Results for ROX1
Z-value: 1.18
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Transcription factors associated with ROX1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ROX1
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S000006269 | Heme-dependent repressor of hypoxic genes |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 18.16 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 16.76 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YOL086C Show fit | 10.73 |
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway |
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| YCR018C Show fit | 7.54 |
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation |
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| YDR033W Show fit | 7.50 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YKR038C Show fit | 7.37 |
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex |
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| YNR001W-A Show fit | 7.32 |
Dubious open reading frame unlikely to encode a functional protein; identified by homology |
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| YHR181W Show fit | 6.73 |
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment |
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| YDR044W Show fit | 6.67 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
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| YGR108W Show fit | 6.34 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
Network of associatons between targets according to the STRING database.
First level regulatory network of ROX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 45.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 6.0 | 17.9 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.5 | 16.5 | GO:0016126 | steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126) |
| 0.1 | 14.5 | GO:0006364 | rRNA processing(GO:0006364) |
| 1.3 | 9.2 | GO:0046501 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 1.2 | 8.7 | GO:0019660 | glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707) |
| 0.6 | 8.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 2.6 | 7.7 | GO:0045901 | positive regulation of translational elongation(GO:0045901) |
| 0.9 | 7.7 | GO:0070525 | tRNA threonylcarbamoyladenosine metabolic process(GO:0070525) |
| 1.1 | 7.5 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 42.6 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.5 | 32.0 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 17.3 | GO:0005933 | cellular bud(GO:0005933) |
| 0.5 | 10.5 | GO:0031228 | integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228) |
| 0.5 | 8.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.2 | 8.7 | GO:0030686 | 90S preribosome(GO:0030686) |
| 1.5 | 7.5 | GO:0000408 | EKC/KEOPS complex(GO:0000408) |
| 1.1 | 7.5 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.2 | 6.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.4 | 6.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 55.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.6 | 15.5 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.6 | 14.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.3 | 12.3 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 2.0 | 12.1 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.7 | 10.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.2 | 8.8 | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616) |
| 0.8 | 7.6 | GO:0005216 | ion channel activity(GO:0005216) |
| 0.2 | 7.3 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 2.4 | 7.1 | GO:0004619 | phosphoglycerate mutase activity(GO:0004619) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.4 | 1.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.6 | 1.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.4 | 0.9 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.2 | 0.8 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 0.7 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.2 | 0.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 0.4 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.1 | 0.4 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.3 | 0.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 7.8 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 6.2 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.5 | 3.7 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.4 | 3.0 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.7 | 2.8 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.1 | 2.5 | REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS | Genes involved in Metabolism of lipids and lipoproteins |
| 0.9 | 1.8 | REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | Genes involved in The citric acid (TCA) cycle and respiratory electron transport |
| 0.2 | 1.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.5 | 1.5 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.4 | 1.4 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |