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Results for MET32

Z-value: 1.60

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Transcription factors associated with MET32

Gene Symbol Gene ID Gene Info
MET32
S000002661 Zinc-finger DNA-binding transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MET32YDR253C0.491.0e-02Click!

Activity profile of MET32 motif

Sorted Z-values of MET32 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YPL250C 12.20
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YIL162W 10.69
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YLR327C 10.41
TMA10
Protein of unknown function that associates with ribosomes
YNL014W 9.57
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YBR072W 9.50
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YPL054W 9.37
LEE1
Zinc-finger protein of unknown function
YGL184C 9.34
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YAR053W 8.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL056C 8.70 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YDL210W 8.68
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YOR383C 8.64
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YHL036W 8.56
MUP3
Low affinity methionine permease, similar to Mup1p
YJR146W 8.08 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YLL055W 7.82
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YKL217W 7.54
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YML089C 6.99 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YGR258C 6.97
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YDL085W 6.89
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YHR145C 6.88 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YAR060C 6.76 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR296C 6.63
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YLR149C 6.52 Putative protein of unknown function; YLR149C is not an essential gene
YFL052W 6.52 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YHR212C 6.49 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL116C 6.21
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YMR081C 6.07
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YHR212W-A 5.65 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YBR045C 5.61
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YLL061W 5.53
MMP1
High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
YKL031W 5.45 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YOL051W 5.42
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YAL067C 5.37
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YLR438W 5.12
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YOR378W 5.09 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YCR005C 4.83
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YOL163W 4.81 Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family
YLL060C 4.80
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YPR027C 4.75 Putative protein of unknown function
YJL199C 4.72
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YNL277W 4.68
MET2
L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway
YKR034W 4.62
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YPL186C 4.59
UIP4
Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope
YFL055W 4.57
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YEL059W 4.55 Dubious open reading frame unlikely to encode a functional protein
YBR077C 4.50
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YLR437C-A 4.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YMR107W 4.40
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR040W 4.37
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YFL011W 4.36
HXT10
Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YLR402W 4.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL180W 4.23
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YIL102C 4.17 Putative protein of unknown function
YLR403W 4.13
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YML090W 4.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YPL185W 4.09 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C
YAR050W 3.97
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YLR312C 3.91
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YER162C 3.83
RAD4
Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
YDR540C 3.81
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YHR125W 3.81 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL081W 3.77
IRA2
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin
YIR017C 3.76
MET28
Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
YJL037W 3.73
IRC18
Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
YGR032W 3.71
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YEL012W 3.71
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YIL166C 3.65 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YLR311C 3.64 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL017C 3.62
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YLL062C 3.61
MHT1
S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YLR092W 3.58
SUL2
High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YIL057C 3.57 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YJL042W 3.55
MHP1
Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
YPR160W 3.41
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YLR307C-A 3.34 Putative protein of unknown function
YBL015W 3.30
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YAR047C 3.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR342C 3.26
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YPL230W 3.24
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YFR053C 3.18
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YJR138W 3.14
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YML091C 3.14
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YER076W-A 3.11 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YER076C 3.07 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YGR256W 3.04
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YDL149W 3.02
ATG9
Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes; forms a complex with Atg23p and Atg27p
YLR267W 2.99
BOP2
Protein of unknown function, overproduction suppresses a pam1 slv3 double null mutation
YDR406W 2.98
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YLR247C 2.95
IRC20
Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YBL064C 2.95
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YNL133C 2.88
FYV6
Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YOR192C 2.80
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YOR011W-A 2.79 Putative protein of unknown function
YHL046W-A 2.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR192C-C 2.75 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YJR147W 2.74
HMS2
Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
YOR178C 2.73
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YOR100C 2.69
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YPR184W 2.69
GDB1
Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria
YHR176W 2.68
FMO1
Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins
YNR047W 2.66 Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate
YER101C 2.65
AST2
Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions
YJR137C 2.64
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YGR191W 2.62
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YER065C 2.57
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YIR018W 2.54
YAP5
Basic leucine zipper (bZIP) transcription factor
YIL099W 2.54
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
YBR056W-A 2.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YHR052W-A 2.51 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1
YBR292C 2.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YHL047C 2.48
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YDL215C 2.46
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YPL018W 2.45
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YDR387C 2.44 Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
YER085C 2.44 Putative protein of unknown function
YOL082W 2.42
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YHL037C 2.42 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL100W 2.41
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YNL322C 2.41
KRE1
Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
YGL255W 2.38
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YJL038C 2.37
LOH1
Putative protein of unknown function; expression induced during sporulation and repressed during vegetative growth by Sum1p and Hst1p; similar to adjacent open reading frame, YJL037W
YML131W 2.36 Putative protein of unknown function with similarity to oxidoreductases; HOG1 and SKO1-dependent mRNA expression is induced after osmotic shock; GFP-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS
YGL256W 2.33
ADH4
Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YDL010W 2.32
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YEL028W 2.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER091C-A 2.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YFL030W 2.29
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YGL045W 2.28
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YHR202W 2.28 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YAL066W 2.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR316C-B 2.26 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL049W 2.24
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YDL011C 2.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YGL258W-A 2.22 Putative protein of unknown function
YOR177C 2.18
MPC54
Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate
YPL111W 2.15
CAR1
Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance
YGR190C 2.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YMR317W 2.13 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YKL177W 2.07 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YKL163W 2.05
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YGL183C 2.04
MND1
Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks
YFR030W 2.03
MET10
Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
YDR173C 2.03
ARG82
Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes
YKR103W 2.01
NFT1
Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds.
YBR013C 2.01 Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein
YMR297W 2.00
PRC1
Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YDR259C 2.00
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YPL033C 1.99 Putative protein of unknown function; may be involved in DNA metabolism; expression is induced by Kar4p
YLR307W 1.97
CDA1
Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall
YKL188C 1.96
PXA2
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YOL106W 1.96 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YIL055C 1.95 Putative protein of unknown function
YOR023C 1.94
AHC1
Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
YNL117W 1.92
MLS1
Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium
YIL101C 1.90
XBP1
Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate
YDL244W 1.88
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YER150W 1.85
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YGR260W 1.84
TNA1
High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)
YPR028W 1.82
YOP1
Membrane protein that interacts with Yip1p to mediate membrane traffic; overexpression results in cell death and accumulation of internal cell membranes; regulates vesicular traffic in stressed cells
YLR152C 1.81 Putative protein of unknown function; YLR152C is not an essential gene
YOL084W 1.80
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YGL096W 1.79
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YIL046W 1.77
MET30
F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
YDR536W 1.77
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YDR343C 1.74
HXT6
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3
YOR384W 1.71
FRE5
Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR298C 1.69
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YLL057C 1.69
JLP1
Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
YKL093W 1.65
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YOR190W 1.65
SPR1
Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance
YHR006W 1.64
STP2
Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes
YDL012C 1.63 Plasma membrane protein of unknown function; YDL012C is not an essential gene
YKR040C 1.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
YER069W 1.62
ARG5,6
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YER084W 1.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR254W 1.60
CHL4
Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p
YIL014C-A 1.59 Putative protein of unknown function
YDR042C 1.59 Putative protein of unknown function; expression is increased in ssu72-ts69 mutant
YBR285W 1.57 Putative protein of unknown function; YBR285W is not an essential gene and deletion of YBR285W leads to poor growth on glucose-minimal medium at 15C
YKL044W 1.57 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YKL178C 1.57
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YHR097C 1.56 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YMR206W 1.54 Putative protein of unknown function; YMR206W is not an essential gene
YPR054W 1.53
SMK1
Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
YBR105C 1.52
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YJL161W 1.51
FMP33
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER068C-A 1.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR281C 1.50
PHM6
Protein of unknown function, expression is regulated by phosphate levels
YDR096W 1.50
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YPL165C 1.49
SET6
Protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability
YLR228C 1.44
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YHR146W 1.44
CRP1
Protein that binds to cruciform DNA structures
YOL052C 1.44
SPE2
S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
YGL015C 1.44 Hypothetical protein
YBR019C 1.43
GAL10
UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers
YOL047C 1.43 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGR087C 1.42
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YKL032C 1.42
IXR1
Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YPL135W 1.42
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YOR020W-A 1.41 Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL102C-A 1.40 Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species

Network of associatons between targets according to the STRING database.

First level regulatory network of MET32

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 9.8 GO:0015847 putrescine transport(GO:0015847)
2.0 7.9 GO:0006527 arginine catabolic process(GO:0006527)
1.9 7.5 GO:0006848 pyruvate transport(GO:0006848)
1.7 5.2 GO:0000101 sulfur amino acid transport(GO:0000101)
1.6 8.2 GO:0005980 glycogen catabolic process(GO:0005980)
1.6 8.0 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
1.5 4.6 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
1.5 12.1 GO:0015891 siderophore transport(GO:0015891)
1.4 11.3 GO:0005987 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
1.4 5.5 GO:0072337 modified amino acid transport(GO:0072337)
1.4 4.1 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
1.3 4.0 GO:0008272 sulfate transport(GO:0008272)
1.3 3.8 GO:1900371 regulation of cyclic nucleotide metabolic process(GO:0030799) regulation of cyclic nucleotide biosynthetic process(GO:0030802) regulation of nucleotide biosynthetic process(GO:0030808) regulation of cAMP metabolic process(GO:0030814) regulation of cAMP biosynthetic process(GO:0030817) regulation of purine nucleotide biosynthetic process(GO:1900371)
1.2 3.5 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
1.1 3.4 GO:0015888 thiamine transport(GO:0015888)
1.0 9.3 GO:0006097 glyoxylate cycle(GO:0006097)
1.0 2.0 GO:0000821 regulation of arginine metabolic process(GO:0000821)
1.0 3.0 GO:0006538 glutamate catabolic process(GO:0006538)
1.0 25.7 GO:0098656 anion transmembrane transport(GO:0098656)
0.9 3.7 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.9 3.7 GO:0071467 cellular response to pH(GO:0071467)
0.8 20.0 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.8 2.4 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.8 2.3 GO:0006545 glycine biosynthetic process(GO:0006545)
0.8 2.3 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.7 0.7 GO:0006824 cobalt ion transport(GO:0006824)
0.7 1.4 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.7 3.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.7 2.0 GO:0019748 secondary metabolic process(GO:0019748)
0.7 4.0 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.6 4.4 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.6 7.3 GO:0046686 response to cadmium ion(GO:0046686)
0.6 3.0 GO:0061416 regulation of transcription from RNA polymerase II promoter in response to salt stress(GO:0061416)
0.6 1.8 GO:0015755 fructose transport(GO:0015755)
0.6 5.2 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.6 3.4 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.5 1.6 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.5 1.6 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.5 1.6 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.5 1.4 GO:0008216 spermidine metabolic process(GO:0008216)
0.5 3.3 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.5 5.1 GO:0071265 L-methionine biosynthetic process(GO:0071265)
0.5 7.5 GO:0006754 ATP biosynthetic process(GO:0006754)
0.5 3.2 GO:0006083 acetate metabolic process(GO:0006083)
0.5 2.3 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.5 0.5 GO:0046487 glyoxylate metabolic process(GO:0046487)
0.4 2.2 GO:0050810 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.4 1.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 0.4 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.4 0.4 GO:0061410 ethanol catabolic process(GO:0006068) primary alcohol catabolic process(GO:0034310) positive regulation of transcription from RNA polymerase II promoter in response to ethanol(GO:0061410) cellular response to ethanol(GO:0071361) cellular response to alcohol(GO:0097306)
0.4 3.0 GO:0006007 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.4 2.1 GO:1901072 polysaccharide catabolic process(GO:0000272) aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.4 1.3 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.4 1.6 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.4 3.2 GO:0006829 zinc II ion transport(GO:0006829)
0.4 2.4 GO:0015802 basic amino acid transport(GO:0015802)
0.4 11.9 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.4 0.4 GO:0009409 response to cold(GO:0009409) cellular response to cold(GO:0070417)
0.4 1.1 GO:0090630 activation of GTPase activity(GO:0090630)
0.4 1.5 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.4 3.6 GO:0045144 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.4 1.1 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.4 1.8 GO:0015793 glycerol transport(GO:0015793)
0.3 1.0 GO:0071456 cellular response to hypoxia(GO:0071456)
0.3 1.3 GO:0015886 heme transport(GO:0015886)
0.3 1.0 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.3 1.8 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.3 0.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 5.4 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.2 0.7 GO:0019320 hexose catabolic process(GO:0019320)
0.2 0.7 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.2 1.2 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.2 1.4 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256)
0.2 3.2 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 0.9 GO:0019563 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.2 3.4 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.2 1.9 GO:0045332 phospholipid translocation(GO:0045332)
0.2 0.6 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.2 1.0 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 1.8 GO:0051181 cofactor transport(GO:0051181)
0.2 1.6 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.2 0.4 GO:0071241 cellular response to inorganic substance(GO:0071241)
0.2 0.8 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.2 2.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.2 0.7 GO:0051099 positive regulation of binding(GO:0051099)
0.2 2.2 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.2 1.4 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.2 0.5 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.2 1.6 GO:0000755 cytogamy(GO:0000755)
0.2 0.8 GO:0006078 (1->6)-beta-D-glucan biosynthetic process(GO:0006078)
0.2 0.5 GO:0071825 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.2 0.7 GO:0006546 glycine catabolic process(GO:0006546)
0.2 1.1 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.2 1.6 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 0.5 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.2 0.5 GO:0006089 lactate metabolic process(GO:0006089)
0.1 1.8 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 3.8 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.4 GO:0032006 regulation of TOR signaling(GO:0032006)
0.1 1.0 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 2.3 GO:0001101 response to acid chemical(GO:0001101)
0.1 2.7 GO:0010324 membrane invagination(GO:0010324) lysosomal microautophagy(GO:0016237) single-organism membrane invagination(GO:1902534)
0.1 0.4 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.1 1.4 GO:0044088 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 1.5 GO:0006813 potassium ion transport(GO:0006813)
0.1 4.9 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 0.4 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 0.4 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.5 GO:0000435 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.1 1.8 GO:0048278 vesicle docking(GO:0048278)
0.1 2.5 GO:0031503 protein complex localization(GO:0031503)
0.1 4.2 GO:0022900 electron transport chain(GO:0022900)
0.1 0.6 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627) mitochondrial protein processing(GO:0034982)
0.1 0.2 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 1.0 GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress(GO:0061408)
0.1 0.6 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.4 GO:0032108 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 4.3 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.1 GO:0009593 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.1 4.7 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.1 GO:0007533 mating type switching(GO:0007533)
0.1 0.4 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.1 GO:0045740 positive regulation of DNA replication(GO:0045740)
0.1 0.2 GO:0090155 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 0.7 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 8.0 GO:0006457 protein folding(GO:0006457)
0.1 1.1 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 1.2 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.1 0.2 GO:2001038 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 0.8 GO:0000011 vacuole inheritance(GO:0000011)
0.1 0.7 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.1 0.3 GO:0032979 protein insertion into membrane from inner side(GO:0032978) protein insertion into mitochondrial membrane from inner side(GO:0032979) protein insertion into mitochondrial membrane(GO:0051204)
0.1 0.2 GO:0018105 carbon utilization(GO:0015976) peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.1 0.3 GO:0051352 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.1 0.7 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.3 GO:0043954 cellular component maintenance(GO:0043954)
0.1 0.4 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.6 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.4 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 3.9 GO:0016049 cell growth(GO:0016049)
0.1 0.3 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.1 0.4 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 0.8 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.1 0.2 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.4 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 0.6 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.1 0.7 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.7 GO:0006611 protein export from nucleus(GO:0006611)
0.1 0.3 GO:0009231 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.1 0.7 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 1.0 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0032371 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.0 1.0 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.4 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.2 GO:0046464 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.0 0.5 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.7 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.3 GO:0030242 pexophagy(GO:0030242)
0.0 0.0 GO:0051098 regulation of binding(GO:0051098)
0.0 0.4 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.3 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0071451 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) detoxification(GO:0098754) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.4 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.3 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.1 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.0 0.1 GO:0046688 response to copper ion(GO:0046688)
0.0 0.1 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.2 GO:0000132 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.0 0.0 GO:0045981 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.0 0.2 GO:0006865 amino acid transport(GO:0006865)
0.0 0.6 GO:0006869 lipid transport(GO:0006869)
0.0 0.2 GO:0042766 nucleosome mobilization(GO:0042766)
0.0 0.1 GO:0009098 leucine biosynthetic process(GO:0009098)
0.0 0.2 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 0.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0043633 polyadenylation-dependent RNA catabolic process(GO:0043633)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 9.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
1.3 3.8 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
1.1 7.8 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
1.0 8.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.9 3.8 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.9 3.7 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.9 2.7 GO:0045265 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.8 4.1 GO:0034448 EGO complex(GO:0034448)
0.8 3.1 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.6 2.5 GO:0000817 COMA complex(GO:0000817)
0.6 1.8 GO:0005796 Golgi lumen(GO:0005796)
0.6 1.7 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.5 1.4 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.5 1.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.4 0.8 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 3.0 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.3 1.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.3 4.0 GO:0005619 ascospore wall(GO:0005619)
0.3 3.1 GO:0030677 ribonuclease P complex(GO:0030677)
0.3 0.9 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.3 0.9 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.3 1.9 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 5.0 GO:0070847 core mediator complex(GO:0070847)
0.2 2.9 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 15.3 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 1.5 GO:0034657 GID complex(GO:0034657)
0.2 1.9 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.2 0.6 GO:0016363 nuclear matrix(GO:0016363)
0.2 1.2 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.2 0.4 GO:0032389 MutLalpha complex(GO:0032389)
0.2 0.6 GO:0009277 fungal-type cell wall(GO:0009277)
0.2 0.7 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.6 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.3 GO:0000795 synaptonemal complex(GO:0000795)
0.1 2.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 2.3 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 0.8 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.9 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.8 GO:0033698 Rpd3L complex(GO:0033698)
0.1 1.4 GO:0000942 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 17.6 GO:0000322 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.1 2.0 GO:0005628 prospore membrane(GO:0005628) intracellular immature spore(GO:0042763) ascospore-type prospore(GO:0042764)
0.1 0.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.4 GO:0033309 SBF transcription complex(GO:0033309)
0.1 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.1 0.4 GO:0030139 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 0.3 GO:0070274 RES complex(GO:0070274)
0.1 0.2 GO:0070211 Snt2C complex(GO:0070211)
0.1 31.7 GO:0005886 plasma membrane(GO:0005886)
0.1 0.9 GO:0000124 SAGA complex(GO:0000124)
0.1 4.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 2.5 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.9 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 2.7 GO:0005576 extracellular region(GO:0005576)
0.0 0.6 GO:0005682 U5 snRNP(GO:0005682)
0.0 2.8 GO:0043332 mating projection tip(GO:0043332)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.7 GO:0097346 INO80-type complex(GO:0097346)
0.0 0.0 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 1.0 GO:0005874 microtubule(GO:0005874)
0.0 3.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.1 GO:0000799 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.0 0.2 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.4 GO:0030120 vesicle coat(GO:0030120)
0.0 0.0 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.0 0.1 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 19.3 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
3.6 17.9 GO:0015295 solute:proton symporter activity(GO:0015295)
3.6 10.7 GO:0004564 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
2.3 6.9 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
1.6 4.8 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
1.5 4.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.4 6.9 GO:0015294 solute:cation symporter activity(GO:0015294)
1.4 5.4 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
1.3 4.0 GO:0015116 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
1.2 3.7 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
1.1 8.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
1.1 4.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
1.1 3.3 GO:0016289 CoA hydrolase activity(GO:0016289)
1.0 4.0 GO:0005537 mannose binding(GO:0005537)
0.9 2.7 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.9 2.6 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.9 8.6 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.9 4.3 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.8 3.3 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.8 5.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.7 2.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.6 9.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.6 3.2 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.6 2.5 GO:0042927 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.6 2.4 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.6 2.3 GO:0008198 ferrous iron binding(GO:0008198)
0.6 2.2 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.6 1.7 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.5 2.1 GO:0015386 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.5 2.0 GO:0004180 carboxypeptidase activity(GO:0004180)
0.5 5.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 3.4 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.5 1.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 1.8 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.4 3.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 4.7 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.4 0.7 GO:0005536 glucose binding(GO:0005536)
0.4 3.0 GO:0031072 heat shock protein binding(GO:0031072)
0.4 2.6 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.4 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.4 1.4 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.3 1.0 GO:0000150 recombinase activity(GO:0000150)
0.3 2.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 3.1 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 2.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.3 1.4 GO:0030246 carbohydrate binding(GO:0030246)
0.3 5.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.1 GO:0004396 hexokinase activity(GO:0004396)
0.2 1.9 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 4.4 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.2 5.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 1.6 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.2 0.7 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 1.3 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.2 1.1 GO:0017022 myosin binding(GO:0017022)
0.2 0.6 GO:0016504 peptidase activator activity(GO:0016504)
0.2 1.0 GO:0016783 sulfurtransferase activity(GO:0016783)
0.2 1.8 GO:0051184 cofactor transporter activity(GO:0051184)
0.2 2.3 GO:0022838 substrate-specific channel activity(GO:0022838)
0.2 4.0 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.2 0.6 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 0.7 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.2 8.8 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.2 0.9 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.2 0.8 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.2 0.7 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 2.0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.2 1.5 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.2 0.6 GO:0003916 DNA topoisomerase activity(GO:0003916)
0.2 0.5 GO:0061134 peptidase regulator activity(GO:0061134)
0.2 0.3 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.2 1.6 GO:0045182 translation regulator activity(GO:0045182)
0.2 0.5 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458)
0.1 3.8 GO:0003684 damaged DNA binding(GO:0003684)
0.1 5.8 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 8.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 6.5 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.1 0.7 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.1 2.1 GO:0050661 NADP binding(GO:0050661)
0.1 1.7 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.1 0.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.4 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 1.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.5 GO:0015211 purine nucleoside transmembrane transporter activity(GO:0015211)
0.1 0.4 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.3 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 0.5 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.3 GO:0004100 chitin synthase activity(GO:0004100)
0.1 0.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 6.2 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.7 GO:0043130 ubiquitin binding(GO:0043130)
0.1 1.1 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.4 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 1.9 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 1.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.6 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.1 0.7 GO:0008236 serine-type peptidase activity(GO:0008236)
0.1 1.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.4 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.2 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.4 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.6 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 0.1 GO:0016722 oxidoreductase activity, oxidizing metal ions(GO:0016722)
0.0 0.0 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.3 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.1 GO:0032183 SUMO binding(GO:0032183)
0.0 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.5 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.1 GO:0043492 ATPase activity, coupled to movement of substances(GO:0043492)
0.0 0.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.1 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9 2.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.6 1.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.6 1.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 1.4 PID NOTCH PATHWAY Notch signaling pathway
0.5 1.4 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 0.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.4 PID P73PATHWAY p73 transcription factor network
0.1 1.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 0.5 PID PLK1 PATHWAY PLK1 signaling events
0.1 128.2 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
1.1 6.4 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.7 1.4 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.3 1.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 1.6 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 2.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 0.6 REACTOME MEIOSIS Genes involved in Meiosis
0.1 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 0.7 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 127.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 0.3 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 0.7 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.1 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.0 0.1 REACTOME HEMOSTASIS Genes involved in Hemostasis