Results for STE12
Z-value: 2.89
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Transcription factors associated with STE12
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
STE12
|
S000001126 | Transcription factor that is activated by a MAPK signaling cascade |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YCR018C Show fit | 29.01 |
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation |
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| YGR108W Show fit | 26.20 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YFR055W Show fit | 22.54 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 20.34 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YPR119W Show fit | 19.81 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YLR154C Show fit | 19.68 |
Ribonuclease H2 subunit, required for RNase H2 activity |
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| YIL052C Show fit | 19.39 |
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein |
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| YGL097W Show fit | 18.41 |
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p |
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| YLL045C Show fit | 18.30 |
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits |
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| YDR044W Show fit | 17.56 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
Network of associatons between targets according to the STRING database.
First level regulatory network of STE12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 254.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 3.5 | 63.7 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 6.9 | 48.1 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.4 | 46.1 | GO:0006364 | rRNA processing(GO:0006364) |
| 5.2 | 36.5 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 5.3 | 31.5 | GO:0009371 | positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371) |
| 1.9 | 26.2 | GO:0010383 | cell wall polysaccharide metabolic process(GO:0010383) |
| 3.2 | 22.2 | GO:0046501 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 7.3 | 21.9 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 2.0 | 21.6 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 183.5 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.1 | 128.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.5 | 63.2 | GO:0005933 | cellular bud(GO:0005933) |
| 0.3 | 53.6 | GO:0005829 | cytosol(GO:0005829) |
| 11.2 | 33.6 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 3.7 | 29.3 | GO:0042597 | periplasmic space(GO:0042597) |
| 0.5 | 28.9 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.2 | 28.8 | GO:0005730 | nucleolus(GO:0005730) |
| 0.5 | 26.3 | GO:0000131 | incipient cellular bud site(GO:0000131) |
| 0.1 | 25.3 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 304.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.9 | 43.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 8.8 | 35.1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.9 | 28.8 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.5 | 22.1 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 3.6 | 21.4 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 3.9 | 19.5 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.3 | 19.4 | GO:0003924 | GTPase activity(GO:0003924) |
| 4.8 | 19.2 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.6 | 17.0 | GO:0015631 | tubulin binding(GO:0015631) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 6.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 1.2 | 6.1 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 1.3 | 5.4 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 1.2 | 3.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.1 | 3.3 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 1.0 | 3.1 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.6 | 3.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 1.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.3 | 0.8 | PID MYC PATHWAY | C-MYC pathway |
| 0.7 | 0.7 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 24.4 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 3.0 | 24.2 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.5 | 6.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.8 | 5.9 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 1.8 | 5.3 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 4.9 | REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | Genes involved in Metabolism of lipids and lipoproteins |
| 0.8 | 4.1 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 1.0 | 4.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 1.0 | 3.9 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.6 | 3.4 | REACTOME DNA STRAND ELONGATION | Genes involved in DNA strand elongation |