Results for HAC1
Z-value: 0.84
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Transcription factors associated with HAC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
HAC1
|
S000001863 | Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YFR055W Show fit | 6.79 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 5.38 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YDL055C Show fit | 5.34 |
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure |
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| YOR315W Show fit | 3.66 |
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate |
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| YJR145C Show fit | 3.66 |
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein |
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| YPL250W-A Show fit | 3.34 |
Identified by fungal homology and RT-PCR |
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| YHR136C Show fit | 3.21 |
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
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| YGL148W Show fit | 3.21 |
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids |
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| YDR044W Show fit | 3.04 |
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) |
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| YGR108W Show fit | 2.98 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
Network of associatons between targets according to the STRING database.
First level regulatory network of HAC1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.7 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 0.0 | 8.5 | GO:0042254 | ribosome biogenesis(GO:0042254) |
| 2.3 | 6.8 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 2.2 | 6.6 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673) |
| 0.4 | 6.2 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.1 | 5.7 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 1.2 | 5.0 | GO:0009423 | chorismate biosynthetic process(GO:0009423) |
| 1.1 | 4.6 | GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461) |
| 0.8 | 4.1 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.4 | 3.9 | GO:0006797 | polyphosphate metabolic process(GO:0006797) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 14.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 6.6 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 4.4 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 4.0 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.1 | 3.7 | GO:0005844 | polysome(GO:0005844) |
| 0.0 | 3.2 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 3.0 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.7 | 2.9 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207) |
| 0.4 | 2.8 | GO:0005688 | U6 snRNP(GO:0005688) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.9 | 5.5 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.2 | 5.5 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 1.8 | 5.3 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.0 | 5.2 | GO:0003723 | RNA binding(GO:0003723) |
| 0.1 | 4.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.4 | 4.0 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 1.3 | 3.9 | GO:0016838 | carbon-oxygen lyase activity, acting on phosphates(GO:0016838) |
| 0.2 | 3.4 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.1 | 3.4 | GO:0003924 | GTPase activity(GO:0003924) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.4 | 1.5 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.3 | 0.8 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 0.4 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 0.3 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 0.3 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.3 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 0.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.1 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.3 | 4.8 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.4 | 1.6 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.4 | 1.5 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |
| 0.2 | 1.5 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.5 | 1.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 0.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 0.7 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.1 | 0.6 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 0.2 | 0.5 | REACTOME INFLUENZA LIFE CYCLE | Genes involved in Influenza Life Cycle |