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Results for NHP6B

Z-value: 0.64

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Transcription factors associated with NHP6B

Gene Symbol Gene ID Gene Info
NHP6B
S000002157 High-mobility group (HMG) protein, binds to and remodels nucleosomes

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NHP6BYBR089C-A0.707.2e-05Click!

Activity profile of NHP6B motif

Sorted Z-values of NHP6B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YPR169W-A 2.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YKR034W 1.90
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YHR126C 1.11 Putative protein of unknown function; transcription dependent upon Azf1p
YKR033C 1.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80
YFL019C 1.02 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YMR107W 1.01
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YHR079C-A 1.01
SAE3
Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p
YKL221W 0.99
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YBR292C 0.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YPL026C 0.92
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YKL065W-A 0.83 Putative protein of unknown function
YJL149W 0.82
DAS1
Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C; null mutant suppresses dst1delta sensitivity for 6-azauracil
YLR307C-A 0.81 Putative protein of unknown function
YJR094C 0.81
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YDL210W 0.80
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YFL020C 0.77
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR446W 0.69
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YMR193C-A 0.68 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL205C 0.66
NCE101
Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
YHR096C 0.66
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YBR240C 0.65
THI2
Zinc finger protein of the Zn(II)2Cys6 type, probable transcriptional activator of thiamine biosynthetic genes
YPL187W 0.63
MF(ALPHA)1
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor
YGR039W 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YNL014W 0.61
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YLR308W 0.61
CDA2
Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YPL222C-A 0.60 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGL227W 0.58
VID30
Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); shifts the balance of nitrogen metabolism toward the production of glutamate; localized to the nucleus and the cytoplasm
YIL045W 0.56
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YML047C 0.56
PRM6
Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating
YAL062W 0.56
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YOL045W 0.56
PSK2
One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation)
YKL123W 0.55 Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4
YBR076C-A 0.55 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YBR157C 0.55
ICS2
Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YOL118C 0.54 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YPL156C 0.53
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YMR194C-B 0.52 Putative protein of unknown function
YLL046C 0.52
RNP1
Ribonucleoprotein that contains two RNA recognition motifs (RRM)
YDL138W 0.52
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YCL001W-B 0.51 Putative protein of unknown function; identified by homology
YJL150W 0.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCR007C 0.51 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YLL013C 0.50
PUF3
Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins
YEL014C 0.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR001W 0.49
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YBL033C 0.48
RIB1
GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway
YMR090W 0.48 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YDL139C 0.47
SCM3
Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; contains nuclear export signal (NES); required for G2/M progression and localization of Cse4p
YDR445C 0.47 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL211C 0.46 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YLR296W 0.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR171W 0.46
BSP1
Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YKL109W 0.45
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YPL024W 0.45
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YGL177W 0.45 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER167W 0.45
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YDL223C 0.44
HBT1
Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
YMR104C 0.44
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YDR504C 0.43
SPG3
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YHR217C 0.43 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YOL034W 0.43
SMC5
Structural maintenance of chromosomes (SMC) protein; essential subunit of the Mms21-Smc5-Smc6 complex; required for growth and DNA repair; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair
YMR195W 0.43
ICY1
Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
YML047W-A 0.42 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR056W 0.42
RSC1
Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
YKL177W 0.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YPR193C 0.40
HPA2
Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity
YNL180C 0.40
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YNL179C 0.40 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YOR062C 0.40 Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YLR124W 0.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL105C 0.40 Putative protein of unknown function
YDL130W-A 0.39
STF1
Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein
YMR204C 0.39
INP1
Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance
YOR192C-C 0.39 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YEL007W 0.37 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YBL067C 0.37
UBP13
Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YBR296C 0.37
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YBL097W 0.37
BRN1
Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics
YKR032W 0.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL117W 0.36 Putative protein of unknown function
YLR408C 0.36 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene
YCR001W 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene
YAR069C 0.36 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR467C 0.36 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR307W 0.35
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YJL116C 0.35
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YLR327C 0.35
TMA10
Protein of unknown function that associates with ribosomes
YHR095W 0.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YCL012C 0.35 Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene
YOL159C-A 0.35 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YPL020C 0.35
ULP1
Ubl (ubiquitin-like protein)-specific protease that cleaves Smt3p protein conjugates; specifically required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase
YLR309C 0.35
IMH1
Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi
YKL178C 0.34
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YLL019C 0.34
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YKL188C 0.33
PXA2
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YLR357W 0.33
RSC2
Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance
YML082W 0.33 Putative protein predicted to have carbon-sulfur lyase activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YNML082W is not an essential gene
YER121W 0.33 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YDR022C 0.33
CIS1
Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion
YKR039W 0.33
GAP1
General amino acid permease; localization to the plasma membrane is regulated by nitrogen source
YGR226C 0.33 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W
YAL066W 0.32 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR140W 0.32
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YPL258C 0.32
THI21
Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p
YOR139C 0.32 Hypothetical protein
YPR120C 0.32
CLB5
B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase
YER097W 0.32 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL197W 0.32
MDS3
Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions
YGR239C 0.32
PEX21
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YML068W 0.32
ITT1
Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins
YAR070C 0.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL025W 0.31
PAU17
Putative protein of unknown function; YLL025W is not an essential gene
YOL035C 0.31 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR011W-A 0.31 Putative protein of unknown function
YHR030C 0.31
SLT2
Serine/threonine MAP kinase involved in regulating the maintenance of cell wall integrity and progression through the cell cycle; regulated by the PKC1-mediated signaling pathway
YDL028C 0.31
MPS1
Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p
YBL053W 0.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR032W 0.30
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YAL067C 0.30
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YGR286C 0.30
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YFL033C 0.30
RIM15
Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
YKR009C 0.30
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YER187W 0.29 Putative protein of unknown function; induced in respiratory-deficient cells
YJR128W 0.29 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2
YGL170C 0.29
SPO74
Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YDR119W-A 0.29 Putative protein of unknown function
YMR118C 0.28 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YOR306C 0.28
MCH5
Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport
YJR048W 0.28
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR192C 0.28
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YJL135W 0.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
YHR205W 0.28
SCH9
Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB
YLR092W 0.27
SUL2
High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YCR066W 0.27
RAD18
Protein involved in postreplication repair; binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; forms heterodimer with Rad6p; contains RING-finger motif
YFL030W 0.27
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YER054C 0.27
GIP2
Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
YGR087C 0.27
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YAL063C 0.27
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YFL058W 0.27
THI5
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YDR389W 0.26
SAC7
GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
YDR369C 0.26
XRS2
Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
YKL110C 0.26
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YER129W 0.26
SAK1
Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YHR071W 0.26
PCL5
Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity
YER158W-A 0.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YDR223W 0.26
CRF1
Transcriptional corepressor involved in the regulation of ribosomal protein gene transcription via the TOR signaling pathway and protein kinase A, phosphorylated by activated Yak1p which promotes accumulation of Crf1p in the nucleus
YGR161C 0.25
RTS3
Putative component of the protein phosphatase type 2A complex
YGL096W 0.25
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YFL036W 0.25
RPO41
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YDL085W 0.25
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YPR006C 0.25
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YKL001C 0.25
MET14
Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YDL035C 0.25
GPR1
Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis
YBR184W 0.25 Putative protein of unknown function; YBR184W is not an essential gene
YOR178C 0.25
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YDR406W-A 0.25 Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR
YDR392W 0.24
SPT3
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
YOL113W 0.24
SKM1
Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; proposed to be a downstream effector of Cdc42p during polarized growth
YCL069W 0.24
VBA3
Permease of basic amino acids in the vacuolar membrane
YGL089C 0.24
MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YDR042C 0.24 Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YKR105C 0.24
VBA5
Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny
YHR164C 0.24
DNA2
Essential tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair pathways; potential Cdc28p substrate
YGR048W 0.24
UFD1
Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol
YBR242W 0.23 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YDL246C 0.23
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YKL106W 0.23
AAT1
Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis
YIL071C 0.23
PCI8
Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain
YBR291C 0.23
CTP1
Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
YOL051W 0.23
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YKL171W 0.23 Putative protein of unknown function; predicted protein kinase; implicated in proteasome function; epitope-tagged protein localizes to the cytoplasm
YDL027C 0.23 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene
YOR329W-A 0.23 Dubious open reading frame, unlikely to encode a functional protein; identified by fungal homology and RT-PCR
YNL171C 0.23 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGL036W 0.22 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene
YER014C-A 0.22
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YPR065W 0.22
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YKL066W 0.22 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
YJL200C 0.22
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YCL048W 0.22
SPS22
Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall
YGL118C 0.22 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPL027W 0.22
SMA1
Protein of unknown function involved in the assembly of the prospore membrane during sporulation
YOL112W 0.22
MSB4
GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization
YDL026W 0.22 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YER064C 0.22 Non-essential nuclear protein; null mutation has global effects on transcription
YNL103W 0.22
MET4
Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
YKR031C 0.22
SPO14
Phospholipase D, catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis
YNL036W 0.22
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YGR072W 0.22
UPF3
Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
YKL076C 0.21
PSY1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
YPL034W 0.21 Putative protein of unknown function; YPL034W is not essential gene
YNL267W 0.21
PIK1
Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton
YLR337C 0.21
VRP1
Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)
YLL012W 0.21
YEH1
Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
YEL045C 0.21 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress
YDR043C 0.21
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YDR421W 0.21
ARO80
Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids
YOL117W 0.21
RRI2
Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response
YDL007C-A 0.21 Putative protein of unknown function
YIL057C 0.21 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose

Network of associatons between targets according to the STRING database.

First level regulatory network of NHP6B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.3 0.8 GO:0051594 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.2 0.7 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.2 0.6 GO:0070623 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.2 1.0 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.2 0.2 GO:0042710 biofilm formation(GO:0042710)
0.2 0.7 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.2 0.5 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.2 0.5 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.2 0.7 GO:0015847 putrescine transport(GO:0015847)
0.2 0.5 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.2 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 0.8 GO:0051099 positive regulation of binding(GO:0051099)
0.1 0.7 GO:0051225 spindle assembly(GO:0051225)
0.1 0.4 GO:0008272 sulfate transport(GO:0008272)
0.1 0.8 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.1 0.9 GO:0034284 response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.1 1.2 GO:0070873 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.1 0.3 GO:0043419 urea catabolic process(GO:0043419)
0.1 0.7 GO:0001323 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.1 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.6 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.3 GO:0000304 response to singlet oxygen(GO:0000304)
0.1 0.3 GO:0015888 thiamine transport(GO:0015888)
0.1 0.3 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.1 0.3 GO:0045895 positive regulation of mating-type specific transcription, DNA-templated(GO:0045895)
0.1 0.4 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.1 0.4 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.1 0.3 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.1 0.9 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.5 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.1 0.6 GO:0070941 eisosome assembly(GO:0070941)
0.1 0.4 GO:1902222 L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1 0.3 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.1 0.3 GO:0045894 regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001196) negative regulation of mating-type specific transcription from RNA polymerase II promoter(GO:0001198) negative regulation of mating-type specific transcription, DNA-templated(GO:0045894)
0.1 0.1 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.1 0.3 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.1 0.3 GO:0000755 cytogamy(GO:0000755)
0.1 0.5 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.1 0.5 GO:0043457 regulation of cellular respiration(GO:0043457)
0.1 0.3 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.1 0.4 GO:0045033 peroxisome inheritance(GO:0045033)
0.1 0.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.2 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.1 0.2 GO:0043937 regulation of sporulation(GO:0043937)
0.1 0.3 GO:0015809 arginine transport(GO:0015809)
0.1 0.2 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.2 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 0.3 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.1 0.4 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151)
0.1 0.5 GO:0009306 protein secretion(GO:0009306)
0.1 0.2 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.1 0.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.1 0.4 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.3 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.1 0.7 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 0.4 GO:0070058 tRNA gene clustering(GO:0070058)
0.1 0.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.8 GO:0000767 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753) cell morphogenesis involved in conjugation(GO:0000767)
0.1 0.8 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.1 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.4 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.4 GO:0000706 meiotic DNA double-strand break processing(GO:0000706)
0.1 0.1 GO:1903322 positive regulation of protein ubiquitination(GO:0031398) positive regulation of protein modification by small protein conjugation or removal(GO:1903322)
0.1 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.2 GO:0015976 carbon utilization(GO:0015976)
0.1 0.2 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.1 0.1 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.1 0.3 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 0.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.1 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of mitotic nuclear division(GO:0045840) positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of proteasomal protein catabolic process(GO:1901800) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) positive regulation of proteolysis involved in cellular protein catabolic process(GO:1903052) positive regulation of cellular protein catabolic process(GO:1903364)
0.1 0.5 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.1 0.3 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.1 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.3 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 0.1 GO:0005993 trehalose catabolic process(GO:0005993)
0.0 0.2 GO:0034503 protein localization to nucleolar rDNA repeats(GO:0034503) rDNA condensation(GO:0070550)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.0 0.2 GO:0051180 vitamin transport(GO:0051180)
0.0 0.1 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.0 0.3 GO:0006276 plasmid maintenance(GO:0006276)
0.0 0.3 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.4 GO:0046686 response to cadmium ion(GO:0046686)
0.0 0.2 GO:0000272 polysaccharide catabolic process(GO:0000272)
0.0 0.4 GO:0070193 synaptonemal complex organization(GO:0070193)
0.0 0.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.1 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.0 0.3 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.0 GO:0043631 RNA polyadenylation(GO:0043631)
0.0 0.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.3 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.0 0.2 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.2 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.0 0.4 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.1 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.0 0.2 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.2 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.0 0.0 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.6 GO:0051666 actin cortical patch localization(GO:0051666)
0.0 0.1 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054) negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 0.1 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.0 0.2 GO:0019433 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.3 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0007129 synapsis(GO:0007129)
0.0 0.2 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.0 0.0 GO:1900182 positive regulation of protein localization to nucleus(GO:1900182) positive regulation of cellular protein localization(GO:1903829)
0.0 0.7 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 0.8 GO:0040020 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.0 0.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.3 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 0.3 GO:0060261 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.4 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:1904357 snoRNA transcription from an RNA polymerase II promoter(GO:0001015) negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.0 0.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0043335 protein unfolding(GO:0043335)
0.0 0.1 GO:0090069 regulation of ribosome biogenesis(GO:0090069) regulation of rRNA processing(GO:2000232)
0.0 0.2 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 0.2 GO:0015758 glucose transport(GO:0015758)
0.0 0.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.0 0.2 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.1 GO:0019346 transsulfuration(GO:0019346)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.1 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.1 GO:0006279 premeiotic DNA replication(GO:0006279)
0.0 0.1 GO:0015793 glycerol transport(GO:0015793)
0.0 0.1 GO:0042744 hydrogen peroxide metabolic process(GO:0042743) hydrogen peroxide catabolic process(GO:0042744)
0.0 0.3 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0097271 protein localization to bud neck(GO:0097271)
0.0 0.0 GO:0044773 mitotic DNA damage checkpoint(GO:0044773)
0.0 0.5 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546)
0.0 0.4 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.0 0.1 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.1 GO:0022604 regulation of cell morphogenesis(GO:0022604)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.2 GO:0031578 mitotic spindle orientation checkpoint(GO:0031578)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.8 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.1 GO:0071025 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.1 GO:0043200 response to amino acid(GO:0043200)
0.0 0.0 GO:0071168 establishment of protein localization to chromosome(GO:0070199) protein localization to chromatin(GO:0071168) establishment of protein localization to chromatin(GO:0071169)
0.0 0.2 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.2 GO:0015846 polyamine transport(GO:0015846)
0.0 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.1 GO:0071241 cellular response to inorganic substance(GO:0071241)
0.0 0.1 GO:0016574 histone ubiquitination(GO:0016574)
0.0 0.0 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 0.1 GO:0031331 positive regulation of cellular catabolic process(GO:0031331)
0.0 0.4 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.0 0.1 GO:0046113 nucleobase catabolic process(GO:0046113)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.7 GO:0042244 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.0 0.1 GO:0002376 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.0 0.8 GO:0016573 internal protein amino acid acetylation(GO:0006475) histone acetylation(GO:0016573) internal peptidyl-lysine acetylation(GO:0018393) peptidyl-lysine acetylation(GO:0018394)
0.0 0.2 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0051596 methylglyoxal metabolic process(GO:0009438) methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.0 0.1 GO:0046503 glycerophospholipid catabolic process(GO:0046475) glycerolipid catabolic process(GO:0046503)
0.0 0.6 GO:0000725 recombinational repair(GO:0000725)
0.0 0.1 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.0 0.1 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.0 0.0 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.6 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.1 GO:0019692 deoxyribose phosphate metabolic process(GO:0019692)
0.0 0.1 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0 0.1 GO:0015696 ammonium transport(GO:0015696)
0.0 0.0 GO:0016242 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.0 0.2 GO:0007533 mating type switching(GO:0007533)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0007032 endosome organization(GO:0007032)
0.0 0.1 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.0 0.0 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.0 0.1 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.0 0.1 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.2 GO:0031990 mRNA export from nucleus in response to heat stress(GO:0031990)
0.0 0.0 GO:0046185 aldehyde catabolic process(GO:0046185)
0.0 0.2 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.0 GO:0001927 exocyst assembly(GO:0001927)
0.0 0.5 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 0.5 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 0.0 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.2 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0031929 TOR signaling(GO:0031929)
0.0 0.1 GO:0010529 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.4 GO:0044843 G1/S transition of mitotic cell cycle(GO:0000082) cell cycle G1/S phase transition(GO:0044843)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.1 GO:0048278 vesicle docking(GO:0048278)
0.0 0.1 GO:0030952 establishment or maintenance of actin cytoskeleton polarity(GO:0030950) establishment or maintenance of cytoskeleton polarity(GO:0030952)
0.0 0.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.0 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.0 0.1 GO:0000103 sulfate assimilation(GO:0000103)
0.0 0.1 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.0 0.2 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.2 GO:0009408 response to heat(GO:0009408)
0.0 0.1 GO:0043633 polyadenylation-dependent RNA catabolic process(GO:0043633)
0.0 0.0 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.0 0.0 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:0018202 peptidyl-histidine modification(GO:0018202)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.0 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.2 0.9 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.1 0.9 GO:0034657 GID complex(GO:0034657)
0.1 0.5 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.4 GO:0032116 SMC loading complex(GO:0032116)
0.1 0.3 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.4 GO:0005771 multivesicular body(GO:0005771)
0.1 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.3 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.6 GO:0000795 synaptonemal complex(GO:0000795)
0.1 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.5 GO:0051233 spindle midzone(GO:0051233)
0.1 0.5 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.1 0.4 GO:0000133 polarisome(GO:0000133)
0.1 0.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.2 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.9 GO:0016586 RSC complex(GO:0016586)
0.0 0.2 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.2 GO:0033551 monopolin complex(GO:0033551)
0.0 0.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.0 0.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.5 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.6 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.2 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 0.0 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.8 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.0 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.5 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753) proton-transporting ATP synthase complex(GO:0045259)
0.0 0.2 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.2 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.0 0.1 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.0 0.1 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.0 1.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.0 0.5 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.1 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.4 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.0 0.1 GO:0031160 ascospore wall(GO:0005619) spore wall(GO:0031160)
0.0 0.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 0.1 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.0 0.2 GO:0005875 microtubule associated complex(GO:0005875)
0.0 0.1 GO:0070211 Snt2C complex(GO:0070211)
0.0 0.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.1 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.0 GO:0044697 HICS complex(GO:0044697)
0.0 0.1 GO:0032221 Rpd3S complex(GO:0032221)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)
0.0 0.1 GO:0030897 HOPS complex(GO:0030897)
0.0 0.0 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.0 0.1 GO:0016459 myosin complex(GO:0016459)
0.0 0.1 GO:0045281 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.1 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.0 GO:0000124 SAGA complex(GO:0000124) SAGA-type complex(GO:0070461)
0.0 0.3 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.1 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.0 1.3 GO:0042995 mating projection(GO:0005937) cell projection(GO:0042995)
0.0 0.3 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.0 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0035097 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.0 GO:0097196 Shu complex(GO:0097196)
0.0 0.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.0 GO:0033255 SAS acetyltransferase complex(GO:0033255)
0.0 0.2 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.0 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.0 GO:0070274 RES complex(GO:0070274)
0.0 0.0 GO:0005956 protein kinase CK2 complex(GO:0005956)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.3 0.8 GO:0005536 glucose binding(GO:0005536)
0.2 0.7 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.2 0.6 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 0.6 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.2 0.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.2 0.6 GO:0005537 mannose binding(GO:0005537)
0.1 0.4 GO:0032183 SUMO binding(GO:0032183)
0.1 0.4 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.1 0.5 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.1 0.5 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.4 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.1 0.4 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.1 0.6 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.3 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.1 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.6 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.1 0.8 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.3 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 0.8 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 1.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 0.2 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 0.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 0.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.3 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1 0.2 GO:0016880 acid-ammonia (or amide) ligase activity(GO:0016880)
0.1 0.2 GO:0016289 CoA hydrolase activity(GO:0016289)
0.1 0.2 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.3 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 0.3 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 0.3 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.1 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 0.2 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.1 0.1 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.1 0.3 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.3 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.1 1.1 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.1 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.0 0.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.9 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.1 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.0 6.4 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
0.0 0.1 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.0 0.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.0 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0 0.3 GO:0001031 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.2 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 3.9 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.1 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.8 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.1 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.0 0.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.5 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.1 GO:0005034 osmosensor activity(GO:0005034)
0.0 0.1 GO:0070336 flap-structured DNA binding(GO:0070336)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.6 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.3 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.7 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.1 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.0 0.5 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.7 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 0.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0 0.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.3 GO:0015578 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.0 0.1 GO:0004375 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.0 1.4 GO:0000988 transcription factor activity, protein binding(GO:0000988)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.0 0.0 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.0 0.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.2 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.0 0.1 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.0 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.0 0.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.0 GO:0004771 sterol esterase activity(GO:0004771)
0.0 0.1 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.2 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.7 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.0 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.1 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.2 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.3 GO:0042393 histone binding(GO:0042393)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.0 GO:0000217 DNA secondary structure binding(GO:0000217)
0.0 0.0 GO:0019208 phosphatase regulator activity(GO:0019208)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.0 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0 0.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.0 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.0 0.0 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.1 GO:0016896 exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0 0.0 GO:0004100 chitin synthase activity(GO:0004100)
0.0 0.1 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.0 GO:0072341 modified amino acid binding(GO:0072341)
0.0 0.7 GO:0005543 phospholipid binding(GO:0005543)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 0.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 0.2 PID ATR PATHWAY ATR signaling pathway
0.0 0.4 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.1 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.1 PID MYC PATHWAY C-MYC pathway
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 23.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.0 PID FOXO PATHWAY FoxO family signaling
0.0 0.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.1 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 0.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 0.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 0.1 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.2 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 0.1 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.1 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.2 REACTOME MEIOSIS Genes involved in Meiosis
0.0 0.0 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.0 0.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.1 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME RNA POL II TRANSCRIPTION Genes involved in RNA Polymerase II Transcription
0.0 23.1 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.0 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle