Results for GSM1
Z-value: 1.58
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Transcription factors associated with GSM1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GSM1
|
S000003639 | Putative zinc cluster protein of unknown function |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YLR377C Show fit | 18.59 |
Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism |
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| YJR095W Show fit | 17.51 |
Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
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| YJR048W Show fit | 15.51 |
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration |
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| YKR097W Show fit | 14.67 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YPL223C Show fit | 14.35 |
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway |
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| YFR053C Show fit | 13.64 |
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p |
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| YLR174W Show fit | 11.53 |
Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose |
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| YDR342C Show fit | 11.50 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels |
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| YJL045W Show fit | 11.02 |
Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner |
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| YBR116C Show fit | 9.40 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GSM1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 20.8 | GO:0072593 | reactive oxygen species metabolic process(GO:0072593) |
| 0.7 | 19.1 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 6.3 | 18.8 | GO:0015755 | fructose transport(GO:0015755) |
| 2.3 | 18.6 | GO:0015758 | glucose transport(GO:0015758) |
| 1.2 | 17.2 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.3 | 16.0 | GO:0009060 | aerobic respiration(GO:0009060) |
| 1.7 | 15.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 2.8 | 13.8 | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone(GO:0006121) |
| 4.6 | 13.7 | GO:0015740 | C4-dicarboxylate transport(GO:0015740) |
| 2.5 | 12.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 100.3 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.4 | 26.2 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.1 | 17.1 | GO:0042597 | periplasmic space(GO:0042597) |
| 0.8 | 16.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 1.7 | 15.3 | GO:0045263 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 2.8 | 13.8 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.3 | 12.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 9.3 | GO:0000324 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
| 2.9 | 8.8 | GO:0031422 | RecQ helicase-Topo III complex(GO:0031422) |
| 1.6 | 6.5 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 17.6 | GO:0050308 | sugar-phosphatase activity(GO:0050308) |
| 1.5 | 16.9 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 3.6 | 14.6 | GO:0015556 | C4-dicarboxylate transmembrane transporter activity(GO:0015556) |
| 2.8 | 13.8 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 3.4 | 13.6 | GO:0004396 | hexokinase activity(GO:0004396) |
| 4.1 | 12.4 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.1 | 11.7 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 2.3 | 11.5 | GO:0015295 | solute:proton symporter activity(GO:0015295) |
| 0.5 | 10.1 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 1.5 | 8.7 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 84.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 4.9 | 14.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 1.0 | 9.0 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.6 | 1.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 1.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 1.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 0.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 0.4 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 0.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 0.3 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 84.1 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 3.7 | 33.3 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 5.2 | 15.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 0.9 | 2.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.6 | 1.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.3 | 1.0 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.4 | 0.7 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.1 | 0.5 | REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | Genes involved in Transmembrane transport of small molecules |
| 0.1 | 0.4 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 0.4 | REACTOME DIABETES PATHWAYS | Genes involved in Diabetes pathways |