Results for OAF1
Z-value: 1.94
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Transcription factors associated with OAF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
OAF1
|
S000000048 | Oleate-activated transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YJR095W Show fit | 27.81 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YLR174W Show fit | 22.88 |
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose |
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| YJL045W Show fit | 21.55 |
Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner |
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| YNR002C Show fit | 19.96 |
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p |
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| YIL057C Show fit | 19.32 |
Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose |
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| YJR048W Show fit | 18.73 |
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration |
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| YLR377C Show fit | 18.54 |
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism |
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| YOR348C Show fit | 16.95 |
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells |
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| YJL116C Show fit | 16.58 |
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family |
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| YFR053C Show fit | 15.86 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
Network of associatons between targets according to the STRING database.
First level regulatory network of OAF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.2 | 61.7 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 3.0 | 30.0 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 2.6 | 28.5 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 9.3 | 27.8 | GO:0015740 | C4-dicarboxylate transport(GO:0015740) |
| 1.7 | 23.4 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 1.4 | 23.3 | GO:0072593 | reactive oxygen species metabolic process(GO:0072593) |
| 1.6 | 19.3 | GO:0019740 | nitrogen utilization(GO:0019740) |
| 4.8 | 19.2 | GO:0006848 | pyruvate transport(GO:0006848) |
| 6.4 | 19.1 | GO:0015755 | fructose transport(GO:0015755) |
| 6.1 | 18.4 | GO:0019626 | propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 88.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 1.1 | 63.1 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.4 | 56.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 3.1 | 37.5 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.5 | 34.0 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.6 | 26.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 26.0 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 2.0 | 15.8 | GO:0042597 | periplasmic space(GO:0042597) |
| 2.3 | 13.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 3.8 | 11.5 | GO:0031422 | RecQ helicase-Topo III complex(GO:0031422) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 28.4 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 8.2 | 24.7 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 4.6 | 22.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 2.1 | 22.7 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 6.7 | 20.0 | GO:0036440 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 4.8 | 19.3 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 5.9 | 17.6 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 1.8 | 17.6 | GO:0015205 | nucleobase transmembrane transporter activity(GO:0015205) |
| 3.4 | 16.8 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 2.1 | 16.6 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 247.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.3 | 11.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 2.3 | 7.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.7 | 5.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.1 | 3.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 2.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.4 | 1.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 1.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 0.5 | PID P73PATHWAY | p73 transcription factor network |
| 0.2 | 0.4 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 241.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 2.6 | 23.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 6.2 | 18.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 1.7 | 5.2 | REACTOME PI3K EVENTS IN ERBB2 SIGNALING | Genes involved in PI3K events in ERBB2 signaling |
| 1.7 | 5.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.2 | 1.2 | REACTOME HEMOSTASIS | Genes involved in Hemostasis |
| 0.3 | 1.1 | REACTOME BIOLOGICAL OXIDATIONS | Genes involved in Biological oxidations |
| 0.3 | 1.0 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 0.7 | REACTOME INNATE IMMUNE SYSTEM | Genes involved in Innate Immune System |
| 0.0 | 0.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |