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Results for SUM1

Z-value: 4.01

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Transcription factors associated with SUM1

Gene Symbol Gene ID Gene Info
SUM1
S000002718 Transcriptional repressor that regulates middle-sporulation genes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SUM1YDR310C0.442.3e-02Click!

Activity profile of SUM1 motif

Sorted Z-values of SUM1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YLR307C-A 62.68 Putative protein of unknown function
YAL062W 46.80
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YCR005C 43.23
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YDL210W 26.24
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YJL037W 24.34
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YJL133C-A 23.82 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR256W 23.02
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YPL240C 22.50
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YKL177W 20.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YAR035W 20.01
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YAR053W 19.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR087C 19.06
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YOR072W 18.81 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive
YBR117C 18.43
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YLR327C 17.79
TMA10
Protein of unknown function that associates with ribosomes
YAL067C 17.22
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YJR078W 16.85
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YDL223C 16.65
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YNL318C 16.18
HXT14
Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YCL048W 16.01
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YKL178C 15.80
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YHR212C 15.70 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR071C 15.64
NRT1
High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity
YHR126C 15.56 Putative protein of unknown function; transcription dependent upon Azf1p
YMR256C 15.55
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YKR102W 15.49
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YER065C 15.49
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YFR023W 15.18
PES4
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YFL011W 15.03
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YHR053C 15.03
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YJL038C 14.91
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YBR296C 14.68
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YIL160C 14.61
POT1
3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
YOR072W-A 14.12 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR
YER024W 14.05
YAT2
Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane
YAL063C 13.89
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YAR060C 13.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER150W 13.63
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YHR212W-A 13.58 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR076W 13.55
ECM8
Non-essential protein of unknown function
YCL054W 13.28
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YLR004C 13.15
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YPR078C 13.06 Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
YDR218C 13.03
SPR28
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation
YGR258C 12.96
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YGL187C 12.89
COX4
Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YGR059W 12.86
SPR3
Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI
YDR536W 12.80
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YOR211C 12.42
MGM1
Mitochondrial GTPase related to dynamin, present in a complex containing Ugo1p and Fzo1p; required for normal morphology of cristae and for stability of Tim11p; homolog of human OPA1 involved in autosomal dominant optic atrophy
YNL202W 12.32
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YLR136C 11.77
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YBR072W 11.74
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YPL271W 11.72
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YFL052W 11.64 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YMR056C 11.58
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YOR381W 11.39
FRE3
Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YJR155W 11.02
AAD10
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YAR069C 11.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR055C 11.00
CUP1-2
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YGL255W 10.97
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YBR200W-A 10.92 Putative protein of unknown function; identified by fungal homology and RT-PCR
YLR308W 10.86
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YHR015W 10.76
MIP6
Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export
YPL027W 10.65
SMA1
Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YAR050W 10.52
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YJL043W 10.51 Putative protein of unknown function; YJL043W is a non-essential gene
YAR070C 10.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR054W-A 10.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2
YDL114W 10.43 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YMR279C 10.26 Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YGR142W 10.24
BTN2
v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase
YPL033C 10.16 Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p
YEL059W 10.11 Dubious open reading frame unlikely to encode a functional protein
YBR035C 10.08
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YKR033C 10.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YGR088W 9.98
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YKR015C 9.97 Putative protein of unknown function
YAL018C 9.87 Putative protein of unknown function
YLL005C 9.84
SPO75
Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis
YFL012W 9.83 Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin
YOR347C 9.53
PYK2
Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux
YMR141C 9.43 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR540C 9.40
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOL118C 9.26 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGL138C 9.19 Putative protein of unknown function; has no significant sequence similarity to any known protein
YOL084W 8.99
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YER106W 8.91
MAM1
Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle
YPR191W 8.84
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YER085C 8.67 Putative protein of unknown function
YOR346W 8.61
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YHR211W 8.57
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YAR047C 8.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR201C-A 8.49 Putative protein of unknown function
YMR272C 8.46
SCS7
Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth
YDR310C 8.36
SUM1
Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint
YGL170C 8.29
SPO74
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YPR013C 8.27 Putative zinc finger protein; YPR013C is not an essential gene
YOL060C 8.16
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YOR345C 8.15 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YNR063W 8.14 Putative zinc-cluster protein of unknown function
YDL224C 8.13
WHI4
Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
YGR236C 8.06
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL066W 8.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL018C 7.89 Putative protein of unknown function
YJR077C 7.84
MIR1
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
YOR339C 7.82
UBC11
Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2
YCR007C 7.73 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YDR022C 7.73
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YLR054C 7.70
OSW2
Protein of unknown function proposed to be involved in the assembly of the spore wall
YJL213W 7.62 Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p
YOR255W 7.61
OSW1
Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p
YKL163W 7.55
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YJL116C 7.43
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YOR173W 7.39
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YBR250W 7.36
SPO23
Protein of unknown function; associates with meiosis-specific protein Spo1p
YFL030W 7.21
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YGR191W 7.18
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YLR111W 7.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAR068W 7.00 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YKL161C 6.96 Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; associates with Rlm1p
YLR213C 6.87
CRR1
Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
YJR128W 6.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YBR148W 6.67
YSW1
Protein expressed specifically in spores
YIL108W 6.66 Putative metalloprotease
YIR027C 6.61
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YPR054W 6.57
SMK1
Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
YGL180W 6.54
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YOL047C 6.48 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL015C 6.47 Hypothetical protein
YDR034C 6.43
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YOR242C 6.42
SSP2
Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis
YGR043C 6.41
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YOR343C 6.22 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKR016W 6.19
AIM28
Protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss and severe growth defect in minimal glycerol media
YDR281C 6.12
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YEL009C-A 6.11 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER088C 6.10
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YOL119C 6.04
MCH4
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YMR107W 5.93
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YOL132W 5.88
GAS4
1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall
YMR081C 5.86
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YJR151C 5.85
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YDR043C 5.85
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YMR232W 5.83
FUS2
Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating
YDR317W 5.81
HIM1
Protein of unknown function involved in DNA repair
YGR190C 5.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YPL187W 5.78
MF(ALPHA)1
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YEL074W 5.78 Hypothetical protein
YDL169C 5.72
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YGR273C 5.70 Putative protein of unknown function; deletion mutant has no readily detectable phenotype; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation
YPR196W 5.70 Putative maltose activator
YHR054C 5.66 Putative protein of unknown function
YOR227W 5.64 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR190W 5.58
SPR1
Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
YNL034W 5.54 Putative protein of unknown function; YNL034W is not an essential gene
YNR034W 5.52
SOL1
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p
YNR047W 5.52 Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate
YBR180W 5.50
DTR1
Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters
YCR011C 5.48
ADP1
Putative ATP-dependent permease of the ABC transporter family of proteins
YBR179C 5.41
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YER103W 5.38
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YFR047C 5.34
BNA6
Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YOR065W 5.32
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YIL140W 5.30
AXL2
Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
YBR045C 5.27
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YPR015C 5.24 Putative protein of unknown function
YJL130C 5.20
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YNL328C 5.20
MDJ2
Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain
YNR034W-A 5.18 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YHR145C 5.13 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL039C 5.12
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YMR194C-B 4.95 Putative protein of unknown function
YBR039W 4.95
ATP3
Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YMR271C 4.94
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YHR206W 4.92
SKN7
Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation
YEL075C 4.87 Putative protein of unknown function
YFL012W-A 4.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C
YGR260W 4.81
TNA1
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YFL013C 4.81
IES1
Subunit of the INO80 chromatin remodeling complex
YER166W 4.81
DNF1
Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
YDR273W 4.78
DON1
Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II
YGL117W 4.71 Putative protein of unknown function
YCL038C 4.69
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YOL085W-A 4.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YER142C 4.65
MAG1
3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired
YHL016C 4.64
DUR3
Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway
YOR213C 4.58
SAS5
Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
YOL024W 4.53 Putative protein of unknown function, predicted to have thiol-disulfide oxidoreductase active site
YPL261C 4.50 Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W
YPL021W 4.48
ECM23
Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p
YPR005C 4.42
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YJR107W 4.42 Putative protein of unknown function; has sequence or structural similarity to lipases
YBR255C-A 4.41 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YEL010W 4.40 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR040C 4.40 Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential
YGL072C 4.39 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YCR021C 4.33
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YNL196C 4.22
SLZ1
Sporulation-specific protein with a leucine zipper motif
YLL053C 4.20 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YBR021W 4.19
FUR4
Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues

Network of associatons between targets according to the STRING database.

First level regulatory network of SUM1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
15.0 45.1 GO:0019676 ammonia assimilation cycle(GO:0019676)
11.4 34.1 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
8.1 48.5 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
7.7 30.9 GO:0015847 putrescine transport(GO:0015847)
6.8 61.4 GO:0006097 glyoxylate cycle(GO:0006097)
6.7 26.9 GO:0046688 response to copper ion(GO:0046688)
5.2 15.6 GO:0015888 thiamine transport(GO:0015888)
4.6 23.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
4.4 22.0 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
4.2 16.7 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
4.0 31.7 GO:0045740 positive regulation of DNA replication(GO:0045740)
3.6 17.8 GO:0008053 mitochondrial fusion(GO:0008053)
3.3 10.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
3.2 28.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
3.0 30.4 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
2.9 11.6 GO:0015886 heme transport(GO:0015886)
2.6 13.0 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
2.4 101.8 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
2.4 21.8 GO:0000755 cytogamy(GO:0000755)
2.4 7.2 GO:0006545 glycine biosynthetic process(GO:0006545)
2.4 12.0 GO:0015793 glycerol transport(GO:0015793)
2.4 7.2 GO:0045117 azole transport(GO:0045117)
1.9 5.8 GO:1900460 biofilm formation(GO:0042710) negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.9 5.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
1.9 1.9 GO:0043902 positive regulation of multi-organism process(GO:0043902)
1.8 14.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.7 13.8 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
1.7 5.1 GO:0000304 response to singlet oxygen(GO:0000304)
1.7 5.1 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.7 18.7 GO:0006817 phosphate ion transport(GO:0006817)
1.7 8.5 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
1.7 5.0 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.7 40.0 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
1.6 15.9 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
1.6 1.6 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.6 4.7 GO:0006285 base-excision repair, AP site formation(GO:0006285)
1.5 26.2 GO:0009062 fatty acid catabolic process(GO:0009062)
1.5 13.7 GO:0031167 rRNA methylation(GO:0031167)
1.5 21.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
1.5 4.4 GO:0042148 strand invasion(GO:0042148)
1.5 8.8 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
1.4 10.1 GO:0008614 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
1.4 5.7 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
1.4 1.4 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
1.3 6.7 GO:0032108 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
1.3 6.4 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
1.3 2.5 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
1.2 9.9 GO:0015891 siderophore transport(GO:0015891)
1.2 7.3 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
1.2 10.5 GO:0006829 zinc II ion transport(GO:0006829)
1.2 3.5 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
1.1 8.9 GO:0051177 meiotic sister chromatid cohesion(GO:0051177)
1.1 4.3 GO:0015855 pyrimidine nucleobase transport(GO:0015855)
1.0 4.1 GO:0006848 pyruvate transport(GO:0006848)
1.0 8.7 GO:0045332 phospholipid translocation(GO:0045332)
0.9 5.7 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.9 4.7 GO:0044746 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.9 1.8 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.9 10.0 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.9 8.0 GO:0070987 error-free translesion synthesis(GO:0070987)
0.8 1.7 GO:0010942 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
0.8 2.5 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.8 5.0 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.8 2.5 GO:0043270 positive regulation of ion transport(GO:0043270)
0.8 1.6 GO:0061395 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243)
0.8 1.6 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.8 5.5 GO:0000409 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
0.8 15.0 GO:0001101 response to acid chemical(GO:0001101)
0.7 6.7 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.7 3.0 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.7 2.2 GO:0006183 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.7 2.1 GO:0006089 lactate metabolic process(GO:0006089)
0.7 6.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.7 32.3 GO:0034293 sexual sporulation(GO:0034293) sexual sporulation resulting in formation of a cellular spore(GO:0043935)
0.7 2.7 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.6 6.5 GO:0051181 cofactor transport(GO:0051181)
0.6 1.9 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.6 7.7 GO:0007120 axial cellular bud site selection(GO:0007120)
0.6 1.9 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.6 1.8 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.6 3.0 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.6 8.5 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.6 1.8 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.6 5.9 GO:0006826 iron ion transport(GO:0006826)
0.6 2.4 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.6 1.2 GO:0019627 urea metabolic process(GO:0019627)
0.6 1.7 GO:0042843 D-xylose catabolic process(GO:0042843)
0.6 14.9 GO:0006312 mitotic recombination(GO:0006312)
0.5 4.9 GO:0015802 basic amino acid transport(GO:0015802)
0.5 3.2 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)
0.5 1.0 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.5 10.0 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.5 7.5 GO:0006513 protein monoubiquitination(GO:0006513)
0.5 1.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.5 0.5 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.5 6.4 GO:0007129 synapsis(GO:0007129)
0.4 3.1 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.4 9.1 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 1.2 GO:0032186 cellular bud neck septin ring organization(GO:0032186) protein autoubiquitination(GO:0051865) protein localization to bud neck(GO:0097271)
0.4 0.4 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.4 17.9 GO:0030435 sporulation resulting in formation of a cellular spore(GO:0030435) anatomical structure formation involved in morphogenesis(GO:0048646)
0.4 6.0 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.4 2.4 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.4 1.2 GO:0051180 vitamin transport(GO:0051180)
0.4 2.6 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.4 0.7 GO:0044070 regulation of anion transport(GO:0044070)
0.4 11.8 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.4 1.5 GO:0019346 transsulfuration(GO:0019346)
0.4 8.6 GO:0006885 regulation of pH(GO:0006885)
0.4 1.8 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.3 1.4 GO:0019218 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.3 7.1 GO:0031503 protein complex localization(GO:0031503)
0.3 1.3 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.3 1.6 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.3 0.6 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 1.3 GO:0070988 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.3 0.9 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.3 4.2 GO:0000902 cell morphogenesis(GO:0000902)
0.3 0.9 GO:0006598 polyamine catabolic process(GO:0006598)
0.3 1.1 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.3 0.5 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.3 3.9 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.3 0.5 GO:0071456 cellular response to hypoxia(GO:0071456)
0.2 5.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 0.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.2 1.0 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.2 0.9 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.2 2.8 GO:0019740 nitrogen utilization(GO:0019740)
0.2 5.1 GO:0000282 cellular bud site selection(GO:0000282) cytokinesis, site selection(GO:0007105) mitotic cytokinesis, site selection(GO:1902408)
0.2 0.7 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 2.3 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.2 0.7 GO:0090282 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.2 0.9 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.2 0.4 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 0.9 GO:0071168 protein localization to chromatin(GO:0071168)
0.2 1.5 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.2 0.2 GO:0042542 response to hydrogen peroxide(GO:0042542)
0.2 0.4 GO:0006740 NADPH regeneration(GO:0006740)
0.2 3.1 GO:0007266 Rho protein signal transduction(GO:0007266)
0.2 4.0 GO:0008361 regulation of cell size(GO:0008361)
0.2 1.0 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.2 1.2 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.2 0.8 GO:0032581 ER-dependent peroxisome organization(GO:0032581) peroxisome inheritance(GO:0045033)
0.2 1.0 GO:0000023 maltose metabolic process(GO:0000023)
0.2 0.4 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 1.0 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.2 0.2 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.2 0.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.2 1.0 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.2 7.1 GO:0009060 aerobic respiration(GO:0009060)
0.2 2.4 GO:0030474 spindle pole body duplication(GO:0030474)
0.2 0.6 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.2 2.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 2.4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 0.9 GO:0048478 replication fork protection(GO:0048478)
0.1 0.7 GO:0018904 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.1 1.5 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.1 0.5 GO:0071495 cellular response to endogenous stimulus(GO:0071495)
0.1 0.6 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 1.5 GO:0000147 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.9 GO:0000266 mitochondrial fission(GO:0000266)
0.1 1.4 GO:0034968 histone lysine methylation(GO:0034968)
0.1 1.0 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.1 0.5 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.6 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.1 0.6 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.1 1.7 GO:0034401 chromatin organization involved in regulation of transcription(GO:0034401)
0.1 0.2 GO:0009268 response to pH(GO:0009268)
0.1 1.0 GO:0060261 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 0.3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
0.1 0.3 GO:0000042 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 1.8 GO:0009267 cellular response to starvation(GO:0009267)
0.1 0.3 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.4 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.1 0.2 GO:0019748 secondary metabolic process(GO:0019748)
0.1 1.0 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.1 0.8 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.1 GO:0001120 DNA-templated transcriptional open complex formation(GO:0001112) protein-DNA complex remodeling(GO:0001120) macromolecular complex remodeling(GO:0034367)
0.1 0.7 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 0.3 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 0.2 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.1 0.5 GO:0042766 nucleosome mobilization(GO:0042766)
0.1 0.5 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.5 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.5 GO:0030952 establishment or maintenance of actin cytoskeleton polarity(GO:0030950) establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.3 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.0 0.4 GO:0046173 polyol biosynthetic process(GO:0046173)
0.0 0.1 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.2 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.0 0.4 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0036257 multivesicular body organization(GO:0036257)
0.0 0.1 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.3 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.5 GO:0006476 protein deacetylation(GO:0006476) protein deacylation(GO:0035601) macromolecule deacylation(GO:0098732)
0.0 0.3 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.0 0.9 GO:0000082 G1/S transition of mitotic cell cycle(GO:0000082) cell cycle G1/S phase transition(GO:0044843)
0.0 0.2 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.4 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 2.2 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.3 GO:0045727 positive regulation of cellular amide metabolic process(GO:0034250) positive regulation of translation(GO:0045727)
0.0 0.1 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.2 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.0 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.3 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 21.3 GO:0030061 mitochondrial crista(GO:0030061)
5.6 16.7 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
4.3 13.0 GO:0072687 meiotic spindle(GO:0072687)
3.7 44.0 GO:0031160 spore wall(GO:0031160)
3.3 29.6 GO:0045277 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
2.7 19.0 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
2.3 9.1 GO:0033551 monopolin complex(GO:0033551)
2.3 27.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
2.2 6.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
2.0 48.1 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
1.9 5.8 GO:0051286 cell tip(GO:0051286)
1.6 4.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.5 4.6 GO:0033255 SAS acetyltransferase complex(GO:0033255)
1.4 2.8 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.2 2.4 GO:0032126 eisosome(GO:0032126)
1.2 56.8 GO:0031225 anchored component of membrane(GO:0031225)
1.1 27.3 GO:0005887 integral component of plasma membrane(GO:0005887)
1.0 3.0 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.9 3.6 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.9 2.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.9 16.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.8 5.0 GO:0008180 COP9 signalosome(GO:0008180)
0.8 8.6 GO:0005769 early endosome(GO:0005769)
0.8 2.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.7 5.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.7 2.0 GO:0005784 Sec61 translocon complex(GO:0005784)
0.7 2.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.7 5.3 GO:0070069 cytochrome complex(GO:0070069)
0.6 11.0 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.6 1.8 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.6 32.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.5 2.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.5 1.6 GO:0035649 Nrd1 complex(GO:0035649)
0.5 1.5 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.5 22.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.5 8.7 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.5 3.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.5 1.8 GO:0033309 SBF transcription complex(GO:0033309)
0.5 4.1 GO:0000795 synaptonemal complex(GO:0000795)
0.4 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.4 6.5 GO:0033698 Rpd3L complex(GO:0033698)
0.4 1.2 GO:0032177 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.4 0.7 GO:0030478 actin cap(GO:0030478)
0.3 2.4 GO:0034657 GID complex(GO:0034657)
0.3 2.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.3 29.1 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.3 1.0 GO:0000815 ESCRT III complex(GO:0000815)
0.3 6.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 2.7 GO:0030014 CCR4-NOT complex(GO:0030014)
0.2 1.5 GO:0034967 Set3 complex(GO:0034967)
0.2 85.5 GO:0005886 plasma membrane(GO:0005886)
0.2 1.0 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.2 3.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 2.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 0.8 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.1 5.1 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 0.6 GO:0000974 Prp19 complex(GO:0000974)
0.1 0.6 GO:0071007 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.1 7.6 GO:0005815 microtubule organizing center(GO:0005815) spindle pole body(GO:0005816)
0.1 3.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 2.1 GO:0070847 core mediator complex(GO:0070847)
0.1 0.3 GO:0030869 RENT complex(GO:0030869)
0.1 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.4 GO:0016587 Isw1 complex(GO:0016587)
0.1 0.5 GO:0016272 prefoldin complex(GO:0016272)
0.1 3.4 GO:0005643 nuclear pore(GO:0005643)
0.1 8.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 2.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.4 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 3.4 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 13.1 GO:0005739 mitochondrion(GO:0005739)
0.0 0.3 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 1.1 GO:0043332 mating projection tip(GO:0043332)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.0 GO:0034518 RNA cap binding complex(GO:0034518)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
14.4 43.2 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
12.1 48.5 GO:0005537 mannose binding(GO:0005537)
11.4 34.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
11.3 45.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
10.5 31.5 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
6.2 37.0 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
5.3 15.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
4.9 14.7 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
4.3 26.0 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
4.2 16.7 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
4.1 24.9 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
3.7 14.8 GO:0015295 solute:proton symporter activity(GO:0015295)
3.3 13.3 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
3.0 29.6 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
3.0 11.8 GO:0005471 ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
2.6 15.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
2.4 7.2 GO:1901474 azole transmembrane transporter activity(GO:1901474)
2.2 6.7 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
2.2 15.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.2 10.8 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
2.2 8.6 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
2.0 10.1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
2.0 13.8 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.9 14.9 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
1.8 19.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.7 10.4 GO:0016408 C-acyltransferase activity(GO:0016408)
1.7 15.2 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
1.7 6.7 GO:0000772 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
1.6 6.4 GO:0015294 solute:cation symporter activity(GO:0015294)
1.5 3.0 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
1.5 5.9 GO:0000156 phosphorelay response regulator activity(GO:0000156)
1.4 4.3 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.4 5.5 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
1.4 11.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.3 4.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.3 6.6 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
1.3 5.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.3 11.4 GO:0000149 SNARE binding(GO:0000149)
1.2 7.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.1 3.4 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.1 8.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.1 3.2 GO:0015385 sodium:proton antiporter activity(GO:0015385)
1.0 1.0 GO:0015151 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.0 6.0 GO:0015293 symporter activity(GO:0015293)
1.0 4.0 GO:0004396 hexokinase activity(GO:0004396)
1.0 8.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.9 4.7 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.9 4.6 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.9 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.9 16.9 GO:0050661 NADP binding(GO:0050661)
0.8 6.5 GO:0051184 cofactor transporter activity(GO:0051184)
0.8 2.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.8 5.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.8 4.0 GO:0004707 MAP kinase activity(GO:0004707)
0.8 3.2 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.8 3.9 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.8 6.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.8 4.5 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.7 11.3 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.7 2.1 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.7 12.5 GO:0019213 deacetylase activity(GO:0019213)
0.6 1.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.6 5.8 GO:0001671 ATPase activator activity(GO:0001671)
0.6 1.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 1.7 GO:0032183 SUMO binding(GO:0032183)
0.6 1.2 GO:0051183 vitamin transporter activity(GO:0051183)
0.5 8.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 1.5 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.5 7.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.5 4.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.5 1.4 GO:0033592 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.5 1.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.4 1.3 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.4 2.9 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 1.2 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.4 1.6 GO:0016531 copper chaperone activity(GO:0016531)
0.4 6.1 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.4 1.9 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 2.2 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.3 1.4 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.3 2.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 2.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 2.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 2.0 GO:0005244 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.3 0.9 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.3 1.5 GO:0017048 Rho GTPase binding(GO:0017048)
0.3 3.9 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.3 1.8 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.3 2.0 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.3 7.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.3 1.1 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.3 0.9 GO:0000150 recombinase activity(GO:0000150)
0.3 2.5 GO:0030246 carbohydrate binding(GO:0030246)
0.3 3.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.3 4.8 GO:0101005 thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.3 0.8 GO:0004457 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 4.2 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.2 0.5 GO:0005102 receptor binding(GO:0005102)
0.2 17.0 GO:0051082 unfolded protein binding(GO:0051082)
0.2 0.9 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 0.6 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 4.3 GO:0005509 calcium ion binding(GO:0005509)
0.2 0.6 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.2 0.6 GO:0016417 S-acyltransferase activity(GO:0016417)
0.2 1.4 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.2 1.5 GO:0010181 FMN binding(GO:0010181)
0.2 6.7 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405)
0.2 0.5 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.2 2.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 2.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 1.8 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.1 16.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 7.2 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.1 0.4 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors(GO:0016903)
0.1 0.7 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 1.6 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.1 0.4 GO:0070336 flap-structured DNA binding(GO:0070336)
0.1 0.5 GO:0008171 O-methyltransferase activity(GO:0008171)
0.1 0.5 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.1 3.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.6 GO:0016783 sulfurtransferase activity(GO:0016783)
0.1 0.6 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.5 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.1 1.0 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.0 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.7 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 2.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.1 0.2 GO:0004180 carboxypeptidase activity(GO:0004180)
0.1 0.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.1 0.2 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.7 GO:0043022 ribosome binding(GO:0043022)
0.0 0.2 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 2.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.4 GO:0008236 serine-type peptidase activity(GO:0008236)
0.0 0.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0 0.1 GO:0001034 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.1 GO:0030276 clathrin binding(GO:0030276)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.8 PID IL4 2PATHWAY IL4-mediated signaling events
2.4 7.2 PID AR PATHWAY Coregulation of Androgen receptor activity
2.0 6.1 PID ERBB4 PATHWAY ErbB4 signaling events
1.2 2.4 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.9 0.9 PID ERBB1 RECEPTOR PROXIMAL PATHWAY EGF receptor (ErbB1) signaling pathway
0.9 1.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.4 581.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.3 1.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 0.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 14.6 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
2.3 7.0 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
1.4 1.4 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.9 2.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.9 0.9 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.9 0.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.4 1.8 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.4 1.7 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.4 3.9 REACTOME DNA REPAIR Genes involved in DNA Repair
0.4 3.4 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.4 567.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.3 0.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 0.8 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.1 0.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.2 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.2 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.0 0.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein