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Results for YBR239C

Z-value: 1.31

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Transcription factors associated with YBR239C

Gene Symbol Gene ID Gene Info
ERT1
S000000443 Transcriptional regulator of nonfermentable carbon utilization

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ERT1YBR239C-0.891.9e-09Click!

Activity profile of YBR239C motif

Sorted Z-values of YBR239C motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 13.76
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YGR108W 12.52
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YFR056C 12.00 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YGR052W 9.44
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YER131W 8.33
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YLR154C 8.32
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YLR154W-B 7.16 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR050C 6.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR154W-A 6.74 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YNR001W-A 6.34 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YDL047W 6.24
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YDR033W 5.78
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YOR315W 5.58
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YMR083W 5.57
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YDR345C 5.40
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YOR376W-A 5.38 Putative protein of unknown function; identified by fungal homology and RT-PCR
YGL097W 5.17
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YJR094W-A 5.11
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YNL327W 5.10
EGT2
Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner
YEL040W 5.00
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YGL039W 4.73 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YPL263C 4.73
KEL3
Cytoplasmic protein of unknown function
YKR074W 4.66
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YDR385W 4.57
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YLR167W 4.57
RPS31
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YDL075W 4.49
RPL31A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YGR051C 4.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YFL015C 4.21 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YJR105W 4.18
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YFL015W-A 4.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR375C 3.96
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YGL040C 3.79
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YMR082C 3.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL158C 3.76
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YER177W 3.75
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YLR109W 3.66
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YKL096W-A 3.62
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YIL009W 3.58
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YKL063C 3.49 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YIR021W 3.40
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YLR154W-C 3.24
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YER130C 3.23 Hypothetical protein
YIL009C-A 3.20
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YMR202W 3.19
ERG2
C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YOL136C 3.17
PFK27
6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A
YLR287C-A 3.14
RPS30A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein
YIL015W 3.13
BAR1
Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YDR044W 3.12
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YDL048C 3.11
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YGR106C 3.05
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YMR263W 3.01
SAP30
Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance
YBR106W 3.00
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YGR107W 2.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL014W 2.85 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus
YGL158W 2.84
RCK1
Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations
YPL075W 2.83
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YGL209W 2.72
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YER055C 2.67
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YPR157W 2.66 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YMR303C 2.65
ADH2
Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YHL028W 2.61
WSC4
ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
YKL120W 2.60
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YFR054C 2.59 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR029C 2.58
APL4
Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
YKR038C 2.58
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YNL129W 2.58
NRK1
Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
YOR108W 2.57
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YNL289W 2.56
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YER001W 2.42
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YGR249W 2.41
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YBR182C-A 2.40 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR210W 2.32
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YEL001C 2.31
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YDR384C 2.30
ATO3
Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YGL105W 2.30
ARC1
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YMR320W 2.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR108C 2.27 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YDR279W 2.17
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YGL224C 2.17
SDT1
Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives
YGL179C 2.16
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YDR276C 2.13
PMP3
Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential
YCR004C 2.12
YCP4
Protein of unknown function, has sequence and structural similarity to flavodoxins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL050C 2.12
APA1
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p
YGR040W 2.11
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YOR314W 2.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR022C 2.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YMR319C 2.05
FET4
Low-affinity Fe(II) transporter of the plasma membrane
YOL103W 2.01
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YCR002C 2.00
CDC10
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YBL003C 1.99
HTA2
One of two nearly identical (see also HTA1) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YMR102C 1.99 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YAL038W 1.94
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YIL056W 1.93
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YBR177C 1.88
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YNR075W 1.87
COS10
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YBR158W 1.84
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGR251W 1.84 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YJL008C 1.83
CCT8
Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YBR164C 1.82
ARL1
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YFL016C 1.76
MDJ1
Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones
YBL002W 1.74
HTB2
One of two nearly identical (see HTB1) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YCR003W 1.70
MRPL32
Mitochondrial ribosomal protein of the large subunit
YGL009C 1.68
LEU1
Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
YMR194W 1.68
RPL36A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YLR285W 1.67
NNT1
Putative nicotinamide N-methyltransferase, has a role in rDNA silencing and in lifespan determination
YKL180W 1.67
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YOR342C 1.66 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YLR455W 1.65 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDR344C 1.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR150W 1.64
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YLR002C 1.64
NOC3
Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation
YBR067C 1.64
TIP1
Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YDL007W 1.62
RPT2
One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
YGR017W 1.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YEL053W-A 1.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YPR063C 1.61 ER-localized protein of unknown function
YDR292C 1.61
SRP101
Signal recognition particle (SRP) receptor - alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with SRP102p
YLR432W 1.60
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YNR074C 1.59
AIF1
Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase
YMR299C 1.57
DYN3
Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration
YOR293W 1.57
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YDL132W 1.56
CDC53
Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YGL258W 1.55
VEL1
Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YOR047C 1.55
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YLR257W 1.54 Putative protein of unknown function
YPR119W 1.53
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YAL007C 1.52
ERP2
Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YNL035C 1.52 Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene
YOR313C 1.50
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YOR327C 1.48
SNC2
Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YDR447C 1.47
RPS17B
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YIL051C 1.47
MMF1
Mitochondrial protein involved in maintenance of the mitochondrial genome
YPR170W-B 1.46 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YOR272W 1.46
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YOR039W 1.45
CKB2
Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
YPR010C 1.41
RPA135
RNA polymerase I subunit A135
YNL065W 1.41
AQR1
Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids
YOR050C 1.40 Hypothetical protein
YOR063W 1.40
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YHR092C 1.38
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YMR011W 1.37
HXT2
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YEL027W 1.37
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YOR092W 1.36
ECM3
Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YOR357C 1.35
SNX3
Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
YIL064W 1.34 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family
YFR001W 1.34
LOC1
Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YMR119W 1.33
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YMR024W 1.30
MRPL3
Mitochondrial ribosomal protein of the large subunit
YJL115W 1.29
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YHR141C 1.28
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YKL013C 1.26
ARC19
Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YOR029W 1.26 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGL034C 1.25 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL219W 1.24
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YPL144W 1.23
POC4
Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
YOR247W 1.22
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YPL141C 1.22 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YKL122C 1.22
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YML026C 1.21
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YOL155C 1.20
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YMR003W 1.20
AIM34
Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YDL055C 1.16
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YGR180C 1.14
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YMR290C 1.13
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YKL081W 1.13
TEF4
Translation elongation factor EF-1 gamma
YGL001C 1.12
ERG26
C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis
YOR362C 1.11
PRE10
Alpha 7 subunit of the 20S proteasome
YMR296C 1.10
LCB1
Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YGR034W 1.10
RPL26B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YER109C 1.09
FLO8
Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YOR028C 1.09
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YDR365C 1.09
ESF1
Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels
YDR531W 1.08 Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway leading to coenzyme A1
YMR290W-A 1.08 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YCL018W 1.08
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YHR174W 1.08
ENO2
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YHR043C 1.07
DOG2
2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed
YPL145C 1.06
KES1
Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex
YDL076C 1.06
RXT3
Subunit of the RPD3L complex; involved in histone deacetylation
YHR031C 1.05
RRM3
DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YEL047C 1.04 Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies
YFR025C 1.04
HIS2
Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YEL017W 1.04
GTT3
Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery
YJL167W 1.04
ERG20
Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YPR170W-A 1.03 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YKL218C 1.02
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YOL086C 1.01
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YJL033W 1.00
HCA4
Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis
YDR418W 0.99
RPL12B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins
YOL012C 0.99
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YFL010W-A 0.99
AUA1
Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease
YLR325C 0.99
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YOR271C 0.98
FSF1
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YEL051W 0.97
VMA8
Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
YPL178W 0.96
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YAR002W 0.95
NUP60
Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance
YGL202W 0.95
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YOR312C 0.95
RPL20B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein
YHR045W 0.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YKR041W 0.95 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus

Network of associatons between targets according to the STRING database.

First level regulatory network of YBR239C

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 13.8 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
2.0 14.1 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
1.5 4.6 GO:0045901 positive regulation of translational elongation(GO:0045901)
1.5 10.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.4 4.1 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
1.4 4.1 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.3 4.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.1 20.0 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.1 5.4 GO:0006110 regulation of glycolytic process(GO:0006110)
1.0 6.9 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.0 8.7 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.9 2.6 GO:0008272 sulfate transport(GO:0008272)
0.8 2.4 GO:0044209 AMP salvage(GO:0044209)
0.8 5.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.7 3.0 GO:1900434 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.7 3.5 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.7 4.6 GO:0043171 peptide catabolic process(GO:0043171)
0.6 3.2 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.5 1.6 GO:0060548 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.5 1.6 GO:0042981 regulation of cell death(GO:0010941) regulation of apoptotic process(GO:0042981) regulation of programmed cell death(GO:0043067)
0.5 2.1 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.5 2.1 GO:0000296 spermine transport(GO:0000296)
0.5 2.0 GO:0015680 intracellular copper ion transport(GO:0015680) iron ion transmembrane transport(GO:0034755)
0.5 4.1 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.5 2.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.5 3.5 GO:0043457 regulation of cellular respiration(GO:0043457)
0.5 6.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 6.5 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.5 2.3 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.4 0.9 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
0.4 0.9 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.4 4.2 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.4 3.4 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.4 2.1 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.4 2.4 GO:0006491 N-glycan processing(GO:0006491)
0.4 1.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.4 1.9 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.4 1.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.4 4.1 GO:0006817 phosphate ion transport(GO:0006817)
0.4 1.1 GO:0043902 starch metabolic process(GO:0005982) starch catabolic process(GO:0005983) regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter(GO:0035956) positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0035957) positive regulation of multi-organism process(GO:0043902) regulation of starch catabolic process(GO:2000881) positive regulation of starch catabolic process(GO:2000883) regulation of starch metabolic process(GO:2000904) positive regulation of starch metabolic process(GO:2000906)
0.4 1.1 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.3 1.3 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898) response to ketone(GO:1901654)
0.3 0.9 GO:1902223 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.3 6.8 GO:0006334 nucleosome assembly(GO:0006334)
0.3 6.2 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.3 1.0 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.3 7.3 GO:0097384 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.3 0.8 GO:0035952 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.3 5.7 GO:0006448 regulation of translational elongation(GO:0006448)
0.3 2.8 GO:0030011 maintenance of cell polarity(GO:0030011)
0.3 1.5 GO:0006021 inositol biosynthetic process(GO:0006021)
0.2 1.0 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.2 1.4 GO:0032973 amino acid export(GO:0032973)
0.2 1.8 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.2 0.8 GO:0046417 chorismate biosynthetic process(GO:0009423) chorismate metabolic process(GO:0046417)
0.2 0.4 GO:0072367 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 0.8 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.2 0.2 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.2 1.0 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.2 1.1 GO:0015696 ammonium transport(GO:0015696)
0.2 0.6 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.2 2.8 GO:0007009 plasma membrane organization(GO:0007009)
0.2 1.5 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082)
0.2 4.7 GO:0006885 regulation of pH(GO:0006885)
0.2 0.9 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.2 3.2 GO:0032508 DNA duplex unwinding(GO:0032508)
0.2 0.7 GO:0098742 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.2 2.3 GO:0007120 axial cellular bud site selection(GO:0007120)
0.2 0.5 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.2 0.5 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.2 0.8 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.2 21.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 0.2 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
0.2 1.0 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 0.9 GO:0042823 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 0.3 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.4 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.1 2.2 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.4 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 1.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 4.2 GO:0045047 protein targeting to ER(GO:0045047)
0.1 1.1 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 1.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 2.1 GO:1901136 carbohydrate derivative catabolic process(GO:1901136)
0.1 0.7 GO:0015695 organic cation transport(GO:0015695)
0.1 1.5 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.5 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 1.6 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 0.3 GO:0015691 cadmium ion transport(GO:0015691)
0.1 0.3 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.1 0.3 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 1.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 1.5 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 0.3 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.1 0.6 GO:0007030 Golgi organization(GO:0007030)
0.1 1.7 GO:0010970 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.1 0.3 GO:0042938 dipeptide transport(GO:0042938)
0.1 1.2 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 0.5 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.1 2.3 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 1.7 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.1 0.4 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.1 2.8 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 1.3 GO:0006356 regulation of transcription from RNA polymerase I promoter(GO:0006356)
0.1 1.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.4 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.1 0.3 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.1 0.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 0.2 GO:0009090 homoserine biosynthetic process(GO:0009090)
0.1 1.3 GO:0006414 translational elongation(GO:0006414)
0.1 1.2 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.1 0.4 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 0.2 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216) regulation of DNA-templated transcription, termination(GO:0031554)
0.1 0.4 GO:0051325 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318) interphase(GO:0051325) mitotic interphase(GO:0051329)
0.1 0.2 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 0.2 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.1 0.2 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472)
0.1 0.2 GO:0043471 regulation of carbohydrate catabolic process(GO:0043470) regulation of cellular carbohydrate catabolic process(GO:0043471)
0.1 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.2 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 2.1 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.1 0.1 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.1 0.1 GO:0019357 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.1 0.4 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.2 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.1 1.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.3 GO:0070589 cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.1 0.4 GO:0015677 copper ion import(GO:0015677)
0.1 1.3 GO:0016075 rRNA catabolic process(GO:0016075) ncRNA catabolic process(GO:0034661)
0.1 0.3 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.2 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 0.2 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 0.5 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.5 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 0.4 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.1 0.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.1 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 0.2 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.4 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 1.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 1.4 GO:0006506 GPI anchor biosynthetic process(GO:0006506) glycolipid biosynthetic process(GO:0009247)
0.0 0.4 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.1 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.0 0.2 GO:0035269 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.7 GO:0090329 regulation of DNA-dependent DNA replication(GO:0090329)
0.0 0.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.0 0.4 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.4 GO:0006415 translational termination(GO:0006415)
0.0 4.6 GO:0016072 rRNA metabolic process(GO:0016072)
0.0 0.3 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.0 0.2 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.0 0.9 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 1.5 GO:0008033 tRNA processing(GO:0008033)
0.0 0.2 GO:0015791 polyol transport(GO:0015791)
0.0 0.2 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.2 GO:0006541 glutamine metabolic process(GO:0006541)
0.0 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.3 GO:0006206 pyrimidine nucleobase metabolic process(GO:0006206)
0.0 1.2 GO:0000910 cytokinesis(GO:0000910)
0.0 0.2 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 0.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.2 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0045116 protein neddylation(GO:0045116)
0.0 0.5 GO:0007015 actin filament organization(GO:0007015)
0.0 0.0 GO:0015809 arginine transport(GO:0015809)
0.0 0.2 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.0 0.1 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.6 GO:0007124 pseudohyphal growth(GO:0007124)
0.0 0.4 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.3 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086) cell cycle G2/M phase transition(GO:0044839)
0.0 0.2 GO:0042886 amide transport(GO:0042886)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.0 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0019748 secondary metabolic process(GO:0019748)
0.0 0.1 GO:0016233 telomere capping(GO:0016233)
0.0 0.0 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.0 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.5 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.0 GO:0046219 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.7 5.1 GO:0030428 cell septum(GO:0030428)
0.9 15.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.8 7.6 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.8 2.5 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.8 3.1 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.6 1.7 GO:0070545 PeBoW complex(GO:0070545)
0.5 2.6 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.5 3.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.4 1.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.4 2.6 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.4 5.8 GO:0000786 nucleosome(GO:0000786)
0.4 24.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 2.0 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 1.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 1.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.3 1.7 GO:0030689 Noc complex(GO:0030689)
0.3 1.2 GO:0042597 periplasmic space(GO:0042597)
0.3 0.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 1.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 22.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 0.8 GO:0000417 HIR complex(GO:0000417)
0.3 3.8 GO:0033698 Rpd3L complex(GO:0033698)
0.2 1.4 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.2 2.5 GO:0030867 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.2 3.1 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 1.2 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.2 1.2 GO:0000136 alpha-1,6-mannosyltransferase complex(GO:0000136)
0.2 2.7 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.0 GO:0034518 RNA cap binding complex(GO:0034518)
0.2 0.8 GO:0030286 dynein complex(GO:0030286)
0.2 1.3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 1.2 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 0.8 GO:0034044 exomer complex(GO:0034044)
0.2 1.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 0.6 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.2 1.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 1.6 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.7 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.0 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.4 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.1 1.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 3.0 GO:0005802 trans-Golgi network(GO:0005802)
0.1 0.5 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 0.8 GO:0034455 t-UTP complex(GO:0034455)
0.1 0.9 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 1.8 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 0.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.1 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.1 0.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.2 GO:0031518 CBF3 complex(GO:0031518)
0.1 2.8 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.3 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.1 3.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.2 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 0.4 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.1 2.4 GO:0044445 cytosolic part(GO:0044445)
0.1 0.5 GO:0000145 exocyst(GO:0000145)
0.1 0.2 GO:0030132 clathrin-coated pit(GO:0005905) AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) clathrin coat of coated pit(GO:0030132) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 2.2 GO:0030686 90S preribosome(GO:0030686)
0.1 0.4 GO:0070772 PAS complex(GO:0070772)
0.1 2.2 GO:0005811 lipid particle(GO:0005811)
0.1 0.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.2 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.3 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.3 GO:0000133 polarisome(GO:0000133)
0.1 8.5 GO:0005933 cellular bud(GO:0005933)
0.0 0.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.2 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 0.2 GO:0000817 COMA complex(GO:0000817)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 2.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 5.0 GO:0005730 nucleolus(GO:0005730)
0.0 3.2 GO:0005635 nuclear envelope(GO:0005635)
0.0 0.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 5.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.1 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541) endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 1.4 GO:0005840 ribosome(GO:0005840)
0.0 0.1 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.2 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.3 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.1 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.0 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
2.0 11.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
1.7 6.8 GO:0019206 nucleoside kinase activity(GO:0019206)
1.5 9.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.4 4.1 GO:0051219 phosphoprotein binding(GO:0051219)
1.1 3.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.1 3.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
1.0 4.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.9 2.6 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.8 2.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.8 9.0 GO:0005199 structural constituent of cell wall(GO:0005199)
0.7 17.2 GO:0019901 protein kinase binding(GO:0019901)
0.7 2.7 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.7 2.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.7 2.0 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.6 2.4 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.6 2.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.5 2.2 GO:0008252 nucleotidase activity(GO:0008252)
0.5 2.1 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.5 3.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.5 2.3 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.5 4.6 GO:0031386 protein tag(GO:0031386)
0.4 2.2 GO:0004707 MAP kinase activity(GO:0004707)
0.4 6.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 1.3 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.4 0.8 GO:0008443 phosphofructokinase activity(GO:0008443)
0.4 1.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.4 1.9 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.4 1.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.4 3.0 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.4 1.1 GO:0015248 sterol transporter activity(GO:0015248)
0.3 1.0 GO:0000339 RNA cap binding(GO:0000339)
0.3 2.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.3 2.8 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.3 0.9 GO:0016872 intramolecular lyase activity(GO:0016872)
0.3 1.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 1.1 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 2.8 GO:0030276 clathrin binding(GO:0030276)
0.3 0.8 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.3 1.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.3 2.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 1.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.3 2.6 GO:0031490 chromatin DNA binding(GO:0031490)
0.3 7.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.3 5.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.3 10.0 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 0.5 GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding(GO:0001082)
0.2 0.7 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 2.3 GO:0005516 calmodulin binding(GO:0005516)
0.2 0.7 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)
0.2 1.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.2 43.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 0.8 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.2 1.2 GO:0008312 7S RNA binding(GO:0008312)
0.2 2.7 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 0.9 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.2 5.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 1.1 GO:0016408 C-acyltransferase activity(GO:0016408)
0.2 1.5 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.2 0.7 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 1.8 GO:0010181 FMN binding(GO:0010181)
0.2 0.5 GO:0032451 demethylase activity(GO:0032451)
0.2 2.7 GO:0003774 motor activity(GO:0003774)
0.2 0.5 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.1 1.3 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 1.0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.3 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.5 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.1 5.2 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1 0.3 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 0.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.6 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 1.9 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 5.1 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.1 GO:0019003 GDP binding(GO:0019003)
0.1 0.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 1.2 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 1.1 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 0.6 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.2 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 0.2 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.4 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.1 1.0 GO:0004659 prenyltransferase activity(GO:0004659)
0.1 0.7 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 2.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.0 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.5 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.2 GO:0072341 modified amino acid binding(GO:0072341)
0.1 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.2 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.1 0.2 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1 0.2 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.1 1.1 GO:0030515 snoRNA binding(GO:0030515)
0.1 1.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.4 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.1 0.3 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.5 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315) manganese ion transmembrane transporter activity(GO:0005384)
0.0 0.2 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.2 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 2.1 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.6 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.1 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 1.3 GO:0003779 actin binding(GO:0003779)
0.0 0.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 0.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.3 GO:0005216 ion channel activity(GO:0005216)
0.0 0.1 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 0.6 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.4 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.4 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 0.1 GO:0008242 omega peptidase activity(GO:0008242)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.7 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.3 GO:0000049 tRNA binding(GO:0000049)
0.0 0.3 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.0 0.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.8 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.1 GO:0001167 RNA polymerase I transcription factor activity, sequence-specific DNA binding(GO:0001167) transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.0 0.2 GO:0019904 protein domain specific binding(GO:0019904)
0.0 0.6 GO:0042393 histone binding(GO:0042393)
0.0 0.0 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.2 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.0 0.6 GO:0016791 phosphatase activity(GO:0016791)
0.0 0.1 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.0 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.0 0.4 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 0.5 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.1 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID MYC PATHWAY C-MYC pathway
0.0 0.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 0.5 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.3 2.1 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.3 0.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 1.2 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 5.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.2 0.6 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 0.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 0.5 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.1 0.1 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.5 REACTOME TRANSCRIPTION Genes involved in Transcription