Results for MET32
Z-value: 1.60
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Transcription factors associated with MET32
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MET32
|
S000002661 | Zinc-finger DNA-binding transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YPL250C Show fit | 12.20 |
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate |
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| YIL162W Show fit | 10.69 |
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively |
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| YLR327C Show fit | 10.41 |
Protein of unknown function that associates with ribosomes |
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| YNL014W Show fit | 9.57 |
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells |
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| YBR072W Show fit | 9.50 |
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells |
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| YPL054W Show fit | 9.37 |
Zinc-finger protein of unknown function |
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| YGL184C Show fit | 9.34 |
Cystathionine beta-lyase, converts cystathionine into homocysteine |
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| YAR053W Show fit | 8.87 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
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| YLL056C Show fit | 8.70 |
Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene |
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| YDL210W Show fit | 8.68 |
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane |
Network of associatons between targets according to the STRING database.
First level regulatory network of MET32
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 25.7 | GO:0098656 | anion transmembrane transport(GO:0098656) |
| 0.8 | 20.0 | GO:0000422 | mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726) |
| 1.5 | 12.1 | GO:0015891 | siderophore transport(GO:0015891) |
| 0.4 | 11.9 | GO:0006200 | obsolete ATP catabolic process(GO:0006200) |
| 1.4 | 11.3 | GO:0005987 | sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987) |
| 2.5 | 9.8 | GO:0015847 | putrescine transport(GO:0015847) |
| 1.0 | 9.3 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 1.6 | 8.2 | GO:0005980 | glycogen catabolic process(GO:0005980) |
| 1.6 | 8.0 | GO:0033683 | nucleotide-excision repair, DNA incision(GO:0033683) |
| 0.1 | 8.0 | GO:0006457 | protein folding(GO:0006457) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.7 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.1 | 17.6 | GO:0000322 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 0.2 | 15.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 1.6 | 9.8 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 1.0 | 8.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 1.1 | 7.8 | GO:0000112 | nucleotide-excision repair factor 3 complex(GO:0000112) |
| 0.2 | 5.0 | GO:0070847 | core mediator complex(GO:0070847) |
| 0.8 | 4.1 | GO:0034448 | EGO complex(GO:0034448) |
| 0.3 | 4.0 | GO:0005619 | ascospore wall(GO:0005619) |
| 0.1 | 4.0 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 19.3 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 3.6 | 17.9 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 3.6 | 10.7 | GO:0004564 | beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575) |
| 0.6 | 9.6 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.2 | 8.8 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.9 | 8.6 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 0.1 | 8.6 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 1.1 | 8.0 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 2.3 | 6.9 | GO:0008137 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.4 | 6.9 | GO:0015294 | solute:cation symporter activity(GO:0015294) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 128.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 2.0 | 5.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.9 | 2.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.6 | 1.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.6 | 1.8 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.5 | 1.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.5 | 1.4 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.1 | 1.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.2 | 0.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 0.5 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 127.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.1 | 6.4 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |
| 1.1 | 4.3 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.2 | 2.0 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 1.6 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.7 | 1.4 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.3 | 1.4 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.7 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 0.7 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.2 | 0.6 | REACTOME MEIOSIS | Genes involved in Meiosis |