2 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.3 GO:0034044 exomer complex(GO:0034044)
0.1 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.4 GO:0000346 transcription export complex(GO:0000346)
0.1 0.9 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.1 0.2 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.1 0.2 GO:0032301 MutSalpha complex(GO:0032301)
0.1 0.1 GO:0000133 polarisome(GO:0000133)
0.1 0.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.4 GO:0005791 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.2 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.4 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.2 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.0 0.7 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 4.4 GO:0098852 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.4 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.2 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.9 GO:0044445 cytosolic part(GO:0044445)
0.0 0.3 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.3 GO:0071782 cortical endoplasmic reticulum(GO:0032541) endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.1 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 0.2 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.0 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.0 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.2 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0000930 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.0 0.1 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.0 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 2.2 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.0 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.0 GO:0005794 Golgi apparatus(GO:0005794)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 8.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.0 4.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.8 2.4 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.7 4.3 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.7 2.8 GO:0016841 ammonia-lyase activity(GO:0016841)
0.6 1.9 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.6 2.5 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.5 5.6 GO:0030276 clathrin binding(GO:0030276)
0.5 1.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.5 1.8 GO:1904680 peptide transmembrane transporter activity(GO:1904680)
0.5 0.5 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.5 3.6 GO:0015081 sodium ion transmembrane transporter activity(GO:0015081)
0.4 3.5 GO:0005216 ion channel activity(GO:0005216)
0.4 1.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 1.4 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.3 1.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.3 1.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.3 1.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.3 1.1 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.2 2.2 GO:0010181 FMN binding(GO:0010181)
0.2 0.7 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.2 0.9 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.9 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.2 1.5 GO:0016778 diphosphotransferase activity(GO:0016778)
0.2 0.6 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 0.6 GO:0019003 GDP binding(GO:0019003)
0.2 0.8 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 1.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 1.3 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 0.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 2.4 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 0.7 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 3.8 GO:0019901 protein kinase binding(GO:0019901)
0.2 0.5 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.2 0.2 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.1 0.9 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 2.5 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.4 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.1 0.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 3.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.4 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.4 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.7 GO:0070403 NAD+ binding(GO:0070403)
0.1 0.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 1.1 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 0.5 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.1 0.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.4 GO:0099516 ion antiporter activity(GO:0099516)
0.1 4.0 GO:0008186 RNA-dependent ATPase activity(GO:0008186)
0.1 22.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.5 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.6 GO:0030145 manganese ion binding(GO:0030145)
0.1 0.6 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 1.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.4 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.4 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.1 1.5 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 0.9 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.2 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.4 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.2 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.1 1.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.8 GO:0004497 monooxygenase activity(GO:0004497)
0.1 0.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.1 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.3 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.1 5.1 GO:0003924 GTPase activity(GO:0003924)
0.1 0.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.5 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.3 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.6 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.2 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.3 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.1 0.6 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.4 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.6 GO:0043495 protein anchor(GO:0043495)
0.1 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 0.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.1 0.3 GO:0004312 fatty acid synthase activity(GO:0004312)
0.1 0.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 0.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.1 1.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.7 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.1 0.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.9 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.4 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 1.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.2 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 2.5 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.0 0.2 GO:0070717 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0 0.3 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 1.0 GO:0046873 metal ion transmembrane transporter activity(GO:0046873)
0.0 0.1 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.0 0.2 GO:0019205 nucleobase-containing compound kinase activity(GO:0019205)
0.0 0.2 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.0 0.1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.8 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.4 GO:0050661 NADP binding(GO:0050661)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.3 GO:0019239 deaminase activity(GO:0019239)
0.0 0.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)
0.0 1.1 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.1 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 4.2 GO:0003723 RNA binding(GO:0003723)
0.0 0.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.4 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.0 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.1 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 0.1 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.4 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 0.1 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 0.1 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.1 GO:0005048 signal sequence binding(GO:0005048)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 0.8 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.3 PID FOXO PATHWAY FoxO family signaling
0.1 0.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.3 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.1 0.2 PID SHP2 PATHWAY SHP2 signaling
0.0 0.2 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.1 PID E2F PATHWAY E2F transcription factor network
0.0 0.1 PID ATR PATHWAY ATR signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 0.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 0.9 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.2 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 0.8 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.2 0.5 REACTOME TRIF MEDIATED TLR3 SIGNALING Genes involved in TRIF mediated TLR3 signaling
0.2 1.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 2.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 0.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.1 0.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.6 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 0.1 REACTOME GPCR LIGAND BINDING Genes involved in GPCR ligand binding
0.1 0.5 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 0.4 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.1 0.2 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.1 0.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.0 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.0 0.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME PROTEIN FOLDING Genes involved in Protein folding