Results for ORC1
Z-value: 1.04
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Transcription factors associated with ORC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
ORC1
|
S000004530 | Largest subunit of the origin recognition complex |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YAR053W Show fit | 9.53 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YMR244W Show fit | 5.58 |
Putative protein of unknown function |
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| YAR060C Show fit | 5.39 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YLR311C Show fit | 5.28 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YHR212C Show fit | 4.66 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
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| YPR001W Show fit | 4.41 |
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate |
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| YHR212W-A Show fit | 4.14 |
Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching |
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| YER065C Show fit | 3.86 |
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose |
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| YBR200W-A Show fit | 3.86 |
Putative protein of unknown function; identified by fungal homology and RT-PCR |
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| YAL039C Show fit | 3.72 |
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) |
Network of associatons between targets according to the STRING database.
First level regulatory network of ORC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 9.2 | GO:0009228 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 0.4 | 7.4 | GO:0015749 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 1.2 | 7.0 | GO:0000501 | flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501) |
| 0.2 | 6.3 | GO:0010927 | cellular component assembly involved in morphogenesis(GO:0010927) |
| 1.9 | 5.8 | GO:0019626 | propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629) |
| 0.6 | 5.1 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.1 | 4.4 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.3 | 4.2 | GO:0000767 | cell morphogenesis involved in conjugation(GO:0000767) |
| 1.3 | 3.8 | GO:0018063 | protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063) |
| 0.1 | 3.8 | GO:0036003 | positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.0 | GO:0042763 | prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764) |
| 0.1 | 4.9 | GO:0044438 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.2 | 4.4 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.0 | 4.3 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.4 | 4.2 | GO:0031160 | spore wall(GO:0031160) |
| 0.1 | 4.1 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 3.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.2 | 3.3 | GO:0045259 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259) |
| 0.0 | 3.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.1 | 3.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.1 | GO:0005537 | mannose binding(GO:0005537) |
| 1.2 | 6.0 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.1 | 6.0 | GO:0004672 | protein kinase activity(GO:0004672) |
| 0.1 | 5.9 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.3 | 5.2 | GO:0019213 | deacetylase activity(GO:0019213) |
| 0.2 | 5.2 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 1.5 | 4.6 | GO:0004108 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.2 | 4.1 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 0.9 | 3.7 | GO:0001097 | TFIIH-class transcription factor binding(GO:0001097) |
| 0.2 | 3.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 106.8 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.7 | 2.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 0.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.2 | 0.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 0.4 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 0.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 0.2 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 0.2 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.2 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.0 | 0.1 | PID FOXO PATHWAY | FoxO family signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 105.8 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 2.8 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.8 | 2.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.8 | 2.3 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 1.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.3 | 0.8 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.3 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.2 | 0.2 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.1 | 0.2 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |