Results for SKO1
Z-value: 0.75
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Transcription factors associated with SKO1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SKO1
|
S000005111 | Basic leucine zipper transcription factor of the ATF/CREB family |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR056C Show fit | 6.76 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YFR055W Show fit | 6.52 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YNL178W Show fit | 4.40 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
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| YFL022C Show fit | 2.69 |
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar |
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| YDR044W Show fit | 2.58 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
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| YPR119W Show fit | 2.57 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YHR094C Show fit | 2.55 |
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting |
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| YML127W Show fit | 2.52 |
Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
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| YDL023C Show fit | 2.45 |
Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance |
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| YJR145C Show fit | 2.23 |
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of SKO1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.6 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.4 | 6.6 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 2.2 | 6.5 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.2 | 4.9 | GO:0009303 | rRNA transcription(GO:0009303) |
| 0.3 | 3.6 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.1 | 3.4 | GO:0002097 | tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098) |
| 0.8 | 3.1 | GO:0070417 | response to cold(GO:0009409) cellular response to cold(GO:0070417) |
| 0.4 | 3.1 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.4 | 3.1 | GO:0046501 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.9 | 2.7 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.3 | 15.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 5.5 | GO:0005730 | nucleolus(GO:0005730) |
| 0.4 | 4.6 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 3.5 | GO:0005816 | microtubule organizing center(GO:0005815) spindle pole body(GO:0005816) |
| 0.1 | 3.3 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.2 | 3.0 | GO:0016586 | RSC complex(GO:0016586) |
| 0.1 | 2.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 2.6 | GO:0044445 | cytosolic part(GO:0044445) |
| 0.2 | 2.5 | GO:0000788 | nuclear nucleosome(GO:0000788) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 6.3 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.7 | 4.4 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.1 | 4.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.1 | 3.3 | GO:0051540 | iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540) |
| 0.1 | 3.2 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.1 | 3.1 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 3.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 0.3 | 2.9 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.2 | 2.9 | GO:0015616 | DNA translocase activity(GO:0015616) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.7 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.3 | 0.8 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.3 | 0.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 0.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 0.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 0.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.1 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 4.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.9 | 2.8 | REACTOME SIGNALLING TO ERKS | Genes involved in Signalling to ERKs |
| 0.5 | 2.0 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.2 | 1.4 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 0.3 | 0.8 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.0 | 0.8 | REACTOME M G1 TRANSITION | Genes involved in M/G1 Transition |
| 0.2 | 0.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 0.6 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 0.2 | 0.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |