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Results for MET31

Z-value: 0.83

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Transcription factors associated with MET31

Gene Symbol Gene ID Gene Info
MET31
S000005959 Zinc-finger DNA-binding transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MET31YPL038W-0.183.7e-01Click!

Activity profile of MET31 motif

Sorted Z-values of MET31 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YPL250C 6.13
ICY2
Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate
YPL223C 5.53
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YDL210W 5.35
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YGL184C 4.98
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YLR327C 4.75
TMA10
Protein of unknown function that associates with ribosomes
YJL116C 3.91
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YAR053W 3.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL054W 3.45
LEE1
Zinc-finger protein of unknown function
YML089C 3.39 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YFR053C 3.24
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YLL056C 3.18 Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in pleiotropic drug resistance (PDR) phenomenon; YLL056C is not an essential gene
YAR060C 3.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL036W 3.07
MUP3
Low affinity methionine permease, similar to Mup1p
YAL062W 2.87
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YKL217W 2.81
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YFL052W 2.75 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YHR212C 2.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR383C 2.57
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YIL162W 2.54
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YHR212W-A 2.52 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YLL055W 2.36
YCT1
High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene
YLR122C 2.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YCR005C 2.26
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YML090W 2.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source
YMR081C 2.15
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YLL061W 2.14
MMP1
High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p
YBR072W 2.14
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YBR292C 2.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YGR032W 2.06
GSC2
Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
YPL222W 2.05
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR259C 2.04
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YML081C-A 2.04
ATP18
Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms
YJR095W 2.00
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YOR393W 1.98
ERR1
Protein of unknown function, has similarity to enolases
YML091C 1.98
RPM2
Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YFL055W 1.95
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YLR123C 1.93 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YLR124W 1.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGR087C 1.85
PDC6
Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation
YJL199C 1.84
MBB1
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies
YKR034W 1.81
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YHR145C 1.81 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIR017C 1.78
MET28
Transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism
YOR378W 1.68 Putative protein of unknown function; belongs to the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene
YEL059W 1.68 Dubious open reading frame unlikely to encode a functional protein
YAL067C 1.63
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YBR117C 1.62
TKL2
Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids
YKL065W-A 1.62 Putative protein of unknown function
YBR056W-A 1.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B
YKL026C 1.59
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YBR077C 1.57
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YLL062C 1.54
MHT1
S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio
YDR043C 1.53
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YGR256W 1.53
GND2
6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone
YER091C-A 1.52 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHL046W-A 1.51 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLL060C 1.51
GTT2
Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p
YHL037C 1.50 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR100C 1.49
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YKR102W 1.48
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YOL082W 1.46
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YOR152C 1.45 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YFL030W 1.44
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YER084W 1.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR007C 1.41 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YGL180W 1.40
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YPR002W 1.40
PDH1
Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
YJR138W 1.40
IML1
Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane
YHL024W 1.38
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YKL163W 1.38
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YFR023W 1.36
PES4
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YBR045C 1.36
GIP1
Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
YER103W 1.36
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YNR063W 1.34 Putative zinc-cluster protein of unknown function
YLR092W 1.33
SUL2
High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
YNL125C 1.33
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YOR023C 1.31
AHC1
Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex
YJR137C 1.30
ECM17
Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
YDR342C 1.29
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YLR125W 1.29 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YHL047C 1.29
ARN2
Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C
YJR154W 1.27 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YOR391C 1.25
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YLR312C 1.25
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YFL051C 1.24 Putative protein of unknown function; YFL051C is not an essential gene
YHR096C 1.22
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YOR024W 1.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR206W 1.20 Putative protein of unknown function; YMR206W is not an essential gene
YLR247C 1.20
IRC20
Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YMR040W 1.18
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YLR366W 1.17 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YDR528W 1.16
HLR1
Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A
YKL177W 1.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YIL166C 1.13 Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene
YLR259C 1.12
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YJR078W 1.11
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YLR438W 1.10
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YBR013C 1.08 Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein
YBR284W 1.07 Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin
YDL222C 1.06
FMP45
Integral membrane protein localized to mitochondria (untagged protein) and eisosomes, immobile patches at the cortex associated with endocytosis; sporulation and sphingolipid content are altered in mutants; has homologs SUR7 and YNL194C
YPL017C 1.06
IRC15
Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family, required for accurate meiotic chromosome segregation; null mutant displays increased levels of spontaneous Rad52 foci
YAL063C 1.04
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YAL066W 1.04 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIR018W 1.04
YAP5
Basic leucine zipper (bZIP) transcription factor
YJL100W 1.03
LSB6
Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization
YDR096W 1.03
GIS1
JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1
YBR230C 1.03
OM14
Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron
YDL149W 1.01
ATG9
Transmembrane protein involved in formation of Cvt and autophagic vesicles; cycles between the pre-autophagosomal structure and other cytosolic punctate structures, not found in autophagosomes; forms a complex with Atg23p and Atg27p
YGL121C 1.01
GPG1
Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Grp1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p
YKL093W 1.00
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YDR216W 0.99
ADR1
Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization
YMR244W 0.98 Putative protein of unknown function
YLR437C-A 0.98 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W
YER158C 0.96 Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p
YNR073C 0.96 Putative mannitol dehydrogenase
YNR047W 0.96 Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate
YOR011W-A 0.94 Putative protein of unknown function
YGL163C 0.94
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YOL051W 0.93
GAL11
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors
YFR030W 0.91
MET10
Subunit alpha of assimilatory sulfite reductase, which is responsible for the conversion of sulfite into sulfide
YMR107W 0.90
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YOR003W 0.90
YSP3
Putative precursor to the subtilisin-like protease III
YML118W 0.89
NGL3
Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p
YHR125W 0.89 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL004W 0.89
ATP16
Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YIL102C 0.88 Putative protein of unknown function
YGR088W 0.87
CTT1
Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide
YPR077C 0.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1
YPL134C 0.85
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YMR194C-B 0.85 Putative protein of unknown function
YKL178C 0.85
STE3
Receptor for a factor receptor, transcribed in alpha cells and required for mating by alpha cells, couples to MAP kinase cascade to mediate pheromone response; ligand bound receptors are endocytosed and recycled to the plasma membrane; GPCR
YHL043W 0.85
ECM34
Putative protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins
YNL018C 0.84 Putative protein of unknown function
YHR126C 0.84 Putative protein of unknown function; transcription dependent upon Azf1p
YER076W-A 0.84 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YGR258C 0.83
RAD2
Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
YDL114W 0.82 Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene
YGR144W 0.81
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YER088C 0.81
DOT6
Protein of unknown function, involved in telomeric gene silencing and filamentation
YNR002C 0.81
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YAR050W 0.81
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YGR069W 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR178C 0.79
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YDR036C 0.79
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YPR023C 0.79
EAF3
Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition
YNL014W 0.79
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YER162C 0.79
RAD4
Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
YHR102W 0.79
KIC1
Protein kinase of the PAK/Ste20 kinase family, required for cell integrity possibly through regulating 1,6-beta-glucan levels in the wall; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body
YKR069W 0.78
MET1
S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis
YLL053C 0.77 Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
YER004W 0.77
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YGR070W 0.77
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YER069W 0.77
ARG5,6
Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p
YML042W 0.75
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YOL159C-A 0.75 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YBL064C 0.75
PRX1
Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress; phosphorylated
YAR047C 0.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNL276C 0.75 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W
YDR360W 0.74
OPI7
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.
YLR365W 0.74 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YML081W 0.74 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene
YBR241C 0.73 Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
YKR032W 0.73 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL230W 0.73
USV1
Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis
YBR296C 0.73
PHO89
Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p
YJL042W 0.73
MHP1
Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
YDR171W 0.72
HSP42
Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock
YCL025C 0.72
AGP1
Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)
YDR359C 0.72
EAF1
Component of the NuA4 histone acetyltransferase complex; required for initiation of pre-meiotic DNA replication, probably due to its requirement for significant expression of IME1
YDR374C 0.72 Putative protein of unknown function
YJL101C 0.71
GSH1
Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
YLL052C 0.71
AQY2
Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YER068C-A 0.71 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER076C 0.71 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YGL045W 0.70
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YOR290C 0.70
SNF2
Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
YMR017W 0.69
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YOR392W 0.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YPL171C 0.68
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YEL012W 0.67
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YBR179C 0.66
FZO1
Mitochondrial integral membrane protein involved in mitochondrial fusion and maintenance of the mitochondrial genome; contains N-terminal GTPase domain
YGR268C 0.66
HUA1
Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly
YDL010W 0.66
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YPL166W 0.66
ATG29
Protein specifically required for autophagy; may function in autophagosome formation at the pre-autophagosomal structure in collaboration with other autophagy proteins
YDL194W 0.65
SNF3
Plasma membrane glucose sensor that regulates glucose transport; has 12 predicted transmembrane segments; long cytoplasmic C-terminal tail is required for low glucose induction of hexose transporter genes HXT2 and HXT4
YMR118C 0.65 Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene
YDR401W 0.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR230W-A 0.65 Putative protein of unknown function
YMR189W 0.64
GCV2
P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
YOL097W-A 0.63 Putative protein of unknown function; identified by expression profiling and mass spectrometry
YDL246C 0.63
SOR2
Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in fructose or mannose metabolism
YLR311C 0.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLL039C 0.63
UBI4
Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats
YHR139C 0.63
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YDR306C 0.63 F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YIR039C 0.62
YPS6
Putative GPI-anchored aspartic protease
YGL258W-A 0.62 Putative protein of unknown function
YNL200C 0.62 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIL055C 0.61 Putative protein of unknown function
YIL099W 0.61
SGA1
Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation

Network of associatons between targets according to the STRING database.

First level regulatory network of MET31

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.3 GO:0015847 putrescine transport(GO:0015847)
1.2 3.6 GO:0015755 fructose transport(GO:0015755)
0.9 1.8 GO:0008272 sulfate transport(GO:0008272)
0.9 2.6 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.7 2.1 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.7 2.8 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.6 1.9 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.6 3.7 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.6 1.8 GO:0090295 nitrogen catabolite repression of transcription(GO:0090295)
0.6 2.3 GO:0006848 pyruvate transport(GO:0006848)
0.5 1.5 GO:0006545 glycine biosynthetic process(GO:0006545)
0.5 1.9 GO:0019346 transsulfuration(GO:0019346)
0.5 3.8 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.5 1.9 GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway(GO:0000949)
0.5 3.8 GO:0015891 siderophore transport(GO:0015891)
0.5 1.4 GO:0019629 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.4 1.3 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
0.4 2.2 GO:0072337 modified amino acid transport(GO:0072337)
0.4 1.3 GO:0031998 regulation of fatty acid beta-oxidation(GO:0031998) positive regulation of fatty acid beta-oxidation(GO:0032000) regulation of fatty acid oxidation(GO:0046320) positive regulation of fatty acid oxidation(GO:0046321)
0.4 9.8 GO:0061726 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.4 1.1 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.4 1.5 GO:0046688 response to copper ion(GO:0046688)
0.3 1.4 GO:0006527 arginine catabolic process(GO:0006527)
0.3 0.9 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.3 2.1 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 2.7 GO:0006097 glyoxylate cycle(GO:0006097)
0.3 7.7 GO:0098656 anion transmembrane transport(GO:0098656)
0.3 1.4 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.3 0.6 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.3 3.9 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 0.8 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.3 1.0 GO:0016577 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.3 0.8 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.3 0.8 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.2 1.7 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 0.7 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.2 1.0 GO:0006546 glycine catabolic process(GO:0006546)
0.2 0.7 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.2 0.7 GO:0090630 activation of GTPase activity(GO:0090630)
0.2 0.2 GO:0015688 iron chelate transport(GO:0015688)
0.2 1.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 0.5 GO:0000101 sulfur amino acid transport(GO:0000101)
0.2 1.1 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.2 1.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.2 0.9 GO:0019184 glutathione biosynthetic process(GO:0006750) nonribosomal peptide biosynthetic process(GO:0019184)
0.2 0.4 GO:0006013 mannose metabolic process(GO:0006013)
0.2 0.6 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.2 0.6 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 1.8 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 0.8 GO:0060195 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.2 0.6 GO:0001315 age-dependent response to reactive oxygen species(GO:0001315) protein unfolding(GO:0043335) cellular age-dependent response to reactive oxygen species(GO:0072353)
0.2 0.6 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.2 1.5 GO:0015758 glucose transport(GO:0015758)
0.2 0.4 GO:0045980 negative regulation of nucleotide metabolic process(GO:0045980)
0.2 0.9 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 0.5 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.2 1.3 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 1.6 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.2 0.8 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.1 0.6 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.1 0.4 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.1 0.4 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.4 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.1 0.7 GO:0000023 maltose metabolic process(GO:0000023)
0.1 0.4 GO:0042843 D-xylose catabolic process(GO:0042843)
0.1 0.4 GO:0015888 thiamine transport(GO:0015888)
0.1 0.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 1.2 GO:0046686 response to cadmium ion(GO:0046686)
0.1 0.5 GO:2000909 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 0.7 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.4 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.1 1.1 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.1 0.5 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.1 0.1 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.1 0.9 GO:0006083 acetate metabolic process(GO:0006083)
0.1 0.1 GO:0008615 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 1.0 GO:0045721 negative regulation of gluconeogenesis(GO:0045721)
0.1 0.4 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.5 GO:0042357 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.1 0.7 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.2 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.1 1.2 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.1 0.7 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.4 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.4 GO:0051303 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 0.2 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.2 GO:0043200 response to amino acid(GO:0043200)
0.1 1.3 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.1 0.8 GO:0000755 cytogamy(GO:0000755)
0.1 0.5 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.2 GO:2001038 cellular response to drug(GO:0035690) regulation of response to drug(GO:2001023) positive regulation of response to drug(GO:2001025) regulation of cellular response to drug(GO:2001038) positive regulation of cellular response to drug(GO:2001040)
0.1 0.8 GO:0000103 sulfate assimilation(GO:0000103)
0.1 0.2 GO:0045596 negative regulation of cell differentiation(GO:0045596) negative regulation of developmental process(GO:0051093)
0.1 1.0 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.6 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 0.4 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 1.2 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.1 1.0 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 1.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.2 GO:0090282 positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.1 0.6 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.4 GO:2000105 positive regulation of DNA-dependent DNA replication(GO:2000105)
0.1 0.2 GO:0046113 nucleobase catabolic process(GO:0046113)
0.1 0.2 GO:0005993 trehalose catabolic process(GO:0005993)
0.1 0.3 GO:0015793 glycerol transport(GO:0015793)
0.1 1.5 GO:0031503 protein complex localization(GO:0031503)
0.1 0.1 GO:0072366 regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.1 0.3 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.8 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 1.0 GO:0007118 budding cell apical bud growth(GO:0007118)
0.1 0.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 0.2 GO:0046466 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.1 0.1 GO:0009593 detection of chemical stimulus(GO:0009593) detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594) detection of stimulus(GO:0051606)
0.1 0.3 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.8 GO:0019740 nitrogen utilization(GO:0019740)
0.1 1.2 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 2.5 GO:0070590 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 0.3 GO:0000255 allantoin metabolic process(GO:0000255) allantoin catabolic process(GO:0000256) cellular amide catabolic process(GO:0043605)
0.1 0.5 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.2 GO:0034389 lipid particle organization(GO:0034389)
0.1 0.4 GO:0006638 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639) triglyceride metabolic process(GO:0006641)
0.1 0.2 GO:0001304 progressive alteration of chromatin involved in replicative cell aging(GO:0001304) negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.1 0.5 GO:0019722 calcium-mediated signaling(GO:0019722)
0.1 0.3 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.2 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.3 GO:0006452 translational frameshifting(GO:0006452)
0.1 0.2 GO:0044783 G1 DNA damage checkpoint(GO:0044783)
0.1 0.4 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.2 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.3 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 2.9 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.2 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.4 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.2 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.0 0.3 GO:0015851 nucleobase transport(GO:0015851)
0.0 0.6 GO:0042026 protein refolding(GO:0042026)
0.0 0.2 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.0 0.1 GO:0050000 telomere localization(GO:0034397) chromosome localization(GO:0050000)
0.0 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.2 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.0 0.8 GO:0043633 polyadenylation-dependent RNA catabolic process(GO:0043633)
0.0 0.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712) meiotic chromosome separation(GO:0051307)
0.0 0.2 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.2 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 0.5 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.2 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.0 0.4 GO:0051293 establishment of spindle localization(GO:0051293) spindle localization(GO:0051653)
0.0 0.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.2 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.1 GO:0050821 protein stabilization(GO:0050821)
0.0 0.1 GO:0071456 response to hypoxia(GO:0001666) cellular response to hypoxia(GO:0071456)
0.0 0.1 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.2 GO:0046033 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.2 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.0 0.2 GO:0000161 MAPK cascade involved in osmosensory signaling pathway(GO:0000161)
0.0 0.1 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.0 0.2 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.2 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.2 GO:0000349 generation of catalytic spliceosome for first transesterification step(GO:0000349)
0.0 0.1 GO:0046036 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.0 0.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.0 0.1 GO:0051180 vitamin transport(GO:0051180)
0.0 0.2 GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615) proton-transporting ATP synthase complex assembly(GO:0043461)
0.0 0.0 GO:0031111 negative regulation of microtubule polymerization or depolymerization(GO:0031111)
0.0 0.2 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.1 GO:0001881 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.3 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.0 GO:0071041 CUT catabolic process(GO:0071034) antisense RNA transcript catabolic process(GO:0071041) CUT metabolic process(GO:0071043)
0.0 0.2 GO:0045910 negative regulation of DNA recombination(GO:0045910)
0.0 0.2 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.2 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.1 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.1 GO:0009092 homoserine metabolic process(GO:0009092)
0.0 0.0 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.4 GO:0043248 proteasome assembly(GO:0043248)
0.0 0.4 GO:0070646 protein modification by small protein removal(GO:0070646)
0.0 0.2 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.0 0.0 GO:0001112 DNA-templated transcriptional open complex formation(GO:0001112) protein-DNA complex remodeling(GO:0001120) macromolecular complex remodeling(GO:0034367)
0.0 0.1 GO:0018209 peptidyl-serine phosphorylation(GO:0018105) peptidyl-serine modification(GO:0018209)
0.0 0.1 GO:0090527 actin filament reorganization involved in cell cycle(GO:0030037) actin filament reorganization(GO:0090527)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) regulation of cell cycle G1/S phase transition(GO:1902806) positive regulation of cell cycle G1/S phase transition(GO:1902808) regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 0.0 GO:0070542 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.0 0.4 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.1 GO:0061393 positive regulation of transcription from RNA polymerase II promoter in response to osmotic stress(GO:0061393)
0.0 0.0 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.0 0.5 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.2 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:2000220 regulation of pseudohyphal growth(GO:2000220)
0.0 0.1 GO:0060969 negative regulation of chromatin silencing(GO:0031936) positive regulation of gene expression, epigenetic(GO:0045815) negative regulation of gene silencing(GO:0060969)
0.0 0.1 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.0 0.0 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.0 GO:0070726 cell wall assembly(GO:0070726)
0.0 0.1 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0 0.0 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.1 GO:0051053 negative regulation of DNA metabolic process(GO:0051053)
0.0 0.0 GO:0006513 protein monoubiquitination(GO:0006513)
0.0 0.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.7 2.8 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.5 2.9 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.3 1.4 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.3 1.0 GO:0005756 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.3 2.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.3 2.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 1.3 GO:0034448 EGO complex(GO:0034448)
0.2 1.0 GO:0005960 glycine cleavage complex(GO:0005960)
0.2 0.7 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.2 0.5 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.2 1.5 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.2 2.0 GO:0030677 ribonuclease P complex(GO:0030677)
0.2 0.4 GO:0009353 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.2 0.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 0.6 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 1.3 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.2 0.5 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.2 0.8 GO:0032221 Rpd3S complex(GO:0032221)
0.2 2.0 GO:0005619 ascospore wall(GO:0005619)
0.1 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.9 GO:0034657 GID complex(GO:0034657)
0.1 8.5 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.2 GO:0098797 plasma membrane protein complex(GO:0098797)
0.1 0.6 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.3 GO:0032176 split septin rings(GO:0032176) cellular bud neck split septin rings(GO:0032177)
0.1 0.3 GO:0005825 half bridge of spindle pole body(GO:0005825)
0.1 0.3 GO:0070274 RES complex(GO:0070274)
0.1 0.2 GO:0070211 Snt2C complex(GO:0070211)
0.1 0.4 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 1.4 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 1.0 GO:0016514 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.4 GO:0070772 PAS complex(GO:0070772)
0.1 0.3 GO:0030669 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.1 0.3 GO:0016587 Isw1 complex(GO:0016587)
0.1 1.2 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.1 0.2 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.3 GO:0030287 cell wall-bounded periplasmic space(GO:0030287)
0.1 0.6 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 1.3 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 1.1 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.1 0.2 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.1 0.2 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.1 0.2 GO:0033309 SBF transcription complex(GO:0033309)
0.1 0.4 GO:0033101 cellular bud membrane(GO:0033101)
0.0 0.5 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.5 GO:0033698 Rpd3L complex(GO:0033698)
0.0 0.4 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.0 0.7 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.4 GO:0000812 Swr1 complex(GO:0000812)
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.2 GO:0044697 HICS complex(GO:0044697)
0.0 0.2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 3.9 GO:0000329 fungal-type vacuole membrane(GO:0000329) lytic vacuole membrane(GO:0098852)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.5 GO:0031201 SNARE complex(GO:0031201)
0.0 0.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940) condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.2 GO:0070069 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) cytochrome complex(GO:0070069)
0.0 0.1 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.0 GO:0035649 Nrd1 complex(GO:0035649)
0.0 12.8 GO:0005739 mitochondrion(GO:0005739)
0.0 0.1 GO:0000142 cellular bud neck contractile ring(GO:0000142)
0.0 0.0 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.0 GO:0000126 transcription factor TFIIIB complex(GO:0000126)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.1 5.7 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.9 2.8 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.9 3.7 GO:0005537 mannose binding(GO:0005537)
0.8 2.5 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.8 2.5 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.8 2.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.7 2.9 GO:0004396 hexokinase activity(GO:0004396)
0.7 2.9 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.7 2.9 GO:0015295 solute:proton symporter activity(GO:0015295)
0.7 2.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.6 1.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271) sulfate transmembrane transporter activity(GO:0015116)
0.5 1.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.5 1.9 GO:0004737 pyruvate decarboxylase activity(GO:0004737)
0.4 1.3 GO:0016289 CoA hydrolase activity(GO:0016289)
0.4 1.5 GO:0015343 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.4 1.5 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.4 0.7 GO:0005536 glucose binding(GO:0005536)
0.4 1.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.3 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 1.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.3 1.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 1.0 GO:0016642 glycine dehydrogenase (decarboxylating) activity(GO:0004375) oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor(GO:0016642)
0.3 0.9 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.3 3.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 0.8 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.3 0.8 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.3 1.0 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.3 2.5 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.3 0.8 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.2 1.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.2 1.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.3 GO:0015293 symporter activity(GO:0015293)
0.2 0.9 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.2 0.7 GO:0003954 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.2 0.4 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.2 0.9 GO:0008198 ferrous iron binding(GO:0008198)
0.2 0.4 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.2 0.6 GO:0016208 AMP binding(GO:0016208)
0.2 0.8 GO:0008169 C-methyltransferase activity(GO:0008169)
0.2 1.2 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 2.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 0.5 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.2 0.7 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.2 0.9 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.2 0.5 GO:0008902 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 2.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 1.0 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 1.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.4 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.1 0.4 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.1 0.1 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 1.1 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.4 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.1 0.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.1 0.7 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.1 1.0 GO:0016723 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 1.6 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 1.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 1.2 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.1 0.4 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.8 GO:0030246 carbohydrate binding(GO:0030246)
0.1 0.4 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.1 0.2 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.1 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 0.7 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.4 GO:0022821 potassium:proton antiporter activity(GO:0015386) potassium ion antiporter activity(GO:0022821)
0.1 2.2 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.1 GO:0019903 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.1 1.7 GO:0051087 chaperone binding(GO:0051087)
0.1 0.3 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.1 0.3 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.1 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.1 0.2 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1 2.2 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.3 GO:0005261 cation channel activity(GO:0005261)
0.1 0.2 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 0.1 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.1 0.3 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1 0.3 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782) sulfurtransferase activity(GO:0016783)
0.1 0.5 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.1 0.2 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 0.5 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 0.9 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 0.1 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 0.4 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662)
0.1 1.4 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 0.1 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.6 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.4 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0099600 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.0 0.2 GO:0017022 myosin binding(GO:0017022)
0.0 0.2 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.0 0.4 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.2 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.5 GO:0016769 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.2 GO:0050253 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.0 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) RNA polymerase III transcription factor binding(GO:0001025) TFIIIB-type transcription factor activity(GO:0001026) TFIIIC-class transcription factor binding(GO:0001156)
0.0 1.2 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.1 GO:0030983 mismatched DNA binding(GO:0030983)
0.0 2.0 GO:0003682 chromatin binding(GO:0003682)
0.0 0.1 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.3 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.0 0.2 GO:0001083 transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083)
0.0 0.3 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.2 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.4 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.0 0.3 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 1.1 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 0.1 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.0 0.1 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.0 0.2 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.1 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.0 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.1 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.0 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.6 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 1.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 1.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 0.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.2 PID NOTCH PATHWAY Notch signaling pathway
0.1 0.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.3 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 65.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.1 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.0 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.4 1.3 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.1 0.3 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 0.4 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 0.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 63.4 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.1 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 0.2 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.0 REACTOME SIGNALING BY ERBB2 Genes involved in Signaling by ERBB2
0.0 0.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.0 0.0 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins