Results for INO4
Z-value: 0.83
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Transcription factors associated with INO4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
INO4
|
S000005468 | Transcription factor involved in phospholipid synthesis |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YGR157W Show fit | 10.07 |
Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis |
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| YDR502C Show fit | 9.29 |
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) |
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| YKL182W Show fit | 8.03 |
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities |
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| YDR497C Show fit | 7.60 |
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p |
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| YIL118W Show fit | 7.56 |
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p |
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| YCR018C Show fit | 7.34 |
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation |
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| YJL153C Show fit | 7.28 |
Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element |
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| YFR055W Show fit | 7.02 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 6.23 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YNL178W Show fit | 6.18 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
Network of associatons between targets according to the STRING database.
First level regulatory network of INO4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.3 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.5 | 13.1 | GO:0006633 | fatty acid biosynthetic process(GO:0006633) |
| 0.7 | 12.4 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.3 | 12.0 | GO:0006414 | translational elongation(GO:0006414) |
| 1.3 | 11.9 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 2.5 | 10.2 | GO:0046500 | S-adenosylmethionine metabolic process(GO:0046500) |
| 0.1 | 9.8 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.5 | 8.9 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) |
| 0.5 | 7.7 | GO:0006037 | cell wall chitin metabolic process(GO:0006037) |
| 1.9 | 7.6 | GO:0090338 | regulation of formin-nucleated actin cable assembly(GO:0090337) positive regulation of formin-nucleated actin cable assembly(GO:0090338) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.2 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 0.2 | 16.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 15.2 | GO:0005829 | cytosol(GO:0005829) |
| 0.2 | 13.1 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 10.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 7.5 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.6 | 6.8 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
| 0.1 | 5.4 | GO:0043332 | mating projection tip(GO:0043332) |
| 1.0 | 5.2 | GO:0005853 | eukaryotic translation elongation factor 1 complex(GO:0005853) |
| 0.6 | 5.1 | GO:0000144 | cellular bud neck septin ring(GO:0000144) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 16.4 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.5 | 10.6 | GO:0008170 | N-methyltransferase activity(GO:0008170) |
| 2.9 | 8.6 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
| 0.2 | 8.6 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 2.0 | 8.0 | GO:0016417 | S-acyltransferase activity(GO:0016417) |
| 2.4 | 7.3 | GO:0016872 | intramolecular lyase activity(GO:0016872) |
| 1.4 | 7.1 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.5 | 7.0 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 1.1 | 6.5 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 0.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 0.6 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.5 | 0.5 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.1 | 0.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.4 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 0.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 0.3 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 0.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 0.2 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 7.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.8 | 7.0 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.2 | 3.9 | REACTOME INFLUENZA LIFE CYCLE | Genes involved in Influenza Life Cycle |
| 0.6 | 2.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 2.2 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.6 | 1.8 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 1.7 | REACTOME LAGGING STRAND SYNTHESIS | Genes involved in Lagging Strand Synthesis |
| 0.5 | 1.4 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.3 | 1.4 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 0.6 | 1.2 | REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE | Genes involved in MyD88:Mal cascade initiated on plasma membrane |