Results for MIG3
Z-value: 1.44
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Transcription factors associated with MIG3
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MIG3
|
S000000830 | Transcriptional regulator |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YDR342C Show fit | 25.67 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels |
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| YGR067C Show fit | 21.67 |
Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p |
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| YGR243W Show fit | 17.30 |
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
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| YNR073C Show fit | 13.68 |
Putative mannitol dehydrogenase |
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| YDR536W Show fit | 12.28 |
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock |
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| YFR053C Show fit | 12.16 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YDR343C Show fit | 11.85 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 |
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| YOR100C Show fit | 11.62 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YMR107W Show fit | 11.53 |
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources |
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| YLR327C Show fit | 11.40 |
Protein of unknown function that associates with ribosomes |
Network of associatons between targets according to the STRING database.
First level regulatory network of MIG3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 28.3 | GO:0006848 | pyruvate transport(GO:0006848) |
| 1.3 | 27.8 | GO:0008645 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 2.8 | 25.3 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.2 | 17.8 | GO:0005978 | glycogen biosynthetic process(GO:0005978) |
| 1.3 | 13.5 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.8 | 13.5 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.3 | 13.5 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.5 | 13.2 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.9 | 13.1 | GO:0000436 | carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436) |
| 2.5 | 12.7 | GO:0019405 | alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 57.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.3 | 50.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.4 | 21.9 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.7 | 13.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 1.3 | 11.6 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 1.9 | 9.7 | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.5 | 9.2 | GO:0031307 | intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307) |
| 0.8 | 9.0 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.1 | 7.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 1.6 | 6.4 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 25.6 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.2 | 20.1 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 5.6 | 16.9 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 1.1 | 13.8 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 1.1 | 12.2 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.2 | 11.5 | GO:0016614 | oxidoreductase activity, acting on CH-OH group of donors(GO:0016614) |
| 0.9 | 11.4 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 2.7 | 10.7 | GO:0005537 | mannose binding(GO:0005537) |
| 0.6 | 10.7 | GO:0020037 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 1.3 | 10.4 | GO:0016679 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 61.1 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.8 | 5.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.8 | 4.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 3.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.1 | 3.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 1.4 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 0.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 0.4 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 0.2 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 0.2 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 60.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.3 | 14.6 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.7 | 3.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.7 | 3.0 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.5 | 1.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.3 | 1.0 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.3 | 0.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.0 | 0.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 0.4 | REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | Genes involved in Transmembrane transport of small molecules |
| 0.1 | 0.1 | REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | Genes involved in The citric acid (TCA) cycle and respiratory electron transport |