Results for SFL1
Z-value: 1.23
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Transcription factors associated with SFL1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
SFL1
|
S000005666 | Transcriptional repressor and activator |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YAR053W Show fit | 19.66 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YAL062W Show fit | 15.53 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YAR060C Show fit | 13.64 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YHR212W-A Show fit | 10.91 |
Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
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| YHR212C Show fit | 10.78 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
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| YKR097W Show fit | 8.80 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YFR053C Show fit | 8.78 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YFL051C Show fit | 8.12 |
Putative protein of unknown function; YFL051C is not an essential gene |
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| YLR307C-A Show fit | 8.03 |
Putative protein of unknown function |
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| YCL001W-B Show fit | 7.76 |
Putative protein of unknown function; identified by homology |
Network of associatons between targets according to the STRING database.
First level regulatory network of SFL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 17.4 | GO:0000501 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 5.0 | 15.1 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 1.7 | 15.1 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.6 | 10.0 | GO:0042724 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 1.0 | 9.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 2.8 | 8.5 | GO:0015888 | thiamine transport(GO:0015888) |
| 0.4 | 7.9 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 0.1 | 7.5 | GO:0048468 | ascospore formation(GO:0030437) cell development(GO:0048468) |
| 2.4 | 7.2 | GO:0015755 | fructose transport(GO:0015755) |
| 1.7 | 7.0 | GO:0006848 | pyruvate transport(GO:0006848) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 34.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.3 | 13.2 | GO:0005770 | late endosome(GO:0005770) |
| 0.6 | 12.1 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.8 | 10.9 | GO:0005619 | ascospore wall(GO:0005619) |
| 0.2 | 10.6 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 9.9 | GO:0005774 | vacuolar membrane(GO:0005774) |
| 0.8 | 9.4 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.2 | 8.7 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 5.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 4.9 | GO:0033698 | Rpd3L complex(GO:0033698) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 16.2 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 3.2 | 16.1 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 3.9 | 15.6 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 3.8 | 15.3 | GO:0005537 | mannose binding(GO:0005537) |
| 0.5 | 9.9 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 1.1 | 8.6 | GO:0015205 | nucleobase transmembrane transporter activity(GO:0015205) |
| 0.8 | 8.6 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 1.1 | 7.4 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 1.8 | 7.2 | GO:0004396 | hexokinase activity(GO:0004396) |
| 0.3 | 7.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 175.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.9 | 8.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.2 | 3.6 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.4 | 1.6 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.6 | 1.1 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.4 | 0.8 | PID ANGIOPOIETIN RECEPTOR PATHWAY | Angiopoietin receptor Tie2-mediated signaling |
| 0.4 | 0.8 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.2 | 0.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 0.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 174.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.9 | 7.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 1.7 | 5.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.6 | 4.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.2 | 2.3 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.3 | 1.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 0.8 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.1 | 0.6 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.0 | 0.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.3 | 0.5 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |