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Results for FZF1

Z-value: 0.63

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Transcription factors associated with FZF1

Gene Symbol Gene ID Gene Info
FZF1
S000003223 Transcription factor involved in sulfite metabolism

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FZF1YGL254W0.087.0e-01Click!

Activity profile of FZF1 motif

Sorted Z-values of FZF1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YER137C 1.73 Putative protein of unknown function
YLR154W-A 1.61 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YDR098C 1.60
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YLR154W-B 1.54 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YLR154C 1.37
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YMR049C 1.27
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YGR040W 1.27
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YER097W 1.26 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR154W-C 1.18
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YAL033W 1.14
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YGR039W 1.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
YOR028C 1.03
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YKR038C 0.92
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YIL009W 0.92
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YJL200C 0.88
ACO2
Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol
YKR092C 0.88
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YOL086C 0.80
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YDL211C 0.79 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YKL218C 0.79
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YLR257W 0.75 Putative protein of unknown function
YMR290W-A 0.72 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YGL209W 0.72
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YOR107W 0.71
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YJL011C 0.71
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YDR002W 0.70
YRB1
Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YJL162C 0.70
JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YCR018C 0.69
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YDR279W 0.66
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YJL112W 0.66
MDV1
Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats
YHR181W 0.64
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YGR293C 0.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W
YIL009C-A 0.61
EST3
Component of the telomerase holoenzyme, involved in telomere replication
YHR094C 0.59
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YJL198W 0.58
PHO90
Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
YDR502C 0.58
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YGR294W 0.57
PAU12
Hypothetical protein
YFR056C 0.57 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YPL062W 0.56 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YIL074C 0.55
SER33
3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p
YLR449W 0.54
FPR4
Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones
YOR030W 0.54
DFG16
Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YGL201C 0.54
MCM6
Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
YCR019W 0.54
MAK32
Protein necessary for structural stability of L-A double-stranded RNA-containing particles
YMR119W 0.54
ASI1
Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals
YFR055W 0.52
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR344W 0.51
RPL26A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA
YKL110C 0.50
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YLR411W 0.49
CTR3
High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae
YEL029C 0.48
BUD16
Putative pyridoxal kinase, key enzyme in vitamin B6 metabolism; involved in maintaining levels of pyridoxal 5'-phosphate, the active form of vitamin B6; required for genome integrity; homolog of E. coli PdxK; involved in bud-site selection
YOL103W 0.48
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YLR333C 0.47
RPS25B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein
YOR342C 0.46 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YMR136W 0.45
GAT2
Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine
YMR290C 0.42
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDL055C 0.42
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YGR181W 0.41
TIM13
Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YER159C 0.40
BUR6
Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YPL128C 0.40
TBF1
Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by blocking silent chromatin propagation
YDL241W 0.39 Putative protein of unknown function; YDL241W is not an essential gene
YER098W 0.38
UBP9
Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions
YMR135W-A 0.38 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL063W 0.37
KIP1
Kinesin-related motor protein required for mitotic spindle assembly and chromosome segregation; functionally redundant with Cin8p
YKL122C 0.37
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YEL053W-A 0.37 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YBR023C 0.36
CHS3
Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YBR044C 0.36
TCM62
Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
YPL177C 0.36
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YDR339C 0.35
FCF1
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p
YHR180W-A 0.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YER001W 0.34
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YDR089W 0.34 Protein of unknown function; deletion confers resistance to Nickel
YML009C 0.34
MRPL39
Mitochondrial ribosomal protein of the large subunit
YBR126W-A 0.34 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YPL055C 0.34
LGE1
Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division
YKL183C-A 0.34 Putative protein of unknown function; identified by fungal homology and RT-PCR
YDL048C 0.34
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YLR425W 0.34
TUS1
Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate
YNL302C 0.34
RPS19B
Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap
YLR407W 0.33 Putative protein of unknown function; YLR407W is not an essential gene
YJR094C 0.33
IME1
Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
YHR140W 0.33 Putative integral membrane protein of unknown function
YKR093W 0.33
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YJL168C 0.33
SET2
Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
YKL165C 0.32
MCD4
Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YHR005C-A 0.32
MRS11
Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process
YER131W 0.32
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YER012W 0.32
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YNR054C 0.32
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YMR106C 0.32
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YMR098C 0.32
ATP25
Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; null mutant displays decreased frequency of mitochondrial genome loss (petite formation)
YNL119W 0.32
NCS2
Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YLR455W 0.32 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YDR025W 0.31
RPS11A
Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins
YLR143W 0.31 Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene
YDL047W 0.31
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YGR027C 0.31
RPS25A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YPL178W 0.31
CBC2
Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif
YJR094W-A 0.30
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YBR244W 0.30
GPX2
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YOR344C 0.30
TYE7
Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression
YPR104C 0.30
FHL1
Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4
YOR130C 0.29
ORT1
Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome
YBR143C 0.29
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YNL155W 0.28 Putative protein of unknown function, contains DHHC domain, also predicted to have thiol-disulfide oxidoreductase active site
YBR300C 0.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YHR208W 0.28
BAT1
Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase
YGR195W 0.28
SKI6
3'-to-5' phosphorolytic exoribonuclease that is a subunit of the exosome; required for 3' processing of the 5.8S rRNA; involved in 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs
YNL120C 0.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
YER016W 0.28
BIM1
Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally
YIL008W 0.28
URM1
Ubiquitin-like protein with weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperature
YOR008C-A 0.27 Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres
YBL085W 0.27
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YDL192W 0.27
ARF1
ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p
YER183C 0.26
FAU1
5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis
YCL022C 0.26 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W
YKR026C 0.26
GCN3
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YPR118W 0.26
MRI1
Methylthioribose-1-phosphate isomerase, catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway
YNL154C 0.26
YCK2
Palmitoylated, plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p
YEL007W 0.26 Putative protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1)
YBR210W 0.25
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YAR018C 0.25
KIN3
Nonessential protein kinase with unknown cellular role
YDR266C 0.25 Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain
YHR212W-A 0.25 Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YCR099C 0.25 Putative protein of unknown function
YBL092W 0.25
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YPR119W 0.24
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YER147C-A 0.24 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDR005C 0.24
MAF1
Negative regulator of RNA polymerase III; component of several signaling pathways that repress polymerase III transcription in response to changes in cellular environment; targets the initiation factor TFIIIB
YNL032W 0.24
SIW14
Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
YNR061C 0.24 Putative protein of unknown function
YNL016W 0.24
PUB1
Poly(A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of a number of mRNAs; not reported to associate with polyribosomes
YCR006C 0.24 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOL159C-A 0.24 Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
YER130C 0.24 Hypothetical protein
YBR243C 0.24
ALG7
UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
YPL265W 0.23
DIP5
Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly
YMR039C 0.23
SUB1
Transcriptional coactivator, facilitates elongation by influencing enzymes that modify RNAP II, acts in a peroxide resistance pathway involving Rad2p; suppressor of TFIIB mutations
YBR249C 0.23
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YKL189W 0.23
HYM1
Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
YLL025W 0.23
PAU17
Putative protein of unknown function; YLL025W is not an essential gene
YGR228W 0.23 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C
YKL042W 0.23
SPC42
Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YNL298W 0.22
CLA4
Cdc42p activated signal transducing kinase of the PAK (p21-activated kinase) family, involved in septin ring assembly and cytokinesis; directly phosphorylates septins Cdc3p and Cdc10p; other yeast PAK family members are Ste20p and Skm1p
YER054C 0.22
GIP2
Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p
YOR043W 0.22
WHI2
Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression
YCR097W-A 0.22 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein
YOR345C 0.22 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
YKL001C 0.22
MET14
Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
YIL050W 0.22
PCL7
Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated
YJR010W 0.22
MET3
ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
YLR048W 0.22
RPS0B
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YPL143W 0.22
RPL33A
N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable
YMR177W 0.22
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YOR047C 0.22
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YLR025W 0.22
SNF7
One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
YOR315W 0.21
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YEL072W 0.21
RMD6
Protein required for sporulation
YGR264C 0.21
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YCL007C 0.21 Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A
YIL051C 0.21
MMF1
Mitochondrial protein involved in maintenance of the mitochondrial genome
YFR028C 0.21
CDC14
Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit
YOR326W 0.21
MYO2
One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
YDR088C 0.21
SLU7
RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
YOL160W 0.21 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR191W 0.21
PEX13
Integral peroxisomal membrane required for the translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
YHR010W 0.21
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YKL156W 0.20
RPS27A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein
YBR202W 0.20
MCM7
Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
YOR324C 0.20
FRT1
Tail-anchored endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress
YGR188C 0.20
BUB1
Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p
YGR155W 0.20
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YOL085C 0.20 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YNL064C 0.20
YDJ1
Protein chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family
YGL123C-A 0.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YOR381W-A 0.20 Putative protein of unknown function; identified by fungal homology and RT-PCR
YLR406C 0.20
RPL31B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p
YOR104W 0.20
PIN2
Protein that induces appearance of [PIN+] prion when overproduced
YGR265W 0.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YGL123W 0.19
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YDR043C 0.19
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YML006C 0.19
GIS4
CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway
YPL112C 0.19
PEX25
Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p
YBR247C 0.19
ENP1
Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YDR477W 0.19
SNF1
AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis
YJL122W 0.19
ALB1
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
YGL117W 0.19 Putative protein of unknown function
YOR029W 0.19 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YOL012C 0.19
HTZ1
Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin
YKR074W 0.19
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YFR020W 0.19 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL004C 0.19
BET1
Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins
YPR187W 0.19
RPO26
RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
YNL075W 0.18
IMP4
Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
YEL001C 0.18
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YEL050C 0.18
RML2
Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
YJL223C 0.18
PAU1
Part of 23-member seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
YDR395W 0.18
SXM1
Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
YFL017W-A 0.18
SMX2
Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G
YML063W 0.18
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YOR226C 0.18
ISU2
Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable

Network of associatons between targets according to the STRING database.

First level regulatory network of FZF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.3 1.1 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
0.2 1.2 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.2 0.7 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.2 0.9 GO:0031057 negative regulation of histone modification(GO:0031057)
0.2 0.8 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.2 1.3 GO:0043457 regulation of cellular respiration(GO:0043457)
0.2 0.9 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.2 0.5 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.2 1.4 GO:0042538 hyperosmotic salinity response(GO:0042538)
0.1 0.6 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.1 1.3 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.1 0.4 GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.1 0.4 GO:0009298 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
0.1 1.1 GO:0034965 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 0.4 GO:0030541 plasmid partitioning(GO:0030541)
0.1 0.5 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
0.1 0.3 GO:0035955 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.1 1.0 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.1 0.6 GO:0007535 donor selection(GO:0007535)
0.1 0.9 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.1 0.4 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015) negative regulation of telomere maintenance via telomerase(GO:0032211) negative regulation of telomere maintenance via telomere lengthening(GO:1904357)
0.1 0.3 GO:1900544 positive regulation of nucleotide metabolic process(GO:0045981) positive regulation of purine nucleotide metabolic process(GO:1900544)
0.1 0.5 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.4 GO:0042938 dipeptide transport(GO:0042938)
0.1 0.3 GO:0031114 negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114)
0.1 0.7 GO:0016559 peroxisome fission(GO:0016559)
0.1 0.1 GO:0032205 negative regulation of telomere maintenance(GO:0032205) negative regulation of homeostatic process(GO:0032845)
0.1 0.3 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
0.1 0.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.2 GO:0070814 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
0.1 0.3 GO:0048313 Golgi inheritance(GO:0048313)
0.1 0.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.3 GO:0015867 ATP transport(GO:0015867)
0.1 0.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.6 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.5 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.1 0.2 GO:0007030 Golgi organization(GO:0007030)
0.1 0.5 GO:0006279 premeiotic DNA replication(GO:0006279)
0.1 0.2 GO:0034059 response to anoxia(GO:0034059) cellular response to anoxia(GO:0071454)
0.1 0.6 GO:0034063 stress granule assembly(GO:0034063)
0.1 0.3 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.1 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.3 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.1 0.2 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.1 0.3 GO:0031591 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 0.9 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.1 0.5 GO:0070873 regulation of glycogen biosynthetic process(GO:0005979) regulation of glycogen metabolic process(GO:0070873)
0.1 0.5 GO:0015791 polyol transport(GO:0015791)
0.1 0.2 GO:0006798 polyphosphate catabolic process(GO:0006798)
0.1 0.4 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823) aldehyde biosynthetic process(GO:0046184)
0.1 1.0 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
0.1 0.1 GO:0001324 age-dependent general metabolic decline involved in chronological cell aging(GO:0001323) age-dependent response to oxidative stress involved in chronological cell aging(GO:0001324)
0.1 1.1 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.1 0.2 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.1 0.1 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 0.7 GO:0006817 phosphate ion transport(GO:0006817)
0.1 0.2 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.1 0.2 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.1 0.3 GO:0009099 valine biosynthetic process(GO:0009099)
0.1 0.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.1 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.3 GO:0043489 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.1 0.2 GO:0019413 acetate biosynthetic process(GO:0019413)
0.1 0.2 GO:0006567 threonine catabolic process(GO:0006567)
0.1 0.1 GO:0000092 mitotic anaphase B(GO:0000092)
0.1 0.5 GO:0034221 cell wall chitin biosynthetic process(GO:0006038) fungal-type cell wall chitin biosynthetic process(GO:0034221) fungal-type cell wall polysaccharide biosynthetic process(GO:0051278) fungal-type cell wall polysaccharide metabolic process(GO:0071966)
0.1 0.3 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.1 0.3 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.1 0.2 GO:0045836 positive regulation of meiotic nuclear division(GO:0045836)
0.0 0.1 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054) negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 1.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.1 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0 0.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.2 GO:0022615 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.2 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
0.0 0.6 GO:0007118 budding cell apical bud growth(GO:0007118)
0.0 0.1 GO:0046901 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.0 0.0 GO:1903339 inactivation of MAPK activity involved in cell wall organization or biogenesis(GO:0000200) regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903137) negative regulation of MAPK cascade involved in cell wall organization or biogenesis(GO:1903138) negative regulation of cell wall organization or biogenesis(GO:1903339)
0.0 0.1 GO:0033866 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.0 0.4 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 5.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 0.1 GO:1900151 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151)
0.0 0.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.3 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.1 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.0 0.1 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.1 GO:0051601 exocyst localization(GO:0051601)
0.0 0.4 GO:0006415 translational termination(GO:0006415)
0.0 0.1 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.0 0.1 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0 0.0 GO:1903322 positive regulation of protein ubiquitination(GO:0031398) positive regulation of protein modification by small protein conjugation or removal(GO:1903322)
0.0 0.2 GO:0006344 maintenance of chromatin silencing(GO:0006344) maintenance of chromatin silencing at telomere(GO:0035392)
0.0 0.1 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133) regulation of cellular amine catabolic process(GO:0033241)
0.0 0.1 GO:0019430 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305) intracellular copper ion transport(GO:0015680) removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451) cellular oxidant detoxification(GO:0098869) cellular detoxification(GO:1990748)
0.0 0.4 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785)
0.0 0.2 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.2 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.1 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.0 2.1 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.0 0.3 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.2 GO:0019660 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.0 0.1 GO:0042255 ribosome assembly(GO:0042255)
0.0 0.2 GO:0009306 protein secretion(GO:0009306)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.0 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.1 GO:0010793 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.0 0.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.3 GO:0009651 response to salt stress(GO:0009651)
0.0 0.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.1 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0043096 purine nucleobase salvage(GO:0043096) adenine metabolic process(GO:0046083) nucleobase catabolic process(GO:0046113)
0.0 0.1 GO:0009088 threonine metabolic process(GO:0006566) threonine biosynthetic process(GO:0009088)
0.0 0.3 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.1 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.0 0.2 GO:0009743 response to carbohydrate(GO:0009743) response to hexose(GO:0009746) response to glucose(GO:0009749) response to monosaccharide(GO:0034284)
0.0 0.2 GO:0042559 folic acid-containing compound biosynthetic process(GO:0009396) pteridine-containing compound biosynthetic process(GO:0042559)
0.0 0.1 GO:0035753 maintenance of DNA trinucleotide repeats(GO:0035753)
0.0 0.0 GO:1901654 response to ketone(GO:1901654)
0.0 0.1 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.0 0.3 GO:0030488 tRNA methylation(GO:0030488)
0.0 0.2 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.0 0.2 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791)
0.0 0.2 GO:0000350 generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0 0.1 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0 0.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.0 0.1 GO:2000002 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.0 0.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.6 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.6 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.1 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.0 2.1 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.0 0.1 GO:0032886 regulation of microtubule-based process(GO:0032886) regulation of microtubule cytoskeleton organization(GO:0070507)
0.0 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0006021 inositol biosynthetic process(GO:0006021)
0.0 0.5 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.1 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.0 0.1 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.0 0.1 GO:0042407 cristae formation(GO:0042407)
0.0 0.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.1 GO:0015883 FAD transport(GO:0015883)
0.0 0.1 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.1 GO:0015740 C4-dicarboxylate transport(GO:0015740)
0.0 1.1 GO:0006364 rRNA processing(GO:0006364)
0.0 0.4 GO:0006400 tRNA modification(GO:0006400)
0.0 0.0 GO:0008105 asymmetric protein localization(GO:0008105)
0.0 0.1 GO:0016072 rRNA metabolic process(GO:0016072) rRNA catabolic process(GO:0016075) ncRNA catabolic process(GO:0034661)
0.0 0.0 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.1 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.0 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.0 0.2 GO:0008033 tRNA processing(GO:0008033)
0.0 0.7 GO:0007124 pseudohyphal growth(GO:0007124)
0.0 0.0 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.0 0.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 0.1 GO:0000011 vacuole inheritance(GO:0000011)
0.0 0.1 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.0 0.0 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.1 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.0 GO:0009071 serine family amino acid catabolic process(GO:0009071)
0.0 0.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.2 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.2 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.0 0.1 GO:0006721 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.0 0.1 GO:0001120 DNA-templated transcriptional open complex formation(GO:0001112) transcriptional open complex formation at RNA polymerase II promoter(GO:0001113) protein-DNA complex remodeling(GO:0001120) macromolecular complex remodeling(GO:0034367)
0.0 0.1 GO:0051028 mRNA transport(GO:0051028)
0.0 0.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.4 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.0 0.1 GO:0016233 telomere capping(GO:0016233)
0.0 0.2 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.0 0.0 GO:0007534 gene conversion at mating-type locus(GO:0007534)
0.0 0.0 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.0 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.0 0.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.0 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.1 GO:0006534 cysteine metabolic process(GO:0006534)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0016579 protein deubiquitination(GO:0016579)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.4 1.3 GO:0070545 PeBoW complex(GO:0070545)
0.2 0.9 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.1 0.4 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 1.1 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.1 0.7 GO:0042555 MCM complex(GO:0042555)
0.1 0.6 GO:0032545 CURI complex(GO:0032545)
0.1 0.3 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
0.1 0.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.7 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 0.5 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.7 GO:0042597 periplasmic space(GO:0042597)
0.1 0.5 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1 0.5 GO:0005871 kinesin complex(GO:0005871)
0.1 0.3 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 0.2 GO:0000126 transcription factor TFIIIB complex(GO:0000126)
0.1 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.2 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 1.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 0.1 GO:0000145 exocyst(GO:0000145)
0.1 0.3 GO:0034518 RNA cap binding complex(GO:0034518)
0.1 0.5 GO:0032040 small-subunit processome(GO:0032040)
0.1 0.2 GO:0034457 Mpp10 complex(GO:0034457)
0.1 3.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 0.2 GO:0044284 mitochondrial crista junction(GO:0044284)
0.1 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.1 0.2 GO:0030869 RENT complex(GO:0030869)
0.1 0.4 GO:0051233 spindle midzone(GO:0051233)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.3 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.2 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.0 0.3 GO:0005724 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.3 GO:0005884 actin filament(GO:0005884)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.2 GO:0070772 PAS complex(GO:0070772)
0.0 0.9 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 3.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0070985 TFIIK complex(GO:0070985)
0.0 0.1 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.0 0.2 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.4 GO:0030686 90S preribosome(GO:0030686)
0.0 0.2 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.1 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.0 1.4 GO:0000131 incipient cellular bud site(GO:0000131)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176) cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 3.1 GO:0005730 nucleolus(GO:0005730)
0.0 0.1 GO:0097344 Rix1 complex(GO:0097344)
0.0 0.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.1 GO:0035339 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.1 GO:0043614 multi-eIF complex(GO:0043614)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0032126 eisosome(GO:0032126)
0.0 0.0 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.3 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.0 0.1 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.0 0.4 GO:0031201 SNARE complex(GO:0031201)
0.0 0.0 GO:0030428 cell septum(GO:0030428)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.0 GO:0043291 RAVE complex(GO:0043291)
0.0 0.0 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.6 GO:0015934 large ribosomal subunit(GO:0015934)
0.0 0.2 GO:0000786 nucleosome(GO:0000786)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.0 GO:0031499 TRAMP complex(GO:0031499)
0.0 0.1 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.4 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.1 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.0 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.1 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.5 GO:0000313 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.1 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.0 0.4 GO:0000778 condensed nuclear chromosome kinetochore(GO:0000778)
0.0 0.2 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152) anaphase-promoting complex(GO:0005680)
0.0 0.0 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.2 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.3 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.2 1.2 GO:0004707 MAP kinase activity(GO:0004707)
0.2 1.0 GO:0016841 ammonia-lyase activity(GO:0016841)
0.2 0.6 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.2 0.7 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 0.9 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 0.5 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.2 0.5 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.2 0.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025) TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.6 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1 0.4 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 1.6 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.1 0.4 GO:0004100 chitin synthase activity(GO:0004100)
0.1 1.1 GO:0004526 ribonuclease MRP activity(GO:0000171) ribonuclease P activity(GO:0004526)
0.1 0.3 GO:0000339 RNA cap binding(GO:0000339)
0.1 0.3 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 1.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.3 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.3 GO:0016504 peptidase activator activity(GO:0016504)
0.1 1.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.4 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.1 0.3 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.5 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.1 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 0.2 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIB-type transcription factor activity(GO:0001026)
0.1 0.3 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 1.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 0.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.4 GO:0008312 7S RNA binding(GO:0008312)
0.1 0.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 1.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.6 GO:0031386 protein tag(GO:0031386)
0.1 1.0 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.1 0.3 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.1 0.2 GO:0004000 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.1 0.2 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.2 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.2 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.0 0.1 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.0 0.1 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.5 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.9 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.1 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.0 0.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.2 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.3 GO:0031369 translation initiation factor binding(GO:0031369)
0.0 0.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.0 1.4 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 7.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.1 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.0 0.1 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.2 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.0 GO:0008097 5S rRNA binding(GO:0008097)
0.0 0.3 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:0016872 intramolecular lyase activity(GO:0016872)
0.0 0.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.2 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.2 GO:0019239 deaminase activity(GO:0019239)
0.0 0.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.1 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0 0.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 0.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864) phosphatase inhibitor activity(GO:0019212)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.1 GO:0019202 amino acid kinase activity(GO:0019202)
0.0 0.7 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.1 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.2 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.0 0.2 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.1 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.0 0.1 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 0.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0019888 phosphatase regulator activity(GO:0019208) protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0008186 RNA-dependent ATPase activity(GO:0008186)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.2 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.2 GO:0017069 snRNA binding(GO:0017069)
0.0 0.3 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 0.1 GO:0030291 protein serine/threonine kinase inhibitor activity(GO:0030291)
0.0 0.2 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.0 0.1 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.0 0.2 GO:0043175 RNA polymerase core enzyme binding(GO:0043175) RNA polymerase binding(GO:0070063)
0.0 0.3 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.2 GO:0070566 adenylyltransferase activity(GO:0070566)
0.0 0.1 GO:0019201 nucleotide kinase activity(GO:0019201)
0.0 0.4 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0019843 rRNA binding(GO:0019843)
0.0 0.1 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.0 0.5 GO:0015631 tubulin binding(GO:0015631)
0.0 0.0 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.0 0.3 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 1.3 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 0.2 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.0 GO:0001098 basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099)
0.0 0.1 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.0 0.1 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.0 0.1 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.0 0.0 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.1 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.0 0.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887) DNA polymerase activity(GO:0034061)
0.0 0.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.1 GO:0000149 SNARE binding(GO:0000149)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.3 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0008252 nucleotidase activity(GO:0008252)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.0 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.1 GO:0015248 oxysterol binding(GO:0008142) sterol transporter activity(GO:0015248)
0.0 0.2 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 0.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.6 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.3 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.2 PID P73PATHWAY p73 transcription factor network
0.0 0.0 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.1 PID FOXO PATHWAY FoxO family signaling
0.0 0.2 PID ATR PATHWAY ATR signaling pathway
0.0 0.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.1 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.0 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 0.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 0.7 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.1 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.7 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.1 0.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 0.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 0.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.9 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
0.0 0.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.2 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.0 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 0.1 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.0 0.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.1 REACTOME MITOTIC M M G1 PHASES Genes involved in Mitotic M-M/G1 phases
0.0 0.1 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.1 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres