Results for PDR8
Z-value: 0.77
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Transcription factors associated with PDR8
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
PDR8
|
S000004256 | Transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YIL057C Show fit | 9.69 |
Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose |
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| YML042W Show fit | 8.13 |
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes |
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| YOR100C Show fit | 7.52 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YOR343C Show fit | 6.53 |
Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data |
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| YJL045W Show fit | 6.15 |
Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner |
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| YOR348C Show fit | 5.87 |
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
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| YJR095W Show fit | 5.27 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YMR107W Show fit | 4.92 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YAL062W Show fit | 4.70 |
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources |
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| YLR377C Show fit | 4.25 |
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism |
Network of associatons between targets according to the STRING database.
First level regulatory network of PDR8
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 10.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.7 | 10.0 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 3.0 | 8.9 | GO:0006577 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 0.5 | 7.7 | GO:0072593 | reactive oxygen species metabolic process(GO:0072593) |
| 1.6 | 6.3 | GO:0015804 | neutral amino acid transport(GO:0015804) |
| 0.5 | 6.2 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 0.2 | 5.5 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.3 | 5.2 | GO:0000436 | carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436) |
| 1.5 | 4.5 | GO:0019676 | ammonia assimilation cycle(GO:0019676) |
| 1.4 | 4.1 | GO:0015755 | fructose transport(GO:0015755) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.4 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 17.2 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 11.2 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.0 | 9.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.8 | 7.5 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.8 | 7.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.1 | 6.0 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 0.3 | 5.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.2 | 4.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.9 | 3.6 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 12.0 | GO:0015297 | antiporter activity(GO:0015297) |
| 0.9 | 10.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 3.0 | 8.9 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 1.4 | 6.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 1.6 | 6.5 | GO:0016639 | oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639) |
| 1.4 | 5.8 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 0.7 | 5.3 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.8 | 4.2 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 1.0 | 4.1 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.3 | 4.1 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 67.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.3 | 4.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 1.8 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.4 | 1.4 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.4 | 1.1 | PID FOXO PATHWAY | FoxO family signaling |
| 0.4 | 1.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 0.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 0.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 0.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 0.2 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 66.2 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.0 | 9.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.9 | 2.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.5 | 1.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.5 | 1.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 0.6 | REACTOME MEIOSIS | Genes involved in Meiosis |
| 0.1 | 0.4 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 0.2 | REACTOME INNATE IMMUNE SYSTEM | Genes involved in Innate Immune System |
| 0.1 | 0.2 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.0 | 0.2 | REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | Genes involved in Transmembrane transport of small molecules |