Results for GCR1
Z-value: 1.58
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Transcription factors associated with GCR1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
GCR1
|
S000005996 | Transcriptional activator of genes involved in glycolysis |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YGR108W Show fit | 29.10 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YFR055W Show fit | 18.52 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YFR056C Show fit | 17.36 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YDR098C Show fit | 13.32 |
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage |
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| YOL086C Show fit | 13.08 |
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway |
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| YER177W Show fit | 12.72 |
14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling |
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| YAL038W Show fit | 12.36 |
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration |
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| YCR018C Show fit | 12.15 |
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation |
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| YIL053W Show fit | 11.95 |
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress |
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| YHR174W Show fit | 11.22 |
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose |
Network of associatons between targets according to the STRING database.
First level regulatory network of GCR1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 109.8 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 2.7 | 67.0 | GO:0006096 | glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757) |
| 3.8 | 26.9 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 1.4 | 24.9 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 6.1 | 18.2 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.1 | 14.8 | GO:0006364 | rRNA processing(GO:0006364) |
| 1.0 | 14.4 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 4.7 | 14.2 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667) |
| 1.8 | 12.7 | GO:1902707 | glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707) |
| 4.0 | 12.0 | GO:0006114 | glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 85.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.9 | 52.5 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 1.8 | 30.8 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.5 | 19.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.6 | 16.9 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 3.8 | 11.5 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 11.1 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 9.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.1 | 8.5 | GO:0042597 | periplasmic space(GO:0042597) |
| 0.1 | 8.5 | GO:0005730 | nucleolus(GO:0005730) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 135.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.2 | 27.6 | GO:0019901 | protein kinase binding(GO:0019901) |
| 4.9 | 14.7 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.9 | 13.7 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.6 | 13.5 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 4.2 | 12.5 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 4.0 | 11.9 | GO:0004619 | phosphoglycerate mutase activity(GO:0004619) |
| 2.0 | 11.9 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 3.8 | 11.5 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 1.8 | 8.9 | GO:0008443 | phosphofructokinase activity(GO:0008443) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 6.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.4 | 3.6 | PID ATR PATHWAY | ATR signaling pathway |
| 0.4 | 1.3 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.2 | 1.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 0.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 0.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 0.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 0.2 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 0.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 0.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 21.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.7 | 17.1 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 1.6 | 4.7 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.8 | 2.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.8 | 2.4 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.5 | 2.1 | REACTOME METABOLISM OF CARBOHYDRATES | Genes involved in Metabolism of carbohydrates |
| 0.5 | 2.1 | REACTOME TRANSCRIPTION COUPLED NER TC NER | Genes involved in Transcription-coupled NER (TC-NER) |
| 0.5 | 2.1 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.3 | 1.8 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |
| 0.3 | 1.7 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |