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Results for HAC1

Z-value: 0.84

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Transcription factors associated with HAC1

Gene Symbol Gene ID Gene Info
HAC1
S000001863 Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog)

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAC1YFL031W-0.461.7e-02Click!

Activity profile of HAC1 motif

Sorted Z-values of HAC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YFR055W 6.79
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YFR056C 5.38 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YDL055C 5.34
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YOR315W 3.66
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YJR145C 3.66
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YPL250W-A 3.34 Identified by fungal homology and RT-PCR
YHR136C 3.21
SPL2
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGL148W 3.21
ARO2
Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids
YDR044W 3.04
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YGR108W 2.98
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YMR290C 2.90
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YJR070C 2.85
LIA1
Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning
YMR290W-A 2.81 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YJR009C 2.79
TDH2
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall
YJR071W 2.62 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR137W 2.44
ARO9
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism
YER177W 2.38
BMH1
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling
YHL015W 2.26
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YER001W 2.26
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YNL178W 2.25
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YOR293W 2.16
RPS10A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10
YNR054C 2.11
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YKL164C 2.09
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YEL001C 2.04
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YHR010W 2.04
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YML088W 2.02
UFO1
F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
YBR158W 1.98
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YLR154C 1.98
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YKR057W 1.95
RPS21A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein
YAL003W 1.92
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YDL023C 1.83 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YDR023W 1.82
SES1
Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
YLR154W-A 1.79 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YIL053W 1.76
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YLR432W 1.74
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YBR249C 1.74
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YKL165C 1.74
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YLR150W 1.73
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YLR154W-B 1.73 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YER124C 1.70
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YML123C 1.69
PHO84
High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p
YMR217W 1.67
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YDL192W 1.62
ARF1
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YNL030W 1.62
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YJL158C 1.60
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YDL022W 1.59
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YCR099C 1.56 Putative protein of unknown function
YLR029C 1.54
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YPL019C 1.53
VTC3
Vacuolar membrane protein involved in vacuolar polyphosphate accumulation; functions as a regulator of vacuolar H+-ATPase activity and vacuolar transporter chaperones; involved in non-autophagic vacuolar fusion
YER146W 1.52
LSM5
Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
YER073W 1.47
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YML074C 1.46
FPR3
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YGR037C 1.46
ACB1
Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes
YAL038W 1.45
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YLR048W 1.43
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YDR040C 1.41
ENA1
P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance
YER137C 1.40 Putative protein of unknown function
YOR025W 1.40
HST3
Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism
YIL127C 1.40 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
YOR313C 1.39
SPS4
Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage
YPL037C 1.38
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YDR502C 1.37
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YJR022W 1.36
LSM8
Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA
YDR041W 1.36
RSM10
Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
YOR096W 1.35
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YBL085W 1.34
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YLR257W 1.34 Putative protein of unknown function
YJL167W 1.30
ERG20
Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis
YFR054C 1.30 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR089C 1.28
GAR1
Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA
YPL177C 1.27
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YML121W 1.26
GTR1
Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB
YLR292C 1.26
SEC72
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YML073C 1.25
RPL6A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA
YOR198C 1.25
BFR1
Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity
YOR314W 1.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YGL179C 1.21
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGR214W 1.20
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YGL097W 1.19
SRM1
Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YJR010W 1.18
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YGR180C 1.17
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YGR040W 1.16
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YDR471W 1.16
RPL27B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein
YLR154W-C 1.16
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YDR210W 1.14 Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGL120C 1.14
PRP43
RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
YLR065C 1.13 Putative protein of unknown function; YLR065C is not an essential gene
YMR208W 1.10
ERG12
Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate
YDR086C 1.07
SSS1
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YBR171W 1.07
SEC66
Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YOR288C 1.05
MPD1
Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation
YGR242W 1.05 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YOR254C 1.03
SEC63
Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YCL036W 1.02
GFD2
Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation
YOR153W 1.02
PDR5
Plasma membrane ATP-binding cassette (ABC) transporter, short-lived multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
YDL202W 1.01
MRPL11
Mitochondrial ribosomal protein of the large subunit
YDR033W 0.99
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YDR146C 0.99
SWI5
Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase
YOL031C 0.99
SIL1
Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein
YJL115W 0.98
ASF1
Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition
YMR194C-A 0.98 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER052C 0.96
HOM3
Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
YDR509W 0.95 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR277W 0.95
FCP1
Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)
YJL188C 0.95
BUD19
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YDR508C 0.94
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YJL168C 0.93
SET2
Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YBR066C 0.93
NRG2
Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YCL024W 0.93
KCC4
Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p
YGR156W 0.93
PTI1
Pta1p Interacting protein
YMR049C 0.92
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YER055C 0.91
HIS1
ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
YGL105W 0.91
ARC1
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YJR094W-A 0.90
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YMR144W 0.90 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YGR241C 0.90
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YDL022C-A 0.89 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YCL023C 0.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4
YAL007C 0.87
ERP2
Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles
YKR074W 0.87
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YKL218C 0.87
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YPL010W 0.87
RET3
Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YAR008W 0.86
SEN34
Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YNL031C 0.86
HHT2
One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YDR098C 0.85
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YIL118W 0.85
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YJR076C 0.83
CDC11
Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
YNL113W 0.82
RPC19
RNA polymerase subunit, common to RNA polymerases I and III
YGR050C 0.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR325C 0.81
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YPR038W 0.81
IRC16
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci
YJL011C 0.81
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YCL037C 0.81
SRO9
Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif
YAL023C 0.80
PMT2
Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt1p, can instead interact with Pmt5p in some conditions; target for new antifungals
YBR118W 0.79
TEF2
Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes
YGL149W 0.79 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C.
YCR087C-A 0.79
LUG1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YIL076W 0.78
SEC28
Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth
YHR181W 0.77
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YPR037C 0.77
ERV2
Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
YGR200C 0.77
ELP2
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin
YNL066W 0.77
SUN4
Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family
YFL045C 0.77
SEC53
Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen
YIL011W 0.75
TIR3
Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth
YMR015C 0.75
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YGR086C 0.75
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YGR052W 0.75
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YPL086C 0.73
ELP3
Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
YCR051W 0.73 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene
YOR074C 0.72
CDC21
Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YPL143W 0.72
RPL33A
N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YIL052C 0.72
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YCR012W 0.71
PGK1
3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YHR032W-A 0.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A
YEL027W 0.71
CUP5
Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis
YPL254W 0.71
HFI1
Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions
YPL093W 0.71
NOG1
Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
YLR066W 0.70
SPC3
Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23
YCR053W 0.70
THR4
Threonine synthase, conserved protein that catalyzes formation of threonine from 0-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
YMR125W 0.70
STO1
Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80
YBR162C 0.70
TOS1
Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YHR216W 0.69
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YPL079W 0.69
RPL21B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein
YOR073W-A 0.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR
YHR045W 0.67 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
YLR185W 0.67
RPL37A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YHR149C 0.67
SKG6
Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
YML012W 0.66
ERV25
Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport
YDL179W 0.66
PCL9
Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p
YOR039W 0.65
CKB2
Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases
YLR183C 0.65
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YJL026W 0.65
RNR2
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YML119W 0.63 Putative protein of unknown funtion; YML119W is not an essential gene; potential Cdc28p substrate
YJR006W 0.63
POL31
DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair
YOR287C 0.63 Putative protein of unknown function; may play a role in the ribosome and rRNA biosynthesis based on expression profiles and mutant phenotype
YMR083W 0.63
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YGL034C 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL068C 0.63 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL211C 0.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YNL043C 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W
YML018C 0.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene
YBL092W 0.62
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YOR277C 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YFR001W 0.62
LOC1
Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles
YMR116C 0.61
ASC1
G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YFR041C 0.61
ERJ5
Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response
YGL123W 0.61
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YGL123C-A 0.61 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGR090W 0.60
UTP22
Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
YPR195C 0.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR006C 0.60
SSK1
Cytoplasmic response regulator, part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate
YBL040C 0.60
ERD2
HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
YAR071W 0.60
PHO11
One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2
YOR143C 0.59
THI80
Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YML028W 0.59
TSA1
Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype
YJL091C 0.59
GWT1
Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YNL231C 0.59
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YKL008C 0.59
LAC1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
YGL031C 0.58
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YLR206W 0.58
ENT2
Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus

Network of associatons between targets according to the STRING database.

First level regulatory network of HAC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
2.2 6.6 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.2 5.0 GO:0009423 chorismate biosynthetic process(GO:0009423)
1.1 4.6 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.8 2.5 GO:0097052 L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053)
0.8 4.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.8 2.4 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.7 2.8 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.6 1.8 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.6 1.7 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.6 2.8 GO:0006721 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.5 1.6 GO:0035950 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.5 1.6 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.5 3.3 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.5 3.3 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.4 2.7 GO:0006491 N-glycan processing(GO:0006491)
0.4 1.7 GO:0015867 ATP transport(GO:0015867)
0.4 1.3 GO:0019413 ethanol catabolic process(GO:0006068) acetate biosynthetic process(GO:0019413) primary alcohol catabolic process(GO:0034310)
0.4 3.6 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.4 1.6 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
0.4 1.6 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.4 3.9 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.4 0.8 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.4 6.2 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.4 2.3 GO:0071406 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.4 1.9 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.4 2.7 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.4 1.5 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
0.4 1.5 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.3 1.0 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.3 3.5 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.3 0.6 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.3 0.6 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
0.3 1.4 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.3 1.7 GO:0009088 threonine biosynthetic process(GO:0009088)
0.3 1.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.3 1.1 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.3 1.3 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.3 1.0 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.2 2.0 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.2 1.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
0.2 0.7 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.2 1.0 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.2 1.4 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 1.6 GO:0034729 histone H3-K79 methylation(GO:0034729)
0.2 1.1 GO:0000390 spliceosomal complex disassembly(GO:0000390)
0.2 1.6 GO:0033313 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.2 3.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.2 1.1 GO:0006110 regulation of glycolytic process(GO:0006110)
0.2 1.1 GO:0032231 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.2 3.6 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.2 0.8 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.2 0.2 GO:0046417 chorismate metabolic process(GO:0046417)
0.2 1.0 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.2 0.8 GO:0051693 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.2 0.6 GO:0070827 chromatin maintenance(GO:0070827)
0.2 0.6 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032) negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.2 0.6 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.2 1.1 GO:0045860 positive regulation of protein kinase activity(GO:0045860)
0.2 0.7 GO:0019365 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.2 1.3 GO:0031120 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.2 0.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.2 0.5 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
0.2 0.3 GO:0032239 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.2 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 20.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 0.2 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.2 0.3 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.2 0.6 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.2 1.2 GO:0006901 vesicle coating(GO:0006901)
0.1 0.9 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.3 GO:0046677 response to antibiotic(GO:0046677)
0.1 0.4 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.1 0.7 GO:0006465 signal peptide processing(GO:0006465)
0.1 2.4 GO:0072593 reactive oxygen species metabolic process(GO:0072593)
0.1 0.6 GO:0006021 inositol biosynthetic process(GO:0006021)
0.1 0.5 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.1 0.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.1 0.4 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.5 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 0.5 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.1 0.6 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.4 GO:0001174 DNA-templated transcriptional start site selection(GO:0001173) transcriptional start site selection at RNA polymerase II promoter(GO:0001174)
0.1 1.7 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.1 1.6 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.5 GO:0000296 spermine transport(GO:0000296)
0.1 0.1 GO:0010695 regulation of spindle pole body separation(GO:0010695)
0.1 0.7 GO:0043457 regulation of cellular respiration(GO:0043457)
0.1 0.4 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.1 0.1 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.1 0.6 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.4 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.1 0.5 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.1 0.7 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.9 GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled(GO:0030846)
0.1 0.6 GO:0035392 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.1 0.7 GO:0046184 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 1.1 GO:0000105 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 0.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.4 GO:0007535 donor selection(GO:0007535)
0.1 0.8 GO:0032447 protein urmylation(GO:0032447)
0.1 0.3 GO:0010922 positive regulation of phosphatase activity(GO:0010922)
0.1 0.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.1 0.2 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.1 0.3 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.1 0.4 GO:0098610 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.1 0.5 GO:0071333 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.1 0.7 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.6 GO:0072595 maintenance of protein localization in organelle(GO:0072595)
0.1 0.6 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.1 0.3 GO:0006624 vacuolar protein processing(GO:0006624)
0.1 1.6 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 1.0 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.1 0.7 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.3 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.1 0.3 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.1 0.2 GO:0042992 regulation of transcription factor import into nucleus(GO:0042990) negative regulation of transcription factor import into nucleus(GO:0042992)
0.1 0.3 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 5.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.1 0.4 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.1 0.3 GO:0034398 telomere tethering at nuclear periphery(GO:0034398)
0.1 0.4 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.1 0.8 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 0.3 GO:0030497 fatty acid elongation(GO:0030497)
0.1 0.2 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.2 GO:0009847 spore germination(GO:0009847)
0.1 0.3 GO:0015883 FAD transport(GO:0015883)
0.1 1.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.1 1.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 2.4 GO:0006694 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.1 2.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.2 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.1 0.5 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.1 0.2 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.1 1.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.4 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.1 1.3 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.2 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.1 0.3 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.1 0.6 GO:0055070 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.4 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.2 GO:0006086 acetyl-CoA biosynthetic process from pyruvate(GO:0006086)
0.1 0.5 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1 0.2 GO:0030308 negative regulation of cell growth(GO:0030308) negative regulation of pseudohyphal growth(GO:2000221)
0.1 1.5 GO:0000054 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.1 0.7 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.1 0.7 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.1 0.5 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.2 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.2 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.4 GO:0006563 L-serine metabolic process(GO:0006563)
0.0 0.2 GO:0009636 response to toxic substance(GO:0009636)
0.0 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.9 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.0 GO:0034965 intronic snoRNA processing(GO:0031070) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) intronic box C/D snoRNA processing(GO:0034965)
0.0 0.0 GO:0006531 aspartate metabolic process(GO:0006531)
0.0 0.0 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.4 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.0 0.1 GO:0030837 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.0 0.1 GO:0043171 peptide catabolic process(GO:0043171)
0.0 0.1 GO:0009162 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate metabolic process(GO:0019692) deoxyribose phosphate biosynthetic process(GO:0046385)
0.0 1.0 GO:0006414 translational elongation(GO:0006414)
0.0 0.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 8.5 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.2 GO:0097549 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.0 0.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.0 0.3 GO:0010526 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.2 GO:0000921 septin ring assembly(GO:0000921)
0.0 0.1 GO:0043902 positive regulation of multi-organism process(GO:0043902)
0.0 0.2 GO:0030007 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.3 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 0.3 GO:0006816 calcium ion transport(GO:0006816)
0.0 1.7 GO:0016311 dephosphorylation(GO:0016311)
0.0 0.1 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.0 0.3 GO:0032120 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.0 0.2 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.0 0.1 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0051382 centromere complex assembly(GO:0034508) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383)
0.0 0.2 GO:0007323 peptide pheromone maturation(GO:0007323)
0.0 0.3 GO:1990778 protein localization to plasma membrane(GO:0072659) establishment of protein localization to plasma membrane(GO:0090002) protein localization to cell periphery(GO:1990778)
0.0 0.1 GO:0009306 protein secretion(GO:0009306)
0.0 0.5 GO:0045859 regulation of protein kinase activity(GO:0045859)
0.0 0.2 GO:0042559 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.1 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.0 0.2 GO:0006273 lagging strand elongation(GO:0006273)
0.0 0.7 GO:0007015 actin filament organization(GO:0007015)
0.0 0.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.4 GO:0006612 protein targeting to membrane(GO:0006612)
0.0 0.3 GO:0045047 protein targeting to ER(GO:0045047)
0.0 0.1 GO:0006900 membrane budding(GO:0006900)
0.0 0.3 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.1 GO:2000134 negative regulation of cell cycle G1/S phase transition(GO:1902807) negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 0.6 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0006272 leading strand elongation(GO:0006272)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0006862 nucleotide transport(GO:0006862)
0.0 0.1 GO:0006551 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.2 GO:0030491 heteroduplex formation(GO:0030491)
0.0 0.1 GO:0010388 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.2 GO:0090662 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.2 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.0 0.1 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.0 GO:0031138 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.0 0.2 GO:0009267 cellular response to starvation(GO:0009267)
0.0 0.2 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.1 GO:0006855 drug transmembrane transport(GO:0006855)
0.0 0.1 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) peptidyl-histidine modification(GO:0018202)
0.0 0.1 GO:0043102 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.0 0.0 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.0 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.0 0.0 GO:0043647 inositol phosphate biosynthetic process(GO:0032958) inositol phosphate metabolic process(GO:0043647)
0.0 0.3 GO:0007124 pseudohyphal growth(GO:0007124)
0.0 0.1 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.0 0.1 GO:0097033 mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.0 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.0 0.1 GO:0006882 cellular zinc ion homeostasis(GO:0006882) zinc ion homeostasis(GO:0055069)
0.0 0.1 GO:1901264 carbohydrate derivative transport(GO:1901264)
0.0 0.1 GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.7 2.9 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.6 2.4 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.5 2.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.5 1.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.5 1.4 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.4 1.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.4 1.1 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.4 2.8 GO:0005688 U6 snRNP(GO:0005688)
0.3 1.3 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.3 19.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 0.9 GO:0070545 PeBoW complex(GO:0070545)
0.3 0.9 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.3 1.1 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.3 0.8 GO:0072687 meiotic spindle(GO:0072687)
0.3 2.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 1.3 GO:0034448 EGO complex(GO:0034448)
0.3 1.3 GO:0032545 CURI complex(GO:0032545)
0.3 1.5 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 0.7 GO:0005787 signal peptidase complex(GO:0005787)
0.2 0.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.2 0.8 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.2 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.2 2.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 2.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 0.5 GO:0045298 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.2 0.7 GO:0005822 inner plaque of spindle pole body(GO:0005822)
0.2 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 14.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.3 GO:0042597 periplasmic space(GO:0042597)
0.2 0.6 GO:0044611 nuclear pore inner ring(GO:0044611)
0.2 1.9 GO:0032161 cellular bud neck septin structure(GO:0000399) cleavage apparatus septin structure(GO:0032161)
0.1 0.6 GO:0005880 nuclear microtubule(GO:0005880)
0.1 1.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)
0.1 1.1 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 0.7 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.5 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.8 GO:0032126 eisosome(GO:0032126)
0.1 0.5 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.1 0.4 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.1 3.7 GO:0005844 polysome(GO:0005844)
0.1 0.4 GO:0051286 cell tip(GO:0051286)
0.1 1.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 0.4 GO:0044697 HICS complex(GO:0044697)
0.1 0.3 GO:0000417 HIR complex(GO:0000417)
0.1 1.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.8 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.1 4.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 2.8 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 0.3 GO:0046930 pore complex(GO:0046930)
0.1 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.4 GO:0033551 monopolin complex(GO:0033551)
0.1 0.6 GO:0005884 actin filament(GO:0005884)
0.1 0.3 GO:0043529 GET complex(GO:0043529)
0.1 2.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.1 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.1 0.6 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 0.6 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.1 0.3 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.1 0.2 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 0.6 GO:0000792 heterochromatin(GO:0000792)
0.1 1.0 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1 1.3 GO:0030118 clathrin coat(GO:0030118)
0.1 0.3 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.1 0.3 GO:0034044 exomer complex(GO:0034044)
0.1 0.2 GO:0000814 ESCRT II complex(GO:0000814)
0.1 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 0.2 GO:0045254 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.1 0.7 GO:0034399 nuclear periphery(GO:0034399)
0.1 0.2 GO:0000131 incipient cellular bud site(GO:0000131)
0.1 4.4 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.3 GO:0070772 PAS complex(GO:0070772)
0.0 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.6 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 6.6 GO:0005933 cellular bud(GO:0005933)
0.0 0.1 GO:0005940 septin ring(GO:0005940)
0.0 0.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.2 GO:0005871 kinesin complex(GO:0005871)
0.0 1.9 GO:0030684 preribosome(GO:0030684)
0.0 1.1 GO:0015935 small ribosomal subunit(GO:0015935)
0.0 0.2 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.2 GO:0034967 Set3 complex(GO:0034967)
0.0 3.2 GO:0005730 nucleolus(GO:0005730)
0.0 0.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.2 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.5 GO:0016586 RSC complex(GO:0016586)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.3 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.5 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.3 GO:0070210 Rpd3L-Expanded complex(GO:0070210)
0.0 0.2 GO:0033176 vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 0.1 GO:0031389 DNA replication factor C complex(GO:0005663) Rad17 RFC-like complex(GO:0031389)
0.0 0.1 GO:0042729 DASH complex(GO:0042729)
0.0 0.3 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 0.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0032045 eukaryotic translation initiation factor 2B complex(GO:0005851) guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.7 GO:0005794 Golgi apparatus(GO:0005794)
0.0 0.1 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.6 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0070568 guanylyltransferase activity(GO:0070568)
1.3 3.9 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.9 5.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.8 2.4 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.8 2.4 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.8 2.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.8 3.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.7 2.1 GO:0019003 GDP binding(GO:0019003)
0.6 2.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.6 0.6 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
0.5 2.5 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.4 1.7 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.4 1.7 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.4 2.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.4 1.7 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.4 1.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.4 4.0 GO:0004497 monooxygenase activity(GO:0004497)
0.4 2.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.4 1.5 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 1.0 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.3 0.9 GO:0072341 modified amino acid binding(GO:0072341)
0.3 3.3 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 2.0 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.3 2.7 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.3 2.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 1.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 1.2 GO:0070403 NAD+ binding(GO:0070403)
0.2 1.2 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.2 0.7 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.9 GO:0016841 ammonia-lyase activity(GO:0016841)
0.2 1.1 GO:0004707 MAP kinase activity(GO:0004707)
0.2 0.9 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 1.3 GO:0004030 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 0.8 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.2 0.6 GO:0016504 peptidase activator activity(GO:0016504)
0.2 1.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.2 0.7 GO:0005034 osmosensor activity(GO:0005034)
0.2 2.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.2 0.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.2 0.5 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 0.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.2 0.5 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.2 0.5 GO:0005253 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308)
0.2 0.3 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 1.9 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.2 0.6 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.2 5.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.2 0.5 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.2 1.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.2 1.3 GO:1901681 sulfur compound binding(GO:1901681)
0.2 3.4 GO:0019901 protein kinase binding(GO:0019901)
0.2 0.3 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.2 1.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.2 31.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 0.5 GO:0016872 intramolecular lyase activity(GO:0016872)
0.1 0.6 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.1 1.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.1 1.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.8 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 0.5 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.7 GO:0005216 ion channel activity(GO:0005216)
0.1 0.5 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.1 0.5 GO:0008252 nucleotidase activity(GO:0008252)
0.1 2.7 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.5 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
0.1 0.4 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.3 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 1.2 GO:0015079 potassium ion transmembrane transporter activity(GO:0015079)
0.1 1.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.8 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 1.5 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.3 GO:0009922 fatty acid elongase activity(GO:0009922)
0.1 0.9 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.1 3.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.3 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 0.8 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.1 0.5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 0.9 GO:0042054 histone-lysine N-methyltransferase activity(GO:0018024) histone methyltransferase activity(GO:0042054)
0.1 0.4 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.1 0.4 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.1 4.1 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.3 GO:0008144 drug binding(GO:0008144)
0.1 0.4 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 0.7 GO:0030276 clathrin binding(GO:0030276)
0.1 0.5 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.3 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.1 3.1 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.2 GO:0016624 pyruvate dehydrogenase activity(GO:0004738) oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.1 0.5 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.9 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 2.2 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.0 GO:0005048 signal sequence binding(GO:0005048)
0.1 0.3 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.3 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.1 0.2 GO:0004691 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.2 GO:0004100 chitin synthase activity(GO:0004100)
0.1 0.2 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.4 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.1 3.4 GO:0003924 GTPase activity(GO:0003924)
0.1 0.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 0.3 GO:0034595 phosphatidylinositol bisphosphate phosphatase activity(GO:0034593) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595)
0.1 0.4 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 0.2 GO:0016866 intramolecular transferase activity(GO:0016866)
0.0 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.2 GO:0042124 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.2 GO:0016860 intramolecular oxidoreductase activity(GO:0016860)
0.0 0.7 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.3 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.2 GO:0048256 5'-flap endonuclease activity(GO:0017108) flap endonuclease activity(GO:0048256)
0.0 0.2 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.2 GO:0016408 C-acyltransferase activity(GO:0016408)
0.0 0.8 GO:0032561 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 1.5 GO:0042393 histone binding(GO:0042393)
0.0 0.5 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.7 GO:0015926 glucosidase activity(GO:0015926)
0.0 0.1 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.4 GO:0015605 organophosphate ester transmembrane transporter activity(GO:0015605)
0.0 0.2 GO:1901618 organic hydroxy compound transmembrane transporter activity(GO:1901618)
0.0 0.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.4 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.5 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.3 GO:0051287 NAD binding(GO:0051287)
0.0 0.1 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 0.5 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.2 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.3 GO:0046983 protein dimerization activity(GO:0046983)
0.0 0.3 GO:0005507 copper ion binding(GO:0005507)
0.0 0.1 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129) RNA polymerase II transcription factor activity, TBP-class protein binding(GO:0001132)
0.0 0.2 GO:0043022 ribosome binding(GO:0043022)
0.0 0.5 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 5.2 GO:0003723 RNA binding(GO:0003723)
0.0 0.0 GO:0001179 RNA polymerase I transcription factor binding(GO:0001179) transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.2 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 0.5 GO:0003779 actin binding(GO:0003779)
0.0 0.0 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.2 GO:0003774 motor activity(GO:0003774)
0.0 0.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.0 0.4 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.0 GO:0015440 peptide-transporting ATPase activity(GO:0015440) oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.0 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 0.2 GO:0016798 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) hydrolase activity, acting on glycosyl bonds(GO:0016798)
0.0 0.1 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 0.9 GO:0008289 lipid binding(GO:0008289)
0.0 0.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.1 GO:0045182 translation regulator activity(GO:0045182)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 1.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 0.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 0.4 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 0.3 PID SHP2 PATHWAY SHP2 signaling
0.1 0.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.3 PID ATR PATHWAY ATR signaling pathway
0.0 0.1 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.1 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.5 1.4 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.4 1.6 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.4 1.5 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.3 4.8 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.3 0.3 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 0.5 REACTOME INFLUENZA LIFE CYCLE Genes involved in Influenza Life Cycle
0.2 1.5 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.2 0.5 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.2 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 0.1 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.1 0.4 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.6 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.1 0.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.4 REACTOME LAGGING STRAND SYNTHESIS Genes involved in Lagging Strand Synthesis
0.1 0.2 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.1 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0 0.2 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME G1 S TRANSITION Genes involved in G1/S Transition