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Results for SWI6

Z-value: 1.61

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Transcription factors associated with SWI6

Gene Symbol Gene ID Gene Info
SWI6
S000004172 Transcription cofactor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SWI6YLR182W0.331.0e-01Click!

Activity profile of SWI6 motif

Sorted Z-values of SWI6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YNL301C 23.67
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YPL256C 20.23
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YDL055C 19.40
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YNL289W 19.06
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YNL300W 18.21 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YER070W 16.28
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YJL158C 15.51
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YGR108W 15.38
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGL179C 14.90
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YKL096W-A 14.69
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YIR021W 13.97
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YKR092C 12.92
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YFR055W 12.59
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YDR509W 11.48 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR508C 11.29
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YPR119W 11.19
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YOR226C 11.09
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YFR056C 10.95 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YKR013W 10.29
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YMR199W 10.11
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YGR148C 9.61
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YDR044W 9.58
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YGL147C 8.60
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YPL163C 8.59
SVS1
Cell wall and vacuolar protein, required for wild-type resistance to vanadate
YCL063W 8.41
VAC17
Protein involved in vacuole inheritance; acts as a vacuole-specific receptor for myosin Myo2p
YFL045C 8.40
SEC53
Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YKR012C 8.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YGL225W 8.15
VRG4
Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YLR183C 8.08
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YEL053W-A 7.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YEL040W 7.80
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YLR185W 7.77
RPL37A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YDL211C 7.73 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YOR342C 7.46 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YMR307W 7.39
GAS1
Beta-1,3-glucanosyltransferase, required for cell wall assembly; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor
YOL101C 7.35
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YOL007C 7.22
CSI2
Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene
YIL069C 7.14
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YER001W 7.08
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YIL118W 6.99
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YNL030W 6.82
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YGL039W 6.71 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YMR049C 6.64
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YLR110C 6.63
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YOL015W 6.50
IRC10
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YGL031C 6.45
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YKL218C 6.44
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YCL064C 6.28
CHA1
Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
YKL122C 6.22
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YEL001C 6.13
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YBR143C 6.09
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YGR152C 6.08
RSR1
GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YHR141C 5.92
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YLL045C 5.74
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YGL030W 5.69
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YOR315W 5.68
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YCR034W 5.66
FEN1
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YBR210W 5.60
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YBR088C 5.50
POL30
Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YDL191W 5.48
RPL35A
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein
YDR309C 5.48
GIC2
Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
YGR187C 5.42
HGH1
Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YDL003W 5.31
MCD1
Essential protein required for sister chromatid cohesion in mitosis and meiosis; subunit of the cohesin complex; expression is cell cycle regulated and peaks in S phase
YDR002W 5.24
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YDR224C 5.24
HTB1
One of two nearly identical (see HTB2) histone H2B subtypes required for chromatin assembly and chromosome function; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation
YJR094W-A 5.15
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YKL165C 5.15
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YLR154C 5.13
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YOL016C 4.91
CMK2
Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YLR339C 4.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0
YCL024W 4.79
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YGL201C 4.78
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YBR162C 4.78
TOS1
Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YLR340W 4.70
RPP0
Conserved ribosomal protein P0 similar to rat P0, human P0, and E. coli L10e; shown to be phosphorylated on serine 302
YKL110C 4.68
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YKR093W 4.67
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YJL115W 4.67
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YHL033C 4.65
RPL8A
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YDR225W 4.60
HTA1
One of two nearly identical (see also HTA2) histone H2A subtypes; core histone required for chromatin assembly and chromosome function; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
YGR214W 4.52
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YPL255W 4.52
BBP1
Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p
YCR065W 4.52
HCM1
Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
YDL219W 4.48
DTD1
D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
YDL192W 4.47
ARF1
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YNL231C 4.44
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YGL040C 4.44
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YOR247W 4.44
SRL1
Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants
YLR137W 4.41 Putative protein of unknown function
YGL097W 4.40
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YPR170W-B 4.39 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YGR090W 4.38
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YGR159C 4.35
NSR1
Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
YJL080C 4.34
SCP160
Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
YLR154W-A 4.32 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B 4.29 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOL039W 4.23
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YDL145C 4.23
COP1
Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
YGR040W 4.23
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YPL263C 4.17
KEL3
Cytoplasmic protein of unknown function
YOL103W 4.17
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YOR222W 4.12
ODC2
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
YFL015W-A 4.10 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR381W 4.07
YRA1
Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YIL133C 4.06
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YCL023C 4.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YIL123W 4.05
SIM1
Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YLR186W 4.04
EMG1
Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers
YOR376W-A 4.03 Putative protein of unknown function; identified by fungal homology and RT-PCR
YFL015C 3.99 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YPR157W 3.99 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR189C 3.98
CRH1
Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YLR372W 3.91
SUR4
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YDL227C 3.90
HO
Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
YLR109W 3.83
AHP1
Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p
YHR181W 3.82
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YKL128C 3.78
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YER156C 3.77 Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YDR399W 3.76
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YOL040C 3.75
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YBL085W 3.72
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YMR131C 3.72
RRB1
Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
YFL037W 3.71
TUB2
Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules
YGR138C 3.64
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YNL031C 3.63
HHT2
One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YOL005C 3.62
RPB11
RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit
YBL092W 3.61
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YPR170W-A 3.61 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YMR305C 3.61
SCW10
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YPL227C 3.58
ALG5
UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum
YDR345C 3.57
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDR033W 3.55
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YDR098C 3.53
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YLR180W 3.49
SAM1
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YHR216W 3.47
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YKL068W-A 3.47 Putative protein of unknown function; identified by homology to Ashbya gossypii
YFL022C 3.45
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YDR037W 3.44
KRS1
Lysyl-tRNA synthetase; also identified as a negative regulator of general control of amino acid biosynthesis
YBL009W 3.43
ALK2
Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins
YDR500C 3.41
RPL37B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein
YCR099C 3.40 Putative protein of unknown function
YIL169C 3.35 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YMR083W 3.35
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YDL136W 3.35
RPL35B
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
YLR406C 3.34
RPL31B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YDR510W 3.32
SMT3
Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics
YER134C 3.32 Putative protein of unknown function; non-essential gene
YMR144W 3.29 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YBR112C 3.28
CYC8
General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters
YLR388W 3.25
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YKL182W 3.22
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YBR244W 3.21
GPX2
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YCR018C 3.19
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YER136W 3.19
GDI1
GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YOL049W 3.18
GSH2
Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
YOR375C 3.18
GDH1
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources
YGL012W 3.16
ERG4
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YDR382W 3.16
RPP2B
Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YJR123W 3.15
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YKL212W 3.14
SAC1
Phosphatidylinositol (PI) phosphatase, involved in hydrolysis of PI 3-phosphate, PI 4-phosphate and PI 3,5-bisphosphate to PI; membrane protein localizes to ER and Golgi; involved in protein trafficking, secretion and inositol metabolism
YDL014W 3.13
NOP1
Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
YGL178W 3.13
MPT5
Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest
YGR106C 3.12
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YHR149C 3.11
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YDR385W 3.06
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YJL167W 3.04
ERG20
Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YPL183C 3.03
RTT10
Cytoplasmic protein with a role in regulation of Ty1 transposition
YFR031C-A 3.01
RPL2A
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YNL016W 3.01
PUB1
Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YMR215W 3.00
GAS3
Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall
YGR251W 2.99 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YBL077W 2.99 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C
YMR108W 2.98
ILV2
Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control
YLR355C 2.98
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YCL058C 2.93
FYV5
Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis
YLR042C 2.92 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YIL056W 2.91
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YNL066W 2.88
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YHR007C 2.86
ERG11
Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family
YBR106W 2.85
PHO88
Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YLR084C 2.84
RAX2
N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p
YAL033W 2.84
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YJR043C 2.83
POL32
Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p
YGR140W 2.80
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YGR229C 2.79
SMI1
Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity
YMR303C 2.78
ADH2
Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1
YOR361C 2.77
PRT1
Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes
YPL267W 2.77
ACM1
Cell cycle regulated protein of unknown function; associated with Cdh1p and may supress the APC/C[Cdh1]-mediated proteolysis of mitotic cyclins
YLR150W 2.76
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YBL031W 2.76
SHE1
Cytoskeletal protein of unknown function; overexpression causes growth arrest
YLR108C 2.75 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene
YIR013C 2.72
GAT4
Protein containing GATA family zinc finger motifs
YNL111C 2.71
CYB5
Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
YDR450W 2.70
RPS18A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YGL123C-A 2.69 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGL123W 2.68
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YCR006C 2.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR013C 2.66
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YER073W 2.59
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YJL035C 2.59
TAD2
Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs
YJR143C 2.57
PMT4
Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals

Network of associatons between targets according to the STRING database.

First level regulatory network of SWI6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.8 29.5 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
4.2 12.6 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
3.9 27.0 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
3.2 15.9 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
2.9 8.7 GO:0006567 threonine catabolic process(GO:0006567)
2.5 10.0 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
2.5 17.2 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
2.4 9.6 GO:0030497 fatty acid elongation(GO:0030497)
2.4 18.9 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
2.2 4.5 GO:0006572 tyrosine catabolic process(GO:0006572)
2.1 10.5 GO:0015780 nucleotide-sugar transport(GO:0015780)
2.1 8.2 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
2.0 2.0 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.8 9.2 GO:0006177 GMP biosynthetic process(GO:0006177)
1.8 7.3 GO:0017157 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
1.8 1.8 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
1.7 5.2 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
1.7 6.6 GO:0000752 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
1.6 4.8 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
1.6 3.1 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
1.5 12.0 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.4 10.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.4 25.4 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
1.4 5.6 GO:2000531 regulation of fatty acid biosynthetic process by transcription from RNA polymerase II promoter(GO:0100070) regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter(GO:2000531)
1.4 2.8 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
1.4 6.9 GO:2000758 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
1.4 2.7 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
1.3 2.7 GO:0009409 response to cold(GO:0009409) cellular response to cold(GO:0070417)
1.3 4.0 GO:0070475 rRNA base methylation(GO:0070475)
1.3 5.3 GO:0015867 ATP transport(GO:0015867)
1.3 3.9 GO:0046677 response to antibiotic(GO:0046677)
1.3 7.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
1.3 2.5 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
1.3 7.6 GO:0006491 N-glycan processing(GO:0006491)
1.2 14.9 GO:0007120 axial cellular bud site selection(GO:0007120)
1.2 3.7 GO:1904667 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.2 15.9 GO:0006037 cell wall chitin metabolic process(GO:0006037)
1.2 27.8 GO:0006334 nucleosome assembly(GO:0006334)
1.2 12.0 GO:0006272 leading strand elongation(GO:0006272)
1.2 4.8 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
1.2 3.5 GO:0045901 positive regulation of translational elongation(GO:0045901)
1.2 5.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.2 3.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.1 153.2 GO:0002181 cytoplasmic translation(GO:0002181)
1.1 4.4 GO:0000296 spermine transport(GO:0000296)
1.1 3.3 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
1.1 4.3 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
1.0 3.1 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
1.0 3.0 GO:0070868 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
1.0 3.9 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.9 2.8 GO:0060548 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.9 8.2 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.9 3.5 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.9 10.6 GO:0006415 translational termination(GO:0006415)
0.9 4.4 GO:0009098 leucine biosynthetic process(GO:0009098)
0.8 8.4 GO:0009262 deoxyribonucleotide metabolic process(GO:0009262) deoxyribonucleotide biosynthetic process(GO:0009263)
0.8 2.5 GO:2000002 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002)
0.8 7.4 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.8 1.6 GO:1901352 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.8 7.0 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.8 1.6 GO:0030541 plasmid partitioning(GO:0030541)
0.8 3.9 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.8 3.1 GO:0006750 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.7 1.5 GO:0032006 regulation of TOR signaling(GO:0032006)
0.7 4.4 GO:0009099 valine biosynthetic process(GO:0009099)
0.7 3.6 GO:0042938 dipeptide transport(GO:0042938)
0.7 2.2 GO:0019413 acetate biosynthetic process(GO:0019413)
0.7 7.9 GO:0006817 phosphate ion transport(GO:0006817)
0.7 3.5 GO:0045338 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.7 4.2 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.7 1.4 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.7 10.9 GO:0000011 vacuole inheritance(GO:0000011)
0.7 2.0 GO:1902223 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.7 2.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.7 1.3 GO:0045128 negative regulation of reciprocal meiotic recombination(GO:0045128)
0.7 0.7 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.6 15.1 GO:0006885 regulation of pH(GO:0006885)
0.6 4.3 GO:0034063 stress granule assembly(GO:0034063)
0.6 17.7 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.6 1.2 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.6 2.3 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.6 8.6 GO:0030474 spindle pole body duplication(GO:0030474)
0.6 11.8 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.6 16.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.6 11.2 GO:0015918 sterol transport(GO:0015918)
0.6 1.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.6 2.8 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.6 1.1 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.6 2.2 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.5 13.7 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.5 2.1 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
0.5 12.6 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.5 3.1 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.5 5.2 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.5 5.2 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.5 5.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.5 3.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.5 2.0 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.5 0.5 GO:0071478 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.5 1.5 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.5 1.4 GO:0046838 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.5 1.9 GO:0051693 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.5 1.4 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.5 1.4 GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448)
0.5 6.4 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.4 1.3 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.4 2.6 GO:0035437 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.4 0.4 GO:0032365 intracellular lipid transport(GO:0032365)
0.4 5.5 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.4 3.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.4 0.8 GO:0000916 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.4 1.2 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.4 3.7 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.4 2.5 GO:0030011 maintenance of cell polarity(GO:0030011)
0.4 1.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.4 4.7 GO:0006284 base-excision repair(GO:0006284)
0.4 2.7 GO:0015791 polyol transport(GO:0015791)
0.4 0.8 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.4 4.7 GO:0070507 regulation of microtubule-based process(GO:0032886) regulation of microtubule cytoskeleton organization(GO:0070507)
0.4 0.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.4 1.8 GO:0006110 regulation of glycolytic process(GO:0006110)
0.3 1.4 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.3 1.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 1.3 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.3 3.6 GO:0010970 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.3 0.6 GO:0007000 nucleolus organization(GO:0007000)
0.3 2.5 GO:0015677 copper ion import(GO:0015677)
0.3 0.9 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.3 0.9 GO:0007050 cell cycle arrest(GO:0007050)
0.3 8.6 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.3 0.3 GO:0000092 mitotic anaphase B(GO:0000092)
0.3 0.3 GO:0032447 protein urmylation(GO:0032447)
0.3 2.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.3 0.6 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.3 0.9 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.3 4.3 GO:0030488 tRNA methylation(GO:0030488)
0.3 1.2 GO:0019346 transsulfuration(GO:0019346) homocysteine metabolic process(GO:0050667)
0.3 2.8 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.3 0.8 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.3 3.3 GO:0032005 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)
0.3 3.2 GO:0034963 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.3 0.8 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.3 0.8 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
0.3 2.6 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.3 4.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.3 6.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.3 0.8 GO:0048313 Golgi inheritance(GO:0048313)
0.3 1.0 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.3 1.5 GO:0032973 amino acid export(GO:0032973)
0.3 1.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.2 8.7 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.2 1.2 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.2 0.5 GO:0048194 Golgi vesicle budding(GO:0048194)
0.2 11.1 GO:0008033 tRNA processing(GO:0008033)
0.2 1.0 GO:0007535 donor selection(GO:0007535)
0.2 1.9 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.2 1.9 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 1.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 0.2 GO:0036228 protein targeting to nuclear inner membrane(GO:0036228)
0.2 0.5 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.2 2.9 GO:0046856 phospholipid dephosphorylation(GO:0046839) phosphatidylinositol dephosphorylation(GO:0046856)
0.2 3.8 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 2.2 GO:0000955 amino acid catabolic process via Ehrlich pathway(GO:0000955)
0.2 2.4 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.2 3.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.2 0.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.2 1.5 GO:0009306 protein secretion(GO:0009306)
0.2 0.8 GO:0043007 maintenance of rDNA(GO:0043007)
0.2 13.3 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.2 0.6 GO:0015693 magnesium ion transport(GO:0015693)
0.2 0.4 GO:0042256 mature ribosome assembly(GO:0042256)
0.2 1.0 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.2 0.7 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.2 0.6 GO:0034389 lipid particle organization(GO:0034389)
0.2 6.6 GO:0006413 translational initiation(GO:0006413)
0.2 1.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 1.4 GO:1902299 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.2 0.5 GO:0006517 protein deglycosylation(GO:0006517)
0.2 0.7 GO:0015883 FAD transport(GO:0015883)
0.2 0.5 GO:0030261 chromosome condensation(GO:0030261)
0.2 1.2 GO:0016559 peroxisome fission(GO:0016559)
0.2 0.5 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.2 2.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.2 1.4 GO:0009636 response to toxic substance(GO:0009636)
0.2 3.4 GO:0009303 rRNA transcription(GO:0009303)
0.2 13.7 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.2 1.0 GO:0071028 nuclear mRNA surveillance(GO:0071028)
0.2 0.5 GO:0046348 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.2 0.3 GO:0071454 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.2 0.8 GO:0036297 interstrand cross-link repair(GO:0036297)
0.2 10.9 GO:0006364 rRNA processing(GO:0006364)
0.1 0.7 GO:0015833 peptide transport(GO:0015833)
0.1 0.3 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.1 0.9 GO:1901658 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.4 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.1 1.0 GO:0006563 L-serine metabolic process(GO:0006563)
0.1 1.1 GO:0042255 ribosome assembly(GO:0042255)
0.1 0.3 GO:0043068 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.1 0.5 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.8 GO:0051028 mRNA transport(GO:0051028)
0.1 0.4 GO:0070589 cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.1 1.0 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.8 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.1 0.2 GO:0006998 nuclear envelope organization(GO:0006998)
0.1 0.1 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.1 0.5 GO:0006448 regulation of translational elongation(GO:0006448)
0.1 0.4 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 1.2 GO:1901663 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.4 GO:0071267 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.1 0.2 GO:0065005 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.8 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 0.4 GO:0006549 isoleucine metabolic process(GO:0006549)
0.1 0.7 GO:0007323 peptide pheromone maturation(GO:0007323)
0.1 0.7 GO:0007009 plasma membrane organization(GO:0007009)
0.1 0.2 GO:0090338 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.1 0.8 GO:0015940 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.1 0.4 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.1 1.1 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.1 0.3 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.1 0.3 GO:0035493 regulation of vesicle fusion(GO:0031338) SNARE complex assembly(GO:0035493) regulation of SNARE complex assembly(GO:0035542)
0.1 0.4 GO:0006613 cotranslational protein targeting to membrane(GO:0006613) SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 3.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.8 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.7 GO:0006012 galactose metabolic process(GO:0006012)
0.1 0.3 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.1 0.2 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.9 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.1 0.4 GO:0006734 NADH metabolic process(GO:0006734)
0.1 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.8 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 3.0 GO:0000747 conjugation with cellular fusion(GO:0000747)
0.1 0.7 GO:0009435 NAD biosynthetic process(GO:0009435)
0.1 1.8 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.1 0.1 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.7 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.3 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1 1.0 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 1.4 GO:0070085 glycosylation(GO:0070085)
0.1 0.1 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.1 0.2 GO:0000076 DNA replication checkpoint(GO:0000076)
0.1 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 0.4 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.1 GO:0010672 regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010672) negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.1 0.1 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.1 0.4 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.1 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.1 0.2 GO:0000735 removal of nonhomologous ends(GO:0000735)
0.1 0.7 GO:0006541 glutamine metabolic process(GO:0006541)
0.1 0.2 GO:0046890 regulation of lipid biosynthetic process(GO:0046890) regulation of phospholipid biosynthetic process(GO:0071071)
0.0 0.4 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.0 0.2 GO:0006862 nucleotide transport(GO:0006862)
0.0 0.0 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.3 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.0 0.5 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.4 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.0 0.1 GO:1902807 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.1 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.6 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.0 3.5 GO:0006468 protein phosphorylation(GO:0006468)
0.0 0.1 GO:2000221 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.0 0.4 GO:0006414 translational elongation(GO:0006414)
0.0 0.1 GO:0006083 acetate metabolic process(GO:0006083)
0.0 0.3 GO:0006760 folic acid-containing compound metabolic process(GO:0006760) pteridine-containing compound metabolic process(GO:0042558)
0.0 0.2 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.0 0.1 GO:0007052 spindle organization(GO:0007051) mitotic spindle organization(GO:0007052)
0.0 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0045744 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032) negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.1 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.0 0.1 GO:0001111 promoter clearance during DNA-templated transcription(GO:0001109) promoter clearance from RNA polymerase II promoter(GO:0001111)
0.0 0.1 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.0 GO:0006399 tRNA metabolic process(GO:0006399)
0.0 0.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.0 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0 0.0 GO:0001304 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 51.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.9 8.7 GO:0030428 cell septum(GO:0030428)
2.4 7.3 GO:0070545 PeBoW complex(GO:0070545)
1.9 5.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.8 21.8 GO:0000788 nuclear nucleosome(GO:0000788)
1.8 12.6 GO:0005880 nuclear microtubule(GO:0005880)
1.7 7.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.7 144.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.7 1.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
1.6 6.5 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
1.3 5.2 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
1.3 5.1 GO:0017053 transcriptional repressor complex(GO:0017053)
1.3 7.6 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
1.2 3.7 GO:0031415 NatA complex(GO:0031415)
1.2 18.6 GO:0005940 septin ring(GO:0005940)
1.2 5.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.2 7.4 GO:0042555 MCM complex(GO:0042555)
1.1 6.7 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
1.1 5.4 GO:0032545 CURI complex(GO:0032545)
1.0 3.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.8 5.9 GO:0000346 transcription export complex(GO:0000346)
0.8 4.2 GO:0005663 DNA replication factor C complex(GO:0005663)
0.8 2.5 GO:0032301 MutSalpha complex(GO:0032301)
0.8 3.2 GO:0000811 GINS complex(GO:0000811)
0.8 5.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.8 4.0 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.8 3.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.8 4.6 GO:0042597 periplasmic space(GO:0042597)
0.8 1.5 GO:0000786 nucleosome(GO:0000786)
0.7 4.3 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.7 51.3 GO:0005576 extracellular region(GO:0005576)
0.7 2.1 GO:0033186 CAF-1 complex(GO:0033186)
0.7 1.4 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.7 42.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.7 3.3 GO:0005871 kinesin complex(GO:0005871)
0.7 2.0 GO:0000930 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.6 3.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.6 6.7 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.6 3.0 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.6 12.8 GO:0009277 fungal-type cell wall(GO:0009277)
0.6 1.7 GO:0030869 RENT complex(GO:0030869)
0.5 3.8 GO:0051233 spindle midzone(GO:0051233)
0.5 16.0 GO:0005844 polysome(GO:0005844)
0.5 4.8 GO:0033553 rDNA heterochromatin(GO:0033553)
0.5 17.9 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.5 4.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.5 1.6 GO:0044697 HICS complex(GO:0044697)
0.5 2.6 GO:0030684 preribosome(GO:0030684)
0.5 2.0 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.4 1.8 GO:0034518 RNA cap binding complex(GO:0034518)
0.4 1.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.4 1.7 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.4 1.7 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.4 2.1 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 2.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.4 4.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.4 3.2 GO:0005688 U6 snRNP(GO:0005688)
0.4 3.5 GO:0042729 DASH complex(GO:0042729)
0.4 3.4 GO:0000137 Golgi cis cisterna(GO:0000137)
0.4 1.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.4 2.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.4 1.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 1.4 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.3 1.4 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.3 1.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 1.3 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.3 1.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.3 1.0 GO:0005796 Golgi lumen(GO:0005796)
0.3 1.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.3 5.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 1.9 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.3 0.9 GO:0030874 nucleolar chromatin(GO:0030874)
0.3 1.5 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.3 1.2 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.3 1.8 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.3 0.9 GO:0000417 HIR complex(GO:0000417)
0.3 2.0 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.3 0.6 GO:0035649 Nrd1 complex(GO:0035649)
0.3 1.2 GO:0044611 nuclear pore inner ring(GO:0044611)
0.3 2.7 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.3 1.1 GO:0030907 MBF transcription complex(GO:0030907)
0.3 3.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.3 0.8 GO:0000229 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
0.3 5.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 1.0 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.2 1.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 1.7 GO:0000792 heterochromatin(GO:0000792)
0.2 27.8 GO:0005935 cellular bud neck(GO:0005935)
0.2 1.0 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 1.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.2 0.5 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.2 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008) post-mRNA release spliceosomal complex(GO:0071014)
0.2 0.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.2 0.2 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.2 3.9 GO:0005657 replication fork(GO:0005657)
0.2 0.9 GO:0097196 Shu complex(GO:0097196)
0.2 2.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 3.8 GO:0016586 RSC complex(GO:0016586)
0.2 1.9 GO:0000243 commitment complex(GO:0000243)
0.2 0.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.2 2.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.2 1.4 GO:0005876 spindle microtubule(GO:0005876)
0.2 0.5 GO:0005787 signal peptidase complex(GO:0005787)
0.2 7.3 GO:0030686 90S preribosome(GO:0030686)
0.2 1.4 GO:0030008 TRAPP complex(GO:0030008)
0.2 0.7 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.2 7.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 0.3 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.2 1.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 5.3 GO:0005811 lipid particle(GO:0005811)
0.2 0.2 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.2 2.9 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.2 0.6 GO:0000938 GARP complex(GO:0000938)
0.2 20.2 GO:0005730 nucleolus(GO:0005730)
0.2 0.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 40.9 GO:0005783 endoplasmic reticulum(GO:0005783)
0.2 0.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.9 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 1.0 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.4 GO:0005884 actin filament(GO:0005884)
0.1 3.1 GO:0005840 ribosome(GO:0005840)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 1.0 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.3 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 6.4 GO:0000139 Golgi membrane(GO:0000139)
0.1 3.5 GO:0005643 nuclear pore(GO:0005643)
0.1 0.3 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.8 GO:0071012 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.1 0.2 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.3 GO:0030897 HOPS complex(GO:0030897)
0.0 0.5 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.0 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.1 GO:0071819 DUBm complex(GO:0071819)
0.0 0.4 GO:0036452 ESCRT complex(GO:0036452)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.2 GO:0034044 exomer complex(GO:0034044)
0.0 6.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 5.5 GO:0005829 cytosol(GO:0005829)
0.0 0.1 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.5 GO:0070847 core mediator complex(GO:0070847)
0.0 0.0 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.3 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.5 19.5 GO:0070568 guanylyltransferase activity(GO:0070568)
3.8 15.1 GO:0016841 ammonia-lyase activity(GO:0016841)
3.2 9.6 GO:0009922 fatty acid elongase activity(GO:0009922)
2.8 73.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
2.6 30.6 GO:0005199 structural constituent of cell wall(GO:0005199)
2.1 12.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
2.1 10.5 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
1.9 7.7 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.8 5.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
1.8 10.6 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
1.7 5.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.7 7.0 GO:0016725 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.7 6.8 GO:0009378 four-way junction helicase activity(GO:0009378)
1.7 6.7 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.6 4.9 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.6 4.8 GO:0072341 modified amino acid binding(GO:0072341)
1.5 6.1 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
1.4 5.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.4 7.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.4 5.6 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
1.3 5.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
1.2 6.2 GO:0008312 7S RNA binding(GO:0008312)
1.2 6.1 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
1.2 11.7 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
1.2 3.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.1 5.7 GO:0036002 pre-mRNA binding(GO:0036002)
1.1 3.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
1.1 47.2 GO:0019843 rRNA binding(GO:0019843)
1.1 4.4 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.1 4.4 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
1.1 1.1 GO:0015248 sterol transporter activity(GO:0015248)
1.0 5.2 GO:0008536 Ran GTPase binding(GO:0008536)
1.0 2.1 GO:0019104 DNA N-glycosylase activity(GO:0019104)
1.0 5.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.9 7.5 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.9 2.8 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.9 2.6 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.9 2.6 GO:0004100 chitin synthase activity(GO:0004100)
0.8 2.5 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.8 5.0 GO:0016408 C-acyltransferase activity(GO:0016408)
0.8 10.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.8 1.6 GO:0000403 Y-form DNA binding(GO:0000403)
0.8 2.4 GO:0019003 GDP binding(GO:0019003)
0.8 4.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.8 3.1 GO:0008310 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.8 23.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.8 2.3 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.7 133.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 3.0 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.7 1.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.7 2.2 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.7 2.9 GO:0005034 osmosensor activity(GO:0005034)
0.7 3.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.7 2.1 GO:1990939 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.7 4.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.7 4.2 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.7 2.1 GO:0043812 phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.7 3.5 GO:0004707 MAP kinase activity(GO:0004707)
0.7 2.0 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.7 5.4 GO:0019842 vitamin binding(GO:0019842)
0.7 16.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.7 5.9 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.6 3.9 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.6 3.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.6 1.7 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.6 0.6 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.6 2.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.5 2.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.5 0.5 GO:0015440 peptide-transporting ATPase activity(GO:0015440) peptide transmembrane transporter activity(GO:1904680)
0.5 4.1 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.5 3.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.5 2.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.5 1.5 GO:0000339 RNA cap binding(GO:0000339)
0.5 4.4 GO:0001055 RNA polymerase II activity(GO:0001055)
0.5 1.5 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.5 1.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.5 1.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.5 3.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.5 29.7 GO:0003924 GTPase activity(GO:0003924)
0.5 5.4 GO:0005516 calmodulin binding(GO:0005516)
0.4 1.3 GO:0001187 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
0.4 6.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.4 4.8 GO:0043495 protein anchor(GO:0043495)
0.4 1.3 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.4 3.4 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.4 1.7 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.4 3.7 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.4 1.2 GO:0003680 AT DNA binding(GO:0003680)
0.4 1.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.4 2.0 GO:0003777 microtubule motor activity(GO:0003777)
0.4 6.3 GO:0030515 snoRNA binding(GO:0030515)
0.4 1.2 GO:0070569 uridylyltransferase activity(GO:0070569)
0.4 1.9 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.4 3.8 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.4 1.1 GO:0070300 phosphatidic acid binding(GO:0070300)
0.4 1.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 1.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.4 12.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.4 3.2 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.3 1.4 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.3 1.7 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 1.3 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.3 1.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.3 1.0 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.3 0.6 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.3 2.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.3 1.5 GO:0034318 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.3 1.2 GO:0008242 omega peptidase activity(GO:0008242)
0.3 7.5 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.3 11.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.3 0.9 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.3 0.3 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.3 0.6 GO:0015645 long-chain fatty acid-CoA ligase activity(GO:0004467) fatty acid ligase activity(GO:0015645)
0.3 8.5 GO:0008135 translation initiation factor activity(GO:0003743) translation factor activity, RNA binding(GO:0008135)
0.3 0.6 GO:0043178 alcohol binding(GO:0043178)
0.3 1.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.3 1.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3 3.6 GO:0003727 single-stranded RNA binding(GO:0003727)
0.3 5.8 GO:0016836 hydro-lyase activity(GO:0016836)
0.3 1.1 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.3 1.4 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.3 0.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.3 1.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 0.7 GO:0005262 calcium channel activity(GO:0005262)
0.2 1.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 1.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.2 1.2 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 0.7 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.2 1.6 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.2 1.6 GO:0051920 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.2 1.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.2 1.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.2 1.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 1.1 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.2 1.0 GO:0008443 phosphofructokinase activity(GO:0008443)
0.2 1.2 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 2.0 GO:0019904 protein domain specific binding(GO:0019904)
0.2 0.8 GO:0004771 sterol esterase activity(GO:0004771)
0.2 0.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 1.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.2 1.5 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.2 1.9 GO:0051015 actin filament binding(GO:0051015)
0.2 2.2 GO:0000182 rDNA binding(GO:0000182)
0.2 1.8 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.2 0.7 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.2 1.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 2.3 GO:0016866 intramolecular transferase activity(GO:0016866)
0.2 0.5 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.2 0.7 GO:0001167 RNA polymerase I transcription factor activity, sequence-specific DNA binding(GO:0001167)
0.2 2.4 GO:0001671 ATPase activator activity(GO:0001671)
0.2 2.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 1.0 GO:0000149 SNARE binding(GO:0000149)
0.2 2.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 0.5 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 3.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.9 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 5.4 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.4 GO:0019202 amino acid kinase activity(GO:0019202)
0.1 0.4 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.5 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 3.9 GO:0003724 RNA helicase activity(GO:0003724)
0.1 0.9 GO:0019211 phosphatase activator activity(GO:0019211)
0.1 0.9 GO:0031386 protein tag(GO:0031386)
0.1 0.9 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 2.2 GO:0008017 microtubule binding(GO:0008017)
0.1 0.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 3.9 GO:0042393 histone binding(GO:0042393)
0.1 1.3 GO:0031491 nucleosome binding(GO:0031491)
0.1 0.3 GO:0000146 microfilament motor activity(GO:0000146)
0.1 0.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.2 GO:0001047 core promoter sequence-specific DNA binding(GO:0001046) core promoter binding(GO:0001047)
0.1 0.9 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.1 0.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 2.9 GO:0030674 protein binding, bridging(GO:0030674)
0.1 1.9 GO:0004519 endonuclease activity(GO:0004519)
0.1 0.4 GO:0003774 motor activity(GO:0003774)
0.1 0.6 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 1.3 GO:0032561 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.6 GO:0033218 amide binding(GO:0033218) peptide binding(GO:0042277)
0.1 6.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.8 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.5 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.1 0.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 1.3 GO:0003779 actin binding(GO:0003779)
0.1 0.4 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 3.0 GO:0003682 chromatin binding(GO:0003682)
0.1 0.3 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.1 0.2 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.1 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.1 0.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.5 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.3 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0030276 clathrin binding(GO:0030276)
0.0 0.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 0.1 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.5 GO:0016853 isomerase activity(GO:0016853)
0.0 0.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.9 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.3 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.1 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.1 GO:0032947 protein complex scaffold(GO:0032947)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 3.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.9 5.8 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.5 4.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
1.0 3.1 PID SHP2 PATHWAY SHP2 signaling
0.8 2.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.7 2.0 PID E2F PATHWAY E2F transcription factor network
0.6 0.6 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.5 5.4 PID ATR PATHWAY ATR signaling pathway
0.5 1.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.4 1.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.4 1.6 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.2 1.2 PID PLK1 PATHWAY PLK1 signaling events
0.2 0.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 0.4 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.2 0.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 0.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 41.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
1.5 4.5 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
1.3 8.0 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
1.3 3.9 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
1.2 3.6 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
1.2 3.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
1.1 4.2 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
1.1 7.4 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
1.0 1.9 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.8 2.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.8 3.3 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.8 1.6 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.5 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 1.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.3 0.6 REACTOME CELL CYCLE MITOTIC Genes involved in Cell Cycle, Mitotic
0.3 1.6 REACTOME TRANSLATION Genes involved in Translation
0.1 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.1 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway