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Results for STE12

Z-value: 2.89

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Transcription factors associated with STE12

Gene Symbol Gene ID Gene Info
STE12
S000001126 Transcription factor that is activated by a MAPK signaling cascade

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STE12YHR084W0.653.1e-04Click!

Activity profile of STE12 motif

Sorted Z-values of STE12 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YCR018C 29.01
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YGR108W 26.20
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YFR055W 22.54
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 20.34 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YPR119W 19.81
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YLR154C 19.68
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YIL052C 19.39
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YGL097W 18.41
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YLL045C 18.30
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YDR044W 17.56
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YER102W 16.92
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YNR054C 16.03
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YLR154W-A 15.52 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154W-B 15.27 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YHR084W 14.66
STE12
Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth
YCL055W 14.27
KAR4
Transcription factor required for gene regulation in repsonse to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone
YDR279W 13.96
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YGR040W 13.70
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YLR061W 12.52
RPL22A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein
YNL043C 12.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YIR021W 11.65
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YHR181W 11.63
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YDL055C 11.52
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YOR096W 11.47
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YKL096W-A 11.18
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YHR141C 10.62
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YFL026W 10.46
STE2
Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells
YNR044W 10.42
AGA1
Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds
YEL068C 10.12 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL040W 9.98
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YKR041W 9.81 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YLR154W-C 9.75
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YIL015W 9.51
BAR1
Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YNR001W-A 9.20 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YKL218C 8.98
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YDR033W 8.97
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YPL075W 8.93
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YBR158W 8.88
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YGR085C 8.80
RPL11B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YML046W 8.78
PRP39
U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
YIL009W 8.70
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YDR099W 8.55
BMH2
14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YHR180W-A 8.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YHR005C 8.05
GPA1
GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome
YPR170W-B 8.01 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YDR098C 7.91
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YOL039W 7.84
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YHR201C 7.68
PPX1
Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix
YLR388W 7.67
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YCR019W 7.64
MAK32
Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YPL250W-A 7.63 Identified by fungal homology and RT-PCR
YLR257W 7.56 Putative protein of unknown function
YJL169W 7.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
YHR010W 7.46
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YPL163C 7.34
SVS1
Cell wall and vacuolar protein, required for wild-type resistance to vanadate
YOL040C 7.30
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YGR027C 7.27
RPS25A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YLR452C 7.27
SST2
GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family
YLR411W 7.25
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YCL027W 7.18
FUS1
Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate
YKL164C 7.16
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YEL066W 7.05
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YPL273W 7.00
SAM4
S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YLR349W 6.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YPR170W-A 6.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YKL110C 6.82
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YDR278C 6.75 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL009C-A 6.74
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YLR448W 6.67
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YLR348C 6.66
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YOL101C 6.65
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YKR092C 6.42
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YHL015W 6.40
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YER137C 6.36 Putative protein of unknown function
YJL157C 6.19
FAR1
Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate
YJL107C 6.19 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YBL072C 6.13
RPS8A
Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein
YER074W 6.12
RPS24A
Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein
YNL302C 6.10
RPS19B
Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap
YGL201C 6.05
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YGR189C 5.95
CRH1
Putative chitin transglycosidase, cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; localizes to sites of polarized growth; expression is induced under cell wall stress conditions
YDR345C 5.94
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YFR031C-A 5.93
RPL2A
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YEL067C 5.89 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR171W 5.88
BSP1
Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YNL280C 5.87
ERG24
C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions
YOR342C 5.76 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YER001W 5.76
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YER131W 5.75
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YOR212W 5.75
STE4
G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats
YNL153C 5.74
GIM3
Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
YPL142C 5.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YJL188C 5.63
BUD19
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YNR067C 5.63
DSE4
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
YKL209C 5.60
STE6
Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells
YGR106C 5.56
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YOL161C 5.42
PAU20
Hypothetical protein
YPL141C 5.38 Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL141C is not an essential gene
YKR013W 5.35
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YFR054C 5.27 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL018W 5.18
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway
YOR181W 5.17
LAS17
Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)
YMR205C 5.14
PFK2
Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
YFL027C 5.13
GYP8
GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
YLR042C 5.13 Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene
YMR183C 5.13
SSO2
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YOR180C 5.11
DCI1
Peroxisomal delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, involved in fatty acid metabolism, contains peroxisome targeting signals at amino and carboxy termini
YPR014C 5.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene
YKL122C 5.06
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YBR092C 5.05
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YPR170C 5.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YIL053W 5.02
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YGR208W 4.96
SER2
Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
YLR150W 4.89
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YAR071W 4.84
PHO11
One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YOR226C 4.83
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YEL001C 4.82
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YJR009C 4.75
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YGL032C 4.69
AGA2
Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
YHR143W 4.69
DSE2
Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YJL105W 4.66
SET4
Protein of unknown function, contains a SET domain
YGR107W 4.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR339C 4.63
FCF1
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p
YHR144C 4.57
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YJL106W 4.55
IME2
Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
YJL190C 4.52
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YKR012C 4.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YNL141W 4.45
AAH1
Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome
YGR242W 4.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YBR023C 4.42
CHS3
Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YGR293C 4.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YDR002W 4.41
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YHR030C 4.39
SLT2
Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
YJL158C 4.39
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YNL066W 4.34
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YDL228C 4.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1
YLR068W 4.32
FYV7
Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in processing the 35S rRNA primary transcript to generate the 20S and 27SA2 pre-rRNA transcripts
YOL121C 4.31
RPS19A
Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp
YLR292C 4.30
SEC72
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YKL182W 4.22
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YER007C-A 4.22
TMA20
Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1
YKR038C 4.20
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YJR123W 4.16
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YKL153W 4.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
YHR203C 4.16
RPS4B
Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein
YIL123W 4.12
SIM1
Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
YDL211C 4.11 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YIL018W 4.10
RPL2B
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures
YER048C 4.10
CAJ1
Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YMR049C 4.08
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YOR108C-A 4.07 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YMR305C 4.05
SCW10
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
YOR101W 4.05
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YMR003W 4.04
AIM34
Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YGR279C 4.02
SCW4
Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating
YDR133C 4.02 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YLR455W 3.97 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YML074C 3.97
FPR3
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YBR181C 3.96
RPS6B
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YGL253W 3.95
HXK2
Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene
YBR283C 3.94
SSH1
Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential
YDR417C 3.93 Hypothetical protein
YDL132W 3.92
CDC53
Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation
YLL043W 3.91
FPS1
Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
YPL177C 3.81
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YGR123C 3.81
PPT1
Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YGR241C 3.80
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YDR261C 3.79
EXG2
Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YCR006C 3.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL008W 3.77
URM1
Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YPL050C 3.75
MNN9
Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation
YJL115W 3.74
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YMR198W 3.74
CIK1
Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p
YGR214W 3.74
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YCR034W 3.73
FEN1
Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway
YNL178W 3.73
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YER073W 3.68
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YER048W-A 3.65
ISD11
Protein required for mitochondrial iron-sulfur cluster biosynthesis
YLR286C 3.64
CTS1
Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YJL011C 3.63
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YDR183C-A 3.63 Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR
YPR010C 3.63
RPA135
RNA polymerase I subunit A135
YMR072W 3.61
ABF2
Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
YDR381W 3.61
YRA1
Nuclear protein that binds to RNA and to Mex67p, required for export of poly(A)+ mRNA from the nucleus; member of the REF (RNA and export factor binding proteins) family; another family member, Yra2p, can substitute for Yra1p function
YDL240W 3.60
LRG1
Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis
YGL147C 3.59
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YPL239W 3.58
YAR1
Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YML063W 3.58
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YER070W 3.56
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YNL079C 3.56
TPM1
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YLR210W 3.55
CLB4
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation
YJR054W 3.55 Vacuolar protein of unknown function; potential Cdc28p substrate
YPL131W 3.54
RPL5
Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YDR471W 3.54
RPL27B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YDR091C 3.54
RLI1
Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase
YPL112C 3.51
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YGR251W 3.51 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YPL220W 3.48
RPL1A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YKL219W 3.48
COS9
Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YGL148W 3.46
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids

Network of associatons between targets according to the STRING database.

First level regulatory network of STE12

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 21.9 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
6.9 48.1 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
5.3 31.5 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
5.2 36.5 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
4.9 14.7 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
3.8 11.5 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
3.7 14.8 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
3.5 63.7 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
3.2 16.2 GO:0000028 ribosomal small subunit assembly(GO:0000028)
3.2 22.2 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
3.1 9.2 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
2.9 8.6 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
2.8 8.3 GO:0006798 polyphosphate catabolic process(GO:0006798)
2.7 13.5 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
2.6 18.0 GO:0030031 cell projection organization(GO:0030030) cell projection assembly(GO:0030031)
2.5 7.6 GO:0046416 D-amino acid metabolic process(GO:0046416)
2.4 7.2 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
2.1 6.2 GO:2000877 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
2.0 4.1 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
2.0 13.8 GO:0043171 peptide catabolic process(GO:0043171)
2.0 21.6 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
2.0 5.9 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
1.9 3.8 GO:0015909 long-chain fatty acid transport(GO:0015909)
1.9 7.5 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
1.9 26.2 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
1.9 9.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
1.8 254.9 GO:0002181 cytoplasmic translation(GO:0002181)
1.8 9.1 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
1.8 8.9 GO:0050667 homocysteine metabolic process(GO:0050667)
1.7 5.1 GO:0046083 adenine metabolic process(GO:0046083)
1.7 5.0 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
1.6 8.2 GO:0051125 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315) regulation of actin nucleation(GO:0051125)
1.6 9.5 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
1.5 8.8 GO:0043555 regulation of translation in response to stress(GO:0043555)
1.4 11.4 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.4 6.9 GO:0035434 copper ion transmembrane transport(GO:0035434)
1.3 5.2 GO:0098742 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
1.3 5.1 GO:0030497 fatty acid elongation(GO:0030497)
1.3 5.1 GO:0009423 chorismate biosynthetic process(GO:0009423)
1.3 8.8 GO:0006835 dicarboxylic acid transport(GO:0006835)
1.2 3.7 GO:0019413 acetate biosynthetic process(GO:0019413)
1.2 3.6 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
1.2 7.1 GO:0006491 N-glycan processing(GO:0006491)
1.2 1.2 GO:0046417 chorismate metabolic process(GO:0046417)
1.2 4.7 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
1.2 4.7 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990)
1.2 4.6 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
1.1 2.2 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
1.1 6.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
1.1 3.3 GO:0046677 response to antibiotic(GO:0046677)
1.1 5.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.0 10.2 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
1.0 2.0 GO:0006571 tyrosine biosynthetic process(GO:0006571) L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
1.0 10.1 GO:0007021 tubulin complex assembly(GO:0007021)
1.0 1.0 GO:0006282 regulation of DNA repair(GO:0006282)
1.0 3.0 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
1.0 2.0 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
1.0 2.9 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
1.0 3.8 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.9 4.7 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.9 2.8 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.9 2.8 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.9 3.7 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.9 2.7 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.9 2.6 GO:0090220 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.9 4.3 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.9 2.6 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.8 2.5 GO:0099515 actin filament-based movement(GO:0030048) actin filament-based transport(GO:0099515)
0.8 17.5 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.8 1.6 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.8 4.8 GO:0009088 threonine biosynthetic process(GO:0009088)
0.8 7.7 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.8 3.0 GO:0015867 ATP transport(GO:0015867)
0.7 9.0 GO:0007120 axial cellular bud site selection(GO:0007120)
0.7 5.1 GO:0006551 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098)
0.7 10.7 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.7 12.6 GO:0032508 DNA duplex unwinding(GO:0032508)
0.7 3.5 GO:0060304 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.7 3.4 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.7 2.0 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.6 16.9 GO:0006885 regulation of pH(GO:0006885)
0.6 2.6 GO:0015883 FAD transport(GO:0015883)
0.6 1.9 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.6 2.6 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.6 3.8 GO:0043457 regulation of cellular respiration(GO:0043457)
0.6 2.5 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.6 5.0 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.6 4.3 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.6 1.8 GO:0046495 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.6 1.8 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.6 2.4 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.6 8.4 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.6 3.6 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.6 2.3 GO:0000915 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin structure organization(GO:0031032) actomyosin contractile ring organization(GO:0044837)
0.6 2.9 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.6 7.0 GO:0015833 peptide transport(GO:0015833)
0.6 7.0 GO:0006415 translational termination(GO:0006415)
0.6 2.3 GO:0000296 spermine transport(GO:0000296)
0.6 1.7 GO:0007535 donor selection(GO:0007535)
0.6 13.6 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.6 1.7 GO:0015809 arginine transport(GO:0015809)
0.6 5.6 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.5 4.9 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.5 2.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.5 2.7 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.5 3.7 GO:0016559 peroxisome fission(GO:0016559)
0.5 2.6 GO:0043007 maintenance of rDNA(GO:0043007)
0.5 14.5 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472)
0.5 2.6 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.5 2.1 GO:0009636 response to toxic substance(GO:0009636)
0.5 1.5 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.5 14.3 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.5 1.0 GO:0000916 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.5 3.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.5 3.0 GO:0044038 cell wall macromolecule biosynthetic process(GO:0044038) cellular component macromolecule biosynthetic process(GO:0070589)
0.5 2.4 GO:0015677 copper ion import(GO:0015677)
0.5 3.8 GO:0006801 superoxide metabolic process(GO:0006801)
0.5 2.4 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.5 3.8 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.5 17.1 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.5 1.4 GO:0000101 sulfur amino acid transport(GO:0000101)
0.5 2.8 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.5 1.4 GO:0006021 inositol biosynthetic process(GO:0006021)
0.5 1.4 GO:0042710 biofilm formation(GO:0042710)
0.5 2.3 GO:0009073 tryptophan biosynthetic process(GO:0000162) aromatic amino acid family biosynthetic process(GO:0009073) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.5 1.8 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.5 1.4 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.4 2.7 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.4 0.4 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.4 3.5 GO:0034501 protein localization to kinetochore(GO:0034501)
0.4 13.6 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.4 4.4 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.4 3.4 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.4 1.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.4 1.7 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.4 1.6 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.4 2.4 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.4 2.8 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.4 1.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.4 0.8 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.4 4.8 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.4 10.7 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.4 1.1 GO:0045862 positive regulation of proteolysis(GO:0045862)
0.4 46.1 GO:0006364 rRNA processing(GO:0006364)
0.4 0.4 GO:0036260 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
0.4 1.8 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.4 5.6 GO:0030488 tRNA methylation(GO:0030488)
0.4 2.5 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.3 1.7 GO:0006177 GMP biosynthetic process(GO:0006177)
0.3 0.7 GO:0016578 histone deubiquitination(GO:0016578)
0.3 2.4 GO:0034063 stress granule assembly(GO:0034063)
0.3 1.4 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.3 0.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.3 1.4 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.3 8.0 GO:0016129 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.3 0.3 GO:0048194 Golgi vesicle budding(GO:0048194)
0.3 2.9 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.3 1.9 GO:0000921 septin ring assembly(GO:0000921)
0.3 1.3 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.3 1.3 GO:0015939 pantothenate metabolic process(GO:0015939) pantothenate biosynthetic process(GO:0015940)
0.3 4.1 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.3 19.0 GO:0016311 dephosphorylation(GO:0016311)
0.3 0.6 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.3 2.1 GO:0007323 peptide pheromone maturation(GO:0007323)
0.3 1.5 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.3 1.8 GO:0042991 transcription factor import into nucleus(GO:0042991)
0.3 3.8 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 0.9 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.3 4.1 GO:0006446 regulation of translational initiation(GO:0006446)
0.3 3.1 GO:0051666 actin cortical patch localization(GO:0051666)
0.3 1.1 GO:0009099 valine biosynthetic process(GO:0009099)
0.3 2.5 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.3 3.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 2.7 GO:0006273 lagging strand elongation(GO:0006273)
0.3 0.8 GO:0071041 antisense RNA transcript catabolic process(GO:0071041)
0.3 1.0 GO:0043242 negative regulation of protein complex disassembly(GO:0043242)
0.3 0.3 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.2 0.7 GO:0006517 protein deglycosylation(GO:0006517)
0.2 0.9 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.2 7.1 GO:0090174 organelle membrane fusion(GO:0090174)
0.2 3.4 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.2 4.5 GO:0006334 nucleosome assembly(GO:0006334)
0.2 0.4 GO:0045128 negative regulation of reciprocal meiotic recombination(GO:0045128)
0.2 0.4 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.2 2.2 GO:0006448 regulation of translational elongation(GO:0006448)
0.2 3.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 2.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.2 0.8 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.2 0.9 GO:0071265 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.2 0.5 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.2 0.4 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.2 0.2 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.2 0.2 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.2 0.5 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.2 3.2 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.2 1.3 GO:0008298 intracellular mRNA localization(GO:0008298)
0.2 1.1 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.2 0.8 GO:0000733 DNA strand renaturation(GO:0000733)
0.2 1.1 GO:0009306 protein secretion(GO:0009306)
0.2 1.3 GO:0030705 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) cytoskeleton-dependent intracellular transport(GO:0030705) organelle transport along microtubule(GO:0072384)
0.2 2.4 GO:0046785 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.2 0.6 GO:0019358 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.2 0.5 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.2 4.1 GO:0042254 ribosome biogenesis(GO:0042254)
0.2 10.3 GO:0051169 nucleocytoplasmic transport(GO:0006913) nuclear transport(GO:0051169)
0.1 1.6 GO:0006414 translational elongation(GO:0006414)
0.1 3.6 GO:0006413 translational initiation(GO:0006413)
0.1 0.9 GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway(GO:0000947)
0.1 0.9 GO:0030026 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.5 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.4 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 1.3 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.9 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.1 0.4 GO:0034389 lipid particle organization(GO:0034389)
0.1 3.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 2.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.1 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.6 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.7 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 0.6 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 1.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.2 GO:0009249 protein lipoylation(GO:0009249)
0.1 1.4 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.2 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.3 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.1 0.8 GO:0019856 pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1 0.4 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.3 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1 0.4 GO:0051668 localization within membrane(GO:0051668)
0.1 0.3 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 0.8 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 1.3 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 0.2 GO:0035269 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.1 0.6 GO:0051050 positive regulation of transport(GO:0051050)
0.1 0.3 GO:0016574 histone ubiquitination(GO:0016574)
0.1 0.3 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.1 1.7 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.2 GO:0015918 sterol transport(GO:0015918)
0.1 0.1 GO:0051664 nuclear pore distribution(GO:0031081) nuclear pore localization(GO:0051664)
0.1 0.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.4 GO:0048478 replication fork protection(GO:0048478)
0.1 0.2 GO:0036010 protein localization to endosome(GO:0036010)
0.1 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.1 0.6 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 0.5 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.1 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 0.5 GO:0006887 exocytosis(GO:0006887)
0.1 0.3 GO:0006284 base-excision repair(GO:0006284)
0.1 0.3 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 0.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.5 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.0 1.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.2 GO:0070868 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.0 0.2 GO:0070058 tRNA gene clustering(GO:0070058)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.7 GO:0006400 tRNA modification(GO:0006400)
0.0 0.2 GO:0034661 ncRNA catabolic process(GO:0034661)
0.0 0.3 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0072503 cellular divalent inorganic cation homeostasis(GO:0072503) divalent inorganic cation homeostasis(GO:0072507)
0.0 0.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.5 GO:0007015 actin filament organization(GO:0007015)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.0 0.2 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.0 GO:0051785 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446) positive regulation of nuclear division(GO:0051785)
0.0 0.1 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.3 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.0 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.0 GO:0009847 spore germination(GO:0009847)
0.0 0.1 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
11.2 33.6 GO:0032299 ribonuclease H2 complex(GO:0032299)
3.8 11.4 GO:0030428 cell septum(GO:0030428)
3.7 14.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
3.7 29.3 GO:0042597 periplasmic space(GO:0042597)
2.2 183.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.1 128.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
1.7 3.4 GO:0044453 nuclear membrane part(GO:0044453)
1.6 4.7 GO:0000229 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
1.5 24.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.4 7.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.4 4.2 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
1.4 4.1 GO:0070545 PeBoW complex(GO:0070545)
1.4 4.1 GO:0000814 ESCRT II complex(GO:0000814)
1.3 12.1 GO:0000144 cellular bud neck septin ring(GO:0000144)
1.3 3.9 GO:0071261 Ssh1 translocon complex(GO:0071261)
1.2 5.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
1.2 3.6 GO:0097344 Rix1 complex(GO:0097344)
1.2 8.3 GO:0016272 prefoldin complex(GO:0016272)
1.1 6.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
1.1 11.8 GO:0000243 commitment complex(GO:0000243)
1.0 8.4 GO:0051233 spindle midzone(GO:0051233)
1.0 3.1 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
1.0 6.0 GO:0032040 small-subunit processome(GO:0032040)
1.0 3.9 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
1.0 5.9 GO:0042555 MCM complex(GO:0042555)
1.0 6.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.9 6.6 GO:0032432 actin filament bundle(GO:0032432)
0.9 3.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.9 20.6 GO:0030173 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.8 9.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.8 2.4 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.8 5.4 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.8 3.8 GO:0032545 CURI complex(GO:0032545)
0.7 3.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.7 2.9 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.7 11.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.7 2.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.7 4.3 GO:0005871 kinesin complex(GO:0005871)
0.6 9.1 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.6 3.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.6 1.9 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 4.3 GO:0000346 transcription export complex(GO:0000346)
0.6 0.6 GO:0005880 nuclear microtubule(GO:0005880)
0.6 13.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.6 8.0 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.5 28.9 GO:0030686 90S preribosome(GO:0030686)
0.5 2.1 GO:0033551 monopolin complex(GO:0033551)
0.5 1.6 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.5 0.5 GO:0030689 Noc complex(GO:0030689)
0.5 1.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.5 1.5 GO:0030869 RENT complex(GO:0030869)
0.5 26.3 GO:0000131 incipient cellular bud site(GO:0000131)
0.5 7.0 GO:0000786 nucleosome(GO:0000786)
0.5 1.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 1.0 GO:0033309 SBF transcription complex(GO:0033309)
0.5 1.0 GO:0016363 nuclear matrix(GO:0016363)
0.5 63.2 GO:0005933 cellular bud(GO:0005933)
0.5 0.5 GO:0071819 DUBm complex(GO:0071819)
0.5 1.4 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.5 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 2.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.4 6.5 GO:0005576 extracellular region(GO:0005576)
0.4 2.8 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.4 0.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.4 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 2.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 3.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.4 1.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4 1.4 GO:0030907 MBF transcription complex(GO:0030907)
0.4 2.1 GO:0072686 mitotic spindle(GO:0072686)
0.3 1.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.3 1.0 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.3 4.0 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 1.0 GO:0070985 TFIIK complex(GO:0070985)
0.3 1.3 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.3 4.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 0.3 GO:0000145 exocyst(GO:0000145)
0.3 1.5 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.3 0.9 GO:0070939 Dsl1p complex(GO:0070939)
0.3 2.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 1.7 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.3 0.9 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 2.0 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.3 1.4 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.3 1.1 GO:0030867 rough endoplasmic reticulum(GO:0005791) rough endoplasmic reticulum membrane(GO:0030867)
0.3 1.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.3 5.2 GO:0031201 SNARE complex(GO:0031201)
0.3 1.8 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.3 9.7 GO:0043332 mating projection tip(GO:0043332)
0.3 1.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.3 53.6 GO:0005829 cytosol(GO:0005829)
0.3 1.5 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.2 6.0 GO:0005844 polysome(GO:0005844)
0.2 4.5 GO:0016586 RSC complex(GO:0016586)
0.2 0.7 GO:0022624 proteasome regulatory particle(GO:0005838) proteasome accessory complex(GO:0022624)
0.2 2.2 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 4.9 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.2 2.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 1.8 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 28.8 GO:0005730 nucleolus(GO:0005730)
0.2 0.9 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.2 13.3 GO:0009277 fungal-type cell wall(GO:0009277)
0.2 0.8 GO:0033176 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
0.2 0.6 GO:0016587 Isw1 complex(GO:0016587)
0.2 1.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 0.5 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.2 0.7 GO:0033263 HOPS complex(GO:0030897) CORVET complex(GO:0033263)
0.2 0.8 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.2 3.4 GO:0005840 ribosome(GO:0005840)
0.2 14.1 GO:0005635 nuclear envelope(GO:0005635)
0.1 0.3 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 9.4 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.1 0.4 GO:0070823 HDA1 complex(GO:0070823)
0.1 0.6 GO:0034448 EGO complex(GO:0034448)
0.1 0.4 GO:0034044 exomer complex(GO:0034044)
0.1 0.3 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.9 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.3 GO:0031417 NatC complex(GO:0031417)
0.1 0.7 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 25.3 GO:0005783 endoplasmic reticulum(GO:0005783)
0.1 0.1 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.1 4.3 GO:0000139 Golgi membrane(GO:0000139)
0.1 1.1 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.4 GO:0055087 Ski complex(GO:0055087)
0.1 0.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.2 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.7 GO:0036452 ESCRT complex(GO:0036452)
0.1 0.9 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.1 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.2 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.5 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 10.3 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.7 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.4 GO:0000502 proteasome complex(GO:0000502)
0.0 0.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.6 GO:0005657 replication fork(GO:0005657)
0.0 0.3 GO:0071010 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.0 0.0 GO:0008623 CHRAC(GO:0008623)
0.0 0.0 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.8 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.8 35.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
4.8 19.2 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
3.9 19.5 GO:0004707 MAP kinase activity(GO:0004707)
3.8 11.5 GO:0070568 guanylyltransferase activity(GO:0070568)
3.6 21.4 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
3.1 9.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
2.9 8.6 GO:0051219 phosphoprotein binding(GO:0051219)
2.4 7.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
2.3 11.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
2.2 8.8 GO:0016841 ammonia-lyase activity(GO:0016841)
2.2 6.6 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
2.1 8.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
2.0 6.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
2.0 7.9 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
1.9 9.6 GO:0036002 pre-mRNA binding(GO:0036002)
1.9 43.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.9 5.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
1.8 7.0 GO:0008172 S-methyltransferase activity(GO:0008172)
1.7 5.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
1.7 1.7 GO:0015248 sterol transporter activity(GO:0015248)
1.7 5.1 GO:0009922 fatty acid elongase activity(GO:0009922)
1.7 10.1 GO:0003993 acid phosphatase activity(GO:0003993)
1.5 4.6 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
1.5 4.4 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
1.5 304.9 GO:0003735 structural constituent of ribosome(GO:0003735)
1.4 5.8 GO:0009378 four-way junction helicase activity(GO:0009378)
1.4 4.2 GO:0051010 microtubule plus-end binding(GO:0051010)
1.4 11.0 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
1.3 4.0 GO:0019202 amino acid kinase activity(GO:0019202)
1.3 6.5 GO:0008443 phosphofructokinase activity(GO:0008443)
1.3 3.9 GO:0004930 G-protein coupled receptor activity(GO:0004930)
1.2 3.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
1.1 3.4 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
1.1 15.5 GO:0001671 ATPase activator activity(GO:0001671)
1.1 4.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
1.1 6.6 GO:0008312 7S RNA binding(GO:0008312)
1.1 5.5 GO:0017048 Rho GTPase binding(GO:0017048)
1.1 5.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.1 3.3 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
1.1 3.2 GO:0004100 chitin synthase activity(GO:0004100)
1.1 5.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.0 3.1 GO:0016504 peptidase activator activity(GO:0016504)
1.0 5.2 GO:0008536 Ran GTPase binding(GO:0008536)
1.0 3.1 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
1.0 4.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.0 3.9 GO:0016417 S-acyltransferase activity(GO:0016417)
1.0 5.8 GO:0070300 phosphatidic acid binding(GO:0070300)
1.0 1.9 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
1.0 3.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.9 28.8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.9 6.3 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.9 3.6 GO:0008252 nucleotidase activity(GO:0008252)
0.9 3.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.9 5.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.9 3.5 GO:0008242 omega peptidase activity(GO:0008242)
0.8 3.1 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.8 3.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.8 5.5 GO:0030145 manganese ion binding(GO:0030145)
0.8 6.1 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.8 9.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.7 3.0 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.7 3.6 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.7 5.7 GO:0031490 chromatin DNA binding(GO:0031490)
0.7 2.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.7 2.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.6 9.1 GO:0001054 RNA polymerase I activity(GO:0001054)
0.6 2.6 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.6 4.4 GO:0016778 diphosphotransferase activity(GO:0016778)
0.6 13.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.6 5.6 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.6 8.0 GO:0051015 actin filament binding(GO:0051015)
0.6 5.5 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.6 17.0 GO:0015631 tubulin binding(GO:0015631)
0.6 5.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.6 2.3 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.6 2.3 GO:0005034 osmosensor activity(GO:0005034)
0.6 5.5 GO:0005216 ion channel activity(GO:0005216)
0.5 3.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.5 3.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.5 22.1 GO:0005096 GTPase activator activity(GO:0005096)
0.5 3.0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.5 3.5 GO:0031386 protein tag(GO:0031386)
0.5 1.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.5 6.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.5 3.8 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
0.5 5.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.5 2.4 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.5 1.9 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.5 0.9 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.5 1.4 GO:0016872 intramolecular lyase activity(GO:0016872)
0.5 1.8 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.5 1.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 1.8 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.5 1.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.4 4.4 GO:0019239 deaminase activity(GO:0019239)
0.4 10.2 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.4 1.3 GO:0019003 GDP binding(GO:0019003)
0.4 2.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.4 11.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 3.2 GO:1901681 sulfur compound binding(GO:1901681)
0.4 15.6 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.4 3.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 1.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.4 1.1 GO:0004312 fatty acid synthase activity(GO:0004312)
0.4 3.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.4 1.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.4 0.7 GO:0019842 vitamin binding(GO:0019842)
0.4 5.2 GO:0051087 chaperone binding(GO:0051087)
0.4 1.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.4 0.7 GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding(GO:0001082)
0.3 10.7 GO:0030674 protein binding, bridging(GO:0030674) binding, bridging(GO:0060090)
0.3 1.4 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.3 0.7 GO:0035591 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.3 1.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 7.9 GO:0003779 actin binding(GO:0003779)
0.3 19.4 GO:0003924 GTPase activity(GO:0003924)
0.3 0.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.3 0.9 GO:0003680 AT DNA binding(GO:0003680)
0.3 0.6 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.3 0.9 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.3 5.5 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.3 2.3 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 0.6 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.3 0.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.3 15.1 GO:0008565 protein transporter activity(GO:0008565)
0.3 1.8 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.2 1.7 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.2 1.7 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.2 0.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.2 1.9 GO:0005516 calmodulin binding(GO:0005516)
0.2 0.5 GO:0000403 Y-form DNA binding(GO:0000403)
0.2 1.0 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2 0.7 GO:0000339 RNA cap binding(GO:0000339)
0.2 2.8 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.2 0.9 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 2.0 GO:0019904 protein domain specific binding(GO:0019904)
0.2 0.7 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 6.2 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.2 1.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 4.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 2.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 1.4 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 5.4 GO:0043130 ubiquitin binding(GO:0043130)
0.2 0.6 GO:0008144 drug binding(GO:0008144)
0.2 3.8 GO:0008047 enzyme activator activity(GO:0008047)
0.2 1.1 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.2 5.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 7.7 GO:0016791 phosphatase activity(GO:0016791)
0.2 6.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 3.0 GO:0042393 histone binding(GO:0042393)
0.2 2.7 GO:0015616 DNA translocase activity(GO:0015616)
0.2 0.5 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 1.0 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 1.3 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.2 0.8 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.2 3.1 GO:0051287 NAD binding(GO:0051287)
0.2 0.6 GO:0008106 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.2 2.2 GO:0016866 intramolecular transferase activity(GO:0016866)
0.2 0.3 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.2 3.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.9 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 5.8 GO:0016410 N-acyltransferase activity(GO:0016410)
0.1 0.5 GO:0032403 protein complex binding(GO:0032403)
0.1 1.1 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 1.0 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.1 3.9 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.3 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.1 1.9 GO:0030515 snoRNA binding(GO:0030515)
0.1 0.2 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.1 0.5 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 1.1 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.4 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 0.7 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.1 1.0 GO:0046983 protein dimerization activity(GO:0046983)
0.1 2.1 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 4.6 GO:0008168 methyltransferase activity(GO:0008168)
0.1 0.8 GO:0032947 protein complex scaffold(GO:0032947)
0.1 1.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 0.9 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.3 GO:0016798 hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.1 0.4 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 0.2 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.1 1.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.4 GO:0017069 snRNA binding(GO:0017069)
0.1 1.0 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.1 0.4 GO:0003777 microtubule motor activity(GO:0003777)
0.1 2.9 GO:0008289 lipid binding(GO:0008289)
0.1 0.8 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 0.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 3.1 GO:0003682 chromatin binding(GO:0003682)
0.0 0.3 GO:0016896 exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.3 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.2 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 1.4 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.3 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 3.6 GO:0003723 RNA binding(GO:0003723)
0.0 0.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.0 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.0 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.3 GO:0019899 enzyme binding(GO:0019899)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 6.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
1.3 5.4 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
1.2 6.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
1.2 3.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.1 3.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.0 3.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.7 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.6 3.1 PID PLK1 PATHWAY PLK1 signaling events
0.3 1.3 PID E2F PATHWAY E2F transcription factor network
0.3 0.8 PID MYC PATHWAY C-MYC pathway
0.1 0.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 0.3 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.0 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 24.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.8 5.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
1.5 24.4 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
1.5 6.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.0 4.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
1.0 3.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
1.0 3.9 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.8 5.9 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.8 4.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.6 2.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.6 3.4 REACTOME DNA STRAND ELONGATION Genes involved in DNA strand elongation
0.6 2.3 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.6 1.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.4 0.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.4 0.8 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 0.4 REACTOME HIV INFECTION Genes involved in HIV Infection
0.3 4.9 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.3 1.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.3 2.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.3 1.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 0.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 0.6 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.2 0.5 REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM Genes involved in Cytokine Signaling in Immune system
0.2 0.6 REACTOME CELL CYCLE MITOTIC Genes involved in Cell Cycle, Mitotic
0.2 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.1 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.1 0.6 REACTOME TRANSLATION Genes involved in Translation
0.1 1.2 REACTOME TRANSCRIPTION Genes involved in Transcription