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Results for RPH1

Z-value: 3.74

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Transcription factors associated with RPH1

Gene Symbol Gene ID Gene Info
RPH1
S000000971 JmjC domain-containing histone demethylase

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RPH1YER169W0.714.1e-05Click!

Activity profile of RPH1 motif

Sorted Z-values of RPH1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YMR107W 57.85
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YHR096C 54.27
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YBR072W 53.23
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YMR175W 48.90
SIP18
Protein of unknown function whose expression is induced by osmotic stress
YGR087C 47.02
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YNR034W-A 41.20 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YKL065W-A 40.50 Putative protein of unknown function
YGR256W 34.05
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YFR017C 33.78 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YHR139C 32.91
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YOL052C-A 32.54
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YKL217W 31.95
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR393W 31.87
ERR1
Protein of unknown function, has similarity to enolases
YAL062W 30.97
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAL054C 30.54
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YDR277C 29.30
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YNL117W 28.74
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YPL223C 27.88
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YIL136W 27.13
OM45
Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane
YGR088W 26.11
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YFR053C 24.11
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YPL036W 23.72
PMA2
Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential
YPL054W 22.97
LEE1
Zinc-finger protein of unknown function
YKL107W 22.47 Putative protein of unknown function
YPR010C-A 21.99 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YFL011W 21.80
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YLR312C 21.79
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YBR241C 21.40 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YMR081C 21.40
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YGR043C 21.26
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YOR391C 21.03
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YIL099W 20.16
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YDR070C 20.05
FMP16
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL049W 19.89
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YMR174C 19.80
PAI3
Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
YMR105C 19.53
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YOR186W 18.67 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YDL085W 18.38
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YPR030W 18.35
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YKL103C 18.31
LAP4
Vacuolar aminopeptidase, often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway
YER067W 17.81 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YKL163W 17.79
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YBL075C 17.35
SSA3
ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm
YKL148C 17.19
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YAL034C 17.16
FUN19
Non-essential protein of unknown function
YEL039C 17.01
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YDL222C 16.65
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YHL040C 16.58
ARN1
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores
YNR001C 16.55
CIT1
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein
YBR117C 16.55
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YKL102C 16.17 Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YOR031W 16.15
CRS5
Copper-binding metallothionein, required for wild-type copper resistance
YDL204W 16.07
RTN2
Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily
YDL130W-A 15.95
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YDR343C 15.68
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YIL101C 15.58
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YFL058W 15.55
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YJL116C 15.41
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YAR053W 15.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDL210W 15.27
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YGR067C 15.23 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YLR327C 14.60
TMA10
Protein of unknown function that associates with ribosomes
YER103W 14.54
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YGR243W 14.27
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR250W 13.94
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YBR214W 13.82
SDS24
One of two S. cerevisiae homologs (Sds23p and Sds24p) of the Schizosaccharomyces pombe Sds23 protein, which genetic studies have implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis
YNL014W 13.80
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YHR033W 13.64 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YLR377C 13.58
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YML089C 13.54 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YLR356W 13.45 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YOR348C 13.33
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YGR201C 13.31 Putative protein of unknown function
YPL240C 13.23
HSP82
Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
YDL218W 12.90 Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions
YOR374W 12.85
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YMR251W 12.55
GTO3
Omega class glutathione transferase; putative cytosolic localization
YDR258C 12.50
HSP78
Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded matrix proteins; component of the mitochondrial proteolysis system
YML131W 12.07 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YNL194C 11.86 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YEL070W 11.85
DSF1
Deletion suppressor of mpt5 mutation
YOR346W 11.72
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YGR144W 11.52
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YOR392W 11.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YPL222W 11.29
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOR100C 11.21
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YAR060C 11.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR127W 10.99 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YOR345C 10.87 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YMR206W 10.87 Putative protein of unknown function; YMR206W is not an essential gene
YIL107C 10.85
PFK26
6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, has negligible fructose-2,6-bisphosphatase activity, transcriptional regulation involves protein kinase A
YLR149C 10.81 Putative protein of unknown function; YLR149C is not an essential gene
YIL086C 10.73 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR192W 10.67
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YKL050C 10.43 Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
YDL214C 10.35
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YPL186C 10.25
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YMR181C 10.24 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YJR154W 10.23 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YER096W 10.08
SHC1
Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH
YDR342C 10.03
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YEL009C-A 9.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL156W 9.97
AMS1
Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YOR173W 9.94
DCS2
Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.
YNL332W 9.88
THI12
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YOL118C 9.78 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YAL061W 9.73
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YPR184W 9.61
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YAL005C 9.56
SSA1
ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall
YLR164W 9.55 Mitochondrial inner membrane of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YNL115C 9.47 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
YJR115W 9.45 Putative protein of unknown function
YGL096W 9.44
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YIL055C 9.39 Putative protein of unknown function
YJL089W 9.37
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YIR039C 9.35
YPS6
Putative GPI-anchored aspartic protease
YHR139C-A 9.34 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAL063C 9.31
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YKL066W 9.31 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
YMR196W 9.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene
YDR533C 8.97
HSP31
Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site
YLR326W 8.96 Hypothetical protein
YOL083W 8.96 Hypothetical protein
YPL185W 8.94 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YMR194C-B 8.84 Putative protein of unknown function
YNL092W 8.84 Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene
YMR169C 8.81
ALD3
Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YBR201C-A 8.75 Putative protein of unknown function
YLL041C 8.74
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YMR053C 8.59
STB2
Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p
YIL100C-A 8.59 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR267W 8.57
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YNL180C 8.53
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YDL181W 8.50
INH1
Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro
YML120C 8.49
NDI1
NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID
YHR087W 8.47
RTC3
Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity
YPL271W 8.46
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YML118W 8.45
NGL3
Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p
YHR212C 8.41 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR054W 8.36
YRO2
Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p
YEL011W 8.34
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YBR280C 8.27
SAF1
F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1
YDR505C 8.27
PSP1
Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition
YLR080W 8.27
EMP46
Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport
YPL119C 8.26
DBP1
Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs
YML090W 8.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YIL087C 8.16
LRC2
Putative protein of unknown function; protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YJR150C 8.10
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YFL019C 7.95 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YBR203W 7.94
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL077W 7.88
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNL179C 7.84 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YBR132C 7.83
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YKL031W 7.80 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YPR117W 7.78 Putative protein of unknown function
YIL100W 7.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A
YPL230W 7.71
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YHL021C 7.67
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YER065C 7.63
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YJL144W 7.61 Cytoplasmic hydrophilin of unknown function, possibly involved in the dessication response; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS
YPR027C 7.61 Putative protein of unknown function
YKR033C 7.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YHR212W-A 7.59 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YKL109W 7.53
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YAL028W 7.51
FRT2
Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YAL067C 7.44
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YMR103C 7.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR077C 7.37
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YEL010W 7.31 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR118C 7.25 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YPL282C 7.09
PAU22
Hypothetical protein
YPL017C 7.05
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YDR043C 7.02
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YJL020C 7.02
BBC1
Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches
YMR256C 7.01
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YJR149W 6.97 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YJL103C 6.97
GSM1
Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YAR050W 6.97
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YLR337C 6.96
VRP1
Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
YKL146W 6.95
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YOL047C 6.95 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YPR160W 6.94
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YCR010C 6.91
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YMR170C 6.87
ALD2
Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
YHR138C 6.83 Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles
YCR025C 6.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene
YKL147C 6.73 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YJL161W 6.73
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR248W 6.70
SOL4
6-phosphogluconolactonase with similarity to Sol3p
YAL039C 6.68
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YOR065W 6.67
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YDR322C-A 6.64
TIM11
Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
YEL030C-A 6.62 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YML091C 6.60
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YLR136C 6.58
TIS11
mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis
YDR446W 6.56
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YMR084W 6.55 Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains
YEL008W 6.52 Hypothetical protein predicted to be involved in metabolism
YPR061C 6.52
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YPR002W 6.50
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate

Network of associatons between targets according to the STRING database.

First level regulatory network of RPH1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.6 50.4 GO:0006848 pyruvate transport(GO:0006848)
12.1 48.6 GO:0009415 response to water(GO:0009415) cellular response to water stimulus(GO:0071462)
12.1 48.3 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
10.2 30.5 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
9.8 29.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
9.2 27.5 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
8.6 25.8 GO:0019676 ammonia assimilation cycle(GO:0019676)
8.3 91.1 GO:0015758 glucose transport(GO:0015758)
8.1 40.7 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
7.3 36.7 GO:0005980 glycogen catabolic process(GO:0005980)
7.0 21.1 GO:0006740 NADPH regeneration(GO:0006740)
6.6 19.9 GO:0006538 glutamate catabolic process(GO:0006538)
6.4 32.0 GO:0006083 acetate metabolic process(GO:0006083)
6.2 30.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
5.9 17.8 GO:0043335 protein unfolding(GO:0043335)
5.9 5.9 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
5.7 45.3 GO:0006097 glyoxylate cycle(GO:0006097)
5.0 10.0 GO:0006013 mannose metabolic process(GO:0006013)
4.9 9.7 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
4.6 41.5 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
4.0 16.1 GO:0015804 neutral amino acid transport(GO:0015804)
3.9 15.8 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
3.9 15.7 GO:0006598 polyamine catabolic process(GO:0006598)
3.9 23.2 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
3.8 11.4 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
3.5 35.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
3.1 31.4 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
3.1 12.4 GO:0015847 putrescine transport(GO:0015847)
3.1 15.3 GO:0043954 cellular component maintenance(GO:0043954)
3.0 8.9 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
2.9 26.2 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
2.8 8.5 GO:0043065 positive regulation of cell death(GO:0010942) positive regulation of apoptotic process(GO:0043065) positive regulation of programmed cell death(GO:0043068)
2.8 44.7 GO:0006754 ATP biosynthetic process(GO:0006754)
2.6 15.9 GO:0006537 glutamate biosynthetic process(GO:0006537)
2.6 10.3 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
2.5 40.7 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
2.5 12.4 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
2.5 12.4 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
2.3 7.0 GO:0071467 cellular response to pH(GO:0071467)
2.3 14.0 GO:0000920 cell separation after cytokinesis(GO:0000920)
2.2 6.7 GO:0018063 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
2.2 13.2 GO:0000492 box C/D snoRNP assembly(GO:0000492)
2.2 17.5 GO:0015891 siderophore transport(GO:0015891)
2.2 6.5 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
2.1 8.4 GO:0032102 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
2.0 26.6 GO:0008645 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
2.0 7.9 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
1.9 17.5 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
1.9 29.1 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.9 5.6 GO:0005993 trehalose catabolic process(GO:0005993)
1.8 5.3 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
1.7 7.0 GO:0019320 hexose catabolic process(GO:0019320)
1.7 8.7 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
1.7 13.5 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
1.7 3.3 GO:0072353 age-dependent response to reactive oxygen species(GO:0001315) cellular age-dependent response to reactive oxygen species(GO:0072353)
1.6 6.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
1.5 1.5 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.5 3.1 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
1.5 1.5 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
1.5 3.0 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
1.5 2.9 GO:0000304 response to singlet oxygen(GO:0000304)
1.5 7.3 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211)
1.5 2.9 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
1.4 15.9 GO:0015696 ammonium transport(GO:0015696)
1.4 4.3 GO:0006545 glycine biosynthetic process(GO:0006545)
1.4 12.8 GO:0070987 error-free translesion synthesis(GO:0070987)
1.4 5.6 GO:0046688 response to copper ion(GO:0046688)
1.4 5.4 GO:0031507 heterochromatin assembly(GO:0031507)
1.3 4.0 GO:0006108 malate metabolic process(GO:0006108)
1.3 7.9 GO:0051260 protein homooligomerization(GO:0051260)
1.3 5.3 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
1.3 2.5 GO:0000411 regulation of transcription by galactose(GO:0000409) positive regulation of transcription by galactose(GO:0000411)
1.2 8.7 GO:0010508 positive regulation of autophagy(GO:0010508)
1.2 7.4 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
1.2 27.1 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
1.2 10.5 GO:0006119 oxidative phosphorylation(GO:0006119)
1.1 3.4 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
1.1 1.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
1.1 2.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.1 21.7 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
1.1 2.2 GO:0071456 response to hypoxia(GO:0001666) cellular response to hypoxia(GO:0071456)
1.1 4.3 GO:0042732 D-xylose metabolic process(GO:0042732)
1.1 4.2 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
1.0 2.0 GO:0009313 oligosaccharide catabolic process(GO:0009313)
1.0 4.0 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
1.0 17.1 GO:0006749 glutathione metabolic process(GO:0006749)
1.0 7.9 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
1.0 4.9 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
1.0 2.9 GO:0015888 thiamine transport(GO:0015888)
1.0 40.2 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
1.0 2.9 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.9 2.8 GO:0044109 cellular alcohol catabolic process(GO:0044109)
0.9 3.7 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.9 4.6 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.9 2.8 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.9 1.8 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.9 0.9 GO:0006165 nucleoside diphosphate phosphorylation(GO:0006165)
0.9 6.2 GO:0015908 fatty acid transport(GO:0015908)
0.9 7.8 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.8 0.8 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.8 5.8 GO:0046686 response to cadmium ion(GO:0046686)
0.8 4.9 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.8 2.4 GO:0019748 secondary metabolic process(GO:0019748)
0.8 3.9 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.8 4.7 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.8 3.1 GO:0046058 cAMP metabolic process(GO:0046058)
0.8 3.1 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.8 9.0 GO:0016925 protein sumoylation(GO:0016925)
0.7 2.2 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.7 4.3 GO:0006452 translational frameshifting(GO:0006452)
0.7 0.7 GO:0046185 aldehyde catabolic process(GO:0046185)
0.7 4.8 GO:0000023 maltose metabolic process(GO:0000023)
0.7 2.7 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503)
0.7 3.3 GO:0008053 mitochondrial fusion(GO:0008053)
0.7 2.0 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.6 9.5 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.6 2.4 GO:0015793 glycerol transport(GO:0015793)
0.6 7.7 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.6 2.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.6 1.7 GO:2000911 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.6 6.2 GO:0042026 protein refolding(GO:0042026)
0.6 3.4 GO:0007532 regulation of mating-type specific transcription, DNA-templated(GO:0007532)
0.6 2.2 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.6 23.1 GO:0009060 aerobic respiration(GO:0009060)
0.5 0.5 GO:0045723 response to cold(GO:0009409) positive regulation of fatty acid biosynthetic process(GO:0045723) cellular response to cold(GO:0070417)
0.5 1.6 GO:0090630 activation of GTPase activity(GO:0090630)
0.5 1.6 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.5 2.0 GO:0034033 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.5 1.0 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.5 2.9 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.5 3.4 GO:0018345 protein palmitoylation(GO:0018345)
0.5 4.7 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.5 2.3 GO:0044070 regulation of anion transport(GO:0044070)
0.5 1.8 GO:0015846 polyamine transport(GO:0015846)
0.4 1.8 GO:0070933 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.4 8.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.4 0.9 GO:0043096 purine nucleobase salvage(GO:0043096)
0.4 4.6 GO:0010038 response to metal ion(GO:0010038)
0.4 1.3 GO:0032079 positive regulation of nuclease activity(GO:0032075) positive regulation of deoxyribonuclease activity(GO:0032077) positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.4 1.6 GO:0015809 arginine transport(GO:0015809)
0.4 3.1 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.4 1.1 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.4 15.6 GO:0048468 ascospore formation(GO:0030437) cell development(GO:0048468)
0.4 3.6 GO:0000767 cell morphogenesis involved in conjugation(GO:0000767)
0.4 1.4 GO:0046503 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464) glycerolipid catabolic process(GO:0046503)
0.3 1.7 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.3 1.7 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.3 6.5 GO:0031503 protein complex localization(GO:0031503)
0.3 1.7 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.3 1.0 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.3 0.3 GO:0015688 iron chelate transport(GO:0015688)
0.3 1.0 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.3 1.6 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.3 1.6 GO:0006265 DNA topological change(GO:0006265)
0.3 2.9 GO:0000011 vacuole inheritance(GO:0000011)
0.3 0.3 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.3 1.8 GO:0006279 premeiotic DNA replication(GO:0006279)
0.3 0.6 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.3 2.0 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.3 0.6 GO:0015883 FAD transport(GO:0015883)
0.3 0.9 GO:0042407 cristae formation(GO:0042407)
0.3 4.9 GO:0016579 protein deubiquitination(GO:0016579)
0.3 1.5 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.3 6.9 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.2 2.9 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.2 0.5 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.2 2.4 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 0.7 GO:0034762 regulation of transmembrane transport(GO:0034762) regulation of ion transport(GO:0043269)
0.2 2.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.2 1.1 GO:0000078 obsolete cytokinesis after mitosis checkpoint(GO:0000078)
0.2 1.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.2 1.0 GO:0000266 mitochondrial fission(GO:0000266)
0.2 1.0 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 2.5 GO:0009084 glutamine family amino acid biosynthetic process(GO:0009084)
0.2 0.7 GO:0002183 cytoplasmic translational initiation(GO:0002183)
0.2 2.5 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.2 0.7 GO:0032048 phosphatidylglycerol biosynthetic process(GO:0006655) cardiolipin metabolic process(GO:0032048)
0.2 1.9 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.2 0.2 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.2 0.7 GO:0030100 regulation of endocytosis(GO:0030100)
0.2 7.1 GO:0007031 peroxisome organization(GO:0007031)
0.2 1.0 GO:0006465 signal peptide processing(GO:0006465)
0.2 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.2 0.3 GO:0051984 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of proteolysis(GO:0045862) positive regulation of chromosome segregation(GO:0051984) positive regulation of proteasomal protein catabolic process(GO:1901800) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of proteolysis involved in cellular protein catabolic process(GO:1903052) positive regulation of cellular protein catabolic process(GO:1903364)
0.2 2.4 GO:0000902 cell morphogenesis(GO:0000902)
0.2 11.8 GO:0006457 protein folding(GO:0006457)
0.2 2.0 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.1 0.3 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.1 1.7 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 0.7 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.3 GO:0035690 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 0.5 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 1.4 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 0.8 GO:0000080 mitotic G1 phase(GO:0000080) G1 phase(GO:0051318)
0.1 1.0 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 1.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.3 GO:0051180 vitamin transport(GO:0051180)
0.1 0.5 GO:0048279 vesicle fusion with endoplasmic reticulum(GO:0048279)
0.1 0.4 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 0.3 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.1 2.2 GO:1902534 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.1 0.2 GO:0015867 ATP transport(GO:0015867)
0.1 0.5 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.1 0.5 GO:0016114 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.1 0.2 GO:0036010 protein localization to endosome(GO:0036010)
0.1 0.9 GO:0006611 protein export from nucleus(GO:0006611)
0.1 1.7 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.8 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.5 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.3 GO:0031930 mitochondria-nucleus signaling pathway(GO:0031930)
0.1 0.3 GO:0042537 benzene-containing compound metabolic process(GO:0042537)
0.1 0.5 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 1.1 GO:0022900 electron transport chain(GO:0022900)
0.1 0.2 GO:0019740 nitrogen utilization(GO:0019740)
0.1 0.3 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.1 1.1 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.2 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.0 0.6 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.1 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.2 GO:0015802 basic amino acid transport(GO:0015802)
0.0 0.1 GO:0045117 azole transport(GO:0045117)
0.0 0.2 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.9 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.0 1.1 GO:0048856 anatomical structure morphogenesis(GO:0009653) anatomical structure development(GO:0048856)
0.0 0.3 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.1 GO:0051181 cofactor transport(GO:0051181)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 32.7 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
6.2 30.9 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
3.7 7.3 GO:0032126 eisosome(GO:0032126)
3.3 9.9 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
2.9 35.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
2.8 36.8 GO:0005619 ascospore wall(GO:0005619)
2.4 21.8 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
2.2 27.0 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
2.2 15.7 GO:0034657 GID complex(GO:0034657)
2.1 8.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.9 33.8 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
1.8 14.3 GO:0042597 periplasmic space(GO:0042597)
1.8 5.3 GO:0001400 mating projection base(GO:0001400)
1.7 21.7 GO:0070469 respiratory chain(GO:0070469)
1.6 9.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.5 12.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.5 4.5 GO:0031166 integral component of vacuolar membrane(GO:0031166)
1.5 14.6 GO:0005775 vacuolar lumen(GO:0005775)
1.4 2.9 GO:0030061 mitochondrial crista(GO:0030061)
1.2 5.9 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
1.1 23.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
1.1 5.3 GO:0034448 EGO complex(GO:0034448)
1.0 3.1 GO:0045252 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
1.0 4.0 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.9 3.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.8 3.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.8 4.9 GO:0008180 COP9 signalosome(GO:0008180)
0.7 7.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.7 2.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 2.6 GO:0033551 monopolin complex(GO:0033551)
0.6 1.2 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.6 1.2 GO:0032389 MutLalpha complex(GO:0032389)
0.6 8.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.6 12.6 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.6 17.4 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.6 9.6 GO:0070822 Sin3-type complex(GO:0070822)
0.5 1.6 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.5 23.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.5 2.5 GO:0070772 PAS complex(GO:0070772)
0.5 9.7 GO:0098562 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.5 1.8 GO:0032116 SMC loading complex(GO:0032116)
0.5 64.2 GO:0000323 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.4 2.1 GO:0030478 actin cap(GO:0030478)
0.4 0.9 GO:0044284 mitochondrial crista junction(GO:0044284)
0.4 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.4 1.7 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.4 323.6 GO:0005739 mitochondrion(GO:0005739)
0.4 2.0 GO:0016459 myosin complex(GO:0016459)
0.4 6.8 GO:0005811 lipid particle(GO:0005811)
0.4 7.8 GO:0016592 mediator complex(GO:0016592)
0.3 5.8 GO:0031201 SNARE complex(GO:0031201)
0.3 1.9 GO:0031499 TRAMP complex(GO:0031499)
0.3 0.9 GO:0070274 RES complex(GO:0070274)
0.3 1.1 GO:0033101 cellular bud membrane(GO:0033101)
0.3 3.4 GO:0000812 Swr1 complex(GO:0000812)
0.3 1.3 GO:0005869 dynactin complex(GO:0005869)
0.3 2.8 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.2 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.2 1.3 GO:0031902 late endosome membrane(GO:0031902)
0.2 3.3 GO:0005802 trans-Golgi network(GO:0005802)
0.2 5.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.6 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.1 1.0 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 0.6 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.6 GO:0031011 Ino80 complex(GO:0031011)
0.1 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.3 GO:0097196 Shu complex(GO:0097196)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.5 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.9 GO:0042763 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.6 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.2 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614)
0.0 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.0 GO:0005822 inner plaque of spindle pole body(GO:0005822)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 48.3 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
10.9 32.7 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
10.8 32.3 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
10.2 30.5 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
9.9 49.4 GO:0015295 solute:proton symporter activity(GO:0015295)
9.0 27.1 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
6.5 25.8 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
6.3 25.2 GO:0004396 hexokinase activity(GO:0004396)
6.2 30.9 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
6.2 18.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
6.0 17.9 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
5.8 23.2 GO:0005537 mannose binding(GO:0005537)
5.3 32.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
5.2 20.7 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
5.1 25.7 GO:0050308 sugar-phosphatase activity(GO:0050308)
4.7 65.4 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
4.4 26.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
4.2 16.9 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
4.0 31.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
3.9 15.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
3.0 51.7 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
2.9 11.5 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
2.8 8.3 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.4 4.8 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
2.4 26.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
2.3 6.9 GO:0015188 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
2.3 16.1 GO:0004364 glutathione transferase activity(GO:0004364)
2.1 6.4 GO:0004629 phospholipase C activity(GO:0004629)
2.1 6.3 GO:0031072 heat shock protein binding(GO:0031072)
2.1 10.3 GO:0017022 myosin binding(GO:0017022)
2.0 10.0 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
1.9 9.7 GO:0008198 ferrous iron binding(GO:0008198)
1.9 11.7 GO:0090599 alpha-glucosidase activity(GO:0090599)
1.9 3.8 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
1.9 15.1 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
1.9 5.6 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
1.8 22.1 GO:0022838 substrate-specific channel activity(GO:0022838)
1.8 19.8 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
1.7 6.7 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
1.7 8.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
1.6 4.8 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
1.6 30.5 GO:0050661 NADP binding(GO:0050661)
1.6 121.4 GO:0051082 unfolded protein binding(GO:0051082)
1.4 4.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.4 7.0 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
1.4 17.7 GO:0044389 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
1.3 3.9 GO:0016872 intramolecular lyase activity(GO:0016872)
1.3 14.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
1.3 21.9 GO:0005507 copper ion binding(GO:0005507)
1.3 10.2 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
1.2 3.7 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
1.2 9.9 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
1.2 2.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
1.1 4.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.1 6.5 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
1.1 6.5 GO:0051213 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702) dioxygenase activity(GO:0051213)
1.1 2.1 GO:0017048 Rho GTPase binding(GO:0017048)
1.1 3.2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
1.0 26.6 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
1.0 15.3 GO:0016831 carboxy-lyase activity(GO:0016831)
1.0 6.1 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
1.0 3.0 GO:0070569 uridylyltransferase activity(GO:0070569)
1.0 6.9 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.9 6.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.9 13.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.8 2.5 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.8 21.0 GO:0004857 enzyme inhibitor activity(GO:0004857)
0.8 2.5 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.8 3.3 GO:0004180 carboxypeptidase activity(GO:0004180)
0.8 9.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.8 11.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.8 4.7 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.8 3.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.8 2.3 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.7 3.7 GO:0016830 carbon-carbon lyase activity(GO:0016830)
0.7 3.4 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.7 1.3 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.7 2.0 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.6 1.9 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.6 3.6 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 1.8 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.6 5.0 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.5 1.6 GO:0015294 solute:cation symporter activity(GO:0015294)
0.5 3.1 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.5 3.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.5 7.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 8.4 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.5 4.7 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 1.4 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.5 2.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.4 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 3.5 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.4 1.3 GO:0097027 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) ubiquitin-protein transferase activator activity(GO:0097027)
0.4 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.4 1.6 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.4 3.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.4 8.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.4 4.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4 1.5 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.4 2.9 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.4 2.9 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.4 1.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 0.7 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.3 1.0 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 1.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 1.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.3 12.3 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.3 1.5 GO:0004075 biotin carboxylase activity(GO:0004075)
0.3 2.9 GO:0043495 protein anchor(GO:0043495)
0.3 1.4 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.3 4.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.3 0.8 GO:0015293 symporter activity(GO:0015293)
0.3 1.6 GO:0004312 fatty acid synthase activity(GO:0004312)
0.3 1.1 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 3.4 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.3 2.3 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions(GO:0016722) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 9.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 3.3 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.2 2.4 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.2 19.1 GO:0005543 phospholipid binding(GO:0005543)
0.2 3.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 2.5 GO:0045182 translation regulator activity(GO:0045182)
0.2 1.0 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.2 0.8 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 1.0 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 1.0 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 15.2 GO:0019787 ubiquitin-like protein transferase activity(GO:0019787)
0.2 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.5 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 0.9 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 2.8 GO:0042802 identical protein binding(GO:0042802)
0.2 0.5 GO:0004457 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.2 0.6 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.1 0.7 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 4.6 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.1 1.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 1.0 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.1 0.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 1.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.3 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.1 1.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.1 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.1 1.4 GO:0015297 antiporter activity(GO:0015297)
0.1 1.7 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.4 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.3 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 1.4 GO:0005509 calcium ion binding(GO:0005509)
0.1 0.3 GO:0000772 mating pheromone activity(GO:0000772) receptor binding(GO:0005102) pheromone activity(GO:0005186)
0.1 0.9 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1 0.4 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.8 GO:0032947 protein complex scaffold(GO:0032947)
0.1 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 4.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.1 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 0.2 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.3 GO:0043022 ribosome binding(GO:0043022)
0.0 0.1 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.1 GO:0045118 azole transporter activity(GO:0045118)
0.0 0.2 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.1 GO:0042736 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.1 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.2 GO:0015036 disulfide oxidoreductase activity(GO:0015036)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.6 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
3.1 15.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
1.8 7.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.1 3.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.7 2.1 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.7 2.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.7 2.0 PID FOXO PATHWAY FoxO family signaling
0.3 0.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.3 453.8 PID BCR 5PATHWAY BCR signaling pathway
0.3 1.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 0.8 PID NOTCH PATHWAY Notch signaling pathway
0.2 0.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.1 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.7 26.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
3.0 33.5 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
1.3 2.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.9 2.7 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.9 3.4 REACTOME BIOLOGICAL OXIDATIONS Genes involved in Biological oxidations
0.5 1.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.5 1.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.4 1.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 5.5 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 453.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.2 0.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 1.4 REACTOME MEIOSIS Genes involved in Meiosis
0.1 1.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives