Results for MAC1
Z-value: 0.82
Motif logo
Transcription factors associated with MAC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
MAC1
|
S000004623 | Copper-sensing transcription factor |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YJL089W Show fit | 3.76 |
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus |
||
| YPR124W Show fit | 3.40 |
High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels |
||
| YPR123C Show fit | 3.29 |
Hypothetical protein |
||
| YKL148C Show fit | 2.44 |
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone |
||
| YLR214W Show fit | 2.03 |
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels |
||
| YIL162W Show fit | 1.90 |
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively |
||
| YMR271C Show fit | 1.77 |
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5 |
||
| YKL147C Show fit | 1.76 |
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3 |
||
| YKR097W Show fit | 1.74 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
||
| YKL146W Show fit | 1.70 |
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters |
Network of associatons between targets according to the STRING database.
First level regulatory network of MAC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 6.3 | GO:0015677 | copper ion import(GO:0015677) |
| 1.3 | 3.8 | GO:0061414 | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414) |
| 0.6 | 3.1 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 0.3 | 2.6 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.0 | 2.5 | GO:0032543 | mitochondrial translation(GO:0032543) |
| 0.5 | 2.4 | GO:0034487 | amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746) |
| 0.2 | 2.4 | GO:0072593 | reactive oxygen species metabolic process(GO:0072593) |
| 0.1 | 2.3 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.2 | 2.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.5 | 2.0 | GO:0015847 | putrescine transport(GO:0015847) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.6 | 3.1 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.1 | 3.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 3.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.3 | 2.8 | GO:0042597 | periplasmic space(GO:0042597) |
| 0.0 | 2.8 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 2.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.8 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.8 | GO:0005576 | extracellular region(GO:0005576) |
| 0.2 | 1.4 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.8 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 1.1 | 3.2 | GO:0015088 | copper uptake transmembrane transporter activity(GO:0015088) |
| 0.6 | 3.1 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 0.1 | 3.1 | GO:0001228 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.3 | 2.7 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723) |
| 0.2 | 2.7 | GO:0010181 | FMN binding(GO:0010181) |
| 0.2 | 2.6 | GO:0016763 | transferase activity, transferring pentosyl groups(GO:0016763) |
| 0.0 | 2.5 | GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616) |
| 0.8 | 2.3 | GO:0004108 | citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440) |
| 0.7 | 2.1 | GO:0004575 | beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.8 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 1.1 | 3.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 1.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 0.8 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 0.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 0.4 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 0.1 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 0.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.7 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 3.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.4 | REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM | Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism |
| 0.3 | 1.0 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 0.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 0.8 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 0.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 0.4 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.1 | 0.2 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 0.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |