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Results for GAT4

Z-value: 0.73

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Transcription factors associated with GAT4

Gene Symbol Gene ID Gene Info
GAT4
S000001452 Protein containing GATA family zinc finger motifs

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GAT4YIR013C0.116.0e-01Click!

Activity profile of GAT4 motif

Sorted Z-values of GAT4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YIL057C 7.44 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YPL223C 5.24
GRE1
Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway
YKR097W 4.48
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YAR053W 4.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR139C 4.21
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YKL217W 4.17
JEN1
Lactate transporter, required for uptake of lactate and pyruvate; phosphorylated; expression is derepressed by transcriptional activator Cat8p during respiratory growth, and repressed in the presence of glucose, fructose, and mannose
YOR343C 3.19 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YNL093W 3.15
YPT53
GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis
YJR150C 3.09
DAN1
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YJR146W 3.06 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2
YHR212W-A 2.90 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YHR212C 2.87 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL177W 2.78 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGR236C 2.75
SPG1
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YBR072W 2.61
HSP26
Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells
YPL054W 2.60
LEE1
Zinc-finger protein of unknown function
YAR060C 2.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR096C 2.45
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YJL045W 2.45 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YML128C 2.35
MSC1
Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated
YGR067C 2.30 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YEL039C 2.27
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YLR311C 2.27 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YEL070W 2.25
DSF1
Deletion suppressor of mpt5 mutation
YOR178C 2.22
GAC1
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
YPL156C 2.15
PRM4
Pheromone-regulated protein, predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift
YPR030W 2.08
CSR2
Nuclear protein with a potential regulatory role in utilization of galactose and nonfermentable carbon sources; overproduction suppresses the lethality at high temperature of a chs5 spa2 double null mutation; potential Cdc28p substrate
YPL222W 1.99
FMP40
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YPR013C 1.99 Putative zinc finger protein; YPR013C is not an essential gene
YPR018W 1.98
RLF2
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
YAR019W-A 1.97 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR393W 1.97
ERR1
Protein of unknown function, has similarity to enolases
YAL062W 1.95
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YAL054C 1.91
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YMR191W 1.90
SPG5
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YAR050W 1.89
FLO1
Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p
YKR011C 1.88 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
YGR039W 1.82 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YGR022C 1.78 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YGR023W 1.76
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YMR316C-B 1.75 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YFR053C 1.74
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YEL030C-A 1.70 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YNR034W-A 1.69 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YPR169W-A 1.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B
YBR108W 1.64
AIM3
Protein interacting with Rsv167p; null mutant displays decreased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YAR019C 1.57
CDC15
Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p
YER093C-A 1.56
AIM11
Putative protein of unknown function; YER093C-A contains an intron; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YPR061C 1.55
JID1
Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
YMR317W 1.55 Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene
YEL030W 1.52
ECM10
Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations
YGL138C 1.52 Putative protein of unknown function; has no significant sequence similarity to any known protein
YNL036W 1.51
NCE103
Carbonic anhydrase; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway
YOR391C 1.51
HSP33
Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
YDR018C 1.50 Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; null exhibits no apparent phenotype
YDR540C 1.49
IRC4
Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR286C 1.49
BIO2
Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
YER147C 1.47
SCC4
Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX
YLL019C 1.43
KNS1
Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues
YLR332W 1.43
MID2
O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
YGR070W 1.42
ROM1
GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
YML087C 1.41
AIM33
Putative protein of unknown function; highly conserved across species and orthologous to human CYB5R4; null mutant shows increased frequency of mitochondrial genome loss (petite formation) and severe growth defect in minimal glycerol media
YJR151C 1.41
DAN4
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YDR077W 1.40
SED1
Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
YAR047C 1.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR126C 1.36 Putative protein of unknown function; transcription dependent upon Azf1p
YOR348C 1.36
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YJR152W 1.36
DAL5
Allantoin permease; ureidosuccinate permease; expression is constitutive but sensitive to nitrogen catabolite repression
YIL045W 1.35
PIG2
Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase
YKR102W 1.33
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YGR213C 1.32
RTA1
Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions
YNL052W 1.32
COX5A
Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth
YLR331C 1.30
JIP3
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
YMR104C 1.25
YPK2
Protein kinase with similarityto serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK
YDR034C 1.25
LYS14
Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer
YBR076C-A 1.24 Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR
YLR312C 1.21
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YLR037C 1.21
DAN2
Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth
YLR228C 1.20
ECM22
Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription factors; homologous to Upc2p
YIL024C 1.19 Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p
YKR101W 1.18
SIR1
Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin
YNL180C 1.18
RHO5
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity
YLR247C 1.18
IRC20
Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci
YDR277C 1.17
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YJR048W 1.17
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YJL116C 1.16
NCA3
Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family
YOL118C 1.15 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YKR100C 1.15
SKG1
Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell
YNL144C 1.14 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YCR010C 1.14
ADY2
Acetate transporter required for normal sporulation; phosphorylated in mitochondria
YNL125C 1.13
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YDL085W 1.13
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YGL089C 1.13
MF(ALPHA)2
Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
YJR078W 1.10
BNA2
Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p and Aft2p
YDR536W 1.10
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YDR322C-A 1.08
TIM11
Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase
YJR094C 1.08
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YNL179C 1.08 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YLR307C-A 1.05 Putative protein of unknown function
YAL067C 1.04
SEO1
Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide
YOR186W 1.04 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YOL055C 1.04
THI20
Multifunctional protein with both hydroxymethylpyrimidine kinase and thiaminase activities; involved in thiamine biosynthesis and also in thiamine degradation; member of a gene family with THI21 and THI22; functionally redundant with Thi21p
YGL163C 1.01
RAD54
DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family
YPL018W 1.00
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YOR208W 0.99
PTP2
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus
YIL036W 0.99
CST6
Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance
YNL091W 0.98
NST1
Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
YBR077C 0.97
SLM4
Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4
YPR191W 0.97
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YIL037C 0.96
PRM2
Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p
YNL074C 0.95
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YMR201C 0.92
RAD14
Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
YAL034C 0.92
FUN19
Non-essential protein of unknown function
YMR206W 0.92 Putative protein of unknown function; YMR206W is not an essential gene
YFR017C 0.92 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YFR017C is not an essential gene
YCR021C 0.91
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YHR139C-A 0.90 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR223C 0.89
IFH1
Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate
YIL122W 0.89
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YJR115W 0.88 Putative protein of unknown function
YPL058C 0.86
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YOR345C 0.86 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YEL012W 0.86
UBC8
Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro
YJL135W 0.85 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3
YOR346W 0.85
REV1
Deoxycytidyl transferase, forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; involved in repair of abasic sites in damaged DNA
YFL052W 0.84 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YNL194C 0.84 Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDR446W 0.83
ECM11
Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
YNL142W 0.83
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YBR132C 0.83
AGP2
High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease
YDR119W-A 0.82 Putative protein of unknown function
YBL039W-B 0.81 Putative protein of unknown function
YFR023W 0.81
PES4
Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p
YNL143C 0.80 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YCR007C 0.80 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YDR350C 0.79
ATP22
Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YER103W 0.79
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YDL224C 0.78
WHI4
Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division
YIL013C 0.77
PDR11
ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth
YDR055W 0.77
PST1
Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
YLR390W-A 0.76
CCW14
Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
YIL147C 0.76
SLN1
Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators
YNL176C 0.75 Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p
YJL057C 0.74
IKS1
Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
YIL146C 0.74
ECM37
Non-essential protein of unknown function
YIL047C 0.74
SYG1
Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
YMR135C 0.74
GID8
Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START
YNR047W 0.73 Putative protein kinase that, when overexpressed, interferes with pheromone-induced growth arrest; localizes to the cytoplasm; potential Cdc28p substrate
YMR040W 0.72
YET2
Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein
YPL116W 0.72
HOS3
Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats
YGL114W 0.71 Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YMR020W 0.71
FMS1
Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
YGL096W 0.70
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YDR351W 0.70
SBE2
Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
YDR515W 0.69
SLF1
RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts
YNL037C 0.69
IDH1
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle
YER014C-A 0.68
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YGR248W 0.68
SOL4
6-phosphogluconolactonase with similarity to Sol3p
YOR392W 0.68 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat
YMR030W 0.68
RSF1
Protein required for respiratory growth; localized to both the nucleus and mitochondrion; mutant displays decreased transcription of specific nuclear and mitochondrial genes whose products are involved in respiratory growth
YNL223W 0.67
ATG4
Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation; mediates attachment of autophagosomes to microtubules through interactions with Tub1p and Tub2p
YER167W 0.67
BCK2
Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations
YGR069W 0.67 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL089C 0.67
RLM1
MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p
YKL071W 0.67 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
YLR189C 0.66
ATG26
UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy
YJR160C 0.66
MPH3
Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication
YMR190C 0.65
SGS1
Nucleolar DNA helicase of the RecQ family involved in maintenance of genome integrity, regulates chromosome synapsis and meiotic crossing over; has similarity to human BLM and WRN helicases implicated in Bloom and Werner syndromes
YLR387C 0.65
REH1
Protein of unknown function, similar to Rei1p but not involved in bud growth; contains dispersed C2H2 zinc finger domains
YMR273C 0.65
ZDS1
Protein that interacts with silencing proteins at the telomere, involved in transcriptional silencing; has a role in localization of Bcy1p, a regulatory subunit of protein kinase A; implicated in mRNA nuclear export
YOR070C 0.65
GYP1
Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion
YHR095W 0.65 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YJL005W 0.65
CYR1
Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
YBR208C 0.65
DUR1,2
Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation
YOR027W 0.64
STI1
Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones; activates the ATPase activity of Ssa1p; homolog of mammalian Hop protein
YAL028W 0.64
FRT2
Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate
YMR090W 0.63 Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR090W is not an essential gene
YDR313C 0.61
PIB1
RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
YBL067C 0.61
UBP13
Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YHL025W 0.61
SNF6
Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p
YAL066W 0.60 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YAL063C 0.60
FLO9
Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation
YPR027C 0.60 Putative protein of unknown function
YLR402W 0.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YKL177W 0.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3
YOR141C 0.58
ARP8
Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YDR542W 0.58
PAU10
Hypothetical protein
YGL059W 0.58
PKP2
Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p
YKR096W 0.56 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc (PilT N terminus) domain
YMR107W 0.56
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YLR403W 0.56
SFP1
Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, involved in cell size modulation
YMR279C 0.56 Putative protein of unknown function; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene
YOR215C 0.55
AIM41
Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays altered rate of mitochondrial loss and reduced growth rate in minimal glycerol media
YAL047W-A 0.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR278C 0.55 Zinc-cluster protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; YLR278C is not an essential gene
YDR452W 0.55
PPN1
Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer
YPL147W 0.55
PXA1
Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins
YHR086W 0.54
NAM8
RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of MER2 pre-mRNA
YMR068W 0.54
AVO2
Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
YER075C 0.54
PTP3
Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm

Network of associatons between targets according to the STRING database.

First level regulatory network of GAT4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.4 GO:0006848 pyruvate transport(GO:0006848)
0.7 4.0 GO:0000128 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.6 5.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 2.1 GO:0015976 carbon utilization(GO:0015976)
0.5 1.5 GO:0015755 fructose transport(GO:0015755)
0.5 1.4 GO:0090630 activation of GTPase activity(GO:0090630)
0.5 1.4 GO:0071169 establishment of protein localization to chromosome(GO:0070199) establishment of protein localization to chromatin(GO:0071169)
0.5 1.4 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.4 1.3 GO:0035786 protein complex oligomerization(GO:0035786)
0.4 1.7 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.4 1.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 1.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.0 GO:0006343 establishment of chromatin silencing(GO:0006343)
0.3 0.3 GO:0036257 multivesicular body organization(GO:0036257)
0.3 1.4 GO:0015804 neutral amino acid transport(GO:0015804)
0.3 1.9 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.3 1.9 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.3 2.2 GO:0045003 double-strand break repair via synthesis-dependent strand annealing(GO:0045003)
0.3 1.5 GO:0000173 inactivation of MAPK activity involved in osmosensory signaling pathway(GO:0000173)
0.3 0.3 GO:0034225 cellular response to zinc ion starvation(GO:0034224) regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation(GO:0034225)
0.3 1.2 GO:0015793 glycerol transport(GO:0015793)
0.3 1.1 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.3 0.3 GO:0009118 regulation of glycolytic process(GO:0006110) regulation of nucleoside metabolic process(GO:0009118) regulation of nucleotide catabolic process(GO:0030811) regulation of cofactor metabolic process(GO:0051193) regulation of coenzyme metabolic process(GO:0051196) regulation of ATP metabolic process(GO:1903578)
0.3 0.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.3 2.2 GO:0015758 glucose transport(GO:0015758)
0.3 1.1 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.3 1.9 GO:0019655 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.3 2.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.2 1.5 GO:0009102 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.2 1.0 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
0.2 1.2 GO:0032443 regulation of steroid metabolic process(GO:0019218) regulation of ergosterol biosynthetic process(GO:0032443) regulation of steroid biosynthetic process(GO:0050810)
0.2 1.4 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.2 1.2 GO:2000284 positive regulation of cellular amino acid biosynthetic process(GO:2000284)
0.2 0.9 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.2 3.9 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.2 0.7 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 0.9 GO:0006598 polyamine catabolic process(GO:0006598)
0.2 1.6 GO:0051322 anaphase(GO:0051322)
0.2 1.1 GO:0034627 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.7 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.2 0.6 GO:0043419 urea catabolic process(GO:0043419)
0.2 2.1 GO:0046777 protein autophosphorylation(GO:0046777)
0.2 0.6 GO:0010971 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 4.0 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.2 1.0 GO:0006102 isocitrate metabolic process(GO:0006102)
0.2 0.6 GO:0015888 thiamine transport(GO:0015888)
0.2 0.2 GO:0019627 urea metabolic process(GO:0019627)
0.2 1.6 GO:0045912 negative regulation of cellular carbohydrate metabolic process(GO:0010677) negative regulation of gluconeogenesis(GO:0045721) negative regulation of carbohydrate metabolic process(GO:0045912)
0.2 1.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 0.4 GO:0090180 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.2 1.4 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.2 1.2 GO:0070542 response to lipid(GO:0033993) response to oleic acid(GO:0034201) response to fatty acid(GO:0070542) cellular response to lipid(GO:0071396) cellular response to fatty acid(GO:0071398) cellular response to oleic acid(GO:0071400)
0.2 0.9 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.2 0.5 GO:0006000 fructose metabolic process(GO:0006000)
0.2 0.5 GO:0043335 protein unfolding(GO:0043335)
0.2 0.6 GO:0009190 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.2 0.2 GO:0046058 cAMP metabolic process(GO:0046058)
0.1 0.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.1 0.7 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 2.9 GO:0006094 gluconeogenesis(GO:0006094)
0.1 0.7 GO:0000023 maltose metabolic process(GO:0000023)
0.1 0.8 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.6 GO:0061013 regulation of mRNA catabolic process(GO:0061013)
0.1 0.9 GO:0015851 nucleobase transport(GO:0015851)
0.1 2.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.1 0.4 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 1.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.2 GO:0008360 regulation of cell shape(GO:0008360)
0.1 1.7 GO:0044396 actin cortical patch assembly(GO:0000147) actin cortical patch organization(GO:0044396)
0.1 0.2 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.1 0.3 GO:0000348 mRNA branch site recognition(GO:0000348)
0.1 0.5 GO:0055088 lipid homeostasis(GO:0055088)
0.1 0.9 GO:0005985 sucrose metabolic process(GO:0005985) sucrose catabolic process(GO:0005987)
0.1 0.3 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.3 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.1 0.2 GO:0061647 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.1 1.0 GO:0070987 error-free translesion synthesis(GO:0070987)
0.1 0.4 GO:0006546 glycine catabolic process(GO:0006546)
0.1 2.0 GO:0015918 sterol transport(GO:0015918)
0.1 0.4 GO:0046688 response to copper ion(GO:0046688)
0.1 1.1 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 0.3 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.1 0.5 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 0.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 0.6 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 3.7 GO:0071940 ascospore wall assembly(GO:0030476) spore wall assembly(GO:0042244) spore wall biogenesis(GO:0070590) ascospore wall biogenesis(GO:0070591) fungal-type cell wall assembly(GO:0071940)
0.1 1.2 GO:0034087 establishment of sister chromatid cohesion(GO:0034085) establishment of mitotic sister chromatid cohesion(GO:0034087)
0.1 0.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.1 0.4 GO:0006482 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.3 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 2.7 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.4 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.9 GO:0006878 cellular copper ion homeostasis(GO:0006878) copper ion homeostasis(GO:0055070)
0.1 0.7 GO:0006757 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.1 0.4 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.7 GO:0071709 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.4 GO:0000755 cytogamy(GO:0000755)
0.1 0.1 GO:0051222 positive regulation of protein transport(GO:0051222) positive regulation of establishment of protein localization(GO:1904951)
0.1 2.3 GO:0043248 proteasome assembly(GO:0043248)
0.1 3.2 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.1 0.5 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.1 0.2 GO:0006592 ornithine biosynthetic process(GO:0006592)
0.1 0.4 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.1 GO:0051180 vitamin transport(GO:0051180)
0.1 0.1 GO:0009847 spore germination(GO:0009847)
0.1 0.5 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.1 0.4 GO:0034367 DNA-templated transcriptional open complex formation(GO:0001112) protein-DNA complex remodeling(GO:0001120) macromolecular complex remodeling(GO:0034367)
0.1 0.4 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.1 0.1 GO:0008272 sulfate transport(GO:0008272)
0.1 0.2 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 0.3 GO:0015886 heme transport(GO:0015886)
0.1 0.2 GO:0098542 immune effector process(GO:0002252) immune system process(GO:0002376) response to virus(GO:0009615) response to external biotic stimulus(GO:0043207) defense response to virus(GO:0051607) response to other organism(GO:0051707) defense response to other organism(GO:0098542)
0.1 1.3 GO:0000209 protein polyubiquitination(GO:0000209)
0.1 0.1 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.1 0.3 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.1 0.4 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.1 0.5 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.1 0.3 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.4 GO:0006089 lactate metabolic process(GO:0006089)
0.1 0.1 GO:0032781 positive regulation of ATPase activity(GO:0032781)
0.1 1.2 GO:0008361 regulation of cell size(GO:0008361)
0.1 0.2 GO:0006545 glycine biosynthetic process(GO:0006545)
0.1 0.3 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 0.2 GO:0000431 regulation of transcription from RNA polymerase II promoter by galactose(GO:0000431) positive regulation of transcription from RNA polymerase II promoter by galactose(GO:0000435)
0.1 0.3 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.1 0.4 GO:0006119 oxidative phosphorylation(GO:0006119)
0.1 1.0 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.5 GO:0006101 tricarboxylic acid cycle(GO:0006099) citrate metabolic process(GO:0006101)
0.1 0.2 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.1 0.2 GO:0098630 aggregation of unicellular organisms(GO:0098630) cell aggregation(GO:0098743)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.1 GO:0060194 antisense RNA transcription(GO:0009300) regulation of antisense RNA transcription(GO:0060194) negative regulation of antisense RNA transcription(GO:0060195)
0.0 0.9 GO:0040020 regulation of meiotic nuclear division(GO:0040020)
0.0 0.4 GO:0045996 negative regulation of transcription by pheromones(GO:0045996) negative regulation of transcription from RNA polymerase II promoter by pheromones(GO:0046020)
0.0 0.1 GO:0019935 cAMP-mediated signaling(GO:0019933) cyclic-nucleotide-mediated signaling(GO:0019935)
0.0 0.2 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.0 0.7 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.2 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.0 GO:0006952 defense response(GO:0006952)
0.0 0.7 GO:0006479 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.0 0.2 GO:0006113 fermentation(GO:0006113)
0.0 0.2 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.0 0.2 GO:0034030 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0 0.3 GO:0006098 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.2 GO:0097271 protein localization to bud neck(GO:0097271)
0.0 0.5 GO:0000742 karyogamy involved in conjugation with cellular fusion(GO:0000742)
0.0 3.8 GO:0006457 protein folding(GO:0006457)
0.0 0.1 GO:0090399 replicative senescence(GO:0090399)
0.0 0.1 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.0 0.2 GO:0006083 acetate metabolic process(GO:0006083)
0.0 0.1 GO:0072600 protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.0 0.1 GO:0044070 regulation of anion transport(GO:0044070)
0.0 0.3 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0 0.2 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.3 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.1 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) regulation of microtubule depolymerization(GO:0031114)
0.0 0.3 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.4 GO:0019400 glycerol metabolic process(GO:0006071) alditol metabolic process(GO:0019400)
0.0 0.5 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.3 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.1 GO:0015809 arginine transport(GO:0015809)
0.0 0.2 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.3 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.0 GO:1901977 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.4 GO:0033617 respiratory chain complex IV assembly(GO:0008535) mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.0 1.6 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.4 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.4 GO:0000902 cell morphogenesis(GO:0000902)
0.0 0.1 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.0 0.2 GO:0019932 second-messenger-mediated signaling(GO:0019932)
0.0 0.3 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.0 0.2 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.0 0.2 GO:0009306 protein secretion(GO:0009306)
0.0 0.2 GO:0006816 calcium ion transport(GO:0006816)
0.0 0.1 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0 0.0 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.0 0.1 GO:0043409 negative regulation of MAPK cascade(GO:0043409)
0.0 0.1 GO:0045117 azole transport(GO:0045117)
0.0 0.1 GO:0046113 nucleobase catabolic process(GO:0046113)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.1 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 0.2 GO:0030474 spindle pole body duplication(GO:0030474)
0.0 0.1 GO:0006167 AMP biosynthetic process(GO:0006167) AMP metabolic process(GO:0046033)
0.0 0.2 GO:0006986 response to unfolded protein(GO:0006986)
0.0 0.2 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.4 GO:0098656 anion transmembrane transport(GO:0098656)
0.0 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.0 0.0 GO:0000087 mitotic M phase(GO:0000087) M phase(GO:0000279)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:0015893 drug transport(GO:0015893)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0016233 telomere capping(GO:0016233)
0.0 0.0 GO:0034476 U4 snRNA 3'-end processing(GO:0034475) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.0 GO:0035822 gene conversion(GO:0035822)
0.0 0.0 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.3 GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:0000288)
0.0 0.2 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.1 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.0 GO:0001304 progressive alteration of chromatin involved in replicative cell aging(GO:0001304)
0.0 0.0 GO:0042843 D-xylose catabolic process(GO:0042843)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0033186 CAF-1 complex(GO:0033186)
0.7 2.0 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.5 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.4 1.5 GO:0032116 SMC loading complex(GO:0032116)
0.3 0.9 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.3 2.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 1.0 GO:0000817 COMA complex(GO:0000817)
0.2 3.2 GO:0005619 ascospore wall(GO:0005619)
0.2 6.3 GO:0070469 respiratory chain(GO:0070469)
0.2 0.7 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.2 0.7 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.2 1.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.2 1.0 GO:0034448 EGO complex(GO:0034448)
0.2 0.7 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.2 0.5 GO:0032585 multivesicular body membrane(GO:0032585)
0.2 1.2 GO:0005677 chromatin silencing complex(GO:0005677)
0.2 0.7 GO:0045334 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) endocytic vesicle(GO:0030139) endocytic vesicle membrane(GO:0030666) clathrin-coated endocytic vesicle membrane(GO:0030669) clathrin-coated endocytic vesicle(GO:0045334)
0.2 0.5 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.2 0.8 GO:0072379 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.2 0.8 GO:0032545 CURI complex(GO:0032545)
0.1 1.3 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 0.4 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 4.3 GO:0005770 late endosome(GO:0005770)
0.1 0.5 GO:0070390 transcription export complex 2(GO:0070390)
0.1 0.4 GO:0008623 CHRAC(GO:0008623)
0.1 0.7 GO:0034657 GID complex(GO:0034657)
0.1 0.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.3 GO:0031010 Isw1 complex(GO:0016587) ISWI-type complex(GO:0031010)
0.1 4.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 0.5 GO:0044233 ERMES complex(GO:0032865) ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.3 GO:0071561 organelle membrane contact site(GO:0044232) nucleus-vacuole junction(GO:0071561)
0.1 1.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 0.9 GO:0090544 SWI/SNF complex(GO:0016514) BAF-type complex(GO:0090544)
0.1 0.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.1 GO:0097002 mitochondrial inner boundary membrane(GO:0097002)
0.1 0.2 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.4 GO:0042555 MCM complex(GO:0042555)
0.1 0.5 GO:0033101 cellular bud membrane(GO:0033101)
0.1 0.4 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.1 0.4 GO:0005769 early endosome(GO:0005769)
0.0 0.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.3 GO:0071013 U2-type catalytic step 2 spliceosome(GO:0071007) catalytic step 2 spliceosome(GO:0071013)
0.0 0.1 GO:0046930 pore complex(GO:0046930)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.2 GO:0032221 Rpd3S complex(GO:0032221)
0.0 0.1 GO:0000814 ESCRT II complex(GO:0000814)
0.0 0.4 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.2 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.0 0.4 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.4 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.1 GO:0034967 Set3 complex(GO:0034967)
0.0 0.3 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.5 GO:0097346 INO80-type complex(GO:0097346)
0.0 7.1 GO:0005886 plasma membrane(GO:0005886)
0.0 0.1 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.0 0.3 GO:0046540 U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.0 0.3 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.3 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152) anaphase-promoting complex(GO:0005680)
0.0 0.8 GO:0043332 mating projection tip(GO:0043332)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.5 GO:0005811 lipid particle(GO:0005811)
0.0 0.2 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.3 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.3 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.4 GO:0000131 incipient cellular bud site(GO:0000131)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.6 GO:0015295 solute:proton symporter activity(GO:0015295)
1.0 4.0 GO:0005537 mannose binding(GO:0005537)
0.7 2.0 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.6 1.9 GO:0016208 AMP binding(GO:0016208)
0.4 1.3 GO:0008137 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 5.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.4 1.5 GO:0004396 hexokinase activity(GO:0004396)
0.4 1.5 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.4 1.1 GO:0015294 solute:cation symporter activity(GO:0015294)
0.3 1.0 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.3 1.4 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 1.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.3 0.7 GO:0042947 alpha-glucoside transmembrane transporter activity(GO:0015151) glucoside transmembrane transporter activity(GO:0042947)
0.3 1.3 GO:0005186 mating pheromone activity(GO:0000772) pheromone activity(GO:0005186)
0.3 3.6 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 1.5 GO:0016783 sulfurtransferase activity(GO:0016783)
0.3 1.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.9 GO:0099600 transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) transmembrane receptor activity(GO:0099600)
0.2 0.7 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.2 4.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 0.2 GO:0019212 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.2 2.2 GO:0016675 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 0.2 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.2 1.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 1.0 GO:0004448 isocitrate dehydrogenase activity(GO:0004448)
0.2 1.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.2 0.9 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.2 0.7 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
0.2 0.5 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)
0.2 2.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.2 0.8 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 0.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 0.3 GO:0032452 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706) histone demethylase activity(GO:0032452) histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.7 GO:0004075 biotin carboxylase activity(GO:0004075)
0.1 0.4 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 1.7 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1 1.1 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.6 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 1.0 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 2.9 GO:0008234 cysteine-type peptidase activity(GO:0008234)
0.1 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.1 2.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 4.9 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.1 1.0 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.8 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.1 0.4 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 1.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 5.1 GO:0042626 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 0.4 GO:0016898 lactate dehydrogenase activity(GO:0004457) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.3 GO:0030414 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 0.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.3 GO:0042393 histone binding(GO:0042393)
0.1 0.3 GO:0004362 glutathione-disulfide reductase activity(GO:0004362)
0.1 0.8 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.2 GO:0032183 SUMO binding(GO:0032183)
0.1 0.1 GO:0016289 CoA hydrolase activity(GO:0016289)
0.1 2.0 GO:0003684 damaged DNA binding(GO:0003684)
0.1 0.3 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.1 1.0 GO:0005353 fructose transmembrane transporter activity(GO:0005353) mannose transmembrane transporter activity(GO:0015578)
0.1 0.3 GO:0052742 phosphatidylinositol kinase activity(GO:0052742)
0.1 3.8 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 1.6 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1 0.3 GO:0004026 alcohol O-acetyltransferase activity(GO:0004026) alcohol O-acyltransferase activity(GO:0034318)
0.1 0.2 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 0.2 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.1 0.3 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.1 0.2 GO:0001156 RNA polymerase III transcription factor binding(GO:0001025) TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.5 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.3 GO:0008198 ferrous iron binding(GO:0008198)
0.1 0.3 GO:0015248 sterol transporter activity(GO:0015248)
0.1 0.5 GO:0000149 SNARE binding(GO:0000149)
0.1 0.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0004629 phospholipase C activity(GO:0004629)
0.0 0.5 GO:0043495 protein anchor(GO:0043495)
0.0 0.4 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.0 0.1 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.0 0.0 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.2 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 1.0 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 0.5 GO:0022838 substrate-specific channel activity(GO:0022838)
0.0 0.1 GO:0001097 TFIIH-class transcription factor binding(GO:0001097)
0.0 0.3 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.1 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.2 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.0 0.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.7 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.1 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0 0.2 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.0 0.5 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.0 0.1 GO:1901474 azole transmembrane transporter activity(GO:1901474)
0.0 0.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 0.3 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.4 GO:0005199 structural constituent of cell wall(GO:0005199)
0.0 0.1 GO:0016417 S-acyltransferase activity(GO:0016417)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.0 0.3 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.3 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.5 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.1 GO:0008897 holo-[acyl-carrier-protein] synthase activity(GO:0008897)
0.0 2.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.3 GO:0019213 deacetylase activity(GO:0019213)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.3 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.1 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.0 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.1 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982)
0.0 0.1 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0 0.0 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.0 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.0 0.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0098847 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 1.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 1.1 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.2 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 0.2 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 32.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.0 PID ATF2 PATHWAY ATF-2 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.5 4.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 0.7 REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT Genes involved in The citric acid (TCA) cycle and respiratory electron transport
0.2 0.5 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 0.3 REACTOME TRIF MEDIATED TLR3 SIGNALING Genes involved in TRIF mediated TLR3 signaling
0.1 0.7 REACTOME CHROMOSOME MAINTENANCE Genes involved in Chromosome Maintenance
0.1 0.9 REACTOME DNA REPAIR Genes involved in DNA Repair
0.1 0.3 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 0.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.1 0.4 REACTOME ORC1 REMOVAL FROM CHROMATIN Genes involved in Orc1 removal from chromatin
0.1 0.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME TRANSCRIPTION Genes involved in Transcription
0.0 32.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.0 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors