Navigation
Downloads

Results for MIG1

Z-value: 1.45

Motif logo

logo of

Transcription factors associated with MIG1

Gene Symbol Gene ID Gene Info
MIG1
S000003003 Transcription factor involved in glucose repression

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MIG1YGL035C0.096.7e-01Click!

Activity profile of MIG1 motif

Sorted Z-values of MIG1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YDR342C 19.01
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YJL133C-A 17.91 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR067C 17.62 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YDL210W 15.41
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YPR030W 13.89
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YFL052W 13.20 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YIL162W 13.03
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YLR327C 12.50
TMA10
Protein of unknown function that associates with ribosomes
YAR035W 12.32
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YFR053C 11.30
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YIL057C 11.15 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPR184W 9.90
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YKL217W 9.78
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YAL062W 9.53
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YOR178C 9.38
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YNR073C 8.62 Putative mannitol dehydrogenase
YER084W 8.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR277C 8.16
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YJR115W 7.87 Putative protein of unknown function
YOR100C 7.78
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YOR374W 7.73
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YDR059C 7.52
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YGR243W 7.51
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL244W 7.42
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YOL052C-A 7.15
DDR2
Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses
YOR343C 7.05 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YML089C 6.83 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YNR034W-A 6.72 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YBR297W 6.62
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YDR536W 6.43
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YLR174W 6.24
IDP2
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
YOR383C 6.07
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YNL052W 5.79
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YHR092C 5.78
HXT4
High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose
YOR393W 5.67
ERR1
Protein of unknown function, has similarity to enolases
YLR023C 5.65
IZH3
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
YJR095W 5.60
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YOR235W 5.53
IRC13
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YMR081C 5.46
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YPR150W 5.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C
YLR377C 5.35
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YCR091W 5.23
KIN82
Putative serine/threonine protein kinase, most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily
YBR201C-A 5.22 Putative protein of unknown function
YBL048W 5.18 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data
YFL051C 5.16 Putative protein of unknown function; YFL051C is not an essential gene
YGL062W 5.12
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YCL001W-B 4.99 Putative protein of unknown function; identified by homology
YDR216W 4.87
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YPR013C 4.79 Putative zinc finger protein; YPR013C is not an essential gene
YOL051W 4.75
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YLR149C 4.68 Putative protein of unknown function; YLR149C is not an essential gene
YOR065W 4.65
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YPR010C-A 4.55 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YEL011W 4.54
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YOR382W 4.52
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YPL061W 4.46
ALD6
Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress
YGR043C 4.45
NQM1
Protein of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; null mutant non-quiescent cells exhibit reduced reproductive capacity
YNL144C 4.39 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YDL194W 4.36
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YFL036W 4.35
RPO41
Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition
YMR107W 4.27
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLR122C 4.18 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YDR018C 4.15 Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YCL054W 4.14
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YML090W 4.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YGR183C 4.13
QCR9
Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
YPL024W 4.09
RMI1
Involved in response to DNA damage; null mutants have increased rates of recombination and delayed S phase; interacts physically and genetically with Sgs1p (RecQ family member) and Top3p (topoisomerase III)
YGL146C 4.05 Putative protein of unknown function, contains two putative transmembrane spans, shows no significant homology to any other known protein sequence, YGL146C is not an essential gene
YPR015C 4.03 Putative protein of unknown function
YBR051W 3.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YJL130C 3.97
URA2
Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
YDR119W-A 3.91 Putative protein of unknown function
YDR178W 3.90
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YBR050C 3.90
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YPR005C 3.87
HAL1
Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p
YDL245C 3.86
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YEL049W 3.82
PAU2
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YNL036W 3.80
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YGR066C 3.75 Putative protein of unknown function
YHR033W 3.73 Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm
YKL093W 3.71
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YAL039C 3.66
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YOR391C 3.65
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YPR065W 3.59
ROX1
Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
YLR123C 3.58 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YER067W 3.55 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YER067W is not an essential gene
YKR102W 3.52
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YIL024C 3.51 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YML042W 3.50
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YPL026C 3.49
SKS1
Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway
YBR203W 3.46
COS111
Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YAL060W 3.43
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YNL117W 3.43
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YJR151C 3.41
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YLR312C 3.40
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YGL033W 3.38
HOP2
Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
YDR096W 3.36
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YBL064C 3.28
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YML091C 3.24
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YAR050W 3.22
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YNL142W 3.21
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YDL079C 3.21
MRK1
Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation
YEL070W 3.19
DSF1
Deletion suppressor of mpt5 mutation
YHL021C 3.17
AIM17
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YER065C 3.11
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YHR211W 3.05
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YHL032C 3.05
GUT1
Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p
YPL248C 3.04
GAL4
DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p
YEL009C-A 2.97 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR095W 2.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR049W 2.89
YMR31
Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36
YJL116C 2.88
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YER121W 2.88 Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YEL008W 2.85 Hypothetical protein predicted to be involved in metabolism
YDL169C 2.85
UGX2
Protein of unknown function, transcript accumulates in response to any combination of stress conditions
YLR142W 2.83
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YOR152C 2.82 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YEL009C 2.81
GCN4
Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YNL018C 2.78 Putative protein of unknown function
YCR010C 2.77
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YGL180W 2.74
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YGR258C 2.74
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YKL163W 2.74
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YMR105C 2.72
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YER150W 2.69
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YAL063C 2.67
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YBR033W 2.66
EDS1
Putative zinc cluster protein; YBR033W is not an essential gene
YLR124W 2.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL163C 2.62
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YJR160C 2.58
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YOL081W 2.57
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YPR002W 2.56
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YMR194C-B 2.56 Putative protein of unknown function
YAR047C 2.54 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNR002C 2.49
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBL015W 2.46
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YKL031W 2.45 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YLR273C 2.42
PIG1
Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
YCL025C 2.40
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YOR328W 2.38
PDR10
ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p
YLR279W 2.35 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL082W 2.35
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YJL045W 2.34 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YKL109W 2.32
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YPR151C 2.31
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YGR023W 2.31
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YNL077W 2.28
APJ1
Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR393W 2.27
ATP10
Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6
YJR121W 2.25
ATP2
Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YDR343C 2.22
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YPR006C 2.21
ICL2
2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol
YBR132C 2.20
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YGR022C 2.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YEL012W 2.19
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YLR037C 2.17
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YEL010W 2.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL143C 2.13 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL199C 2.12
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YPL186C 2.12
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YFL011W 2.12
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YBR105C 2.11
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YOR245C 2.11
DGA1
Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
YPL089C 2.10
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YFL055W 2.09
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YDR034C 2.06
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YOR120W 2.06
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YLR125W 2.06 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YJL100W 2.05
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YDR085C 2.04
AFR1
Alpha-factor pheromone receptor regulator, negatively regulates pheromone receptor signaling; required for normal mating projection (shmoo) formation; required for Spa2p to recruit Mpk1p to shmoo tip during mating; interacts with Cdc12p
YCR073W-A 2.02
SOL2
Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p
YDL214C 2.00
PRR2
Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor
YOR394W 2.00
PAU21
Hypothetical protein
YMR017W 1.99
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YDR441C 1.98
APT2
Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity
YOR236W 1.96
DFR1
Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function
YNL037C 1.94
IDH1
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YAL067C 1.94
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YBL045C 1.91
COR1
Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain
YOR392W 1.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YPL230W 1.89
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YFL019C 1.89 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YOR376W 1.89 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene.
YFR017C 1.88 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YDR043C 1.86
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YER187W 1.86 Putative protein of unknown function; induced in respiratory-deficient cells
YPL185W 1.86 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YLL039C 1.85
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YOR388C 1.85
FDH1
NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate
YIR027C 1.84
DAL1
Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression
YIL060W 1.84 Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YPR196W 1.83 Putative maltose activator
YPL282C 1.81
PAU22
Hypothetical protein
YPR049C 1.80
ATG11
Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the pro-autophagosomal structure (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS
YFL054C 1.79 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YHR080C 1.78 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL034W 1.77 Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
YER014C-A 1.76
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YKL168C 1.76
KKQ8
Putative serine/threonine protein kinase with unknown cellular role
YKL188C 1.75
PXA2
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YMR104C 1.75
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK

Network of associatons between targets according to the STRING database.

First level regulatory network of MIG1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 15.8 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
4.9 4.9 GO:0034310 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310)
4.4 13.1 GO:0015755 fructose transport(GO:0015755)
4.2 16.7 GO:0015847 putrescine transport(GO:0015847)
4.1 12.2 GO:0019413 acetate biosynthetic process(GO:0019413)
3.7 14.9 GO:0006848 pyruvate transport(GO:0006848)
2.4 12.1 GO:0005980 glycogen catabolic process(GO:0005980)
2.2 13.0 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
2.1 12.8 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
2.1 14.6 GO:0000023 maltose metabolic process(GO:0000023)
1.9 5.7 GO:0019543 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
1.7 5.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
1.7 5.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
1.6 8.2 GO:0006102 isocitrate metabolic process(GO:0006102)
1.6 14.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
1.6 4.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
1.4 4.3 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
1.3 10.5 GO:0015891 siderophore transport(GO:0015891)
1.3 7.6 GO:0006097 glyoxylate cycle(GO:0006097)
1.2 21.2 GO:0005978 glycogen biosynthetic process(GO:0005978)
1.2 3.7 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
1.2 4.8 GO:0015976 carbon utilization(GO:0015976)
1.1 3.2 GO:0072488 ammonium transmembrane transport(GO:0072488)
1.0 4.2 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
1.0 4.1 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
1.0 10.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.0 4.8 GO:0015793 glycerol transport(GO:0015793)
0.9 2.8 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.9 6.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.9 3.7 GO:0009190 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.8 3.3 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.8 3.3 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.8 3.9 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.8 3.1 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.7 0.7 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.7 2.1 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.7 2.1 GO:0042843 D-xylose catabolic process(GO:0042843)
0.7 2.1 GO:0006545 glycine biosynthetic process(GO:0006545)
0.7 6.1 GO:0045332 phospholipid translocation(GO:0045332)
0.7 2.0 GO:0044209 AMP salvage(GO:0044209)
0.7 3.3 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.6 1.9 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.6 6.0 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.6 5.7 GO:0009743 response to carbohydrate(GO:0009743)
0.6 5.7 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.6 9.5 GO:0042724 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.6 2.2 GO:0006083 acetate metabolic process(GO:0006083)
0.5 2.7 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.5 1.6 GO:0033499 galactose catabolic process(GO:0019388) galactose catabolic process via UDP-galactose(GO:0033499)
0.5 4.8 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.5 4.1 GO:0031167 rRNA methylation(GO:0031167)
0.5 5.1 GO:0046686 response to cadmium ion(GO:0046686)
0.5 2.0 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.5 1.0 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.5 0.5 GO:1904951 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.5 1.5 GO:0071050 snoRNA polyadenylation(GO:0071050)
0.5 9.6 GO:0000209 protein polyubiquitination(GO:0000209)
0.5 1.4 GO:0015888 thiamine transport(GO:0015888)
0.5 1.8 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.4 1.8 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.4 0.9 GO:0008272 sulfate transport(GO:0008272)
0.4 1.3 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.4 6.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.4 2.1 GO:0006071 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.4 1.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 2.4 GO:0000256 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.4 5.1 GO:0046173 polyol biosynthetic process(GO:0046173)
0.4 3.8 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.4 1.5 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.4 1.1 GO:0008216 spermidine metabolic process(GO:0008216)
0.4 1.4 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.4 1.4 GO:0090294 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.3 4.3 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.3 2.0 GO:0006089 lactate metabolic process(GO:0006089)
0.3 0.7 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.3 1.3 GO:0015886 heme transport(GO:0015886)
0.3 0.6 GO:0042775 respiratory electron transport chain(GO:0022904) ATP synthesis coupled electron transport(GO:0042773) mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.3 3.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 1.2 GO:0035968 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.3 2.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.3 0.6 GO:0046185 aldehyde catabolic process(GO:0046185)
0.3 2.5 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.3 0.8 GO:0000101 sulfur amino acid transport(GO:0000101)
0.3 1.9 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.3 0.8 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.3 0.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993)
0.2 0.5 GO:0006537 glutamate metabolic process(GO:0006536) glutamate biosynthetic process(GO:0006537)
0.2 0.2 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.2 9.6 GO:0009060 aerobic respiration(GO:0009060)
0.2 2.4 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.2 3.9 GO:0007129 synapsis(GO:0007129)
0.2 0.8 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.2 2.8 GO:0006757 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.2 1.2 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.2 1.2 GO:0015851 nucleobase transport(GO:0015851)
0.2 2.6 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.2 0.9 GO:0031507 heterochromatin assembly(GO:0031507)
0.2 3.2 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.2 0.9 GO:0032973 amino acid export(GO:0032973) amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.2 0.2 GO:1901678 iron coordination entity transport(GO:1901678)
0.2 0.5 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 0.9 GO:0070941 eisosome assembly(GO:0070941)
0.2 3.0 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.2 0.5 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.2 0.8 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.2 0.2 GO:0006824 cobalt ion transport(GO:0006824)
0.2 0.6 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.1 1.0 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 1.6 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.2 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.1 0.4 GO:0071281 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.1 0.5 GO:0030969 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.1 0.4 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 0.4 GO:0071456 cellular response to hypoxia(GO:0071456)
0.1 4.8 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 2.8 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.5 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.1 1.3 GO:0016925 protein sumoylation(GO:0016925)
0.1 0.6 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.6 GO:0070124 mitochondrial translational initiation(GO:0070124)
0.1 1.6 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.1 0.4 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 2.3 GO:0022900 electron transport chain(GO:0022900)
0.1 0.2 GO:0051098 regulation of binding(GO:0051098)
0.1 1.9 GO:0031503 protein complex localization(GO:0031503)
0.1 0.3 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 0.2 GO:0006020 inositol metabolic process(GO:0006020)
0.1 0.3 GO:0032056 positive regulation of translation in response to stress(GO:0032056)
0.1 0.2 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.1 0.9 GO:0006826 iron ion transport(GO:0006826)
0.1 1.6 GO:0001101 response to acid chemical(GO:0001101)
0.1 0.6 GO:0046020 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.1 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.8 GO:0051181 cofactor transport(GO:0051181)
0.1 0.4 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.3 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.1 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.0 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 1.6 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.4 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.1 0.2 GO:0052547 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 0.5 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.1 0.8 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.1 0.1 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.1 0.3 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 1.3 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.2 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.3 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.4 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.4 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.3 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.2 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979)
0.1 0.6 GO:0009092 homoserine metabolic process(GO:0009092)
0.1 0.1 GO:0001323 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.1 0.2 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.2 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.1 0.2 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.2 GO:0055088 lipid homeostasis(GO:0055088)
0.1 0.3 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.1 GO:0051204 protein insertion into mitochondrial membrane(GO:0051204)
0.1 0.6 GO:0009968 negative regulation of signal transduction(GO:0009968) negative regulation of signaling(GO:0023057)
0.1 0.3 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.1 0.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.2 GO:0000196 MAPK cascade involved in cell wall organization or biogenesis(GO:0000196)
0.0 0.6 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.1 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.1 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.0 1.5 GO:0042176 regulation of protein catabolic process(GO:0042176)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 1.5 GO:0070591 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.0 0.7 GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress(GO:0036003)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.4 GO:0015893 drug transport(GO:0015893)
0.0 0.4 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.0 0.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.3 GO:0045143 homologous chromosome segregation(GO:0045143)
0.0 0.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.5 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.0 0.2 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.0 0.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.0 0.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
0.0 0.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.3 GO:0042493 response to drug(GO:0042493)
0.0 0.2 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.0 GO:0045117 azole transport(GO:0045117)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.3 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.1 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.0 0.1 GO:0000114 obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114)
0.0 0.0 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085) acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.0 0.2 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.1 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.1 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.3 GO:0048278 vesicle docking(GO:0048278)
0.0 0.2 GO:0006284 base-excision repair(GO:0006284)
0.0 0.1 GO:0000076 DNA replication checkpoint(GO:0000076)
0.0 0.2 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.0 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.0 0.2 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.0 GO:0035822 meiotic gene conversion(GO:0006311) gene conversion(GO:0035822)
0.0 0.1 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 16.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.4 4.1 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
1.2 11.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.9 2.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.9 2.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.8 7.6 GO:0070069 cytochrome complex(GO:0070069)
0.8 3.9 GO:0005746 mitochondrial respiratory chain(GO:0005746) mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) respiratory chain complex(GO:0098803)
0.7 2.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.7 3.3 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.7 3.3 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.6 2.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.6 2.5 GO:0070469 respiratory chain(GO:0070469)
0.6 12.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.5 3.6 GO:0042597 periplasmic space(GO:0042597)
0.4 21.5 GO:0031225 anchored component of membrane(GO:0031225)
0.4 2.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.4 4.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 1.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 1.7 GO:0001400 mating projection base(GO:0001400)
0.3 2.3 GO:0034657 GID complex(GO:0034657)
0.3 2.9 GO:0030677 ribonuclease P complex(GO:0030677)
0.3 3.1 GO:0005619 ascospore wall(GO:0005619)
0.3 0.8 GO:0030870 Mre11 complex(GO:0030870)
0.3 12.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 40.8 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.3 5.1 GO:0070847 core mediator complex(GO:0070847)
0.2 8.3 GO:0005576 extracellular region(GO:0005576)
0.2 2.9 GO:0031307 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.2 0.4 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.2 0.9 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.2 1.0 GO:0009277 fungal-type cell wall(GO:0009277)
0.2 1.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 0.6 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.8 GO:0033263 CORVET complex(GO:0033263)
0.1 2.6 GO:0005811 lipid particle(GO:0005811)
0.1 0.2 GO:0070985 TFIIK complex(GO:0070985)
0.1 1.7 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 0.7 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.1 16.3 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 1.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 69.7 GO:0005739 mitochondrion(GO:0005739)
0.1 5.2 GO:0000502 proteasome complex(GO:0000502)
0.1 0.4 GO:0008623 CHRAC(GO:0008623)
0.1 0.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.3 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1 0.5 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 1.4 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.9 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.2 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.3 GO:0033551 monopolin complex(GO:0033551)
0.1 0.4 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 0.2 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 0.2 GO:0033309 SBF transcription complex(GO:0033309)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.2 GO:0033101 cellular bud membrane(GO:0033101)
0.0 0.5 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.2 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.0 0.3 GO:0034967 Set3 complex(GO:0034967)
0.0 0.5 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.0 0.1 GO:0005884 actin filament(GO:0005884)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 33.4 GO:0015295 solute:proton symporter activity(GO:0015295)
5.3 15.8 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
4.7 14.2 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
3.3 9.9 GO:0090599 alpha-glucosidase activity(GO:0090599)
3.1 12.5 GO:0005537 mannose binding(GO:0005537)
2.4 9.7 GO:0004396 hexokinase activity(GO:0004396)
2.1 6.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.0 12.2 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
1.7 3.5 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
1.7 5.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.6 4.8 GO:0005536 glucose binding(GO:0005536)
1.5 6.0 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
1.5 6.0 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.3 4.0 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.3 3.9 GO:0048038 quinone binding(GO:0048038)
1.3 5.0 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
1.2 15.0 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
1.2 5.0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
1.2 4.7 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091) TFIIH-class transcription factor binding(GO:0001097)
1.1 3.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
1.1 14.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
1.0 4.1 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
1.0 1.9 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.9 2.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.9 2.6 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.9 2.6 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.8 2.5 GO:0016289 CoA hydrolase activity(GO:0016289)
0.8 6.4 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.8 5.4 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.8 7.6 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.8 3.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.7 1.3 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.6 3.9 GO:0000400 four-way junction DNA binding(GO:0000400)
0.6 2.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.6 6.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.5 7.1 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.5 1.6 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.5 2.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.5 2.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.5 1.5 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.5 2.0 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.5 3.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.5 7.7 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.5 1.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 1.8 GO:0016411 acylglycerol O-acyltransferase activity(GO:0016411)
0.4 4.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.4 0.9 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.4 3.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.4 1.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.4 2.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.4 9.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.4 1.8 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.4 1.1 GO:0015294 solute:cation symporter activity(GO:0015294)
0.3 1.7 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.3 0.9 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 1.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.3 2.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 1.7 GO:0030246 carbohydrate binding(GO:0030246)
0.3 1.7 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.3 0.8 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.3 2.4 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 1.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.3 0.8 GO:0015293 symporter activity(GO:0015293)
0.3 1.8 GO:0008379 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.3 2.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.3 0.8 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.2 2.0 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.2 6.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 1.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 3.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.2 1.3 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 0.9 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.2 0.2 GO:0005346 purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.2 2.6 GO:0015616 DNA translocase activity(GO:0015616)
0.2 5.6 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.2 0.7 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.2 0.5 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.8 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.2 0.6 GO:0016531 copper chaperone activity(GO:0016531)
0.2 0.6 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 0.8 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.2 1.8 GO:0032947 protein complex scaffold(GO:0032947)
0.1 2.1 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.1 0.4 GO:0004672 protein kinase activity(GO:0004672)
0.1 0.6 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 1.3 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 1.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.1 GO:0015297 antiporter activity(GO:0015297)
0.1 1.9 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.1 0.1 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 1.1 GO:0099600 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.1 14.0 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 0.4 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 12.8 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.9 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.2 GO:0001026 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 0.5 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.1 0.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.3 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 1.1 GO:0005199 structural constituent of cell wall(GO:0005199)
0.1 0.7 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.4 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.1 0.8 GO:0005507 copper ion binding(GO:0005507)
0.1 0.2 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 0.6 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.1 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 0.1 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.1 0.2 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 0.3 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.1 0.2 GO:0045118 azole transporter activity(GO:0045118)
0.1 0.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 0.2 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.9 GO:0051020 GTPase binding(GO:0051020)
0.1 0.3 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 2.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.1 GO:0004180 carboxypeptidase activity(GO:0004180)
0.0 0.5 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 1.2 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 0.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.6 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0008374 O-acyltransferase activity(GO:0008374)
0.0 1.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.8 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.5 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.1 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.5 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.1 GO:0050661 NADP binding(GO:0050661)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.9 2.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.6 1.9 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.5 4.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 1.6 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 0.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 0.4 PID P73PATHWAY p73 transcription factor network
0.1 96.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.0 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.6 1.9 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.5 1.9 REACTOME DOUBLE STRAND BREAK REPAIR Genes involved in Double-Strand Break Repair
0.5 5.0 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.3 0.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 0.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 3.3 REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS Genes involved in Metabolism of lipids and lipoproteins
0.1 0.7 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.5 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.1 94.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.3 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.0 0.3 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.2 REACTOME TRANSCRIPTION Genes involved in Transcription