Results for NRG1
Z-value: 1.26
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Transcription factors associated with NRG1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NRG1
|
S000002450 | Transcriptional repressor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YKL218C Show fit | 7.65 |
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate |
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| YBR158W Show fit | 7.21 |
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) |
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| YCR018C Show fit | 5.64 |
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation |
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| YDR044W Show fit | 5.19 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
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| YDR509W Show fit | 4.57 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
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| YDR508C Show fit | 4.51 |
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids |
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| YEL040W Show fit | 4.14 |
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance |
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| YDR133C Show fit | 4.00 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C |
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| YPL250W-A Show fit | 3.74 |
Identified by fungal homology and RT-PCR |
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| YOL154W Show fit | 3.65 |
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRG1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.2 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.1 | 10.4 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.9 | 9.0 | GO:0042219 | cellular modified amino acid catabolic process(GO:0042219) |
| 1.0 | 6.8 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501) |
| 0.3 | 5.1 | GO:0001100 | negative regulation of exit from mitosis(GO:0001100) |
| 0.5 | 5.0 | GO:0006797 | polyphosphate metabolic process(GO:0006797) |
| 0.1 | 4.5 | GO:0006694 | steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126) |
| 0.6 | 4.4 | GO:0071267 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267) |
| 0.3 | 4.4 | GO:0006037 | cell wall chitin metabolic process(GO:0006037) |
| 0.0 | 4.4 | GO:0032543 | mitochondrial translation(GO:0032543) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.9 | GO:0005576 | extracellular region(GO:0005576) |
| 0.1 | 11.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 7.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 5.6 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 4.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 4.9 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 0.5 | 4.5 | GO:0000144 | cellular bud neck septin ring(GO:0000144) |
| 0.1 | 4.2 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.1 | 3.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 3.6 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.1 | 8.3 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.2 | 6.8 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 0.5 | 5.7 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
| 1.1 | 4.4 | GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634) |
| 0.1 | 4.3 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.3 | 4.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.1 | 3.8 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.1 | 3.7 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.3 | 3.3 | GO:0005496 | steroid binding(GO:0005496) sterol binding(GO:0032934) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 1.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.4 | 1.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 0.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 0.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.3 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.4 | 1.3 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.2 | 1.1 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 0.8 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |
| 0.2 | 0.7 | REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| 0.1 | 0.6 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.1 | 0.6 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.2 | 0.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 0.4 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.1 | 0.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |