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Results for MAC1

Z-value: 0.82

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Transcription factors associated with MAC1

Gene Symbol Gene ID Gene Info
MAC1
S000004623 Copper-sensing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MAC1YMR021C0.039.0e-01Click!

Activity profile of MAC1 motif

Sorted Z-values of MAC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJL089W 3.76
SIP4
C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus
YPR124W 3.40
CTR1
High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels
YPR123C 3.29 Hypothetical protein
YKL148C 2.44
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YLR214W 2.03
FRE1
Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
YIL162W 1.90
SUC2
Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively
YMR271C 1.77
URA10
Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5
YKL147C 1.76 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
YKR097W 1.74
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YKL146W 1.70
AVT3
Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
YAR053W 1.65 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL060W 1.61
BDH1
NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
YPL092W 1.54
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YLR377C 1.53
FBP1
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism
YDR536W 1.37
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YDL210W 1.35
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YAR060C 1.31 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER065C 1.29
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YFR053C 1.28
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YCL001W-B 1.24 Putative protein of unknown function; identified by homology
YIL033C 1.20
BCY1
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YMR090W 1.16 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YCR005C 1.12
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YPR054W 1.09
SMK1
Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p
YDL182W 1.06
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YGL255W 1.05
ZRT1
High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor
YOR343C 1.02 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YGL256W 1.00
ADH4
Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency
YDR540C 1.00
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YOR100C 1.00
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YDR032C 0.98
PST2
Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YMR297W 0.98
PRC1
Vacuolar carboxypeptidase Y (proteinase C), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
YJR115W 0.94 Putative protein of unknown function
YLR213C 0.94
CRR1
Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
YMR107W 0.92
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR081C 0.92
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YDL180W 0.92 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YFL019C 0.91 Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene
YLR152C 0.91 Putative protein of unknown function; YLR152C is not an essential gene
YFR047C 0.90
BNA6
Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p
YBR069C 0.89
TAT1
Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance
YPR001W 0.89
CIT3
Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate
YFR017C 0.88 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YHR212C 0.86 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR327C 0.85
TMA10
Protein of unknown function that associates with ribosomes
YLR258W 0.82
GSY2
Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase
YGR191W 0.81
HIP1
High-affinity histidine permease, also involved in the transport of manganese ions
YPL229W 0.80 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene
YLR122C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YKL217W 0.80
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR152C 0.79 Putative protein of unknown function; has no similarity to any known protein; YOR152C is not an essential gene
YFL051C 0.77 Putative protein of unknown function; YFL051C is not an essential gene
YGR190C 0.77 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
YPR191W 0.75
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YPL274W 0.75
SAM3
High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p
YNL160W 0.74
YGP1
Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
YPL171C 0.73
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YER066W 0.73 Putative protein of unknown function; YER066W is not an essential gene
YNR014W 0.73 Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible
YNL194C 0.73 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YAR047C 0.72 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YMR319C 0.72
FET4
Low-affinity Fe(II) transporter of the plasma membrane
YCL005W 0.72
LDB16
Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
YLR123C 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YBR209W 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene
YFR007W 0.70
YFH7
Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YER076C 0.70 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization
YCL048W-A 0.70 Putative protein of unknown function
YJL062W-A 0.70 Putative protein of unknown function, identified based on comparison to related yeast species; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YFL024C 0.69
EPL1
Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb
YBR145W 0.69
ADH5
Alcohol dehydrogenase isoenzyme V; involved in ethanol production
YNL086W 0.69 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to endosomes
YPL135W 0.68
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YMR089C 0.68
YTA12
Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes
YAL061W 0.67
BDH2
Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; BDH2 is an essential gene
YCL038C 0.67
ATG22
Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
YPR196W 0.67 Putative maltose activator
YLR203C 0.67
MSS51
Nuclear encoded protein required for translation of COX1 mRNA; binds to Cox1 protein
YMR008C 0.67
PLB1
Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
YER039C-A 0.66 Putative protein of unknown function; YER039C-A is not an essential gene
YOR316C 0.66
COT1
Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium
YHR048W 0.66
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YLR279W 0.66 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL082W 0.63
ATG19
Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; recognizes cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) and delivers them to the preautophagosomal structure for packaging into Cvt vesicles
YNL046W 0.62 Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YLR295C 0.62
ATP14
Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YDR411C 0.62
DFM1
ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes
YIL113W 0.61
SDP1
Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
YOR049C 0.61
RSB1
Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
YNL134C 0.59 Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS
YLR259C 0.59
HSP60
Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated
YPL006W 0.59
NCR1
Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
YDR453C 0.59
TSA2
Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants
YGL104C 0.59
VPS73
Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family
YDR476C 0.58 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene
YMR013C 0.58
SEC59
Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
YGR174C 0.58
CBP4
Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p
YGL062W 0.58
PYC1
Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis
YAR050W 0.58
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YGL040C 0.58
HEM2
Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus
YBR035C 0.58
PDX3
Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism
YCL054W 0.57
SPB1
AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YDR178W 0.57
SDH4
Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YDR342C 0.57
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YOR192C 0.56
THI72
Transporter of thiamine or related compound; shares sequence similarity with Thi7p
YNL014W 0.56
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YNL200C 0.56 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBL015W 0.54
ACH1
Acetyl-coA hydrolase, primarily localized to mitochondria; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
YBR053C 0.54 Putative protein of unknown function; induced by cell wall perturbation
YIL060W 0.54 Putative protein of unknown function; mutant accumulates less glycogen than does wild type; YIL060W is not an essential gene
YHR211W 0.54
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YER038W-A 0.53
FMP49
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
YHR116W 0.53
COX23
Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p
YER076W-A 0.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C
YNL144C 0.53 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YOR120W 0.53
GCY1
Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family
YDR516C 0.53
EMI2
Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p
YOR002W 0.52
ALG6
Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
YIL087C 0.52
LRC2
Putative protein of unknown function; protein is detected in purified mitochondria in high-throughput studies; null mutant displays decreased mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YOL084W 0.51
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YPR093C 0.51
ASR1
Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain
YIL121W 0.51
QDR2
Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake
YBL016W 0.51
FUS3
Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation
YPR127W 0.51 Putative protein of unknown function; expression is activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
YPR013C 0.51 Putative zinc finger protein; YPR013C is not an essential gene
YDL183C 0.51 Putative protein of unknown function; YDL183C is not an essential gene
YGR106C 0.49
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YEL011W 0.48
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL093W 0.48
MBR1
Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants
YHR055C 0.48
CUP1-2
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YMR133W 0.48
REC114
Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division
YMR320W 0.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKR102W 0.47
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YOR065W 0.47
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YJR048W 0.47
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YGL143C 0.46
MRF1
Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability
YPL117C 0.46
IDI1
Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability
YBR140C 0.46
IRA1
GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase
YIL059C 0.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W
YGR239C 0.45
PEX21
Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p
YLR125W 0.45 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YLR004C 0.45
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YDR036C 0.45
EHD3
3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
YGL184C 0.45
STR3
Cystathionine beta-lyase, converts cystathionine into homocysteine
YCR021C 0.45
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YIL032C 0.45 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPR027C 0.44 Putative protein of unknown function
YEL024W 0.44
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YLR356W 0.43 Putative protein of unknown function with similarity to SCM4; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR356W is not an essential gene
YDL072C 0.43
YET3
Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein
YHR139C 0.43
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YBL102W 0.43
SFT2
Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5
YML123C 0.42
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YIL058W 0.42 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER053C 0.42
PIC2
Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
YOL085W-A 0.42 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YNR050C 0.41
LYS9
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YHR053C 0.41
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YLR030W 0.41 Putative protein of unknown function
YPL048W 0.41
CAM1
Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma
YKL038W 0.40
RGT1
Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor
YMR135C 0.40
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YOL154W 0.40
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YAR068W 0.40 Fungal-specific protein of unknown function; induced in respiratory-deficient cells
YJL172W 0.40
CPS1
Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions
YER133W-A 0.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C.
YHR202W 0.40 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization
YJL093C 0.39
TOK1
Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin
YOR149C 0.39
SMP3
Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure
YLR228C 0.39
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YLR374C 0.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
YBL049W 0.39
MOH1
Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for viability in stationary phase
YDR249C 0.38 Putative protein of unknown function
YJR095W 0.38
SFC1
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization
YHR054C 0.38 Putative protein of unknown function
YLR375W 0.38
STP3
Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids
YDR530C 0.38
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YNL052W 0.38
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YMR042W 0.37
ARG80
Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p
YGR022C 0.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YMR206W 0.37 Putative protein of unknown function; YMR206W is not an essential gene
YLR395C 0.37
COX8
Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YFL020C 0.37
PAU5
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YNL288W 0.37
CAF40
Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p
YNL179C 0.36 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YBR050C 0.36
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YDR298C 0.36
ATP5
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
YBL017C 0.36
PEP1
Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
YGR102C 0.36 Putative protein of unknown function; transposon insertion mutant is salt sensitive and deletion mutant has growth defects; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YGR110W 0.36 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YPL207W 0.35
TYW1
Protein required for the synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions
YNL180C 0.35
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YLR296W 0.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL060C 0.35
MAM3
Protein required for normal mitochondrial morphology, has similarity to hemolysins
YPR160W 0.34
GPH1
Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway
YGR149W 0.34 Putative protein of unknown function; predicted to be an integal membrane protein
YER033C 0.34
ZRG8
Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency
YBR220C 0.34 Putative protein of unknown function; YBR220C is not an essential gene
YJL217W 0.34 Cytoplasmic protein of unknown function; expression induced by calcium shortage and via the copper sensing transciption factor Mac1p during conditons of copper deficiency; mRNA is cell cycle regulated, peaking in G1 phase
YJL088W 0.34
ARG3
Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine

Network of associatons between targets according to the STRING database.

First level regulatory network of MAC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0061414 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061413) positive regulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source(GO:0061414)
0.8 6.3 GO:0015677 copper ion import(GO:0015677)
0.6 3.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.5 2.0 GO:0015847 putrescine transport(GO:0015847)
0.5 2.4 GO:0034487 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.4 1.3 GO:0015755 fructose transport(GO:0015755)
0.4 1.1 GO:0019626 propionate metabolic process(GO:0019541) propionate catabolic process(GO:0019543) short-chain fatty acid catabolic process(GO:0019626) propionate catabolic process, 2-methylcitrate cycle(GO:0019629)
0.4 1.1 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.3 1.3 GO:0019748 secondary metabolic process(GO:0019748)
0.3 2.6 GO:0006097 glyoxylate cycle(GO:0006097)
0.3 1.8 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) 'de novo' UMP biosynthetic process(GO:0044205)
0.3 1.5 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.3 1.4 GO:0015793 glycerol transport(GO:0015793)
0.3 0.8 GO:0015888 thiamine transport(GO:0015888)
0.3 1.1 GO:0006848 pyruvate transport(GO:0006848)
0.3 1.1 GO:0046688 response to copper ion(GO:0046688)
0.3 0.8 GO:0045117 azole transport(GO:0045117)
0.3 2.0 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.2 1.9 GO:0006829 zinc II ion transport(GO:0006829)
0.2 0.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.2 2.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 0.7 GO:0042843 D-xylose catabolic process(GO:0042843)
0.2 1.3 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.2 0.4 GO:0046323 glucose import(GO:0046323)
0.2 1.8 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.2 0.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 0.4 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.2 1.9 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.2 0.7 GO:0046352 disaccharide catabolic process(GO:0046352)
0.2 1.0 GO:0042407 cristae formation(GO:0042407)
0.2 1.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 0.5 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.2 2.4 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.1 0.6 GO:0032373 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.1 0.6 GO:1903137 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.1 0.8 GO:0051098 regulation of binding(GO:0051098)
0.1 0.4 GO:0034762 regulation of transmembrane transport(GO:0034762)
0.1 1.4 GO:0072348 sulfur compound transport(GO:0072348)
0.1 0.9 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.1 0.4 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 0.7 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.5 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.1 1.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.6 GO:0055069 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.1 0.6 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551)
0.1 1.7 GO:0046173 polyol biosynthetic process(GO:0046173)
0.1 0.3 GO:0006577 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
0.1 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.3 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.3 GO:0000821 regulation of arginine metabolic process(GO:0000821) regulation of cellular amine catabolic process(GO:0033241)
0.1 0.6 GO:0051292 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.8 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.1 0.4 GO:0055071 cellular manganese ion homeostasis(GO:0030026) manganese ion homeostasis(GO:0055071)
0.1 0.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.6 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.1 0.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.1 0.5 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.1 0.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.2 GO:0006103 2-oxoglutarate metabolic process(GO:0006103)
0.1 0.8 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.1 0.4 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 2.3 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.4 GO:0009209 CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036)
0.1 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.1 0.3 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.1 0.4 GO:0016114 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.1 0.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 0.3 GO:0019346 transsulfuration(GO:0019346)
0.1 0.2 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.1 0.3 GO:0097271 protein localization to bud neck(GO:0097271)
0.1 0.2 GO:1905038 regulation of sphingolipid biosynthetic process(GO:0090153) negative regulation of sphingolipid biosynthetic process(GO:0090155) regulation of membrane lipid metabolic process(GO:1905038)
0.1 1.3 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.1 0.9 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.1 0.5 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.1 0.5 GO:0006828 manganese ion transport(GO:0006828)
0.1 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 1.5 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 0.6 GO:0006084 acetyl-CoA metabolic process(GO:0006084)
0.1 0.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 0.8 GO:0051181 cofactor transport(GO:0051181)
0.1 0.5 GO:0015891 siderophore transport(GO:0015891)
0.1 0.3 GO:0032108 negative regulation of macroautophagy(GO:0016242) negative regulation of response to external stimulus(GO:0032102) negative regulation of response to extracellular stimulus(GO:0032105) negative regulation of response to nutrient levels(GO:0032108)
0.1 2.0 GO:0009060 aerobic respiration(GO:0009060)
0.1 1.2 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.1 0.3 GO:0000023 maltose metabolic process(GO:0000023)
0.1 0.6 GO:0006071 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.1 0.5 GO:0009306 protein secretion(GO:0009306)
0.1 1.0 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.2 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.2 GO:0006032 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.1 0.4 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.3 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.1 0.2 GO:0017006 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 0.2 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.2 GO:1903513 retrograde protein transport, ER to cytosol(GO:0030970) endoplasmic reticulum to cytosol transport(GO:1903513)
0.1 0.3 GO:0051260 protein homooligomerization(GO:0051260)
0.1 0.3 GO:0006074 (1->3)-beta-D-glucan metabolic process(GO:0006074)
0.1 0.3 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.1 0.1 GO:0050667 homocysteine metabolic process(GO:0050667)
0.1 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 0.1 GO:0015848 spermidine transport(GO:0015848)
0.1 0.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.0 0.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.2 GO:0015992 proton transport(GO:0015992)
0.0 0.1 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.0 1.1 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.4 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.1 GO:0006754 ATP biosynthetic process(GO:0006754)
0.0 0.2 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.0 0.2 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.0 0.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.3 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 1.5 GO:0070726 cell wall assembly(GO:0070726)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:2000001 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.3 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.0 0.5 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)
0.0 0.7 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0 0.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.0 0.3 GO:0045332 phospholipid translocation(GO:0045332)
0.0 0.7 GO:0016485 protein processing(GO:0016485)
0.0 0.1 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.2 GO:0003400 regulation of COPII vesicle coating(GO:0003400) regulation of vesicle targeting, to, from or within Golgi(GO:0048209) regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis(GO:0090113)
0.0 0.2 GO:0008299 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.0 0.2 GO:0018410 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.1 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.0 0.1 GO:0035268 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0006000 fructose metabolic process(GO:0006000)
0.0 0.1 GO:0031297 replication fork processing(GO:0031297)
0.0 0.4 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
0.0 0.1 GO:0006598 polyamine catabolic process(GO:0006598)
0.0 0.2 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 0.7 GO:0006505 GPI anchor metabolic process(GO:0006505)
0.0 0.1 GO:0032365 intracellular lipid transport(GO:0032365)
0.0 0.2 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.0 0.2 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 2.5 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.1 GO:0009187 cyclic nucleotide metabolic process(GO:0009187)
0.0 0.1 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends(GO:0000736)
0.0 0.5 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0015893 drug transport(GO:0015893)
0.0 0.1 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0055078 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.2 GO:0032447 protein urmylation(GO:0032447)
0.0 0.0 GO:0035384 thioester biosynthetic process(GO:0035384) acyl-CoA biosynthetic process(GO:0071616)
0.0 0.2 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.0 0.1 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.0 0.2 GO:0051453 regulation of cellular pH(GO:0030641) regulation of intracellular pH(GO:0051453)
0.0 0.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.0 0.1 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.0 0.1 GO:0006545 glycine biosynthetic process(GO:0006545) threonine catabolic process(GO:0006567)
0.0 0.1 GO:0051274 beta-glucan biosynthetic process(GO:0051274)
0.0 0.5 GO:0006312 mitotic recombination(GO:0006312)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0006661 phosphatidylinositol biosynthetic process(GO:0006661)
0.0 0.0 GO:0071629 cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629)
0.0 0.5 GO:0006839 mitochondrial transport(GO:0006839)
0.0 0.0 GO:0015976 carbon utilization(GO:0015976)
0.0 0.1 GO:0042026 protein refolding(GO:0042026)
0.0 0.0 GO:0010978 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.0 0.1 GO:0006874 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.0 0.0 GO:0009062 fatty acid catabolic process(GO:0009062)
0.0 0.0 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.0 GO:0036095 positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter(GO:0036095) positive regulation of invasive growth in response to glucose limitation(GO:2000219)
0.0 0.1 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.1 GO:0043112 receptor recycling(GO:0001881) protein import into peroxisome matrix, receptor recycling(GO:0016562) receptor metabolic process(GO:0043112)
0.0 0.0 GO:0034395 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to iron ion(GO:0071281)
0.0 0.0 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0009410 response to xenobiotic stimulus(GO:0009410)
0.0 0.1 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.0 0.2 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0 0.1 GO:0046834 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.0 GO:0065005 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.0 0.0 GO:1904668 positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.0 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.0 0.0 GO:1903727 positive regulation of phospholipid biosynthetic process(GO:0071073) positive regulation of phospholipid metabolic process(GO:1903727) positive regulation of phosphatidylcholine biosynthetic process(GO:2001247)
0.0 0.1 GO:0006771 riboflavin metabolic process(GO:0006771) riboflavin biosynthetic process(GO:0009231)
0.0 0.1 GO:0019217 regulation of fatty acid metabolic process(GO:0019217)
0.0 0.2 GO:0022900 electron transport chain(GO:0022900)
0.0 0.3 GO:0006200 obsolete ATP catabolic process(GO:0006200)
0.0 0.1 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.0 GO:0051444 negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.0 0.0 GO:0006390 transcription from mitochondrial promoter(GO:0006390)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.3 2.8 GO:0042597 periplasmic space(GO:0042597)
0.3 0.7 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.3 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.2 0.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.2 0.6 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.2 0.8 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277)
0.1 0.6 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.4 GO:0044284 mitochondrial crista junction(GO:0044284)
0.1 3.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 1.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1 1.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.7 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1 1.1 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.5 GO:0070469 respiratory chain(GO:0070469)
0.1 0.6 GO:0000837 Doa10p ubiquitin ligase complex(GO:0000837)
0.1 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.4 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.1 0.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.6 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.2 GO:0005775 vacuolar lumen(GO:0005775)
0.1 0.5 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.6 GO:0034657 GID complex(GO:0034657)
0.1 1.1 GO:0005619 ascospore wall(GO:0005619)
0.1 0.3 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.1 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.3 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177)
0.1 0.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 0.2 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.1 0.2 GO:0005784 Sec61 translocon complex(GO:0005784)
0.1 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.1 0.1 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.1 2.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.2 GO:0071819 DUBm complex(GO:0071819)
0.1 0.2 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.2 GO:0030428 cell septum(GO:0030428)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 1.8 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 2.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.6 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0034967 Set3 complex(GO:0034967)
0.0 0.2 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 1.3 GO:0032592 integral component of mitochondrial membrane(GO:0032592) intrinsic component of mitochondrial membrane(GO:0098573)
0.0 0.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.5 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0030139 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)
0.0 0.3 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 3.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.0 GO:0031160 spore wall(GO:0031160)
0.0 0.2 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 1.8 GO:0005576 extracellular region(GO:0005576)
0.0 0.9 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 20.8 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.1 GO:0044455 mitochondrial membrane part(GO:0044455)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.0 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.0 0.1 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.3 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.0 GO:0070823 HDA1 complex(GO:0070823)
0.0 0.1 GO:0000500 RNA polymerase I upstream activating factor complex(GO:0000500)
0.0 0.1 GO:0031201 SNARE complex(GO:0031201)
0.0 0.1 GO:0031932 TORC2 complex(GO:0031932)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.8 2.3 GO:0004108 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.8 3.8 GO:0015295 solute:proton symporter activity(GO:0015295)
0.7 2.1 GO:0004575 beta-fructofuranosidase activity(GO:0004564) sucrose alpha-glucosidase activity(GO:0004575)
0.6 3.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.6 1.7 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.5 1.0 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.5 1.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.4 1.8 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.6 GO:0005537 mannose binding(GO:0005537)
0.4 1.9 GO:0050308 sugar-phosphatase activity(GO:0050308)
0.4 0.7 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
0.3 1.0 GO:0016289 CoA hydrolase activity(GO:0016289)
0.3 1.4 GO:0004180 carboxypeptidase activity(GO:0004180)
0.3 0.9 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.3 2.7 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 1.4 GO:0004707 MAP kinase activity(GO:0004707)
0.2 2.7 GO:0010181 FMN binding(GO:0010181)
0.2 1.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 1.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 0.7 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.2 1.1 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) MAP kinase phosphatase activity(GO:0033549)
0.2 0.2 GO:0015248 sterol transporter activity(GO:0015248)
0.2 0.7 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.2 1.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 0.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 1.2 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.2 0.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 1.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.2 2.6 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.2 1.3 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.5 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.2 0.6 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.2 0.5 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.1 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 1.4 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.1 1.8 GO:0046527 glucosyltransferase activity(GO:0046527)
0.1 0.4 GO:0004629 phospholipase C activity(GO:0004629)
0.1 1.4 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.1 0.6 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.4 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.1 1.2 GO:0005216 ion channel activity(GO:0005216)
0.1 0.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.3 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
0.1 0.7 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 0.3 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.4 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 1.5 GO:0020037 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.1 0.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 0.3 GO:0008242 omega peptidase activity(GO:0008242)
0.1 0.6 GO:0015293 symporter activity(GO:0015293)
0.1 0.3 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.1 0.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 0.8 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.6 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.1 1.4 GO:0015297 antiporter activity(GO:0015297)
0.1 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.2 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 0.4 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.1 0.2 GO:0003951 NAD+ kinase activity(GO:0003951) NADH kinase activity(GO:0042736)
0.1 0.1 GO:0022838 substrate-specific channel activity(GO:0022838)
0.1 0.1 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.1 0.2 GO:0030332 cyclin binding(GO:0030332)
0.1 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.1 1.2 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 0.4 GO:0016597 amino acid binding(GO:0016597)
0.1 3.1 GO:0001228 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 0.3 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.1 0.2 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.3 GO:0016530 metallochaperone activity(GO:0016530)
0.1 0.4 GO:0051184 cofactor transporter activity(GO:0051184)
0.1 0.5 GO:0050661 NADP binding(GO:0050661)
0.1 0.2 GO:0001156 transcription factor activity, core RNA polymerase III binding(GO:0000995) RNA polymerase III transcription factor binding(GO:0001025) TFIIIB-type transcription factor activity(GO:0001026) TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.3 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 0.2 GO:0001128 RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly(GO:0001128)
0.0 0.3 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0016898 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.0 0.3 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.6 GO:0045182 translation regulator activity(GO:0045182)
0.0 2.5 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0016616)
0.0 0.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.0 0.0 GO:0016878 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.0 0.1 GO:0016208 AMP binding(GO:0016208)
0.0 0.0 GO:0022829 porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.0 0.2 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.0 0.5 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.1 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.1 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 1.0 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.0 0.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.9 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.5 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors(GO:0016903)
0.0 0.1 GO:0016790 thiolester hydrolase activity(GO:0016790)
0.0 0.3 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0004112 cyclic-nucleotide phosphodiesterase activity(GO:0004112)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.3 GO:0032934 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.0 0.1 GO:0005536 glucose binding(GO:0005536)
0.0 0.1 GO:0008169 C-methyltransferase activity(GO:0008169)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.6 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.2 GO:0005507 copper ion binding(GO:0005507)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0015603 siderophore transmembrane transporter activity(GO:0015343) iron chelate transmembrane transporter activity(GO:0015603) siderophore transporter activity(GO:0042927)
0.0 0.1 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.5 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.0 0.3 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.0 GO:0015085 calcium ion transmembrane transporter activity(GO:0015085)
0.0 0.2 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.0 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0 0.1 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.1 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.0 0.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.2 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 0.0 GO:0016872 intramolecular lyase activity(GO:0016872)
0.0 0.1 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.0 0.0 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.0 0.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.2 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.1 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.0 GO:0015037 glutathione-disulfide reductase activity(GO:0004362) peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.1 GO:0015149 glucose transmembrane transporter activity(GO:0005355) monosaccharide transmembrane transporter activity(GO:0015145) hexose transmembrane transporter activity(GO:0015149)
0.0 0.0 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 0.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 1.0 PID PLK1 PATHWAY PLK1 signaling events
0.1 0.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 0.4 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 25.8 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 0.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.0 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.0 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 1.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 0.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 0.1 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 0.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.1 1.4 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.1 0.4 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.1 0.1 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.1 0.7 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 0.8 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.1 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.0 0.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 25.7 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.0 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks