Results for SWI6
Z-value: 1.61
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Transcription factors associated with SWI6
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SWI6
|
S000004172 | Transcription cofactor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YNL301C Show fit | 23.67 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein |
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| YPL256C Show fit | 20.23 |
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) |
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| YDL055C Show fit | 19.40 |
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure |
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| YNL289W Show fit | 19.06 |
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth |
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| YNL300W Show fit | 18.21 |
Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid |
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| YER070W Show fit | 16.28 |
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits |
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| YJL158C Show fit | 15.51 |
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family |
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| YGR108W Show fit | 15.38 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YGL179C Show fit | 14.90 |
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome |
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| YKL096W-A Show fit | 14.69 |
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored |
Network of associatons between targets according to the STRING database.
First level regulatory network of SWI6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 153.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 9.8 | 29.5 | GO:0019673 | GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673) |
| 1.2 | 27.8 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 3.9 | 27.0 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 1.4 | 25.4 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 2.4 | 18.9 | GO:0000321 | re-entry into mitotic cell cycle after pheromone arrest(GO:0000321) |
| 0.6 | 17.7 | GO:0006694 | steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126) |
| 2.5 | 17.2 | GO:0046501 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.6 | 16.9 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 3.2 | 15.9 | GO:0032878 | regulation of establishment or maintenance of cell polarity(GO:0032878) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 144.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.0 | 51.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.7 | 51.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.7 | 42.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 40.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 27.8 | GO:0005935 | cellular bud neck(GO:0005935) |
| 1.8 | 21.8 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.2 | 20.2 | GO:0005730 | nucleolus(GO:0005730) |
| 1.2 | 18.6 | GO:0005940 | septin ring(GO:0005940) |
| 0.5 | 17.9 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 133.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.8 | 73.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 1.1 | 47.2 | GO:0019843 | rRNA binding(GO:0019843) |
| 2.6 | 30.6 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 0.5 | 29.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.8 | 23.9 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 6.5 | 19.5 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.7 | 16.1 | GO:0004520 | endodeoxyribonuclease activity(GO:0004520) |
| 3.8 | 15.1 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.4 | 12.7 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 5.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.5 | 5.4 | PID ATR PATHWAY | ATR signaling pathway |
| 1.5 | 4.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 3.2 | 3.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.0 | 3.1 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.8 | 2.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.7 | 2.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 1.6 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.4 | 1.2 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.2 | 1.2 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 41.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.3 | 8.0 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 1.1 | 7.4 | REACTOME DNA STRAND ELONGATION | Genes involved in DNA strand elongation |
| 1.5 | 4.5 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 1.1 | 4.2 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 1.3 | 3.9 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 1.2 | 3.6 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 1.2 | 3.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.8 | 3.3 | REACTOME CIRCADIAN CLOCK | Genes involved in Circadian Clock |
| 0.8 | 2.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |