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Results for NRG1

Z-value: 1.26

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Transcription factors associated with NRG1

Gene Symbol Gene ID Gene Info
NRG1
S000002450 Transcriptional repressor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NRG1YDR043C-0.766.4e-06Click!

Activity profile of NRG1 motif

Sorted Z-values of NRG1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YKL218C 7.65
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YBR158W 7.21
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YCR018C 5.64
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YDR044W 5.19
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YDR509W 4.57 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR508C 4.51
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YEL040W 4.14
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YDR133C 4.00 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C
YPL250W-A 3.74 Identified by fungal homology and RT-PCR
YOL154W 3.65
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YOL015W 3.64
IRC10
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci
YDR041W 3.21
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YJR094W-A 3.21
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YLR110C 2.91
CCW12
Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor
YGR108W 2.87
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YOL016C 2.85
CMK2
Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II
YNL058C 2.75 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene
YOL155C 2.72
HPF1
Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines
YML123C 2.71
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YDR040C 2.70
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YKR013W 2.70
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YEL001C 2.55
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YGL179C 2.47
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YLR348C 2.43
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YLR349W 2.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YKR012C 2.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YIR021W 2.35
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YLR062C 2.33
BUD28
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YDR502C 2.31
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YDL241W 2.31 Putative protein of unknown function; YDL241W is not an essential gene
YPR157W 2.31 Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YML075C 2.27
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YHR136C 2.25
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YER146W 2.24
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YOL014W 2.23 Putative protein of unknown function
YLR013W 2.16
GAT3
Protein containing GATA family zinc finger motifs
YNL057W 2.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR031C 2.12
RRM3
DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p
YHR181W 2.11
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YHR162W 2.10 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
YBR066C 2.08
NRG2
Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YDR112W 2.07
IRC2
Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci
YOR226C 2.06
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable
YLR012C 2.06 Putative protein of unknown function; YLR012C is not an essential gene
YGL101W 2.04 Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
YLR432W 1.97
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YGR264C 1.97
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YHR180W-A 1.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YKR079C 1.87
TRZ1
tRNase Z, involved in RNA processing, has two putative nucleotide triphosphate-binding motifs (P-loop) and a conserved histidine motif, homolog of the human candidate prostate cancer susceptibility gene ELAC2
YGR265W 1.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YMR296C 1.85
LCB1
Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YIR013C 1.81
GAT4
Protein containing GATA family zinc finger motifs
YNL160W 1.80
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YGL012W 1.79
ERG4
C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol
YMR123W 1.78
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YER001W 1.77
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YGR124W 1.76
ASN2
Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway
YER073W 1.76
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YOR029W 1.72 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR154C 1.70
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YDL075W 1.70
RPL31A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YER011W 1.69
TIR1
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking
YIL169C 1.69 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YGL102C 1.68 Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein
YDL055C 1.67
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YPL273W 1.66
SAM4
S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YDR111C 1.66
ALT2
Putative alanine transaminase (glutamic pyruvic transaminase)
YKL096W-A 1.65
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YBR164C 1.63
ARL1
Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor
YKL120W 1.63
OAC1
Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, and thiosulfate; member of the mitochondrial carrier family
YKL091C 1.62 Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus
YPL003W 1.61
ULA1
Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation
YAL059W 1.61
ECM1
Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export
YOR108W 1.60
LEU9
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant
YEL020C-B 1.58 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR
YJR063W 1.57
RPA12
RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex
YHR032W 1.57 Putative protein of unknown function; putative substrate of the cAMP-dependent protein kinase (PKA)
YLR286C 1.57
CTS1
Endochitinase, required for cell separation after mitosis; transcriptional activation during late G and early M cell cycle phases is mediated by transcription factor Ace2p
YMR246W 1.55
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YBR067C 1.52
TIP1
Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
YBR069C 1.52
TAT1
Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YDR095C 1.52 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR154W-B 1.51 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YHR045W 1.51 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YNL113W 1.51
RPC19
RNA polymerase subunit, common to RNA polymerases I and III
YDR535C 1.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.
YOR176W 1.44
HEM15
Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YLR249W 1.44
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YNL234W 1.42 Similar to globins and has a functional heme-binding domain; involved in glucose signaling or metabolism; regulated by Rgt1p
YDR534C 1.41
FIT1
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YGR131W 1.40 Protein of unknown function; expression induced in response to ketoconazole; promoter region contains a sterol regulatory element motif, which has been identified as a Upc2p-binding site
YER048W-A 1.39
ISD11
Protein required for mitochondrial iron-sulfur cluster biosynthesis
YBR177C 1.38
EHT1
Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane
YLR312W-A 1.37
MRPL15
Mitochondrial ribosomal protein of the large subunit
YLR089C 1.37
ALT1
Putative alanine transaminase (glutamic pyruvic transaminase); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YKL014C 1.36
URB1
Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit
YHL003C 1.35
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YMR194C-A 1.33 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR297W 1.33
PRC1
Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YLR154W-A 1.31 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGR266W 1.31 Protein of unknown function, predicted to contain a single transmembrane domain; localized to both the mitochondrial outer membrane and the plasma membrane
YMR009W 1.30
ADI1
Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions
YDR471W 1.28
RPL27B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YBL044W 1.28 Putative protein of unknown function; YBL044W is not an essential protein
YGL028C 1.28
SCW11
Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p
YMR183C 1.27
SSO2
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YPL004C 1.26
LSP1
Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways
YDR517W 1.26
GRH1
Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes
YPR063C 1.25 ER-localized protein of unknown function
YGR195W 1.25
SKI6
3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YNL028W 1.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR020W 1.24 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
YNL043C 1.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YER028C 1.24
MIG3
Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes
YDR435C 1.22
PPM1
Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits
YPL265W 1.21
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YIL011W 1.20
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YAL029C 1.19
MYO4
One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p
YGR123C 1.19
PPT1
Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing
YMR319C 1.17
FET4
Low-affinity Fe(II) transporter of the plasma membrane
YCR022C 1.16 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene
YBR286W 1.16
APE3
Vacuolar aminopeptidase Y, processed to mature form by Prb1p
YKL090W 1.16
CUE2
Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination
YDR353W 1.15
TRR1
Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress
YEL038W 1.15
UTR4
Protein of unknown function with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, found in both the cytoplasm and nucleus
YJL196C 1.14
ELO1
Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YGR121W-A 1.13 Putative protein of unknown function
YMR209C 1.13 Putative protein of unknown function; YMR209C is not an essential gene
YOR175C 1.12
ALE1
Lysophospholipid acyltransferase, partially redundant with Slc1p; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids
YOR028C 1.11
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YOR153W 1.10
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YDL018C 1.10
ERP3
Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YMR083W 1.09
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YKL096W 1.09
CWP1
Cell wall mannoprotein, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; involved in cell wall organization
YDR094W 1.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
YFL015C 1.08 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YDL022C-A 1.07 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YJR006W 1.06
POL31
DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair
YHR144C 1.06
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YIL111W 1.05
COX5B
Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth
YFR055W 1.05
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR206W 1.04
ENT2
Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
YBR205W 1.03
KTR3
Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YFL015W-A 1.02 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER048C 1.02
CAJ1
Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly
YGL202W 1.01
ARO8
Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis
YOR012W 1.01 Putative protein of unknown function
YHR137W 1.01
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YOR050C 1.01 Hypothetical protein
YOR163W 1.00
DDP1
Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases
YMR251W-A 1.00
HOR7
Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor
YHR019C 1.00
DED81
Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YNL231C 1.00
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YNL029C 1.00
KTR5
Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family
YDL242W 0.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR344C 0.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR320W 0.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR208W 0.98
BAT1
Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YGL258W 0.96
VEL1
Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants
YDR074W 0.96
TPS2
Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway
YMR008C 0.95
PLB1
Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YNL056W 0.95
OCA2
Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
YKR092C 0.94
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YPR062W 0.93
FCY1
Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
YMR102C 0.93 Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene
YBL085W 0.93
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YCR006C 0.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR146C 0.91 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR107W 0.91 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL130W 0.90
ALR1
Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YLR011W 0.89
LOT6
FMN-dependent NAD(P)H:quinone reductase that may be involved in quinone detoxification; gene expression increases in cultures shifted to a lower temperature
YGR138C 0.88
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YDR491C 0.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL263C 0.87
KEL3
Cytoplasmic protein of unknown function
YBR249C 0.87
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YFR056C 0.87 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YMR241W 0.86
YHM2
Mitochondrial DNA-binding protein, component of the mitochondrial nucleoid structure, involved in mtDNA replication and segregation of mitochondrial genomes; member of the mitochondrial carrier protein family
YIL133C 0.85
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YGR106C 0.85
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YNL168C 0.85
FMP41
Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPL075W 0.85
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YDR492W 0.84
IZH1
Membrane protein involved in zinc metabolism, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
YDR098C 0.84
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YPR012W 0.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene
YDL090C 0.83
RAM1
Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit
YPL177C 0.83
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YDL134C 0.83
PPH21
Catalytic subunit of protein phosphatase 2A, functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis
YBR053C 0.82 Putative protein of unknown function; induced by cell wall perturbation
YBR238C 0.82 Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span
YLR350W 0.82
ORM2
Evolutionarily conserved protein with similarity to Orm1p, required for resistance to agents that induce the unfolded protein response; human ortholog is located in the endoplasmic reticulum
YOR008C-A 0.82 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YDR185C 0.81 Mitochondrial protein of unknown function; has similarity to Ups1p, which is involved in regulation of alternative topogenesis of the dynamin-related GTPase Mgm1p
YNR021W 0.81 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene
YDR516C 0.81
EMI2
Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YNL010W 0.80 Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
YLR063W 0.80 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
YMR082C 0.79 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL021W-A 0.79 Putative protein of unknown function
YDR129C 0.79
SAC6
Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton
YJR065C 0.79
ARP3
Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity

Network of associatons between targets according to the STRING database.

First level regulatory network of NRG1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
1.0 6.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.9 9.0 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.7 2.6 GO:0098609 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.6 4.4 GO:0071267 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.6 1.9 GO:0046039 GTP biosynthetic process(GO:0006183) GTP metabolic process(GO:0046039)
0.6 2.4 GO:0000296 spermine transport(GO:0000296)
0.6 2.3 GO:0019287 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
0.6 2.3 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.6 1.7 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.6 3.3 GO:0006491 N-glycan processing(GO:0006491)
0.5 1.6 GO:0008272 sulfate transport(GO:0008272)
0.5 1.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.5 3.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.5 2.1 GO:0015909 long-chain fatty acid transport(GO:0015909) fatty-acyl-CoA metabolic process(GO:0035337)
0.5 1.5 GO:0042992 negative regulation of transcription factor import into nucleus(GO:0042992)
0.5 5.0 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.5 0.5 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.4 1.8 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.4 1.2 GO:0019413 acetate biosynthetic process(GO:0019413)
0.4 2.9 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.4 1.1 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.4 1.5 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.4 1.9 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.4 1.4 GO:0010138 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) pyrimidine nucleoside salvage(GO:0043097) UMP salvage(GO:0044206)
0.3 2.4 GO:0006814 sodium ion transport(GO:0006814)
0.3 5.1 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.3 1.3 GO:0019748 secondary metabolic process(GO:0019748)
0.3 1.0 GO:0006567 threonine catabolic process(GO:0006567)
0.3 1.6 GO:0009098 leucine biosynthetic process(GO:0009098)
0.3 4.4 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.3 1.6 GO:0006026 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.3 1.2 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.3 1.2 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.3 0.6 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
0.3 2.4 GO:0000376 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.3 1.2 GO:0015680 intracellular copper ion transport(GO:0015680)
0.3 1.1 GO:0030497 fatty acid elongation(GO:0030497)
0.3 0.8 GO:0072363 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
0.3 0.8 GO:2000877 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.3 0.8 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.3 1.6 GO:0045116 protein neddylation(GO:0045116)
0.2 0.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
0.2 0.5 GO:0035969 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.2 0.2 GO:0032973 amino acid export(GO:0032973)
0.2 0.7 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.2 1.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.2 1.4 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.2 1.2 GO:1990748 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.2 0.7 GO:0015693 magnesium ion transport(GO:0015693)
0.2 2.1 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.2 0.5 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187) adenylate cyclase-modulating G-protein coupled receptor signaling pathway(GO:0007188)
0.2 0.7 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.2 1.3 GO:0046513 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.2 1.3 GO:0007030 Golgi organization(GO:0007030)
0.2 0.7 GO:0015691 cadmium ion transport(GO:0015691)
0.2 3.7 GO:0007009 plasma membrane organization(GO:0007009)
0.2 4.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 0.4 GO:0015848 spermidine transport(GO:0015848)
0.2 0.6 GO:0045862 positive regulation of proteolysis(GO:0045862)
0.2 0.6 GO:0015908 fatty acid transport(GO:0015908)
0.2 1.2 GO:0048309 endoplasmic reticulum inheritance(GO:0048309)
0.2 0.7 GO:0007050 cell cycle arrest(GO:0007050)
0.2 1.0 GO:0006783 porphyrin-containing compound biosynthetic process(GO:0006779) heme biosynthetic process(GO:0006783) tetrapyrrole biosynthetic process(GO:0033014)
0.2 0.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.2 1.8 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.2 1.0 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.2 3.2 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.2 0.6 GO:0046037 GMP metabolic process(GO:0046037)
0.2 0.8 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 0.3 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.2 1.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.2 1.2 GO:0043687 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.2 1.1 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.1 2.1 GO:0006415 translational termination(GO:0006415)
0.1 0.1 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.1 4.5 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 2.2 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 1.4 GO:0006116 NADH oxidation(GO:0006116)
0.1 0.4 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 1.4 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.1 1.0 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 1.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 4.3 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.4 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 1.2 GO:0007120 axial cellular bud site selection(GO:0007120)
0.1 2.4 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.1 0.4 GO:0010039 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 0.3 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 3.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 0.1 GO:0006531 aspartate metabolic process(GO:0006531)
0.1 0.8 GO:0009636 response to toxic substance(GO:0009636)
0.1 0.6 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 0.5 GO:0090337 regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338)
0.1 2.3 GO:0006885 regulation of pH(GO:0006885)
0.1 0.9 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.3 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.7 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082)
0.1 1.4 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.1 0.3 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.1 0.3 GO:0000092 mitotic anaphase B(GO:0000092) plasmid partitioning(GO:0030541)
0.1 0.9 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.3 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 1.1 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.1 12.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 0.3 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.1 0.4 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.1 0.3 GO:0034476 U5 snRNA 3'-end processing(GO:0034476)
0.1 0.5 GO:0015677 copper ion import(GO:0015677)
0.1 0.7 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.4 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 0.3 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1 0.1 GO:0009394 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
0.1 0.2 GO:0046083 adenine metabolic process(GO:0046083)
0.1 0.5 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.1 1.3 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.1 0.8 GO:0071047 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.1 0.4 GO:0030847 termination of RNA polymerase II transcription, exosome-dependent(GO:0030847)
0.1 0.1 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.1 1.3 GO:0009062 fatty acid catabolic process(GO:0009062)
0.1 0.7 GO:0051666 actin cortical patch localization(GO:0051666)
0.1 0.7 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.1 0.4 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 0.6 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.1 0.6 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 1.5 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 10.4 GO:0006364 rRNA processing(GO:0006364)
0.1 0.2 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.1 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.1 1.3 GO:0090329 regulation of DNA-dependent DNA replication(GO:0090329)
0.1 0.2 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.2 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 0.6 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.4 GO:0016233 telomere capping(GO:0016233)
0.1 0.2 GO:0031134 sister chromatid biorientation(GO:0031134)
0.1 0.3 GO:0044070 regulation of anion transport(GO:0044070)
0.1 0.2 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.2 GO:0006835 dicarboxylic acid transport(GO:0006835)
0.0 1.3 GO:0046467 GPI anchor biosynthetic process(GO:0006506) glycolipid biosynthetic process(GO:0009247) membrane lipid biosynthetic process(GO:0046467)
0.0 4.4 GO:0032543 mitochondrial translation(GO:0032543)
0.0 1.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.3 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.1 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.0 0.3 GO:0016559 peroxisome fission(GO:0016559)
0.0 1.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.1 GO:0006083 acetate metabolic process(GO:0006083)
0.0 0.3 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 0.3 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.0 0.0 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.0 0.1 GO:0000916 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.0 0.2 GO:0019365 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.0 0.7 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094)
0.0 0.5 GO:0010833 telomere maintenance via telomerase(GO:0007004) telomere maintenance via telomere lengthening(GO:0010833)
0.0 0.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.4 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.0 0.1 GO:0015867 ATP transport(GO:0015867)
0.0 0.3 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 1.5 GO:0016050 vesicle organization(GO:0016050)
0.0 0.2 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.0 0.1 GO:0042182 ketone catabolic process(GO:0042182)
0.0 0.1 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.0 0.1 GO:0007535 donor selection(GO:0007535)
0.0 0.1 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.0 0.2 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.0 0.1 GO:0043433 regulation of establishment or maintenance of cell polarity(GO:0032878) negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 0.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.2 GO:0006113 fermentation(GO:0006113)
0.0 0.1 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.0 0.1 GO:0006273 lagging strand elongation(GO:0006273)
0.0 0.3 GO:0048311 mitochondrion inheritance(GO:0000001) mitochondrion distribution(GO:0048311)
0.0 0.1 GO:0000921 septin ring assembly(GO:0000921)
0.0 0.3 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.1 GO:0051325 interphase(GO:0051325) mitotic interphase(GO:0051329)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.9 GO:0008033 tRNA processing(GO:0008033)
0.0 0.3 GO:0006096 glycolytic process(GO:0006096) nucleoside diphosphate phosphorylation(GO:0006165) ATP generation from ADP(GO:0006757)
0.0 0.5 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.2 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0070085 glycosylation(GO:0070085)
0.0 0.0 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.1 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.1 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.0 GO:0032006 regulation of TOR signaling(GO:0032006)
0.0 0.4 GO:0032259 methylation(GO:0032259)
0.0 0.0 GO:0015883 FAD transport(GO:0015883)
0.0 0.0 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.8 2.3 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.5 4.5 GO:0000144 cellular bud neck septin ring(GO:0000144)
0.4 2.7 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.4 1.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.3 2.4 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.3 2.2 GO:0005688 U6 snRNP(GO:0005688)
0.2 0.7 GO:0000928 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.2 1.0 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.2 3.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 1.1 GO:0044426 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.2 0.8 GO:0032126 eisosome(GO:0032126)
0.2 0.8 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.2 0.6 GO:0044697 HICS complex(GO:0044697)
0.2 4.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 13.9 GO:0005576 extracellular region(GO:0005576)
0.2 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 1.1 GO:0030132 clathrin coat of coated pit(GO:0030132)
0.2 1.2 GO:0016459 myosin complex(GO:0016459)
0.2 1.9 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.2 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 0.5 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.2 0.5 GO:0070939 Dsl1p complex(GO:0070939)
0.2 1.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 0.8 GO:0030478 actin cap(GO:0030478)
0.2 2.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 3.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 2.1 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 1.9 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.1 4.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 11.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 0.8 GO:0032432 actin filament bundle(GO:0032432)
0.1 0.7 GO:0042597 periplasmic space(GO:0042597)
0.1 0.6 GO:0042555 MCM complex(GO:0042555)
0.1 3.8 GO:0005811 lipid particle(GO:0005811)
0.1 0.4 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.8 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.3 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.5 GO:0034044 exomer complex(GO:0034044)
0.1 0.4 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
0.1 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.3 GO:0046930 pore complex(GO:0046930)
0.1 0.7 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 1.0 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.1 0.7 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.6 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 1.4 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1 0.5 GO:0034456 UTP-C complex(GO:0034456)
0.1 0.5 GO:0000346 transcription export complex(GO:0000346)
0.1 3.1 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 0.3 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.8 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 0.2 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.1 0.2 GO:0030133 transport vesicle(GO:0030133)
0.1 4.9 GO:0022626 cytosolic ribosome(GO:0022626)
0.1 0.6 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.1 1.2 GO:0009277 fungal-type cell wall(GO:0009277)
0.1 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.6 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 0.4 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.4 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.3 GO:0005940 septin ring(GO:0005940)
0.0 0.3 GO:0005871 kinesin complex(GO:0005871)
0.0 2.5 GO:0005840 ribosome(GO:0005840)
0.0 7.5 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.2 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.1 GO:0034099 luminal surveillance complex(GO:0034099)
0.0 0.2 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0070545 PeBoW complex(GO:0070545)
0.0 0.1 GO:0000938 GARP complex(GO:0000938)
0.0 5.6 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.1 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.0 0.2 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.0 GO:0030665 clathrin vesicle coat(GO:0030125) clathrin-coated vesicle membrane(GO:0030665)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.3 GO:0016586 RSC complex(GO:0016586)
0.0 0.1 GO:0031518 CBF3 complex(GO:0031518)
0.0 3.1 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0033101 cellular bud membrane(GO:0033101)
0.0 0.2 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.0 2.7 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.1 GO:0034448 EGO complex(GO:0034448)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0032045 eukaryotic translation initiation factor 2B complex(GO:0005851) guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.0 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.0 0.8 GO:0005635 nuclear envelope(GO:0005635)
0.0 1.8 GO:0005829 cytosol(GO:0005829)
0.0 0.0 GO:1902555 endoribonuclease complex(GO:1902555)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.3 GO:0016841 ammonia-lyase activity(GO:0016841)
1.1 4.4 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.7 2.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.6 2.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.6 2.4 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.6 2.4 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.6 2.3 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.6 2.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.6 2.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.6 1.7 GO:0070568 guanylyltransferase activity(GO:0070568)
0.5 1.6 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.5 2.5 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.5 5.7 GO:0005199 structural constituent of cell wall(GO:0005199)
0.5 2.3 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.5 1.4 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.4 2.6 GO:0016408 C-acyltransferase activity(GO:0016408)
0.4 2.1 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.4 1.2 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.4 1.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.4 1.9 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.3 1.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.3 4.1 GO:0005516 calmodulin binding(GO:0005516)
0.3 1.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 3.3 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.3 1.0 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.3 1.3 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.3 0.3 GO:0019003 GDP binding(GO:0019003)
0.3 1.2 GO:0070300 phosphatidic acid binding(GO:0070300)
0.3 1.8 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 1.2 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.3 1.4 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.3 1.1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.3 1.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 1.1 GO:0005034 osmosensor activity(GO:0005034)
0.3 1.0 GO:0004180 carboxypeptidase activity(GO:0004180)
0.3 0.8 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.2 2.5 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.2 2.4 GO:0019239 deaminase activity(GO:0019239)
0.2 0.5 GO:0003785 actin monomer binding(GO:0003785)
0.2 0.9 GO:0008198 ferrous iron binding(GO:0008198)
0.2 1.4 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.2 1.6 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.2 3.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 2.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 0.6 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.2 2.7 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.2 1.0 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.2 0.4 GO:0015606 spermidine transmembrane transporter activity(GO:0015606)
0.2 0.8 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 0.8 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2 6.8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 2.9 GO:0050661 NADP binding(GO:0050661)
0.2 0.2 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.2 0.7 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.2 0.7 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 1.5 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.2 1.8 GO:0004177 aminopeptidase activity(GO:0004177)
0.2 0.8 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.2 0.9 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 0.6 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.7 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.7 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.1 2.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 2.9 GO:0008237 metallopeptidase activity(GO:0008237)
0.1 0.6 GO:0004396 hexokinase activity(GO:0004396)
0.1 0.8 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 1.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.9 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 4.3 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.5 GO:0019206 nucleoside kinase activity(GO:0019206)
0.1 3.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 0.1 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.7 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.7 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.7 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.7 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 0.4 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.4 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.1 0.8 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.3 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.1 0.3 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.1 0.3 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.1 3.8 GO:0030674 protein binding, bridging(GO:0030674)
0.1 18.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.2 GO:0008238 exopeptidase activity(GO:0008238)
0.1 1.6 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 0.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 2.0 GO:0019901 protein kinase binding(GO:0019901)
0.1 0.3 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 2.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 0.3 GO:0022829 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.1 0.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 1.0 GO:0019904 protein domain specific binding(GO:0019904)
0.1 0.6 GO:0031072 heat shock protein binding(GO:0031072)
0.1 0.5 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.1 0.2 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.1 2.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.8 GO:0030276 clathrin binding(GO:0030276)
0.1 0.3 GO:0019201 nucleotide kinase activity(GO:0019201)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.2 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.1 1.2 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.8 GO:0051087 chaperone binding(GO:0051087)
0.1 1.1 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 0.2 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.1 0.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 0.2 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) thiol oxidase activity(GO:0016972)
0.0 0.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 2.8 GO:0003924 GTPase activity(GO:0003924)
0.0 1.6 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.3 GO:0010181 FMN binding(GO:0010181)
0.0 0.3 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.2 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.4 GO:0043495 protein anchor(GO:0043495)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.3 GO:0000049 tRNA binding(GO:0000049)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.5 GO:0019001 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.3 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.9 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0 0.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.1 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.4 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.5 GO:0003779 actin binding(GO:0003779)
0.0 0.1 GO:0060590 ATPase activator activity(GO:0001671) ATPase regulator activity(GO:0060590)
0.0 0.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0030295 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0008144 drug binding(GO:0008144)
0.0 0.1 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.2 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.2 GO:0005048 signal sequence binding(GO:0005048)
0.0 0.0 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.0 0.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.0 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.0 0.0 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.0 GO:0015665 alcohol transmembrane transporter activity(GO:0015665)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.4 1.1 PID CDC42 PATHWAY CDC42 signaling events
0.3 1.3 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.0 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.3 2.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 0.7 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.2 0.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.2 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 1.1 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 0.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 0.4 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 0.4 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.0 0.8 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.0 0.4 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0 0.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.0 0.1 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.0 0.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)